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Tag Content
iUUCD ID IUUC-Pfo-096228
Ensembl Protein ID ENSPFOP00000010364.1
UniProt Accession A0A087XX61; A0A087XX61_POEFO
Genbank Protein ID ENSPFOP00000010364
Protein Name Lissencephaly-1 homolog
Genbank Nucleotide ID AYCK01000508
Gene Name pafah1b1b (1 of many); PAFAH1B1; LIS1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSPFOG00000010319.1 ENSPFOT00000010379.1 ENSPFOP00000010364.1
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 3.10e-57 188.5 336 374
UBD/Beta-Prp 1.70e-91 307.1 107 410
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlrtgvllk 37
    gH ++v+++ f ++ +++vs++dD+ti++WD++ ++ k
   Q: 336 GHDNWVRGILFhPGgRFIVSCADDKTIRIWDYKNKRCMK 374
    8***********9989***************99998876 PP
   


   UBD/Beta-Prp

   S: 9    hksvitcvkfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsv 97
    h +++t v f+p s+++t+s+d+tikvwd++ g++ r+l+gh++ v++++f+++gk+l+++s D+ ik+wd++ ++c++t++gh+++v
   Q: 107 HRAPVTRVIFHPVFSVMVTASEDATIKVWDYEAGDFERTLKGHTDSVQDISFDQTGKLLASCSADMSIKLWDFQGFECIRTMHGHDHNV 195
    6678999********************************************************************************** PP
   S: 98 lslsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtdsvysl 186
    s++++p+gd++vs+s+d+ i++w++ tg+c++ t++gh+++v++v+ ++dg+l++s+s+D+tvr+W ++++++ +l++ h++ v+++
   Q: 196 SSVAIMPNGDHIVSASRDKSIKMWEVATGYCVK-TFTGHREWVRMVRPNQDGSLIASCSNDQTVRVWVVASKECKAELRE-HEHVVECI 282
    *********************************.*********************************************9.******** PP
   S: 187 sfdsng....................kelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfspnderlvsgssDgsiriWdlrsgd 255
    ++ +++ ++l+sgs+d+t+k+wd++ g c++tl gh+++v+ + f+p + ++vs+++D++iriWd++++
   Q: 283 AWAPDSahptvleatgseskksgkpgPFLLSGSRDKTIKMWDVSIGICLMTLVGHDNWVRGILFHPGGRFIVSCADDKTIRIWDYKNKR 371
    ***************************************************************************************** PP
   S: 256 llktlqlhnssvisvavlsfgdnvlvlgsedskvniwklk 295
    ++ktl+ h++ v+s ++ + + +++v+gs d++v++w+++
   Q: 372 CMKTLSAHEHFVTSLDF-HKTAPYVVTGSVDQTVKVWECR 410
    *****************.99*****************985 PP
   

Organism Poecilia formosa
Functional Description
(View)

Functional Description



     Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. May be required for proliferation of neuronal precursors and neuronal migration.
Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. May be required for proliferation of neuronal precursors and neuronal migration.
Protein Sequence
(Fasta)
MVLSQRQRDE LNRAIADYLR SNGYEEAYST FKKEAELDIN EEVDKKYAGL LEKKWTSVIR 60
LQKKVMELES KLNEVKEDMT YGGPVGQKRD PKEWIPRPPE RYALSGHRAP VTRVIFHPVF 120
It may take some time, please wait.

Protein Fasta Sequence



>IUUC-Pfo-096228|E3,WD_repeat;UBD,Beta-Prp|Poecilia formosa
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GTGACGGATA TATTGTCCCA CTGACTGAGC GGGTGACATT TGGACCGTCG TAAACCTTCT 60
CGGCGCCTCA TAGCGGCACA GCAGAAGCTC CTCCAGGTTC GCCGTCCTCC TCCGAGCGGC 120
It may take some time, please wait.

Nucleotide Fasta Sequence



>IUUC-Pfo-096228|E3,WD_repeat;UBD,Beta-Prp|Poecilia formosa
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0131--Cell cycle
KW-0132--Cell division
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0217--Developmental protein
KW-0221--Differentiation
KW-0493--Microtubule
KW-0498--Mitosis
KW-0524--Neurogenesis
KW-1185--Reference proteome
KW-0677--Repeat
KW-0813--Transport
KW-0853--WD repeat

Interpro

IPR003143--Cyt_cd1_C
IPR017252--Dynein_regulator_LIS1
IPR020472--G-protein_beta_WD-40_rep
IPR006594--LisH
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS50896--LISH
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF08513--LisH
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00667--LisH
SM00320--WD40

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005874--C:microtubule
GO:0005875--C:microtubule associated complex
GO:0005815--C:microtubule organizing center
GO:0030154--P:cell differentiation
GO:0051301--P:cell division
GO:0000132--P:establishment of mitotic spindle orientation
GO:0007067--P:mitotic nuclear division
GO:0007399--P:nervous system development
GO:0006810--P:transport

Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ago-007862 Ashbya gossypii 27.13 3.00e-39 156.00
IUUC-Dme-031745 Drosophila melanogaster 70.32 2.00e-174 605.00
IUUC-Gmo-039166 Gadus morhua 95.12 0.00e+00 827.00
IUUC-Gac-041363 Gasterosteus aculeatus 96.59 0.00e+00 836.00
IUUC-Kpa-049351 Komagataella pastoris 29.04 1.00e-44 174.00
IUUC-Ont-071905 Oreochromis niloticus 97.56 0.00e+00 841.00
IUUC-Ola-086815 Oryzias latipes 96.59 0.00e+00 839.00
IUUC-Sce-106208 Saccharomyces cerevisiae 27.47 1.00e-36 147.00
IUUC-Tru-118179 Takifugu rubripes 96.10 0.00e+00 833.00
IUUC-Tni-120288 Tetraodon nigroviridis 95.85 0.00e+00 827.00
Created Date 25-Jun-2017

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