iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Oru-084960

Ensembl Protein ID

ORUFI03G40730.1

UniProt Accession

A0A0E0P359; A0A0E0P359_ORYRU

Protein Name

NEDD8-activating enzyme E1 regulatory subunit

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ORUFI03G40730	ORUFI03G40730.1	ORUFI03G40730.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E1	9.50e-92	309.5	12	490

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

   S: 1    YDRQirlwGeeaqeklksakvllvGagglGcEllKnLvlaGvgsitvvDmdtvevsnlnrqFLfraedvgksKAevaaealkelnpdvnveahe 94
           YDRQ+r+wG+++q++l++a+++l+ +g++G+E  KnLvl+Gvgs+tvvD d              ae  g+s+A++++ +l+eln+ vn++++e
   Q: 12   YDRQLRIWGDQGQAALEKASICLLTCGPTGTEAMKNLVLGGVGSVTVVDVD--------------AECLGQSRAKSVCSFLQELNDAVNAKFVE 91
           *************************************************65..............7889************************* PP
   S: 95   esiteleeeiv.FfkkfdvVvlaldnrearrkvnrlclnarvpliesgtlGllGqvrviikgltecyscsd...dppqktiPfctlketpn... 181
           es+ +l ++++ Ff++f+vV++++ ++ + +k++++c++a++ l+ ++++Gl G vr+++k++ +++s++d   d++++ +P+++lk++     
   Q: 92   ESPLALIDTNPsFFSQFTVVIATQLPERSLLKLDDICRKANIVLVAARSYGLTGLVRISVKEHNVIESKPDhflDDLRLHNPWVELKQFAKsid 185
           *****************************************************************************************88899 PP
   S: 182  ......aaehtiewavlfnklleeeageeevlekldseekeegkdkvkselksedeenfeeaieiavkafakttins.ikqllksfecdivtks 268
                 +++++++++v++  l+e++a +++++ +++++ek e+k ++++ + + deen++ea+e + k   +  i++ i+q++++ + ++v++s
   Q: 186  indkdpVVHKHTPYIVILVRLAEKWADAHDGRLPSTRQEKNEFKALIREHMLNLDEENYKEAVESSYKVSVTPGISDeIRQIIDD-SSAEVNSS 278
           999999******************************************************************************9.78899*** PP
   S: 269  kspfwv...........................................................................sfcsnaealq... 284
           +s+fwv                                                                           +fc+na++l+   
   Q: 279  SSDFWVlvaalkefianegngelplegtipdmtslteyyvslqkiyqakaesdclalehhvkdilkridrdpdsisrayikTFCKNARKLRvcr 372
           *******************************************************************************************666 PP
   S: 285  ........vpekvekdeevvkasap.....lylllralerfekkkgrkpgelsfekdddsavdlvtaaanlraeslgiep.kldddlikeiagn 364
                   + +   + +++++++++     +y+llra++r++++++r+pg ++ e d+d +++l+taa +  ++++g+++ +l++dli+e++++
   Q: 373  yrsmeeefSSPVLSEVQKYFTDEDYcfamnFYVLLRAVDRLAANYNRYPGIFESEIDED-VPRLKTAAVSV-MSEMGMNGaPLSEDLITEMCRF 464
           666655553355666666667777788888*******************9999999999.*****988875.6********************* PP
   S: 365  iipaiattnavvgGlaaqEviKvvsg 390
           + ++i++++a++gG+a+qEviK +++
   Q: 465  GGAEIHPVAAFIGGVASQEVIKELKQ 490
           **********************8876 PP

Organism

Oryza rufipogon

Functional Description
(View)

Regulatory subunit of the dimeric E1 enzyme. E1 activates RUB1/NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a RUB1-ECR1 thioester and free AMP. E1 finally transfers RUB1 to the catalytic cysteine of RCE1.

Protein Sequence
(Fasta)

MAAAFAEPKT KYDRQLRIWG DQGQAALEKA SICLLTCGPT GTEAMKNLVL GGVGSVTVVD 60
VDAECLGQSR AKSVCSFLQE LNDAVNAKFV EESPLALIDT NPSFFSQFTV VIATQLPERS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTCCTTGCTC CGCCTCCACT TAGCTTGAGA CCGCTTTATT CCTCGCTCAG GGAGGAGAAG 60
GCGAAGGCGA AGCAAAGCAA AACCTCGGAA GAGCGGCAGA GCCCACTCCA CACGCGGAGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR030667--APP-BP1
IPR016040--NAD(P)-bd_dom
IPR000594--ThiF_NAD_FAD-bd

Pfam

PF00899--ThiF

Gene Ontology

GO:0019781--F:NEDD8 activating enzyme activity
GO:0045116--P:protein neddylation

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000764	Aegilops tauschii	84.97	0.00e+00	843.00
IUUC-Aml-002333	Ailuropoda melanoleuca	42.28	3.00e-115	408.00
IUUC-Atr-002644	Amborella trichopoda	68.39	0.00e+00	685.00
IUUC-Apl-003446	Anas platyrhynchos	40.97	8.00e-106	377.00
IUUC-Aca-004450	Anolis carolinensis	40.48	3.00e-109	388.00
IUUC-Aly-005466	Arabidopsis lyrata	63.67	0.00e+00	682.00
IUUC-Ath-006692	Arabidopsis thaliana	64.12	0.00e+00	678.00
IUUC-Ago-007900	Ashbya gossypii	27.40	4.00e-34	138.00
IUUC-Acl-008333	Aspergillus clavatus	30.65	5.00e-54	204.00
IUUC-Afl-008529	Aspergillus flavus	30.73	4.00e-57	215.00
IUUC-Afu-009071	Aspergillus fumigatus	30.21	1.00e-52	200.00
IUUC-Ani-009443	Aspergillus nidulans	30.13	1.00e-48	186.00
IUUC-Ang-009669	Aspergillus niger	29.71	3.00e-55	209.00
IUUC-Aor-009914	Aspergillus oryzae	30.43	4.00e-55	208.00
IUUC-Ate-010450	Aspergillus terreus	30.15	3.00e-54	205.00
IUUC-Ame-011183	Astyanax mexicanus	38.26	7.00e-107	380.00
IUUC-Bgr-012111	Blumeria graminis	30.10	6.00e-45	174.00
IUUC-Bta-012583	Bos taurus	42.25	4.00e-116	411.00
IUUC-Bci-013892	Botrytis cinerea	29.40	1.00e-42	167.00
IUUC-Bdi-014592	Brachypodium distachyon	85.83	0.00e+00	852.00
IUUC-Bol-016401	Brassica oleracea	63.31	0.00e+00	674.00
IUUC-Bra-017506	Brassica rapa	62.18	0.00e+00	656.00
IUUC-Cel-018456	Caenorhabditis elegans	28.24	8.00e-57	214.00
IUUC-Cja-020007	Callithrix jacchus	42.40	6.00e-115	407.00
IUUC-Cfa-020324	Canis familiaris	42.05	2.00e-116	412.00
IUUC-Cpo-022248	Cavia porcellus	41.87	3.00e-70	258.00
IUUC-Csa-023149	Chlorocebus sabaeus	40.59	3.00e-96	345.00
IUUC-Cho-024537	Choloepus hoffmanni	36.05	1.00e-80	293.00
IUUC-Cin-025763	Ciona intestinalis	39.84	2.00e-96	345.00
IUUC-Csv-026113	Ciona savignyi	37.48	5.00e-87	314.00
IUUC-Cgl-026428	Colletotrichum gloeosporioides	28.07	7.00e-42	164.00
IUUC-Cne-026884	Cryptococcus neoformans	29.69	2.00e-54	206.00
IUUC-Dre-028140	Danio rerio	40.16	6.00e-111	394.00
IUUC-Dno-030033	Dasypus novemcinctus	41.19	8.00e-105	373.00
IUUC-Dor-030513	Dipodomys ordii	33.61	4.00e-31	128.00
IUUC-Dse-031536	Dothistroma septosporum	28.22	1.00e-47	184.00
IUUC-Dme-031683	Drosophila melanogaster	36.36	8.00e-81	293.00
IUUC-Ete-032420	Echinops telfairi	36.92	2.00e-96	345.00
IUUC-Eca-033992	Equus caballus	41.73	1.00e-94	339.00
IUUC-Eeu-034713	Erinaceus europaeus	33.17	1.00e-30	127.00
IUUC-Fca-036548	Felis catus	41.85	3.00e-116	411.00
IUUC-Fal-037600	Ficedula albicollis	40.36	5.00e-103	367.00
IUUC-Fox-038037	Fusarium oxysporum	29.79	7.00e-53	201.00
IUUC-Fso-038387	Fusarium solani	30.23	1.00e-52	200.00
IUUC-Gmo-038562	Gadus morhua	39.33	6.00e-105	374.00
IUUC-Ggr-040005	Gaeumannomyces graminis	29.81	3.00e-50	192.00
IUUC-Gga-041129	Gallus gallus	41.05	1.00e-106	379.00
IUUC-Gac-042558	Gasterosteus aculeatus	39.88	2.00e-109	389.00
IUUC-Gma-043610	Glycine max	67.54	0.00e+00	677.00
IUUC-Ggo-045611	Gorilla gorilla	41.80	7.00e-114	403.00
IUUC-Hsa-046563	Homo sapiens	42.05	5.00e-115	407.00
IUUC-Hvu-047790	Hordeum vulgare	88.12	0.00e+00	637.00
IUUC-Itr-048066	Ictidomys tridecemlineatus	42.45	6.00e-115	407.00
IUUC-Kpa-049309	Komagataella pastoris	33.47	6.00e-63	234.00
IUUC-Lch-050038	Latimeria chalumnae	41.00	5.00e-108	384.00
IUUC-Lpe-051535	Leersia perrieri	91.31	0.00e+00	887.00
IUUC-Loc-051917	Lepisosteus oculatus	38.03	9.00e-100	357.00
IUUC-Lma-053112	Leptosphaeria maculans	30.67	8.00e-56	211.00
IUUC-Laf-053690	Loxodonta africana	42.72	1.00e-117	416.00
IUUC-Mcc-055117	Macaca mulatta	41.92	5.00e-115	407.00
IUUC-Meu-056761	Macropus eugenii	35.67	4.00e-86	311.00
IUUC-Mor-057230	Magnaporthe oryzae	29.71	3.00e-53	202.00
IUUC-Mpo-057514	Magnaporthe poae	32.40	7.00e-47	181.00
IUUC-Mtr-058551	Medicago truncatula	64.45	0.00e+00	653.00
IUUC-Mla-059183	Melampsora laricipopulina	32.44	5.00e-72	264.00
IUUC-Mga-060144	Meleagris gallopavo	40.28	6.00e-103	367.00
IUUC-Mvi-060221	Microbotryum violaceum	31.99	6.00e-52	197.00
IUUC-Mmr-061325	Microcebus murinus	42.00	5.00e-114	404.00
IUUC-Mdo-062532	Monodelphis domestica	41.85	3.00e-114	404.00
IUUC-Mmu-063956	Mus musculus	41.45	1.00e-114	406.00
IUUC-Mac-064521	Musa acuminata	69.86	0.00e+00	725.00
IUUC-Mpu-066716	Mustela putorius furo	41.87	2.00e-113	402.00
IUUC-Mlu-067459	Myotis lucifugus	42.35	5.00e-117	414.00
IUUC-Nfi-068245	Neosartorya fischeri	30.77	8.00e-54	204.00
IUUC-Ncr-068910	Neurospora crassa	28.98	2.00e-48	186.00
IUUC-Nle-070034	Nomascus leucogenys	41.55	5.00e-110	390.00
IUUC-Opr-070552	Ochotona princeps	38.32	2.00e-93	335.00
IUUC-Ont-071426	Oreochromis niloticus	39.88	8.00e-112	396.00
IUUC-Oan-073389	Ornithorhynchus anatinus	38.46	6.00e-82	297.00
IUUC-Ocu-074911	Oryctolagus cuniculus	42.32	1.00e-116	412.00
IUUC-Oba-075437	Oryza barthii	96.76	0.00e+00	921.00
IUUC-Obr-076684	Oryza brachyantha	89.07	0.00e+00	819.00
IUUC-Ogl-077170	Oryza glaberrima	96.76	0.00e+00	921.00
IUUC-Ogu-078844	Oryza glumaepatula	95.59	0.00e+00	914.00
IUUC-Oin-079105	Oryza indica	96.76	0.00e+00	919.00
IUUC-Olo-080943	Oryza longistaminata	100.00	0.00e+00	959.00
IUUC-Oni-082891	Oryza nivara	99.79	0.00e+00	925.00
IUUC-Opu-083457	Oryza punctata	94.15	0.00e+00	917.00
IUUC-Osa-085358	Oryza sativa	96.36	0.00e+00	913.00
IUUC-Ola-086420	Oryzias latipes	39.83	5.00e-71	260.00
IUUC-Olu-087625	Ostreococcus lucimarinus	30.48	1.00e-53	203.00
IUUC-Oga-088810	Otolemur garnettii	42.25	1.00e-115	409.00
IUUC-Oar-089196	Ovis aries	42.00	2.00e-114	405.00
IUUC-Ptr-090617	Pan troglodytes	42.05	3.00e-115	408.00
IUUC-Pan-092761	Papio anubis	42.25	4.00e-116	411.00
IUUC-Psi-093191	Pelodiscus sinensis	38.95	1.00e-107	382.00
IUUC-Pma-094380	Petromyzon marinus	39.11	3.00e-101	361.00
IUUC-Pno-095084	Phaeosphaeria nodorum	29.43	7.00e-47	182.00
IUUC-Ppa-095798	Physcomitrella patens	53.74	5.00e-160	556.00
IUUC-Pfo-096467	Poecilia formosa	40.04	2.00e-107	382.00
IUUC-Pab-098255	Pongo abelii	43.19	2.00e-100	358.00
IUUC-Pop-099722	Populus trichocarpa	68.69	0.00e+00	712.00
IUUC-Pca-100807	Procavia capensis	48.13	2.00e-45	176.00
IUUC-Ppe-101280	Prunus persica	67.54	0.00e+00	699.00
IUUC-Pva-102333	Pteropus vampyrus	40.60	5.00e-109	387.00
IUUC-Pgr-103401	Puccinia graminis	27.91	6.00e-54	204.00
IUUC-Ptt-103889	Puccinia triticina	25.09	1.00e-46	180.00
IUUC-Pte-104355	Pyrenophora teres	30.04	7.00e-54	204.00
IUUC-Pyt-104545	Pyrenophora triticirepentis	30.60	4.00e-55	208.00
IUUC-Rno-105810	Rattus norvegicus	42.05	1.00e-114	406.00
IUUC-Sce-106397	Saccharomyces cerevisiae	30.55	1.00e-32	133.00
IUUC-Sha-106770	Sarcophilus harrisii	46.15	3.00e-63	234.00
IUUC-Sja-107926	Schizosaccharomyces japonicus	32.87	8.00e-70	257.00
IUUC-Spo-108276	Schizosaccharomyces pombe	33.00	3.00e-71	262.00
IUUC-Ssl-108387	Sclerotinia sclerotiorum	30.40	3.00e-44	172.00
IUUC-Smo-109296	Selaginella moellendorffii	52.74	1.00e-149	523.00
IUUC-Sit-110157	Setaria italica	85.46	0.00e+00	873.00
IUUC-Sly-111660	Solanum lycopersicum	66.13	0.00e+00	685.00
IUUC-Stu-112469	Solanum tuberosum	66.47	0.00e+00	692.00
IUUC-Sar-113083	Sorex araneus	32.24	9.00e-73	267.00
IUUC-Sbi-113813	Sorghum bicolor	86.06	0.00e+00	878.00
IUUC-Sre-115058	Sporisorium reilianum	32.73	2.00e-59	223.00
IUUC-Tgu-116772	Taeniopygia guttata	41.80	3.00e-105	375.00
IUUC-Tru-118686	Takifugu rubripes	39.10	3.00e-110	391.00
IUUC-Tsy-119111	Tarsius syrichta	44.49	4.00e-58	218.00
IUUC-Tni-120231	Tetraodon nigroviridis	37.98	8.00e-97	347.00
IUUC-Tca-121491	Theobroma cacao	68.15	0.00e+00	669.00
IUUC-Tre-122103	Trichoderma reesei	30.65	3.00e-56	212.00
IUUC-Tvi-122672	Trichoderma virens	29.90	3.00e-52	199.00
IUUC-Tae-125316	Triticum aestivum	85.83	0.00e+00	849.00
IUUC-Tur-126487	Triticum urartu	84.29	0.00e+00	820.00
IUUC-Tme-127097	Tuber melanosporum	32.38	2.00e-63	236.00
IUUC-Ttr-128465	Tursiops truncatus	38.80	1.00e-99	356.00
IUUC-Uma-129645	Ustilago maydis	31.24	7.00e-57	214.00
IUUC-Vda-129989	Verticillium dahliae	26.68	1.00e-32	134.00
IUUC-Vpa-130529	Vicugna pacos	39.80	7.00e-105	374.00
IUUC-Vvi-131059	Vitis vinifera	69.09	0.00e+00	709.00
IUUC-Xtr-132002	Xenopus tropicalis	41.65	1.00e-113	403.00
IUUC-Xma-133930	Xiphophorus maculatus	40.35	5.00e-111	394.00
IUUC-Yli-134505	Yarrowia lipolytica	32.34	6.00e-67	247.00
IUUC-Zma-135619	Zea mays	85.46	0.00e+00	827.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence