iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

mRNA Expression
GEO	FFGED
Protein-protein Interaction
IID	iRefIndex	HINT	Mentha
Protein 3D Structure
PDB	MMDB
Post-translational Modifications (PTMs)
CPLM	dbPAF	dbPTM	BioGRID
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	3.00e-29	98.3	347	379
UBD/Beta-Prp	2.50e-54	182.9	174	425

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlr 31
           gH+ +++ +a+ ++   +++G++Dg i vWD+r
   Q: 347  GHSKPIYTVAWsPNgYQVATGGGDGIINVWDIR 379
           8***********77688**************87 PP

UBD/Beta-Prp

   S: 9    hksvitcvkfspdksllatgsrdgtikvwdvtt.gkllrslsgheaevtavkfspdgk.ilvtgseDrtikvwdlstgkcvhtlk....ghedsvlslsfs 103
            +++i++v  s d+ ++atgs+ g ++v + +t + l ++l +h +++ a++++pd++  +++++eD++ik + +s+ +    l     ghe+++ +++++
   Q: 174  STKPISAVSLSTDDMVVATGSWAGDLQVLNSQTlQPLTQKLDSHVGKIGAIDWHPDSNnQMISCAEDGLIKNFQYSNEEGGLRLLgdlvGHERRISDVKYH 274
           57899*************************9883456999****************9999***************96654444443444************ PP
   S: 104  psgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtdsvyslsfdsngkelvsgsldgtv 204
           psg+++ s+shd t r+wd +t q+l  +++ghd+ v ++++++dg+l+ sG+ D+  +lWd+++g+ + tl g h +++y +++++ng ++++g+ dg +
   Q: 275  PSGKFIGSASHDMTWRLWDASTHQELL-LQEGHDKGVFSLSFQCDGSLVCSGGMDSLSMLWDIRSGSKVMTLAG-HSKPIYTVAWSPNGYQVATGGGDGII 373
           ***************************.********************************************99.************************** PP
   S: 205  klwdlq...tgecvrtlnghtdnvksvrfs..pnderlvsgssDgsiriWdlr 252
           ++wd++   +g  +++  +h++ v++vrfs  + ++ lvs++ D+ i+++ ++
   Q: 374  NVWDIRkrdEG-QLNQILAHRNIVTQVRFSkeDGGKKLVSCGYDNLINVYSSD 425
           ******77444.499999************98999**************9655 PP

Organism

Saccharomyces cerevisiae

Functional Description
(View)

Component of the U4/U6-U5 tri-snRNP complex composed of the U4, U6 and U5 snRNAs and at least PRP3, PRP4, PRP6, PRP8, PRP18, PRP31, PRP38, SNU13, SNU23, SNU66, SNU114, SPP381, SMB1, SMD1, SMD2, SMD3, SMX2, SMX3, LSM2, LSM3, LSM4, LSM5, LSM6, LSM7, LSM8, BRR2 and DIB1.

Protein Sequence
(Fasta)

MSKYIALENL PVDLQHKGAT QNESTADILK QLPHERLQAV LEKIPEEDLE VRRLLSILKK 60
PEVVENEDVQ QRRIRLAEIL MVDEIDLENI NNMENINGEE VDEEDDEDFF TPATSELIFA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGAGTAAAT ATATTGCACT TGAAAATCTT CCGGTAGATT TGCAACATAA AGGAGCTACA 60
CAAAATGAAA GCACCGCTGA TATACTGAAA CAGTTGCCAC ATGAACGATT ACAAGCTGTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0181--Complete proteome
KW-0507--mRNA processing
KW-0508--mRNA splicing
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0747--Spliceosome
KW-0853--WD repeat

Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR014906--PRP4-like
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00500--SFM
SM00320--WD40

Gene Ontology

GO:0005681--C:spliceosomal complex
GO:0046540--C:U4/U6 x U5 tri-snRNP complex
GO:0030621--F:U4 snRNA binding
GO:0017070--F:U6 snRNA binding
GO:0000398--P:mRNA splicing, via spliceosome
GO:0034247--P:snoRNA splicing

KEGG

sce:YPR178W

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000771	Aegilops tauschii	33.33	4.00e-57	213.00
IUUC-Aml-001737	Ailuropoda melanoleuca	33.63	1.00e-68	251.00
IUUC-Atr-002828	Amborella trichopoda	35.83	3.00e-59	220.00
IUUC-Apl-003723	Anas platyrhynchos	33.99	1.00e-70	258.00
IUUC-Aca-004972	Anolis carolinensis	34.15	2.00e-69	254.00
IUUC-Aly-006531	Arabidopsis lyrata	34.08	2.00e-50	191.00
IUUC-Ath-007367	Arabidopsis thaliana	32.03	1.00e-60	225.00
IUUC-Ago-007893	Ashbya gossypii	40.04	6.00e-86	308.00
IUUC-Acl-008236	Aspergillus clavatus	29.31	2.00e-61	227.00
IUUC-Afl-008522	Aspergillus flavus	29.42	2.00e-67	247.00
IUUC-Afu-008904	Aspergillus fumigatus	30.00	9.00e-65	239.00
IUUC-Ani-009198	Aspergillus nidulans	32.16	7.00e-69	252.00
IUUC-Ang-009662	Aspergillus niger	35.07	6.00e-69	252.00
IUUC-Aor-009881	Aspergillus oryzae	32.25	2.00e-66	244.00
IUUC-Ate-010333	Aspergillus terreus	30.95	2.00e-61	227.00
IUUC-Ame-011697	Astyanax mexicanus	35.03	5.00e-71	259.00
IUUC-Bgr-012254	Blumeria graminis	33.68	6.00e-76	276.00
IUUC-Bta-012615	Bos taurus	33.63	9.00e-69	252.00
IUUC-Bci-013720	Botrytis cinerea	33.73	1.00e-76	278.00
IUUC-Bdi-014302	Brachypodium distachyon	33.03	2.00e-61	228.00
IUUC-Bol-015594	Brassica oleracea	34.45	1.00e-51	195.00
IUUC-Bra-017465	Brassica rapa	34.17	1.00e-51	195.00
IUUC-Cel-018632	Caenorhabditis elegans	33.33	2.00e-59	221.00
IUUC-Cja-019747	Callithrix jacchus	33.63	9.00e-69	252.00
IUUC-Cfa-020288	Canis familiaris	33.63	8.00e-69	252.00
IUUC-Cpo-021440	Cavia porcellus	33.19	3.00e-67	247.00
IUUC-Cre-022716	Chlamydomonas reinhardtii	33.24	3.00e-51	193.00
IUUC-Csa-023139	Chlorocebus sabaeus	36.20	8.00e-61	224.00
IUUC-Cho-024481	Choloepus hoffmanni	34.29	2.00e-69	254.00
IUUC-Cin-025106	Ciona intestinalis	31.87	1.00e-65	242.00
IUUC-Csv-026087	Ciona savignyi	32.09	2.00e-63	234.00
IUUC-Cgl-026538	Colletotrichum gloeosporioides	32.73	7.00e-73	266.00
IUUC-Cne-026793	Cryptococcus neoformans	30.04	8.00e-61	225.00
IUUC-Dre-028723	Danio rerio	34.37	6.00e-70	256.00
IUUC-Dno-029299	Dasypus novemcinctus	33.85	2.00e-69	254.00
IUUC-Dse-031562	Dothistroma septosporum	29.78	1.00e-64	238.00
IUUC-Dme-031783	Drosophila melanogaster	35.57	9.00e-60	222.00
IUUC-Ete-032669	Echinops telfairi	33.77	5.00e-70	256.00
IUUC-Eca-033566	Equus caballus	33.63	1.00e-68	251.00
IUUC-Eeu-034524	Erinaceus europaeus	39.33	9.00e-49	185.00
IUUC-Fca-036215	Felis catus	33.63	9.00e-69	252.00
IUUC-Fal-037018	Ficedula albicollis	34.94	9.00e-61	225.00
IUUC-Fox-037936	Fusarium oxysporum	33.40	7.00e-67	246.00
IUUC-Fso-038366	Fusarium solani	34.33	7.00e-71	259.00
IUUC-Gmo-038966	Gadus morhua	39.53	2.00e-57	214.00
IUUC-Ggr-039942	Gaeumannomyces graminis	34.87	6.00e-66	243.00
IUUC-Gga-040797	Gallus gallus	33.99	1.00e-70	258.00
IUUC-Gac-042598	Gasterosteus aculeatus	37.12	2.00e-59	221.00
IUUC-Gma-044220	Glycine max	34.17	2.00e-56	211.00
IUUC-Ggo-044682	Gorilla gorilla	33.63	1.00e-68	251.00
IUUC-Hsa-045804	Homo sapiens	33.63	9.00e-69	252.00
IUUC-Hvu-047567	Hordeum vulgare	34.73	3.00e-55	207.00
IUUC-Itr-047882	Ictidomys tridecemlineatus	33.85	2.00e-69	254.00
IUUC-Kpa-049369	Komagataella pastoris	38.19	2.00e-68	251.00
IUUC-Lch-050074	Latimeria chalumnae	31.78	5.00e-61	226.00
IUUC-Lpe-051333	Leersia perrieri	32.94	5.00e-57	213.00
IUUC-Loc-052164	Lepisosteus oculatus	35.70	2.00e-71	261.00
IUUC-Lma-053088	Leptosphaeria maculans	31.24	5.00e-63	233.00
IUUC-Laf-053460	Loxodonta africana	33.63	7.00e-69	252.00
IUUC-Mcc-055859	Macaca mulatta	33.63	9.00e-69	252.00
IUUC-Meu-056134	Macropus eugenii	34.29	2.00e-69	254.00
IUUC-Mor-057251	Magnaporthe oryzae	33.48	7.00e-69	252.00
IUUC-Mpo-057375	Magnaporthe poae	42.06	3.00e-50	189.00
IUUC-Mtr-057656	Medicago truncatula	36.19	2.00e-53	201.00
IUUC-Mla-059145	Melampsora laricipopulina	39.14	2.00e-71	260.00
IUUC-Mga-059855	Meleagris gallopavo	33.99	8.00e-71	259.00
IUUC-Mvi-060372	Microbotryum violaceum	31.74	1.00e-57	215.00
IUUC-Mmr-060826	Microcebus murinus	33.85	7.00e-69	252.00
IUUC-Mdo-062748	Monodelphis domestica	34.07	3.00e-70	257.00
IUUC-Mmu-063351	Mus musculus	34.29	9.00e-69	252.00
IUUC-Mac-064846	Musa acuminata	35.18	5.00e-48	183.00
IUUC-Mpu-066006	Mustela putorius furo	33.63	9.00e-69	252.00
IUUC-Mlu-067722	Myotis lucifugus	33.63	9.00e-69	252.00
IUUC-Nfi-068399	Neosartorya fischeri	30.02	6.00e-67	246.00
IUUC-Ncr-068711	Neurospora crassa	33.27	1.00e-71	261.00
IUUC-Nle-069982	Nomascus leucogenys	33.63	9.00e-69	252.00
IUUC-Opr-070596	Ochotona princeps	33.63	1.00e-68	251.00
IUUC-Ont-072374	Oreochromis niloticus	37.09	5.00e-67	246.00
IUUC-Oan-073166	Ornithorhynchus anatinus	34.78	5.00e-63	232.00
IUUC-Ocu-074371	Oryctolagus cuniculus	33.63	8.00e-69	252.00
IUUC-Oba-075083	Oryza barthii	31.96	1.00e-56	211.00
IUUC-Obr-076405	Oryza brachyantha	32.95	3.00e-56	210.00
IUUC-Ogl-077683	Oryza glaberrima	31.96	2.00e-56	211.00
IUUC-Ogu-078486	Oryza glumaepatula	32.42	1.00e-56	212.00
IUUC-Oin-079679	Oryza indica	32.19	3.00e-59	221.00
IUUC-Olo-080243	Oryza longistaminata	34.73	6.00e-55	206.00
IUUC-Ome-081230	Oryza meridionalis	32.19	2.00e-59	221.00
IUUC-Oni-082961	Oryza nivara	32.19	2.00e-59	221.00
IUUC-Opu-083189	Oryza punctata	32.42	3.00e-57	213.00
IUUC-Oru-084353	Oryza rufipogon	32.40	1.00e-58	218.00
IUUC-Osa-085458	Oryza sativa	32.19	2.00e-59	221.00
IUUC-Ola-086940	Oryzias latipes	37.91	6.00e-66	243.00
IUUC-Olu-087580	Ostreococcus lucimarinus	29.54	1.00e-39	155.00
IUUC-Oga-088703	Otolemur garnettii	32.31	1.00e-61	228.00
IUUC-Oar-089829	Ovis aries	33.63	2.00e-69	254.00
IUUC-Ptr-090838	Pan troglodytes	33.63	9.00e-69	252.00
IUUC-Pan-092261	Papio anubis	33.55	2.00e-67	248.00
IUUC-Psi-093020	Pelodiscus sinensis	33.85	4.00e-71	260.00
IUUC-Pno-094858	Phaeosphaeria nodorum	34.72	5.00e-63	233.00
IUUC-Ppa-095531	Physcomitrella patens	31.99	1.00e-61	228.00
IUUC-Pfo-096812	Poecilia formosa	33.15	3.00e-49	187.00
IUUC-Pab-097805	Pongo abelii	35.60	9.00e-59	219.00
IUUC-Pop-100051	Populus trichocarpa	34.17	1.00e-55	208.00
IUUC-Pca-100152	Procavia capensis	33.63	7.00e-69	252.00
IUUC-Ppe-101244	Prunus persica	33.05	1.00e-57	215.00
IUUC-Pva-102529	Pteropus vampyrus	32.09	6.00e-62	229.00
IUUC-Pgr-103550	Puccinia graminis	32.86	4.00e-64	236.00
IUUC-Ptt-103951	Puccinia triticina	33.91	1.00e-53	202.00
IUUC-Pte-104151	Pyrenophora teres	33.93	7.00e-63	232.00
IUUC-Pyt-104571	Pyrenophora triticirepentis	34.45	2.00e-65	241.00
IUUC-Rno-105747	Rattus norvegicus	34.29	4.00e-69	253.00
IUUC-Sha-107334	Sarcophilus harrisii	34.29	2.00e-69	254.00
IUUC-Sja-107794	Schizosaccharomyces japonicus	32.15	7.00e-60	222.00
IUUC-Spo-108189	Schizosaccharomyces pombe	34.89	7.00e-64	236.00
IUUC-Ssl-108550	Sclerotinia sclerotiorum	34.74	3.00e-78	283.00
IUUC-Smo-109578	Selaginella moellendorffii	30.90	2.00e-64	238.00
IUUC-Sit-110102	Setaria italica	33.41	6.00e-60	223.00
IUUC-Sly-111668	Solanum lycopersicum	35.85	1.00e-62	231.00
IUUC-Stu-111928	Solanum tuberosum	35.85	1.00e-62	231.00
IUUC-Sar-113266	Sorex araneus	37.75	1.00e-59	221.00
IUUC-Sbi-114134	Sorghum bicolor	33.18	4.00e-59	220.00
IUUC-Sre-115114	Sporisorium reilianum	33.70	1.00e-60	224.00
IUUC-Ssc-115443	Sus scrofa	33.63	7.00e-69	252.00
IUUC-Tgu-117157	Taeniopygia guttata	34.21	1.00e-71	261.00
IUUC-Tru-118587	Takifugu rubripes	36.11	7.00e-69	252.00
IUUC-Tsy-119157	Tarsius syrichta	35.60	4.00e-64	236.00
IUUC-Tni-120427	Tetraodon nigroviridis	35.66	4.00e-70	256.00
IUUC-Tca-121368	Theobroma cacao	34.73	2.00e-59	221.00
IUUC-Tre-122074	Trichoderma reesei	33.40	3.00e-69	254.00
IUUC-Tvi-122349	Trichoderma virens	32.68	8.00e-69	252.00
IUUC-Tae-125651	Triticum aestivum	33.11	9.00e-58	215.00
IUUC-Tur-125983	Triticum urartu	35.83	4.00e-53	199.00
IUUC-Tme-126951	Tuber melanosporum	31.71	8.00e-73	265.00
IUUC-Tbe-128136	Tupaia belangeri	30.89	6.00e-60	223.00
IUUC-Ttr-129169	Tursiops truncatus	30.23	9.00e-30	122.00
IUUC-Uma-129399	Ustilago maydis	34.20	8.00e-64	235.00
IUUC-Vda-129842	Verticillium dahliae	33.07	1.00e-71	261.00
IUUC-Vpa-130440	Vicugna pacos	33.63	6.00e-69	253.00
IUUC-Vvi-131075	Vitis vinifera	34.73	2.00e-60	225.00
IUUC-Xma-133002	Xiphophorus maculatus	38.36	4.00e-61	226.00
IUUC-Yli-134569	Yarrowia lipolytica	34.90	3.00e-70	256.00
IUUC-Zma-135799	Zea mays	32.39	1.00e-55	209.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence