iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
microRNA	TRANSFAC	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha
Post-translational Modifications (PTMs)
CPLM	PhosphositePlus
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
ULD/UBL/SUMO	1.10e-32	112.9	14	92

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

ULD/UBL/SUMO

   S: 6    kapvslkvagqdGsevlfklklsaqlkklmeavYvkrinldensvrfvfngqkireqetpeelevededkiellcqksGG 85
             +++lkvagqdGs v+fk+k++++l+klm+a Y++r++l+++++rf+f+gq+i+e++tp++le+eded+i++++q++GG
   Q: 14   NDHINLKVAGQDGSVVQFKIKRHTPLSKLMKA-YCERQGLSMRQIRFRFDGQPINETDTPAQLEMEDEDTIDVFQQQTGG 92
           689*****************************.**********************************************9 PP

Organism

Rattus norvegicus

Functional Description
(View)

Ubiquitin-like protein which can be covalently attached to target lysines either as a monomer or as a lysine-linked polymer. Does not seem to be involved in protein degradation and may function as an antagonist of ubiquitin in the degradation process. Plays a role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Covalent attachment to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4. Plays a role in the regulation of sumoylation status of SETX (By similarity).

Protein Sequence
(Fasta)

MSEEKPKEGV KTENDHINLK VAGQDGSVVQ FKIKRHTPLS KLMKAYCERQ GLSMRQIRFR 60
FDGQPINETD TPAQLEMEDE DTIDVFQQQT GGTASRASVP TPSHFPDICY

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGGGCAGAGA GCGTGACTCG CCCGCTCCAG TGCCACCGGT TCCCGCTGCG CTTGCCGCCG 60
CCGTCGCCGC GCAACCATGT CGGAAGAGAA GCCCAAGGTA AGCCCGGTAC GCAAGACGCA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-1017--Isopeptide bond
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway

Interpro

IPR022617--Rad60/SUMO-like_dom
IPR033950--Sumo
IPR027218--SUMO_2/3
IPR029071--Ubiquitin-rel_dom
IPR000626--Ubiquitin_dom

PROSITE

PS50053--UBIQUITIN_2

Pfam

PF11976--Rad60-SLD

SMART

SM00213--UBQ

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0016605--C:PML body
GO:0031386--F:protein tag
GO:0016925--P:protein sumoylation

KEGG

rno:499417

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-001056	Aegilops tauschii	45.83	4.00e-17	79.70
IUUC-Aml-002090	Ailuropoda melanoleuca	97.78	1.00e-49	186.00
IUUC-Atr-002794	Amborella trichopoda	56.41	1.00e-20	90.50
IUUC-Aca-004778	Anolis carolinensis	100.00	3.00e-51	192.00
IUUC-Aly-005765	Arabidopsis lyrata	51.61	8.00e-22	94.70
IUUC-Ath-007391	Arabidopsis thaliana	49.48	6.00e-22	95.10
IUUC-Acl-008286	Aspergillus clavatus	50.00	2.00e-17	79.70
IUUC-Afl-008650	Aspergillus flavus	51.28	1.00e-17	80.90
IUUC-Afu-008969	Aspergillus fumigatus	50.00	2.00e-17	80.10
IUUC-Ani-009300	Aspergillus nidulans	48.72	2.00e-16	76.60
IUUC-Ang-009651	Aspergillus niger	51.28	4.00e-17	79.00
IUUC-Ate-010503	Aspergillus terreus	41.24	5.00e-15	72.40
IUUC-Ame-011304	Astyanax mexicanus	96.77	1.00e-50	190.00
IUUC-Bgr-012250	Blumeria graminis	47.50	4.00e-17	79.30
IUUC-Bta-012492	Bos taurus	98.92	1.00e-51	193.00
IUUC-Bci-013625	Botrytis cinerea	47.06	3.00e-18	82.80
IUUC-Bdi-014847	Brachypodium distachyon	53.33	1.00e-21	94.00
IUUC-Bol-015977	Brassica oleracea	50.00	3.00e-22	96.30
IUUC-Bra-017542	Brassica rapa	50.00	2.00e-22	96.70
IUUC-Cja-019875	Callithrix jacchus	96.74	3.00e-49	185.00
IUUC-Cpo-022241	Cavia porcellus	88.07	6.00e-54	201.00
IUUC-Cre-022980	Chlamydomonas reinhardtii	43.62	8.00e-19	84.70
IUUC-Csa-023587	Chlorocebus sabaeus	87.27	1.00e-52	197.00
IUUC-Dre-027877	Danio rerio	96.81	6.00e-51	191.00
IUUC-Dse-031390	Dothistroma septosporum	50.00	1.00e-20	90.50
IUUC-Dme-031967	Drosophila melanogaster	70.97	1.00e-33	134.00
IUUC-Fca-036348	Felis catus	87.50	2.00e-51	193.00
IUUC-Fox-037950	Fusarium oxysporum	49.44	3.00e-20	89.70
IUUC-Gmo-039393	Gadus morhua	96.77	1.00e-50	190.00
IUUC-Ggr-040015	Gaeumannomyces graminis	55.13	1.00e-20	90.90
IUUC-Gac-041576	Gasterosteus aculeatus	95.74	8.00e-51	191.00
IUUC-Hsa-046074	Homo sapiens	98.92	3.00e-51	192.00
IUUC-Hvu-047514	Hordeum vulgare	52.75	3.00e-21	92.80
IUUC-Itr-048366	Ictidomys tridecemlineatus	90.00	2.00e-54	203.00
IUUC-Kpa-049243	Komagataella pastoris	47.31	4.00e-13	65.90
IUUC-Lch-050519	Latimeria chalumnae	84.85	1.00e-45	174.00
IUUC-Lpe-051129	Leersia perrieri	56.67	3.00e-24	102.00
IUUC-Loc-052130	Lepisosteus oculatus	95.74	3.00e-50	189.00
IUUC-Lma-052968	Leptosphaeria maculans	47.19	2.00e-18	83.20
IUUC-Mor-057132	Magnaporthe oryzae	55.13	2.00e-20	90.10
IUUC-Mpo-057351	Magnaporthe poae	55.13	1.00e-20	90.50
IUUC-Mtr-057985	Medicago truncatula	51.65	3.00e-21	93.20
IUUC-Mla-059051	Melampsora laricipopulina	44.83	2.00e-15	73.90
IUUC-Mvi-060478	Microbotryum violaceum	42.31	6.00e-12	62.00
IUUC-Mmr-061052	Microcebus murinus	95.05	1.00e-51	194.00
IUUC-Mmu-064045	Mus musculus	92.04	6.00e-58	215.00
IUUC-Mac-064925	Musa acuminata	57.14	3.00e-20	90.10
IUUC-Mpu-065686	Mustela putorius furo	97.73	3.00e-48	182.00
IUUC-Mlu-066949	Myotis lucifugus	94.57	4.00e-47	178.00
IUUC-Nfi-068364	Neosartorya fischeri	50.00	2.00e-17	80.10
IUUC-Opr-071104	Ochotona princeps	30.00	3.00e-05	43.10
IUUC-Ont-071955	Oreochromis niloticus	98.91	1.00e-50	190.00
IUUC-Oan-073080	Ornithorhynchus anatinus	85.98	2.00e-50	190.00
IUUC-Oba-075425	Oryza barthii	58.97	2.00e-22	97.10
IUUC-Obr-076884	Oryza brachyantha	60.26	7.00e-23	98.20
IUUC-Ogl-077346	Oryza glaberrima	58.97	2.00e-22	97.10
IUUC-Ogu-078983	Oryza glumaepatula	53.33	3.00e-21	93.60
IUUC-Oin-079503	Oryza indica	58.97	2.00e-22	97.10
IUUC-Olo-080573	Oryza longistaminata	58.97	2.00e-22	97.10
IUUC-Ome-081885	Oryza meridionalis	58.97	2.00e-22	97.10
IUUC-Oni-082762	Oryza nivara	58.97	2.00e-22	97.10
IUUC-Opu-083431	Oryza punctata	58.75	2.00e-22	98.60
IUUC-Oru-084392	Oryza rufipogon	58.97	2.00e-22	97.10
IUUC-Osa-086070	Oryza sativa	58.97	2.00e-22	97.10
IUUC-Ola-086379	Oryzias latipes	95.83	1.00e-50	191.00
IUUC-Oga-088989	Otolemur garnettii	100.00	2.00e-51	192.00
IUUC-Oar-089406	Ovis aries	97.70	1.00e-47	180.00
IUUC-Ptr-091447	Pan troglodytes	98.92	3.00e-51	192.00
IUUC-Pno-094884	Phaeosphaeria nodorum	46.67	2.00e-19	86.70
IUUC-Ppa-095772	Physcomitrella patens	52.17	1.00e-20	90.90
IUUC-Pfo-097413	Poecilia formosa	96.81	1.00e-50	190.00
IUUC-Pop-099042	Populus trichocarpa	52.43	4.00e-21	92.40
IUUC-Ppe-102021	Prunus persica	52.17	3.00e-21	92.80
IUUC-Ptt-103986	Puccinia triticina	43.75	8.00e-15	71.60
IUUC-Pte-104358	Pyrenophora teres	47.78	5.00e-20	88.60
IUUC-Pyt-104485	Pyrenophora triticirepentis	47.78	5.00e-20	88.60
IUUC-Sha-106682	Sarcophilus harrisii	97.70	9.00e-48	180.00
IUUC-Smo-109229	Selaginella moellendorffii	50.00	2.00e-20	90.10
IUUC-Sly-110855	Solanum lycopersicum	54.43	1.00e-20	90.90
IUUC-Stu-112758	Solanum tuberosum	49.46	7.00e-21	91.70
IUUC-Ssc-116092	Sus scrofa	94.00	5.00e-51	191.00
IUUC-Tru-118409	Takifugu rubripes	95.79	2.00e-50	189.00
IUUC-Tni-120059	Tetraodon nigroviridis	95.74	4.00e-50	188.00
IUUC-Vvi-130844	Vitis vinifera	56.96	4.00e-21	93.20
IUUC-Xtr-132678	Xenopus tropicalis	90.48	9.00e-53	197.00
IUUC-Xma-133518	Xiphophorus maculatus	97.85	7.00e-51	191.00
IUUC-Zma-134810	Zea mays	51.49	4.00e-22	95.50

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence