iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
Protein-protein Interaction
iRefIndex	PINA	HINT	Mentha
Protein Expression/Proteomics

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/APC_C/CDC20	8.30e-141	469.5	162	462
E3 adaptor/Cullin RING/DCX/DWD	7.50e-24	83.7	296	330

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/APC_C/CDC20

   S: 1    pekvldapelrddfylnLldWssknvlavaLgssvylwsaktgdvskladleekdlvtsvswieegtllavGtkkgeveiyDveekkkvrtltghsar 98
           p+kvldap+l+ddfyln++dWss+nvlav+Lg++vylw a++++v+kl+dl ++d+v+sv+w++eg+++++Gt++g+v+++D +++k+vrt+ gh++r
   Q: 162  PHKVLDAPSLQDDFYLNVVDWSSQNVLAVGLGTCVYLWTASNSKVTKLCDLGPNDSVCSVQWTREGSYISIGTSHGQVQVWDGTQCKRVRTMGGHQTR 259
           689*********************************************************************************************** PP
   S: 99   vgaLsWnaevlssGsrdgeilhrdvrvkelklstlqahaqevCGlkwnedaklLasGGnDnsvsvwdasssePlkkfkehkaavkaiawsPwqkslLa 196
            g L+Wn+ +lssGsrd++il++d+rv+   +s+l +h++evCGlkw++d+++LasGGnDn++ vw+++s++P+ k +eh+aavkai+wsP+q+slLa
   Q: 260  TGVLAWNSRILSSGSRDRNILQHDIRVQSDFVSKLVGHKSEVCGLKWSHDDRELASGGNDNQLLVWNNHSQQPILKLTEHTAAVKAITWSPHQSSLLA 357
           ************************************************************************************************** PP
   S: 197  sGGGtaDrcikfwntltgalleeidtgsqvcsllwskkskelvsthGfaenkitlwkypslskvaelkgheaRvlslalspdgeaivtaagDetlrfw 294
           sGGGtaDrci+fwnt++g++l++idtgsqvc+l+wsk+ +e+vsthG+++n+i+lwkyps+skva+l+gh++Rvl+la spdg++ivt+agDetlrfw
   Q: 358  SGGGTADRCIRFWNTTNGNQLNSIDTGSQVCNLAWSKNVNEIVSTHGYSQNQIMLWKYPSMSKVATLTGHSMRVLYLATSPDGQTIVTGAGDETLRFW 455
           ************************************************************************************************** PP
   S: 295  klfdkkk 301
           ++f + k
   Q: 456  NVFPSVK 462
           ***7655 PP

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlrtg 33
           gH+++v++l++ +d + l+sG++D+++ vW+ +++
   Q: 296  GHKSEVCGLKWsHDdRELASGGNDNQLLVWNNHSQ 330
           8***********55599**************8776 PP

Organism

Arabidopsis thaliana

Functional Description
(View)

Activator protein that regulates the ubiquitin ligase activity and substrate specificity of the anaphase promoting complex/cyclosome (APC/C).

Protein Sequence
(Fasta)

MASPQSTKTG LNLPAGMNQT SLRLETFSSS FRGISSLSSP SKSTCSDRFI PCRSSSRLHA 60
FDLQDKEPTT PVKEGGNEAY SRLLKSELFG SDFASPLLSP AGGQGSASSP MSPCTNMLRF 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AAATGAAAAA AAAAAGAAAC AAAAAAAGTA GAAAAAGAGA GATAATTACA TCGATCTTCT 60
GCTCTTCCAA TTTGGCGGCG AGCTCCACTT TCTGTTCGGC AGTCATGTTT TCTAGAGAGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0131--Cell cycle
KW-0132--Cell division
KW-0181--Complete proteome
KW-0498--Mitosis
KW-1185--Reference proteome
KW-0677--Repeat
KW-0833--Ubl conjugation pathway
KW-0853--WD repeat

Interpro

IPR033010--Cdc20/Fizzy
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00400--WD40

SMART

SM00320--WD40

Gene Ontology

GO:0097027--F:ubiquitin-protein transferase activator activity
GO:0051301--P:cell division
GO:0007067--P:mitotic nuclear division
GO:1904668--P:positive regulation of ubiquitin protein ligase activity
GO:0016567--P:protein ubiquitination

KEGG

ath:AT5G13840

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Atr-003035	Amborella trichopoda	70.23	0.00e+00	639.00
IUUC-Aly-006009	Arabidopsis lyrata	98.54	0.00e+00	852.00
IUUC-Bdi-015033	Brachypodium distachyon	64.71	2.00e-177	614.00
IUUC-Bol-016159	Brassica oleracea	95.05	0.00e+00	814.00
IUUC-Bra-017745	Brassica rapa	94.03	0.00e+00	810.00
IUUC-Gma-043563	Glycine max	76.37	0.00e+00	696.00
IUUC-Hvu-047486	Hordeum vulgare	81.36	4.00e-150	523.00
IUUC-Lpe-051568	Leersia perrieri	69.98	4.00e-157	546.00
IUUC-Mtr-057760	Medicago truncatula	77.80	0.00e+00	708.00
IUUC-Mac-064942	Musa acuminata	73.28	0.00e+00	646.00
IUUC-Oba-075417	Oryza barthii	80.38	6.00e-155	540.00
IUUC-Obr-076033	Oryza brachyantha	72.95	8.00e-176	609.00
IUUC-Ogl-077441	Oryza glaberrima	68.98	2.00e-178	618.00
IUUC-Ogu-078877	Oryza glumaepatula	66.53	3.00e-168	583.00
IUUC-Oin-079461	Oryza indica	66.44	6.00e-167	579.00
IUUC-Olo-080716	Oryza longistaminata	70.73	2.00e-161	561.00
IUUC-Ome-081663	Oryza meridionalis	68.33	5.00e-171	593.00
IUUC-Oni-083097	Oryza nivara	66.73	8.00e-169	585.00
IUUC-Opu-083464	Oryza punctata	66.53	9.00e-168	582.00
IUUC-Oru-084848	Oryza rufipogon	66.73	8.00e-169	585.00
IUUC-Osa-085451	Oryza sativa	68.98	2.00e-178	618.00
IUUC-Pop-099269	Populus trichocarpa	79.72	0.00e+00	705.00
IUUC-Ppe-101285	Prunus persica	82.16	0.00e+00	718.00
IUUC-Sit-110550	Setaria italica	67.29	9.00e-177	612.00
IUUC-Sly-111395	Solanum lycopersicum	76.10	0.00e+00	703.00
IUUC-Stu-112356	Solanum tuberosum	76.29	0.00e+00	702.00
IUUC-Sbi-114386	Sorghum bicolor	74.54	7.00e-179	619.00
IUUC-Tsy-118931	Tarsius syrichta	40.61	1.00e-58	219.00
IUUC-Tca-121682	Theobroma cacao	81.41	0.00e+00	722.00
IUUC-Tae-123028	Triticum aestivum	73.29	3.00e-180	624.00
IUUC-Tur-126545	Triticum urartu	74.84	2.00e-137	481.00
IUUC-Vpa-130775	Vicugna pacos	38.83	7.00e-56	211.00
IUUC-Vvi-131748	Vitis vinifera	82.78	0.00e+00	740.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence