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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Mmu-063850
Ensembl Protein ID ENSMUSP00000072643.5
UniProt Accession Q8BH48; Q8BQ80; Q8BSW6; Q9D749; Q9ERV5; UBAP1_MOUSE
Genbank Protein ID AAG09810.3; BAC25970.1; BAC26057.1; BAB26382.1; BAC26927.1; BAC28160.1; BAC34609.1; BAC36165.1; AAH65996.1
Protein Name Ubiquitin-associated protein 1
Genbank Nucleotide ID AF275549; AK028477; AK028670; AK009596; AK030370; AK033121; AK051346; AK076078; BC065996
Gene Name Ubap1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000028437.14 ENSMUST00000072866.11 ENSMUSP00000072643.5
ENSMUSG00000028437.14 ENSMUST00000108060.9 ENSMUSP00000103695.3
ENSMUSG00000028437.14 ENSMUST00000132235.1 ENSMUSP00000123491.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
microRNATRANSFACRepTarmiRNAMap
RAID2
Protein-protein Interaction
IIDiRefIndexMentha
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
PHOSIDA
Protein Expression/Proteomics
GPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
UBD/Alpha-Helix/UBA UBA 11599797; 12050802
Classification
Family E-value Score Start End
UBD/Alpha-Helix/UBA 6.90e-15 55.8 459 496
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   UBD/Alpha-Helix/UBA
   S: 2    ededkleqlveMGFdreealqaLraannnleaAveyLl 39
           e+ +++ +++eMGF+ +++++ L+ +nn+ + A+e+L+
   Q: 459  EFLQLMSKFKEMGFELKDIKEVLLLHNNDQDNALEDLM 496
           667899******************************97 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Binds to ubiquitinated cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs). Plays a role in the proteasomal degradation of ubiquitinated cell-surface proteins, such as EGFR and BST2 (By similarity).
 Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Binds to ubiquitinated cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs). Plays a role in the proteasomal degradation of ubiquitinated cell-surface proteins, such as EGFR and BST2 (By similarity).
Protein Sequence
(Fasta)
MASKKLGTDV HGTFSYLDDV PFKIGDKFKT PAKVGLPIGF SLPDCLQVVR EMQYDFSLEK 60
KTIEWAEDIK LIQEAQREAE RKAEEAEAKV NSKSGPEGDS KVSFPKTHNT ATMPPPINPI 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-063850|UBD,UBA|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
TGATGTCAGA CGCCTAAAGG GGCGGAGCGT CGAGGGGAAG GAGGAGGGAA GTAGGCCTTC 60
AACATGGCGG CTGTGGTACT GGTGGTGGCT ACGGTGACGG TCTGGCTCGG GGCGGGTAGA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-063850|UBD,UBA|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0903--Direct protein sequencing
KW-0967--Endosome
KW-0597--Phosphoprotein
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0677--Repeat
KW-0813--Transport
Interpro

IPR015940--UBA
IPR009060--UBA-like
IPR023340--UMA
PROSITE

PS50030--UBA
PS51497--UMA
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0000813--C:ESCRT I complex
GO:0005794--C:Golgi apparatus
GO:0005886--C:plasma membrane
GO:0043130--F:ubiquitin binding
GO:0015031--P:protein transport
GO:0043162--P:ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
KEGG mmu:67123
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001255 Ailuropoda melanoleuca 90.48 0.00e+00 854.00
IUUC-Atr-003026 Amborella trichopoda 28.77 2.00e-04 38.90
IUUC-Apl-003392 Anas platyrhynchos 70.51 0.00e+00 664.00
IUUC-Aca-004360 Anolis carolinensis 67.45 4.00e-179 620.00
IUUC-Aly-006147 Arabidopsis lyrata 26.15 5.00e-04 38.10
IUUC-Ame-010979 Astyanax mexicanus 42.04 3.00e-81 295.00
IUUC-Bta-012720 Bos taurus 89.84 0.00e+00 838.00
IUUC-Bdi-014208 Brachypodium distachyon 33.33 8.00e-04 37.40
IUUC-Bra-016839 Brassica rapa 44.19 5.00e-03 35.80
IUUC-Cja-019955 Callithrix jacchus 91.04 0.00e+00 873.00
IUUC-Cfa-020433 Canis familiaris 88.01 4.00e-145 507.00
IUUC-Cpo-022043 Cavia porcellus 90.84 0.00e+00 880.00
IUUC-Csa-023905 Chlorocebus sabaeus 91.04 0.00e+00 851.00
IUUC-Cho-025098 Choloepus hoffmanni 88.67 0.00e+00 860.00
IUUC-Cin-025370 Ciona intestinalis 28.72 2.00e-07 50.40
IUUC-Dre-027667 Danio rerio 40.27 7.00e-74 271.00
IUUC-Dno-028980 Dasypus novemcinctus 89.46 0.00e+00 886.00
IUUC-Dor-030380 Dipodomys ordii 91.83 0.00e+00 890.00
IUUC-Dme-031880 Drosophila melanogaster 40.91 7.00e-03 35.40
IUUC-Ete-032657 Echinops telfairi 87.58 0.00e+00 753.00
IUUC-Eca-034094 Equus caballus 90.71 0.00e+00 871.00
IUUC-Eeu-034842 Erinaceus europaeus 90.12 0.00e+00 827.00
IUUC-Fca-036237 Felis catus 91.45 0.00e+00 852.00
IUUC-Fal-037011 Ficedula albicollis 71.95 0.00e+00 671.00
IUUC-Gmo-038530 Gadus morhua 72.41 8.00e-49 187.00
IUUC-Gga-040947 Gallus gallus 70.04 0.00e+00 650.00
IUUC-Gac-042101 Gasterosteus aculeatus 40.67 4.00e-86 311.00
IUUC-Gma-043886 Glycine max 31.37 4.00e-03 34.70
IUUC-Ggo-045459 Gorilla gorilla 91.43 0.00e+00 831.00
IUUC-Hsa-045873 Homo sapiens 91.04 0.00e+00 851.00
IUUC-Itr-048313 Ictidomys tridecemlineatus 93.43 0.00e+00 892.00
IUUC-Lch-050450 Latimeria chalumnae 52.80 1.00e-130 459.00
IUUC-Loc-052519 Lepisosteus oculatus 43.21 4.00e-82 298.00
IUUC-Laf-054397 Loxodonta africana 91.47 0.00e+00 877.00
IUUC-Mcc-055651 Macaca mulatta 91.53 0.00e+00 769.00
IUUC-Meu-056233 Macropus eugenii 83.66 0.00e+00 819.00
IUUC-Mtr-058776 Medicago truncatula 28.36 6.00e-04 37.40
IUUC-Mga-059888 Meleagris gallopavo 68.32 0.00e+00 640.00
IUUC-Mmr-061166 Microcebus murinus 92.46 0.00e+00 887.00
IUUC-Mdo-062565 Monodelphis domestica 81.33 0.00e+00 751.00
IUUC-Mac-065028 Musa acuminata 34.15 1.00e-03 36.60
IUUC-Mpu-066241 Mustela putorius furo 91.30 0.00e+00 870.00
IUUC-Mlu-068065 Myotis lucifugus 88.13 0.00e+00 848.00
IUUC-Nle-069682 Nomascus leucogenys 91.04 0.00e+00 852.00
IUUC-Opr-070846 Ochotona princeps 89.24 0.00e+00 876.00
IUUC-Ont-071429 Oreochromis niloticus 40.93 6.00e-78 284.00
IUUC-Oan-073014 Ornithorhynchus anatinus 96.15 2.00e-24 103.00
IUUC-Ocu-073955 Oryctolagus cuniculus 89.44 0.00e+00 880.00
IUUC-Obr-076832 Oryza brachyantha 34.09 7.00e-04 37.40
IUUC-Oin-080129 Oryza indica 33.33 1.00e-03 37.00
IUUC-Ola-087056 Oryzias latipes 39.88 3.00e-74 272.00
IUUC-Oga-088447 Otolemur garnettii 89.84 0.00e+00 858.00
IUUC-Oar-089849 Ovis aries 89.84 0.00e+00 836.00
IUUC-Ptr-091574 Pan troglodytes 91.04 0.00e+00 829.00
IUUC-Pan-092584 Papio anubis 90.84 0.00e+00 870.00
IUUC-Psi-093796 Pelodiscus sinensis 68.51 0.00e+00 653.00
IUUC-Pfo-096166 Poecilia formosa 40.67 1.00e-77 283.00
IUUC-Pab-098347 Pongo abelii 90.13 4.00e-146 510.00
IUUC-Pop-098804 Populus trichocarpa 26.74 4.00e-04 38.10
IUUC-Pca-100709 Procavia capensis 89.68 6.00e-119 421.00
IUUC-Pva-102428 Pteropus vampyrus 90.32 0.00e+00 885.00
IUUC-Rno-105514 Rattus norvegicus 95.22 0.00e+00 914.00
IUUC-Sha-107555 Sarcophilus harrisii 84.25 0.00e+00 815.00
IUUC-Stu-112785 Solanum tuberosum 26.47 2.00e-04 38.90
IUUC-Sar-113282 Sorex araneus 84.86 0.00e+00 628.00
IUUC-Ssc-116069 Sus scrofa 84.93 0.00e+00 717.00
IUUC-Tgu-116700 Taeniopygia guttata 72.02 0.00e+00 649.00
IUUC-Tru-117901 Takifugu rubripes 40.12 8.00e-77 281.00
IUUC-Tsy-119084 Tarsius syrichta 88.59 0.00e+00 653.00
IUUC-Tni-120603 Tetraodon nigroviridis 70.43 7.00e-47 181.00
IUUC-Tbe-127397 Tupaia belangeri 71.49 3.00e-177 614.00
IUUC-Ttr-128728 Tursiops truncatus 90.44 0.00e+00 828.00
IUUC-Vpa-130555 Vicugna pacos 90.22 0.00e+00 760.00
IUUC-Vvi-131340 Vitis vinifera 31.37 2.00e-04 38.90
IUUC-Xtr-132412 Xenopus tropicalis 58.33 5.00e-144 504.00
IUUC-Xma-133280 Xiphophorus maculatus 37.16 1.00e-58 220.00
IUUC-Yli-134514 Yarrowia lipolytica 32.50 2.00e-03 37.40
Created Date 25-Jun-2017

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