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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Rno-105416
Ensembl Protein ID ENSRNOP00000008944.4
UniProt Accession Q5U2M6; DCAF8_RAT
Genbank Protein ID AAH85957.1
Protein Name DDB1- and CUL4-associated factor 8; WD repeat-containing protein 42A
Genbank Nucleotide ID BC085957
Gene Name Dcaf8; Wdr42a
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSRNOG00000006785.7 ENSRNOT00000008944.7 ENSRNOP00000008944.4
ENSRNOG00000006785.7 ENSRNOT00000082469.1 ENSRNOP00000070721.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpress
DNA & RNA Element
microRNATRANSFACRAID2
Protein-protein Interaction
IID
Post-translational Modifications (PTMs)
dbPAFPhosphositePlusdbPTMUniProt
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 1.60e-22 79.1 185 216
UBD/Beta-Prp 6.00e-45 154.1 181 357
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 1    gHtdsvtclaf..sdtllvsGsdDgtikvWDl 30
           gHt+ v+ l+f   +t l+sGsdD ++ vWD+
   Q: 185  GHTGCVNTLHFnqRGTWLASGSDDLKVVVWDW 216
           8**********86559***************7 PP
   

   UBD/Beta-Prp
   S: 88   htlkghedsvlslsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdg..nllvsGslDrtvrlWdlktgkllrt 174
           h l+gh+  v +l+f++ g +l+sGs+d  + vwd+  +q + +++sgh++ v  +++ p++  + l+ ++ D++vr+  l+  ++ + 
   Q: 181  HGLEGHTGCVNTLHFNQRGTWLASGSDDLKVVVWDWVRRQPVLDFESGHKSNVFQAKFLPNSgdSTLAMCARDGQVRVAELSATQCCKN 269
           55566666666666666666666666666666666666666666666666666666665555555566666666666666655555444 PP
   S: 175  l..tgghtdsvyslsfdsng.kelvsgsldgtvklwdlq.....tgecvrtlnghtdnvksvrfs.pnderlvsgssDgsiriWdlrs 253
                +h+++ ++l++++++   ++s+++d  v   dl+     ++ +v + ++ +   + + +   n++ +++g+ D+ +ri+d r+
   Q: 270  TkrVAQHKGASHKLALEPDSpCTFLSAGEDAVVFTIDLRqdrpaSKLVVTKEKEKKVGLYTIYVNpANTHQFAVGGRDQFVRIYDQRK 357
           4442236666666666666633456666666666666665555444444444444444444444444555566666666666665444 PP
   
Organism Rattus norvegicus
Functional Description
(View)

Functional Description


     May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.
 May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.
Protein Sequence
(Fasta)
MSSKRPSTDG RRDLANGSLS SSPEEMSGAE EGRETSSGIE VEASDLSLSL TGDDGGPNRT 60
STESRGTDTE SSGEEKDSDS MEDTGHYSIN DENRVHGHSD EEEEEEQPRH RVQRKRASRD 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Rno-105416|E3,WD_repeat;UBD,Beta-Prp|Rattus norvegicus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GTGGACGGGG CGGCTGGGCC TGGAACAGTT GGAGCATCCG CTGGCAGAAG GATGACCCTA 60
GATGGGAAGC GGGCTGCCGG GCCTCGCCAG CTCCCGTGCT TGTAACTGCC CCAGCCGGAC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Rno-105416|E3,WD_repeat;UBD,Beta-Prp|Rattus norvegicus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0488--Methylation
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0833--Ubl conjugation pathway
KW-0853--WD repeat
Interpro

IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR017986--WD40_repeat_dom
PROSITE

PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF00400--WD40
SMART

SM00320--WD40
Gene Ontology

GO:0080008--C:Cul4-RING E3 ubiquitin ligase complex
GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0016567--P:protein ubiquitination
KEGG rno:364050
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000985 Aegilops tauschii 40.93 3.00e-83 302.00
IUUC-Aml-001810 Ailuropoda melanoleuca 95.81 0.00e+00 1056.00
IUUC-Atr-002578 Amborella trichopoda 43.37 8.00e-82 297.00
IUUC-Apl-003872 Anas platyrhynchos 67.73 8.00e-159 553.00
IUUC-Aca-004853 Anolis carolinensis 81.46 0.00e+00 902.00
IUUC-Aly-005505 Arabidopsis lyrata 41.30 3.00e-79 289.00
IUUC-Ath-007629 Arabidopsis thaliana 41.82 2.00e-77 283.00
IUUC-Ame-011615 Astyanax mexicanus 63.09 0.00e+00 695.00
IUUC-Bta-013549 Bos taurus 97.46 0.00e+00 1071.00
IUUC-Bdi-014538 Brachypodium distachyon 39.95 3.00e-74 272.00
IUUC-Bol-015797 Brassica oleracea 40.92 1.00e-76 280.00
IUUC-Bra-017142 Brassica rapa 41.19 9.00e-77 280.00
IUUC-Cja-018802 Callithrix jacchus 96.64 0.00e+00 1065.00
IUUC-Cfa-020535 Canis familiaris 96.14 0.00e+00 1060.00
IUUC-Cpo-022216 Cavia porcellus 96.79 0.00e+00 1067.00
IUUC-Cre-022883 Chlamydomonas reinhardtii 63.22 8.00e-29 122.00
IUUC-Csa-023095 Chlorocebus sabaeus 96.82 0.00e+00 1067.00
IUUC-Cho-024446 Choloepus hoffmanni 86.47 2.00e-141 495.00
IUUC-Cin-025683 Ciona intestinalis 57.72 1.00e-143 503.00
IUUC-Csv-026331 Ciona savignyi 57.78 1.00e-125 442.00
IUUC-Dre-027731 Danio rerio 64.64 0.00e+00 679.00
IUUC-Dno-029192 Dasypus novemcinctus 93.97 0.00e+00 1030.00
IUUC-Dse-031250 Dothistroma septosporum 50.00 2.00e-23 105.00
IUUC-Dme-032115 Drosophila melanogaster 42.66 3.00e-83 303.00
IUUC-Ete-032932 Echinops telfairi 86.36 0.00e+00 885.00
IUUC-Eca-034100 Equus caballus 96.48 0.00e+00 1064.00
IUUC-Fca-036138 Felis catus 95.14 0.00e+00 1052.00
IUUC-Fal-037132 Ficedula albicollis 96.46 3.00e-55 206.00
IUUC-Gmo-038895 Gadus morhua 78.16 0.00e+00 631.00
IUUC-Gga-040447 Gallus gallus 87.46 0.00e+00 923.00
IUUC-Gac-041796 Gasterosteus aculeatus 77.51 0.00e+00 674.00
IUUC-Gma-044062 Glycine max 40.41 2.00e-74 273.00
IUUC-Ggo-045613 Gorilla gorilla 97.42 0.00e+00 1045.00
IUUC-Hsa-046377 Homo sapiens 96.98 0.00e+00 1069.00
IUUC-Hvu-047687 Hordeum vulgare 42.74 4.00e-85 308.00
IUUC-Itr-048599 Ictidomys tridecemlineatus 91.37 0.00e+00 966.00
IUUC-Lch-050050 Latimeria chalumnae 67.29 0.00e+00 640.00
IUUC-Lpe-051191 Leersia perrieri 41.85 4.00e-81 295.00
IUUC-Laf-053407 Loxodonta africana 96.62 0.00e+00 1016.00
IUUC-Mcc-055604 Macaca mulatta 96.82 0.00e+00 1069.00
IUUC-Meu-056043 Macropus eugenii 89.24 0.00e+00 853.00
IUUC-Mtr-057813 Medicago truncatula 40.89 5.00e-81 295.00
IUUC-Mga-059697 Meleagris gallopavo 85.57 1.00e-166 578.00
IUUC-Mmr-061338 Microcebus murinus 97.15 0.00e+00 1070.00
IUUC-Mdo-062689 Monodelphis domestica 94.96 0.00e+00 971.00
IUUC-Mmu-063993 Mus musculus 98.14 0.00e+00 1078.00
IUUC-Mac-064558 Musa acuminata 40.30 4.00e-82 298.00
IUUC-Mpu-066622 Mustela putorius furo 95.30 0.00e+00 1058.00
IUUC-Mlu-067235 Myotis lucifugus 95.47 0.00e+00 995.00
IUUC-Nle-069048 Nomascus leucogenys 96.82 0.00e+00 1066.00
IUUC-Opr-070489 Ochotona princeps 80.34 4.00e-141 494.00
IUUC-Ont-072060 Oreochromis niloticus 77.40 0.00e+00 689.00
IUUC-Ocu-074684 Oryctolagus cuniculus 97.97 0.00e+00 1045.00
IUUC-Oba-075746 Oryza barthii 41.39 4.00e-84 305.00
IUUC-Obr-076629 Oryza brachyantha 42.07 4.00e-86 311.00
IUUC-Ogl-077243 Oryza glaberrima 43.12 1.00e-85 310.00
IUUC-Ogu-078029 Oryza glumaepatula 43.12 1.00e-85 310.00
IUUC-Oin-080109 Oryza indica 39.09 2.00e-73 269.00
IUUC-Olo-080308 Oryza longistaminata 41.97 5.00e-83 301.00
IUUC-Ome-081126 Oryza meridionalis 43.05 4.00e-83 301.00
IUUC-Oni-083114 Oryza nivara 43.12 6.00e-86 311.00
IUUC-Opu-083288 Oryza punctata 42.25 2.00e-83 302.00
IUUC-Oru-084724 Oryza rufipogon 43.12 1.00e-85 310.00
IUUC-Osa-085895 Oryza sativa 43.12 1.00e-85 310.00
IUUC-Olu-087847 Ostreococcus lucimarinus 29.86 9.00e-35 140.00
IUUC-Oga-088849 Otolemur garnettii 97.47 0.00e+00 1073.00
IUUC-Oar-089474 Ovis aries 93.93 0.00e+00 1011.00
IUUC-Ptr-091235 Pan troglodytes 96.98 0.00e+00 1069.00
IUUC-Pan-092895 Papio anubis 96.82 0.00e+00 1067.00
IUUC-Psi-093973 Pelodiscus sinensis 88.96 0.00e+00 961.00
IUUC-Ppa-095764 Physcomitrella patens 42.20 9.00e-85 307.00
IUUC-Pfo-097275 Poecilia formosa 78.07 0.00e+00 689.00
IUUC-Pab-098299 Pongo abelii 97.15 0.00e+00 1071.00
IUUC-Pop-099784 Populus trichocarpa 41.47 1.00e-78 286.00
IUUC-Pca-100729 Procavia capensis 91.28 0.00e+00 984.00
IUUC-Ppe-101712 Prunus persica 40.23 1.00e-78 287.00
IUUC-Pva-103030 Pteropus vampyrus 96.64 0.00e+00 1067.00
IUUC-Sha-106545 Sarcophilus harrisii 95.50 0.00e+00 986.00
IUUC-Smo-109128 Selaginella moellendorffii 46.37 2.00e-90 326.00
IUUC-Sit-110823 Setaria italica 40.68 4.00e-84 305.00
IUUC-Sly-111605 Solanum lycopersicum 38.61 1.00e-75 276.00
IUUC-Stu-111978 Solanum tuberosum 40.65 3.00e-81 295.00
IUUC-Sbi-114455 Sorghum bicolor 40.76 3.00e-79 289.00
IUUC-Ssc-115612 Sus scrofa 96.64 0.00e+00 1064.00
IUUC-Tru-117708 Takifugu rubripes 77.64 0.00e+00 691.00
IUUC-Tsy-119579 Tarsius syrichta 88.98 0.00e+00 744.00
IUUC-Tni-120739 Tetraodon nigroviridis 71.28 0.00e+00 704.00
IUUC-Tca-121555 Theobroma cacao 41.79 2.00e-79 289.00
IUUC-Tae-125509 Triticum aestivum 44.23 2.00e-86 313.00
IUUC-Tur-126617 Triticum urartu 41.26 7.00e-73 268.00
IUUC-Tbe-128115 Tupaia belangeri 94.94 0.00e+00 711.00
IUUC-Ttr-128231 Tursiops truncatus 91.28 0.00e+00 987.00
IUUC-Vpa-130377 Vicugna pacos 79.36 0.00e+00 865.00
IUUC-Vvi-131540 Vitis vinifera 40.75 3.00e-79 289.00
IUUC-Xtr-131860 Xenopus tropicalis 76.70 0.00e+00 816.00
IUUC-Xma-133371 Xiphophorus maculatus 77.88 0.00e+00 689.00
Created Date 25-Jun-2017

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