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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Mmu-063102
UUCD1 version UUC-MuM-00205
Ensembl Protein ID ENSMUSP00000026494.6
UniProt Accession E9QAU8; Q3UZA7; RN165_MOUSE
Genbank Protein ID BAE21950.1
Protein Name E3 ubiquitin-protein ligase RNF165; Arkadia-like protein 2C; RING finger protein 165
Genbank Nucleotide ID AC102135
Gene Name Rnf165; Ark2c; Gm96
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000025427.14 ENSMUST00000026494.13 ENSMUSP00000026494.6
ENSMUSG00000025427.14 ENSMUST00000182153.1 ENSMUSP00000138276.1
ENSMUSG00000025427.14 ENSMUST00000182146.1 ENSMUSP00000138529.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
miRTarBasemicroRNATRANSFACRAID2
Protein-protein Interaction
IID
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 activity/RING/RING 3.00e-07 32.0 295 336
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/RING
   S: 1    CaiCledfkdg..plvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C iCl++++dg  ++ lpC H+fh+ C+ +w         + +CP+Cr
   Q: 295  CTICLSMLEDGedVRRLPCMHLFHQLCVDQW------LAMSKKCPICR 336
           ********66555******************......999999****8 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     E3 ubiquitin-protein ligase that acts as a regulator of motor axon elongation (PubMed:23610558). Required for efficient motor axon extension in the dorsal forelimb by enhancing the transcriptional responses of the SMAD1/SMAD5/SMAD8 effectors, which are activated downstream of BMP (PubMed:23610558). Acts by mediating ubiquitination and degradation of SMAD inhibitors such as SMAD6, SMAD7, SKI and SNON isoform of SKIL (PubMed:23610558).
 E3 ubiquitin-protein ligase that acts as a regulator of motor axon elongation (PubMed:23610558). Required for efficient motor axon extension in the dorsal forelimb by enhancing the transcriptional responses of the SMAD1/SMAD5/SMAD8 effectors, which are activated downstream of BMP (PubMed:23610558). Acts by mediating ubiquitination and degradation of SMAD inhibitors such as SMAD6, SMAD7, SKI and SNON isoform of SKIL (PubMed:23610558).
Protein Sequence
(Fasta)
MVLVHVGYLV LPVFGSVRNR GAPFQRSQHP HATSCRHFHL GPPQPQQLAP DFPLAHPVQS 60
QPGLSAHMAP AHQHSGTLHQ SLTPLPTLQF QDVTGPSFLP QALHQQYLLQ QQLLEAQHRR 120
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Protein Fasta Sequence


>IUUC-Mmu-063102|E3,RING|Mus musculus
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Nucleotide Sequence
(Fasta)
ACAAAGGGCC CGCGCGCAGC CGCCGCCGCT GCGCGAGGAG CCAGGATGGT CCTGGTCCAC 60
GTCGGCTATC TCGTGCTTCC AGTGTTTGGC TCTGTGCGAA ACAGAGGTAT CGCTTTTTCC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-063102|E3,RING|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR001841--Znf_RING
IPR011016--Znf_RING-CH
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS50089--ZF_RING_2
Pfam

PF13639--zf-RING_2
SMART

SM00184--RING
SM00744--RINGv
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0043234--C:protein complex
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0007409--P:axonogenesis
GO:0035136--P:forelimb morphogenesis
GO:0060384--P:innervation
GO:0060173--P:limb development
GO:0008045--P:motor neuron axon guidance
GO:0010259--P:multicellular organism aging
GO:0061061--P:muscle structure development
GO:0030513--P:positive regulation of BMP signaling pathway
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0030163--P:protein catabolic process
GO:0000209--P:protein polyubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
KEGG mmu:225743
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000618 Aegilops tauschii 37.04 2.00e-14 74.70
IUUC-Aml-001791 Ailuropoda melanoleuca 98.54 4.00e-178 617.00
IUUC-Atr-003149 Amborella trichopoda 52.54 4.00e-16 76.30
IUUC-Apl-003783 Anas platyrhynchos 68.99 3.00e-121 427.00
IUUC-Aca-005299 Anolis carolinensis 85.23 3.00e-140 491.00
IUUC-Aly-005415 Arabidopsis lyrata 36.63 1.00e-16 80.10
IUUC-Ame-011948 Astyanax mexicanus 70.62 5.00e-129 454.00
IUUC-Bta-012470 Bos taurus 95.25 6.00e-167 579.00
IUUC-Bdi-014014 Brachypodium distachyon 37.07 1.00e-15 77.40
IUUC-Bol-016611 Brassica oleracea 36.11 7.00e-14 72.00
IUUC-Cel-018118 Caenorhabditis elegans 41.18 9.00e-16 78.20
IUUC-Cja-019798 Callithrix jacchus 94.24 2.00e-175 607.00
IUUC-Cfa-020297 Canis familiaris 97.69 1.00e-179 622.00
IUUC-Cpo-022225 Cavia porcellus 97.05 1.00e-179 622.00
IUUC-Csa-024018 Chlorocebus sabaeus 98.47 2.00e-174 604.00
IUUC-Cne-026985 Cryptococcus neoformans 39.05 2.00e-10 61.60
IUUC-Cme-027312 Cyanidioschyzon merolae 49.23 5.00e-13 68.60
IUUC-Dre-028365 Danio rerio 68.69 4.00e-104 370.00
IUUC-Dno-029962 Dasypus novemcinctus 94.63 1.00e-154 538.00
IUUC-Dor-030727 Dipodomys ordii 96.83 3.00e-180 624.00
IUUC-Eca-033911 Equus caballus 98.17 5.00e-169 586.00
IUUC-Fca-035641 Felis catus 98.25 8.00e-179 619.00
IUUC-Fal-037200 Ficedula albicollis 85.54 2.00e-143 501.00
IUUC-Gmo-039613 Gadus morhua 77.09 1.00e-86 312.00
IUUC-Gga-040277 Gallus gallus 86.67 8.00e-125 439.00
IUUC-Gac-042544 Gasterosteus aculeatus 63.20 8.00e-115 406.00
IUUC-Gma-044396 Glycine max 39.39 2.00e-15 77.80
IUUC-Ggo-044631 Gorilla gorilla 88.18 2.00e-176 610.00
IUUC-Hsa-046864 Homo sapiens 98.56 0.00e+00 645.00
IUUC-Hvu-047447 Hordeum vulgare 36.79 8.00e-15 74.70
IUUC-Itr-048602 Ictidomys tridecemlineatus 98.47 5.00e-176 609.00
IUUC-Lch-049656 Latimeria chalumnae 72.80 8.00e-110 390.00
IUUC-Lpe-050720 Leersia perrieri 34.34 7.00e-15 75.10
IUUC-Loc-052046 Lepisosteus oculatus 78.12 7.00e-144 503.00
IUUC-Laf-053554 Loxodonta africana 98.05 2.00e-83 301.00
IUUC-Mcc-055198 Macaca mulatta 98.47 2.00e-174 604.00
IUUC-Meu-055988 Macropus eugenii 83.44 2.00e-123 434.00
IUUC-Mtr-057649 Medicago truncatula 36.36 5.00e-14 73.20
IUUC-Mga-059245 Meleagris gallopavo 88.31 8.00e-75 271.00
IUUC-Mmr-061389 Microcebus murinus 98.56 4.00e-176 610.00
IUUC-Mdo-062317 Monodelphis domestica 94.80 4.00e-151 527.00
IUUC-Mac-065469 Musa acuminata 35.71 3.00e-15 76.30
IUUC-Mpu-066793 Mustela putorius furo 97.01 2.00e-165 575.00
IUUC-Nle-069235 Nomascus leucogenys 98.56 0.00e+00 642.00
IUUC-Opr-070646 Ochotona princeps 97.55 4.00e-162 563.00
IUUC-Ont-072005 Oreochromis niloticus 72.03 2.00e-119 422.00
IUUC-Oan-072924 Ornithorhynchus anatinus 76.42 3.00e-115 407.00
IUUC-Ocu-074718 Oryctolagus cuniculus 97.41 0.00e+00 639.00
IUUC-Oba-075466 Oryza barthii 33.33 4.00e-15 75.90
IUUC-Obr-076189 Oryza brachyantha 37.50 2.00e-14 73.60
IUUC-Ogl-076994 Oryza glaberrima 33.33 4.00e-15 75.90
IUUC-Ogu-078200 Oryza glumaepatula 33.33 4.00e-15 75.90
IUUC-Oin-079508 Oryza indica 33.33 4.00e-15 75.90
IUUC-Olo-080855 Oryza longistaminata 33.33 4.00e-15 75.90
IUUC-Ome-081841 Oryza meridionalis 33.33 4.00e-15 75.90
IUUC-Oni-082470 Oryza nivara 33.33 5.00e-15 75.50
IUUC-Oru-085181 Oryza rufipogon 33.33 4.00e-15 75.90
IUUC-Osa-086143 Oryza sativa 33.33 4.00e-15 75.90
IUUC-Ola-087143 Oryzias latipes 72.07 4.00e-120 424.00
IUUC-Olu-087774 Ostreococcus lucimarinus 42.59 6.00e-13 65.90
IUUC-Oga-087993 Otolemur garnettii 99.14 0.00e+00 653.00
IUUC-Oar-089588 Ovis aries 95.72 2.00e-163 567.00
IUUC-Ptr-091341 Pan troglodytes 98.56 0.00e+00 645.00
IUUC-Pan-091775 Papio anubis 98.56 0.00e+00 645.00
IUUC-Psi-092966 Pelodiscus sinensis 85.23 1.00e-137 482.00
IUUC-Ppa-095313 Physcomitrella patens 35.35 3.00e-14 74.30
IUUC-Pfo-096103 Poecilia formosa 68.84 1.00e-110 392.00
IUUC-Pop-099945 Populus trichocarpa 42.42 6.00e-15 76.30
IUUC-Ppe-101513 Prunus persica 40.40 4.00e-15 76.60
IUUC-Pva-102801 Pteropus vampyrus 92.80 9.00e-171 592.00
IUUC-Rno-105973 Rattus norvegicus 97.34 1.00e-177 615.00
IUUC-Sha-107027 Sarcophilus harrisii 91.28 3.00e-153 534.00
IUUC-Sja-107932 Schizosaccharomyces japonicus 50.98 4.00e-12 66.20
IUUC-Spo-108030 Schizosaccharomyces pombe 50.98 5.00e-11 62.80
IUUC-Smo-108847 Selaginella moellendorffii 34.29 2.00e-14 73.90
IUUC-Sit-110501 Setaria italica 34.29 1.00e-15 77.40
IUUC-Sly-111039 Solanum lycopersicum 41.41 7.00e-16 79.30
IUUC-Stu-112006 Solanum tuberosum 37.08 3.00e-11 63.90
IUUC-Sar-113383 Sorex araneus 96.32 7.00e-160 556.00
IUUC-Sbi-113906 Sorghum bicolor 58.33 8.00e-16 77.40
IUUC-Ssc-116357 Sus scrofa 88.86 9.00e-148 516.00
IUUC-Tgu-117345 Taeniopygia guttata 84.94 1.00e-142 499.00
IUUC-Tru-118756 Takifugu rubripes 70.59 1.00e-121 429.00
IUUC-Tni-120423 Tetraodon nigroviridis 69.38 3.00e-113 401.00
IUUC-Tca-121420 Theobroma cacao 37.37 2.00e-14 74.70
IUUC-Vpa-130177 Vicugna pacos 98.37 2.00e-101 360.00
IUUC-Vvi-130983 Vitis vinifera 34.65 5.00e-08 51.20
IUUC-Xtr-132317 Xenopus tropicalis 76.26 6.00e-116 410.00
IUUC-Xma-133967 Xiphophorus maculatus 69.77 6.00e-110 390.00
Created Date 25-Jun-2017

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