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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046763
UUCD1 version UUC-HoS-00223
Ensembl Protein ID ENSP00000322532.7
UniProt Accession Q8N2H9; Q8N3E1; Q8N9Q6; Q8TAW7; Q8TED5; PELI3_HUMAN
Genbank Protein ID AAO49465.1; AAO49466.1; BAB85015.1; BAC11499.1; BAC04275.1; CAD39057.1; AAH21256.1; AAH25723.1
Protein Name E3 ubiquitin-protein ligase pellino homolog 3; RING-type E3 ubiquitin transferase pellino homolog 3
Genbank Nucleotide ID AF487456; AF487457; AK074201; AK075253; AK094060; AL834395; BC021256; BC025723
Gene Name PELI3
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000174516.14 ENST00000349459.10 ENSP00000309848.8
ENSG00000174516.14 ENST00000320740.11 ENSP00000322532.7
ENSG00000174516.14 ENST00000524466.5 ENSP00000434677.1
ENSG00000174516.14 ENST00000618547.4 ENSP00000484220.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPA
DNA & RNA Element
UTRdbcircRNADbCircNetmiRTarBase
microRNATRANSFACTargetScanRepTar
miRcodeRAID2
Protein-protein Interaction
IIDPINAHINTMentha
InWeb_IM
Disease-associated Information
GWASdbOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusUniProt
BioGRID
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 activity/RING/RING RING 16884718
Classification
Family E-value Score Start End
E3 activity/RING/RING 4.8 9.4 415 449
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/RING
   S: 14   vlpCgHvfhadClqkw...pglknssskefrCPlC 45
           + pCgHv  ++    w   p+++     ++ CP C
   Q: 415  FAPCGHVCSEKTARYWaqtPLPHGTHAFHAACPFC 449
           489***9444444555999888888999999***9 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6. Mediates 'Lys-63'-linked polyubiquitination of IRAK1. Can activate AP1/JUN and ELK1. Not required for NF-kappa-B activation.
 E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6. Mediates 'Lys-63'-linked polyubiquitination of IRAK1. Can activate AP1/JUN and ELK1. Not required for NF-kappa-B activation.
Protein Sequence
(Fasta)
MVLEGNPEVG SPRTSDLQHR GNKGSCVLSS PGEDAQPGEE PIKYGELIVL GCCEEGGEET 60
EAQRGEVTGP RAHSCYNGCL ASGDKGRRRS RLALSRRSHA NGVKPDVMHH ISTPLVSKAL 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046763|E3,RING|Homo sapiens
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Nucleotide Sequence
(Fasta)
AGACAGGTCT GCGACTCTGG TCAACTGCAG CTGCTTTCCC CGGCCTCCAC CGCTGCCGCA 60
CACCCCCTTT GCCTTTAGCA TTTTCCTCCT CTCCTCTAAT TGCGTGGCGT CCCCAGATGG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046763|E3,RING|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
Interpro

IPR006800--Pellino_fam
IPR013083--Znf_RING/FYVE/PHD
Pfam

PF04710--Pellino
Gene Ontology

GO:0005829--C:cytosol
GO:0004674--F:protein serine/threonine kinase activity
GO:0061630--F:ubiquitin protein ligase activity
GO:0006955--P:immune response
GO:2001237--P:negative regulation of extrinsic apoptotic signaling pathway
GO:0010804--P:negative regulation of tumor necrosis factor-mediated signaling pathway
GO:0070534--P:protein K63-linked ubiquitination
GO:0008063--P:Toll signaling pathway
KEGG hsa:246330
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ani-009497 Aspergillus nidulans 45.71 1.30e-01 31.60
IUUC-Bta-012742 Bos taurus 98.29 0.00e+00 871.00
IUUC-Cja-019444 Callithrix jacchus 99.36 0.00e+00 857.00
IUUC-Cfa-021130 Canis familiaris 94.26 0.00e+00 841.00
IUUC-Dno-029295 Dasypus novemcinctus 98.51 0.00e+00 847.00
IUUC-Dor-031146 Dipodomys ordii 97.87 0.00e+00 862.00
IUUC-Eca-034003 Equus caballus 98.09 0.00e+00 863.00
IUUC-Ggo-045552 Gorilla gorilla 99.57 0.00e+00 859.00
IUUC-Mcc-055899 Macaca mulatta 99.57 0.00e+00 858.00
IUUC-Mmr-060623 Microcebus murinus 98.93 0.00e+00 878.00
IUUC-Nle-069909 Nomascus leucogenys 99.36 0.00e+00 855.00
IUUC-Opr-070627 Ochotona princeps 94.46 0.00e+00 807.00
IUUC-Oga-088275 Otolemur garnettii 97.25 0.00e+00 831.00
IUUC-Oar-090103 Ovis aries 95.31 0.00e+00 850.00
IUUC-Ptr-091182 Pan troglodytes 99.57 0.00e+00 859.00
IUUC-Pva-103049 Pteropus vampyrus 98.51 0.00e+00 874.00
IUUC-Sre-115102 Sporisorium reilianum 26.67 1.50e-01 32.30
IUUC-Ssc-115616 Sus scrofa 98.72 0.00e+00 852.00
IUUC-Tsy-119136 Tarsius syrichta 83.58 6.00e-178 616.00
IUUC-Tvi-122444 Trichoderma virens 38.10 2.60e+00 25.40
Created Date 25-Jun-2017

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