Mutation - TCGA Type Chromosome Start Position End Position Strand Variant Classification Variant Type Reference Allele Tumor_seq Allele 1 Tumor_seq Allele 2 Tumor Sample Barcode Matched Norm Sample Barcode Genome Change cDNA Change Codon Change Protein Change ACC 6 16145325 16145325 + Missense_Mutation SNP A A G TCGA-OR-A5J8-01A-11D-A29I-10 TCGA-OR-A5J8-10A-01D-A29L-10 g.chr6:16145325A>G c.1025A>G c.(1024-1026)aAc>aGc p.N342S ACC 6 16145408 16145408 + Nonsense_Mutation SNP C C T TCGA-OR-A5LJ-01A-11D-A29I-10 TCGA-OR-A5LJ-10A-01D-A29L-10 g.chr6:16145408C>T c.1108C>T c.(1108-1110)Cag>Tag p.Q370* BLCA 6 16141917 16141917 + Missense_Mutation SNP G G C TCGA-ZF-A9RL-01A-11D-A38G-08 TCGA-ZF-A9RL-10A-01D-A38J-08 g.chr6:16141917G>C c.340G>C c.(340-342)Gag>Cag p.E114Q BLCA 6 16143343 16143343 + Missense_Mutation SNP G G A TCGA-S5-A6DX-01A-11D-A31L-08 TCGA-S5-A6DX-10A-01D-A31J-08 g.chr6:16143343G>A c.557G>A c.(556-558)gGc>gAc p.G186D BLCA 6 16143376 16143376 + Missense_Mutation SNP G G A TCGA-XF-AAN0-01A-11D-A42E-08 TCGA-XF-AAN0-10A-01D-A42H-08 g.chr6:16143376G>A c.590G>A c.(589-591)gGg>gAg p.G197E BLCA 6 16144013 16144022 + Frame_Shift_Del DEL TCGTGCTCTT TCGTGCTCTT - TCGA-FD-A3SS-01A-12D-A22Z-08 TCGA-FD-A3SS-10A-01D-A22Z-08 g.chr6:16144013_16144022delTCGTGCTCTT c.746_755delTCGTGCTCTT c.(745-756)atcgtgctcttgfs p.IVLL249fs BLCA 6 16145390 16145390 + Missense_Mutation SNP G G A TCGA-ZF-AA5P-01A-11D-A391-08 TCGA-ZF-AA5P-10A-01D-A394-08 g.chr6:16145390G>A c.1090G>A c.(1090-1092)Gag>Aag p.E364K BLCA 6 16145428 16145428 + Silent SNP G G A TCGA-SY-A9G5-01A-11D-A38G-08 TCGA-SY-A9G5-10A-01D-A38J-08 g.chr6:16145428G>A c.1128G>A c.(1126-1128)gaG>gaA p.E376E BRCA 6 16143354 16143354 + Missense_Mutation SNP C C T TCGA-GM-A3NW-01A-21D-A228-09 TCGA-GM-A3NW-10A-01D-A22A-09 g.chr6:16143354C>T c.568C>T c.(568-570)Cat>Tat p.H190Y BRCA 6 16145378 16145378 + Missense_Mutation SNP T T A TCGA-D8-A1XS-01A-11D-A14K-09 TCGA-D8-A1XS-10A-01D-A14K-09 g.chr6:16145378T>A c.1078T>A c.(1078-1080)Tgc>Agc p.C360S COAD 6 16130860 16130860 + Missense_Mutation SNP T T G TCGA-CA-6717-01A-11D-1835-10 TCGA-CA-6717-10A-01D-1835-10 g.chr6:16130860T>G c.160T>G c.(160-162)Tta>Gta p.L54V COAD 6 16144086 16144086 + Silent SNP A A G TCGA-AA-3672-01A-01W-0900-09 TCGA-AA-3672-10A-01W-0900-09 g.chr6:16144086A>G c.819A>G c.(817-819)gcA>gcG p.A273A COAD 6 16145302 16145302 + Silent SNP C C T TCGA-AA-3984-01A-02W-0995-10 TCGA-AA-3984-10A-01W-0999-10 g.chr6:16145302C>T c.1002C>T c.(1000-1002)ggC>ggT p.G334G COAD 6 16145484 16145484 + Missense_Mutation SNP T T A TCGA-D5-6928-01A-11D-1924-10 TCGA-D5-6928-10A-01D-1924-10 g.chr6:16145484T>A c.1184T>A c.(1183-1185)aTc>aAc p.I395N COAD 6 16145533 16145533 + Silent SNP C C T TCGA-AA-3715-01A-01W-0900-09 TCGA-AA-3715-10A-01W-0900-09 g.chr6:16145533C>T c.1233C>T c.(1231-1233)tgC>tgT p.C411C COADREAD 6 16130860 16130860 + Missense_Mutation SNP T T G TCGA-CA-6717-01A-11D-1835-10 TCGA-CA-6717-10A-01D-1835-10 g.chr6:16130860T>G c.160T>G c.(160-162)Tta>Gta p.L54V COADREAD 6 16144086 16144086 + Silent SNP A A G TCGA-AA-3672-01A-01W-0900-09 TCGA-AA-3672-10A-01W-0900-09 g.chr6:16144086A>G c.819A>G c.(817-819)gcA>gcG p.A273A COADREAD 6 16145302 16145302 + Silent SNP C C T TCGA-AA-3984-01A-02W-0995-10 TCGA-AA-3984-10A-01W-0999-10 g.chr6:16145302C>T c.1002C>T c.(1000-1002)ggC>ggT p.G334G COADREAD 6 16145484 16145484 + Missense_Mutation SNP T T A TCGA-D5-6928-01A-11D-1924-10 TCGA-D5-6928-10A-01D-1924-10 g.chr6:16145484T>A c.1184T>A c.(1183-1185)aTc>aAc p.I395N COADREAD 6 16145533 16145533 + Silent SNP C C T TCGA-AA-3715-01A-01W-0900-09 TCGA-AA-3715-10A-01W-0900-09 g.chr6:16145533C>T c.1233C>T c.(1231-1233)tgC>tgT p.C411C ESCA 6 16129565 16129565 + Silent SNP T T C TCGA-LN-A49M-01A-21D-A27G-09 TCGA-LN-A49M-10A-01D-A27G-09 g.chr6:16129565T>C c.12T>C c.(10-12)taT>taC p.Y4Y ESCA 6 16130975 16130975 + Missense_Mutation SNP C C T TCGA-JY-A93E-01A-11D-A37C-09 TCGA-JY-A93E-10A-01D-A37F-09 g.chr6:16130975C>T c.275C>T c.(274-276)aCt>aTt p.T92I ESCA 6 16146915 16146915 + Missense_Mutation SNP G G A TCGA-2H-A9GI-01A-11D-A37C-09 TCGA-2H-A9GI-11A-11D-A37F-09 g.chr6:16146915G>A c.1271G>A c.(1270-1272)cGt>cAt p.R424H GBM 6 16130808 16130808 + Missense_Mutation SNP C C G TCGA-76-6282-01A-11D-1696-08 TCGA-76-6282-10A-01D-1696-08 g.chr6:16130808C>G c.108C>G c.(106-108)atC>atG p.I36M GBM 6 16130886 16130886 + Silent SNP C C T TCGA-76-6282-01A-11D-1696-08 TCGA-76-6282-10A-01D-1696-08 g.chr6:16130886C>T c.186C>T c.(184-186)atC>atT p.I62I GBM 6 16141881 16141881 + Missense_Mutation SNP G G C TCGA-28-5216-01A-01D-1486-08 TCGA-28-5216-10A-01D-1486-08 g.chr6:16141881G>C c.304G>C c.(304-306)Gag>Cag p.E102Q GBM 6 16143302 16143302 + Missense_Mutation SNP A A C TCGA-06-0743-01A-01D-1492-08 TCGA-06-0743-10A-01D-1492-08 g.chr6:16143302A>C c.516A>C c.(514-516)gaA>gaC p.E172D GBMLGG 6 16130808 16130808 + Missense_Mutation SNP C C G TCGA-76-6282-01A-11D-1696-08 TCGA-76-6282-10A-01D-1696-08 g.chr6:16130808C>G c.108C>G c.(106-108)atC>atG p.I36M GBMLGG 6 16130886 16130886 + Silent SNP C C T TCGA-76-6282-01A-11D-1696-08 TCGA-76-6282-10A-01D-1696-08 g.chr6:16130886C>T c.186C>T c.(184-186)atC>atT p.I62I GBMLGG 6 16141881 16141881 + Missense_Mutation SNP G G C TCGA-28-5216-01A-01D-1486-08 TCGA-28-5216-10A-01D-1486-08 g.chr6:16141881G>C c.304G>C c.(304-306)Gag>Cag p.E102Q GBMLGG 6 16143302 16143302 + Missense_Mutation SNP A A C TCGA-06-0743-01A-01D-1492-08 TCGA-06-0743-10A-01D-1492-08 g.chr6:16143302A>C c.516A>C c.(514-516)gaA>gaC p.E172D GBMLGG 6 16145221 16145221 + Silent SNP T T C TCGA-DU-6392-01A-11D-1705-08 TCGA-DU-6392-10A-01D-1705-08 g.chr6:16145221T>C c.921T>C c.(919-921)ctT>ctC p.L307L GBMLGG 6 16145386 16145386 + Silent SNP C C T TCGA-DU-6392-01A-11D-1705-08 TCGA-DU-6392-10A-01D-1705-08 g.chr6:16145386C>T c.1086C>T c.(1084-1086)agC>agT p.S362S HNSC 6 16141928 16141928 + Silent SNP G G T TCGA-CV-6961-01A-21D-1912-08 TCGA-CV-6961-10A-01D-1912-08 g.chr6:16141928G>T c.351G>T c.(349-351)gtG>gtT p.V117V HNSC 6 16143386 16143386 + Silent SNP G G T TCGA-CV-7089-01A-11D-2012-08 TCGA-CV-7089-10A-01D-2013-08 g.chr6:16143386G>T c.600G>T c.(598-600)ctG>ctT p.L200L KIPAN 6 16143330 16143330 + Missense_Mutation SNP A A G TCGA-HE-A5NH-01A-11D-A26P-10 TCGA-HE-A5NH-10A-01D-A26P-10 g.chr6:16143330A>G c.544A>G c.(544-546)Atg>Gtg p.M182V KIPAN 6 16146960 16146960 + Missense_Mutation SNP T T C TCGA-CW-5581-01A-02D-1534-10 TCGA-CW-5581-11A-01D-1535-10 g.chr6:16146960T>C c.1316T>C c.(1315-1317)cTt>cCt p.L439P KIRC 6 16146960 16146960 + Missense_Mutation SNP T T C TCGA-CW-5581-01A-02D-1534-10 TCGA-CW-5581-11A-01D-1535-10 g.chr6:16146960T>C c.1316T>C c.(1315-1317)cTt>cCt p.L439P KIRP 6 16143330 16143330 + Missense_Mutation SNP A A G TCGA-HE-A5NH-01A-11D-A26P-10 TCGA-HE-A5NH-10A-01D-A26P-10 g.chr6:16143330A>G c.544A>G c.(544-546)Atg>Gtg p.M182V LGG 6 16145221 16145221 + Silent SNP T T C TCGA-DU-6392-01A-11D-1705-08 TCGA-DU-6392-10A-01D-1705-08 g.chr6:16145221T>C c.921T>C c.(919-921)ctT>ctC p.L307L LGG 6 16145386 16145386 + Silent SNP C C T TCGA-DU-6392-01A-11D-1705-08 TCGA-DU-6392-10A-01D-1705-08 g.chr6:16145386C>T c.1086C>T c.(1084-1086)agC>agT p.S362S LIHC 6 16143347 16143347 + Silent SNP A A T TCGA-DD-AAW1-01A-11D-A40P-10 TCGA-DD-AAW1-10A-01D-A40P-10 g.chr6:16143347A>T c.561A>T c.(559-561)atA>atT p.I187I LIHC 6 16144041 16144041 + Silent SNP C C T TCGA-ES-A2HT-01A-12D-A183-10 TCGA-ES-A2HT-11A-11D-A183-10 g.chr6:16144041C>T c.774C>T c.(772-774)acC>acT p.T258T LIHC 6 16145305 16145305 + Silent SNP T T A TCGA-CC-A7IG-01A-11D-A33K-10 TCGA-CC-A7IG-10A-01D-A33K-10 g.chr6:16145305T>A c.1005T>A c.(1003-1005)gtT>gtA p.V335V LUAD 6 16130898 16130898 + Missense_Mutation SNP G G T TCGA-50-6594-01A-11D-1753-08 TCGA-50-6594-11A-01D-1753-08 g.chr6:16130898G>T c.198G>T c.(196-198)atG>atT p.M66I LUAD 6 16130937 16130937 + Missense_Mutation SNP G G T TCGA-55-5899-01A-11D-1625-08 TCGA-55-5899-10A-01D-1625-08 g.chr6:16130937G>T c.237G>T c.(235-237)aaG>aaT p.K79N LUAD 6 16143360 16143360 + Missense_Mutation SNP G G T TCGA-95-7043-01A-11D-1945-08 TCGA-95-7043-10A-01D-1946-08 g.chr6:16143360G>T c.574G>T c.(574-576)Gtg>Ttg p.V192L LUAD 6 16143378 16143378 + Nonsense_Mutation SNP C C T TCGA-67-3771-01A-01D-1040-01 TCGA-67-3771-10A-01D-1040-01 g.chr6:16143378C>T c.592C>T c.(592-594)Cag>Tag p.Q198* LUAD 6 16144081 16144081 + Missense_Mutation SNP C C G TCGA-78-7220-01A-11D-2036-08 TCGA-78-7220-10A-01D-2036-08 g.chr6:16144081C>G c.814C>G c.(814-816)Cac>Gac p.H272D LUAD 6 16145328 16145328 + Missense_Mutation SNP A A G TCGA-50-5946-01A-11D-1753-08 TCGA-50-5946-10A-01D-1753-08 g.chr6:16145328A>G c.1028A>G c.(1027-1029)aAc>aGc p.N343S LUAD 6 16145361 16145361 + Nonsense_Mutation SNP C C G TCGA-49-4487-01A-21D-1855-08 TCGA-49-4487-11A-01D-1855-08 g.chr6:16145361C>G c.1061C>G c.(1060-1062)tCa>tGa p.S354* LUAD 6 16145422 16145422 + Silent SNP G G A TCGA-69-7765-01A-11D-2167-08 TCGA-69-7765-10A-01D-2167-08 g.chr6:16145422G>A c.1122G>A c.(1120-1122)ctG>ctA p.L374L LUSC 6 16130818 16130818 + Missense_Mutation SNP G G A TCGA-39-5022-01A-21D-1817-08 TCGA-39-5022-11A-01D-1817-08 g.chr6:16130818G>A c.118G>A c.(118-120)Gac>Aac p.D40N LUSC 6 16144053 16144053 + Silent SNP C C T TCGA-22-1012-01A-01D-1521-08 TCGA-22-1012-11A-01D-1521-08 g.chr6:16144053C>T c.786C>T c.(784-786)agC>agT p.S262S LUSC 6 16145463 16145463 + Missense_Mutation SNP T T C TCGA-66-2773-01A-01D-1267-08 TCGA-66-2773-11A-01D-1267-08 g.chr6:16145463T>C c.1163T>C c.(1162-1164)aTg>aCg p.M388T OV 6 16145472 16145472 + Missense_Mutation SNP G G T TCGA-36-2534-01A-01D-1526-09 TCGA-36-2534-10A-01D-1526-09 g.chr6:16145472G>T c.1172G>T c.(1171-1173)tGc>tTc p.C391F PAAD 6 16141919 16141919 + Silent SNP G G A TCGA-IB-7651-01A-11D-2154-08 TCGA-IB-7651-10A-01D-2154-08 g.chr6:16141919G>A c.342G>A c.(340-342)gaG>gaA p.E114E PRAD 6 16143929 16143929 + Splice_Site SNP G G T TCGA-KK-A59V-01A-11D-A29Q-08 TCGA-KK-A59V-11A-11D-A29Q-08 g.chr6:16143929G>T c.e5-1 PRAD 6 16145318 16145318 + Missense_Mutation SNP T T C TCGA-CH-5767-01A-11D-1786-08 TCGA-CH-5767-11B-01D-1786-08 g.chr6:16145318T>C c.1018T>C c.(1018-1020)Tca>Cca p.S340P PRAD 6 16146916 16146916 + Silent SNP T T A TCGA-EJ-A46G-01A-31D-A26M-08 TCGA-EJ-A46G-10A-01D-A26K-08 g.chr6:16146916T>A c.1272T>A c.(1270-1272)cgT>cgA p.R424R SKCM 6 16141939 16141939 + Missense_Mutation SNP C C T TCGA-FW-A3R5-06A-11D-A23B-08 TCGA-FW-A3R5-10A-01D-A23B-08 g.chr6:16141939C>T c.362C>T c.(361-363)gCc>gTc p.A121V SKCM 6 16143273 16143273 + Silent SNP T T C TCGA-FS-A4F5-06A-11D-A25O-08 TCGA-FS-A4F5-10B-01D-A25O-08 g.chr6:16143273T>C c.487T>C c.(487-489)Ttg>Ctg p.L163L SKCM 6 16145341 16145341 + Silent SNP A A T TCGA-EE-A29S-06A-11D-A197-08 TCGA-EE-A29S-10A-01D-A199-08 g.chr6:16145341A>T c.1041A>T c.(1039-1041)tcA>tcT p.S347S SKCM 6 16145501 16145501 + Missense_Mutation SNP C C T TCGA-EE-A20H-06A-11D-A197-08 TCGA-EE-A20H-10A-01D-A199-08 g.chr6:16145501C>T c.1201C>T c.(1201-1203)Ccc>Tcc p.P401S

Mutation - ICGC Project Code Chromosome Chromosome Start Chromosome End Mutation Type Mutated from Allele Mutated to Allele Consequence Type AA Mutation CDS Mutation BLCA-US 6 16144013 16144022 deletion of <=200bp TCGTGCTCTT - frameshift_variant IVLL249 BLCA-US 6 16144013 16144022 deletion of <=200bp TCGTGCTCTT - frameshift_variant IVLL68 BRCA-EU 6 16124817 16124817 single base substitution G C upstream_gene_variant BRCA-EU 6 16125015 16125015 deletion of <=200bp T - upstream_gene_variant BRCA-EU 6 16126040 16126040 single base substitution T A upstream_gene_variant BRCA-EU 6 16126468 16126468 single base substitution G A upstream_gene_variant BRCA-EU 6 16126661 16126661 single base substitution G T upstream_gene_variant BRCA-EU 6 16127449 16127449 single base substitution G A upstream_gene_variant BRCA-EU 6 16129290 16129290 single base substitution C T upstream_gene_variant BRCA-EU 6 16129353 16129353 single base substitution C G upstream_gene_variant BRCA-EU 6 16129687 16129687 single base substitution G A intron_variant BRCA-EU 6 16130028 16130028 single base substitution A G intron_variant BRCA-EU 6 16130801 16130801 single base substitution T A intron_variant BRCA-EU 6 16130801 16130801 single base substitution T A missense_variant L34Q 101T>A BRCA-EU 6 16130898 16130898 single base substitution G T intron_variant BRCA-EU 6 16130898 16130898 single base substitution G T missense_variant M66I 198G>T BRCA-EU 6 16132227 16132227 single base substitution A C intron_variant BRCA-EU 6 16137345 16137346 deletion of <=200bp TT - intron_variant BRCA-EU 6 16139784 16139784 single base substitution G C intron_variant BRCA-EU 6 16140079 16140079 single base substitution G A intron_variant BRCA-EU 6 16140618 16140618 single base substitution T C intron_variant BRCA-EU 6 16140879 16140879 single base substitution A C intron_variant BRCA-EU 6 16141709 16141709 deletion of <=200bp T - intron_variant BRCA-EU 6 16143259 16143259 single base substitution C G 5_prime_UTR_variant BRCA-EU 6 16143259 16143259 single base substitution C G missense_variant A158G 473C>G BRCA-EU 6 16144575 16144575 single base substitution C G intron_variant BRCA-EU 6 16146643 16146643 single base substitution G A intron_variant BRCA-EU 6 16147811 16147811 single base substitution G A 3_prime_UTR_variant BRCA-EU 6 16147811 16147811 single base substitution G A downstream_gene_variant BRCA-EU 6 16147976 16147976 single base substitution G T 3_prime_UTR_variant BRCA-EU 6 16147976 16147976 single base substitution G T downstream_gene_variant BRCA-EU 6 16149802 16149802 single base substitution G T downstream_gene_variant BRCA-EU 6 16150133 16150133 single base substitution G T downstream_gene_variant BRCA-EU 6 16150827 16150827 single base substitution G A downstream_gene_variant BRCA-EU 6 16151579 16151579 single base substitution C G downstream_gene_variant BRCA-EU 6 16152703 16152703 single base substitution G C downstream_gene_variant BRCA-EU 6 16152790 16152790 single base substitution A G downstream_gene_variant BRCA-EU 6 16152966 16152966 single base substitution C T downstream_gene_variant BRCA-EU 6 16153314 16153314 single base substitution G C downstream_gene_variant BRCA-FR 6 16129290 16129290 single base substitution C T upstream_gene_variant BRCA-FR 6 16132405 16132405 single base substitution G A intron_variant BRCA-FR 6 16143696 16143696 single base substitution C G intron_variant BRCA-FR 6 16144575 16144575 single base substitution C G intron_variant BRCA-FR 6 16149970 16149970 single base substitution G T downstream_gene_variant BRCA-KR 6 16129610 16129610 single base substitution G A 5_prime_UTR_variant BRCA-KR 6 16129610 16129610 single base substitution G A synonymous_variant A19A 57G>A BRCA-UK 6 16143259 16143259 single base substitution C G 5_prime_UTR_variant BRCA-UK 6 16143259 16143259 single base substitution C G missense_variant A158G 473C>G BRCA-US 6 16143354 16143354 single base substitution C T missense_variant H190Y 568C>T BRCA-US 6 16143354 16143354 single base substitution C T missense_variant H9Y 25C>T BRCA-US 6 16145378 16145378 single base substitution T A missense_variant C179S 535T>A BRCA-US 6 16145378 16145378 single base substitution T A missense_variant C360S 1078T>A BTCA-JP 6 16145089 16145089 single base substitution T C intron_variant CLLE-ES 6 16147898 16147898 single base substitution G T 3_prime_UTR_variant CLLE-ES 6 16147898 16147898 single base substitution G T downstream_gene_variant COAD-US 6 16130860 16130860 single base substitution T G intron_variant COAD-US 6 16130860 16130860 single base substitution T G missense_variant L54V 160T>G COAD-US 6 16145473 16145473 single base substitution C T synonymous_variant C210C 630C>T COAD-US 6 16145473 16145473 single base substitution C T synonymous_variant C391C 1173C>T COAD-US 6 16145484 16145484 single base substitution T A missense_variant I214N 641T>A COAD-US 6 16145484 16145484 single base substitution T A missense_variant I395N 1184T>A COCA-CN 6 16141877 16141877 single base substitution C T 5_prime_UTR_variant COCA-CN 6 16141877 16141877 single base substitution C T synonymous_variant I100I 300C>T COCA-CN 6 16143371 16143371 single base substitution C T synonymous_variant S14S 42C>T COCA-CN 6 16143371 16143371 single base substitution C T synonymous_variant S195S 585C>T COCA-CN 6 16147349 16147349 single base substitution T C 3_prime_UTR_variant COCA-CN 6 16147349 16147349 single base substitution T C downstream_gene_variant ESAD-UK 6 16124556 16124556 single base substitution G A upstream_gene_variant ESAD-UK 6 16125991 16125991 insertion of <=200bp - A upstream_gene_variant ESAD-UK 6 16128065 16128065 single base substitution T C upstream_gene_variant ESAD-UK 6 16132176 16132176 insertion of <=200bp - A intron_variant ESAD-UK 6 16132802 16132802 single base substitution T G intron_variant ESAD-UK 6 16132923 16132923 single base substitution G T intron_variant ESAD-UK 6 16136777 16136777 insertion of <=200bp - T intron_variant ESAD-UK 6 16137412 16137412 single base substitution G C intron_variant ESAD-UK 6 16137867 16137867 single base substitution C G intron_variant ESAD-UK 6 16139268 16139268 single base substitution G A intron_variant ESAD-UK 6 16143458 16143458 single base substitution G C intron_variant ESAD-UK 6 16145120 16145120 single base substitution C T splice_region_variant ESAD-UK 6 16145266 16145266 single base substitution G A synonymous_variant V141V 423G>A ESAD-UK 6 16145266 16145266 single base substitution G A synonymous_variant V322V 966G>A ESAD-UK 6 16145518 16145518 single base substitution G A synonymous_variant V225V 675G>A ESAD-UK 6 16145518 16145518 single base substitution G A synonymous_variant V406V 1218G>A ESAD-UK 6 16146941 16146941 deletion of <=200bp C - frameshift_variant L252 ESAD-UK 6 16146941 16146941 deletion of <=200bp C - frameshift_variant L433 ESAD-UK 6 16147417 16147417 single base substitution G T 3_prime_UTR_variant ESAD-UK 6 16147417 16147417 single base substitution G T downstream_gene_variant ESAD-UK 6 16152425 16152425 single base substitution C T downstream_gene_variant ESCA-CN 6 16147449 16147449 single base substitution A T 3_prime_UTR_variant ESCA-CN 6 16147449 16147449 single base substitution A T downstream_gene_variant GBM-US 6 16130808 16130808 single base substitution C G intron_variant GBM-US 6 16130808 16130808 single base substitution C G missense_variant I36M 108C>G GBM-US 6 16130886 16130886 single base substitution C T intron_variant GBM-US 6 16130886 16130886 single base substitution C T synonymous_variant I62I 186C>T GBM-US 6 16141881 16141881 single base substitution G C 5_prime_UTR_variant GBM-US 6 16141881 16141881 single base substitution G C missense_variant E102Q 304G>C GBM-US 6 16143302 16143302 single base substitution A C 5_prime_UTR_variant GBM-US 6 16143302 16143302 single base substitution A C missense_variant E172D 516A>C KIRC-US 6 16146960 16146960 single base substitution T C missense_variant L258P 773T>C KIRC-US 6 16146960 16146960 single base substitution T C missense_variant L439P 1316T>C KIRP-US 6 16143330 16143330 single base substitution A G missense_variant M182V 544A>G KIRP-US 6 16143330 16143330 single base substitution A G start_lost M1V 1A>G LAML-KR 6 16128558 16128558 single base substitution T C upstream_gene_variant LAML-KR 6 16143864 16143864 single base substitution A G intron_variant LAML-KR 6 16151587 16151587 single base substitution C A downstream_gene_variant LICA-FR 6 16135979 16135979 single base substitution C T intron_variant LICA-FR 6 16145166 16145166 single base substitution G A missense_variant S108N 323G>A LICA-FR 6 16145166 16145166 single base substitution G A missense_variant S289N 866G>A LIHC-US 6 16145168 16145168 single base substitution C A missense_variant R109S 325C>A LIHC-US 6 16145168 16145168 single base substitution C A missense_variant R290S 868C>A LIHC-US 6 16145305 16145305 single base substitution T A synonymous_variant V154V 462T>A LIHC-US 6 16145305 16145305 single base substitution T A synonymous_variant V335V 1005T>A LINC-JP 6 16128106 16128106 single base substitution G C upstream_gene_variant LINC-JP 6 16136720 16136720 single base substitution A C intron_variant LINC-JP 6 16150230 16150230 single base substitution C G downstream_gene_variant LIRI-JP 6 16124419 16124419 single base substitution G T upstream_gene_variant LIRI-JP 6 16124779 16124779 single base substitution G A upstream_gene_variant LIRI-JP 6 16125039 16125039 single base substitution A C upstream_gene_variant LIRI-JP 6 16126320 16126320 single base substitution G T upstream_gene_variant LIRI-JP 6 16128448 16128448 single base substitution A C upstream_gene_variant LIRI-JP 6 16134074 16134074 single base substitution C A intron_variant LIRI-JP 6 16135455 16135455 single base substitution G A intron_variant LIRI-JP 6 16136338 16136338 single base substitution A G intron_variant LIRI-JP 6 16149812 16149812 single base substitution A G downstream_gene_variant LUSC-KR 6 16124684 16124684 single base substitution G T upstream_gene_variant LUSC-KR 6 16126080 16126080 single base substitution G C upstream_gene_variant LUSC-KR 6 16126275 16126275 single base substitution G T upstream_gene_variant LUSC-KR 6 16127505 16127505 single base substitution C T upstream_gene_variant LUSC-KR 6 16128981 16128981 single base substitution G A upstream_gene_variant LUSC-KR 6 16130854 16130854 single base substitution G T intron_variant LUSC-KR 6 16130854 16130854 single base substitution G T stop_gained E52* 154G>T LUSC-KR 6 16137575 16137575 single base substitution G A intron_variant LUSC-KR 6 16137944 16137944 single base substitution T G intron_variant LUSC-KR 6 16147470 16147470 single base substitution G A 3_prime_UTR_variant LUSC-KR 6 16147470 16147470 single base substitution G A downstream_gene_variant LUSC-KR 6 16151621 16151621 single base substitution C A downstream_gene_variant LUSC-KR 6 16152046 16152046 single base substitution A T downstream_gene_variant LUSC-KR 6 16153140 16153140 single base substitution G T downstream_gene_variant LUSC-US 6 16130818 16130818 single base substitution G A intron_variant LUSC-US 6 16130818 16130818 single base substitution G A missense_variant D40N 118G>A LUSC-US 6 16144053 16144053 single base substitution C T synonymous_variant S262S 786C>T LUSC-US 6 16144053 16144053 single base substitution C T synonymous_variant S81S 243C>T LUSC-US 6 16145463 16145463 single base substitution T C missense_variant M207T 620T>C LUSC-US 6 16145463 16145463 single base substitution T C missense_variant M388T 1163T>C MALY-DE 6 16125459 16125459 single base substitution T G upstream_gene_variant MALY-DE 6 16128936 16128936 single base substitution G A upstream_gene_variant MALY-DE 6 16129008 16129008 single base substitution G A upstream_gene_variant MALY-DE 6 16130654 16130654 single base substitution T C intron_variant MALY-DE 6 16130661 16130661 single base substitution T G intron_variant MALY-DE 6 16131539 16131539 single base substitution T A intron_variant MALY-DE 6 16136962 16136962 single base substitution T C intron_variant MALY-DE 6 16142304 16142304 single base substitution G A intron_variant MALY-DE 6 16148583 16148583 single base substitution T A downstream_gene_variant MALY-DE 6 16148631 16148631 single base substitution T C downstream_gene_variant MELA-AU 6 16124518 16124518 single base substitution C T upstream_gene_variant MELA-AU 6 16124901 16124901 single base substitution G A upstream_gene_variant MELA-AU 6 16125178 16125178 single base substitution G A upstream_gene_variant MELA-AU 6 16125416 16125416 single base substitution G A upstream_gene_variant MELA-AU 6 16125607 16125607 single base substitution C A upstream_gene_variant MELA-AU 6 16125732 16125732 single base substitution C T upstream_gene_variant MELA-AU 6 16125786 16125786 single base substitution C T upstream_gene_variant MELA-AU 6 16125972 16125972 single base substitution G A upstream_gene_variant MELA-AU 6 16126107 16126107 single base substitution G A upstream_gene_variant MELA-AU 6 16126278 16126278 single base substitution G A upstream_gene_variant MELA-AU 6 16126318 16126318 single base substitution C T upstream_gene_variant MELA-AU 6 16126388 16126388 single base substitution G A upstream_gene_variant MELA-AU 6 16126483 16126483 single base substitution G A upstream_gene_variant MELA-AU 6 16126947 16126947 single base substitution C T upstream_gene_variant MELA-AU 6 16126978 16126978 single base substitution C T upstream_gene_variant MELA-AU 6 16127003 16127003 single base substitution T A upstream_gene_variant MELA-AU 6 16127065 16127065 single base substitution C T upstream_gene_variant MELA-AU 6 16127197 16127197 single base substitution G A upstream_gene_variant MELA-AU 6 16127424 16127424 single base substitution G A upstream_gene_variant MELA-AU 6 16127760 16127760 single base substitution G A upstream_gene_variant MELA-AU 6 16128050 16128050 single base substitution A G upstream_gene_variant MELA-AU 6 16128079 16128079 single base substitution C T upstream_gene_variant MELA-AU 6 16128776 16128776 single base substitution T A upstream_gene_variant MELA-AU 6 16129200 16129200 single base substitution G A upstream_gene_variant MELA-AU 6 16129225 16129225 single base substitution G A upstream_gene_variant MELA-AU 6 16129240 16129240 single base substitution G A upstream_gene_variant MELA-AU 6 16129258 16129258 single base substitution G A upstream_gene_variant MELA-AU 6 16129300 16129300 single base substitution C T upstream_gene_variant MELA-AU 6 16129457 16129457 single base substitution C T 5_prime_UTR_variant MELA-AU 6 16130685 16130685 single base substitution T A intron_variant MELA-AU 6 16133549 16133549 single base substitution C T intron_variant MELA-AU 6 16134371 16134371 single base substitution A T intron_variant MELA-AU 6 16134692 16134692 single base substitution C T intron_variant MELA-AU 6 16135204 16135204 single base substitution A C intron_variant MELA-AU 6 16135216 16135216 single base substitution G A intron_variant MELA-AU 6 16135494 16135494 single base substitution C T intron_variant MELA-AU 6 16135540 16135540 single base substitution A G intron_variant MELA-AU 6 16135569 16135569 single base substitution T G intron_variant MELA-AU 6 16135986 16135986 single base substitution C A intron_variant MELA-AU 6 16136336 16136336 single base substitution C T intron_variant MELA-AU 6 16137668 16137668 single base substitution G A intron_variant MELA-AU 6 16137824 16137824 single base substitution A G intron_variant MELA-AU 6 16139674 16139674 single base substitution C T intron_variant MELA-AU 6 16139761 16139761 single base substitution C T intron_variant MELA-AU 6 16140120 16140120 single base substitution C T intron_variant MELA-AU 6 16142032 16142032 single base substitution C T 5_prime_UTR_variant MELA-AU 6 16142032 16142032 single base substitution C T missense_variant T152I 455C>T MELA-AU 6 16144054 16144054 single base substitution G A missense_variant G263R 787G>A MELA-AU 6 16144054 16144054 single base substitution G A missense_variant G82R 244G>A MELA-AU 6 16144832 16144832 single base substitution C T intron_variant MELA-AU 6 16145148 16145148 single base substitution C T missense_variant A102V 305C>T MELA-AU 6 16145148 16145148 single base substitution C T missense_variant A283V 848C>T MELA-AU 6 16145967 16145967 single base substitution C T intron_variant MELA-AU 6 16146213 16146213 single base substitution G A intron_variant MELA-AU 6 16146919 16146920 multiple base substitution (>=2bp and <=200bp) GG AA missense_variant VE244VK MELA-AU 6 16146919 16146920 multiple base substitution (>=2bp and <=200bp) GG AA missense_variant VE425VK MELA-AU 6 16147218 16147218 single base substitution C T 3_prime_UTR_variant MELA-AU 6 16147218 16147218 single base substitution C T downstream_gene_variant MELA-AU 6 16148001 16148001 single base substitution T G 3_prime_UTR_variant MELA-AU 6 16148001 16148001 single base substitution T G downstream_gene_variant MELA-AU 6 16148051 16148051 single base substitution C T 3_prime_UTR_variant MELA-AU 6 16148051 16148051 single base substitution C T downstream_gene_variant MELA-AU 6 16148140 16148140 single base substitution T C 3_prime_UTR_variant MELA-AU 6 16148140 16148140 single base substitution T C downstream_gene_variant MELA-AU 6 16148597 16148597 single base substitution T C downstream_gene_variant MELA-AU 6 16149924 16149924 single base substitution C T downstream_gene_variant MELA-AU 6 16150074 16150074 single base substitution C T downstream_gene_variant MELA-AU 6 16150106 16150106 single base substitution G A downstream_gene_variant MELA-AU 6 16150855 16150855 single base substitution G A downstream_gene_variant MELA-AU 6 16151071 16151071 single base substitution C T downstream_gene_variant MELA-AU 6 16151255 16151255 single base substitution C T downstream_gene_variant MELA-AU 6 16151280 16151280 single base substitution C T downstream_gene_variant MELA-AU 6 16152937 16152937 single base substitution C T downstream_gene_variant MELA-AU 6 16152999 16152999 single base substitution G A downstream_gene_variant MELA-AU 6 16153403 16153403 single base substitution A T downstream_gene_variant ORCA-IN 6 16148833 16148833 single base substitution C T downstream_gene_variant OV-AU 6 16126651 16126651 single base substitution C T upstream_gene_variant OV-AU 6 16127332 16127332 single base substitution C T upstream_gene_variant OV-AU 6 16129261 16129261 single base substitution C A upstream_gene_variant OV-AU 6 16132029 16132029 single base substitution A C intron_variant OV-AU 6 16141879 16141879 single base substitution A T 5_prime_UTR_premature_start_codon_gain_variant OV-AU 6 16141879 16141879 single base substitution A T missense_variant K101M 302A>T OV-AU 6 16145082 16145082 single base substitution G A intron_variant OV-AU 6 16145221 16145221 single base substitution T G synonymous_variant L126L 378T>G OV-AU 6 16145221 16145221 single base substitution T G synonymous_variant L307L 921T>G OV-AU 6 16146112 16146112 single base substitution G A intron_variant OV-AU 6 16146545 16146545 single base substitution A G intron_variant OV-AU 6 16147878 16147878 single base substitution G A 3_prime_UTR_variant OV-AU 6 16147878 16147878 single base substitution G A downstream_gene_variant PACA-AU 6 16130540 16130540 single base substitution G C intron_variant PACA-AU 6 16133774 16133774 single base substitution G T intron_variant PACA-AU 6 16135968 16135968 single base substitution G A intron_variant PACA-AU 6 16136485 16136485 single base substitution C T intron_variant PACA-AU 6 16142572 16142572 single base substitution A G intron_variant PACA-AU 6 16143035 16143035 single base substitution C G intron_variant PACA-AU 6 16143942 16143942 single base substitution T C synonymous_variant P225P 675T>C PACA-AU 6 16143942 16143942 single base substitution T C synonymous_variant P44P 132T>C PACA-CA 6 16124449 16124449 single base substitution G C upstream_gene_variant PACA-CA 6 16124973 16124973 single base substitution T A upstream_gene_variant PACA-CA 6 16125844 16125844 single base substitution G A upstream_gene_variant PACA-CA 6 16128761 16128761 single base substitution G A upstream_gene_variant PACA-CA 6 16135494 16135494 single base substitution C T intron_variant PACA-CA 6 16145436 16145436 single base substitution G A missense_variant R198H 593G>A PACA-CA 6 16145436 16145436 single base substitution G A missense_variant R379H 1136G>A PACA-CA 6 16146631 16146631 single base substitution A G intron_variant PACA-CA 6 16147800 16147800 single base substitution C T 3_prime_UTR_variant PACA-CA 6 16147800 16147800 single base substitution C T downstream_gene_variant PBCA-DE 6 16132065 16132065 deletion of <=200bp A - intron_variant PBCA-DE 6 16143693 16143693 single base substitution G T intron_variant PBCA-DE 6 16144331 16144331 single base substitution C T intron_variant PBCA-DE 6 16149157 16149157 single base substitution A G downstream_gene_variant PRAD-UK 6 16128093 16128093 single base substitution G A upstream_gene_variant PRAD-UK 6 16146973 16146973 single base substitution T C synonymous_variant T262T 786T>C PRAD-UK 6 16146973 16146973 single base substitution T C synonymous_variant T443T 1329T>C PRAD-US 6 16143929 16143929 single base substitution G T splice_acceptor_variant PRAD-US 6 16145318 16145318 single base substitution T C missense_variant S159P 475T>C PRAD-US 6 16145318 16145318 single base substitution T C missense_variant S340P 1018T>C PRAD-US 6 16146916 16146916 single base substitution T A synonymous_variant R243R 729T>A PRAD-US 6 16146916 16146916 single base substitution T A synonymous_variant R424R 1272T>A RECA-EU 6 16132642 16132642 single base substitution A C intron_variant RECA-EU 6 16134769 16134769 single base substitution C G intron_variant RECA-EU 6 16141436 16141436 single base substitution A G intron_variant SKCA-BR 6 16124694 16124694 single base substitution T G upstream_gene_variant SKCA-BR 6 16127021 16127021 single base substitution C T upstream_gene_variant SKCA-BR 6 16128554 16128554 single base substitution T C upstream_gene_variant SKCA-BR 6 16128558 16128558 single base substitution T C upstream_gene_variant SKCA-BR 6 16129219 16129219 single base substitution G A upstream_gene_variant SKCA-BR 6 16129220 16129220 single base substitution G A upstream_gene_variant SKCA-BR 6 16129229 16129229 single base substitution G A upstream_gene_variant SKCA-BR 6 16129240 16129240 single base substitution G A upstream_gene_variant SKCA-BR 6 16131156 16131156 single base substitution T C intron_variant SKCA-BR 6 16131266 16131266 insertion of <=200bp - AAAAAAAAG intron_variant SKCA-BR 6 16133989 16133989 single base substitution C T intron_variant SKCA-BR 6 16133990 16133990 single base substitution C T intron_variant SKCA-BR 6 16135979 16135979 insertion of <=200bp - CATATATATATATAT intron_variant SKCA-BR 6 16135979 16135979 insertion of <=200bp - CATATATAT intron_variant SKCA-BR 6 16137487 16137487 single base substitution T C intron_variant SKCA-BR 6 16144268 16144269 deletion of <=200bp GT - intron_variant SKCA-BR 6 16146009 16146009 single base substitution C T intron_variant SKCA-BR 6 16149181 16149181 single base substitution T G downstream_gene_variant SKCM-US 6 16141939 16141939 single base substitution C T 5_prime_UTR_variant SKCM-US 6 16141939 16141939 single base substitution C T missense_variant A121V 362C>T SKCM-US 6 16143273 16143273 single base substitution T C 5_prime_UTR_premature_start_codon_gain_variant SKCM-US 6 16143273 16143273 single base substitution T C synonymous_variant L163L 487T>C SKCM-US 6 16145341 16145341 single base substitution A T synonymous_variant S166S 498A>T SKCM-US 6 16145341 16145341 single base substitution A T synonymous_variant S347S 1041A>T SKCM-US 6 16145501 16145501 single base substitution C T missense_variant P220S 658C>T SKCM-US 6 16145501 16145501 single base substitution C T missense_variant P401S 1201C>T STAD-US 6 16141988 16141988 single base substitution G T 5_prime_UTR_variant STAD-US 6 16141988 16141988 single base substitution G T missense_variant K137N 411G>T STAD-US 6 16143326 16143326 single base substitution G A 5_prime_UTR_variant STAD-US 6 16143326 16143326 single base substitution G A synonymous_variant S180S 540G>A STAD-US 6 16143371 16143371 single base substitution C T synonymous_variant S14S 42C>T STAD-US 6 16143371 16143371 single base substitution C T synonymous_variant S195S 585C>T STAD-US 6 16143397 16143397 single base substitution T C missense_variant V204A 611T>C STAD-US 6 16143397 16143397 single base substitution T C missense_variant V23A 68T>C STAD-US 6 16143955 16143955 single base substitution G A missense_variant A230T 688G>A STAD-US 6 16143955 16143955 single base substitution G A missense_variant A49T 145G>A STAD-US 6 16145267 16145267 single base substitution T C missense_variant Y142H 424T>C STAD-US 6 16145267 16145267 single base substitution T C missense_variant Y323H 967T>C STAD-US 6 16145537 16145537 single base substitution G A missense_variant A232T 694G>A STAD-US 6 16145537 16145537 single base substitution G A missense_variant A413T 1237G>A THCA-SA 6 16145325 16145325 single base substitution A G missense_variant N161S 482A>G THCA-SA 6 16145325 16145325 single base substitution A G missense_variant N342S 1025A>G THCA-SA 6 16147301 16147301 single base substitution G A 3_prime_UTR_variant THCA-SA 6 16147301 16147301 single base substitution G A downstream_gene_variant UCEC-US 6 16142016 16142016 single base substitution G C 5_prime_UTR_variant UCEC-US 6 16142016 16142016 single base substitution G C missense_variant E147Q 439G>C UCEC-US 6 16145248 16145248 single base substitution A G synonymous_variant K135K 405A>G UCEC-US 6 16145248 16145248 single base substitution A G synonymous_variant K316K 948A>G

Mutation - COSMIC Sample Name Mutation ID Mutation CDS Mutation AA Mutation Description Mutation Genome Position Mutation Strand 587376 COSM1216273 c.157A>C p.S53R Substitution - Missense 6:16130626-16130626 + TCGA-BC-A10W-01 COSM3024073 c.868C>A p.R290S Substitution - Missense 6:16144937-16144937 + CHC892T COSM4958800 c.866G>A p.S289N Substitution - Missense 6:16144935-16144935 + PT42 COSM5925296 c.758T>C p.F253S Substitution - Missense 6:16143794-16143794 + TCGA-66-2773-01 COSM741262 c.1163T>C p.M388T Substitution - Missense 6:16145232-16145232 + TCGA-BR-4184-01 COSM3860191 c.688G>A p.A230T Substitution - Missense 6:16143724-16143724 + S00833 COSM313045 c.852G>T p.V284V Substitution - coding silent 6:16144921-16144921 + TCGA-EJ-5530-01 COSM1131984 c.171C>A p.N57K Substitution - Missense 6:16130640-16130640 + TCGA-HE-A5NH-01 COSM3994712 c.544A>G p.M182V Substitution - Missense 6:16143099-16143099 + SNUH_G76_S1 COSM4419966 c.985G>T p.A329S Substitution - Missense 6:16145054-16145054 + TCGA-76-6282-01 COSM3410756 c.108C>G p.I36M Substitution - Missense 6:16130577-16130577 + TCGA-36-2534-01 COSM1329218 c.1172G>T p.C391F Substitution - Missense 6:16145241-16145241 + 113368 COSM325896 c.310C>T p.L104F Substitution - Missense 6:16141656-16141656 + KPOPBR-46-T COSM5964699 c.57G>A p.A19A Substitution - coding silent 6:16129379-16129379 + TCGA-CC-A7IG-01 COSM4942957 c.1005T>A p.V335V Substitution - coding silent 6:16145074-16145074 + TCGA-CG-5721-01 COSM3860187 c.411G>T p.K137N Substitution - Missense 6:16141757-16141757 + S10_pre COSM5489270 c.787G>A p.G263R Substitution - Missense 6:16143823-16143823 + PD3945a COSM219257 c.473C>G p.A158G Substitution - Missense 6:16143028-16143028 + TCGA-06-0743-01 COSM3410759 c.516A>C p.E172D Substitution - Missense 6:16143071-16143071 + TCGA-D1-A16N-01 COSM1075714 c.1290C>G p.H430Q Substitution - Missense 6:16146703-16146703 + S00833 COSM313045 c.852G>T p.V284V Substitution - coding silent 6:16144921-16144921 + TCGA-BR-4361-01 COSM3860193 c.1237G>A p.A413T Substitution - Missense 6:16145306-16145306 + Pa16C COSM84962 c.675T>C p.P225P Substitution - coding silent 6:16143711-16143711 + PCSI_0083_Pa_P COSM3381512 c.1136G>A p.R379H Substitution - Missense 6:16145205-16145205 + TCGA-AP-A0LF-01 COSM1075712 c.439G>C p.E147Q Substitution - Missense 6:16141785-16141785 + TCGA-BR-4361-01 COSM3860190 c.611T>C p.V204A Substitution - Missense 6:16143166-16143166 + TCGA-61-2094-01 COSM116243 c.490G>A p.E164K Substitution - Missense 6:16143045-16143045 + SM-4B296 COSM4411553 c.662+10G>C p.? Unknown 6:16143227-16143227 + HT115 COSM3024059 c.285C>A p.I95I Substitution - coding silent 6:16141631-16141631 + AOCS-092-3-3 COSM4149253 c.302A>T p.K101M Substitution - Missense 6:16141648-16141648 + T578 COSM1442091 c.160T>G p.L54V Substitution - Missense 6:16130629-16130629 + TCGA-D8-A1XS-01 COSM1487436 c.1078T>A p.C360S Substitution - Missense 6:16145147-16145147 + CSCC-44-T COSM4508413 c.774C>T p.T258T Substitution - coding silent 6:16143810-16143810 + SS6003111 COSM3982137 c.828-8C>T p.? Unknown 6:16144889-16144889 + 66 COSM4971403 c.578G>A p.R193Q Substitution - Missense 6:16143133-16143133 + AOCS-078-1-9 COSM4149254 c.921T>G p.L307L Substitution - coding silent 6:16144990-16144990 + TCGA-AA-3672-01 COSM266983 c.819A>G p.A273A Substitution - coding silent 6:16143855-16143855 + CSCC-16-T COSM4455899 c.94A>G p.R32G Substitution - Missense 6:16130563-16130563 + ME012T COSM224679 c.765G>T p.M255I Substitution - Missense 6:16143801-16143801 + PD3945a COSM219257 c.473C>G p.A158G Substitution - Missense 6:16143028-16143028 + LUAD-RT-S01831 COSM384481 c.152G>T p.G51V Substitution - Missense 6:16130621-16130621 + TCGA-FS-A4F5-06 COSM3622620 c.487T>C p.L163L Substitution - coding silent 6:16143042-16143042 + TCGA-D5-6928-01 COSM1442093 c.1184T>A p.I395N Substitution - Missense 6:16145253-16145253 + TCGA-22-1012-01 COSM741263 c.786C>T p.S262S Substitution - coding silent 6:16143822-16143822 + 2293782 COSM4609217 c.1265G>T p.R422M Substitution - Missense 6:16146678-16146678 + 220 COSM4425257 c.1326G>C p.L442L Substitution - coding silent 6:16146739-16146739 + TCGA-B5-A0JY-01 COSM1075713 c.948A>G p.K316K Substitution - coding silent 6:16145017-16145017 + TCGA-EE-A20H-06 COSM3622622 c.1201C>T p.P401S Substitution - Missense 6:16145270-16145270 + TCGA-76-6282-01 COSM3410757 c.186C>T p.I62I Substitution - coding silent 6:16130655-16130655 + SW48 COSM3024073 c.868C>A p.R290S Substitution - Missense 6:16144937-16144937 + PCSI_0083_Pa_X COSM3381512 c.1136G>A p.R379H Substitution - Missense 6:16145205-16145205 + 2246942 COSM4413490 c.868C>T p.R290C Substitution - Missense 6:16144937-16144937 + HCC2998 COSM4631817 c.17C>T p.T6M Substitution - Missense 6:16129339-16129339 + TCGA-28-5216-01 COSM3410758 c.304G>C p.E102Q Substitution - Missense 6:16141650-16141650 + 19M COSM5579029 c.594G>A p.Q198Q Substitution - coding silent 6:16143149-16143149 + TCGA-BR-4201-01 COSM3860189 c.585C>T p.S195S Substitution - coding silent 6:16143140-16143140 + PCSI_0083_Pa_P_526 COSM3381512 c.1136G>A p.R379H Substitution - Missense 6:16145205-16145205 + Sample_1 COSM4999246 c.1025A>G p.N342S Substitution - Missense 6:16145094-16145094 + PD5942a COSM5785289 c.101T>A p.L34Q Substitution - Missense 6:16130570-16130570 + ESO-0280 COSM1258491 c.577C>T p.R193W Substitution - Missense 6:16143132-16143132 + SJHGG073_A COSM4971403 c.578G>A p.R193Q Substitution - Missense 6:16143133-16143133 + RKO COSM3024064 c.568C>T p.H190Y Substitution - Missense 6:16143123-16143123 + TCGA-GM-A3NW-01 COSM3024064 c.568C>T p.H190Y Substitution - Missense 6:16143123-16143123 + 8062307 COSM84962 c.675T>C p.P225P Substitution - coding silent 6:16143711-16143711 + MD-343 COSM302712 c.800C>T p.A267V Substitution - Missense 6:16143836-16143836 + T3174 COSM3024075 c.1003G>A p.V335I Substitution - Missense 6:16145072-16145072 + 345973 COSM3024067 c.748G>A p.V250M Substitution - Missense 6:16143784-16143784 + MD-144 COSM302711 c.1136G>C p.R379P Substitution - Missense 6:16145205-16145205 + TCGA-CH-5767-01 COSM1131983 c.1018T>C p.S340P Substitution - Missense 6:16145087-16145087 + PT25 COSM5904837 c.796C>T p.R266* Substitution - Nonsense 6:16143832-16143832 + TCGA-AA-3492-01 COSM1442092 c.1173C>T p.C391C Substitution - coding silent 6:16145242-16145242 + LUAD-YINHD COSM351351 c.283A>T p.I95F Substitution - Missense 6:16141629-16141629 + TCGA-KK-A59V-01 COSM4878589 c.663-1G>T p.? Unknown 6:16143698-16143698 + YUCROFT COSM1696940 c.797G>A p.R266Q Substitution - Missense 6:16143833-16143833 + TCGA-39-5022-01 COSM741265 c.118G>A p.D40N Substitution - Missense 6:16130587-16130587 + CHC892T COSM4958800 c.866G>A p.S289N Substitution - Missense 6:16144935-16144935 + TCGA-BR-8372-01 COSM3860192 c.967T>C p.Y323H Substitution - Missense 6:16145036-16145036 + LP6007394-DNA_A01 COSM5952616 c.1297delC p.L433fs*10 Deletion - Frameshift 6:16146710-16146710 + 0009_CRUK_PC_0009_T1_DNA COSM5423425 c.1329T>C p.T443T Substitution - coding silent 6:16146742-16146742 + TCGA-EE-A29S-06 COSM3622621 c.1041A>T p.S347S Substitution - coding silent 6:16145110-16145110 + S10_post COSM5489270 c.787G>A p.G263R Substitution - Missense 6:16143823-16143823 + TCGA-CA-6717-01 COSM1442091 c.160T>G p.L54V Substitution - Missense 6:16130629-16130629 + SC_9008 COSM5550968 c.1104C>T p.C368C Substitution - coding silent 6:16145173-16145173 + SCC-25 COSM3024053 c.111delA p.I37fs*20 Deletion - Frameshift 6:16130580-16130580 + 2218463 COSM4421286 c.1304C>T p.T435M Substitution - Missense 6:16146717-16146717 + TCGA-CD-8535-01 COSM3860188 c.540G>A p.S180S Substitution - coding silent 6:16143095-16143095 + J87_T COSM3948741 c.154G>T p.E52* Substitution - Nonsense 6:16130623-16130623 + C008 COSM5523209 c.572C>T p.S191F Substitution - Missense 6:16143127-16143127 + PDA_024 COSM4999246 c.1025A>G p.N342S Substitution - Missense 6:16145094-16145094 + TCGA-CW-5581-01 COSM483650 c.1316T>C p.L439P Substitution - Missense 6:16146729-16146729 + TCGA-FW-A3R5-06 COSM3921048 c.362C>T p.A121V Substitution - Missense 6:16141708-16141708 + sysucc-1397T COSM3860189 c.585C>T p.S195S Substitution - coding silent 6:16143140-16143140 + TCGA-EJ-A46G-01 COSM3783956 c.1272T>A p.R424R Substitution - coding silent 6:16146685-16146685 + HN_01000 COSM121263 c.705G>A p.K235K Substitution - coding silent 6:16143741-16143741 + ESCC_63 COSM5633383 c.1276G>C p.E426Q Substitution - Missense 6:16146689-16146689 + LC_C6 COSM1186962 c.847G>T p.A283S Substitution - Missense 6:16144916-16144916 + TCGA-AA-3715-01 COSM269667 c.1233C>T p.C411C Substitution - coding silent 6:16145302-16145302 + ACINAR28 COSM1733521 c.739A>G p.N247D Substitution - Missense 6:16143775-16143775 + H23 COSM1196359 c.976G>T p.A326S Substitution - Missense 6:16145045-16145045 +

Mutation - CGAP UNIGENE CYTOBAND OMIM SNP Hs.484738 6p23-p22.3 610082

Mutation - IntOGen Mutated from(ref) Mutated to(alt) Consequence Type AA Mutation CDS Mutation Chr Pos Cancer A C Missense p.E172D c.516A>C 6 16143302 GBM A T Synonymous p.S347S c.1041A>T 6 16145341 CM C A Missense p.Q64K c.190C>A 6 16130890 LUAD CC TT Missense p.P401L c.1202_1203delinsTT 6 16145502 CM C G Missense p.I36M c.108C>G 6 16130808 GBM C G Nonsense p.S354* c.1061C>G 6 16145361 LUAD C T IntronicSNV . c.827+72C>T 6 16144166 PIA C T Missense p.L104F c.310C>T 6 16141887 SCLC C T Missense p.P401S c.1201C>T 6 16145501 CM C T Nonsense p.Q198* c.592C>T 6 16143378 LUAD C T Synonymous p.H272H c.816C>T 6 16144083 CM C T Synonymous p.I62I c.186C>T 6 16130886 GBM C T Synonymous p.S195S c.585C>T 6 16143371 STAD C T Synonymous p.S262S c.786C>T 6 16144053 LUSC G A Missense p.D40N c.118G>A 6 16130818 LUSC G A Missense p.E164K c.490G>A 6 16143276 OV G A Missense p.G23D c.68G>A 6 16129621 STAD G A Synonymous p.K235K c.705G>A 6 16143972 HNSC G C Missense p.E102Q c.304G>C 6 16141881 GBM G C Missense p.E147Q c.439G>C 6 16142016 UCEC G T Missense p.K79N c.237G>T 6 16130937 LUAD G T Missense p.M255I c.765G>T 6 16144032 CM G T Missense p.M66I c.198G>T 6 16130898 LUAD G T Nonsense p.E392* c.1174G>T 6 16145474 STAD G T Synonymous p.L200L c.600G>T 6 16143386 HNSC G T Synonymous p.V117V c.351G>T 6 16141928 HNSC G T Synonymous p.V284V c.852G>T 6 16145152 SCLC T A Missense p.C360S c.1078T>A 6 16145378 BRCA T A Synonymous p.R424R c.1272T>A 6 16146916 PRAD T C Missense p.L439P c.1316T>C 6 16146960 RCCC T C Missense p.M388T c.1163T>C 6 16145463 LUSC T C Missense p.S340P c.1018T>C 6 16145318 PRAD T C Synonymous p.P225P c.675T>C 6 16143942 PAAD T - IntronicDeletion . c.662+24delT 6 16143466 STAD