PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus SCN2B UBE3C 26186194 biogrid exp P G P GP G GP GP G P P P P GP P G P P P GP GP P P P UBE3C PANK4 22863883 biogrid exp G GP G G GP GP G GP GP G GP GP GP G G GP GP G GP G GP GP GP GP GP G GP GP G KDM1A UBE3C 22939629 biogrid exp G GP G G GP GP G GP GP G GP GP GP G G GP GP G GP G GP G GP GP GP GP GP GP G UBE3C RBM15 22939629 biogrid exp G GP G G GP GP G GP GP G GP GP GP G G GP GP G GP G GP GP GP GP GP GP GP GP G RAD21 UBE3C 22145905 biogrid exp G GP G G GP GP G GP GP G GP GP GP G G GP GP G GP G GP GP GP GP GP GP GP GP G PHKA2 UBE3C 22939629 biogrid exp G GP G G GP GP G GP GP G GP GP GP G G GP GP G GP G GP GP GP GP GP GP GP GP G NTRK1 UBE3C 25921289 biogrid exp P P G P P P P P P P P P P P P P P PSMA2 UBE3C 19193609 biogrid exp G GP G G GP GP G GP GP G GP GP GP G G GP GP G GP G GP GP GP G GP GP GP GP G UBE3C CPEB4 22939629 biogrid exp G GP G G GP GP G GP GP G GP GP GP G G GP GP G GP G GP GP GP GP GP G GP GP G UBE3C THOC2 22939629 biogrid exp G GP G G GP GP G GP GP G GP GP GP G G GP GP G GP G GP GP GP GP GP GP GP GP G GOLGA2 UBE3C 25416956,21516116 biogrid,intact exp G GP G G GP GP G GP GP G GP GP GP G G GP GP G GP G GP GP GP G GP GP GP GP G MTA2 UBE3C 21988832 biogrid,intact exp P P P P P P P P GP P P P P P P P P P P EFNB2 UBE3C 26186194 biogrid exp G GP G G GP GP G GP GP G GP GP GP G G GP GP G GP G GP GP GP GP GP GP GP GP G EEF2K UBE3C 22863883 biogrid exp G G G G GP G G G GP G G G GP G G G G G GP G GP GP GP G G G GP G G UBE3C VSIG4 26186194 biogrid exp G G G G G GP G G G G G G GP G G G GP G G G GP G G G G G GP GP G PSMC5 UBE3C 12692129,11278995 biogrid exp G GP G G GP GP G GP GP G GP GP GP G G GP GP G GP G GP GP GP GP GP GP GP GP G UBE3C ECT2 22990118 biogrid exp G G G G G G G G G G ANXA7 UBE3C 26067607 biogrid exp G GP G G GP GP G GP GP G GP GP GP G G G GP G GP G GP GP GP GP G GP GP GP G SHFM1 UBE3C 24811749 biogrid,intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PSMD6 UBE3C 12692129 biogrid exp G GP G G GP GP G GP GP G GP GP GP G G GP GP G GP G GP GP GP GP GP GP GP GP G UBE3C TLK1 21988832 biogrid,intact exp G GP G G G GP G GP GP G GP GP GP G G GP GP G GP G GP GP GP GP GP GP GP GP G PSMD2 UBE3C 12692129,11278995,24158444 hprd,biogrid,bci exp G GP G G GP GP G GP GP G GP GP GP G G GP GP G GP G GP GP GP GP GP GP GP GP G PSMD14 UBE3C 24743594,17323924 biogrid exp G GP G G GP GP G GP GP G GP GP GP G G GP GP G GP G GP G G GP GP G GP GP G UBE3C LRRK2 24725412 intact exp G G G G G GP G GP G G GP GP GP G G G GP G GP G G G GP G G GP P G UBE3C ELAVL1 19322201 biogrid exp G GP G G GP GP G GP GP G GP GP GP G G GP GP G GP G GP GP GP GP GP G GP GP G UBE3C HUWE1 bci exp G GP G G GP GP G GP GP G GP GP GP G G GP GP G GP G GP GP GP GP GP GP GP GP G APP UBE3C 21832049 biogrid exp G GP G G GP GP G G GP G G G G G G GP GP G GP G GP GP G G GP G G GP G UBE3C UBE3C 23606334,12692129,9575161,11278995,22496338 hprd,biogrid,intact exp G GP G G GP GP G GP GP G GP GP GP G G GP GP G GP G GP GP GP GP GP GP GP GP G UTRN UBE3C 22939629 biogrid exp G GP G G GP GP G GP GP G GP G GP G G GP GP G GP G GP GP GP GP GP GP GP GP G UBC UBE3C 14517261,16601690,25752577 biogrid exp G GP G G GP GP G GP GP G GP GP GP G G GP GP G GP G GP GP GP GP GP GP GP GP G UBE3C THOC7 22939629 biogrid exp G GP G G GP GP G G GP G GP G GP G G GP GP G GP G GP GP GP G GP GP GP GP G UBE3C WDR92 22863883 biogrid exp P P P P P P P P P P P P P P P P P P P UBE3C WDR74 22939629 biogrid exp G G G G G G G GP G G G G G G G G G G G G G G G GP G G G G G MYC UBE3C 17314511 biogrid,i2d,intact exp G GP G GP P G GP GP GP GP GP G G GP P G GP GP GP GP GP GP GP GP GP G UBE3C USP13 22939629 biogrid exp G GP G G GP GP G GP GP G GP GP GP G G GP GP G GP G GP GP GP GP GP G GP GP G PTP4A3 UBE3C 17353931 intact exp G GP G G G G G G G G G G G G G GP G G G G G G G G GP G GP G G UBE2D2 UBE3C 14517261, 21836163, 16082366 biogrid exp, pred G G G G GP GP G G GP G GP GP GP G G G GP G GP G GP GP G GP G GP GP GP G CAND2 UBE3C 12692129, 21836163 hprd,biogrid exp, pred G GP G G GP GP G GP GP G GP G GP G G GP GP G GP G P G G GP GP G GP GP G UBE2D1 UBE3C 12692129,9575161,11278995,16601690,22939629, 16082366 biogrid exp, pred G G G G GP GP G G GP G GP GP GP G G G GP G GP G GP GP G GP G GP GP GP G UBE2L3 UBE3C 9575161,25752577, 16082366 biogrid exp, pred G G G G G GP G GP GP G GP G G G G GP GP G GP G G G GP GP GP G GP GP G UBE3C UBE2V2 16082366 bci exp, pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G YWHAE UBE3C ortho G GP G G GP GP G GP GP G GP GP GP G G GP GP G GP G GP GP GP GP GP GP GP GP G EED UBE3C ortho G GP G G G GP G GP GP G GP GP GP G G GP GP G GP G GP G GP GP GP GP GP GP G UBE2K UBE3C ortho G GP G G GP GP G GP GP G GP GP GP G G GP GP G GP G GP GP GP GP GP GP GP GP G YWHAH UBE3C ortho G GP G G GP GP G GP GP G GP GP GP G G GP GP G GP G GP GP GP GP GP GP GP GP G UBE3C RNF123 21836163 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G UBE3C RNF144B 21836163 pred G GP G G G GP G GP GP G GP GP GP G G GP GP G GP G GP G G G GP G G GP G UBE3C FBXW7 21836163 pred G GP G G GP GP G GP GP G GP GP GP G G GP GP G GP G P GP GP GP GP GP GP GP CUL4B UBE3C 21836163 pred G GP G G GP GP G GP GP G GP GP G G G GP GP G GP G GP GP GP GP GP GP GP GP G UBE3C UBE2R2 16082366 pred G G G G GP G G G G G G G G G G G G G G G G G G G G GP GP G G UBE2E1 UBE3C 16082366 pred G GP G G G GP G G GP G GP G G G G GP GP G G G GP G G GP GP G GP GP G UBE2A UBE3C 16082366 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G UBE3C 16082366 pred RPN1 UBE3C 21836163 pred G GP G G GP GP G GP GP G G GP GP G G GP GP G GP G GP GP GP GP GP GP GP GP G UBE3C AKTIP 16082366 pred G GP G G GP GP G GP GP G GP GP GP G G GP GP G GP G GP GP GP GP GP GP GP GP G UBE2B UBE3C 23023127, 16082366 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G UBE2L6 UBE3C 16082366 pred G GP G G GP GP G G GP G GP GP GP G G GP GP G GP G GP GP GP G GP GP GP GP G UBE2C UBE3C 16082366 pred G GP G G GP GP G GP GP G GP GP GP G G GP GP G GP G GP GP GP GP GP GP GP GP G PSMD9 UBE3C 21836163 pred G GP G G GP GP G GP GP G GP GP GP G G GP GP G GP G GP GP GP GP GP GP GP GP G UBE3C MYLIP 21836163 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G UBE3C RCHY1 21836163 pred G GP G G G GP G GP GP G GP G GP G G GP GP G GP G G G GP G GP G GP G G CTBP1 UBE3C 21836163 pred G GP G G GP GP G GP GP G GP GP GP G G GP GP G GP G GP GP GP GP GP GP GP GP G UBE3C UFC1 16082366 pred G GP G G G GP G GP GP G GP G GP G G GP GP G GP G GP GP GP GP GP G GP GP G UBE3C MIB1 21836163 pred G GP G G GP GP G G GP G GP GP G G G GP GP G GP G GP GP GP G GP G GP GP G UBE3C GCM1 21836163 pred P P GP P P UBE3C TSG101 16082366 pred G GP G G GP GP G GP GP G GP GP GP G G GP GP G GP G GP GP GP GP GP GP GP GP G UBE3C LRSAM1 21836163 pred GP G P GP G P GP G GP GP P G P GP G GP G P GP P P P GP P P G UBE3C LNX1 21836163 pred G G G GP G GP GP G GP GP GP G G GP GP G GP G GP GP GP G GP P GP GP UBE3C BIRC6 16082366 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G UBE3C PJA1 21836163 pred G GP G G GP GP G GP GP G GP G GP G G GP GP G GP G GP GP GP GP GP GP GP GP G UBE3C RNF25 21836163 pred P G P P P P P P P P P P P P GP P P CUL1 UBE3C 21836163 pred G G G G G GP G GP GP G GP GP GP G G GP GP G GP G GP GP GP GP GP GP GP GP G UBE3C UBQLN2 21836163 pred G GP G G GP GP G GP GP G GP GP GP G G GP GP G GP G GP GP GP GP GP GP GP GP G UBE2H UBE3C 16082366 pred G GP G G GP GP G GP G G GP GP GP G G GP GP G GP G GP GP GP GP GP GP GP GP G RBX1 UBE3C 21836163 pred G G G G G GP G GP G G G G GP G G G GP G GP G GP GP G G G G G GP G UBE3C TRIM11 21836163 pred G GP G G GP GP G GP GP G GP GP GP G G GP GP G GP G GP GP GP P GP GP GP GP G UBE2N UBE3C 16082366 pred G GP G G GP GP G GP GP G GP GP GP G G GP GP G GP G GP GP GP GP GP GP GP GP G UBE3C UBE2Z 16082366 pred G GP G G GP GP G G GP G GP GP GP G G GP GP G GP G GP GP GP GP GP GP GP GP G UBE3C UBE2U 16082366 pred P P P P P P P P P P P P P P P P P GP UBE3C FBXW11 21836163 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G UBE2M UBE3C 16082366 pred G GP G G GP GP G GP GP G GP G GP G G GP GP G GP G GP G GP GP GP GP GP GP G UBE3C UBE2E3 16082366 pred G GP G G G GP G G GP G GP G G G G GP GP G G G GP G G GP GP G GP GP G CDC34 UBE3C 16082366 pred G GP G G GP GP G GP GP G GP GP GP G G GP GP G GP G GP GP GP GP GP GP GP GP G UBE3C FBXO18 21836163 pred G GP G G GP GP G GP GP G GP GP GP G G GP GP G GP G GP GP GP GP GP GP GP GP G UBE3C UBE2T 16082366 pred G G G GP G GP P P GP GP P GP P G GP P GP G UBE2D3 UBE3C 23023127 pred G G G G GP GP G G GP G GP GP GP G G G GP G GP G GP GP G GP G GP GP GP G UBE3C NEDD8 21836163 pred G GP G G GP GP G GP GP G GP GP GP G G GP GP G GP G GP GP GP GP GP GP GP GP G UBE2I UBE3C 16082366 pred G GP G G GP GP G GP GP G GP G GP G G GP GP G GP G GP GP GP G GP GP GP GP G DLGAP1 UBE3C 21836163 pred GP G P GP P P G P P P P GP P G P P GP P P GP UBE3C BRAP 21836163 pred P G GP P GP P P P P G GP P P G GP P GP GP GP P P GP UBE3C RNF20 21836163 pred G GP G G GP GP G GP GP G GP GP GP G G GP GP G GP G GP GP GP GP GP GP GP GP G UBE3C UBE2S 16082366 pred G G G G G G G G GP G G G G G G G G G G G G G G G GP G UBE3C UBE2F 16082366 pred G GP G G GP GP G GP GP G GP GP GP G G GP GP G GP G GP GP GP GP GP GP GP GP G UBE3C SENP8 21836163 pred P G P GP G GP P G GP P P P P G P G P GP P GP GP P P GP UBE3C MBD1 21836163 pred G GP G G GP GP G GP GP G GP GP GP G G GP GP G GP G GP GP GP GP GP GP GP GP G UBE3C UBE2D4 16082366 pred G G G G GP GP G G GP G GP GP GP G G G GP G GP G GP GP G GP G GP GP GP G UBE2G1 UBE3C 16082366 pred G GP G G GP GP G GP GP G GP GP GP G G GP GP G GP G GP GP GP GP GP GP GP GP G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q15386 Q15386 enzymatic study 9575161 direct interaction X 2 Q15386 Q15386 enzymatic study 22496338 direct interaction X 2 Q15386 Q96T37 biochemical 22939629 colocalization X 2 Q15386 O60341 biochemical 22939629 colocalization X 2 Q15386 P46019 biochemical 22939629 colocalization X 2 Q15386 Q9H8V3-4 affinity chromatography technology 22990118 physical association X 2 Q15386 Q96MX6 biochemical 22863883 colocalization X 2 Q15386 P62195 pull down 11278995 direct interaction X 2 Q15386 Q08379 two hybrid 25416956 direct interaction X 2 Q15386 Q15386 enzymatic study 11278995 direct interaction X 2 Q15386 P62837 pull down 14517261 direct interaction X 2 Q15386 P62195 affinity chromatography technology 12692129 physical association X 2 Q15386 O75155-2 enzymatic study 12692129 direct interaction X 2 A0A024R534 Q15386 two hybrid 21988832 direct interaction X 2 Q15386 biochemical 22863883 colocalization X 2 A0A024R332 Q15386 biochemical 22939629 colocalization X 2 A0A024R1A4 Q15386 pull down 9575161 direct interaction X 2 Q6RFH5 Q15386 biochemical 22939629 colocalization X 2 P01106 Q15386 affinity chromatography technology 17314511 physical association X 2 Q17RY0 Q15386 biochemical 22939629 colocalization X 2 P60896 Q15386 affinity chromatography technology 24811749 physical association X 2 P60896 Q15386 affinity chromatography technology 24811749 physical association X 2 A0A024R9J0 Q15386 affinity chromatography technology 22145905 physical association X 2 Q15386 P05067-7 pull down 21832049 direct interaction X 2 Q15386 Q92995 biochemical 22939629 colocalization X 2 Q15386 P46939 biochemical 22939629 colocalization X 2 Q15386 Q13200 affinity chromatography technology 24158444 physical association X 2 Q15386 O00487 affinity chromatography technology 17323924 physical association X 2 Q15386 Q13200 pull down 11278995 direct interaction X 2 Q15386 O00487 affinity chromatography technology 24743594 physical association X 2 Q15386 O00487 affinity chromatography technology 24743594 physical association X 2 Q15386 Q13200 pull down 12692129 direct interaction X 2 A0A087WW00 Q15386 pull down 12692129 direct interaction X 2 A0A087WW00 Q15386 pull down 16601690 direct interaction X 2 A0A087WW00 Q15386 pull down 9575161 direct interaction X 2 A0A087WW00 Q15386 biochemical 22939629 colocalization X 2 A0A087WW00 Q15386 biochemical 11278995 association X 2 A0A087WW00 Q15386 pull down 11278995 direct interaction X 2 Q15386 biochemical 22863883 colocalization X 2 A0A024RA52 Q15386 affinity chromatography technology 19193609 physical association X 2 Q8NI27 Q15386 biochemical 22939629 colocalization X 2 Q15008 Q15386 affinity chromatography technology 12692129 physical association X 2 B3KRP1 Q15386 two hybrid 21988832 direct interaction X 2 P0CG48 Q15386 enzymatic study 16601690 direct interaction X 2 P0CG48 Q15386 affinity chromatography technology 21963094 physical association X 2 P0CG48 Q15386 affinity chromatography technology 24816145 physical association X 2 P0CG48 Q15386 affinity chromatography technology 25147182 physical association X 2 P0CG48 Q15386 enzymatic study 14517261 direct interaction X 2 P0CG48 Q15386 affinity chromatography technology 16196087 physical association X 2 P0CG48 Q15386 affinity chromatography technology 20972266 physical association X 2 P0CG48 Q15386 affinity chromatography technology 21139048 physical association X 2 P0CG48 Q15386 affinity chromatography technology 21890473 physical association X 2 P0CG48 Q15386 affinity chromatography technology 21906983 physical association X 2 Q15386 in vivo 17720710 - C 5 Q15386 in vivo 17720710 - C 5 Q15386 in vivo 17720710 - C 5 Q15386 in vivo 17720710 - C 5 Q15386 in vivo 17720710 - C 5 Q15386 Q15386 in vitro 12692129 - X 2 Q15386 O75155-2 in vitro 12692129 - X 2 Q15386 O75155-2 in vivo 12692129 - X 2 Q15386 O75155-2 in vitro 12692129 - X 2 Q15386 O75155-2 in vivo 12692129 - X 2 Q15386 Q13200 in vitro 12692129 - X 2 Q15386 Q13200 in vitro 12692129 - X 2 Q15386 anti tag coimmunoprecipitation 24811749 association C 6 Q15386 anti tag coimmunoprecipitation 24811749 association C 66 Q15386 tandem affinity purification 17314511 association C 222 Q15386 tandem affinity purification 24725412 association C 161 Q15386 Q08379 two hybrid prey pooling approach 25416956 physical association X 2 Q15386 Q08379 two hybrid array 25416956 physical association X 2 Q15386 Q08379 validated two hybrid 25416956 physical association X 2 A0A024R534 Q15386 two hybrid array 21988832 physical association X 2 O75365 Q15386 anti bait coimmunoprecipitation 17353931 physical association X 2 Q9UKI8 Q15386 two hybrid array 21988832 physical association X 2 Q15386 anti tag coimmunoprecipitation 24811749 association C 10

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B UBE2D1 UBE3C MI:0415(enzymatic study)|MI:0415(enzymatic study)|MI:0096(pull down)|MI:0401(biochemical) 12692129,16601690,22939629,9575161 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0403(colocalization) (biogrid)|(biogrid)|(biogrid)|(biogrid) BIOGRID_225959|BIOGRID_225661|BIOGRID_221441|BIOGRID_238305 prey|prey|prey|bait bait|bait|bait|prey PSMA2 UBE3C MI:0004(affinity chromatography technology) 19193609 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_200356 bait prey MTA2 UBE3C MI:0397(two hybrid array)|MI:0004(affinity chromatography technology) 21988832 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_117537|BIOGRID_287884 unspecified role|bait unspecified role|prey UBE3C PANK4 MI:0401(biochemical) 22863883 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_304765 prey bait PSMC5 UBE3C MI:0096(pull down) 12692129 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_89658 bait prey UBE3C USP13 MI:0401(biochemical) 22939629 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_241995 bait prey KDM1A UBE3C MI:0401(biochemical) 22939629 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_239541 bait prey UBE3C ELAVL1 MI:0096(pull down) 19322201 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_187882 prey bait PSMD6 UBE3C MI:0096(pull down) 12692129 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_89659 bait prey PSMD2 UBE3C MI:0096(pull down)|MI:0004(affinity chromatography technology)|MI:0492(in vitro) 12692129,24158444 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association)|- (biogrid)|(biogrid)|MI:0468(hprd) BIOGRID_89657|BIOGRID_294206|HPRD_13906 bait|bait|- prey|prey|- UBE3C TLK1 MI:0397(two hybrid array)|MI:0004(affinity chromatography technology) 21988832 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_117538|BIOGRID_287887 unspecified role|prey unspecified role|bait MYC UBE3C MI:0004(affinity chromatography technology)|MI:0676(tandem affinity purification) 17314511 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0914(association) (biogrid)|(intact) BIOGRID_144188|UniProt_89764 bait|bait prey|prey PHKA2 UBE3C MI:0401(biochemical) 22939629 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_239782 bait prey EEF2K UBE3C MI:0401(biochemical) 22863883 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_304764 bait prey UTRN UBE3C MI:0401(biochemical) 22939629 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_242806 prey bait UBE3C WDR74 MI:0401(biochemical) 22939629 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_238783 bait prey RAD21 UBE3C MI:0018(two hybrid) 22145905 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_181977 bait prey UBE3C ECT2 MI:0004(affinity chromatography technology) 22990118 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_245911 prey bait UBE3C CPEB4 MI:0401(biochemical) 22939629 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_240411 prey bait APP UBE3C MI:0096(pull down) 21832049 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_229235 prey bait UBE3C WDR92 MI:0401(biochemical) 22863883 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_304766 prey bait CAND2 UBE3C MI:0492(in vitro)|MI:0096(pull down) 12692129 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) -|MI:0407(direct interaction) MI:0468(hprd)|(biogrid) HPRD_30358|BIOGRID_89660 -|prey -|bait UBE3C THOC7 MI:0401(biochemical) 22939629 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_237498 prey bait UBE3C RBM15 MI:0401(biochemical) 22939629 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_237175 prey bait PTP4A3 UBE3C MI:0006(anti bait coimmunoprecipitation) 17353931 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (intact) UniProt_144948 bait prey UBE2L3 UBE3C MI:0415(enzymatic study) 9575161 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_225960 prey bait UBC UBE3C MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0415(enzymatic study)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 16196087,16601690,20972266,21139048,21890473,21906983,21963094 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid) BIOGRID_164276|BIOGRID_176037|BIOGRID_178756|BIOGRID_192331|BIOGRID_264613|BIOGRID_169438|BIOGRID_142936 bait|bait|bait|prey|bait|bait|bait prey|prey|prey|bait|prey|prey|prey UBE3C THOC2 MI:0401(biochemical) 22939629 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_236715 prey bait

PPI - HINT Gene A Gene B PMID Method Quality EEF2K UBE3C 22863883 0401 HT PSMD14 UBE3C 17323924,24743594 0004,0004 LC KDM1A UBE3C 22939629 0401 HT SCN2B UBE3C 26186194 0004 HT PTP4A3 UBE3C 17353931 0006 HT PHKA2 UBE3C 22939629 0401 HT UBE2D1 UBE3C 11278995,12692129,16601690,25723849,11278995,9575161,22939629 0401,0096,0096,0096,0096,0096,0401 LC,HT EFNB2 UBE3C 26186194 0004 HT UBE2D3 UBE3C 26389696,25723849 0096,0096 LC PSMC5 UBE3C 11278995,12692129 0096,0004 LC UBE2D2 UBE3C 14517261,25723849 0096,0096 LC UBE2L3 UBE3C 25752577,25723849,9575161,26949039 0096,0096,0096,0096 LC PSMD2 UBE3C 12692129,11278995,24158444 0096,0096,0004 LC UBE3C CPEB4 22939629 0401 HT UBE3C THOC7 22939629 0401 HT UBE3C Q6LBS5 22939629 0401 HT UBE3C WDR74 22939629 0401 HT UBE3C THOC2 22939629 0401 HT UBE3C USP13 22939629 0401 HT UBE3C WDR92 22863883 0401 HT UBE3C RBM15 22939629 0401 HT UBE3C PANK4 22863883 0401 HT UBE3C VSIG4 26186194 0004 HT EEF2K UBE3C 22863883 0401 HT KDM1A UBE3C 22939629 0401 HT SCN2B UBE3C 26186194 0004 HT PTP4A3 UBE3C 17353931 0006 HT PHKA2 UBE3C 22939629 0401 HT UBE2D1 UBE3C 22939629 0401 HT EFNB2 UBE3C 26186194 0004 HT UBE3C CPEB4 22939629 0401 HT UBE3C THOC7 22939629 0401 HT UBE3C Q6LBS5 22939629 0401 HT UBE3C WDR74 22939629 0401 HT UBE3C THOC2 22939629 0401 HT UBE3C USP13 22939629 0401 HT UBE3C WDR92 22863883 0401 HT UBE3C RBM15 22939629 0401 HT UBE3C PANK4 22863883 0401 HT UBE3C VSIG4 26186194 0004 HT PSMD14 UBE3C 17323924,24743594 0004,0004 LC UBE2D1 UBE3C 11278995,12692129,16601690,25723849,11278995,9575161 0401,0096,0096,0096,0096,0096 LC UBE2D3 UBE3C 26389696,25723849 0096,0096 LC PSMC5 UBE3C 11278995,12692129 0096,0004 LC UBE2D2 UBE3C 14517261,25723849 0096,0096 LC UBE2L3 UBE3C 25752577,25723849,9575161,26949039 0096,0096,0096,0096 LC PSMD2 UBE3C 12692129,11278995,24158444 0096,0096,0004 LC EEF2K UBE3C 22863883 0401 LC KDM1A UBE3C 22939629 0401 LC CAND2 UBE3C 12692129 0415 LC MTA2 UBE3C 21988832,21988832 0397,0018 HT UBC UBE3C 14517261,25723849,16601690,25752577,26389696 0415,0415,0415,0415,0415 LC CCNB1 UBE3C 26389696,26389696 0415,0096 LC PHKA2 UBE3C 22939629 0401 LC UBE2D1 UBE3C 11278995,11278995,22939629 0401,0096,0401 LC GOLGA2 UBE3C 25416956,25416956,25416956,21516116,25416956 1112,0397,0018,0018,1356 HT UBE3C UBE3C 26949039,22496338,9575161,11278995 0415,0415,0415,0415 LC UBE3C CPEB4 22939629 0401 LC UBE3C THOC7 22939629 0401 LC UBE3C Q6LBS5 22939629 0401 LC UBE3C WDR74 22939629 0401 LC UBE3C THOC2 22939629 0401 LC UBE3C USP13 22939629 0401 LC UBE3C WDR92 22863883 0401 LC UBE3C RBM15 22939629 0401 LC UBE3C PANK4 22863883 0401 LC UBE3C TLK1 21988832,21988832 0397,0018 HT

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q15386 B4URF5 UBE3C PB1 {ECO:0000313|EMBL:ACF54606.1} 0.126 unassigned1333 Q5S007 Q15386 LRRK2 UBE3C 0.126 24725412 Q9H8V3 Q15386 ECT2 UBE3C 0.126 22990118 Q15386 O60216 UBE3C RAD21 0.126 22145905 Q15386 O60341 UBE3C KDM1A 0.081 22939629 Q8NI27 Q15386 THOC2 UBE3C 0.081 22939629 Q15386 O60939 UBE3C SCN2B 0.126 26186194 Q9NVE7 Q15386 PANK4 UBE3C 0.081 22863883 Q15386 P25787 UBE3C PSMA2 0.126 19193609 Q9Y279 Q15386 VSIG4 UBE3C 0.126 26186194 Q6I9Y2 Q15386 THOC7 UBE3C 0.081 22939629 Q15386 P03431 UBE3C PB1 0.126 unassigned1333 Q15386 P04544 UBE3C 1C 0.126 22593156 Q15386 P04629 UBE3C NTRK1 0.126 25921289 Q15386 P01106 UBE3C MYC 0.236 17314511 Q15386 Q08379 UBE3C GOLGA2 0.554 25416956,21516116 Q15386 P61077 UBE3C UBE2D3 0.523 25723849,26389696 Q15386 P51668 UBE3C UBE2D1 0.835 12692129,16601690,25723849,22939629,11278995 Q15386 P60896 UBE3C SHFM1 0.236 24811749 Q15386 O94776 UBE3C MTA2 0.286 21988832 Q15386 P68036 UBE3C UBE2L3 0.671 25752577,25723849,26949039 Q15386 Q13200 UBE3C PSMD2 0.623 12692129,24158444,11278995 Q15386 Q15386 UBE3C UBE3C 0.801 11278995,26949039,22496338,9575161 Q15386 P0CG48 UBE3C UBC 0.772 25752577,26389696,16601690,25723849 Q96CS3 Q15386 FAF2 UBE3C 0.126 26389662 Q96MX6 Q15386 WDR92 UBE3C 0.081 22863883 Q96T37 Q15386 RBM15 UBE3C 0.081 22939629 Q9UKI8 Q15386 TLK1 UBE3C 0.286 21988832 Q15386 P46019 UBE3C PHKA2 0.081 22939629 Q15386 P14635 UBE3C CCNB1 0.523 26389696 Q15386 C5E526 UBE3C PB1 {ECO:0000313|EMBL:ACQ84475.1} 0.126 unassigned1333 Q15386 Q15008 UBE3C PSMD6 0.21 12692129 Q15386 O75155 UBE3C CAND2 0.309 12692129 Q15386 O75365 UBE3C PTP4A3 0.126 17353931 Q15386 P03372 UBE3C ESR1 0.376 26389696 Q15386 P05067 UBE3C APP 0.183 21832049 Q15386 P20073 UBE3C ANXA7 0.376 26067607 Q15386 P46939 UBE3C UTRN 0.081 22939629 Q15386 P62195 UBE3C PSMC5 0.454 12692129,11278995 Q15386 P62837 UBE3C UBE2D2 0.309 25723849 Q6RFH5 Q15386 WDR74 UBE3C 0.081 22939629 Q92995 Q15386 USP13 UBE3C 0.081 22939629 Q15717 Q15386 ELAVL1 UBE3C 0.126 19322201 Q15386 O00418 UBE3C EEF2K 0.081 22863883 Q15386 P52799 UBE3C EFNB2 0.126 26186194 Q17RY0 Q15386 CPEB4 UBE3C 0.081 22939629

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 MYO1F UBE3C MI:0362 inference MI:0461 interaction database PSMD12 UBE3C MI:0362 inference MI:0461 interaction database PSMD14 UBE3C MI:0045 experimental interaction detection MI:0461 interaction database PES1 UBE3C MI:0362 inference MI:0461 interaction database NME4 UBE3C MI:0362 inference MI:0461 interaction database RAD21 UBE3C MI:0045 experimental interaction detection MI:0461 interaction database SCN2B UBE3C MI:0045 experimental interaction detection MI:0461 interaction database CAND2 UBE3C MI:0045 experimental interaction detection MI:0461 interaction database PTP4A3 UBE3C MI:0045 experimental interaction detection MI:0461 interaction database EED UBE3C MI:0362 inference MI:0461 interaction database MTA2 UBE3C MI:0045 experimental interaction detection MI:0461 interaction database ALDH1A2 UBE3C MI:0362 inference MI:0461 interaction database HSPA4L UBE3C MI:0362 inference MI:0461 interaction database ALDH1A1 UBE3C MI:0362 inference MI:0461 interaction database SOD1 UBE3C MI:0362 inference MI:0461 interaction database MYC UBE3C MI:0045 experimental interaction detection MI:0461 interaction database ESR1 UBE3C MI:0045 experimental interaction detection MI:0461 interaction database NTRK1 UBE3C MI:0045 experimental interaction detection MI:0461 interaction database APP UBE3C MI:0045 experimental interaction detection MI:0461 interaction database ALDH2 UBE3C MI:0362 inference MI:0461 interaction database SLC25A5 UBE3C MI:0362 inference MI:0461 interaction database MYL1 UBE3C MI:0362 inference MI:0461 interaction database ATP5B UBE3C MI:0362 inference MI:0461 interaction database GPI UBE3C MI:0362 inference MI:0461 interaction database BPGM UBE3C MI:0362 inference MI:0461 interaction database UBC UBE3C MI:0045 experimental interaction detection MI:0461 interaction database HSPA1A UBE3C MI:0362 inference MI:0461 interaction database HSPA1B UBE3C MI:0362 inference MI:0461 interaction database HSPD1 UBE3C MI:0362 inference MI:0461 interaction database HSPA8 UBE3C MI:0362 inference MI:0461 interaction database PSKH1 UBE3C MI:0362 inference MI:0461 interaction database SLC25A4 UBE3C MI:0362 inference MI:0461 interaction database SLC25A6 UBE3C MI:0362 inference MI:0461 interaction database CCNB1 UBE3C MI:0045 experimental interaction detection MI:0461 interaction database PGAM2 UBE3C MI:0362 inference MI:0461 interaction database ATP6V1B1 UBE3C MI:0362 inference MI:0461 interaction database NME1 UBE3C MI:0362 inference MI:0461 interaction database PPP3CB UBE3C MI:0362 inference MI:0461 interaction database HSPA6 UBE3C MI:0362 inference MI:0461 interaction database PGAM1 UBE3C MI:0362 inference MI:0461 interaction database HK1 UBE3C MI:0362 inference MI:0461 interaction database ANXA7 UBE3C MI:0045 experimental interaction detection MI:0461 interaction database ATP6V1B2 UBE3C MI:0362 inference MI:0461 interaction database UBA1 UBE3C MI:0362 inference MI:0461 interaction database NME2 UBE3C MI:0362 inference MI:0461 interaction database CFL1 UBE3C MI:0362 inference MI:0461 interaction database PSMA2 UBE3C MI:0045 experimental interaction detection MI:0461 interaction database VARS UBE3C MI:0362 inference MI:0461 interaction database CALML3 UBE3C MI:0362 inference MI:0461 interaction database PPIF UBE3C MI:0362 inference MI:0461 interaction database ALDH1B1 UBE3C MI:0362 inference MI:0461 interaction database HSPA1L UBE3C MI:0362 inference MI:0461 interaction database HSPA4 UBE3C MI:0362 inference MI:0461 interaction database GCK UBE3C MI:0362 inference MI:0461 interaction database PGM1 UBE3C MI:0362 inference MI:0461 interaction database IARS UBE3C MI:0362 inference MI:0461 interaction database NOP2 UBE3C MI:0362 inference MI:0461 interaction database ALDH1A3 UBE3C MI:0362 inference MI:0461 interaction database PPP3CC UBE3C MI:0362 inference MI:0461 interaction database PSMB2 UBE3C MI:0362 inference MI:0461 interaction database CCT8 UBE3C MI:0362 inference MI:0461 interaction database CCT4 UBE3C MI:0362 inference MI:0461 interaction database UBE2D1 UBE3C MI:0045 experimental interaction detection MI:0461 interaction database UBE2E1 UBE3C MI:0362 inference MI:0461 interaction database EFNB2 UBE3C MI:0045 experimental interaction detection MI:0461 interaction database CLTCL1 UBE3C MI:0362 inference MI:0461 interaction database USP14 UBE3C MI:0362 inference MI:0461 interaction database HSPA2 UBE3C MI:0362 inference MI:0461 interaction database PSMD4 UBE3C MI:0362 inference MI:0461 interaction database EIF6 UBE3C MI:0362 inference MI:0461 interaction database ACTB UBE3C MI:0362 inference MI:0461 interaction database SHFM1 UBE3C MI:0045 experimental interaction detection MI:0461 interaction database DSTN UBE3C MI:0362 inference MI:0461 interaction database UBE2D3 UBE3C MI:0045 experimental interaction detection MI:0461 interaction database UBE2K UBE3C MI:0362 inference MI:0461 interaction database YWHAG UBE3C MI:0362 inference MI:0461 interaction database CALM1 UBE3C MI:0362 inference MI:0461 interaction database PSMC5 UBE3C MI:0045 experimental interaction detection MI:0461 interaction database YWHAE UBE3C MI:0362 inference MI:0461 interaction database ACTA2 UBE3C MI:0362 inference MI:0461 interaction database UBE2D2 UBE3C MI:0045 experimental interaction detection MI:0461 interaction database PPIA UBE3C MI:0362 inference MI:0461 interaction database EIF5A UBE3C MI:0362 inference MI:0461 interaction database ACTG1 UBE3C MI:0362 inference MI:0461 interaction database ACTG2 UBE3C MI:0362 inference MI:0461 interaction database ACTC1 UBE3C MI:0362 inference MI:0461 interaction database UBE2L3 UBE3C MI:0045 experimental interaction detection MI:0461 interaction database EEF1A1 UBE3C MI:0362 inference MI:0461 interaction database ACTA1 UBE3C MI:0362 inference MI:0461 interaction database CLTC UBE3C MI:0362 inference MI:0461 interaction database YWHAH UBE3C MI:0362 inference MI:0461 interaction database EEF1A2 UBE3C MI:0362 inference MI:0461 interaction database PPP3CA UBE3C MI:0362 inference MI:0461 interaction database GOLGA2 UBE3C MI:0045 experimental interaction detection MI:0461 interaction database MYO1E UBE3C MI:0362 inference MI:0461 interaction database PSMD2 UBE3C MI:0045 experimental interaction detection MI:0461 interaction database NME3 UBE3C MI:0362 inference MI:0461 interaction database CAMK1 UBE3C MI:0362 inference MI:0461 interaction database BOP1 UBE3C MI:0362 inference MI:0461 interaction database PSMD6 UBE3C MI:0045 experimental interaction detection MI:0461 interaction database PGM5 UBE3C MI:0362 inference MI:0461 interaction database PPA1 UBE3C MI:0362 inference MI:0461 interaction database UBE3C ELAVL1 MI:0045 experimental interaction detection MI:0461 interaction database UBE3C CAMK4 MI:0362 inference MI:0461 interaction database UBE3C LRRK2 MI:0045 experimental interaction detection MI:0461 interaction database UBE3C EIF5AL1 MI:0362 inference MI:0461 interaction database UBE3C PNCK MI:0362 inference MI:0461 interaction database UBE3C VPS13C MI:0362 inference MI:0461 interaction database UBE3C CAMK1D MI:0362 inference MI:0461 interaction database UBE3C XRN1 MI:0362 inference MI:0461 interaction database UBE3C PGAM4 MI:0362 inference MI:0461 interaction database UBE3C CALML6 MI:0362 inference MI:0461 interaction database UBE3C HSPH1 MI:0362 inference MI:0461 interaction database UBE3C UBE2E3 MI:0362 inference MI:0461 interaction database UBE3C FAF2 MI:0045 experimental interaction detection MI:0461 interaction database UBE3C UBE2E2 MI:0362 inference MI:0461 interaction database UBE3C CAMK1G MI:0362 inference MI:0461 interaction database UBE3C VPS13A MI:0362 inference MI:0461 interaction database UBE3C PSMD1 MI:0362 inference MI:0461 interaction database UBE3C EIF5A2 MI:0362 inference MI:0461 interaction database UBE3C SLC25A31 MI:0362 inference MI:0461 interaction database UBE3C PPA2 MI:0362 inference MI:0461 interaction database UBE3C ECT2 MI:0045 experimental interaction detection MI:0461 interaction database UBE3C MYO5C MI:0362 inference MI:0461 interaction database UBE3C PAK1IP1 MI:0362 inference MI:0461 interaction database UBE3C CALML5 MI:0362 inference MI:0461 interaction database UBE3C TLK1 MI:0045 experimental interaction detection MI:0461 interaction database UBE3C MYO5B MI:0362 inference MI:0461 interaction database UBE3C PPIE MI:0362 inference MI:0461 interaction database UBE3C VSIG4 MI:0045 experimental interaction detection MI:0461 interaction database UBE3C CFL2 MI:0362 inference MI:0461 interaction database UBE3C UBE2D4 MI:0362 inference MI:0461 interaction database UBE3C MYO5A MI:0362 inference MI:0461 interaction database