PTM - CPLM Gene Name UniProt ID Type Position Code UBE3C; KIAA0010; KIAA10 Q15386 Ubiquitination 9 K UBE3C; KIAA0010; KIAA10 Q15386 Ubiquitination 130 K UBE3C; KIAA0010; KIAA10 Q15386 Ubiquitination 235 K UBE3C; KIAA0010; KIAA10 Q15386 Ubiquitination 243 K UBE3C; KIAA0010; KIAA10 Q15386 Ubiquitination 558 K UBE3C; KIAA0010; KIAA10 Q15386 Ubiquitination 610 K UBE3C; KIAA0010; KIAA10 Q15386 Ubiquitination 638 K UBE3C; KIAA0010; KIAA10 Q15386 Ubiquitination 1013 K UBE3C; KIAA0010; KIAA10 Q15386 Ubiquitination 700 K UBE3C; KIAA0010; KIAA10 Q15386 Ubiquitination 63 K UBE3C; KIAA0010; KIAA10 Q15386 Ubiquitination 565 K UBE3C; KIAA0010; KIAA10 Q15386 Ubiquitination 402 K UBE3C; KIAA0010; KIAA10 Q15386 Ubiquitination 398 K UBE3C; KIAA0010; KIAA10 Q15386 Ubiquitination 145 K UBE3C; KIAA0010; KIAA10 Q15386 Ubiquitination 710 K UBE3C; KIAA0010; KIAA10 Q15386 Ubiquitination 739 K UBE3C; KIAA0010; KIAA10 Q15386 Ubiquitination 782 K UBE3C; KIAA0010; KIAA10 Q15386 Ubiquitination 907 K UBE3C; KIAA0010; KIAA10 Q15386 Ubiquitination 218 K UBE3C; KIAA0010; KIAA10 Q15386 Ubiquitination 749 K UBE3C; KIAA0010; KIAA10 Q15386 Ubiquitination 793 K UBE3C; KIAA0010; KIAA10 Q15386 Ubiquitination 1008 K UBE3C; KIAA0010; KIAA10 Q15386 Ubiquitination 1056 K

PTM - dbPAF Gene Name UniProt ID Position Type Species UBE3C; KIAA0010; KIAA10 Q15386 111 S Homo sapiens(Human) UBE3C; KIAA0010; KIAA10 Q15386 118 Y Homo sapiens(Human) UBE3C; KIAA0010; KIAA10 Q15386 135 S Homo sapiens(Human) UBE3C; KIAA0010; KIAA10 Q15386 15 S Homo sapiens(Human) UBE3C; KIAA0010; KIAA10 Q15386 221 S Homo sapiens(Human) UBE3C; KIAA0010; KIAA10 Q15386 225 Y Homo sapiens(Human) UBE3C; KIAA0010; KIAA10 Q15386 364 S Homo sapiens(Human) UBE3C; KIAA0010; KIAA10 Q15386 366 S Homo sapiens(Human) UBE3C; KIAA0010; KIAA10 Q15386 368 S Homo sapiens(Human) UBE3C; KIAA0010; KIAA10 Q15386 372 S Homo sapiens(Human) UBE3C; KIAA0010; KIAA10 Q15386 464 S Homo sapiens(Human) UBE3C; KIAA0010; KIAA10 Q15386 467 S Homo sapiens(Human) UBE3C; KIAA0010; KIAA10 Q15386 59 Y Homo sapiens(Human) UBE3C; KIAA0010; KIAA10 Q15386 66 Y Homo sapiens(Human) UBE3C; KIAA0010; KIAA10 Q15386 850 T Homo sapiens(Human) UBE3C; KIAA0010; KIAA10 Q15386 851 S Homo sapiens(Human)

PTM - PhosphositePlus UniProt ID MOD_RSD Type SITE_+/-7_AA Q15386 S15-p Phosphorylation FkTRPKVsLGGAsRK Q15386 S20-p Phosphorylation KVsLGGAsRKEEkAS Q15386 Y59-p Phosphorylation IQSFIRGyRDRKQQy Q15386 Y66-p Phosphorylation yRDRKQQySIQRSAF Q15386 S221-p Phosphorylation LINSkLPsSIEySDL Q15386 Y225-p Phosphorylation kLPsSIEySDLSRVP Q15386 S366-p Phosphorylation ASCHDSAsDSEEEsE Q15386 S372-p Phosphorylation AsDSEEEsEEADKPS Q15386 Y447-p Phosphorylation VPKVRLLySLAFNAR Q15386 S464-p Phosphorylation RHLWFLIsSMsTRMI Q15386 S467-p Phosphorylation WFLIsSMsTRMITGS Q15386 S672-p Phosphorylation TLDVGLEsPPLSVSE Q15386 S845-p Phosphorylation PFAGFFLsKLLGtsA Q15386 T850-p Phosphorylation FLsKLLGtsADVDIH Q15386 S851-p Phosphorylation LsKLLGtsADVDIHH Q15386 T1004-p Phosphorylation WRVVEGFtDEEkRKL Q15386 K9-ub Ubiquitination FSFEGDFkTRPKVsL Q15386 K25-ub Ubiquitination GAsRKEEkASLLHRT Q15386 K130-ub Ubiquitination KHSSLFVkQLDGSER Q15386 K218-ub Ubiquitination LYLLINSkLPsSIEy Q15386 K235-ub Ubiquitination LSRVPIAkILLENVL Q15386 K243-ub Ubiquitination ILLENVLkPLHFTYN Q15386 K402-ub Ubiquitination CLKKLDTkQQTNTLL Q15386 K558-ub Ubiquitination DACLGIIkLAYPETk Q15386 K565-ub Ubiquitination kLAYPETkPEVREEY Q15386 K610-ub Ubiquitination KVITNLVkMLKSRDT Q15386 K638-ub Ubiquitination QEDIKADkVTQLYVP Q15386 K710-ub Ubiquitination QRLIYADkQEVQGDG Q15386 K739-ub Ubiquitination IYEDAYDkLSPENEP Q15386 K749-ub Ubiquitination PENEPDLkKRIRVHL Q15386 K782-ub Ubiquitination EFLNELLkSGFNPNQ Q15386 K793-ub Ubiquitination NPNQGFFkTTNEGLL Q15386 K907-ub Ubiquitination VELKFGGkDIPVTSA Q15386 K1008-ub Ubiquitination EGFtDEEkRKLLKFV

PTM - dbPTM UniProt ID Position Code Type Resources References Q15386 1008 K Ubiquitylation Phosphositeplus.1010730 21906983 Q15386 130 K Ubiquitylation Phosphositeplus.1010730 21890473;21906983 Q15386 218 K Ubiquitylation Phosphositeplus.1010730 21906983 Q15386 235 K Ubiquitylation Phosphositeplus.1010730 21890473 Q15386 243 K Ubiquitylation Phosphositeplus.1010730 21890473 Q15386 25 K Ubiquitylation Phosphositeplus.1010730 20972266 Q15386 402 K Ubiquitylation Phosphositeplus.1010730 21906983 Q15386 558 K Ubiquitylation Phosphositeplus.1010730 21890473 Q15386 565 K Ubiquitylation Phosphositeplus.1010730 21906983 Q15386 610 K Ubiquitylation Phosphositeplus.1010730 21890473 Q15386 638 K Ubiquitylation Phosphositeplus.1010730 21890473;21906983 Q15386 710 K Ubiquitylation Phosphositeplus.1010730 21906983 Q15386 739 K Ubiquitylation Phosphositeplus.1010730 21906983 Q15386 749 K Ubiquitylation Phosphositeplus.1010730 21906983 Q15386 782 K Ubiquitylation Phosphositeplus.1010730 21906983 Q15386 793 K Ubiquitylation Phosphositeplus.1010730 21906983 Q15386 9 K Ubiquitylation Phosphositeplus.1010730 21890473 Q15386 907 K Ubiquitylation Phosphositeplus.1010730 21906983

PTM - BioGRID Entrez Gene BioGRID ID Position Code Type PMIDs 9690 115043 - K Ubiquitination 16196087 9690 115043 - K Ubiquitination 20972266 9690 115043 - K Ubiquitination 21139048 9690 115043 - K Ubiquitination 21890473 9690 115043 - K Ubiquitination 21906983 9690 115043 - K Ubiquitination 21963094 9690 115043 - K Ubiquitination 24816145 9690 115043 - K Ubiquitination 25147182

PTM - mUbiSiDa Gene Name Species Ubiquitination Site Ubiquitination Sequence Evidence PMID UBE3C Homo sapiens (Human) 610; 235; 558; 9; 130; 243; 638 "610,VITNLVKMLKSRD; 235,SRVPIAKILLENV; 558,ACLGIIKLAYPET; 9,SFEGDFKTRPKVS; 130,HSSLFVKQLDGSE; 243,LLENVLKPLHFTY; 638,EDIKADKVTQLYV" 610:21890473; 235:21890473; 558:21890473; 9:21890473; 130:21890473; 243:21890473; 638:21890473 UBE3C Homo sapiens (Human) 610; 565; 235; 218; 402; 558; 9; 130; 243 "610,VITNLVKMLKSRD; 565,LAYPETKPEVREE; 235,SRVPIAKILLENV; 218,YLLINSKLPSSIE; 402,LKKLDTKQQTNTL; 558,ACLGIIKLAYPET; 9,SFEGDFKTRPKVS; 130,HSSLFVKQLDGSE; 243,LLENVLKPLHFTY" "610:21890473; 565:21906983; 235:21890473; 218:21906983; 402:21906983; 558:21890473; 9:21890473; 130:21890473,21906983; 243:21890473" UBE3C Homo sapiens (Human) 610; 235; 749; 1008; 402; 558; 739; 130; 793; 710; 565; 907; 218; 782; 638; 243 "610,VITNLVKMLKSRD; 235,SRVPIAKILLENV; 749,ENEPDLKKRIRVH; 1008,GFTDEEKRKLLKF; 402,LKKLDTKQQTNTL; 558,ACLGIIKLAYPET; 739,YEDAYDKLSPENE; 130,HSSLFVKQLDGSE; 793,PNQGFFKTTNEGL; 710,RLIYADKQEVQGD; 565,LAYPETKPEVREE; 907,ELKFGGKDIPVTS; 218,YLLINSKLPSSIE; 782,FLNELLKSGFNPN; 638,EDIKADKVTQLYV; 243,LLENVLKPLHFTY" "610:21890473; 235:21890473; 749:21906983; 1008:21906983; 402:21906983; 558:21890473; 739:21906983; 130:21890473,21906983; 793:21906983; 710:21906983; 565:21906983; 907:21906983; 218:21906983; 782:21906983; 638:21890473,21906983; 243:21890473" UBE3C Homo sapiens (Human) 87; 359; 175; 200; 192 "87,HSSLFVKQLDGSE; 359,LKKLDTKQQTNTL; 175,YLLINSKLPSSIE; 200,LLENVLKPLHFTY; 192,SRVPIAKILLENV" "87:21890473,21906983; 359:21906983; 175:21906983; 200:21890473; 192:21890473" UBE3C Homo sapiens (Human) 25 "25,ASRKEEKASLLHR" 25:20972266