PTM - CPLM Gene Name UniProt ID Type Position Code BRCA1; RNF53 P38398 Sumoylation 32 K BRCA1; RNF53 P38398 Sumoylation 1690 K BRCA1; RNF53 P38398 Sumoylation 109 K BRCA1; RNF53 P38398 Sumoylation 119 K BRCA1; RNF53 P38398 Ubiquitination 50 K BRCA1; RNF53 P38398 Ubiquitination 987 K BRCA1; RNF53 P38398 Ubiquitination 1667 K

PTM - dbPAF Gene Name UniProt ID Position Type Species BRCA1; RNF53 P38398 1007 S Homo sapiens(Human) BRCA1; RNF53 P38398 1009 S Homo sapiens(Human) BRCA1; RNF53 P38398 1050 S Homo sapiens(Human) BRCA1; RNF53 P38398 1101 S Homo sapiens(Human) BRCA1; RNF53 P38398 114 S Homo sapiens(Human) BRCA1; RNF53 P38398 1140 S Homo sapiens(Human) BRCA1; RNF53 P38398 1143 S Homo sapiens(Human) BRCA1; RNF53 P38398 1149 T Homo sapiens(Human) BRCA1; RNF53 P38398 1163 T Homo sapiens(Human) BRCA1; RNF53 P38398 1164 S Homo sapiens(Human) BRCA1; RNF53 P38398 1174 S Homo sapiens(Human) BRCA1; RNF53 P38398 1178 S Homo sapiens(Human) BRCA1; RNF53 P38398 1187 S Homo sapiens(Human) BRCA1; RNF53 P38398 1189 S Homo sapiens(Human) BRCA1; RNF53 P38398 1191 S Homo sapiens(Human) BRCA1; RNF53 P38398 1194 T Homo sapiens(Human) BRCA1; RNF53 P38398 1196 T Homo sapiens(Human) BRCA1; RNF53 P38398 1202 Y Homo sapiens(Human) BRCA1; RNF53 P38398 1211 S Homo sapiens(Human) BRCA1; RNF53 P38398 1212 S Homo sapiens(Human) BRCA1; RNF53 P38398 1217 S Homo sapiens(Human) BRCA1; RNF53 P38398 1218 S Homo sapiens(Human) BRCA1; RNF53 P38398 123 S Homo sapiens(Human) BRCA1; RNF53 P38398 1239 S Homo sapiens(Human) BRCA1; RNF53 P38398 1241 S Homo sapiens(Human) BRCA1; RNF53 P38398 1245 S Homo sapiens(Human) BRCA1; RNF53 P38398 1253 S Homo sapiens(Human) BRCA1; RNF53 P38398 1266 S Homo sapiens(Human) BRCA1; RNF53 P38398 1271 S Homo sapiens(Human) BRCA1; RNF53 P38398 1280 S Homo sapiens(Human) BRCA1; RNF53 P38398 1286 S Homo sapiens(Human) BRCA1; RNF53 P38398 1289 T Homo sapiens(Human) BRCA1; RNF53 P38398 1301 S Homo sapiens(Human) BRCA1; RNF53 P38398 1328 S Homo sapiens(Human) BRCA1; RNF53 P38398 1330 S Homo sapiens(Human) BRCA1; RNF53 P38398 1336 S Homo sapiens(Human) BRCA1; RNF53 P38398 1342 S Homo sapiens(Human) BRCA1; RNF53 P38398 1387 S Homo sapiens(Human) BRCA1; RNF53 P38398 1394 T Homo sapiens(Human) BRCA1; RNF53 P38398 1423 S Homo sapiens(Human) BRCA1; RNF53 P38398 1450 S Homo sapiens(Human) BRCA1; RNF53 P38398 1457 S Homo sapiens(Human) BRCA1; RNF53 P38398 1460 S Homo sapiens(Human) BRCA1; RNF53 P38398 1461 S Homo sapiens(Human) BRCA1; RNF53 P38398 1463 Y Homo sapiens(Human) BRCA1; RNF53 P38398 1466 S Homo sapiens(Human) BRCA1; RNF53 P38398 1473 S Homo sapiens(Human) BRCA1; RNF53 P38398 1480 S Homo sapiens(Human) BRCA1; RNF53 P38398 1483 S Homo sapiens(Human) BRCA1; RNF53 P38398 1484 S Homo sapiens(Human) BRCA1; RNF53 P38398 1485 T Homo sapiens(Human) BRCA1; RNF53 P38398 1486 S Homo sapiens(Human) BRCA1; RNF53 P38398 1496 S Homo sapiens(Human) BRCA1; RNF53 P38398 1497 S Homo sapiens(Human) BRCA1; RNF53 P38398 1499 S Homo sapiens(Human) BRCA1; RNF53 P38398 1503 S Homo sapiens(Human) BRCA1; RNF53 P38398 1524 S Homo sapiens(Human) BRCA1; RNF53 P38398 1542 S Homo sapiens(Human) BRCA1; RNF53 P38398 1548 T Homo sapiens(Human) BRCA1; RNF53 P38398 1550 T Homo sapiens(Human) BRCA1; RNF53 P38398 1572 S Homo sapiens(Human) BRCA1; RNF53 P38398 1577 S Homo sapiens(Human) BRCA1; RNF53 P38398 1596 S Homo sapiens(Human) BRCA1; RNF53 P38398 1598 S Homo sapiens(Human) BRCA1; RNF53 P38398 1613 S Homo sapiens(Human) BRCA1; RNF53 P38398 1619 T Homo sapiens(Human) BRCA1; RNF53 P38398 1620 T Homo sapiens(Human) BRCA1; RNF53 P38398 1622 T Homo sapiens(Human) BRCA1; RNF53 P38398 164 T Homo sapiens(Human) BRCA1; RNF53 P38398 1642 S Homo sapiens(Human) BRCA1; RNF53 P38398 1643 T Homo sapiens(Human) BRCA1; RNF53 P38398 1681 T Homo sapiens(Human) BRCA1; RNF53 P38398 1700 T Homo sapiens(Human) BRCA1; RNF53 P38398 1720 T Homo sapiens(Human) BRCA1; RNF53 P38398 1777 T Homo sapiens(Human) BRCA1; RNF53 P38398 1790 S Homo sapiens(Human) BRCA1; RNF53 P38398 208 T Homo sapiens(Human) BRCA1; RNF53 P38398 220 S Homo sapiens(Human) BRCA1; RNF53 P38398 281 S Homo sapiens(Human) BRCA1; RNF53 P38398 308 S Homo sapiens(Human) BRCA1; RNF53 P38398 316 S Homo sapiens(Human) BRCA1; RNF53 P38398 324 S Homo sapiens(Human) BRCA1; RNF53 P38398 374 T Homo sapiens(Human) BRCA1; RNF53 P38398 377 S Homo sapiens(Human) BRCA1; RNF53 P38398 378 S Homo sapiens(Human) BRCA1; RNF53 P38398 387 S Homo sapiens(Human) BRCA1; RNF53 P38398 395 S Homo sapiens(Human) BRCA1; RNF53 P38398 398 S Homo sapiens(Human) BRCA1; RNF53 P38398 403 S Homo sapiens(Human) BRCA1; RNF53 P38398 405 S Homo sapiens(Human) BRCA1; RNF53 P38398 423 S Homo sapiens(Human) BRCA1; RNF53 P38398 425 S Homo sapiens(Human) BRCA1; RNF53 P38398 426 S Homo sapiens(Human) BRCA1; RNF53 P38398 434 S Homo sapiens(Human) BRCA1; RNF53 P38398 451 S Homo sapiens(Human) BRCA1; RNF53 P38398 454 S Homo sapiens(Human) BRCA1; RNF53 P38398 509 T Homo sapiens(Human) BRCA1; RNF53 P38398 510 S Homo sapiens(Human) BRCA1; RNF53 P38398 551 S Homo sapiens(Human) BRCA1; RNF53 P38398 615 S Homo sapiens(Human) BRCA1; RNF53 P38398 616 S Homo sapiens(Human) BRCA1; RNF53 P38398 617 T Homo sapiens(Human) BRCA1; RNF53 P38398 632 S Homo sapiens(Human) BRCA1; RNF53 P38398 637 T Homo sapiens(Human) BRCA1; RNF53 P38398 647 S Homo sapiens(Human) BRCA1; RNF53 P38398 694 S Homo sapiens(Human) BRCA1; RNF53 P38398 696 T Homo sapiens(Human) BRCA1; RNF53 P38398 708 S Homo sapiens(Human) BRCA1; RNF53 P38398 710 T Homo sapiens(Human) BRCA1; RNF53 P38398 72 S Homo sapiens(Human) BRCA1; RNF53 P38398 741 S Homo sapiens(Human) BRCA1; RNF53 P38398 753 S Homo sapiens(Human) BRCA1; RNF53 P38398 76 S Homo sapiens(Human) BRCA1; RNF53 P38398 77 T Homo sapiens(Human) BRCA1; RNF53 P38398 803 S Homo sapiens(Human) BRCA1; RNF53 P38398 840 S Homo sapiens(Human) BRCA1; RNF53 P38398 868 S Homo sapiens(Human) BRCA1; RNF53 P38398 889 S Homo sapiens(Human) BRCA1; RNF53 P38398 967 T Homo sapiens(Human) BRCA1; RNF53 P38398 978 Y Homo sapiens(Human) BRCA1; RNF53 P38398 988 S Homo sapiens(Human)

PTM - PhosSNP Gene Name dbSNP ID Gene Mutation AA Mutation Mutation Position Code Peptide Score Modification Type BRCA1; RNF53 rs41293457 TCT->TGT S->C 1542 S EEQQLEESGPHDLTE 1542 Phosphorylation TypeI- BRCA1; RNF53 rs45564238 ACC->GCC T->A 617 T RLRRKSSTRHIHALE 617 Phosphorylation TypeI- BRCA1; RNF53 rs55767801 AGC->GGC S->G 308 S KAEFCNKSKQPGLAR 308 Phosphorylation: Aurora A TypeI- BRCA1; RNF53 rs41293457 TCT->TGT S->C 1542 S EEQQLEESGPHDLTE 1542 Phosphorylation TypeI- BRCA1; RNF53 rs45564238 ACC->GCC T->A 617 T RLRRKSSTRHIHALE 617 Phosphorylation TypeI- BRCA1; RNF53 rs55767801 AGC->GGC S->G 308 S KAEFCNKSKQPGLAR 308 Phosphorylation: Aurora A TypeI- BRCA1; RNF53 rs41293457 TCT->TGT S->C 1542 S EEQQLEESGPHDLTE 1542 Phosphorylation TypeI- BRCA1; RNF53 rs45564238 ACC->GCC T->A 617 T RLRRKSSTRHIHALE 617 Phosphorylation TypeI- BRCA1; RNF53 rs55767801 AGC->GGC S->G 308 S KAEFCNKSKQPGLAR 308 Phosphorylation: Aurora A TypeI- BRCA1; RNF53 rs41293457 TCT->TGT S->C 1246 S EEQQLEESGPHDLTE 1542 Phosphorylation TypeI- BRCA1; RNF53 rs45564238 ACC->GCC T->A 321 T RLRRKSSTRHIHALE 617 Phosphorylation TypeI- BRCA1; RNF53 rs55767801 AGC->GGC S->G 12 S KAEFCNKSKQPGLAR 308 Phosphorylation: Aurora A TypeI- BRCA1; RNF53 rs41293457 TCT->TGT S->C 359 S EEQQLEESGPHDLTE 1542 Phosphorylation TypeI- BRCA1; RNF53 rs45564238 ACC->GCC T->A 617 T RLRRKSSTRHIHALE 617 Phosphorylation TypeI- BRCA1; RNF53 rs55767801 AGC->GGC S->G 308 S KAEFCNKSKQPGLAR 308 Phosphorylation: Aurora A TypeI- BRCA1; RNF53 rs45564238 ACC->GCC T->A 617 T RLRRKSSTRHIHALE 617 Phosphorylation TypeI- BRCA1; RNF53 rs55767801 AGC->GGC S->G 308 S KAEFCNKSKQPGLAR 308 Phosphorylation: Aurora A TypeI- BRCA1; RNF53 rs41293457 TCT->TGT S->C 1501 S EEQQLEESGPHDLTE 1542 Phosphorylation TypeI- BRCA1; RNF53 rs45564238 ACC->GCC T->A 576 T RLRRKSSTRHIHALE 617 Phosphorylation TypeI- BRCA1; RNF53 rs55767801 AGC->GGC S->G 267 S KAEFCNKSKQPGLAR 308 Phosphorylation: Aurora A TypeI- BRCA1; RNF53 rs41293457 TCT->TGT S->C 400 S EEQQLEESGPHDLTE 1542 Phosphorylation TypeI- BRCA1; RNF53 rs41293457 TCT->TGT S->C 438 S EEQQLEESGPHDLTE 1542 Phosphorylation TypeI- BRCA1; RNF53 rs41293457 TCT->TGT S->C 398 S EEQQLEESGPHDLTE 1542 Phosphorylation TypeI- BRCA1; RNF53 rs16942 AAA->AGA K->R 1189 S QKGELSRSPSPFTHT 1189 Phosphorylation TypeIII- BRCA1; RNF53 rs28897686 GAG->AAG E->K 1245 S PSQSTRHSTVATECL 1245 Phosphorylation TypeIII- BRCA1; RNF53 rs28897687 AAT->AAG N->K 1239 S GKVNNIPSQSTRHST 1239 Phosphorylation TypeIII- BRCA1; RNF53 rs28897688 CCT->CTT P->L 1239 S GKVNNIPSQSTRHST 1239 Phosphorylation TypeIII- BRCA1; RNF53 rs28897688 CCT->CTT P->L 1245 S PSQSTRHSTVATECL 1245 Phosphorylation TypeIII- BRCA1; RNF53 rs28897691 GAT->AAT D->N 1542 S EEQQLEESGPHDLTE 1542 Phosphorylation TypeIII- BRCA1; RNF53 rs41286294 CTT->TTT L->F 509 T LKRKRRPTSGLHPED 509 Phosphorylation: PKB_group TypeIII- BRCA1; RNF53 rs41286294 CTT->TTT L->F 510 S KRKRRPTSGLHPEDF 510 Phosphorylation TypeIII- BRCA1; RNF53 rs45564238 ACC->GCC T->A 615 S KNRLRRKSSTRHIHA 615 Phosphorylation TypeIII- BRCA1; RNF53 rs4986848 TTT->TCT F->S 988 S PPLFPIKSFVKTKCK 988 Phosphorylation: CHK2 TypeIII- BRCA1; RNF53 rs55886745 CCA->CAA P->Q 1497 S EPGVERSSPSKCPSL 1497 Phosphorylation: CDK2; CDK_group TypeIII- BRCA1; RNF53 rs56032833 GGA->CGA G->R 1330 S QMRHQSESQGVGLSD 1330 Phosphorylation TypeIII- BRCA1; RNF53 rs56032833 GGA->CGA G->R 1336 S ESQGVGLSDKELVSD 1336 Phosphorylation TypeIII- BRCA1; RNF53 rs56039126 GCG->GTG A->V 615 S KNRLRRKSSTRHIHA 615 Phosphorylation TypeIII- BRCA1; RNF53 rs56100707 CCT->CGT P->R 509 T LKRKRRPTSGLHPED 509 Phosphorylation: PKB_group TypeIII- BRCA1; RNF53 rs56100707 CCT->CGT P->R 510 S KRKRRPTSGLHPEDF 510 Phosphorylation TypeIII- BRCA1; RNF53 rs56272539 CGT->CAT R->H 509 T LKRKRRPTSGLHPED 509 Phosphorylation: PKB_group TypeIII- BRCA1; RNF53 rs56272539 CGT->CAT R->H 510 S KRKRRPTSGLHPEDF 510 Phosphorylation TypeIII- BRCA1; RNF53 rs56335406 CCA->CTA P->L 1497 S EPGVERSSPSKCPSL 1497 Phosphorylation: CDK2; CDK_group TypeIII- BRCA1; RNF53 rs56335406 CCA->CTA P->L 1499 S GVERSSPSKCPSLDD 1499 Phosphorylation TypeIII- BRCA1; RNF53 rs62625304 AAG->AGG K->R 509 T LKRKRRPTSGLHPED 509 Phosphorylation: PKB_group TypeIII- BRCA1; RNF53 rs16942 AAA->AGA K->R 1189 S QKGELSRSPSPFTHT 1189 Phosphorylation TypeIII- BRCA1; RNF53 rs28897686 GAG->AAG E->K 1245 S PSQSTRHSTVATECL 1245 Phosphorylation TypeIII- BRCA1; RNF53 rs28897687 AAT->AAG N->K 1239 S GKVNNIPSQSTRHST 1239 Phosphorylation TypeIII- BRCA1; RNF53 rs28897688 CCT->CTT P->L 1239 S GKVNNIPSQSTRHST 1239 Phosphorylation TypeIII- BRCA1; RNF53 rs28897688 CCT->CTT P->L 1245 S PSQSTRHSTVATECL 1245 Phosphorylation TypeIII- BRCA1; RNF53 rs28897691 GAT->AAT D->N 1542 S EEQQLEESGPHDLTE 1542 Phosphorylation TypeIII- BRCA1; RNF53 rs41286294 CTT->TTT L->F 509 T LKRKRRPTSGLHPED 509 Phosphorylation: PKB_group TypeIII- BRCA1; RNF53 rs41286294 CTT->TTT L->F 510 S KRKRRPTSGLHPEDF 510 Phosphorylation TypeIII- BRCA1; RNF53 rs45564238 ACC->GCC T->A 615 S KNRLRRKSSTRHIHA 615 Phosphorylation TypeIII- BRCA1; RNF53 rs4986848 TTT->TCT F->S 988 S PPLFPIKSFVKTKCK 988 Phosphorylation: CHK2 TypeIII- BRCA1; RNF53 rs55886745 CCA->CAA P->Q 1497 S EPGVERSSPSKCPSL 1497 Phosphorylation: CDK2; CDK_group TypeIII- BRCA1; RNF53 rs56032833 GGA->CGA G->R 1330 S QMRHQSESQGVGLSD 1330 Phosphorylation TypeIII- BRCA1; RNF53 rs56032833 GGA->CGA G->R 1336 S ESQGVGLSDKELVSD 1336 Phosphorylation TypeIII- BRCA1; RNF53 rs56039126 GCG->GTG A->V 615 S KNRLRRKSSTRHIHA 615 Phosphorylation TypeIII- BRCA1; RNF53 rs56100707 CCT->CGT P->R 509 T LKRKRRPTSGLHPED 509 Phosphorylation: PKB_group TypeIII- BRCA1; RNF53 rs56100707 CCT->CGT P->R 510 S KRKRRPTSGLHPEDF 510 Phosphorylation TypeIII- BRCA1; RNF53 rs56272539 CGT->CAT R->H 509 T LKRKRRPTSGLHPED 509 Phosphorylation: PKB_group TypeIII- BRCA1; RNF53 rs56272539 CGT->CAT R->H 510 S KRKRRPTSGLHPEDF 510 Phosphorylation TypeIII- BRCA1; RNF53 rs56335406 CCA->CTA P->L 1497 S EPGVERSSPSKCPSL 1497 Phosphorylation: CDK2; CDK_group TypeIII- BRCA1; RNF53 rs56335406 CCA->CTA P->L 1499 S GVERSSPSKCPSLDD 1499 Phosphorylation TypeIII- BRCA1; RNF53 rs62625304 AAG->AGG K->R 509 T LKRKRRPTSGLHPED 509 Phosphorylation: PKB_group TypeIII- BRCA1; RNF53 rs16942 AAA->AGA K->R 1189 S QKGELSRSPSPFTHT 1189 Phosphorylation TypeIII- BRCA1; RNF53 rs28897686 GAG->AAG E->K 1245 S PSQSTRHSTVATECL 1245 Phosphorylation TypeIII- BRCA1; RNF53 rs28897687 AAT->AAG N->K 1239 S GKVNNIPSQSTRHST 1239 Phosphorylation TypeIII- BRCA1; RNF53 rs28897688 CCT->CTT P->L 1239 S GKVNNIPSQSTRHST 1239 Phosphorylation TypeIII- BRCA1; RNF53 rs28897688 CCT->CTT P->L 1245 S PSQSTRHSTVATECL 1245 Phosphorylation TypeIII- BRCA1; RNF53 rs28897691 GAT->AAT D->N 1542 S EEQQLEESGPHDLTE 1542 Phosphorylation TypeIII- BRCA1; RNF53 rs41286294 CTT->TTT L->F 509 T LKRKRRPTSGLHPED 509 Phosphorylation: PKB_group TypeIII- BRCA1; RNF53 rs41286294 CTT->TTT L->F 510 S KRKRRPTSGLHPEDF 510 Phosphorylation TypeIII- BRCA1; RNF53 rs45564238 ACC->GCC T->A 615 S KNRLRRKSSTRHIHA 615 Phosphorylation TypeIII- BRCA1; RNF53 rs4986848 TTT->TCT F->S 988 S PPLFPIKSFVKTKCK 988 Phosphorylation: CHK2 TypeIII- BRCA1; RNF53 rs55886745 CCA->CAA P->Q 1497 S EPGVERSSPSKCPSL 1497 Phosphorylation: CDK2; CDK_group TypeIII- BRCA1; RNF53 rs56032833 GGA->CGA G->R 1330 S QMRHQSESQGVGLSD 1330 Phosphorylation TypeIII- BRCA1; RNF53 rs56032833 GGA->CGA G->R 1336 S ESQGVGLSDKELVSD 1336 Phosphorylation TypeIII- BRCA1; RNF53 rs56039126 GCG->GTG A->V 615 S KNRLRRKSSTRHIHA 615 Phosphorylation TypeIII- BRCA1; RNF53 rs56100707 CCT->CGT P->R 509 T LKRKRRPTSGLHPED 509 Phosphorylation: PKB_group TypeIII- BRCA1; RNF53 rs56100707 CCT->CGT P->R 510 S KRKRRPTSGLHPEDF 510 Phosphorylation TypeIII- BRCA1; RNF53 rs56272539 CGT->CAT R->H 509 T LKRKRRPTSGLHPED 509 Phosphorylation: PKB_group TypeIII- BRCA1; RNF53 rs56272539 CGT->CAT R->H 510 S KRKRRPTSGLHPEDF 510 Phosphorylation TypeIII- BRCA1; RNF53 rs56335406 CCA->CTA P->L 1497 S EPGVERSSPSKCPSL 1497 Phosphorylation: CDK2; CDK_group TypeIII- BRCA1; RNF53 rs56335406 CCA->CTA P->L 1499 S GVERSSPSKCPSLDD 1499 Phosphorylation TypeIII- BRCA1; RNF53 rs62625304 AAG->AGG K->R 509 T LKRKRRPTSGLHPED 509 Phosphorylation: PKB_group TypeIII- BRCA1; RNF53 rs16942 AAA->AGA K->R 893 S QKGELSRSPSPFTHT 1189 Phosphorylation TypeIII- BRCA1; RNF53 rs28897686 GAG->AAG E->K 949 S PSQSTRHSTVATECL 1245 Phosphorylation TypeIII- BRCA1; RNF53 rs28897687 AAT->AAG N->K 943 S GKVNNIPSQSTRHST 1239 Phosphorylation TypeIII- BRCA1; RNF53 rs28897688 CCT->CTT P->L 943 S GKVNNIPSQSTRHST 1239 Phosphorylation TypeIII- BRCA1; RNF53 rs28897688 CCT->CTT P->L 949 S PSQSTRHSTVATECL 1245 Phosphorylation TypeIII- BRCA1; RNF53 rs28897691 GAT->AAT D->N 1246 S EEQQLEESGPHDLTE 1542 Phosphorylation TypeIII- BRCA1; RNF53 rs41286294 CTT->TTT L->F 213 T LKRKRRPTSGLHPED 509 Phosphorylation: PKB_group TypeIII- BRCA1; RNF53 rs41286294 CTT->TTT L->F 214 S KRKRRPTSGLHPEDF 510 Phosphorylation TypeIII- BRCA1; RNF53 rs45564238 ACC->GCC T->A 319 S KNRLRRKSSTRHIHA 615 Phosphorylation TypeIII- BRCA1; RNF53 rs4986848 TTT->TCT F->S 692 S PPLFPIKSFVKTKCK 988 Phosphorylation: CHK2 TypeIII- BRCA1; RNF53 rs55886745 CCA->CAA P->Q 1201 S EPGVERSSPSKCPSL 1497 Phosphorylation: CDK2; CDK_group TypeIII- BRCA1; RNF53 rs56032833 GGA->CGA G->R 1034 S QMRHQSESQGVGLSD 1330 Phosphorylation TypeIII- BRCA1; RNF53 rs56032833 GGA->CGA G->R 1040 S ESQGVGLSDKELVSD 1336 Phosphorylation TypeIII- BRCA1; RNF53 rs56039126 GCG->GTG A->V 319 S KNRLRRKSSTRHIHA 615 Phosphorylation TypeIII- BRCA1; RNF53 rs56100707 CCT->CGT P->R 213 T LKRKRRPTSGLHPED 509 Phosphorylation: PKB_group TypeIII- BRCA1; RNF53 rs56100707 CCT->CGT P->R 214 S KRKRRPTSGLHPEDF 510 Phosphorylation TypeIII- BRCA1; RNF53 rs56272539 CGT->CAT R->H 213 T LKRKRRPTSGLHPED 509 Phosphorylation: PKB_group TypeIII- BRCA1; RNF53 rs56272539 CGT->CAT R->H 214 S KRKRRPTSGLHPEDF 510 Phosphorylation TypeIII- BRCA1; RNF53 rs56335406 CCA->CTA P->L 1201 S EPGVERSSPSKCPSL 1497 Phosphorylation: CDK2; CDK_group TypeIII- BRCA1; RNF53 rs56335406 CCA->CTA P->L 1203 S GVERSSPSKCPSLDD 1499 Phosphorylation TypeIII- BRCA1; RNF53 rs62625304 AAG->AGG K->R 213 T LKRKRRPTSGLHPED 509 Phosphorylation: PKB_group TypeIII- BRCA1; RNF53 rs28897691 GAT->AAT D->N 359 S EEQQLEESGPHDLTE 1542 Phosphorylation TypeIII- BRCA1; RNF53 rs55886745 CCA->CAA P->Q 314 S EPGVERSSPSKCPSL 1497 Phosphorylation: CDK2; CDK_group TypeIII- BRCA1; RNF53 rs56335406 CCA->CTA P->L 314 S EPGVERSSPSKCPSL 1497 Phosphorylation: CDK2; CDK_group TypeIII- BRCA1; RNF53 rs56335406 CCA->CTA P->L 316 S GVERSSPSKCPSLDD 1499 Phosphorylation TypeIII- BRCA1; RNF53 rs16942 AAA->AGA K->R 1189 S QKGELSRSPSPFTHT 1189 Phosphorylation TypeIII- BRCA1; RNF53 rs28897686 GAG->AAG E->K 1245 S PSQSTRHSTVATECL 1245 Phosphorylation TypeIII- BRCA1; RNF53 rs28897687 AAT->AAG N->K 1239 S GKVNNIPSQSTRHST 1239 Phosphorylation TypeIII- BRCA1; RNF53 rs28897688 CCT->CTT P->L 1239 S GKVNNIPSQSTRHST 1239 Phosphorylation TypeIII- BRCA1; RNF53 rs28897688 CCT->CTT P->L 1245 S PSQSTRHSTVATECL 1245 Phosphorylation TypeIII- BRCA1; RNF53 rs41286294 CTT->TTT L->F 509 T LKRKRRPTSGLHPED 509 Phosphorylation: PKB_group TypeIII- BRCA1; RNF53 rs41286294 CTT->TTT L->F 510 S KRKRRPTSGLHPEDF 510 Phosphorylation TypeIII- BRCA1; RNF53 rs45564238 ACC->GCC T->A 615 S KNRLRRKSSTRHIHA 615 Phosphorylation TypeIII- BRCA1; RNF53 rs4986848 TTT->TCT F->S 988 S PPLFPIKSFVKTKCK 988 Phosphorylation: CHK2 TypeIII- BRCA1; RNF53 rs56032833 GGA->CGA G->R 1330 S QMRHQSESQGVGLSD 1330 Phosphorylation TypeIII- BRCA1; RNF53 rs56032833 GGA->CGA G->R 1336 S ESQGVGLSDKELVSD 1336 Phosphorylation TypeIII- BRCA1; RNF53 rs56039126 GCG->GTG A->V 615 S KNRLRRKSSTRHIHA 615 Phosphorylation TypeIII- BRCA1; RNF53 rs56100707 CCT->CGT P->R 509 T LKRKRRPTSGLHPED 509 Phosphorylation: PKB_group TypeIII- BRCA1; RNF53 rs56100707 CCT->CGT P->R 510 S KRKRRPTSGLHPEDF 510 Phosphorylation TypeIII- BRCA1; RNF53 rs56272539 CGT->CAT R->H 509 T LKRKRRPTSGLHPED 509 Phosphorylation: PKB_group TypeIII- BRCA1; RNF53 rs56272539 CGT->CAT R->H 510 S KRKRRPTSGLHPEDF 510 Phosphorylation TypeIII- BRCA1; RNF53 rs62625304 AAG->AGG K->R 509 T LKRKRRPTSGLHPED 509 Phosphorylation: PKB_group TypeIII- BRCA1; RNF53 rs16942 AAA->AGA K->R 1189 S QKGELSRSPSPFTHT 1189 Phosphorylation TypeIII- BRCA1; RNF53 rs28897686 GAG->AAG E->K 1245 S PSQSTRHSTVATECL 1245 Phosphorylation TypeIII- BRCA1; RNF53 rs28897687 AAT->AAG N->K 1239 S GKVNNIPSQSTRHST 1239 Phosphorylation TypeIII- BRCA1; RNF53 rs28897688 CCT->CTT P->L 1239 S GKVNNIPSQSTRHST 1239 Phosphorylation TypeIII- BRCA1; RNF53 rs28897688 CCT->CTT P->L 1245 S PSQSTRHSTVATECL 1245 Phosphorylation TypeIII- BRCA1; RNF53 rs41286294 CTT->TTT L->F 509 T LKRKRRPTSGLHPED 509 Phosphorylation: PKB_group TypeIII- BRCA1; RNF53 rs41286294 CTT->TTT L->F 510 S KRKRRPTSGLHPEDF 510 Phosphorylation TypeIII- BRCA1; RNF53 rs45564238 ACC->GCC T->A 615 S KNRLRRKSSTRHIHA 615 Phosphorylation TypeIII- BRCA1; RNF53 rs4986848 TTT->TCT F->S 988 S PPLFPIKSFVKTKCK 988 Phosphorylation: CHK2 TypeIII- BRCA1; RNF53 rs56032833 GGA->CGA G->R 1330 S QMRHQSESQGVGLSD 1330 Phosphorylation TypeIII- BRCA1; RNF53 rs56032833 GGA->CGA G->R 1336 S ESQGVGLSDKELVSD 1336 Phosphorylation TypeIII- BRCA1; RNF53 rs56039126 GCG->GTG A->V 615 S KNRLRRKSSTRHIHA 615 Phosphorylation TypeIII- BRCA1; RNF53 rs56100707 CCT->CGT P->R 509 T LKRKRRPTSGLHPED 509 Phosphorylation: PKB_group TypeIII- BRCA1; RNF53 rs56100707 CCT->CGT P->R 510 S KRKRRPTSGLHPEDF 510 Phosphorylation TypeIII- BRCA1; RNF53 rs56272539 CGT->CAT R->H 509 T LKRKRRPTSGLHPED 509 Phosphorylation: PKB_group TypeIII- BRCA1; RNF53 rs56272539 CGT->CAT R->H 510 S KRKRRPTSGLHPEDF 510 Phosphorylation TypeIII- BRCA1; RNF53 rs62625304 AAG->AGG K->R 509 T LKRKRRPTSGLHPED 509 Phosphorylation: PKB_group TypeIII- BRCA1; RNF53 rs16942 AAA->AGA K->R 1148 S QKGELSRSPSPFTHT 1189 Phosphorylation TypeIII- BRCA1; RNF53 rs28897686 GAG->AAG E->K 1204 S PSQSTRHSTVATECL 1245 Phosphorylation TypeIII- BRCA1; RNF53 rs28897687 AAT->AAG N->K 1198 S GKVNNIPSQSTRHST 1239 Phosphorylation TypeIII- BRCA1; RNF53 rs28897688 CCT->CTT P->L 1198 S GKVNNIPSQSTRHST 1239 Phosphorylation TypeIII- BRCA1; RNF53 rs28897688 CCT->CTT P->L 1204 S PSQSTRHSTVATECL 1245 Phosphorylation TypeIII- BRCA1; RNF53 rs28897691 GAT->AAT D->N 1501 S EEQQLEESGPHDLTE 1542 Phosphorylation TypeIII- BRCA1; RNF53 rs41286294 CTT->TTT L->F 468 T LKRKRRPTSGLHPED 509 Phosphorylation: PKB_group TypeIII- BRCA1; RNF53 rs41286294 CTT->TTT L->F 469 S KRKRRPTSGLHPEDF 510 Phosphorylation TypeIII- BRCA1; RNF53 rs45564238 ACC->GCC T->A 574 S KNRLRRKSSTRHIHA 615 Phosphorylation TypeIII- BRCA1; RNF53 rs4986848 TTT->TCT F->S 947 S PPLFPIKSFVKTKCK 988 Phosphorylation: CHK2 TypeIII- BRCA1; RNF53 rs55886745 CCA->CAA P->Q 1456 S EPGVERSSPSKCPSL 1497 Phosphorylation: CDK2; CDK_group TypeIII- BRCA1; RNF53 rs56032833 GGA->CGA G->R 1289 S QMRHQSESQGVGLSD 1330 Phosphorylation TypeIII- BRCA1; RNF53 rs56032833 GGA->CGA G->R 1295 S ESQGVGLSDKELVSD 1336 Phosphorylation TypeIII- BRCA1; RNF53 rs56039126 GCG->GTG A->V 574 S KNRLRRKSSTRHIHA 615 Phosphorylation TypeIII- BRCA1; RNF53 rs56100707 CCT->CGT P->R 468 T LKRKRRPTSGLHPED 509 Phosphorylation: PKB_group TypeIII- BRCA1; RNF53 rs56100707 CCT->CGT P->R 469 S KRKRRPTSGLHPEDF 510 Phosphorylation TypeIII- BRCA1; RNF53 rs56272539 CGT->CAT R->H 468 T LKRKRRPTSGLHPED 509 Phosphorylation: PKB_group TypeIII- BRCA1; RNF53 rs56272539 CGT->CAT R->H 469 S KRKRRPTSGLHPEDF 510 Phosphorylation TypeIII- BRCA1; RNF53 rs56335406 CCA->CTA P->L 1456 S EPGVERSSPSKCPSL 1497 Phosphorylation: CDK2; CDK_group TypeIII- BRCA1; RNF53 rs56335406 CCA->CTA P->L 1458 S GVERSSPSKCPSLDD 1499 Phosphorylation TypeIII- BRCA1; RNF53 rs62625304 AAG->AGG K->R 468 T LKRKRRPTSGLHPED 509 Phosphorylation: PKB_group TypeIII- BRCA1; RNF53 rs28897691 GAT->AAT D->N 400 S EEQQLEESGPHDLTE 1542 Phosphorylation TypeIII- BRCA1; RNF53 rs55886745 CCA->CAA P->Q 355 S EPGVERSSPSKCPSL 1497 Phosphorylation: CDK2; CDK_group TypeIII- BRCA1; RNF53 rs56335406 CCA->CTA P->L 355 S EPGVERSSPSKCPSL 1497 Phosphorylation: CDK2; CDK_group TypeIII- BRCA1; RNF53 rs56335406 CCA->CTA P->L 357 S GVERSSPSKCPSLDD 1499 Phosphorylation TypeIII- BRCA1; RNF53 rs28897691 GAT->AAT D->N 438 S EEQQLEESGPHDLTE 1542 Phosphorylation TypeIII- BRCA1; RNF53 rs55886745 CCA->CAA P->Q 393 S EPGVERSSPSKCPSL 1497 Phosphorylation: CDK2; CDK_group TypeIII- BRCA1; RNF53 rs56335406 CCA->CTA P->L 393 S EPGVERSSPSKCPSL 1497 Phosphorylation: CDK2; CDK_group TypeIII- BRCA1; RNF53 rs56335406 CCA->CTA P->L 395 S GVERSSPSKCPSLDD 1499 Phosphorylation TypeIII- BRCA1; RNF53 rs28897691 GAT->AAT D->N 398 S EEQQLEESGPHDLTE 1542 Phosphorylation TypeIII- BRCA1; RNF53 rs55886745 CCA->CAA P->Q 353 S EPGVERSSPSKCPSL 1497 Phosphorylation: CDK2; CDK_group TypeIII- BRCA1; RNF53 rs56335406 CCA->CTA P->L 353 S EPGVERSSPSKCPSL 1497 Phosphorylation: CDK2; CDK_group TypeIII- BRCA1; RNF53 rs56335406 CCA->CTA P->L 355 S GVERSSPSKCPSLDD 1499 Phosphorylation TypeIII-

PTM - PhosphositePlus UniProt ID MOD_RSD Type SITE_+/-7_AA P38398 K50-ac Acetylation FCKFCMLkLLNQKKG P38398 S114-p Phosphorylation FAkKENNsPEHLkDE P38398 S123-p Phosphorylation EHLkDEVsIIQSMGY P38398 T164-p Phosphorylation SNLGTVRtLRTKQRI P38398 S184-p Phosphorylation SVYIELGsDssEDTV P38398 S186-p Phosphorylation YIELGsDssEDTVNK P38398 S187-p Phosphorylation IELGsDssEDTVNKA P38398 T208-p Phosphorylation DQELLQItPQGTRDE P38398 S220-p Phosphorylation RDEISLDsAKKAACE P38398 S308-p Phosphorylation KAEFCNKsKQPGLAR P38398 S395-p Phosphorylation RSDELLGsDDsHDGE P38398 S398-p Phosphorylation ELLGsDDsHDGEsES P38398 S403-p Phosphorylation DDsHDGEsESNAKVA P38398 S423-p Phosphorylation LNEVDEYsGssEKID P38398 S425-p Phosphorylation EVDEYsGssEKIDLL P38398 S426-p Phosphorylation VDEYsGssEKIDLLA P38398 S434-p Phosphorylation EKIDLLAsDPHEALI P38398 S451-p Phosphorylation SERVHSKsVEsNIED P38398 S454-p Phosphorylation VHSKsVEsNIEDkIF P38398 T509-p Phosphorylation LKRKRRPtsGLHPED P38398 S510-p Phosphorylation KRKRRPtsGLHPEDF P38398 S551-p Phosphorylation QVMNITNsGHENKTK P38398 S615-p Phosphorylation KNRLRRKsstRHIHA P38398 S616-p Phosphorylation NRLRRKsstRHIHAL P38398 T617-p Phosphorylation RLRRKsstRHIHALE P38398 S632-p Phosphorylation LVVSRNLsPPNCTEL P38398 S647-p Phosphorylation QIDSCSSsEEIKKKk P38398 S694-p Phosphorylation QTSKRHDsDTFPELK P38398 S708-p Phosphorylation KLTNAPGsFTKCSNT P38398 S741-p Phosphorylation kLETVkVsNNAEDPK P38398 S753-p Phosphorylation DPKDLMLsGERVLQT P38398 S803-p Phosphorylation TEPNKCVsQCAAFEN P38398 S868-p Phosphorylation FKVSKRQsFAPFSNP P38398 T967-p Phosphorylation GNETGLItPNkHGLL P38398 Y978-p Phosphorylation HGLLQNPyRIPPLFP P38398 S988-p Phosphorylation PPLFPIKsFVKTKCK P38398 S1007-p Phosphorylation EENFEEHsMsPEREM P38398 S1009-p Phosphorylation NFEEHsMsPEREMGN P38398 S1050-p Phosphorylation NINEVGSsTNEVGSS P38398 S1101-p Phosphorylation YKQSLPGsNCKHPEI P38398 S1143-p Phosphorylation PMGSSHAsQVCSETP P38398 S1164-p Phosphorylation GEIKEDTsFAENDIK P38398 S1174-p Phosphorylation ENDIKESsAVFsKSV P38398 S1178-p Phosphorylation KESsAVFsKSVQKGE P38398 S1187-p Phosphorylation SVQKGELsRsPsPFt P38398 S1189-p Phosphorylation QKGELsRsPsPFtHT P38398 S1191-p Phosphorylation GELsRsPsPFtHTHL P38398 T1194-p Phosphorylation sRsPsPFtHTHLAQG P38398 S1211-p Phosphorylation RGAKKLEssEENLss P38398 S1212-p Phosphorylation GAKKLEssEENLssE P38398 S1217-p Phosphorylation EssEENLssEDEELP P38398 S1218-p Phosphorylation ssEENLssEDEELPC P38398 S1239-p Phosphorylation GKVNNIPsQSTRHsT P38398 S1245-p Phosphorylation PsQSTRHsTVATECL P38398 S1253-p Phosphorylation TVATECLsKNTEENL P38398 S1266-p Phosphorylation NLLSLKNsLNDCsNQ P38398 S1271-p Phosphorylation KNsLNDCsNQVILAK P38398 S1280-p Phosphorylation QVILAKAsQEHHLsE P38398 S1286-p Phosphorylation AsQEHHLsEEtKCSA P38398 T1289-p Phosphorylation EHHLsEEtKCSASLF P38398 S1328-p Phosphorylation SKQMRHQsEsQGVGL P38398 S1330-p Phosphorylation QMRHQsEsQGVGLsD P38398 S1336-p Phosphorylation EsQGVGLsDKELVsD P38398 S1342-p Phosphorylation LsDKELVsDDEERGT P38398 S1387-p Phosphorylation EDCSGLSsQSDILTT P38398 S1423-p Phosphorylation AVLEQHGsQPSNSYP P38398 S1457-p Phosphorylation SEKAVLTsQKsSEYP P38398 S1460-p Phosphorylation AVLTsQKsSEYPIsQ P38398 S1466-p Phosphorylation KsSEYPIsQNPEGLs P38398 S1473-p Phosphorylation sQNPEGLsADKFEVs P38398 S1480-p Phosphorylation sADKFEVsADsSTSK P38398 S1483-p Phosphorylation KFEVsADsSTSKNKE P38398 S1496-p Phosphorylation KEPGVERssPsKCPs P38398 S1497-p Phosphorylation EPGVERssPsKCPsL P38398 S1499-p Phosphorylation GVERssPsKCPsLDD P38398 S1503-p Phosphorylation ssPsKCPsLDDRWYM P38398 S1514-p Phosphorylation RWYMHSCsGSLQNRN P38398 S1524-p Phosphorylation LQNRNYPsQEELIKV P38398 S1542-p Phosphorylation EEQQLEEsGPHDLtE P38398 T1548-p Phosphorylation EsGPHDLtEtSyLPR P38398 T1550-p Phosphorylation GPHDLtEtSyLPRQD P38398 Y1552-p Phosphorylation HDLtEtSyLPRQDLE P38398 S1572-p Phosphorylation ESGISLFsDDPEsDP P38398 S1577-p Phosphorylation LFsDDPEsDPSEDRA P38398 S1613-p Phosphorylation KVAESAQsPAAAHtT P38398 T1619-p Phosphorylation QsPAAAHtTDTAGYN P38398 S1642-p Phosphorylation EKPELTAsTERVNKR P38398 T1681-p Phosphorylation ITLTNLItEETTHVV P38398 T1700-p Phosphorylation AEFVCERtLKYFLGI P38398 T1720-p Phosphorylation VVSYFWVtQSIKERK P38398 T1777-p Phosphorylation GPFTNMPtDQLEWMV P38398 S1790-p Phosphorylation MVQLCGAsVVKELSS P38398 K109-sm Sumoylation ANSYNFAkKENNsPE P38398 K119-sm Sumoylation NNsPEHLkDEVsIIQ P38398 K339-sm Sumoylation RTPSTEKkVDLNADP P38398 K443-sm Sumoylation PHEALICkSERVHSK P38398 K459-sm Sumoylation VEsNIEDkIFGKTYR P38398 K583-sm Sumoylation KESAFKTkAEPISSS P38398 K654-sm Sumoylation sEEIKKKkYNQMPVR P38398 K734-sm Sumoylation PREEKEEkLETVkVs P38398 K739-sm Sumoylation EEkLETVkVsNNAED P38398 K918-sm Sumoylation GKNESNIkPVQTVNI P38398 K1079-sm Sumoylation LGRNRGPkLNAMLRL P38398 K970-ub Ubiquitination TGLItPNkHGLLQNP P38398 K1667-ub Ubiquitination EEFMLVYkFARKHHI

PTM - dbPTM UniProt ID Position Code Type Resources References P38398 308 S Phosphorylation Swiss-Prot 1010711 14990569 P38398 395 S Phosphorylation Swiss-Prot 1010711 18669648;19690332 P38398 398 S Phosphorylation Swiss-Prot 1010711 18669648;19690332 P38398 403 S Phosphorylation Swiss-Prot 1010711 18669648 P38398 753 S Phosphorylation Swiss-Prot 1010711 18669648 P38398 988 S Phosphorylation Swiss-Prot 1010711 10724175;20364141 P38398 1143 S Phosphorylation Swiss-Prot 1010711 11114888 P38398 1211 S Phosphorylation Swiss-Prot 1010711 17081983;18669648 P38398 1212 S Phosphorylation Swiss-Prot 1010711 17081983 P38398 1217 S Phosphorylation Swiss-Prot 1010711 17081983;18669648 P38398 1218 S Phosphorylation Swiss-Prot 1010711 17081983;18669648 P38398 1239 S Phosphorylation Swiss-Prot 1010711 17525332 P38398 1245 S Phosphorylation Swiss-Prot 1010711 17525332 P38398 1280 S Phosphorylation Swiss-Prot 1010711 11114888 P38398 1330 S Phosphorylation Swiss-Prot 1010711 17525332 P38398 1336 S Phosphorylation Swiss-Prot 1010711 17081983;17525332 P38398 1342 S Phosphorylation Swiss-Prot 1010711 17525332 P38398 1387 S Phosphorylation Swiss-Prot 1010711 11114888 P38398 1394 T Phosphorylation Swiss-Prot 1010711 11114888 P38398 1423 S Phosphorylation Swiss-Prot 1010711 11114888 P38398 1457 S Phosphorylation Swiss-Prot 1010711 11114888;17525332 P38398 1466 S Phosphorylation Swiss-Prot 1010711 17525332 P38398 1524 S Phosphorylation Swiss-Prot 1010711 17525332 P38398 1542 S Phosphorylation Swiss-Prot 1010711 18220336 P38398 1700 T Phosphorylation Swiss-Prot 1010711 17525332 P38398 1720 T Phosphorylation Swiss-Prot 1010711 17525332 P38398 395 S Phosphorylation PhosphoELM.10011 18669648 P38398 398 S Phosphorylation PhosphoELM.10011 18669648 P38398 403 S Phosphorylation PhosphoELM.10011 18669648 P38398 405 S Phosphorylation PhosphoELM.10011 18669648 P38398 753 S Phosphorylation PhosphoELM.10011 18669648 P38398 1189 S Phosphorylation PhosphoELM.10011 10550055 P38398 1211 S Phosphorylation PhosphoELM.10011 18669648 P38398 1212 S Phosphorylation PhosphoELM.10011 18669648 P38398 1217 S Phosphorylation PhosphoELM.10011 18669648 P38398 1218 S Phosphorylation PhosphoELM.10011 18669648 P38398 1239 S Phosphorylation PhosphoELM.10011 17525332 P38398 1245 S Phosphorylation PhosphoELM.10011 17525332 P38398 1336 S Phosphorylation PhosphoELM.10011 17525332;17081983 P38398 1342 S Phosphorylation PhosphoELM.10011 17525332 P38398 1499 S Phosphorylation PhosphoELM.10011 17081983 P38398 1542 S Phosphorylation PhosphoELM.10011 18220336;10550055 P38398 1330 S Phosphorylation PhosphoELM.10011 17525332;10550055 P38398 1387 S Phosphorylation PhosphoELM.10011 12183412 P38398 1466 S Phosphorylation PhosphoELM.10011 17525332;10550055 P38398 1457 S Phosphorylation PhosphoELM.10011 17525332;11278964;10550055;11278964 P38398 1524 S Phosphorylation PhosphoELM.10011 17525332;11278964;10550055;11278964 P38398 1423 S Phosphorylation PhosphoELM.10011 11278964;10550055;11114888;11278964 P38398 308 S Phosphorylation PhosphoELM.10011 14990569 P38398 1497 S Phosphorylation PhosphoELM.10011 10373534;10550055 P38398 988 S Phosphorylation PhosphoELM.10011 14701743;12111733 P38398 1700 T Phosphorylation PhosphoELM.10011 17525332 P38398 1720 T Phosphorylation PhosphoELM.10011 17525332 P38398 509 T Phosphorylation PhosphoELM.10011 10542266 P38398 119 K Sumoylation Phosphositeplus.1010730 20016594 P38398 1667 K Ubiquitylation Phosphositeplus.1010730 21906983 P38398 114 S Phosphorylation Phosphositeplus.1010730 20068231;20363803;21406692;22115753 P38398 1143 S Phosphorylation Phosphositeplus.1010730 17531442 P38398 1187 S Phosphorylation Phosphositeplus.1010730 20068231;20363803;22115753 P38398 1189 S Phosphorylation Phosphositeplus.1010730 10550055;19683496;20068231;20363803;21406692;21706030;22115753 P38398 1191 S Phosphorylation Phosphositeplus.1010730 19683496;20363803;21406692;21706030;22115753 P38398 1211 S Phosphorylation Phosphositeplus.1010730 17081983;18669648;19276368;20068231 P38398 1212 S Phosphorylation Phosphositeplus.1010730 17081983;19276368;20068231 P38398 1217 S Phosphorylation Phosphositeplus.1010730 17081983;18669648;19276368;20068231;20363803;21406692;22115753 P38398 1218 S Phosphorylation Phosphositeplus.1010730 17081983;18669648;19276368;20068231;20363803;21406692;22115753 P38398 1239 S Phosphorylation Phosphositeplus.1010730 17525332 P38398 1245 S Phosphorylation Phosphositeplus.1010730 17525332 P38398 1280 S Phosphorylation Phosphositeplus.1010730 17531442;20363803 P38398 1286 S Phosphorylation Phosphositeplus.1010730 20068231 P38398 1328 S Phosphorylation Phosphositeplus.1010730 20068231;20164059 P38398 1330 S Phosphorylation Phosphositeplus.1010730 17525332 P38398 1336 S Phosphorylation Phosphositeplus.1010730 17525332;20068231;20164059;20363803;21406692;22115753 P38398 1342 S Phosphorylation Phosphositeplus.1010730 17525332;20068231;21406692 P38398 1387 S Phosphorylation Phosphositeplus.1010730 10608806;10866324;11278964;12183412;19268590;19622773 P38398 1423 S Phosphorylation Phosphositeplus.1010730 10550055;10866324;11114888;11278964;11313470;12183412;12427729;15159397;17015476;19268590;19622773 P38398 1457 S Phosphorylation Phosphositeplus.1010730 10550055;10866324;11278964;17525332;19622773 P38398 1466 S Phosphorylation Phosphositeplus.1010730 17525332 P38398 1483 S Phosphorylation Phosphositeplus.1010730 20363803 P38398 1497 S Phosphorylation Phosphositeplus.1010730 10373534;10550055;12427729;19683496;21706030 P38398 1524 S Phosphorylation Phosphositeplus.1010730 10550055;11278964;12183412;12427729;15096610;15159397;17525332;19268590;19574224;19622773;20068231;20363803;22115753 P38398 1542 S Phosphorylation Phosphositeplus.1010730 10550055;18220336;22115753 P38398 1572 S Phosphorylation Phosphositeplus.1010730 10403822 P38398 1577 S Phosphorylation Phosphositeplus.1010730 20068231;22115753 P38398 308 S Phosphorylation Phosphositeplus.1010730 14990569 P38398 395 S Phosphorylation Phosphositeplus.1010730 18669648;19690332;20363803;21406692;22115753 P38398 398 S Phosphorylation Phosphositeplus.1010730 18669648;19690332;21406692 P38398 423 S Phosphorylation Phosphositeplus.1010730 20068231;22115753 P38398 425 S Phosphorylation Phosphositeplus.1010730 22115753 P38398 426 S Phosphorylation Phosphositeplus.1010730 22115753 P38398 434 S Phosphorylation Phosphositeplus.1010730 20068231 P38398 451 S Phosphorylation Phosphositeplus.1010730 20164059 P38398 454 S Phosphorylation Phosphositeplus.1010730 20164059 P38398 510 S Phosphorylation Phosphositeplus.1010730 20736484 P38398 615 S Phosphorylation Phosphositeplus.1010730 20736484 P38398 616 S Phosphorylation Phosphositeplus.1010730 20736484 P38398 632 S Phosphorylation Phosphositeplus.1010730 17334399 P38398 694 S Phosphorylation Phosphositeplus.1010730 20068231;20085797 P38398 753 S Phosphorylation Phosphositeplus.1010730 18669648;20068231;20363803 P38398 988 S Phosphorylation Phosphositeplus.1010730 10724175;12427729;14701743;18987440 P38398 1550 T Phosphorylation Phosphositeplus.1010730 19276368 P38398 1700 T Phosphorylation Phosphositeplus.1010730 17525332 P38398 1720 T Phosphorylation Phosphositeplus.1010730 17525332 P38398 509 T Phosphorylation Phosphositeplus.1010730 10542266;17428466;20085797;20736484 P38398 617 T Phosphorylation Phosphositeplus.1010730 20736484 P38398 909 N N-linked Glycosylation HPRD 9.0 19522481 P38398 913 N N-linked Glycosylation HPRD 9.0 19522481 P38398 916 N N-linked Glycosylation HPRD 9.0 19522481 P38398 1 M Methylation HPRD 9.0 555 P38398 114 S Phosphorylation HPRD 9.0 18452278,20068231 P38398 316 S Phosphorylation HPRD 9.0 19651622,20068231 P38398 324 S Phosphorylation HPRD 9.0 17525332 P38398 387 S Phosphorylation HPRD 9.0 20068231 P38398 395 S Phosphorylation HPRD 9.0 17081983 P38398 395 S Phosphorylation HPRD 9.0 18669648 P38398 398 S Phosphorylation HPRD 9.0 18669648,18452278 P38398 403 S Phosphorylation HPRD 9.0 18669648,18452278 P38398 405 S Phosphorylation HPRD 9.0 18669648 P38398 423 S Phosphorylation HPRD 9.0 18452278,20068231 P38398 426 S Phosphorylation HPRD 9.0 18452278,20068231 P38398 434 S Phosphorylation HPRD 9.0 20068231 P38398 647 S Phosphorylation HPRD 9.0 18452278,20068231 P38398 694 S Phosphorylation HPRD 9.0 18452278,20068231 P38398 753 S Phosphorylation HPRD 9.0 18669648,20068231 P38398 1007 S Phosphorylation HPRD 9.0 18452278,20068231 P38398 1009 S Phosphorylation HPRD 9.0 18452278 P38398 1140 S Phosphorylation HPRD 9.0 19651622,20068231 P38398 1164 S Phosphorylation HPRD 9.0 17081983,18669648,20068231 P38398 1164 S Phosphorylation HPRD 9.0 20068231 P38398 1187 S Phosphorylation HPRD 9.0 19651622,20068231 P38398 1189 S Phosphorylation HPRD 9.0 19651622,20068231 P38398 1191 S Phosphorylation HPRD 9.0 19651622,20068231 P38398 1211 S Phosphorylation HPRD 9.0 17081983,18669648,20068231 P38398 1212 S Phosphorylation HPRD 9.0 17081983,18669648,20068231 P38398 1217 S Phosphorylation HPRD 9.0 17081983,18669648,20068231 P38398 1218 S Phosphorylation HPRD 9.0 17081983,18669648,20068231 P38398 1239 S Phosphorylation HPRD 9.0 17525332 P38398 1239 S Phosphorylation HPRD 9.0 20068231 P38398 1245 S Phosphorylation HPRD 9.0 17525332 P38398 1245 S Phosphorylation HPRD 9.0 20068231 P38398 1286 S Phosphorylation HPRD 9.0 20068231 P38398 1301 S Phosphorylation HPRD 9.0 17525332,18452278,20068231 P38398 1328 S Phosphorylation HPRD 9.0 19651622,18452278,20068231 P38398 1330 S Phosphorylation HPRD 9.0 17525332 P38398 1336 S Phosphorylation HPRD 9.0 17525332,19651622,18452278,20068231 P38398 1342 S Phosphorylation HPRD 9.0 17525332,18452278,20068231 P38398 1457 S Phosphorylation HPRD 9.0 17525332 P38398 1460 S Phosphorylation HPRD 9.0 19651622,20068231 P38398 1466 S Phosphorylation HPRD 9.0 17525332 P38398 1497 S Phosphorylation HPRD 9.0 17081983 P38398 1499 S Phosphorylation HPRD 9.0 17081983 P38398 1542 S Phosphorylation HPRD 9.0 20068231 P38398 1577 S Phosphorylation HPRD 9.0 20068231 P38398 1598 S Phosphorylation HPRD 9.0 20068231 P38398 1149 T Phosphorylation HPRD 9.0 20068231 P38398 1196 T Phosphorylation HPRD 9.0 20068231 P38398 1700 T Phosphorylation HPRD 9.0 17525332 P38398 1720 T Phosphorylation HPRD 9.0 17525332 P38398 1202 Y Phosphorylation HPRD 9.0 20068231 P38398 509 T Phosphorylation (AKT1) HPRD 9.0 10542266 P38398 281 S Phosphorylation (ATM) HPRD 9.0 10550055 P38398 398 S Phosphorylation (ATM) HPRD 9.0 10550055,20068231 P38398 1189 S Phosphorylation (ATM) HPRD 9.0 10550055,19651622,20068231 P38398 1330 S Phosphorylation (ATM) HPRD 9.0 10550055 P38398 1387 S Phosphorylation (ATM) HPRD 9.0 11278964 P38398 1423 S Phosphorylation (ATM) HPRD 9.0 10550055,10866324,11278964,15159397 P38398 1423 S Phosphorylation (ATM) HPRD 9.0 10550055,15159397 P38398 1457 S Phosphorylation (ATM) HPRD 9.0 10550055,10866324,11278964 P38398 1466 S Phosphorylation (ATM) HPRD 9.0 10550055 P38398 1483 S Phosphorylation (ATM) HPRD 9.0 10550055,20068231 P38398 1524 S Phosphorylation (ATM) HPRD 9.0 11278964,20068231 P38398 1542 S Phosphorylation (ATM) HPRD 9.0 10550055,20068231 P38398 281 S Phosphorylation (ATR) HPRD 9.0 11114888 P38398 1143 S Phosphorylation (ATR) HPRD 9.0 11114888 P38398 1239 S Phosphorylation (ATR) HPRD 9.0 11114888 P38398 1280 S Phosphorylation (ATR) HPRD 9.0 11114888 P38398 1387 S Phosphorylation (ATR) HPRD 9.0 11114888 P38398 1423 S Phosphorylation (ATR) HPRD 9.0 11114888,11278964,15159397 P38398 1423 S Phosphorylation (ATR) HPRD 9.0 11114888,15159397 P38398 1457 S Phosphorylation (ATR) HPRD 9.0 11114888,11278964 P38398 1524 S Phosphorylation (ATR) HPRD 9.0 11278964,20068231 P38398 1394 T Phosphorylation (ATR) HPRD 9.0 11114888 P38398 308 S Phosphorylation (AURKA) HPRD 9.0 14990569 P38398 1450 S Phosphorylation (CDK2) HPRD 9.0 10373534 P38398 1497 S Phosphorylation (CDK2) HPRD 9.0 10373534 P38398 967 T Phosphorylation (CDK2) HPRD 9.0 10373534 P38398 988 S Phosphorylation (CHEK2) HPRD 9.0 10724175,12111733 P38398 988 S Phosphorylation (CHEK2) HPRD 9.0 10724175 P38398 1572 S Phosphorylation (CSNK2A1) HPRD 9.0 10403822 P38398 1155 D Proteolytic Cleavage HPRD 9.0 12149654 P38398 395 S Phosphorylation SysPTM 1.1 18669648 P38398 398 S Phosphorylation SysPTM 1.1 18669648 P38398 403 S Phosphorylation SysPTM 1.1 18669648 P38398 753 S Phosphorylation SysPTM 1.1 18669648 P38398 1211 S Phosphorylation SysPTM 1.1 17081983;18669648 P38398 1212 S Phosphorylation SysPTM 1.1 17081983 P38398 1217 S Phosphorylation SysPTM 1.1 17081983;18669648 P38398 1218 S Phosphorylation SysPTM 1.1 17081983;18669648 P38398 1336 S Phosphorylation SysPTM 1.1 17081983

PTM - HPRD Symbol Position Code Type References BRCA1 1 M Methylation 555 BRCA1 1007 S Phosphorylation 18452278,20068231 BRCA1 1009 S Phosphorylation 18452278 BRCA1 1096 S Phosphorylation 11114888 BRCA1 1102 S Phosphorylation 11114888 BRCA1 1108 D Proteolytic Cleavage 12149654 BRCA1 1114 D Proteolytic Cleavage 12149654 BRCA1 1117 S Phosphorylation 20068231 BRCA1 1123 S Phosphorylation 20068231 BRCA1 114 S Phosphorylation 18452278,20068231 BRCA1 1140 S Phosphorylation 19651622,20068231 BRCA1 1142 S Phosphorylation 10550055,19651622,20068231 BRCA1 1143 S Phosphorylation 11114888 BRCA1 1144 S Phosphorylation 19651622,20068231 BRCA1 1146 S Phosphorylation 19651622,20068231 BRCA1 1148 S Phosphorylation 10550055,19651622,20068231 BRCA1 1149 T Phosphorylation 20068231 BRCA1 1150 S Phosphorylation 19651622,20068231 BRCA1 1155 D Proteolytic Cleavage 12149654 BRCA1 1155 T Phosphorylation 20068231 BRCA1 1155 Y Phosphorylation 20068231 BRCA1 1161 Y Phosphorylation 20068231 BRCA1 1164 S Phosphorylation 17081983,18669648,20068231 BRCA1 1164 S Phosphorylation 20068231 BRCA1 1165 S Phosphorylation 17081983,18669648,20068231 BRCA1 1170 S Phosphorylation 17081983,18669648,20068231 BRCA1 1171 S Phosphorylation 17081983,18669648,20068231 BRCA1 1176 S Phosphorylation 17081983,18669648,20068231 BRCA1 1177 S Phosphorylation 17081983,18669648,20068231 BRCA1 1187 S Phosphorylation 19651622,20068231 BRCA1 1189 S Phosphorylation 10550055,19651622,20068231 BRCA1 1189 S Phosphorylation 19651622,20068231 BRCA1 1191 S Phosphorylation 19651622,20068231 BRCA1 1192 S Phosphorylation 17525332 BRCA1 1196 T Phosphorylation 20068231 BRCA1 1198 S Phosphorylation 17525332 BRCA1 1202 Y Phosphorylation 20068231 BRCA1 1204 S Phosphorylation 17525332 BRCA1 1211 S Phosphorylation 17081983,18669648,20068231 BRCA1 1212 S Phosphorylation 17081983,18669648,20068231 BRCA1 1217 S Phosphorylation 17081983,18669648,20068231 BRCA1 1218 S Phosphorylation 17081983,18669648,20068231 BRCA1 1233 S Phosphorylation 11114888 BRCA1 1239 S Phosphorylation 11114888 BRCA1 1239 S Phosphorylation 17525332 BRCA1 1239 S Phosphorylation 20068231 BRCA1 1245 S Phosphorylation 17525332 BRCA1 1245 S Phosphorylation 20068231 BRCA1 1280 S Phosphorylation 11114888 BRCA1 1281 S Phosphorylation 19651622,18452278,20068231 BRCA1 1283 S Phosphorylation 10550055 BRCA1 1286 S Phosphorylation 20068231 BRCA1 1287 S Phosphorylation 19651622,18452278,20068231 BRCA1 1289 S Phosphorylation 10550055 BRCA1 1289 S Phosphorylation 17525332,19651622,18452278,20068231 BRCA1 1295 S Phosphorylation 17525332,18452278,20068231 BRCA1 1295 S Phosphorylation 17525332,19651622,18452278,20068231 BRCA1 1301 S Phosphorylation 17525332,18452278,20068231 BRCA1 1328 S Phosphorylation 19651622,18452278,20068231 BRCA1 1330 S Phosphorylation 10550055 BRCA1 1330 S Phosphorylation 17525332 BRCA1 1336 S Phosphorylation 17525332,19651622,18452278,20068231 BRCA1 1340 S Phosphorylation 11278964 BRCA1 1342 S Phosphorylation 17525332,18452278,20068231 BRCA1 1346 S Phosphorylation 11278964 BRCA1 1347 T Phosphorylation 11114888 BRCA1 1353 T Phosphorylation 11114888 BRCA1 1376 S Phosphorylation 10550055 BRCA1 1376 S Phosphorylation 11114888 BRCA1 1382 S Phosphorylation 10550055 BRCA1 1382 S Phosphorylation 11114888 BRCA1 1387 S Phosphorylation 11114888 BRCA1 1387 S Phosphorylation 11278964 BRCA1 1394 T Phosphorylation 11114888 BRCA1 1410 S Phosphorylation 10550055 BRCA1 1410 S Phosphorylation 11114888 BRCA1 1413 S Phosphorylation 19651622,20068231 BRCA1 1416 S Phosphorylation 10550055 BRCA1 1416 S Phosphorylation 11114888 BRCA1 1419 S Phosphorylation 17525332 BRCA1 1419 S Phosphorylation 19651622,20068231 BRCA1 1423 S Phosphorylation 10550055,10866324,11278964,15159397 BRCA1 1423 S Phosphorylation 10550055,15159397 BRCA1 1423 S Phosphorylation 11114888,11278964,15159397 BRCA1 1423 S Phosphorylation 11114888,15159397 BRCA1 1425 S Phosphorylation 17525332 BRCA1 1450 S Phosphorylation 10373534 BRCA1 1452 S Phosphorylation 17081983 BRCA1 1456 S Phosphorylation 10373534 BRCA1 1457 S Phosphorylation 10550055,10866324,11278964 BRCA1 1457 S Phosphorylation 11114888,11278964 BRCA1 1457 S Phosphorylation 17525332 BRCA1 1458 S Phosphorylation 17081983 BRCA1 1460 S Phosphorylation 19651622,20068231 BRCA1 1466 S Phosphorylation 10550055 BRCA1 1466 S Phosphorylation 17525332 BRCA1 1477 S Phosphorylation 10550055,20068231 BRCA1 1481 S Phosphorylation 19651622,20068231 BRCA1 1483 S Phosphorylation 10550055,20068231 BRCA1 1495 S Phosphorylation 10550055,20068231 BRCA1 1497 S Phosphorylation 10373534 BRCA1 1497 S Phosphorylation 17081983 BRCA1 1499 S Phosphorylation 17081983 BRCA1 1501 S Phosphorylation 10550055,20068231 BRCA1 1524 S Phosphorylation 11278964,20068231 BRCA1 1525 S Phosphorylation 10403822 BRCA1 1530 S Phosphorylation 20068231 BRCA1 1531 S Phosphorylation 10403822 BRCA1 1536 S Phosphorylation 20068231 BRCA1 1542 S Phosphorylation 10550055,20068231 BRCA1 1542 S Phosphorylation 20068231 BRCA1 1545 S Phosphorylation 20068231 BRCA1 1563 S Phosphorylation 20068231 BRCA1 1572 S Phosphorylation 10403822 BRCA1 1577 S Phosphorylation 20068231 BRCA1 1598 S Phosphorylation 20068231 BRCA1 1653 T Phosphorylation 17525332 BRCA1 1659 T Phosphorylation 17525332 BRCA1 1673 T Phosphorylation 17525332 BRCA1 1679 T Phosphorylation 17525332 BRCA1 1700 T Phosphorylation 17525332 BRCA1 1720 T Phosphorylation 17525332 BRCA1 243 S Phosphorylation 11278964 BRCA1 245 S Phosphorylation 11278964 BRCA1 250 T Phosphorylation 11114888 BRCA1 252 T Phosphorylation 11114888 BRCA1 279 S Phosphorylation 10550055 BRCA1 279 S Phosphorylation 11114888 BRCA1 281 S Phosphorylation 10550055 BRCA1 281 S Phosphorylation 11114888 BRCA1 284 S Phosphorylation 11278964 BRCA1 291 T Phosphorylation 11114888 BRCA1 308 S Phosphorylation 14990569 BRCA1 313 S Phosphorylation 10550055 BRCA1 313 S Phosphorylation 11114888 BRCA1 315 S Phosphorylation 10550055 BRCA1 315 S Phosphorylation 11114888 BRCA1 316 S Phosphorylation 19651622,20068231 BRCA1 318 S Phosphorylation 19651622,20068231 BRCA1 320 S Phosphorylation 10550055 BRCA1 320 S Phosphorylation 10550055,15159397 BRCA1 320 S Phosphorylation 11114888 BRCA1 320 S Phosphorylation 11114888,15159397 BRCA1 322 S Phosphorylation 17525332 BRCA1 324 S Phosphorylation 17525332 BRCA1 348 S Phosphorylation 18669648 BRCA1 351 S Phosphorylation 18669648,18452278 BRCA1 353 S Phosphorylation 10373534 BRCA1 353 S Phosphorylation 10550055 BRCA1 353 S Phosphorylation 11114888 BRCA1 354 S Phosphorylation 18669648 BRCA1 355 S Phosphorylation 10373534 BRCA1 355 S Phosphorylation 17081983 BRCA1 356 S Phosphorylation 18669648,18452278 BRCA1 356 S Phosphorylation 19651622,20068231 BRCA1 357 S Phosphorylation 17081983 BRCA1 357 S Phosphorylation 18669648,18452278 BRCA1 358 S Phosphorylation 18669648 BRCA1 362 S Phosphorylation 17525332 BRCA1 362 S Phosphorylation 18669648,18452278 BRCA1 364 S Phosphorylation 18669648 BRCA1 376 S Phosphorylation 18452278,20068231 BRCA1 379 S Phosphorylation 18452278,20068231 BRCA1 380 S Phosphorylation 10550055,20068231 BRCA1 382 S Phosphorylation 10550055,20068231 BRCA1 382 S Phosphorylation 18452278,20068231 BRCA1 385 S Phosphorylation 18452278,20068231 BRCA1 387 S Phosphorylation 20068231 BRCA1 393 S Phosphorylation 10373534 BRCA1 393 S Phosphorylation 20068231 BRCA1 395 S Phosphorylation 17081983 BRCA1 395 S Phosphorylation 18669648 BRCA1 398 S Phosphorylation 10550055,20068231 BRCA1 398 S Phosphorylation 18669648,18452278 BRCA1 400 S Phosphorylation 10550055,20068231 BRCA1 403 S Phosphorylation 18669648,18452278 BRCA1 405 S Phosphorylation 18669648 BRCA1 420 S Phosphorylation 10550055,20068231 BRCA1 420 S Phosphorylation 20068231 BRCA1 423 S Phosphorylation 18452278,20068231 BRCA1 426 S Phosphorylation 18452278,20068231 BRCA1 428 S Phosphorylation 10403822 BRCA1 430 S Phosphorylation 10403822 BRCA1 433 S Phosphorylation 20068231 BRCA1 434 S Phosphorylation 20068231 BRCA1 435 S Phosphorylation 20068231 BRCA1 438 S Phosphorylation 10550055,20068231 BRCA1 438 S Phosphorylation 20068231 BRCA1 462 T Phosphorylation 10542266 BRCA1 468 S Phosphorylation 10403822 BRCA1 468 T Phosphorylation 10542266 BRCA1 473 S Phosphorylation 20068231 BRCA1 509 T Phosphorylation 10542266 BRCA1 556 T Phosphorylation 17525332 BRCA1 558 T Phosphorylation 17525332 BRCA1 576 T Phosphorylation 17525332 BRCA1 578 T Phosphorylation 17525332 BRCA1 596 T Phosphorylation 17525332 BRCA1 616 T Phosphorylation 17525332 BRCA1 647 S Phosphorylation 18452278,20068231 BRCA1 653 S Phosphorylation 18452278,20068231 BRCA1 67 S Phosphorylation 18452278,20068231 BRCA1 694 S Phosphorylation 18452278,20068231 BRCA1 706 S Phosphorylation 18669648,20068231 BRCA1 712 S Phosphorylation 18669648,20068231 BRCA1 753 S Phosphorylation 18669648,20068231 BRCA1 862 N Glycosylation 19522481 BRCA1 866 N Glycosylation 19522481 BRCA1 868 N Glycosylation 19522481 BRCA1 869 N Glycosylation 19522481 BRCA1 872 N Glycosylation 19522481 BRCA1 875 N Glycosylation 19522481 BRCA1 909 N Glycosylation 19522481 BRCA1 913 N Glycosylation 19522481 BRCA1 916 N Glycosylation 19522481 BRCA1 941 S Phosphorylation 10724175 BRCA1 947 S Phosphorylation 10724175 BRCA1 960 S Phosphorylation 18452278,20068231 BRCA1 962 S Phosphorylation 18452278 BRCA1 966 S Phosphorylation 18452278,20068231 BRCA1 967 T Phosphorylation 10373534 BRCA1 968 S Phosphorylation 18452278 BRCA1 988 S Phosphorylation 10724175 BRCA1 988 S Phosphorylation 10724175,12111733

PTM - Phospho.ELM UniProt Position Code PMIDs Kinase Source Type P38398 1542 S 18220336 HTP Phosphorylation P38398 1542 S 10550055 LTP Phosphorylation P38398 1423 S 11278964 ATM LTP Phosphorylation P38398 1423 S 10550055 ATM LTP Phosphorylation P38398 1423 S 11114888 ATR LTP Phosphorylation P38398 1423 S 11278964 ATR LTP Phosphorylation P38398 395 S 18669648 HTP Phosphorylation P38398 1700 T 17525332 HTP Phosphorylation P38398 398 S 18669648 HTP Phosphorylation P38398 1720 T 17525332 HTP Phosphorylation P38398 403 S 18669648 HTP Phosphorylation P38398 405 S 18669648 HTP Phosphorylation P38398 1189 S 10550055 LTP Phosphorylation P38398 1457 S 17525332 HTP Phosphorylation P38398 1457 S 11278964 ATM LTP Phosphorylation P38398 1457 S 10550055 ATM LTP Phosphorylation P38398 1457 S 11278964 ATR LTP Phosphorylation P38398 1330 S 17525332 HTP Phosphorylation P38398 1330 S 10550055 ATM LTP Phosphorylation P38398 308 S 14990569 Aurora A LTP Phosphorylation P38398 1466 S 17525332 HTP Phosphorylation P38398 1466 S 10550055 ATM LTP Phosphorylation P38398 1211 S 18669648 HTP Phosphorylation P38398 1212 S 18669648 HTP Phosphorylation P38398 1342 S 17525332 HTP Phosphorylation P38398 1217 S 18669648 HTP Phosphorylation P38398 1218 S 18669648 HTP Phosphorylation P38398 1336 S 17525332 HTP Phosphorylation P38398 1336 S 17081983 HTP Phosphorylation P38398 1239 S 17525332 HTP Phosphorylation P38398 1497 S 10373534 CDK2 LTP Phosphorylation P38398 1497 S 10550055 ATM LTP Phosphorylation P38398 1499 S 17081983 HTP Phosphorylation P38398 988 S 14701743 CHK2 LTP Phosphorylation P38398 988 S 12111733 CHK2 LTP Phosphorylation P38398 1245 S 17525332 HTP Phosphorylation P38398 1387 S 12183412 ATM LTP Phosphorylation P38398 753 S 18669648 HTP Phosphorylation P38398 1524 S 17525332 HTP Phosphorylation P38398 1524 S 11278964 ATM LTP Phosphorylation P38398 1524 S 10550055 ATM LTP Phosphorylation P38398 1524 S 11278964 ATR LTP Phosphorylation P38398 509 T 10542266 PKB_group LTP Phosphorylation

PTM - UniProt UniProt ID Position Type PMIDs P38398 1 N-acetylmethionine 22814378 P38398 114 Phosphoserine 20068231;21406692;23186163 P38398 308 Phosphoserine; by AURKA 14990569 P38398 395 Phosphoserine 18669648;19690332 P38398 398 Phosphoserine 18669648;19690332 P38398 423 Phosphoserine 20068231 P38398 434 Phosphoserine 23186163 P38398 551 Phosphoserine 23186163 P38398 694 Phosphoserine 20068231;23186163 P38398 708 Phosphoserine 23186163 P38398 753 Phosphoserine 18669648 P38398 988 Phosphoserine; by CHEK2 10724175;20364141 P38398 1009 Phosphoserine 23186163 P38398 1143 Phosphoserine; by ATR; in vitro 11114888 P38398 1189 Phosphoserine 23186163 P38398 1191 Phosphoserine 23186163 P38398 1211 Phosphoserine 18669648 P38398 1217 Phosphoserine 18669648 P38398 1218 Phosphoserine 18669648;21406692 P38398 1280 Phosphoserine; by ATR; in vitro 11114888 P38398 1328 Phosphoserine 20068231 P38398 1336 Phosphoserine 17081983;20068231;21406692 P38398 1342 Phosphoserine 20068231;21406692 P38398 1387 Phosphoserine; by ATM and ATR 11114888 P38398 1394 Phosphothreonine; by ATR; in vitro 11114888 P38398 1423 Phosphoserine; by ATM and ATR 11114888 P38398 1457 Phosphoserine; by ATR; in vitro 11114888 P38398 1524 Phosphoserine; by ATM 21144835 P38398 1542 Phosphoserine 23186163

PTM - PHOSIDA Symbol Accession Code Position Surrounding Sequence Type BRCA1 IPI00218982 S 1007 ENFEEHpSMSPERE phosphorylation BRCA1 IPI00218982 S 1009 FEEHSMpSPEREMG phosphorylation BRCA1 IPI00218982 S 114 AKKENNpSPEHLKD phosphorylation BRCA1 IPI00218982 S 1187 VQKGELpSRSPSPF phosphorylation BRCA1 IPI00218982 S 1189 KGELSRpSPSPFTH phosphorylation BRCA1 IPI00218982 S 1191 ELSRSPpSPFTHTH phosphorylation BRCA1 IPI00218982 S 1211 GAKKLEpSSEENLS phosphorylation BRCA1 IPI00218982 S 1212 AKKLESpSEENLSS phosphorylation BRCA1 IPI00218982 S 1217 SSEENLpSSEDEEL phosphorylation BRCA1 IPI00218982 S 1218 SEENLSpSEDEELP phosphorylation BRCA1 IPI00218982 S 1286 SQEHHLpSEETKCS phosphorylation BRCA1 IPI00218982 S 1328 KQMRHQpSESQGVG phosphorylation BRCA1 IPI00218982 S 1336 SQGVGLpSDKELVS phosphorylation BRCA1 IPI00218982 S 1499 VERSSPpSKCPSLD phosphorylation BRCA1 IPI00218982 S 1524 QNRNYPpSQEELIK phosphorylation BRCA1 IPI00218982 S 694 TSKRHDpSDTFPEL phosphorylation BRCA1 IPI00218982 S 753 PKDLMLpSGERVLQ phosphorylation BRCA1 IPI00218982 T 1196 PSPFTHpTHLAQGY phosphorylation

PTM - BioGRID Entrez Gene BioGRID ID Position Code Type PMIDs 672 107140 - K Sumoylation 20016594 672 107140 - K Ubiquitination 15665273 672 107140 - K Ubiquitination 19887602 672 107140 - K Ubiquitination 20631078 672 107140 - K Ubiquitination 20351172 672 107140 - K Sumoylation 21147198 672 107140 - K Sumoylation 21693764 672 107140 - K Ubiquitination 21890473 672 107140 - K Ubiquitination 21906983 672 107140 - K Ubiquitination 19074549 672 107140 - K Ubiquitination 18593910 672 107140 - K Ubiquitination 23086937 672 107140 - K Ubiquitination 24342616 672 107140 - K Sumoylation 25391492 672 107140 - K Ubiquitination 11927591 672 107140 - K Ubiquitination 17185394 672 107140 - K Sumoylation 22661230

PTM - mUbiSiDa Gene Name Species Ubiquitination Site Ubiquitination Sequence Evidence PMID BRCA1 Homo sapiens (Human) 50 "50,CKFCMLKLLNQKK" 50:21890473 BRCA1 Homo sapiens (Human) 50; 987 "50,CKFCMLKLLNQKK; 987,PPLFPIKSFVKTK" 50:21890473; 987:21890473 BRCA1 Homo sapiens (Human) 457 "457,PPLFPIKSFVKTK" 457:21890473 BRCA1 Homo sapiens (Human) 517 "517,EFMLVYKFARKHH" 517:21906983 BRCA1 Homo sapiens (Human) 516; 50 "516,EFMLVYKFARKHH; 50,CKFCMLKLLNQKK" 516:21906983; 50:21890473 BRCA1 Homo sapiens (Human) 50 "50,CKFCMLKLLNQKK" 50:21890473 BRCA1 Homo sapiens (Human) 50; 987 "50,CKFCMLKLLNQKK; 987,PPLFPIKSFVKTK" 50:21890473; 987:21890473 BRCA1 Homo sapiens (Human) 50 "50,CKFCMLKLLNQKK" 1667:21906983 BRCA1 Homo sapiens (Human) 50 "50,CKFCMLKLLNQKK" 50:21890473 BRCA1 Homo sapiens (Human) 50 "50,CKFCMLKLLNQKK" 50:21890473 BRCA1 Homo sapiens (Human) 50; 987 "50,CKFCMLKLLNQKK; 987,PPLFPIKSFVKTK" 50:21890473; 987:21890473 BRCA1 Homo sapiens (Human) 457 "457,PPLFPIKSFVKTK" 457:21890473 BRCA1 Homo sapiens (Human) 457 "457,PPLFPIKSFVKTK" 457:21890473 BRCA1 Homo sapiens (Human) 457 "457,PPLFPIKSFVKTK" 457:21890473 BRCA1 Homo sapiens (Human) 457 "457,PPLFPIKSFVKTK" 457:21890473 BRCA1 Homo sapiens (Human) 50 "50,CKFCMLKLLNQKK" 50:21890473 BRCA1 Homo sapiens (Human) 50 "50,CKFCMLKLLNQKK" 50:21890473 BRCA1 Homo sapiens (Human) 50; 987 "50,CKFCMLKLLNQKK; 987,PPLFPIKSFVKTK" 50:21890473; 987:21890473 BRCA1 Homo sapiens (Human) 50; 987 "50,CKFCMLKLLNQKK; 987,PPLFPIKSFVKTK" 50:21890473; 987:21890473 BRCA1 Homo sapiens (Human) 50 "50,CKFCMLKLLNQKK" 50:21890473 BRCA1 Homo sapiens (Human) 50 "50,CKFCMLKLLNQKK" 50:21890473 BRCA1 Homo sapiens (Human) 50 "50,CKFCMLKLLNQKK" 50:21890473 BRCA1 Homo sapiens (Human) 50 "50,CKFCMLKLLNQKK" 50:21890473 BRCA1 Homo sapiens (Human) 50; 564 "50,CKFCMLKLLNQKK; 564,EFMLVYKFARKHH" 50:21890473; 564:21906983 BRCA1 Homo sapiens (Human) 50; 987; 1688 "50,CKFCMLKLLNQKK; 987,PPLFPIKSFVKTK; 1688,EFMLVYKFARKHH" 50:21890473; 987:21890473; 1688:21906983 BRCA1 Homo sapiens (Human) 50; 987; 1667 "50,CKFCMLKLLNQKK; 987,PPLFPIKSFVKTK; 1667,EFMLVYKFARKHH" 50:21890473; 987:21890473; 1667:21906983 BRCA1 Homo sapiens (Human) 50; 525 "50,CKFCMLKLLNQKK; 525,EFMLVYKFARKHH" 50:21890473; 525:21906983 BRCA1 Homo sapiens (Human) 970; 33; 1650 "970,PPLFPIKSFVKTK; 33,CKFCMLKLLNQKK; 1650,EFMLVYKFARKHH" 970:21890473; 33:21890473; 1650:21906983 BRCA1 Homo sapiens (Human) 50; 987 "50,CKFCMLKLLNQKK; 987,PPLFPIKSFVKTK" 50:21890473; 987:21890473