iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

PPI - IID
Symbol 1	Symbol 2	PMID	DBs	Evidence Type	Adipose Tissue	Adrenal Gland	Amygdala	Bone	Bone Marrow	Brain	Dorsal Root Ganglia	Eye	Heart	Hindgut	Hypothalamus	Kidney	Liver	Lung	Lymph Nodes	Mammary Gland	Midgut	Neurons	Ovary	Pancreas	Pituitary Gland	Placenta	Prostate	Salivary Gland	Skeletal Muscle	Small Intestine	Spleen	Stomach	Testes	Uterus
USP28	USP20	22626734	biogrid	exp	GP	GP	G	G	GP	GP	G		GP	GP	G	GP	GP	GP	GP	G	GP	GP	GP	GP	G	GP	GP	GP	GP	GP	GP	GP	GP	G
USP28	TRIM55	22626734	biogrid	exp		P				P			GP	P		P	GP	P			P	P		P		P		P	GP	GP		P	GP
USO1	USP28	22939629	biogrid	exp	GP	GP	G	G	GP	GP	G		G	GP	G	GP	GP	GP	GP	G	GP	GP	G	GP	G	GP	GP	GP	GP	GP	GP	GP	GP	G
NSMCE2	USP28	25359778	biogrid	exp	G	G	G	G	G	G	G		G	G	G	G	G	G	G	G	G	G	G	G	G	G	G	G	G	G	G	G	G	G
RFFL	USP28	22626734	biogrid	exp	GP	GP	G	G	GP	GP	G		GP	GP	G	GP	GP	GP	GP	G	GP	GP	GP	P	G	GP	GP	GP	GP	GP	GP	GP	GP	G
PLA2G2A	USP28	22118674	biogrid	exp	GP	GP		G	GP	P	G		GP	GP		P	G	G	G	G	GP	GP	GP	GP		GP	GP	G	GP	GP	G	GP	GP	G
STAMBP	USP28	22626734	biogrid	exp	GP	GP	G	G	GP	GP	G		GP	GP	G	GP	GP	GP	GP	G	GP	GP	GP	GP	G	GP	GP	GP	GP	GP	GP	GP	GP	G
SENP8	USP28	22626734	biogrid	exp	P	P	G		P	GP	G		GP	P	G	GP	P	P	P		P	P	GP	P	G	P	GP	P	GP	GP	P	P	GP
STAM	USP28	22626734	biogrid	exp	GP	GP	G	G	GP	GP	G		GP	GP	G	GP	GP	GP	GP	G	GP	GP	GP	GP	G	GP	GP	GP	G	GP	G	GP	GP	G
CIT	USP28	22939629	biogrid	exp	P	P			P	P			P	P		P	P	P	P		P	P	P			P	P	P	P	P	P	P
BAP1	USP28	22626734	biogrid	exp	GP	GP	G	G	GP	GP	G		GP	GP	G	GP	GP	GP	GP	G	GP	GP	GP	GP	G	GP	GP	GP	GP	GP	GP	GP	GP	G
TRIM63	USP28	22626734	biogrid	exp									G																G	G				G
UCHL3	USP28	22626734	biogrid	exp	GP	GP	G	G	GP	GP	G		GP	GP	G	GP	GP	GP	GP	G	GP	GP	G	GP	G	GP	GP	GP	GP	GP	GP	GP	GP	G
ESPL1	USP28	22626734	biogrid	exp	GP	GP	G	G	GP	GP			GP	GP	G	GP	GP	GP	GP	G	GP	GP	GP	GP	G	GP	P	GP	GP	GP	GP	GP	GP	G
OTUB1	USP28	22626734	biogrid	exp	GP	GP	G	G	GP	GP	G		GP	GP	G	GP	GP	GP	GP	G	GP	GP	GP	GP	G	GP	GP	GP	GP	GP	GP	GP	GP	G
USP28	ZC3H4	22939629	biogrid	exp	GP	GP	G	G	GP	GP	G		GP	GP	G	GP	GP	GP	GP	G	GP	GP	GP	GP	G	GP	GP	GP	GP	GP	GP	GP	GP	G
OTUB2	USP28	22626734	biogrid	exp	P									P				P	P					P		P					P	P	GP
FOXK1	USP28	25609649	intact	exp	GP	GP	G	G	GP	GP	G		GP	GP	G	GP	GP	GP	GP	G	GP	GP	GP	GP	G	GP	GP	GP	GP	GP	GP	GP	GP	G
USP7	USP28	22626734	biogrid	exp	GP	GP	G	G	GP	GP	G		GP	GP	G	GP	GP	GP	GP	G	GP	GP	GP	GP	G	GP	GP	GP	GP	GP	GP	GP	GP	G
USP4	USP28	22626734	biogrid	exp	G	GP	G	G	GP	GP	G		GP	GP	G	GP	GP	GP	GP	G	GP	GP	GP	GP	G	GP	G	GP	GP	GP	G	GP	GP	G
SUMO2	USP28	19615732	biogrid,intact	exp	GP	GP	G	G	GP	GP	G		GP	GP	G	GP	GP	GP	GP	G	GP	GP	GP	GP	G	GP	GP	GP	GP	GP	GP	GP	GP	G
KDM1A	USP28	24075993	biogrid	exp	GP	GP	G	G	GP	GP	G		GP	GP	G	GP	GP	GP	GP	G	GP	GP	GP	GP	G	GP	G	GP	GP	GP	GP	GP	GP	G
USP28	CLSPN	16901786	hprd,biogrid	exp				G	G
MAP3K1	USP28	25260751	biogrid	exp	GP	GP	G	G	GP	GP	G		GP	GP	G	GP	GP	GP	GP	G	GP	GP	GP	GP	G	GP	GP	GP	GP	GP	GP	GP	GP	G
PJA1	USP28	22626734	biogrid	exp	GP	GP	G	G	GP	GP	G		GP	GP	G	GP	G	GP	GP	G	GP	GP	GP	GP	G	GP	GP	GP	GP	GP	GP	GP	GP	G
UCHL1	USP28	22626734	biogrid	exp	G	G	G	G	G	GP	G		G	GP	G	GP	G	G	G	G	G	GP	G	GP	G	G	G	G	G	G	G	G	GP	G
USP28	USP15	22626734	biogrid	exp	G	GP	G	G	GP	GP	G		G	GP	G	GP	GP	GP	GP	G	GP	GP	GP	GP	G	GP	GP	GP	GP	GP	GP	GP	GP	G
ZCCHC8	USP28	22939629	biogrid	exp	GP	GP	G	G	GP	GP	G		GP	GP	G	GP	GP	GP	GP	G	GP	GP	GP	GP	G	GP	GP	GP	GP	GP	GP	GP	GP	G
USP28	USP21	22626734	biogrid	exp	GP	GP	G	G	G	GP	G		GP	GP	G	GP	GP	GP	G	G	GP	GP	G	GP	G	GP	GP	GP	G	GP	G	GP	GP	G
UBC	USP28	25359778,22626734	biogrid	exp	GP	GP	G	G	GP	GP	G		GP	GP	G	GP	GP	GP	GP	G	GP	GP	GP	GP	G	GP	GP	GP	GP	GP	GP	GP	GP	G
TWF1	USP28	22939629	biogrid	exp	GP	GP	G	G	G	G	G		GP	GP	G	GP	GP	G	GP	G	GP	G	G	GP	G	GP	GP	G	G	GP	G	GP	GP	G
COMTD1	USP28	26186194	biogrid	exp	GP	GP	G	G	GP	GP	G		GP	GP	G	GP	G	GP	G	G	GP	GP	G	GP	G	G	GP	GP	GP	GP	GP	GP	P	G
FBXW7	USP28	17558397	biogrid	exp	GP	GP	G	G	GP	GP	G		GP	GP	G	GP	GP	GP	GP	G	GP	GP	G	GP	G	P	GP	GP	GP	GP	GP	GP	GP
JOSD1	USP28	22626734	biogrid	exp	GP	GP	G	G	G	GP	G		GP	GP	G	GP	G	GP	G	G	GP	GP	GP	GP	G	GP	GP	GP	GP	GP	G	GP	G	G
MYC	USP28	17558397,17873522,25716680,23389829	biogrid	exp	GP	GP		G	GP	P	G		GP	GP		GP	GP	GP	GP	G	GP	P	GP	GP		GP	GP	GP	GP	GP	GP	GP	GP	G
USP28	ATXN3L	22626734	biogrid	exp	P	P		G	GP	P	G		P	P		P	P		P		P	P	P	GP		P	P	GP	GP	P		P	GP	G
USP28	USP28	22626734	biogrid	exp	GP	GP	G	G	GP	GP	G		GP	GP	G	GP	GP	GP	GP	G	GP	GP	GP	GP	G	GP	GP	GP	GP	GP	GP	GP	GP	G
RCHY1	USP28	23449389	biogrid	exp	G	GP	G	G	G	GP	G		GP	GP	G	GP	G	GP	G	G	GP	GP	G	GP	G	G	G	GP	G	GP	G	GP	G	G
AQR	USP28	19615732	biogrid,intact	exp	G	G	G	G	G	G	G		G	G	G	G	G	G	G	G	G	G	G	G	G	G	G	G	G	G	G	G	G	G
PFAS	USP28	22939629	biogrid	exp	G	GP	G	G	GP	GP			GP	GP	G	GP	GP		GP	G	GP	GP	GP	P	G	GP	GP	GP	GP	GP	GP	GP	GP	G
ELAVL1	USP28	19322201	biogrid	exp	GP	GP	G	G	GP	GP	G		GP	GP	G	GP	GP	GP	GP	G	GP	GP	GP	GP	G	GP	GP	GP	GP	GP	G	GP	GP	G
TP53BP1	USP28	19615732,16901786	hprd,biogrid,intact	exp	GP	GP	G	G	GP	GP	G		GP	GP	G	GP	GP	GP	GP	G	GP	GP	GP	GP	G	GP	GP	GP	GP	GP	GP	GP	GP	G
USP8	USP28	22626734	biogrid	exp, ortho	G	GP	G	G	GP	GP	G		G	GP	G	GP	G	GP	G	G	GP	GP	G	GP	G	GP	GP	G	GP	GP	G	GP	GP	G
USP51	USP28	22626734	biogrid	exp, ortho	GP	GP	G	G	GP	GP	G		GP	P	G	GP		P	GP	G	P	GP	GP	GP	G	GP	GP	P		P	GP	P	GP
USP33	USP28	22626734	biogrid	exp, ortho	GP	GP	G	G	GP	GP	G		GP	GP	G	GP	GP	GP	GP	G	GP	GP	G	GP	G	GP	GP	GP	GP	GP	G	GP	GP	G
USP14	USP28	22626734	biogrid	exp, ortho	GP	GP	G	G	GP	GP	G		GP	GP	G	GP	GP	GP	GP	G	GP	GP	GP	GP	G	GP	GP	GP	GP	GP	GP	GP	GP	G
USP5	USP28	22626734	biogrid	exp, ortho	GP	GP	G	G	GP	GP	G		GP	GP	G	GP	GP	GP	GP	G	GP	GP	GP	GP	G	GP	GP	G	GP	GP	GP	GP	GP	G
USP28	UCHL5	22626734	biogrid	exp, ortho	GP	GP	G	G	GP	GP	G		GP	GP	G	GP	GP	GP	GP	G	GP	GP	GP	GP	G	GP	GP	GP	GP	GP	GP	GP	GP	G
USP28	USP25	19615732	biogrid,intact	exp, ortho	GP	GP	G	G	GP	GP	G		GP	GP	G	GP	GP	GP	GP	G	GP	GP	GP	GP	G	GP	GP	GP	GP	GP	GP	GP	GP	G
TP53	USP28	22653443, 25402006, 23023127	intact	exp, pred	G	G	G	G	G	G	G		G	G	G	G	G	G	G	G	GP	G	G	G	G	GP	G	G	G	GP	G	G	GP	G
MDC1	USP28	16901786, 25402006	hprd,biogrid	exp, pred	GP	GP	G	G	GP	GP	G		GP	GP	G	GP	GP	GP	GP	G	GP	GP	GP	GP	G	GP	GP	GP	GP	GP	GP	GP	GP	G
USP1	USP28	23023127		pred	GP	GP	G	G	GP	GP	G		G	GP	G	GP	GP	G	GP	G	GP	GP	G	G	G	GP	G	GP	GP	GP	GP	GP	GP	G
USP28	SENP1	21836163		pred	GP	GP	G	G	GP	GP	G		GP	GP	G	GP	GP	GP	GP	G	GP	GP	GP	GP	G	GP	GP	GP	GP	GP	GP	GP	GP	G
NBN	USP28	23023127		pred	GP	GP	G	G	GP	GP	G		GP	GP	G	GP	GP	GP	GP	G	GP	GP	GP	GP	G	GP	GP	GP	G	GP	GP	GP	GP	G
IFI16	USP28	25402006		pred	G	G	G	G	GP	GP	G		G	GP	G	GP	G	G	GP	G	G	GP	GP	G	G	G	G	G	G	G	GP	G	G	G
G2E3	USP28	21836163		pred	G	G	G	G	G	GP	G		G	GP	G	GP	G	G	G	G	G	GP	G		G	G	G	G	G	G	G	G	G
USP28	RAD18	25402006		pred						P				P		P	P		GP		P	P		G		P				P	GP		P
HUWE1	USP28	21836163		pred	GP	GP	G	G	GP	GP	G		GP	GP	G	GP	GP	GP	GP	G	GP	GP	GP	GP	G	GP	GP	GP	GP	GP	GP	GP	GP	G
BRCA1	USP28	25402006, 23023127		pred	P	P		G	GP	P			P	P		P	P	P	P		GP	P	P	P		P	P	P	P	P	P	P	GP
TRIM21	USP28	23023127		pred	GP	GP	G	G	GP	GP	G		GP	GP	G	GP	GP	GP	GP	G	GP	GP	GP	GP	G	GP	GP	GP	GP	GP	GP	GP	GP	G
PAXIP1	USP28	25402006		pred	GP	GP	G	G	GP	GP	G		GP	GP	G	GP	G	GP	GP	G	GP	GP	GP	GP	G	GP	GP	GP	GP	GP	GP	GP	GP	G
E2F1	USP28	25402006		pred	P	GP	G	G	GP	GP	G		GP	GP	G	GP	GP	GP	GP		GP	GP	GP	GP	G	P	P	GP	P	GP	P	GP	GP	G
BLM	USP28	25402006		pred	GP	GP	G	G	GP	GP	G		GP	GP	G	GP	GP	GP	GP	G	GP	GP	GP	GP	G	GP	GP	GP	GP	GP	GP	GP	GP	G
RNF8	USP28	25402006		pred	GP	GP	G	G	G	GP	G		GP	GP	G	GP	G	G	G	G	GP	GP	G	GP	G	G	G	GP	G	GP	G	GP	GP	G
USP28	BBC3	25402006, 21836163		pred
USP28	DNAJB9	21836163		pred	GP	GP	G	G	GP	GP	G		GP	GP	G	GP	GP	GP	GP	G	GP	GP	GP	GP	G	GP	GP	GP	GP	GP	GP	GP	GP	G
DYNLL1	USP28	25402006		pred	G	G	G	G	G	G	G		G	G	G	G	G	G	G	G	G	G	G	G	G	G	G	G	G	G	G	G	G	G

PPI - iRefIndex
UniProt A	UniProt B	Method	PMID	Interaction Type	Edge type	Num Participants
Q93009	Q96RU2	enzymatic study	22626734	direct interaction	X	2
Q92783	Q96RU2	enzymatic study	22626734	direct interaction	X	2
Q70EK9	Q96RU2	enzymatic study	22626734	direct interaction	X	2
Q8NG27	Q96RU2	enzymatic study	22626734	direct interaction	X	2
Q9UHP3	Q96RU2	affinity chromatography technology	19615732	physical association	X	2
P01106	Q96RU2	enzymatic study	17558397	direct interaction	X	2
P01106	Q96RU2	affinity chromatography technology	17558397	physical association	X	2
P01106	Q96RU2	affinity chromatography technology	17873522	physical association	X	2
P01106	Q96RU2	affinity chromatography technology	23389829	physical association	X	2
Q96RU2	Q969Q1	enzymatic study	22626734	direct interaction	X	2
Q96RU2	Q96FW1	enzymatic study	22626734	direct interaction	X	2
Q96RU2		enzymatic study	22626734	direct interaction	X	2
Q96RU2	Q8TEY7	enzymatic study	22626734	direct interaction	X	2
Q96RU2	Q9Y4E8-2	enzymatic study	22626734	direct interaction	X	2
Q96RU2	Q14674	enzymatic study	22626734	direct interaction	X	2
Q96RU2	P54578-3	enzymatic study	22626734	direct interaction	X	2
Q96RU2	A0A024RDG1	biochemical	22939629	colocalization	X	2
Q96RU2	Q9HAW4	affinity chromatography technology	16901786	physical association	X	2
Q9H3M9	Q96RU2	enzymatic study	22626734	direct interaction	X	2
Q8WZ73	Q96RU2	enzymatic study	22626734	direct interaction	X	2
A8K8D3	Q96RU2	enzymatic study	22626734	direct interaction	X	2
A0A024R9J6	Q96RU2	enzymatic study	25359778	direct interaction	X	2
A0A024RA96	Q96RU2	enzymatic study	22118674	direct interaction	X	2
P45974-2	Q96RU2	enzymatic study	22626734	direct interaction	X	2
Q9Y2K6	Q96RU2	enzymatic study	22626734	direct interaction	X	2
Q96DC9	Q96RU2	enzymatic study	22626734	direct interaction	X	2
O60306	Q96RU2	affinity chromatography technology	19615732	physical association	X	2
Q12888	Q96RU2	affinity chromatography technology	19615732	physical association	X	2
Q12888	Q96RU2	affinity chromatography technology	16901786	physical association	X	2
Q12888	Q96RU2	affinity chromatography technology	16901786	physical association	X	2
Q12888	Q96RU2	affinity chromatography technology	16901786	physical association	X	2
Q96RU2	Q969H0-4	affinity chromatography technology	17558397	physical association	X	2
Q96RU2	Q9BYV6-4	enzymatic study	22626734	direct interaction	X	2
Q96RU2	Q9UK80	enzymatic study	22626734	direct interaction	X	2
Q96RU2	Q15040	enzymatic study	22626734	direct interaction	X	2
Q96RU2	P15374	enzymatic study	22626734	direct interaction	X	2
Q96RU2		enzymatic study	22626734	direct interaction	X	2
Q96RU2	Q96RU2	enzymatic study	22626734	direct interaction	X	2
Q96RU2	P09936	enzymatic study	22626734	direct interaction	X	2
Q96RU2	Q9UK80	enzymatic study	22626734	direct interaction	X	2
Q96RU2	Q13107-3	enzymatic study	22626734	direct interaction	X	2
Q96RU2	Q12792-3	biochemical	22939629	colocalization	X	2
Q96RU2	Q6NZY4	biochemical	22939629	colocalization	X	2
Q96RU2	O14578	biochemical	22939629	colocalization	X	2
Q96RU2	O15067	biochemical	22939629	colocalization	X	2
Q96RU2	Q96PM5-2	affinity chromatography technology	23449389	physical association	X	2
Q96RU2	O60341	affinity chromatography technology	24075993	physical association	X	2
Q96RU2	O60341	affinity chromatography technology	24075993	physical association	X	2
Q96RU2	O60341	pull down	24075993	direct interaction	X	2
Q96RU2	O60341	enzymatic study	24075993	direct interaction	X	2
Q96RU2	P61956-2	affinity chromatography technology	19615732	physical association	X	2
Q96RU2	Q14676	affinity chromatography technology	16901786	physical association	X	2
Q96RU2	P61956-2	affinity chromatography technology	19471022	physical association	X	2
Q96RU2	P61956-2	affinity chromatography technology	21252943	physical association	X	2
A0A024R305	Q96RU2	enzymatic study	22626734	direct interaction	X	2
Q9UPT8	Q96RU2	biochemical	22939629	colocalization	X	2
P0CG48	Q96RU2	enzymatic study	22626734	direct interaction	X	2
P0CG48	Q96RU2	affinity chromatography technology	21963094	physical association	X	2
P0CG48	Q96RU2	affinity chromatography technology	23000965	physical association	X	2
P0CG48	Q96RU2	enzymatic study	25359778	direct interaction	X	2
P0CG48	Q96RU2	pull down	19850743	direct interaction	X	2
P0CG48	Q96RU2	affinity chromatography technology	22118674	physical association	X	2
P0CG48	Q96RU2	affinity chromatography technology	21139048	physical association	X	2
P0CG48	Q96RU2	affinity chromatography technology	21890473	physical association	X	2
P0CG48	Q96RU2	affinity chromatography technology	21906983	physical association	X	2
O95630	Q96RU2	enzymatic study	22626734	direct interaction	X	2
Q96RU2	Q9HAW4	in vitro	16901786	-	X	2
Q96RU2	Q9HAW4	in vivo	16901786	-	X	2
Q96RU2	Q9HAW4	in vivo	16901786	-	X	2
Q96RU2	Q9HAW4	in vitro	16901786	-	X	2
Q12888	Q96RU2	in vitro	16901786	-	X	2
Q12888	Q96RU2	in vitro	16901786	-	X	2
Q96RU2	Q14676	in vivo	16901786	-	X	2
Q96RU2	Q14676	in vivo	16901786	-	X	2
	Q96RU2	anti tag coimmunoprecipitation	19615732	physical association	C	4
	Q96RU2	anti tag coimmunoprecipitation	22653443	association	C	51
	Q96RU2	ubiquitinase assay	25260751	ubiquitination reaction	C	5
	Q96RU2	anti tag coimmunoprecipitation	19615732	physical association	C	14
Q5NID2	Q96RU2	two hybrid pooling approach	20711500	physical association	X	2

PPI - PINA
Gene A	Gene B	Method	Publications	Species A	Species B	Interaction Type	Source Database	Interaction Identidiers	Experimental Role(s) Interactor A	Experimental Role(s) Interactor B
PLA2G2A	USP28	MI:0415(enzymatic study)	22118674	taxid:9606(Homo sapiens)	taxid:9606(Homo sapiens)	MI:0407(direct interaction)	(biogrid)	BIOGRID_160302	prey	bait
OTUB2	USP28	MI:0415(enzymatic study)	22626734	taxid:9606(Homo sapiens)	taxid:9606(Homo sapiens)	MI:0407(direct interaction)	(biogrid)	BIOGRID_223120	prey	bait
USP28	UCHL5	MI:0415(enzymatic study)	22626734	taxid:9606(Homo sapiens)	taxid:9606(Homo sapiens)	MI:0407(direct interaction)	(biogrid)	BIOGRID_223119	bait	prey
USP28	USP15	MI:0415(enzymatic study)	22626734	taxid:9606(Homo sapiens)	taxid:9606(Homo sapiens)	MI:0407(direct interaction)	(biogrid)	BIOGRID_223123	bait	prey
USP7	USP28	MI:0415(enzymatic study)	22626734	taxid:9606(Homo sapiens)	taxid:9606(Homo sapiens)	MI:0407(direct interaction)	(biogrid)	BIOGRID_223113	prey	bait
ELAVL1	USP28	MI:0096(pull down)	19322201	taxid:9606(Homo sapiens)	taxid:9606(Homo sapiens)	MI:0915(physical association)	(biogrid)	BIOGRID_186748	bait	prey
USP28	USP20	MI:0415(enzymatic study)	22626734	taxid:9606(Homo sapiens)	taxid:9606(Homo sapiens)	MI:0407(direct interaction)	(biogrid)	BIOGRID_223110	bait	prey
STAMBP	USP28	MI:0415(enzymatic study)	22626734	taxid:9606(Homo sapiens)	taxid:9606(Homo sapiens)	MI:0407(direct interaction)	(biogrid)	BIOGRID_223114	prey	bait
PJA1	USP28	MI:0415(enzymatic study)	22626734	taxid:9606(Homo sapiens)	taxid:9606(Homo sapiens)	MI:0407(direct interaction)	(biogrid)	BIOGRID_222993	bait	prey
USP4	USP28	MI:0415(enzymatic study)	22626734	taxid:9606(Homo sapiens)	taxid:9606(Homo sapiens)	MI:0407(direct interaction)	(biogrid)	BIOGRID_223133	prey	bait
SUMO2	USP28	MI:0007(anti tag coimmunoprecipitation)\|MI:0004(affinity chromatography technology)\|MI:0004(affinity chromatography technology)\|MI:0004(affinity chromatography technology)	19471022,19615732,21252943	taxid:9606(Homo sapiens)	taxid:9606(Homo sapiens)	MI:0915(physical association)\|MI:0915(physical association)\|MI:0915(physical association)\|MI:0915(physical association)	(intact)\|(biogrid)\|(biogrid)\|(biogrid)	UniProt_100669\|BIOGRID_183987\|BIOGRID_119802\|BIOGRID_183444	prey\|bait\|prey\|bait	bait\|prey\|bait\|prey
PFAS	USP28	MI:0401(biochemical)	22939629	taxid:9606(Homo sapiens)	taxid:9606(Homo sapiens)	MI:0403(colocalization)	(biogrid)	BIOGRID_243368	bait	prey
USP28	RFFL	MI:0415(enzymatic study)	22626734	taxid:9606(Homo sapiens)	taxid:9606(Homo sapiens)	MI:0407(direct interaction)	(biogrid)	BIOGRID_222977	prey	bait
RCHY1	USP28	MI:0004(affinity chromatography technology)	23449389	taxid:9606(Homo sapiens)	taxid:9606(Homo sapiens)	MI:0915(physical association)	(biogrid)	BIOGRID_258355	bait	prey
AQR	USP28	MI:0004(affinity chromatography technology)\|MI:0007(anti tag coimmunoprecipitation)	19615732	taxid:9606(Homo sapiens)	taxid:9606(Homo sapiens)	MI:0915(physical association)\|MI:0915(physical association)	(biogrid)\|(intact)	BIOGRID_120089\|UniProt_100669	prey\|prey	bait\|bait
USP28	TRIM55	MI:0415(enzymatic study)	22626734	taxid:9606(Homo sapiens)	taxid:9606(Homo sapiens)	MI:0407(direct interaction)	(biogrid)	BIOGRID_223031	prey	bait
USP51	USP28	MI:0415(enzymatic study)	22626734	taxid:9606(Homo sapiens)	taxid:9606(Homo sapiens)	MI:0407(direct interaction)	(biogrid)	BIOGRID_223111	prey	bait
MDC1	USP28	MI:0492(in vitro)\|MI:0004(affinity chromatography technology)	16901786	taxid:9606(Homo sapiens)	taxid:9606(Homo sapiens)	-\|MI:0915(physical association)	MI:0468(hprd)\|(biogrid)	HPRD_32310\|BIOGRID_122978	-\|prey	-\|bait
USP28	CLSPN	MI:0004(affinity chromatography technology)\|MI:0492(in vitro)	16901786	taxid:9606(Homo sapiens)	taxid:9606(Homo sapiens)	MI:0915(physical association)\|-	(biogrid)\|MI:0468(hprd)	BIOGRID_122977\|HPRD_32309	bait\|-	prey\|-
USP28	ATXN3L	MI:0415(enzymatic study)	22626734	taxid:9606(Homo sapiens)	taxid:9606(Homo sapiens)	MI:0407(direct interaction)	(biogrid)	BIOGRID_223121	bait	prey
JOSD1	USP28	MI:0415(enzymatic study)	22626734	taxid:9606(Homo sapiens)	taxid:9606(Homo sapiens)	MI:0407(direct interaction)	(biogrid)	BIOGRID_223116	prey	bait
BAP1	USP28	MI:0415(enzymatic study)	22626734	taxid:9606(Homo sapiens)	taxid:9606(Homo sapiens)	MI:0407(direct interaction)	(biogrid)	BIOGRID_223129	prey	bait
STAM	USP28	MI:0415(enzymatic study)	22626734	taxid:9606(Homo sapiens)	taxid:9606(Homo sapiens)	MI:0407(direct interaction)	(biogrid)	BIOGRID_223128	prey	bait
MYC	USP28	MI:0004(affinity chromatography technology)\|MI:0415(enzymatic study)\|MI:0004(affinity chromatography technology)\|MI:0415(enzymatic study)	17558397,17873522,23389829	taxid:9606(Homo sapiens)	taxid:9606(Homo sapiens)	MI:0915(physical association)\|MI:0915(physical association)\|MI:0915(physical association)\|MI:0407(direct interaction)	(biogrid)\|(biogrid)\|(biogrid)\|(biogrid)	BIOGRID_199682\|BIOGRID_199275\|BIOGRID_281354\|BIOGRID_199274	bait\|prey\|prey\|prey	prey\|bait\|bait\|bait
UBC	USP28	MI:0004(affinity chromatography technology)\|MI:0004(affinity chromatography technology)\|MI:0004(affinity chromatography technology)\|MI:0004(affinity chromatography technology)\|MI:0004(affinity chromatography technology)\|MI:0415(enzymatic study)\|MI:0004(affinity chromatography technology)\|MI:0415(enzymatic study)	19850743,21139048,21890473,21906983,21963094,22118674,22626734,23000965	taxid:9606(Homo sapiens)	taxid:9606(Homo sapiens)	MI:0407(direct interaction)\|MI:0915(physical association)\|MI:0915(physical association)\|MI:0915(physical association)\|MI:0915(physical association)\|MI:0915(physical association)\|MI:0915(physical association)\|MI:0407(direct interaction)	(biogrid)\|(biogrid)\|(biogrid)\|(biogrid)\|(biogrid)\|(biogrid)\|(biogrid)\|(biogrid)	BIOGRID_149149\|BIOGRID_175387\|BIOGRID_269776\|BIOGRID_265881\|BIOGRID_170787\|BIOGRID_160542\|BIOGRID_180015\|BIOGRID_223132	bait\|bait\|bait\|bait\|bait\|bait\|bait\|prey	prey\|prey\|prey\|prey\|prey\|prey\|prey\|bait
UCHL3	USP28	MI:0415(enzymatic study)	22626734	taxid:9606(Homo sapiens)	taxid:9606(Homo sapiens)	MI:0407(direct interaction)	(biogrid)	BIOGRID_223117	prey	bait
USO1	USP28	MI:0401(biochemical)	22939629	taxid:9606(Homo sapiens)	taxid:9606(Homo sapiens)	MI:0403(colocalization)	(biogrid)	BIOGRID_240255	prey	bait
USP8	USP28	MI:0415(enzymatic study)	22626734	taxid:9606(Homo sapiens)	taxid:9606(Homo sapiens)	MI:0407(direct interaction)	(biogrid)	BIOGRID_223118	prey	bait
ZCCHC8	USP28	MI:0401(biochemical)	22939629	taxid:9606(Homo sapiens)	taxid:9606(Homo sapiens)	MI:0403(colocalization)	(biogrid)	BIOGRID_241332	prey	bait
OTUB1	USP28	MI:0415(enzymatic study)	22626734	taxid:9606(Homo sapiens)	taxid:9606(Homo sapiens)	MI:0407(direct interaction)	(biogrid)	BIOGRID_223115	prey	bait
TP53BP1	USP28	MI:0007(anti tag coimmunoprecipitation)\|MI:0004(affinity chromatography technology)\|MI:0492(in vitro)\|MI:0004(affinity chromatography technology)\|MI:0004(affinity chromatography technology)\|MI:0004(affinity chromatography technology)	16901786,19615732	taxid:9606(Homo sapiens)	taxid:9606(Homo sapiens)	MI:0915(physical association)\|MI:0915(physical association)\|-\|MI:0915(physical association)\|MI:0915(physical association)\|MI:0915(physical association)	(intact)\|(biogrid)\|MI:0468(hprd)\|(biogrid)\|(biogrid)\|(biogrid)	UniProt_100669\|BIOGRID_122976\|HPRD_32307\|BIOGRID_119831\|BIOGRID_122975\|BIOGRID_122974	prey\|prey\|-\|prey\|bait\|bait	bait\|bait\|-\|bait\|prey\|prey
TRIM63	USP28	MI:0415(enzymatic study)	22626734	taxid:9606(Homo sapiens)	taxid:9606(Homo sapiens)	MI:0407(direct interaction)	(biogrid)	BIOGRID_223010	bait	prey
USP33	USP28	MI:0415(enzymatic study)	22626734	taxid:9606(Homo sapiens)	taxid:9606(Homo sapiens)	MI:0407(direct interaction)	(biogrid)	BIOGRID_223122	prey	bait
FBXW7	USP28	MI:0415(enzymatic study)	17558397	taxid:9606(Homo sapiens)	taxid:9606(Homo sapiens)	MI:0915(physical association)	(biogrid)	BIOGRID_199285	prey	bait
CIT	USP28	MI:0401(biochemical)	22939629	taxid:9606(Homo sapiens)	taxid:9606(Homo sapiens)	MI:0403(colocalization)	(biogrid)	BIOGRID_241660	bait	prey
USP14	USP28	MI:0415(enzymatic study)	22626734	taxid:9606(Homo sapiens)	taxid:9606(Homo sapiens)	MI:0407(direct interaction)	(biogrid)	BIOGRID_223127	prey	bait
ESPL1	USP28	MI:0415(enzymatic study)	22626734	taxid:9606(Homo sapiens)	taxid:9606(Homo sapiens)	MI:0407(direct interaction)	(biogrid)	BIOGRID_223125	prey	bait
SENP8	USP28	MI:0415(enzymatic study)	22626734	taxid:9606(Homo sapiens)	taxid:9606(Homo sapiens)	MI:0407(direct interaction)	(biogrid)	BIOGRID_223126	prey	bait
NRF1	USP28	MI:0428(imaging technique)	24250222	taxid:9606(Homo sapiens)	taxid:9606(Homo sapiens)	MI:0403(colocalization)	(biogrid)	BIOGRID_296171	bait	prey
USP5	USP28	MI:0415(enzymatic study)	22626734	taxid:9606(Homo sapiens)	taxid:9606(Homo sapiens)	MI:0407(direct interaction)	(biogrid)	BIOGRID_223112	prey	bait
UCHL1	USP28	MI:0415(enzymatic study)	22626734	taxid:9606(Homo sapiens)	taxid:9606(Homo sapiens)	MI:0407(direct interaction)	(biogrid)	BIOGRID_223130	prey	bait
USP28	USP25	MI:0004(affinity chromatography technology)\|MI:0007(anti tag coimmunoprecipitation)	19615732	taxid:9606(Homo sapiens)	taxid:9606(Homo sapiens)	MI:0915(physical association)\|MI:0915(physical association)	(biogrid)\|(intact)	BIOGRID_120611\|UniProt_100690	prey\|prey	bait\|bait
TWF1	USP28	MI:0401(biochemical)	22939629	taxid:9606(Homo sapiens)	taxid:9606(Homo sapiens)	MI:0403(colocalization)	(biogrid)	BIOGRID_240207	bait	prey
USP28	USP21	MI:0415(enzymatic study)\|MI:0415(enzymatic study)	22626734	taxid:9606(Homo sapiens)	taxid:9606(Homo sapiens)	MI:0407(direct interaction)\|MI:0407(direct interaction)	(biogrid)\|(biogrid)	BIOGRID_223081\|BIOGRID_223131	prey\|bait	bait\|prey
USP28	ZC3H4	MI:0401(biochemical)	22939629	taxid:9606(Homo sapiens)	taxid:9606(Homo sapiens)	MI:0403(colocalization)	(biogrid)	BIOGRID_237484	bait	prey

PPI - HINT
Gene A	Gene B	PMID	Method	Quality
CIT	USP28	22939629	0401	HT
PFAS	USP28	22939629	0401	HT
AQR	USP28	19615732,19615732	0004,0007	HT
USO1	USP28	22939629	0401	HT
MYC	USP28	17873522,17558397,17558397,25716680,23389829	0004,0004,0415,0004,0004	LC
UBC	USP28	26268556,19850743,26268556,26268556,22118674	0114,0096,0415,0096,0004	LC
SUMO2	USP28	26268556,21252943,19615732,19615732,26268556	0114,0004,0004,0007,0096	LC,HT
FOXK1	USP28	25609649,25609649	0676,0004	HT
TWF1	USP28	22939629	0401	HT
TP53BP1	USP28	19615732,19615732,16901786	0004,0007,0004	HT,LC
ZCCHC8	USP28	22939629	0401	HT
COMTD1	USP28	26186194	0004	HT
USP28	USP25	19615732,19615732	0004,0007	HT
USP28	ZC3H4	22939629	0401	HT
CIT	USP28	22939629	0401	HT
PFAS	USP28	22939629	0401	HT
AQR	USP28	19615732,19615732	0004,0007	HT
USO1	USP28	22939629	0401	HT
SUMO2	USP28	19615732,19615732	0004,0007	HT
FOXK1	USP28	25609649,25609649	0676,0004	HT
TWF1	USP28	22939629	0401	HT
TP53BP1	USP28	19615732,19615732	0004,0007	HT
ZCCHC8	USP28	22939629	0401	HT
COMTD1	USP28	26186194	0004	HT
USP28	USP25	19615732,19615732	0004,0007	HT
USP28	ZC3H4	22939629	0401	HT
MYC	USP28	17873522,17558397,17558397,25716680,23389829	0004,0004,0415,0004,0004	LC
UBC	USP28	26268556,19850743,26268556,26268556,22118674	0114,0096,0415,0096,0004	LC
SUMO2	USP28	26268556,21252943,26268556	0114,0004,0096	LC
TP53BP1	USP28	16901786	0004	LC
CIT	USP28	22939629	0401	LC
PFAS	USP28	22939629	0401	LC
KDM1A	USP28	24075993,24075993,24075993	0004,0096,0415	LC
USO1	USP28	22939629	0401	LC
STAMBP	USP28	22626734	0415	HT
MYC	USP28	17558397,17558397	0004,0415	LC
UBC	USP28	22626734,26268556,25359778,26268556,26268556	0415,0114,0415,0415,0096	HT,LC
PLA2G2A	USP28	22118674	0415	LC
UCHL3	USP28	22626734	0415	HT
USP8	USP28	22626734	0415	HT
USP5	USP28	22626734	0415	HT
MTNR1A	USP28	26514267	0018	LC
USP14	USP28	22626734	0415	HT
SUMO2	USP28	26268556,26268556	0114,0096	LC
TWF1	USP28	22939629	0401	LC
USP4	USP28	22626734	0415	HT
MAP3K1	USP28	25260751	0415	LC
ESPL1	USP28	22626734	0415	HT
JOSD1	USP28	22626734	0415	HT
ZCCHC8	USP28	22939629	0401	LC
USP51	USP28	22626734	0415	HT
PJA1	USP28	22626734	0415	HT
USP33	USP28	22626734	0415	HT
RFFL	USP28	22626734	0415	HT
BAP1	USP28	22626734	0415	HT
STAM	USP28	22626734	0415	HT
USP7	USP28	22626734	0415	HT
TRIM63	USP28	22626734	0415	HT
OTUB2	USP28	22626734	0415	HT
OTUB1	USP28	22626734	0415	HT
SENP8	USP28	22626734	0415	HT
NSMCE2	USP28	25359778	0415	LC
USP28	USP28	22626734	0415	HT
USP28	TRIM55	22626734	0415	HT
USP28	ATXN3L	22626734	0415	HT
USP28	USP21	22626734	0415	HT
USP28	ZC3H4	22939629	0401	LC
USP28	USP20	22626734	0415	HT
USP28	USP15	22626734	0415	HT
USP28	UCHL5	22626734	0415	HT
USP28	HEL-117	22626734	0415	HT

PPI - Mentha
Protein A	Protein B	Gene A	Gene B	Score	PMID
Q96RU2	A2AU89	USP28	A2AU89	0.126	26496610
Q96RU2	O15067	USP28	PFAS	0.081	22939629
Q96RU2	Q8NG27	USP28	PJA1	0.183	22626734
Q96RU2	Q62925	USP28	MAP3K1	0.033	25260751
Q96RU2	Q86VU5	USP28	COMTD1	0.126	26186194
Q96RU2	P04637	USP28	TP53	0.126	22653443
Q96RU2	P01106	USP28	MYC	0.787	17873522,23389829,25716680,17558397
Q9UHP3	Q96RU2	USP25	USP28	0.236	19615732
Q96RU2	O60306	USP28	AQR	0.236	19615732
Q96RU2	O60341	USP28	KDM1A	0.702	24075993
Q9CQR6	Q96RU2	PPP6C	USP28	0.236	26496610
Q96RU2	P85037	USP28	FOXK1	0.236	25609649
Q96RU2	P61956	USP28	SUMO2	0.636	26268556,19615732
Q96RU2	P0CG48	USP28	UBC	0.814	22626734,26268556,25359778
Q96RU2	Q969Q1	USP28	TRIM63	0.183	22626734
Q96RU2	Q8WZ73	USP28	RFFL	0.183	22626734
Q96RU2	Q96MF7	USP28	NSMCE2	0.309	25359778
Q96RU2	Q96PM5	USP28	RCHY1	0.21	23449389
Q96RU2	Q13107	USP28	USP4	0.183	22626734
Q96RU2	P54578	USP28	USP14	0.183	22626734
Q96RU2	O60763	USP28	USO1	0.081	22939629
Q96RU2	O95630	USP28	STAMBP	0.183	22626734
Q96RU2	P45974	USP28	USP5	0.183	22626734
Q96RU2	P09936	USP28	UCHL1	0.183	22626734
Q96RU2	P40818	USP28	USP8	0.183	22626734
Q96RU2	P14555	USP28	PLA2G2A	0.309	22118674
Q96RU2	P15374	USP28	UCHL3	0.183	22626734
Q96RU2	Q92560	USP28	BAP1	0.183	22626734
Q96RU2	Q15040	USP28	JOSD1	0.183	22626734
Q9Y2K6	Q96RU2	USP20	USP28	0.183	22626734
Q96RU2	Q14676	USP28	MDC1	0.21	16901786
Q96RU2	Q14674	USP28	ESPL1	0.183	22626734
Q96RU2	Q5NID2	USP28	RPOB	0.126	20711500
Q96RU2	Q8TEY7	USP28	USP33	0.183	22626734
Q96RU2	Q6NZY4	USP28	ZCCHC8	0.081	22939629
Q96RU2	Q70EK9	USP28	USP51	0.183	22626734
Q9UPT8	Q96RU2	ZC3H4	USP28	0.081	22939629
Q96RU2	Q96LD8	USP28	SENP8	0.183	22626734
Q96RU2	Q92783	USP28	STAM	0.183	22626734
Q96RU2	Q93009	USP28	USP7	0.183	22626734
Q96RU2	Q96FW1	USP28	OTUB1	0.183	22626734
Q96RU2	Q969H0	USP28	FBXW7	0.21	17558397
Q96RU2	Q96DC9	USP28	OTUB2	0.183	22626734
Q9H3M9	Q96RU2	ATXN3L	USP28	0.183	22626734
Q96RU2	Q96RU2	USP28	USP28	0.21	22626734
Q9UK80	Q96RU2	USP21	USP28	0.332	22626734
Q9HAW4	Q96RU2	CLSPN	USP28	0.21	16901786
Q9Y5K5	Q96RU2	UCHL5	USP28	0.183	22626734
Q9Y4E8	Q96RU2	USP15	USP28	0.183	22626734
Q9BYV6	Q96RU2	TRIM55	USP28	0.183	22626734
Q96RU2	P70399	USP28	TP53BP1	0.126	26496610
Q96RU2	P48039	USP28	MTNR1A	0.183	26514267
Q96RU2	Q12792	USP28	TWF1	0.081	22939629
Q96RU2	Q12888	USP28	TP53BP1	0.523	19615732,16901786
Q96RU2	Q15717	USP28	ELAVL1	0.126	19322201
Q96RU2	Q13233	USP28	MAP3K1	0.183	25260751
Q96RU2	O14578	USP28	CIT	0.081	22939629

PPI - InWeb_IM
Gene A	Gene B	MI 1	Interaction 1	MI 2	Interaction 2
PPP6C	USP28	MI:0362	inference	MI:0461	interaction database
AQR	USP28	MI:0045	experimental interaction detection	MI:0461	interaction database
KDM1A	USP28	MI:0045	experimental interaction detection	MI:0461	interaction database
STAMBP	USP28	MI:0045	experimental interaction detection	MI:0461	interaction database
MYC	USP28	MI:0045	experimental interaction detection	MI:0461,MI:1106	interaction database,pathways database
TP53	USP28	MI:0045	experimental interaction detection	MI:0461	interaction database
UCHL1	USP28	MI:0045	experimental interaction detection	MI:0461	interaction database
UBC	USP28	MI:0045	experimental interaction detection	MI:0461	interaction database
PLA2G2A	USP28	MI:0045	experimental interaction detection	MI:0461	interaction database
UCHL3	USP28	MI:0045	experimental interaction detection	MI:0461	interaction database
USP8	USP28	MI:0045	experimental interaction detection	MI:0461	interaction database
USP5	USP28	MI:0045	experimental interaction detection	MI:0461	interaction database
MTNR1A	USP28	MI:0045	experimental interaction detection	MI:0461	interaction database
USP14	USP28	MI:0045	experimental interaction detection	MI:0461	interaction database
SUMO2	USP28	MI:0045	experimental interaction detection	MI:0461	interaction database
FOXK1	USP28	MI:0045	experimental interaction detection	MI:0461	interaction database
TP53BP1	USP28	MI:0045	experimental interaction detection	MI:0461	interaction database
USP4	USP28	MI:0045	experimental interaction detection	MI:0461	interaction database
MAP3K1	USP28	MI:0045	experimental interaction detection	MI:0461	interaction database
ESPL1	USP28	MI:0045	experimental interaction detection	MI:0461	interaction database
MDC1	USP28	MI:0045	experimental interaction detection	MI:0461	interaction database
JOSD1	USP28	MI:0045	experimental interaction detection	MI:0461	interaction database
ELAVL1	USP28	MI:0045	experimental interaction detection	MI:0461	interaction database
USP51	USP28	MI:0045	experimental interaction detection	MI:0461	interaction database
COMTD1	USP28	MI:0045	experimental interaction detection	MI:0461	interaction database
PJA1	USP28	MI:0045	experimental interaction detection	MI:0461	interaction database
USP33	USP28	MI:0045	experimental interaction detection	MI:0461	interaction database
RFFL	USP28	MI:0045	experimental interaction detection	MI:0461	interaction database
BAP1	USP28	MI:0045	experimental interaction detection	MI:0461	interaction database
STAM	USP28	MI:0045	experimental interaction detection	MI:0461	interaction database
USP7	USP28	MI:0045	experimental interaction detection	MI:0461	interaction database
FBXW7	USP28	MI:0045	experimental interaction detection	MI:0461	interaction database
TRIM63	USP28	MI:0045	experimental interaction detection	MI:0461	interaction database
OTUB2	USP28	MI:0045	experimental interaction detection	MI:0461	interaction database
OTUB1	USP28	MI:0045	experimental interaction detection	MI:0461	interaction database
SENP8	USP28	MI:0045	experimental interaction detection	MI:0461	interaction database
NSMCE2	USP28	MI:0045	experimental interaction detection	MI:0461	interaction database
RCHY1	USP28	MI:0045	experimental interaction detection	MI:0461	interaction database
USP28	TRIM55	MI:0045	experimental interaction detection	MI:0461	interaction database
USP28	ATXN3L	MI:0045	experimental interaction detection	MI:0461	interaction database
USP28	CLSPN	MI:0045	experimental interaction detection	MI:0461,MI:1106	interaction database,pathways database
USP28	USP25	MI:0045	experimental interaction detection	MI:0461	interaction database
USP28	USP21	MI:0045	experimental interaction detection	MI:0461	interaction database
USP28	USP20	MI:0045	experimental interaction detection	MI:0461	interaction database
USP28	USP15	MI:0045	experimental interaction detection	MI:0461	interaction database
USP28	UCHL5	MI:0045	experimental interaction detection	MI:0461	interaction database