PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus FNBP1L USP13 16169070 hprd,biogrid,i2d,mint,intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G THOC7 USP13 22939629 biogrid exp GP GP G G GP GP G G GP G GP G GP GP G GP GP GP GP G GP GP GP G GP G GP GP G BAG6 USP13 24424410,19615732 biogrid,intact exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP G GP GP G USP13 SMC3 26496610,19615732 biogrid,intact exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP G GP GP G GET4 USP13 24424410 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP G GP GP G SPRR2D USP13 16169070 intact exp UFD1L USP13 19615732,21571647 biogrid,intact exp G GP G G G GP G GP GP G GP G GP GP G GP GP G GP G GP GP G GP GP G G GP G USP13 RPP25 26186194 biogrid exp GP GP G G GP GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP P GP G GP GP G LAPTM5 USP13 15231748 hprd,biogrid,i2d,mint,intact exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G G GP GP G GP G GP GP G USP13 TCAF1 19615732 biogrid,intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G SPRR2C USP13 16169070 hprd,mint exp USP13 MYO15A 16169070 hprd,biogrid,i2d,mint,intact exp GP G G G G GP G G GP G GP G G G G GP GP GP GP G GP G G GP GP GP GP G USP13 FUNDC2 16169070 hprd,biogrid,i2d,mint,intact exp G GP G G GP GP G GP GP G GP G G G G GP GP G GP G G G GP GP GP G GP GP G USP13 THOC1 22939629 biogrid exp G GP G G GP GP G GP GP G GP G GP GP G GP GP GP GP G GP GP G GP GP G GP GP G DVL1 USP13 16169070 hprd,biogrid,i2d,mint,intact exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP G GP GP G USP13 MRPL20 16169070 hprd,biogrid,i2d,mint,intact exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP G GP G GP GP G OGDH USP13 19615732 biogrid,intact exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP G GP GP G SIAH2 USP13 21659512 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G STAT1 USP13 23940278 biogrid exp G G G G GP GP G G GP G GP G GP GP G GP GP G GP G GP GP G G GP G G GP G USP13 KCTD10 19615732 biogrid,intact exp G GP G G GP GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP GP GP G GP GP G NPLOC4 USP13 19615732 biogrid,intact exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP G GP GP G USP13 DIABLO 19615732 biogrid,intact exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP G GP GP G SCCPDH USP13 26186194 biogrid exp G GP G G G G G G G G G GP GP GP G G G GP G G G G G G G G GP GP G USP13 CYLD 19615732 biogrid,intact exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP P G GP GP GP GP GP G GP GP USP13 FAF2 19615732 biogrid,intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G UBL4A USP13 24424410,19615732 biogrid,intact exp GP GP G G G GP G G GP G GP G G G G G GP G GP G GP G G G G G GP P G USP13 L1RE1 16169070 intact exp SYNCRIP USP13 26496610 biogrid,intact exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP G GP GP G USP13 KCTD3 19615732 biogrid,intact exp G GP G GP G GP GP G G G G GP G GP GP GP GP G GP GP GP GP GP G GP GP G DLST USP13 19615732 biogrid,intact exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP G GP GP G USP13 CACYBP 19615732 biogrid,intact exp GP GP G G GP GP G G GP G GP GP GP GP G GP GP GP GP G GP GP GP G GP G GP GP G ATXN3 USP13 19615732 biogrid,intact exp GP GP G G GP GP G GP GP G GP G GP GP G P GP GP P G GP GP GP GP GP G GP GP G UBE3C USP13 22939629 biogrid exp G GP G G GP GP G GP GP G GP GP GP G G GP GP G GP G GP GP GP GP GP G GP GP G UBC USP13 23314748,22216260 biogrid exp, ortho GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP G GP GP G USP13 TRIM55 11927605 hprd,biogrid exp, ortho P P GP P P GP P P P P P P GP GP P GP USP13 MOV10 22658674 biogrid exp, ortho G G G G G G G G G G G G G G G G G G G G G G PTEN USP13 24270891 biogrid exp, ortho GP GP G G GP GP G G GP G GP G GP GP G GP GP G GP G GP G GP G GP G GP GP G SMC1A USP13 26496610,19615732 biogrid,intact exp, ortho GP GP G G GP GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP GP GP G GP GP G USP13 ITCH 19615732 biogrid,intact exp, ortho GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP G GP GP G USP13 YTHDF2 26344197 biogrid exp, ortho GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP G GP G GP GP G SKP2 USP13 21571647 biogrid exp, ortho GP GP G G GP GP G GP GP G G GP GP GP G GP GP G GP G GP G G GP GP G GP GP G NEDD8 USP13 19615732 biogrid,intact exp, ortho GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP G GP GP G PMS1 USP13 17148452 biogrid exp, ortho GP GP G G GP GP G G GP G GP GP GP GP G GP GP G GP G GP G G GP GP G GP GP G VCP USP13 24424410 biogrid exp, ortho GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP G GP GP G RAD23A USP13 19013454, 23023127 biogrid exp, ortho, pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP G GP GP G USP5 USP13 19615732, 23023127 biogrid,intact exp, ortho, pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP G GP GP G GP GP G USP13 TRIM63 11927605, 21836163 hprd,biogrid exp, ortho, pred G G G G USP13 AMFR 24424410, 23023127 biogrid exp, pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP G GP GP G PARK2 USP13 23023127 pred P GP G P GP G GP GP G GP P P G P GP GP P G P GP GP GP P GP G RAD23B USP13 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP G GP GP G USP13 UBQLN3 23023127 pred G G G G G G GP G UBXN1 USP13 23023127 pred GP GP G G G GP G G GP G GP GP GP GP G GP GP GP GP G GP GP G GP GP G GP GP G UBE4A USP13 23023127 pred GP GP G G G GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP G GP GP G USP13 UBQLN2 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP G GP GP G UBR5 USP13 23023127 pred GP G G G G GP G G GP G GP GP GP GP G G GP G G G GP G G G G G GP GP G USP13 USP25 16082366 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP G GP GP G USP13 YIPF1 21836163 pred GP GP G G GP G G GP G G GP GP GP G G G G G G G G GP GP G G G GP G G USP13 NUB1 23023127 pred GP GP G G GP G G GP GP G GP GP GP GP G GP G GP GP G GP GP G GP GP G GP GP G CBLB USP13 23023127 pred GP GP G G G GP G G GP G GP GP GP GP G GP GP GP GP G GP GP G G GP G GP GP G UBXN2B USP13 23023127 pred G GP G G G G G G GP G GP G GP G G GP G GP G G G GP G G GP G GP GP G USP13 FAF1 23023127 pred GP GP G G GP GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP GP GP G GP GP G LATS1 USP13 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP G GP GP G UBC USP13 23023127 pred AXIN1 USP13 23023127 pred GP GP G GP GP G P GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP G GP GP G G3BP1 USP13 16082366 pred GP GP G G GP GP G G GP G GP G GP GP G GP GP GP GP G GP GP GP GP GP G GP GP G USP13 UBL7 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP G GP G GP GP G USP14 USP13 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP G GP GP G SQSTM1 USP13 23023127 pred GP GP G G GP G G G GP G GP GP GP GP G GP G GP GP G GP GP GP GP GP G GP GP G USP13 UBQLN1 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP G GP GP G USP13 TDRD3 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G P GP GP GP GP G GP GP SUMO2 USP13 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP G GP GP G UBTD2 USP13 23023127 pred GP GP G G GP GP G GP GP G GP G GP GP G GP GP G GP G GP GP GP GP GP G GP GP G SUMO1 USP13 23023127 pred GP GP G G GP GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP GP GP G GP GP G NEDD4 USP13 23023127 pred GP GP G GP P G GP GP GP G GP GP G GP GP GP GP G GP GP GP GP GP G GP P G USP13 UHRF2 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP G GP GP G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants P11441 Q92995 affinity chromatography technology 19615732 physical association X 2 A0A024R8R4 Q92995 affinity chromatography technology 19615732 physical association X 2 F6KD01 Q92995 affinity chromatography technology 24270891 physical association X 2 F6KD01 Q92995 affinity chromatography technology 24270891 physical association X 2 F6KD01 Q92995 pull down 24270891 direct interaction X 2 F6KD01 Q92995 enzymatic study 24270891 direct interaction X 2 A0A024R6T1 Q92995 affinity chromatography technology 19615732 physical association X 2 Q96J02-2 Q92995 affinity chromatography technology 19615732 physical association X 2 A0A024R332 Q92995 biochemical 22939629 colocalization X 2 A0A024R6C9 Q92995 affinity chromatography technology 19615732 physical association X 2 Q14683 Q92995 affinity chromatography technology 19615732 physical association X 2 Q13309-2 Q92995 affinity chromatography technology 21571647 physical association X 2 A0A024RBJ2 Q92995 affinity chromatography technology 19615732 physical association X 2 P42224-2 Q92995 affinity chromatography technology 23940278 physical association X 2 P42224-2 Q92995 affinity chromatography technology 23940278 physical association X 2 Q92995 Q9BYC9 two hybrid 16169070 direct interaction X 2 Q92995 A0A024RBT2 affinity chromatography technology 19615732 physical association X 2 Q92995 I6L9H5 affinity chromatography technology 17148452 physical association X 2 P45974-2 Q92995 affinity chromatography technology 19615732 physical association X 2 Q9UQE7 Q92995 affinity chromatography technology 19615732 physical association X 2 Q15386 Q92995 biochemical 22939629 colocalization X 2 A0A024R7G8 Q92995 affinity chromatography technology 19013454 physical association X 2 Q9BWH2 Q92995 two hybrid 16169070 direct interaction X 2 Q96FV9 Q92995 biochemical 22939629 colocalization X 2 Q9UKN7 Q92995 two hybrid 16169070 direct interaction X 2 Q13571 Q92995 two hybrid 15231748 direct interaction X 2 Q969Q1 Q92995 two hybrid 11927605 direct interaction X 2 Q96CS3 Q92995 affinity chromatography technology 19615732 physical association X 2 O43255 Q92995 affinity chromatography technology 21659512 physical association X 2 O43255 Q92995 pull down 21659512 direct interaction X 2 P0CG48 Q92995 affinity chromatography technology 22053931 physical association X 2 P0CG48 Q92995 affinity chromatography technology 22505724 physical association X 2 P0CG48 Q92995 pull down 23314748 direct interaction X 2 P0CG48 Q92995 affinity chromatography technology 23000965 physical association X 2 P0CG48 Q92995 affinity chromatography technology 24816145 physical association X 2 P0CG48 Q92995 affinity chromatography technology 25147182 physical association X 2 P0CG48 Q92995 pull down 22216260 direct interaction X 2 P0CG48 Q92995 enzymatic study 22216260 direct interaction X 2 P0CG48 Q92995 affinity chromatography technology 21987572 physical association X 2 P0CG48 Q92995 affinity chromatography technology 20972266 physical association X 2 P0CG48 Q92995 affinity chromatography technology 21963094 physical association X 2 P0CG48 Q92995 affinity chromatography technology 21139048 physical association X 2 P0CG48 Q92995 affinity chromatography technology 21890473 physical association X 2 P0CG48 Q92995 affinity chromatography technology 21906983 physical association X 2 Q92995 O14640-2 two hybrid 16169070 direct interaction X 2 Q92995 Q5T0N5 two hybrid 16169070 direct interaction X 2 Q92995 Q15843 affinity chromatography technology 19615732 physical association X 2 Q92995 Q02218-2 affinity chromatography technology 19615732 physical association X 2 Q92995 affinity chromatography technology 19615732 physical association X 2 Q92995 C9JQV6 affinity chromatography technology 19615732 physical association X 2 Q92995 Q9Y4C2-2 affinity chromatography technology 19615732 physical association X 2 Q92995 Q9HB71-2 affinity chromatography technology 19615732 physical association X 2 Q92995 Q9Y597 affinity chromatography technology 19615732 physical association X 2 Q92995 affinity chromatography technology 21571647 physical association X 2 Q9BYV6-4 Q92995 two hybrid 11927605 direct interaction X 2 Q5T0N5-3 Q92995 two hybrid 16169070 - X 2 Q5T0N5-3 Q92995 two hybrid 16169070 - X 2 Q92995 Q9BYC9 two hybrid 16169070 - X 2 Q92995 Q9BYC9 two hybrid 16169070 - X 2 Q9BWH2 Q92995 two hybrid 16169070 - X 2 Q9BWH2 Q92995 two hybrid 16169070 - X 2 Q9UKN7 Q92995 two hybrid 16169070 - X 2 Q9UKN7 Q92995 two hybrid 16169070 - X 2 Q13571 Q92995 two hybrid 15231748 - X 2 Q13571 Q92995 two hybrid 15231748 - X 2 Q969Q1 Q92995 two hybrid 11927605 - X 2 Q969Q1 Q92995 in vitro 11927605 - X 2 Q969Q1 Q92995 two hybrid 11927605 - X 2 Q969Q1 Q92995 in vitro 11927605 - X 2 Q92995 O14640-2 two hybrid 16169070 - X 2 Q92995 O14640-2 two hybrid 16169070 - X 2 Q9BYV6-4 Q92995 two hybrid 11927605 - X 2 Q9BYV6-4 Q92995 two hybrid 11927605 - X 2 Q92995 anti tag coimmunoprecipitation 19615732 physical association C 4 P22532 Q92995 two hybrid pooling approach 16169070 physical association X 2 Q92995 Q9BYC9 two hybrid pooling approach 16169070 physical association X 2 Q92995 anti tag coimmunoprecipitation 19615732 physical association C 18 O14640 Q92995 two hybrid pooling approach 16169070 physical association X 2 Q9BWH2 Q92995 two hybrid pooling approach 16169070 physical association X 2 Q9UKN7 Q92995 two hybrid pooling approach 16169070 physical association X 2 Q13571 Q92995 two hybrid 15231748 physical association X 2 Q9UN81 Q92995 two hybrid pooling approach 16169070 physical association X 2 Q92995 Q5T0N5 two hybrid pooling approach 16169070 physical association X 2 P45974 Q92995 anti tag coimmunoprecipitation 19615732 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B STAT1 USP13 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 23940278 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_297113|BIOGRID_297112 prey|bait bait|prey SPRR2C USP13 MI:0018(two hybrid)|MI:0018(two hybrid) 16169070 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) MI:0471(mint)|MI:0471(mint) MINT_64474|MINT_35446 prey|prey bait|bait THOC7 USP13 MI:0401(biochemical) 22939629 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_236449 bait prey PTEN USP13 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 24270891 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid)|(biogrid) BIOGRID_310059|BIOGRID_310054|BIOGRID_310061|BIOGRID_310052 bait|bait|prey|prey prey|prey|bait|bait USP13 FAM115A MI:0007(anti tag coimmunoprecipitation)|MI:0004(affinity chromatography technology) 19615732 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (intact)|(biogrid) UniProt_100660|BIOGRID_120093 bait|bait prey|prey USP13 KCTD3 MI:0007(anti tag coimmunoprecipitation)|MI:0004(affinity chromatography technology) 19615732 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (intact)|(biogrid) UniProt_100660|BIOGRID_120437 bait|bait prey|prey FNBP1L USP13 MI:0018(two hybrid)|MI:0492(in vitro)|MI:0018(two hybrid)|MI:0007(anti tag coimmunoprecipitation)|MI:0018(two hybrid) 16169070 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|-|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|MI:0468(hprd)|MI:0471(mint)|(intact)|MI:0471(mint) BIOGRID_95476|HPRD_22240|MINT_35451|UniProt_155008|MINT_64479 prey|-|prey|prey|prey bait|-|bait|bait|bait UBE3C USP13 MI:0401(biochemical) 22939629 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_241995 bait prey SIAH2 USP13 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 21659512 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (biogrid)|(biogrid) BIOGRID_141421|BIOGRID_141422 bait|bait prey|prey USP13 CYLD MI:0007(anti tag coimmunoprecipitation)|MI:0004(affinity chromatography technology) 19615732 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (intact)|(biogrid) UniProt_100660|BIOGRID_119428 bait|bait prey|prey USP13 DIABLO MI:0007(anti tag coimmunoprecipitation)|MI:0004(affinity chromatography technology) 19615732 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (intact)|(biogrid) UniProt_100660|BIOGRID_120581 bait|bait prey|prey USP13 THOC1 MI:0401(biochemical) 22939629 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_241857 prey bait DVL1 USP13 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0492(in vitro)|MI:0007(anti tag coimmunoprecipitation)|MI:0018(two hybrid) 16169070 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|-|MI:0915(physical association)|MI:0407(direct interaction) MI:0471(mint)|MI:0471(mint)|MI:0468(hprd)|(intact)|(biogrid) MINT_64475|MINT_35447|HPRD_28865|UniProt_156669|BIOGRID_94094 prey|prey|-|prey|prey bait|bait|-|bait|bait USP13 FAF2 MI:0007(anti tag coimmunoprecipitation)|MI:0004(affinity chromatography technology) 19615732 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (intact)|(biogrid) UniProt_100660|BIOGRID_120288 bait|bait prey|prey USP13 ITCH MI:0007(anti tag coimmunoprecipitation)|MI:0004(affinity chromatography technology) 19615732 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (intact)|(biogrid) UniProt_100660|BIOGRID_120705 bait|bait prey|prey USP13 TRIM63 MI:0493(in vivo)|MI:0018(two hybrid) 11927605 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) -|MI:0407(direct interaction) MI:0468(hprd)|(biogrid) HPRD_12533|BIOGRID_102445 -|bait -|prey USP13 CACYBP MI:0007(anti tag coimmunoprecipitation)|MI:0004(affinity chromatography technology) 19615732 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (intact)|(biogrid) UniProt_100660|BIOGRID_120392 bait|bait prey|prey USP13 NPLOC4 MI:0007(anti tag coimmunoprecipitation)|MI:0004(affinity chromatography technology) 19615732 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (intact)|(biogrid) UniProt_100660|BIOGRID_120545 bait|bait prey|prey USP5 USP13 MI:0004(affinity chromatography technology)|MI:0007(anti tag coimmunoprecipitation) 19615732 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_119998|UniProt_100683 bait|bait prey|prey LAPTM5 USP13 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 15231748 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|-|MI:0915(physical association) (biogrid)|(intact)|MI:0471(mint)|MI:0468(hprd)|MI:0471(mint) BIOGRID_259137|UniProt_79182|MINT_61516|HPRD_2805|MINT_32668 bait|bait|bait|-|bait prey|prey|prey|-|prey USP13 KCTD10 MI:0007(anti tag coimmunoprecipitation)|MI:0004(affinity chromatography technology) 19615732 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (intact)|(biogrid) UniProt_100660|BIOGRID_120710 bait|bait prey|prey USP13 SMC3 MI:0007(anti tag coimmunoprecipitation)|MI:0004(affinity chromatography technology) 19615732 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (intact)|(biogrid) UniProt_100660|BIOGRID_120012 bait|bait prey|prey UFD1L USP13 MI:0007(anti tag coimmunoprecipitation)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 19615732,21571647 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (intact)|(biogrid)|(biogrid) UniProt_100660|BIOGRID_142177|BIOGRID_119841 prey|bait|prey bait|prey|bait UBL4A USP13 MI:0007(anti tag coimmunoprecipitation)|MI:0004(affinity chromatography technology) 19615732 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (intact)|(biogrid) UniProt_100660|BIOGRID_119902 prey|prey bait|bait SMC1A USP13 MI:0007(anti tag coimmunoprecipitation)|MI:0004(affinity chromatography technology) 19615732 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (intact)|(biogrid) UniProt_100660|BIOGRID_119900 prey|prey bait|bait DKFZp686N18198 USP13 MI:0018(two hybrid)|MI:0018(two hybrid) 16169070 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) MI:0471(mint)|MI:0471(mint) MINT_35448|MINT_64476 prey|prey bait|bait USP13 TRIM55 MI:0493(in vivo)|MI:0018(two hybrid) 11927605 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) -|MI:0407(direct interaction) MI:0468(hprd)|(biogrid) HPRD_12534|BIOGRID_102444 -|bait -|prey USP13 MRPL20 MI:0018(two hybrid)|MI:0492(in vitro)|MI:0018(two hybrid)|MI:0007(anti tag coimmunoprecipitation)|MI:0018(two hybrid) 16169070 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|-|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association) MI:0471(mint)|MI:0468(hprd)|(biogrid)|(intact)|MI:0471(mint) MINT_35449|HPRD_22241|BIOGRID_95475|UniProt_155007|MINT_64477 bait|-|bait|bait|bait prey|-|prey|prey|prey RAD23A USP13 MI:0415(enzymatic study) 19013454 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_188743 bait prey ATXN3 USP13 MI:0007(anti tag coimmunoprecipitation)|MI:0004(affinity chromatography technology) 19615732 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (intact)|(biogrid) UniProt_100629|BIOGRID_119997 bait|bait prey|prey SPRR2D USP13 MI:0007(anti tag coimmunoprecipitation) 16169070 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (intact) UniProt_156672 prey bait OGDH USP13 MI:0007(anti tag coimmunoprecipitation)|MI:0004(affinity chromatography technology) 19615732 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (intact)|(biogrid) UniProt_100660|BIOGRID_119628 prey|prey bait|bait NEDD8 USP13 MI:0007(anti tag coimmunoprecipitation)|MI:0004(affinity chromatography technology) 19615732 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (intact)|(biogrid) UniProt_100660|BIOGRID_119614 prey|prey bait|bait ETS1 USP13 MI:0492(in vitro) 16169070 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) - MI:0468(hprd) HPRD_28455 - - PMS1 USP13 MI:0004(affinity chromatography technology) 17148452 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_122103 bait prey SKP2 USP13 MI:0004(affinity chromatography technology) 21571647 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_142180 bait prey DLST USP13 MI:0004(affinity chromatography technology) 19615732 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_119440 prey bait USP13 MYO15A MI:0018(two hybrid)|MI:0492(in vitro)|MI:0007(anti tag coimmunoprecipitation) 16169070 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|-|MI:0915(physical association) (biogrid)|MI:0468(hprd)|(intact) BIOGRID_94918|HPRD_29292|UniProt_155862 bait|-|bait prey|-|prey USP13 L1RE1 MI:0007(anti tag coimmunoprecipitation) 16169070 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (intact) UniProt_156671 bait prey UBC USP13 MI:0004(affinity chromatography technology)|MI:0096(pull down)|MI:0096(pull down)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0415(enzymatic study)|MI:0004(affinity chromatography technology)|MI:0096(pull down)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 20972266,21139048,21890473,21906983,21963094,21987572,22053931,22216260,22505724,23000965,23314748 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid) BIOGRID_225432|BIOGRID_160895|BIOGRID_160896|BIOGRID_164287|BIOGRID_173581|BIOGRID_179730|BIOGRID_170497|BIOGRID_163965|BIOGRID_222161|BIOGRID_247923|BIOGRID_166494|BIOGRID_268718 bait|bait|prey|bait|bait|bait|bait|bait|bait|bait|bait|bait prey|prey|bait|prey|prey|prey|prey|prey|prey|prey|prey|prey USP13 FUNDC2 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0492(in vitro)|MI:0007(anti tag coimmunoprecipitation)|MI:0018(two hybrid) 16169070 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction)|-|MI:0915(physical association)|MI:0915(physical association) MI:0471(mint)|(biogrid)|MI:0468(hprd)|(intact)|MI:0471(mint) MINT_35450|BIOGRID_94095|HPRD_29293|UniProt_156670|MINT_64478 bait|bait|-|bait|bait prey|prey|-|prey|prey

PPI - HINT Gene A Gene B PMID Method Quality SYNCRIP USP13 26496610 0007 HT UBC USP13 20972266,21963094,23314748,22216260,22216260 0004,0004,0096,0096,0415 LC UBL4A USP13 24424410,19615732,19615732,24424410,24424410 0004,0004,0007,0415,0096 LC,HT DLST USP13 19615732,19615732 0004,0007 HT USP5 USP13 19615732,19615732 0004,0007 HT BAG6 USP13 24424410,24424410,19615732 0004,0096,0007 LC,HT ATXN3 USP13 19615732,19615732 0004,0007 HT PTEN USP13 26453058,24270891,24270891,24270891,26453058 0004,0096,0415,0004,0428 LC OGDH USP13 19615732,19615732 0004,0007 HT SMC1A USP13 26496610,19615732,19615732,26496610 0007,0004,0007,0004 HT UBE3C USP13 22939629 0401 HT NEDD8 USP13 19615732,19615732 0004,0007 HT Q59GL1 USP13 26496610 0004 HT THOC7 USP13 22939629 0401 HT SCCPDH USP13 26186194 0004 HT NPLOC4 USP13 19615732,19615732 0004,0007 HT UFD1L USP13 19615732,19615732,21571647 0004,0007,0004 HT,LC USP13 FAF2 19615732,19615732 0004,0007 HT USP13 THOC1 22939629 0401 HT USP13 ITCH 19615732,19615732 0004,0007 HT USP13 RPP25 26186194 0004 HT USP13 KCTD10 19615732,19615732 0004,0007 HT USP13 CACYBP 19615732,19615732 0004,0007 HT USP13 CYLD 19615732,19615732 0004,0007 HT USP13 DIABLO 19615732,19615732 0004,0007 HT USP13 SMC3 26496610,19615732,19615732,26496610 0007,0004,0007,0004 HT USP13 TCAF1 19615732,19615732 0004,0007 HT USP13 KCTD3 19615732,19615732 0004,0007 HT USP13 YTHDF2 26344197 0401 HT SYNCRIP USP13 26496610 0007 HT UBL4A USP13 19615732,19615732 0004,0007 HT DLST USP13 19615732,19615732 0004,0007 HT USP5 USP13 19615732,19615732 0004,0007 HT BAG6 USP13 19615732 0007 HT ATXN3 USP13 19615732,19615732 0004,0007 HT OGDH USP13 19615732,19615732 0004,0007 HT SMC1A USP13 26496610,19615732,19615732,26496610 0007,0004,0007,0004 HT UBE3C USP13 22939629 0401 HT NEDD8 USP13 19615732,19615732 0004,0007 HT Q59GL1 USP13 26496610 0004 HT THOC7 USP13 22939629 0401 HT SCCPDH USP13 26186194 0004 HT NPLOC4 USP13 19615732,19615732 0004,0007 HT UFD1L USP13 19615732,19615732 0004,0007 HT USP13 FAF2 19615732,19615732 0004,0007 HT USP13 THOC1 22939629 0401 HT USP13 ITCH 19615732,19615732 0004,0007 HT USP13 RPP25 26186194 0004 HT USP13 KCTD10 19615732,19615732 0004,0007 HT USP13 CACYBP 19615732,19615732 0004,0007 HT USP13 CYLD 19615732,19615732 0004,0007 HT USP13 DIABLO 19615732,19615732 0004,0007 HT USP13 SMC3 26496610,19615732,19615732,26496610 0007,0004,0007,0004 HT USP13 TCAF1 19615732,19615732 0004,0007 HT USP13 KCTD3 19615732,19615732 0004,0007 HT USP13 YTHDF2 26344197 0401 HT UBC USP13 20972266,21963094,23314748,22216260,22216260 0004,0004,0096,0096,0415 LC UBL4A USP13 24424410,24424410,24424410 0004,0415,0096 LC BAG6 USP13 24424410,24424410 0004,0096 LC PTEN USP13 26453058,24270891,24270891,24270891,26453058 0004,0096,0415,0004,0428 LC UFD1L USP13 21571647 0004 LC DVL1 USP13 16169070,16169070 0018,0398 HT UBC USP13 22216260,22216260 0096,0415 LC UBL4A USP13 24424410,24424410,24424410 0004,0415,0096 LC SPRR2D USP13 16169070 0398 HT PTEN USP13 24270891,24270891,24270891,26280536 0096,0415,0004,0415 LC LAPTM5 USP13 15231748 0018 HT UBE3C USP13 22939629 0401 LC Q15515 USP13 16169070 0018 HT FNBP1L USP13 16169070,16169070 0018,0398 HT THOC7 USP13 22939629 0401 LC DKFZP686N18198 USP13 16169070 0018 HT USP13 TRIM63 11927605 0018 LC USP13 THOC1 22939629 0401 LC USP13 FUNDC2 16169070,16169070 0018,0398 HT USP13 MRPL20 16169070,16169070 0018,0398 HT USP13 TRIM55 11927605 0018 LC USP13 MYO15A 16169070,16169070 0018,0398 HT USP13 L1RE1 16169070 0398 HT USP13 YTHDF2 26344197 0401 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q92995 P22532 USP13 SPRR2D 0.126 16169070 Q9HCE1 Q92995 MOV10 USP13 0.126 22658674 Q92995 Q8NBX0 USP13 SCCPDH 0.126 26186194 Q92995 Q6I9Y2 USP13 THOC7 0.081 22939629 Q92995 P11441 USP13 UBL4A 0.712 24424410,19615732 Q9UQE7 Q92995 SMC3 USP13 0.416 26496610,19615732 Q96J02 Q92995 ITCH USP13 0.236 19615732 Q92995 P55072 USP13 VCP 0.454 24424410 Q92995 P36957 USP13 DLST 0.236 19615732 Q96CS3 Q92995 FAF2 USP13 0.236 19615732 Q92995 Q14683 USP13 SMC1A 0.416 26496610,19615732 Q92995 Q02218 USP13 OGDH 0.236 19615732 Q92995 Q15843 USP13 NEDD8 0.236 19615732 Q92995 Q8TAT6 USP13 NPLOC4 0.236 19615732 Q9Y4C2 Q92995 FAM115A USP13 0.236 19615732 Q9HB71 Q92995 CACYBP USP13 0.236 19615732 Q9H3F6 Q92995 KCTD10 USP13 0.236 19615732 Q9NQC7 Q92995 CYLD USP13 0.236 19615732 Q9NR28 Q92995 DIABLO USP13 0.236 19615732 Q9Y597 Q92995 KCTD3 USP13 0.236 19615732 Q92995 Q13571 USP13 LAPTM5 0.332 15231748 Q92995 Q15038 USP13 DAZAP2 0.236 unassigned1304 Q9CU62 Q92995 SMC1A USP13 0.236 26496610 Q9CW03 Q92995 SMC3 USP13 0.236 26496610 Q92995 P45974 USP13 USP5 0.236 19615732 Q92995 O43255 USP13 SIAH2 0.454 21659512 Q92995 P54252 USP13 ATXN3 0.236 19615732 Q92995 O60506 USP13 SYNCRIP 0.236 26496610 Q92995 P60484 USP13 PTEN 0.888 26453058,24270891,26280536 Q92995 Q92890 USP13 UFD1L 0.396 19615732,21571647 Q92995 O14640 USP13 DVL1 0.286 16169070 Q92995 P0CG48 USP13 UBC 0.436 23314748,22216260 Q92995 P42224 USP13 STAT1 0.376 23940278 Q92995 Q5T0N5 USP13 FNBP1L 0.286 16169070 Q92995 Q7L5D6 USP13 GET4 0.21 24424410 Q969Q1 Q92995 TRIM63 USP13 0.309 11927605 Q9BWH2 Q92995 FUNDC2 USP13 0.286 16169070 Q9BYC9 Q92995 MRPL20 USP13 0.286 16169070 Q9BYV6 Q92995 TRIM55 USP13 0.309 11927605 Q9UKN7 Q92995 MYO15A USP13 0.286 16169070 Q9UKV5 Q92995 AMFR USP13 0.569 24424410 Q9Y5A9 Q92995 YTHDF2 USP13 0.081 26344197 Q96FV9 Q92995 THOC1 USP13 0.081 22939629 Q9BUL9 Q92995 RPP25 USP13 0.126 26186194 Q9UN81 Q92995 L1RE1 USP13 0.126 16169070 Q92995 P46379 USP13 BAG6 0.671 24424410,19615732 Q92995 Q13309 USP13 SKP2 0.21 21571647 Q92995 Q15386 USP13 UBE3C 0.081 22939629 Q92995 P54277 USP13 PMS1 0.126 17148452 Q92995 P54725 USP13 RAD23A 0.126 19013454

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 EIF3CL USP13 MI:0362 inference MI:0461 interaction database PSMD14 USP13 MI:0362 inference MI:0461 interaction database FBP2 USP13 MI:0362 inference MI:0461 interaction database DVL1 USP13 MI:0045 experimental interaction detection MI:0461 interaction database DDX3Y USP13 MI:0362 inference MI:0461 interaction database SIAH2 USP13 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database SYNCRIP USP13 MI:0045 experimental interaction detection MI:0461 interaction database EED USP13 MI:0362 inference MI:0461 interaction database PGLS USP13 MI:0362 inference MI:0461 interaction database MOCS3 USP13 MI:0362 inference MI:0461 interaction database ISG15 USP13 MI:0362 inference MI:0461 interaction database RPLP0 USP13 MI:0362 inference MI:0461 interaction database MYL1 USP13 MI:0362 inference MI:0461 interaction database FBP1 USP13 MI:0362 inference MI:0461 interaction database UBC USP13 MI:0045 experimental interaction detection MI:0461 interaction database HSPA1B USP13 MI:0362 inference MI:0461 interaction database HSPA8 USP13 MI:0362 inference MI:0461 interaction database TOP1 USP13 MI:0362 inference MI:0461 interaction database UBL4A USP13 MI:0045 experimental interaction detection MI:0461 interaction database PABPC1 USP13 MI:0362 inference MI:0461 interaction database ATP6V1B1 USP13 MI:0362 inference MI:0461 interaction database HSPA6 USP13 MI:0362 inference MI:0461 interaction database ATP6V1B2 USP13 MI:0362 inference MI:0461 interaction database GPD1 USP13 MI:0362 inference MI:0461 interaction database SPRR2D USP13 MI:0045 experimental interaction detection MI:0461 interaction database HSPA1L USP13 MI:0362 inference MI:0461 interaction database RPL4 USP13 MI:0362 inference MI:0461 interaction database DLST USP13 MI:0045 experimental interaction detection MI:0461 interaction database IARS USP13 MI:0362 inference MI:0461 interaction database STAT1 USP13 MI:0045 experimental interaction detection MI:0461 interaction database USP5 USP13 MI:0045 experimental interaction detection MI:0461 interaction database BAG6 USP13 MI:0045 experimental interaction detection MI:0461 interaction database RPL5 USP13 MI:0362 inference MI:0461 interaction database MTNR1A USP13 MI:0362 inference MI:0461 interaction database IST1 USP13 MI:0362 inference MI:0461 interaction database ATXN3 USP13 MI:0045 experimental interaction detection MI:0461 interaction database PMS1 USP13 MI:0045 experimental interaction detection MI:0461 interaction database HSPA2 USP13 MI:0362 inference MI:0461 interaction database RAD23A USP13 MI:0045 experimental interaction detection MI:0461 interaction database VCP USP13 MI:0045 experimental interaction detection MI:0461 interaction database PTEN USP13 MI:0045 experimental interaction detection MI:0461 interaction database RPS27A USP13 MI:0362 inference MI:0461 interaction database UBA52 USP13 MI:0362 inference MI:0461 interaction database OGDH USP13 MI:0045 experimental interaction detection MI:0461 interaction database SKP2 USP13 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database PABPC4 USP13 MI:0362 inference MI:0461 interaction database LAPTM5 USP13 MI:0045 experimental interaction detection MI:0461 interaction database BECN1 USP13 MI:0362 inference MI:1106 pathways database SMC1A USP13 MI:0045 experimental interaction detection MI:0461 interaction database USP10 USP13 MI:0362 inference MI:1106 pathways database NEDD8 USP13 MI:0045 experimental interaction detection MI:0461 interaction database PABPC1L USP13 MI:0362 inference MI:0461 interaction database PABPC1L2A USP13 MI:0362 inference MI:0461 interaction database FNBP1L USP13 MI:0045 experimental interaction detection MI:0461 interaction database GET4 USP13 MI:0045 experimental interaction detection MI:0461 interaction database GPD1L USP13 MI:0362 inference MI:0461 interaction database SCCPDH USP13 MI:0045 experimental interaction detection MI:0461 interaction database NPLOC4 USP13 MI:0045 experimental interaction detection MI:0461 interaction database LEO1 USP13 MI:0362 inference MI:0461 interaction database RAD54L USP13 MI:0362 inference MI:0461 interaction database UFD1L USP13 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database USP13 USP7 MI:0362 inference MI:0461 interaction database USP13 TOP1MT MI:0362 inference MI:0461 interaction database USP13 TRIM63 MI:0045 experimental interaction detection MI:0461 interaction database USP13 FAF2 MI:0045 experimental interaction detection MI:0461 interaction database USP13 PABPC5 MI:0362 inference MI:0461 interaction database USP13 ITCH MI:0045 experimental interaction detection MI:0461 interaction database USP13 EIF3C MI:0362 inference MI:0461 interaction database USP13 RPP25 MI:0045 experimental interaction detection MI:0461 interaction database USP13 FUNDC2 MI:0045 experimental interaction detection MI:0461 interaction database USP13 MRPL20 MI:0045 experimental interaction detection MI:0461 interaction database USP13 TRIM55 MI:0045 experimental interaction detection MI:0461 interaction database USP13 PABPC3 MI:0362 inference MI:0461 interaction database USP13 KCTD10 MI:0045 experimental interaction detection MI:0461 interaction database USP13 CACYBP MI:0045 experimental interaction detection MI:0461 interaction database USP13 MOV10 MI:0045 experimental interaction detection MI:0461 interaction database USP13 CYLD MI:0045 experimental interaction detection MI:0461 interaction database USP13 DIABLO MI:0045 experimental interaction detection MI:0461 interaction database USP13 MYO15A MI:0045 experimental interaction detection MI:0461 interaction database USP13 AMFR MI:0045 experimental interaction detection MI:0461 interaction database USP13 L1RE1 MI:0045 experimental interaction detection MI:0461 interaction database USP13 SMC3 MI:0045 experimental interaction detection MI:0461 interaction database USP13 TCAF1 MI:0045 experimental interaction detection MI:0461 interaction database USP13 KCTD3 MI:0045 experimental interaction detection MI:0461 interaction database