PTM - CPLM Gene Name UniProt ID Type Position Code USP13; ISOT3 Q92995 Ubiquitination 640 K USP13; ISOT3 Q92995 Ubiquitination 190 K USP13; ISOT3 Q92995 Ubiquitination 328 K USP13; ISOT3 Q92995 Ubiquitination 597 K USP13; ISOT3 Q92995 Ubiquitination 259 K USP13; ISOT3 Q92995 Ubiquitination 18 K USP13; ISOT3 Q92995 Ubiquitination 430 K USP13; ISOT3 Q92995 Ubiquitination 587 K USP13; ISOT3 Q92995 Ubiquitination 598 K USP13; ISOT3 Q92995 Ubiquitination 401 K USP13; ISOT3 Q92995 Ubiquitination 435 K USP13; ISOT3 Q92995 Ubiquitination 389 K USP13; ISOT3 Q92995 Ubiquitination 565 K USP13; ISOT3 Q92995 Ubiquitination 850 K USP13; ISOT3 Q92995 Ubiquitination 326 K USP13; ISOT3 Q92995 Ubiquitination 841 K USP13; ISOT3 Q92995 Ubiquitination 176 K USP13; ISOT3 Q92995 Ubiquitination 586 K USP13; ISOT3 Q92995 Ubiquitination 511 K

PTM - dbPAF Gene Name UniProt ID Position Type Species USP13; ISOT3 Q92995 104 S Homo sapiens(Human) USP13; ISOT3 Q92995 114 S Homo sapiens(Human) USP13; ISOT3 Q92995 122 T Homo sapiens(Human) USP13; ISOT3 Q92995 128 S Homo sapiens(Human) USP13; ISOT3 Q92995 14 S Homo sapiens(Human) USP13; ISOT3 Q92995 181 T Homo sapiens(Human) USP13; ISOT3 Q92995 228 S Homo sapiens(Human) USP13; ISOT3 Q92995 34 T Homo sapiens(Human) USP13; ISOT3 Q92995 380 T Homo sapiens(Human) USP13; ISOT3 Q92995 385 T Homo sapiens(Human) USP13; ISOT3 Q92995 388 T Homo sapiens(Human) USP13; ISOT3 Q92995 396 S Homo sapiens(Human) USP13; ISOT3 Q92995 399 Y Homo sapiens(Human) USP13; ISOT3 Q92995 425 S Homo sapiens(Human) USP13; ISOT3 Q92995 53 Y Homo sapiens(Human) USP13; ISOT3 Q92995 63 Y Homo sapiens(Human) USP13; ISOT3 Q92995 630 S Homo sapiens(Human)

PTM - PhosphositePlus UniProt ID MOD_RSD Type SITE_+/-7_AA Q92995 R4-m1 Methylation ____MQRrGALFGMP Q92995 R101-m1 Methylation RHVREKVrGAsGGAL Q92995 S14-p Phosphorylation LFGMPGGsGGRkMAA Q92995 T34-p Phosphorylation LLVPHMPtIRVPRSG Q92995 S104-p Phosphorylation REKVrGAsGGALPKR Q92995 S114-p Phosphorylation ALPKRRNsKIFLDLD Q92995 T122-p Phosphorylation KIFLDLDtDDDLNsD Q92995 S128-p Phosphorylation DtDDDLNsDDYEYED Q92995 T181-p Phosphorylation YRkQDPDtWENELPV Q92995 T380-p Phosphorylation DYSPLDPtQDFNtQM Q92995 T385-p Phosphorylation DPtQDFNtQMtKLGH Q92995 T388-p Phosphorylation QDFNtQMtKLGHGLL Q92995 S396-p Phosphorylation KLGHGLLsGQySkPP Q92995 Y399-p Phosphorylation HGLLsGQySkPPVkS Q92995 S425-p Phosphorylation KPQQNGIsPRMFkAF Q92995 S630-p Phosphorylation EEELPDIsPPIVIPD Q92995 K405-sm Sumoylation QySkPPVkSELIEQV Q92995 K18-ub Ubiquitination PGGsGGRkMAAGDIG Q92995 K176-ub Ubiquitination SSKSPYRkQDPDtWE Q92995 K190-ub Ubiquitination ENELPVSkYANNLTQ Q92995 K259-ub Ubiquitination MGYPLAVkLGTITPD Q92995 K326-ub Ubiquitination VIQESGTkLkPMYGP Q92995 K328-ub Ubiquitination QESGTkLkPMYGPGY Q92995 K339-ub Ubiquitination GPGYTGLkNLGNSCY Q92995 K401-ub Ubiquitination LLsGQySkPPVkSEL Q92995 K405-ub Ubiquitination QySkPPVkSELIEQV Q92995 K430-ub Ubiquitination GIsPRMFkAFVSkSH Q92995 K435-ub Ubiquitination MFkAFVSkSHPEFSS Q92995 K511-ub Ubiquitination AMEAATNkDELIAYE Q92995 K586-ub Ubiquitination EYLVVQIkkFTFGLD Q92995 K587-ub Ubiquitination YLVVQIkkFTFGLDW Q92995 K597-ub Ubiquitination FGLDWVPkKFDVSID Q92995 K640-ub Ubiquitination IVIPDDSkDRLMNQL

PTM - dbPTM UniProt ID Position Code Type Resources References Q92995 114 S Phosphorylation Swiss-Prot 1010711 19690332 Q92995 122 T Phosphorylation Swiss-Prot 1010711 18669648;19690332 Q92995 122 T Phosphorylation PhosphoELM.10011 18669648 Q92995 176 K Ubiquitylation Phosphositeplus.1010730 21906983 Q92995 18 K Ubiquitylation Phosphositeplus.1010730 21906983 Q92995 190 K Ubiquitylation Phosphositeplus.1010730 21890473;21906983 Q92995 259 K Ubiquitylation Phosphositeplus.1010730 21906983 Q92995 326 K Ubiquitylation Phosphositeplus.1010730 21906983 Q92995 328 K Ubiquitylation Phosphositeplus.1010730 21890473;21906983 Q92995 401 K Ubiquitylation Phosphositeplus.1010730 21906983 Q92995 405 K Ubiquitylation Phosphositeplus.1010730 20972266 Q92995 430 K Ubiquitylation Phosphositeplus.1010730 21906983 Q92995 435 K Ubiquitylation Phosphositeplus.1010730 21906983 Q92995 511 K Ubiquitylation Phosphositeplus.1010730 21906983 Q92995 586 K Ubiquitylation Phosphositeplus.1010730 21906983 Q92995 587 K Ubiquitylation Phosphositeplus.1010730 21890473;21906983 Q92995 640 K Ubiquitylation Phosphositeplus.1010730 21906983 Q92995 114 S Phosphorylation Phosphositeplus.1010730 19690332 Q92995 122 T Phosphorylation Phosphositeplus.1010730 18669648;19690332;21406692;22115753 Q92995 53 Y Phosphorylation Phosphositeplus.1010730 18083107 Q92995 63 Y Phosphorylation Phosphositeplus.1010730 18083107 Q92995 228 S Phosphorylation HPRD 9.0 20068231 Q92995 122 T Phosphorylation HPRD 9.0 18669648,18452278 Q92995 122 T Phosphorylation SysPTM 1.1 18669648

PTM - HPRD Symbol Position Code Type References USP13 122 T Phosphorylation 18669648,18452278 USP13 228 S Phosphorylation 20068231

PTM - Phospho.ELM UniProt Position Code PMIDs Kinase Source Type Q92995 122 T 18669648 HTP Phosphorylation

PTM - UniProt UniProt ID Position Type PMIDs Q92995 114 Phosphoserine 19690332 Q92995 122 Phosphothreonine 18669648;19690332;21406692

PTM - BioGRID Entrez Gene BioGRID ID Position Code Type PMIDs 8975 114465 - K Ubiquitination 21987572 8975 114465 - K Ubiquitination 20972266 8975 114465 - K Ubiquitination 21963094 8975 114465 - K Ubiquitination 21139048 8975 114465 - K Ubiquitination 21890473 8975 114465 - K Ubiquitination 21906983 8975 114465 - K Ubiquitination 22053931 8975 114465 - K Ubiquitination 22505724 8975 114465 - K Ubiquitination 23000965 8975 114465 - K Ubiquitination 24816145 8975 114465 - K Ubiquitination 25147182

PTM - mUbiSiDa Gene Name Species Ubiquitination Site Ubiquitination Sequence Evidence PMID USP13 Homo sapiens (Human) 190; 597; 328 "190,NELPVSKYANNLT; 597,GLDWVPKKFDVSI; 328,ESGTKLKPMYGPG" 190:21890473; 597:21890473; 328:21890473 USP13 Homo sapiens (Human) 532; 263; 125 "532,GLDWVPKKFDVSI; 263,ESGTKLKPMYGPG; 125,NELPVSKYANNLT" 532:21890473; 263:21890473; 125:21890473 USP13 Homo sapiens (Human) 243 "243,GLDWVPKKFDVSI" 243:21890473 USP13 Homo sapiens (Human) 511; 586; 587; 401; 435; 640; 405; 326; 259; 18; 597; 190; 430; 176; 328 "511,MEAATNKDELIAY; 586,YLVVQIKKFTFGL; 587,LVVQIKKFTFGLD; 401,LSGQYSKPPVKSE; 435,FKAFVSKSHPEFS; 640,VIPDDSKDRLMNQ; 405,YSKPPVKSELIEQ; 326,IQESGTKLKPMYG; 259,GYPLAVKLGTITP; 18,GGSGGRKMAAGDI; 597,GLDWVPKKFDVSI; 190,NELPVSKYANNLT; 430,ISPRMFKAFVSKS; 176,SKSPYRKQDPDTW; 328,ESGTKLKPMYGPG" "511:21906983; 586:21906983; 587:21906983; 401:21906983; 435:21906983; 640:21906983,21139048,22053931; 405:20972266; 326:21906983; 259:21906983; 18:21906983; 597:21890473,21906983; 190:21890473,21906983; 430:21906983; 176:21906983; 328:21890473,21906983" USP13 Homo sapiens (Human) 148 "148,NELPVSKYANNLT" 148:21890473