PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus EPN2 GTSE1 26496610 biogrid,intact exp P P P EPN2 AP1B1 bci exp EPN2 TMEM17 26638075 biogrid,intact exp P P P P P P EPN2 EPN3 26186194 biogrid exp P P P P P P EPN2 LAPTM5 15231748 hprd,i2d exp P P P P P P P EPN2 YWHAG 15324660 hprd exp P P P P P P P EPN2 RNF11 15231748 hprd,i2d exp P P P P P P P EPN2 UBC 19285159 innatedb,biogrid exp P P P P P P P EPN2 APOE 21163940 biogrid exp P P P P P EPN2 TUBA1B 12750376 hprd,bci exp P P P P P P P EPN2 TFAP2A 10567358 hprd exp P EPN2 RALBP1 20709745 biogrid exp P P P P P P P EPN2 GRB2 20936779 i2d exp P P P P P P P EPN2 EPS15 10567358, 25402006, 21836163 hprd,i2d,bci exp, pred P P P P P P P EPN2 ITSN1 22558309, 25402006 biogrid exp, pred P P P P P P P EPN2 CLTC 10567358, 21836163 hprd,biogrid,bci exp, pred P P P P P P P EPN2 UBQLN2 18199683, 16082366 biogrid exp, pred P P P P P P P EED EPN2 ortho P P P P P P P EPN2 AP2B1 ortho P P P P P P P EPN2 YWHAE ortho P P P P P P P NEURL1 EPN2 ortho P P EPN2 FLT4 ortho EPN2 YWHAB 25402006 ortho, pred P P P P P P P EPN2 TUBA1A 25402006 ortho, pred P P P P P P P STX6 EPN2 23023127 pred P P P P P P P TOM1 EPN2 23023127 pred P P P P P P P PARK2 EPN2 25402006 pred P P P P P P BIN1 EPN2 23023127 pred P P P P P P P AP2A2 EPN2 25402006 pred P P P P P P P SNAP91 EPN2 23023127 pred P P EPN2 CLINT1 23023127 pred P P P P P P P EPN2 AP2A1 25402006 pred P P P P P P P EPN2 STON2 25402006 pred P P P P P P P EPN2 STX1A 23023127 pred P P P P EPN2 PICALM 23023127 pred P P P P P P P AGFG2 EPN2 25402006 pred P P EPN2 MIB1 23023127 pred P P P P P P EPN2 GGA1 23023127 pred P P P P P P P EPN2 EPN1 25402006, 23023127 pred P P P P P P EPN2 REPS2 25402006 pred P P P P P P P EPN2 EPS15L1 25402006 pred P P P P P P P EPN2 AGFG1 25402006 pred P P P P P P P EPN2 AP2M1 25402006 pred P P P P P P P HGS EPN2 25402006 pred P P P P P P

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B EPN2 UBQLN2 MI:0004(affinity chromatography technology) 18199683 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_196825 prey bait EPN2 UBC MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0096(pull down)|MI:0004(affinity chromatography technology) 19285159,21139048,21890473,21906983,21963094,23000965 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid) BIOGRID_267615|BIOGRID_177082|BIOGRID_167659|BIOGRID_263245|BIOGRID_200641|BIOGRID_263961 prey|prey|prey|prey|prey|prey bait|bait|bait|bait|bait|bait EPN2 EPS15 MI:0493(in vivo) 10567358 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) - MI:0468(hprd) HPRD_14163 - - EPN2 APOE MI:0004(affinity chromatography technology) 21163940 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_229987 prey bait EPN2 CLTC MI:0493(in vivo)|MI:0096(pull down) 10567358 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) -|MI:0407(direct interaction) MI:0468(hprd)|(biogrid) HPRD_20054|BIOGRID_114723 -|prey -|bait EPN2 TFAP2A MI:0493(in vivo) 10567358 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) - MI:0468(hprd) HPRD_1130 - - EPN2 YWHAG MI:0493(in vivo) 15324660 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) - MI:0468(hprd) HPRD_26096 - - EPN2 RNF11 MI:0018(two hybrid) 15231748 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) - MI:0468(hprd) HPRD_37820 - - EPN2 ITSN1 MI:0018(two hybrid) 22558309 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_185809 prey bait EPN2 LAPTM5 MI:0018(two hybrid) 15231748 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) - MI:0468(hprd) HPRD_2819 - - EPN2 TUBA1B MI:0492(in vitro) 12750376 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) - MI:0468(hprd) HPRD_20175 - -

PPI - HINT Gene A Gene B PMID Method Quality EPN2 TMEM17 26638075,26638075 1314,1313 HT EPN2 EPN3 26186194 0004 HT EPN2 GTSE1 26496610,26496610 0007,0004 HT EPN2 TMEM17 26638075,26638075 1314,1313 HT EPN2 EPN3 26186194 0004 HT EPN2 GTSE1 26496610,26496610 0007,0004 HT EPN2 APOE 21163940 0018 HT EPN2 EPS15 9303539,9303539 0084,0004 LC EPN2 LAPTM5 15231748 0018 HT EPN2 ITSN1 22558309 0018 HT EPN2 RNF11 15231748 0018 HT

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q60902 O95208 EPS15L1 EPN2 0.309 9303539 Q9H201 O95208 EPN3 EPN2 0.126 26186194 P0CG48 O95208 UBC EPN2 0.309 19285159 P02649 O95208 APOE EPN2 0.183 21163940 Q96QF0 O95208 RAB3IP EPN2 0.126 unassigned1312 P04618 O95208 REV EPN2 0.183 22174317 Q9NYZ3 O95208 GTSE1 EPN2 0.236 26496610 Q8N5I2 O95208 ARRDC1 EPN2 0.236 unassigned1304 Q96C32 O95208 UBC EPN2 0.236 unassigned1304 Q9BWQ8 O95208 FAIM2 EPN2 0.236 unassigned1304 Q12899 O95208 TRIM26 EPN2 0.236 unassigned1304 O95208 O15344 EPN2 MID1 0.236 unassigned1304 O95208 O76064 EPN2 RNF8 0.236 unassigned1304 P36406 O95208 TRIM23 EPN2 0.236 unassigned1304 P40222 O95208 TXLNA EPN2 0.236 unassigned1304 P52888 O95208 THOP1 EPN2 0.236 unassigned1304 P54253 O95208 ATXN1 EPN2 0.236 unassigned1304 P54646 O95208 PRKAA2 EPN2 0.236 unassigned1304 P60228 O95208 EIF3E EPN2 0.236 unassigned1304 Q15038 O95208 DAZAP2 EPN2 0.236 unassigned1304 Q15797 O95208 SMAD1 EPN2 0.236 unassigned1304 Q16655 O95208 MLANA EPN2 0.236 unassigned1304 Q8IYD8 O95208 FANCM EPN2 0.236 unassigned1304 Q8N0X7 O95208 SPG20 EPN2 0.236 unassigned1304 Q8TBH0 O95208 ARRDC2 EPN2 0.236 unassigned1304 Q92567 O95208 FAM168A EPN2 0.236 unassigned1304 Q969T9 O95208 WBP2 EPN2 0.236 unassigned1304 Q969W9 O95208 PMEPA1 EPN2 0.236 unassigned1304 Q96B67 O95208 ARRDC3 EPN2 0.236 unassigned1304 Q96CS7 O95208 PLEKHB2 EPN2 0.236 unassigned1304 Q96G27 O95208 WBP1 EPN2 0.236 unassigned1304 Q99732 O95208 LITAF EPN2 0.236 unassigned1304 Q9BVG3 O95208 TRIM62 EPN2 0.236 unassigned1304 Q9H305 O95208 CDIP1 EPN2 0.236 unassigned1304 Q9NX94 O95208 WBP1L EPN2 0.236 unassigned1304 Q9UJV3 O95208 MID2 EPN2 0.236 unassigned1304 Q86T03 O95208 TMEM55B EPN2 0.236 unassigned1304 Q86X19 O95208 TMEM17 EPN2 0.236 26638075 P62987 O95208 UBA52 EPN2 0.236 unassigned1304 P42567 O95208 EPS15 EPN2 0.523 9303539 Q9UHD9 O95208 UBQLN2 EPN2 0.21 18199683 Q00610 O95208 CLTC EPN2 0.309 10567358 Q15311 O95208 RALBP1 EPN2 0.376 20709745 Q15811 O95208 ITSN1 EPN2 0.183 22558309

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 NEURL1B EPN2 MI:0362 inference MI:0461 interaction database HIP1 EPN2 MI:0362 inference MI:1106 pathways database WASL EPN2 MI:0362 inference MI:1106 pathways database PIK3C2A EPN2 MI:0362 inference MI:1106 pathways database BIN1 EPN2 MI:0362 inference MI:1106 pathways database FCHO1 EPN2 MI:0362 inference MI:1106 pathways database DVL2 EPN2 MI:0362 inference MI:1106 pathways database GAK EPN2 MI:0362 inference MI:1106 pathways database SYNJ2 EPN2 MI:0362 inference MI:1106 pathways database ARPC2 EPN2 MI:0362 inference MI:1106 pathways database ARPC3 EPN2 MI:0362 inference MI:1106 pathways database ARPC5 EPN2 MI:0362 inference MI:1106 pathways database SYNJ1 EPN2 MI:0362 inference MI:1106 pathways database TGOLN2 EPN2 MI:0362 inference MI:1106 pathways database DNAJC6 EPN2 MI:0362 inference MI:1106 pathways database HIP1R EPN2 MI:0362 inference MI:1106 pathways database VAMP4 EPN2 MI:0362 inference MI:1106 pathways database EED EPN2 MI:0362 inference MI:0461 interaction database NEURL1 EPN2 MI:0362 inference MI:0461 interaction database AP2A2 EPN2 MI:0362 inference MI:0461,MI:1106 interaction database,pathways database EPN2 AP2A1 MI:0362 inference MI:0461,MI:1106 interaction database,pathways database EPN2 EGFR MI:0362 inference MI:1106 pathways database EPN2 LDLR MI:0362 inference MI:1106 pathways database EPN2 EGF MI:0362 inference MI:1106 pathways database EPN2 AVP MI:0362 inference MI:1106 pathways database EPN2 CD4 MI:0362 inference MI:1106 pathways database EPN2 APOE MI:0045 experimental interaction detection MI:0461 interaction database EPN2 TFRC MI:0362 inference MI:1106 pathways database EPN2 TF MI:0362 inference MI:1106 pathways database EPN2 APOB MI:0362 inference MI:1106 pathways database EPN2 CD3D MI:0362 inference MI:1106 pathways database EPN2 ADRB2 MI:0362 inference MI:1106 pathways database EPN2 CHRM2 MI:0362 inference MI:1106 pathways database EPN2 HSP90AB1 MI:0362 inference MI:0461 interaction database EPN2 CLTA MI:0362 inference MI:0461,MI:1106 interaction database,pathways database EPN2 CLTB MI:0362 inference MI:1106 pathways database EPN2 CD3G MI:0362 inference MI:1106 pathways database EPN2 UBB MI:0362 inference MI:0461,MI:1106 interaction database,pathways database EPN2 UBC MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database EPN2 HSPA8 MI:0362 inference MI:1106 pathways database EPN2 IGF2R MI:0362 inference MI:1106 pathways database EPN2 CFTR MI:0362 inference MI:1106 pathways database EPN2 PPP3CB MI:0362 inference MI:0461 interaction database EPN2 HK1 MI:0362 inference MI:0461 interaction database EPN2 RAB5A MI:0362 inference MI:1106 pathways database EPN2 M6PR MI:0362 inference MI:1106 pathways database EPN2 SYT1 MI:0362 inference MI:1106 pathways database EPN2 CBL MI:0362 inference MI:1106 pathways database EPN2 AVPR2 MI:0362 inference MI:1106 pathways database EPN2 UQCRC1 MI:0362 inference MI:0461 interaction database EPN2 ARRB2 MI:0362 inference MI:1106 pathways database EPN2 FLT4 MI:0362 inference MI:0461 interaction database EPN2 KDR MI:0362 inference MI:0461 interaction database EPN2 WNT5A MI:0362 inference MI:1106 pathways database EPN2 EPS15 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database EPN2 ARRB1 MI:0362 inference MI:1106 pathways database EPN2 AMPH MI:0362 inference MI:0461,MI:1106 interaction database,pathways database EPN2 DNM2 MI:0362 inference MI:1106 pathways database EPN2 VAMP7 MI:0362 inference MI:1106 pathways database EPN2 AGFG1 MI:0362 inference MI:1106 pathways database EPN2 CLTCL1 MI:0362 inference MI:1106 pathways database EPN2 AP2S1 MI:0362 inference MI:1106 pathways database EPN2 ARPC4 MI:0362 inference MI:1106 pathways database EPN2 ACTR3 MI:0362 inference MI:1106 pathways database EPN2 ACTR2 MI:0362 inference MI:1106 pathways database EPN2 RPS27A MI:0362 inference MI:0461,MI:1106 interaction database,pathways database EPN2 UBA52 MI:0362 inference MI:0461,MI:1106 interaction database,pathways database EPN2 GRB2 MI:0362 inference MI:1106 pathways database EPN2 AP2B1 MI:0362 inference MI:0461,MI:1106 interaction database,pathways database EPN2 VAMP2 MI:0362 inference MI:1106 pathways database EPN2 TUBA1B MI:0362 inference MI:0461 interaction database EPN2 TUBA4A MI:0362 inference MI:0461 interaction database EPN2 DAB2 MI:0362 inference MI:1106 pathways database EPN2 LRP2 MI:0362 inference MI:1106 pathways database EPN2 CLTC MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database EPN2 SLC6A3 MI:0362 inference MI:0461 interaction database EPN2 OCRL MI:0362 inference MI:1106 pathways database EPN2 ZBTB16 MI:0362 inference MI:0461 interaction database EPN2 PPP3CA MI:0362 inference MI:0461 interaction database EPN2 FCHO2 MI:0362 inference MI:1106 pathways database EPN2 MAP3K1 MI:0362 inference MI:0461 interaction database EPN2 PICALM MI:0362 inference MI:1106 pathways database EPN2 CAMK2B MI:0362 inference MI:0461 interaction database EPN2 LAPTM5 MI:0045 experimental interaction detection MI:0461 interaction database EPN2 TUBA3C MI:0362 inference MI:0461 interaction database EPN2 SCARB2 MI:0362 inference MI:1106 pathways database EPN2 CTTN MI:0362 inference MI:1106 pathways database EPN2 GAPVD1 MI:0362 inference MI:1106 pathways database EPN2 RALBP1 MI:0045 experimental interaction detection MI:0461 interaction database EPN2 TRIP10 MI:0362 inference MI:1106 pathways database EPN2 ITSN1 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database EPN2 VAMP3 MI:0362 inference MI:1106 pathways database EPN2 SLC18A3 MI:0362 inference MI:1106 pathways database EPN2 AAK1 MI:0362 inference MI:1106 pathways database EPN2 LDLRAP1 MI:0362 inference MI:1106 pathways database EPN2 FNBP1L MI:0362 inference MI:1106 pathways database EPN2 KIAA0319 MI:0362 inference MI:1106 pathways database EPN2 TUBA3E MI:0362 inference MI:0461 interaction database EPN2 TUBA1A MI:0362 inference MI:0461 interaction database EPN2 SYT9 MI:0362 inference MI:1106 pathways database EPN2 TMEM17 MI:0045 experimental interaction detection MI:0461 interaction database EPN2 SYT2 MI:0362 inference MI:1106 pathways database EPN2 NECAP1 MI:0362 inference MI:1106 pathways database EPN2 CPEB3 MI:0362 inference MI:0461 interaction database EPN2 REPS2 MI:0362 inference MI:1106 pathways database EPN2 STON2 MI:0362 inference MI:1106 pathways database EPN2 ARPC1A MI:0362 inference MI:1106 pathways database EPN2 USP9X MI:0362 inference MI:0461 interaction database EPN2 AP2M1 MI:0362 inference MI:0461,MI:1106 interaction database,pathways database EPN2 REPS1 MI:0362 inference MI:1106 pathways database EPN2 FNBP1 MI:0362 inference MI:1106 pathways database EPN2 SH3GL2 MI:0362 inference MI:1106 pathways database EPN2 SGIP1 MI:0362 inference MI:1106 pathways database EPN2 VAMP8 MI:0362 inference MI:1106 pathways database EPN2 EPN3 MI:0045 experimental interaction detection MI:0461 interaction database EPN2 EHD1 MI:0362 inference MI:0461 interaction database EPN2 NECAP2 MI:0362 inference MI:0461 interaction database EPN2 SLC2A8 MI:0362 inference MI:1106 pathways database EPN2 GTSE1 MI:0045 experimental interaction detection MI:0461 interaction database EPN2 EHD2 MI:0362 inference MI:0461 interaction database EPN2 EPS15L1 MI:0362 inference MI:0461 interaction database EPN2 UBQLN2 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database EPN2 FZD4 MI:0362 inference MI:1106 pathways database EPN2 PACSIN2 MI:0362 inference MI:1106 pathways database EPN2 RNF11 MI:0045 experimental interaction detection MI:0461 interaction database EPN2 SNX9 MI:0362 inference MI:1106 pathways database EPN2 EPN1 MI:0362 inference MI:0461,MI:1106 interaction database,pathways database