PTM - CPLM Gene Name UniProt ID Type Position Code EPN2; KIAA1065 O95208 Ubiquitination 11 K EPN2; KIAA1065 O95208 Ubiquitination 107 K EPN2; KIAA1065 O95208 Ubiquitination 117 K EPN2; KIAA1065 O95208 Ubiquitination 135 K EPN2; KIAA1065 O95208 Ubiquitination 188 K EPN2; KIAA1065 O95208 Ubiquitination 423 K EPN2; KIAA1065 O95208 Ubiquitination 149 K

PTM - dbPAF Gene Name UniProt ID Position Type Species EPN2; KIAA1065 O95208 111 Y Homo sapiens(Human) EPN2; KIAA1065 O95208 150 T Homo sapiens(Human) EPN2; KIAA1065 O95208 17 Y Homo sapiens(Human) EPN2; KIAA1065 O95208 172 S Homo sapiens(Human) EPN2; KIAA1065 O95208 173 S Homo sapiens(Human) EPN2; KIAA1065 O95208 178 S Homo sapiens(Human) EPN2; KIAA1065 O95208 179 T Homo sapiens(Human) EPN2; KIAA1065 O95208 180 S Homo sapiens(Human) EPN2; KIAA1065 O95208 182 S Homo sapiens(Human) EPN2; KIAA1065 O95208 186 Y Homo sapiens(Human) EPN2; KIAA1065 O95208 192 S Homo sapiens(Human) EPN2; KIAA1065 O95208 195 S Homo sapiens(Human) EPN2; KIAA1065 O95208 196 Y Homo sapiens(Human) EPN2; KIAA1065 O95208 199 S Homo sapiens(Human) EPN2; KIAA1065 O95208 2 T Homo sapiens(Human) EPN2; KIAA1065 O95208 272 T Homo sapiens(Human) EPN2; KIAA1065 O95208 273 S Homo sapiens(Human) EPN2; KIAA1065 O95208 287 S Homo sapiens(Human) EPN2; KIAA1065 O95208 316 T Homo sapiens(Human) EPN2; KIAA1065 O95208 327 S Homo sapiens(Human) EPN2; KIAA1065 O95208 4 S Homo sapiens(Human) EPN2; KIAA1065 O95208 419 S Homo sapiens(Human) EPN2; KIAA1065 O95208 420 S Homo sapiens(Human) EPN2; KIAA1065 O95208 426 S Homo sapiens(Human) EPN2; KIAA1065 O95208 475 T Homo sapiens(Human) EPN2; KIAA1065 O95208 479 S Homo sapiens(Human) EPN2; KIAA1065 O95208 484 T Homo sapiens(Human) EPN2; KIAA1065 O95208 485 T Homo sapiens(Human) EPN2; KIAA1065 O95208 486 S Homo sapiens(Human) EPN2; KIAA1065 O95208 492 S Homo sapiens(Human) EPN2; KIAA1065 O95208 5 S Homo sapiens(Human) EPN2; KIAA1065 O95208 504 S Homo sapiens(Human) EPN2; KIAA1065 O95208 508 T Homo sapiens(Human) EPN2; KIAA1065 O95208 511 S Homo sapiens(Human) EPN2; KIAA1065 O95208 570 S Homo sapiens(Human) EPN2; KIAA1065 O95208 622 S Homo sapiens(Human) EPN2; KIAA1065 O95208 628 S Homo sapiens(Human) EPN2; KIAA1065 O95208 75 Y Homo sapiens(Human) EPN2; KIAA1065 O95208 83 Y Homo sapiens(Human)

PTM - PhosphositePlus UniProt ID MOD_RSD Type SITE_+/-7_AA O95208 K423-ac Acetylation QPASsAGkRAsDAWG O95208 R170-m1 Methylation sNQITFGrGssQPNL O95208 K423-m1 Methylation QPASsAGkRAsDAWG O95208 T2-p Phosphorylation ______MtTssIRRQ O95208 S4-p Phosphorylation ____MtTssIRRQMk O95208 S5-p Phosphorylation ___MtTssIRRQMkN O95208 Y83-p Phosphorylation KALTLLDyLIKTGSE O95208 T150-p Phosphorylation ERAQALKtKERMAQV O95208 S163-p Phosphorylation QVATGMGsNQITFGr O95208 S172-p Phosphorylation QITFGrGssQPNLsT O95208 S173-p Phosphorylation ITFGrGssQPNLsTS O95208 S178-p Phosphorylation GssQPNLsTSHsEQE O95208 S182-p Phosphorylation PNLsTSHsEQEyGKA O95208 Y186-p Phosphorylation TSHsEQEyGKAGGsP O95208 S192-p Phosphorylation EyGKAGGsPAsYHGs O95208 S195-p Phosphorylation KAGGsPAsYHGsPEA O95208 S199-p Phosphorylation sPAsYHGsPEASLCP O95208 S237-p Phosphorylation LPHLGLAsRPNGDWS O95208 T249-p Phosphorylation DWSQPCLtCDRAARA O95208 T272-p Phosphorylation LEQARPQtsGEEELQ O95208 S273-p Phosphorylation EQARPQtsGEEELQL O95208 S287-p Phosphorylation LQLALAMsREVAEQE O95208 T316-p Phosphorylation LEESRRDtVKIPKKK O95208 S327-p Phosphorylation PKKKEHGsLPQQTTL O95208 S408-p Phosphorylation VQSVPKNsDPWAASQ O95208 S420-p Phosphorylation ASQQPASsAGkRAsD O95208 S426-p Phosphorylation SsAGkRAsDAWGAVS O95208 S486-p Phosphorylation SQNNGTTsPDPFEsQ O95208 S492-p Phosphorylation TsPDPFEsQPLTVAS O95208 S504-p Phosphorylation VASSKPSsARKtPES O95208 T508-p Phosphorylation KPSsARKtPESFLGP O95208 S570-p Phosphorylation TLNQLRGsPVLGTST O95208 S622-p Phosphorylation AMMNMVGsVGIPPsA O95208 S628-p Phosphorylation GsVGIPPsAAQATGT O95208 K11-ub Ubiquitination ssIRRQMkNIVNNYS O95208 K107-ub Ubiquitination IFAIQTLkDFQYIDR O95208 K117-ub Ubiquitination QYIDRDGkDQGINVR O95208 K135-ub Ubiquitination KQLVALLkDEERLKA O95208 K423-ub Ubiquitination QPASsAGkRAsDAWG

PTM - dbPTM UniProt ID Position Code Type Resources References O95208 192 S Phosphorylation Swiss-Prot 1010711 17081983 O95208 195 S Phosphorylation Swiss-Prot 1010711 17081983 O95208 492 S Phosphorylation Swiss-Prot 1010711 19413330 O95208 339 D Caspase Phosphositeplus.1010730 18722006 O95208 107 K Ubiquitylation Phosphositeplus.1010730 21890473;21906983 O95208 11 K Ubiquitylation Phosphositeplus.1010730 21890473 O95208 117 K Ubiquitylation Phosphositeplus.1010730 21906983 O95208 135 K Ubiquitylation Phosphositeplus.1010730 21906983 O95208 423 K Ubiquitylation Phosphositeplus.1010730 21906983 O95208 186 Y Phosphorylation Phosphositeplus.1010730 17870612;18083107;18180459;20736484 O95208 83 Y Phosphorylation Phosphositeplus.1010730 20068231 O95208 172 S Phosphorylation HPRD 9.0 18452278 O95208 173 S Phosphorylation HPRD 9.0 15345747 O95208 182 S Phosphorylation HPRD 9.0 15345747 O95208 192 S Phosphorylation HPRD 9.0 17081983,19664995,19651622,20068231 O95208 195 S Phosphorylation HPRD 9.0 17081983,19651622,20068231 O95208 492 S Phosphorylation HPRD 9.0 19413330 O95208 83 Y Phosphorylation HPRD 9.0 20068231

PTM - HPRD Symbol Position Code Type References EPN2 172 S Phosphorylation 18452278 EPN2 173 S Phosphorylation 15345747 EPN2 182 S Phosphorylation 15345747 EPN2 192 S Phosphorylation 17081983,19664995,19651622,20068231 EPN2 195 S Phosphorylation 17081983,19651622,20068231 EPN2 435 S Phosphorylation 19413330 EPN2 492 S Phosphorylation 19413330 EPN2 83 Y Phosphorylation 20068231

PTM - UniProt UniProt ID Position Type PMIDs O95208 173 Phosphoserine 23186163 O95208 570 Phosphoserine 24275569

PTM - PHOSIDA Symbol Accession Code Position Surrounding Sequence Type EPN2 IPI00397380 S 192 YGKAGGpSPASYHG phosphorylation EPN2 IPI00397380 S 195 AGGSPApSYHGSTS phosphorylation

PTM - BioGRID Entrez Gene BioGRID ID Position Code Type PMIDs 22905 116569 - K Ubiquitination 21139048 22905 116569 - K Ubiquitination 21906983 22905 116569 - K Ubiquitination 21890473 22905 116569 - K Ubiquitination 21963094 22905 116569 - K Ubiquitination 23000965

PTM - mUbiSiDa Gene Name Species Ubiquitination Site Ubiquitination Sequence Evidence PMID EPN2 Homo sapiens (Human) 117; 359; 11; 107; 135 "117,YIDRDGKDQGINV; 359,PASSAGKRASDAW; 11,SIRRQMKNIVNNY; 107,FAIQTLKDFQYID; 135,QLVALLKDEERLK" "117:21906983; 359:21906983; 11:21890473; 107:21906983,21890473; 135:21906983" EPN2 Homo sapiens (Human) 117; 188; 366; 107; 135 "117,YIDRDGKDQGINV; 188,SEQEYGKAGGSPA; 366,PASSAGKRASDAW; 107,FAIQTLKDFQYID; 135,QLVALLKDEERLK" 117:21906983; 188:21906983; 366:21906983; 107:21906983; 135:21906983 EPN2 Homo sapiens (Human) 131 "131,PASSAGKRASDAW" 131:21906983 EPN2 Homo sapiens (Human) 117; 107; 135; 423 "117,YIDRDGKDQGINV; 107,FAIQTLKDFQYID; 135,QLVALLKDEERLK; 423,PASSAGKRASDAW" 117:21906983; 107:21906983; 135:21906983; 423:21906983 EPN2 Homo sapiens (Human) 68; 326; 96; 78 "68,FAIQTLKDFQYID; 326,PASSAGKRASDAW; 96,QLVALLKDEERLK; 78,YIDRDGKDQGINV" "68:21890473,21906983; 326:21906983; 96:21906983; 78:21906983" EPN2 Homo sapiens (Human) 117; 188; 366; 107; 135 "117,YIDRDGKDQGINV; 188,SEQEYGKAGGSPA; 366,PASSAGKRASDAW; 107,FAIQTLKDFQYID; 135,QLVALLKDEERLK" "117:21906983; 188:21906983; 366:21906983; 107:21890473,21906983; 135:21906983" EPN2 Homo sapiens (Human) 117; 107; 135; 423 "117,YIDRDGKDQGINV; 107,FAIQTLKDFQYID; 135,QLVALLKDEERLK; 423,PASSAGKRASDAW" "117:21906983; 107:21890473,21906983; 135:21906983; 423:21906983" EPN2 Homo sapiens (Human) 117; 11; 107; 135; 423 "117,YIDRDGKDQGINV; 11,SIRRQMKNIVNNY; 107,FAIQTLKDFQYID; 135,QLVALLKDEERLK; 423,PASSAGKRASDAW" "117:21906983; 11:21890473; 107:21906983,21890473; 135:21906983; 423:21906983" EPN2 Homo sapiens (Human) 11; 107 "11,SIRRQMKNIVNNY; 107,FAIQTLKDFQYID" 11:21890473; 107:21890473 EPN2 Homo sapiens (Human) 11; 107 "11,SIRRQMKNIVNNY; 107,FAIQTLKDFQYID" 11:21890473; 107:21890473