PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus NIFK NLE1 26186194 biogrid exp GP G P GP P GP G GP P GP GP P G P GP P G SPAG7 NLE1 26344197 biogrid exp GP P G P GP P P GP G GP P GP GP P GP P GP P G SIRT7 NLE1 22586326 biogrid exp GP P G P P GP P GP G GP P G GP P GP P GP P G MTHFD1 NLE1 26344197 biogrid exp GP P G P P GP P P GP G GP P GP GP P GP P GP P G CUL3 NLE1 21145461 biogrid exp GP P G P P GP P P GP G GP P GP GP P GP P GP P G HNRNPH3 NLE1 26344197 biogrid exp G G G G G G G G G G G IFI16 NLE1 25693804 biogrid exp G G P GP P GP G G P GP G G G G GBE1 NLE1 26344197 biogrid exp GP P G P P GP P P GP G GP P GP GP P GP P GP P G NOP9 NLE1 26496610 biogrid,intact exp G G P P G P G G G P G G P G G P G CYCS NLE1 26344197 biogrid exp GP P G P P GP P P GP G GP P GP GP P GP P GP P G THAP7 NLE1 26186194 biogrid exp GP G P GP P P GP G GP P GP GP P G P GP P G JUN NLE1 25609649 intact exp GP P G P GP P P G G GP P G G P GP P GP G MDN1 NLE1 26601951 biogrid exp GP G P GP P P G G GP P GP GP P GP P GP P G WDR5 NLE1 17041588 biogrid exp G G G G G G G G G G G OBSL1 NLE1 24711643 biogrid exp GP P G P P GP P P GP G GP P GP GP P GP P GP P G CHMP4B NLE1 26496610 biogrid,intact exp GP P G P P GP P P GP G GP P G GP P G P GP P G EWSR1 NLE1 16189514 hprd,biogrid,mint,intact exp GP P G P P GP P P GP G GP P GP GP P GP P GP P G SKIV2L2 NLE1 26344197 biogrid exp GP P G P P GP P P GP G GP P GP GP P GP P GP P G NLE1 NOL12 26186194 biogrid exp G G G G G G G NSA2 NLE1 26186194 biogrid exp, ortho GP P G P P GP P P G G GP P G GP P GP P GP P G HSPA9 NLE1 ortho GP P G P P GP P P GP G GP P GP GP P GP P GP P G CIRH1A NLE1 ortho GP P G P P GP P P G G GP P G GP P GP P GP P G PRKAA2 NLE1 ortho G P G P P GP P P G G GP P GP GP GP P GP P G NLE1 MRTO4 ortho GP P G P P GP P P G G G P GP GP P G GP P G CDK5 NLE1 ortho P P G P P P P P GP GP P P P P P P P P DDX18 NLE1 ortho GP P G P P GP P P GP G GP P G GP P GP P GP P G RPF2 NLE1 ortho GP P G P P GP P GP G GP P G GP P G P GP P G DDX55 NLE1 ortho GP P G P P GP P P GP G GP P GP GP P GP P GP P G BOP1 NLE1 ortho G G G G G G G G RPS27A NLE1 ortho GP P G P P GP P P GP G GP P GP GP P GP P GP P G YWHAE NLE1 ortho GP P G P P GP P P GP G GP P GP GP P GP P GP P G NLE1 NLE1 ortho GP P G P P GP P P GP G GP P GP GP P GP P GP P G AKT2 NLE1 ortho GP P G P GP P P GP G GP P GP GP P GP P GP P G NLE1 FAM96B ortho GP P G P P GP P P GP G GP P GP GP P GP P GP P G CAD NLE1 ortho GP P G P P GP P P GP G GP P GP GP P G P GP P G NLE1 GLTSCR2 ortho P P P P P P P GP P P P P P GP P P P DHX15 NLE1 ortho G P G P GP P G G G P GP GP P G GP P G RRS1 NLE1 ortho GP P G P P GP P G G GP P GP GP G P GP P G EIF6 NLE1 ortho GP P G P P GP P P GP G GP P GP GP P GP P GP P G AURKB NLE1 ortho P P GP P P P GP P G P P GP P RPL5 NLE1 ortho P P P P P P P P P P P P P P P P P LSG1 NLE1 ortho GP P G P P GP P P GP G GP P GP GP P GP P GP P G GNL2 NLE1 21836163 ortho, pred GP P G P GP P GP G G P G GP P G GP P G GTPBP4 NLE1 21836163 ortho, pred GP P G P P GP P P GP G GP P G GP P GP P GP P G PES1 NLE1 21836163 ortho, pred GP G P P GP P P G G GP P G GP P G P GP P G NLE1 RSL24D1 21836163 ortho, pred GP P G P P GP P P GP G GP P G GP P GP P GP P G DCAF13 NLE1 21836163 pred GP P G P P GP P P GP G GP P G GP P GP P GP P G SP1 NLE1 23023127 pred GP P G P P GP P P GP G GP P GP GP P GP P GP P G NLE1 PRPF19 23023127 pred GP P G P P GP P P GP G GP P GP GP P GP P GP P G ZNF593 NLE1 21836163 pred GP P G P P GP P P GP G GP P GP GP P GP P GP P G SETDB1 NLE1 23023127 pred GP P G P P GP P P GP G GP P GP GP P G P GP P G MIB2 NLE1 23023127 pred P P G P P P P P P P P GP GP P GP P P P G NBN NLE1 23023127 pred GP P G P P GP P P GP G GP P GP GP P GP P GP P G PAFAH1B1 NLE1 23023127 pred GP P G P P GP P P GP G GP P GP GP P GP P GP P G NLE1 PAK1IP1 21836163 pred GP P G P P GP P P GP G GP P GP P P P P GP P WDR12 NLE1 21836163 pred GP P G P P GP P P GP G GP P G GP P GP P GP P G SDAD1 NLE1 21836163 pred G G P GP P G G G P GP GP G G P G CDC20 NLE1 23023127 pred P GP P P GP G P P GP P BYSL NLE1 21836163 pred GP P G P P GP P P P G GP P GP P P GP P P P G GNA12 NLE1 23023127 pred GP P G P GP P P GP G GP P G GP P GP P GP P G SKIL NLE1 23023127 pred GP P G P GP P P G G GP P G G P GP P GP P G GNB2L1 NLE1 23023127 pred P P P P P P P P P P P P P P P MAPK7 NLE1 23023127 pred GP P G P P GP P P GP G GP P GP GP P GP P GP P G GNA13 NLE1 23023127 pred GP P G P P GP P P GP G GP P GP GP P GP P GP P G MBD3 NLE1 23023127 pred GP P G P P GP P P GP G GP P GP G P G P GP P G PTH NLE1 21836163 pred DTX2 NLE1 23023127 pred GP P P P GP P GP GP P G GP GP P GP P G TGFBR1 NLE1 23023127 pred GP G P P GP P P G G GP P G G G P GP G UTP15 NLE1 21836163 pred G G KEAP1 NLE1 23023127 pred GP P G P P GP P P GP G GP P GP GP P GP P GP P G

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B WDR5 NLE1 MI:0004(affinity chromatography technology) 17041588 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_129037 prey bait EWSR1 NLE1 MI:0096(pull down)|MI:0018(two hybrid) 16189514 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_151834|BIOGRID_78980 unspecified role|bait unspecified role|prey SIRT7 NLE1 MI:0004(affinity chromatography technology) 22586326 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_189729 bait prey CUL3 NLE1 MI:0004(affinity chromatography technology) 21145461 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_202195 bait prey NLE1 EWSR1 MI:0018(two hybrid) 16189514 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) - MI:0468(hprd) HPRD_20577 - - UBC NLE1 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 21906983,21963094,22505724 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid) BIOGRID_264607|BIOGRID_224443|BIOGRID_177275 bait|bait|bait prey|prey|prey

PPI - HINT Gene A Gene B PMID Method Quality SPAG7 NLE1 26344197 0401 HT JUN NLE1 25609649 0006 HT MTHFD1 NLE1 26344197 0401 HT SKIV2L2 NLE1 26344197 0401 HT CYCS NLE1 26344197 0401 HT CUL3 NLE1 21145461 0004 HT Q53F48 NLE1 26344197 0401 HT Q59ET0 NLE1 26344197 0401 HT CDK105 NLE1 26186194 0004 HT NOP9 NLE1 26496610,26496610 0007,0004 HT THAP7 NLE1 26186194 0004 HT NIFK NLE1 26186194 0004 HT CHMP4B NLE1 26496610,26496610 0007,0004 HT NLE1 NOL12 26186194 0004 HT SPAG7 NLE1 26344197 0401 HT JUN NLE1 25609649 0006 HT MTHFD1 NLE1 26344197 0401 HT SKIV2L2 NLE1 26344197 0401 HT CYCS NLE1 26344197 0401 HT CUL3 NLE1 21145461 0004 HT Q53F48 NLE1 26344197 0401 HT Q59ET0 NLE1 26344197 0401 HT CDK105 NLE1 26186194 0004 HT NOP9 NLE1 26496610,26496610 0007,0004 HT THAP7 NLE1 26186194 0004 HT NIFK NLE1 26186194 0004 HT CHMP4B NLE1 26496610,26496610 0007,0004 HT NLE1 NOL12 26186194 0004 HT SPAG7 NLE1 26344197 0401 LC MTHFD1 NLE1 26344197 0401 LC SKIV2L2 NLE1 26344197 0401 LC CYCS NLE1 26344197 0401 LC EWSR1 NLE1 16189514,16189514 0398,0018 HT Q53F48 NLE1 26344197 0401 LC Q59ET0 NLE1 26344197 0401 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q9NVX2 Q9NRC8 NLE1 SIRT7 0.126 22586326 Q9NVX2 P11586 NLE1 MTHFD1 0.081 26344197 Q9NVX2 P31942 NLE1 HNRNPH3 0.081 26344197 Q9NVX2 P61964 NLE1 WDR5 0.126 17041588 Q9NVX2 Q04446 NLE1 GBE1 0.081 26344197 Q9NVX2 O75147 NLE1 OBSL1 0.126 24711643 Q9NVX2 O95478 NLE1 NSA2 0.126 26186194 Q9NVX2 P05412 NLE1 JUN 0.126 25609649 Q9NVX2 Q8K1S6 NLE1 SPIRE2 0.236 26496610 Q9NVX2 Q9H444 NLE1 CHMP4B 0.236 26496610 Q9NVX2 Q86U38 NLE1 NOP9 0.236 26496610 Q9NVX2 Q9BT49 NLE1 THAP7 0.126 26186194 Q9NVX2 Q9BYG3 NLE1 NIFK 0.126 26186194 Q9UGY1 Q9NVX2 NOL12 NLE1 0.126 26186194 Q9NVX2 Q13618 NLE1 CUL3 0.126 21145461 Q9NVX2 P99999 NLE1 CYCS 0.081 26344197 Q9NVX2 P42285 NLE1 SKIV2L2 0.081 26344197 Q9NVX2 Q01844 NLE1 EWSR1 0.286 16189514 Q9NVX2 Q16666 NLE1 IFI16 0.126 25693804

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 EIF3CL NLE1 MI:0362 inference MI:0461 interaction database ZNF593 NLE1 MI:0362 inference MI:0461 interaction database PES1 NLE1 MI:0362 inference MI:0461 interaction database NOP56 NLE1 MI:0362 inference MI:0461 interaction database NVL NLE1 MI:0362 inference MI:0461 interaction database DHX15 NLE1 MI:0362 inference MI:0461 interaction database OBSL1 NLE1 MI:0045 experimental interaction detection MI:0461 interaction database CLUH NLE1 MI:0362 inference MI:0461 interaction database UTP20 NLE1 MI:0362 inference MI:0461 interaction database NSA2 NLE1 MI:0045 experimental interaction detection MI:0461 interaction database POLR1A NLE1 MI:0362 inference MI:0461 interaction database RPLP2 NLE1 MI:0362 inference MI:0461 interaction database JUN NLE1 MI:0045 experimental interaction detection MI:0461 interaction database UBC NLE1 MI:0045 experimental interaction detection MI:0461 interaction database MTHFD1 NLE1 MI:0362 inference MI:0461 interaction database FBL NLE1 MI:0362 inference MI:0461 interaction database CAD NLE1 MI:0362 inference MI:0461 interaction database AKT2 NLE1 MI:0362 inference MI:0461 interaction database CBS NLE1 MI:0362 inference MI:0461 interaction database RPL4 NLE1 MI:0362 inference MI:0461 interaction database HSPA9 NLE1 MI:0362 inference MI:0461 interaction database RBM34 NLE1 MI:0362 inference MI:0461 interaction database RPL35 NLE1 MI:0362 inference MI:0461 interaction database NOP2 NLE1 MI:0362 inference MI:0461 interaction database RPL5 NLE1 MI:0362 inference MI:0461 interaction database PRKAA2 NLE1 MI:0362 inference MI:0461 interaction database NAP1L1 NLE1 MI:0362 inference MI:0461 interaction database SNU13 NLE1 MI:0362 inference MI:0461 interaction database EIF3B NLE1 MI:0362 inference MI:0461 interaction database RRP1 NLE1 MI:0362 inference MI:0461 interaction database EIF6 NLE1 MI:0362 inference MI:0461 interaction database WDR5 NLE1 MI:0045 experimental interaction detection MI:0461 interaction database PSMC5 NLE1 MI:0362 inference MI:0461 interaction database SUMO1 NLE1 MI:0045 experimental interaction detection MI:0461 interaction database RPL38 NLE1 MI:0362 inference MI:0461 interaction database EEF1A1 NLE1 MI:0362 inference MI:0461 interaction database TUBA1B NLE1 MI:0362 inference MI:0461 interaction database TUBA4A NLE1 MI:0362 inference MI:0461 interaction database EWSR1 NLE1 MI:0045 experimental interaction detection MI:0461 interaction database CEBPZ NLE1 MI:0362 inference MI:0461 interaction database EEF1A2 NLE1 MI:0362 inference MI:0461 interaction database SPIRE1 NLE1 MI:0362 inference MI:0461 interaction database CUL3 NLE1 MI:0045 experimental interaction detection MI:0461 interaction database TUBA3C NLE1 MI:0362 inference MI:0461 interaction database GNL2 NLE1 MI:0362 inference MI:0461 interaction database BOP1 NLE1 MI:0362 inference MI:0461 interaction database EIF3A NLE1 MI:0362 inference MI:0461 interaction database RRP1B NLE1 MI:0362 inference MI:0461 interaction database BMS1 NLE1 MI:0362 inference MI:0461 interaction database RRS1 NLE1 MI:0362 inference MI:0461 interaction database PUM3 NLE1 MI:0362 inference MI:0461 interaction database SKIV2L NLE1 MI:0362 inference MI:0461 interaction database NEDD8 NLE1 MI:0045 experimental interaction detection MI:0461 interaction database IFI16 NLE1 MI:0045 experimental interaction detection MI:0461 interaction database RRP12 NLE1 MI:0362 inference MI:0461 interaction database UTP14C NLE1 MI:0362 inference MI:0461 interaction database TUBA3E NLE1 MI:0362 inference MI:0461 interaction database TUBA1A NLE1 MI:0362 inference MI:0461 interaction database NOP9 NLE1 MI:0045 experimental interaction detection MI:0461 interaction database SPATA5 NLE1 MI:0362 inference MI:0461 interaction database DDX55 NLE1 MI:0362 inference MI:0461 interaction database DDX54 NLE1 MI:0362 inference MI:0461 interaction database BRIX1 NLE1 MI:0362 inference MI:0461 interaction database NOC3L NLE1 MI:0362 inference MI:0461 interaction database SPIRE2 NLE1 MI:0362 inference MI:0461 interaction database GCN1 NLE1 MI:0362 inference MI:0461 interaction database ZNF622 NLE1 MI:0362 inference MI:0461 interaction database NMD3 NLE1 MI:0362 inference MI:0461 interaction database AURKB NLE1 MI:0362 inference MI:0461 interaction database DDX27 NLE1 MI:0362 inference MI:0461 interaction database EIF3C NLE1 MI:0362 inference MI:0461 interaction database NAP1L4 NLE1 MI:0362 inference MI:0461 interaction database THAP7 NLE1 MI:0045 experimental interaction detection MI:0461 interaction database UTP14A NLE1 MI:0362 inference MI:0461 interaction database GNL3 NLE1 MI:0362 inference MI:0461 interaction database NIFK NLE1 MI:0045 experimental interaction detection MI:0461 interaction database GTPBP4 NLE1 MI:0362 inference MI:0461 interaction database WDR12 NLE1 MI:0362 inference MI:0461 interaction database DDX24 NLE1 MI:0362 inference MI:0461 interaction database LSG1 NLE1 MI:0362 inference MI:0461 interaction database NAT10 NLE1 MI:0362 inference MI:0461 interaction database CHMP4B NLE1 MI:0045 experimental interaction detection MI:0461 interaction database HEATR1 NLE1 MI:0362 inference MI:0461 interaction database NOL6 NLE1 MI:0362 inference MI:0461 interaction database RPF2 NLE1 MI:0362 inference MI:0461 interaction database RPF1 NLE1 MI:0362 inference MI:0461 interaction database POLR1B NLE1 MI:0362 inference MI:0461 interaction database PPAN NLE1 MI:0362 inference MI:0461 interaction database SIRT7 NLE1 MI:0045 experimental interaction detection MI:0461 interaction database MDN1 NLE1 MI:0045 experimental interaction detection MI:0461 interaction database ABCF3 NLE1 MI:0362 inference MI:0461 interaction database GNL3L NLE1 MI:0362 inference MI:0461 interaction database DDX18 NLE1 MI:0362 inference MI:0461 interaction database SDAD1 NLE1 MI:0362 inference MI:0461 interaction database NLE1 RBM28 MI:0362 inference MI:0461 interaction database NLE1 TUBA8 MI:0362 inference MI:0461 interaction database NLE1 DDX56 MI:0362 inference MI:0461 interaction database NLE1 GLTSCR2 MI:0362 inference MI:0461 interaction database NLE1 NOL12 MI:0045 experimental interaction detection MI:0461 interaction database NLE1 RSL24D1 MI:0362 inference MI:0461 interaction database NLE1 MRTO4 MI:0362 inference MI:0461 interaction database NLE1 NAP1L2 MI:0362 inference MI:0461 interaction database NLE1 AURKC MI:0362 inference MI:0461 interaction database NLE1 NIP7 MI:0362 inference MI:0461 interaction database NLE1 AKT3 MI:0362 inference MI:0461 interaction database NLE1 FAM96B MI:0362 inference MI:0461 interaction database NLE1 NOC2L MI:0362 inference MI:0461 interaction database NLE1 ARFGEF2 MI:0362 inference MI:0461 interaction database NLE1 ARFGEF1 MI:0362 inference MI:0461 interaction database