PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus CPSF7 ITCH 16055720 biogrid,i2d exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G ITCH HNRNPUL1 16055720 biogrid,i2d exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G PABPC1 ITCH 16055720 biogrid,i2d exp GP GP G G GP GP G G GP G GP GP GP GP G GP GP GP GP G GP GP GP G GP GP GP GP G TRPV1 ITCH 17110928 hprd exp P P P P P P P P P P P P P P P P MAVS ITCH 19881509 innatedb,biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G ITCH SH3GLB1 19341794 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G WDR48 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ITCH 23236378 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G WASL ITCH 23414517 intact exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G ARRDC1 ITCH 21191027,23886940,26186194,23236378 biogrid exp G GP G G G GP G GP GP G GP GP G G G GP GP G GP G GP G G GP GP G GP GP G PTCH1 ITCH 25092867 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G DTX3L ITCH 24790097 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP G G GP G GP GP GP GP GP GP G DVL3 ITCH 22826439 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G AMOT ITCH 23564455,24101513,22385262 biogrid exp G G G G G G G G G G G G G G G G G G G MGRN1 ITCH 23253940 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G CAV1 ITCH 22275353 biogrid exp GP G G G G GP G GP GP G GP GP GP G G G GP GP G G GP GP G G G G G G G LATS1 ITCH 23564455,21212414,24107629,21383157 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP G GP GP G LAPTM5 ITCH 22009753 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G G GP GP G GP GP GP GP G PLEKHB2 ITCH 26186194 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G POU5F1 ITCH 23255053 biogrid exp P P P P P P P P P P P P P P P P P P P P P P DVL1 ITCH 22826439 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G TNFRSF10B ITCH 19808964 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G ITCH GGA3 25195858 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP G GP GP GP GP GP GP G GBA ITCH 23255161 biogrid exp P P P P P P P P P P P P P P P P P P P P P ITCH ITCH 17719543,11526121,18718449,16055720,11724934,17592138,17038327,16446428,17996703,23146885,24790097,22496338 hprd,biogrid,i2d exp, ortho GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G KLF10 ITCH 18278048 biogrid exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G USP13 ITCH 19615732 biogrid,intact exp, ortho GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP G GP GP G GLI1 ITCH 20818436 biogrid,i2d,intact exp, ortho GP G G G P G G GP P P P G GP GP GP P P G P GP GP GP G UBC ITCH 19343052,23644597,23287719,22496338 biogrid,mint,intact exp, ortho GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G ITCH PI4K2A 23146885 intact exp, ortho G GP G G GP GP G G GP G GP GP GP GP G G GP G GP G GP G G G G GP GP GP G POLR2B ITCH 16055720 biogrid,i2d exp, ortho GP GP G G GP GP G G GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G ITCH NDFIP1 25632008, 25402006, 23023127 biogrid exp, ortho, pred GP GP G G GP GP G G GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP G GP GP G TGFBR1 ITCH 15350225, 25402006 biogrid exp, ortho, pred GP G G G GP GP G GP GP G GP GP GP G G GP GP G G G G G G G GP G GP G G ITCH TRAF6 18246070, 25402006, 23023127 biogrid exp, ortho, pred GP GP G G GP G G GP GP G GP GP GP G G GP G GP G G GP GP GP G GP GP GP GP G USP9X ITCH 17038327,19341794, 25402006 innatedb,biogrid exp, ortho, pred GP GP G G GP GP G G GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G CFLAR ITCH 21474069,19090833,19808964,18559494, 25402006 biogrid exp, ortho, pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G NOTCH1 ITCH 23886940,12682059, 25402006 hprd,biogrid exp, ortho, pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G TAX1BP1 ITCH 18246070, 25402006 innatedb,biogrid exp, ortho, pred GP GP G G GP GP G GP GP G GP G G GP G G GP GP G G GP G GP GP G G GP GP G RIPK1 ITCH 19131965,18246070, 25402006 innatedb,hprd,biogrid exp, ortho, pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G ITCH CYLD 22057290, 23023127 biogrid,intact exp, ortho, pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP P G GP GP GP GP GP GP GP GP ITCH RNF11 19131965,14559117,20676133,22507528, 25402006, 23023127 hprd,biogrid,i2d,mint,intact,bci exp, ortho, pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G MAPK8 ITCH 16446428, 25402006 biogrid exp, ortho, pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G SMAD2 ITCH 15350225, 25402006 biogrid exp, ortho, pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G OCLN ITCH 11782481,19478092, 25402006 hprd,biogrid exp, ortho, pred GP G G G G GP G G GP G GP GP GP G G GP GP GP GP G GP GP GP G GP G GP GP G ITCH SNX9 20491914, 25402006 biogrid,mint,intact exp, ortho, pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G JUN ITCH 17110928,19806201,16901904,19818398, 25402006 hprd,biogrid exp, ortho, pred GP GP G G G GP G G GP G GP G GP G G GP GP G G G GP G GP G GP G GP G G MAP2K4 ITCH 19737936, 25402006 biogrid exp, pred GP GP G G GP GP G G GP G GP G GP G G G GP G G G GP G G G G G GP GP G SMAD3 ITCH 15051726, 25402006, 23023127 biogrid exp, pred GP GP G G G GP G G G G G G GP GP G G GP G GP G GP G G G G G G G G FYN ITCH 16387660, 25402006, 23023127 biogrid exp, pred G GP G G GP GP G G GP G GP GP G GP G G GP G G G G G G G G GP G G G ITCH TP63 20855944,23370280,22935697,16908849, 25402006 biogrid exp, pred GP G G G G G G G G G G G G G G G G G G GP GP G G G G G NFE2 ITCH 18718448,11318614, 25402006 innatedb,biogrid exp, pred P P G GP P P P P P P P P P P P P P P P P G P P NUDT21 ITCH 16055720, 25402006 biogrid,i2d exp, pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP GP GP GP G ARRB2 ITCH 18544533,17947233, 25402006 biogrid exp, pred G G G G G G G G G G G G G G G G G G G G G G G G G G ITCH NDFIP2 20522958,15252135, 25402006 hprd,biogrid exp, pred GP G G G GP GP G G GP G GP G GP GP G GP GP G GP G G G GP GP GP GP GP GP G UBE2D3 ITCH 19881509,23644597, 25402006, 23023127 innatedb,biogrid exp, pred GP G G G GP GP G G GP G GP GP GP GP G G GP GP GP G GP GP G GP G GP GP GP G UBE2D2 ITCH 11724934,22496338, 25402006, 23023127 biogrid exp, pred GP G G G GP GP G G GP G GP GP GP GP G G GP GP GP G GP GP G GP G GP GP GP G NEDD4 ITCH 15703212, 25402006, 23023127 innatedb exp, pred GP GP G GP P G GP GP GP G GP GP G GP GP GP GP G GP GP GP GP GP GP GP P G SMAD6 ITCH 15946939,24850914, 25402006 innatedb,biogrid exp, pred G G G G G G G G G G G G G G G G G G G G G G G YAP1 ITCH 17110958, 25402006 biogrid exp, pred GP GP G P GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G UBE2E3 ITCH 22496338, 23023127 biogrid exp, pred GP GP G G G GP G G GP G GP G G GP G GP GP GP G G GP G G GP GP G GP GP G SMAD7 ITCH 15946939,22773947, 25402006, 23023127 innatedb,biogrid exp, pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP P G CSNK2A1 ITCH 17437719, 25402006 biogrid exp, pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G POLR2E ITCH 16055720, 25402006 biogrid,i2d exp, pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G SPG20 ITCH 19580544,19765186,16055720,19307600,20504295, 25402006 biogrid,i2d,intact exp, pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G UBE2E1 ITCH 19737936,15350225, 25402006, 23023127 biogrid exp, pred GP GP G G G GP G G GP G GP G G GP G GP GP GP G G GP G G GP GP G GP GP G DTX1 ITCH 17028573,18628966, 25402006 hprd,biogrid,mint,intact exp, pred GP G G G G GP G G GP G GP GP P G G GP GP GP G P P GP G GP G GP GP G SCNN1A ITCH 11244092, 25402006 biogrid exp, pred GP GP P P P GP GP P GP GP G GP P P GP G P GP GP P GP P GP GP G ITCH CBLC 12226085, 25402006 hprd,biogrid,mint,intact exp, pred P P P P P P GP P P P P P P P P P UBE2L3 ITCH 17719543,18718449,25632008,15678106,20068034,15350225,17592138,17996703,17038327,22009753, 25402006, 23023127 innatedb,biogrid exp, pred GP G G G G GP G GP GP G GP G G G G GP GP G GP G G G GP GP GP G GP GP G POLR2A ITCH 16055720, 25402006 hprd,biogrid,i2d,bci exp, pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G NUMB ITCH 20818436,18628966,12682059, 25402006 hprd,biogrid,bci exp, pred GP GP G G GP GP G GP GP G GP GP GP G G GP GP GP GP G GP GP GP GP GP GP GP GP G MAP3K7 ITCH 25632008, 25402006 biogrid exp, pred GP GP G G G GP G G GP G G GP GP G G G GP G GP G GP GP G G G G GP GP G UBE2G1 ITCH 22826439,16446428, 23023127 biogrid exp, pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G MDM2 ITCH 26025930,21093410, 25402006 biogrid exp, pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G WBP2 ITCH 16055720, 25402006 biogrid,i2d exp, pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G NEDD9 ITCH 15051726, 25402006 hprd,biogrid,mint,intact,bci exp, pred GP GP G G GP GP G GP GP GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G CUL3 ITCH 21145461, 23023127 biogrid exp, pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G ERBB4 ITCH 17463226,18334649, 25402006 innatedb,biogrid,dip exp, pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP P GP GP G CPSF6 ITCH 16055720, 25402006 hprd,biogrid,i2d exp, pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G GRB2 ITCH 26344197, 23023127 biogrid exp, pred GP GP G G GP GP G G GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G EGFR ITCH 24797263, 25402006 biogrid exp, pred GP GP G GP G G GP G GP GP G G G GP GP G G G GP GP G GP GP G GP GP G CBL ITCH 12226085,19341794, 25402006 hprd,biogrid,mint,intact exp, pred G GP G G GP GP G G GP G GP G GP GP G G GP GP G G G G G G G GP G GP G ITCH SH3GL2 14684745,17038327, 25402006 innatedb,hprd,biogrid,i2d,mint,intact exp, pred G GP G G G GP GP G G MLANA ITCH 15703212,20491914, 25402006 innatedb,biogrid,intact exp, pred G G G CDC34 ITCH 22496338, 23023127 biogrid exp, pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G UBE2K ITCH 22496338, 23023127 biogrid exp, pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G SCNN1B ITCH 11244092, 25402006 biogrid exp, pred GP GP G G P G GP G GP GP GP P G P P GP GP GP GP GP GP GP P G SGK3 ITCH 16888620, 25402006, 23023127 hprd,biogrid,mint,intact exp, pred P P P P P P P P P P P P P P P P P P P P P P ATN1 ITCH 9647693, 25402006 hprd,biogrid,i2d,bci exp, pred GP GP G G GP GP G GP GP G GP GP G G G GP GP GP GP G GP GP GP GP GP GP GP GP G ARRB1 ITCH 18544533,17947233, 25402006 innatedb,biogrid exp, pred GP G G G GP GP G G GP G GP G GP G G GP GP G GP G GP GP GP G GP GP GP GP G HGS ITCH 14602072, 25402006 biogrid exp, pred GP GP G G GP GP G GP GP G GP G GP G G GP GP GP GP G GP GP GP GP GP G GP GP G POLR2C ITCH 16055720, 25402006 biogrid,i2d exp, pred GP GP G G GP GP G GP GP G GP G GP GP G GP GP GP GP G GP G GP GP GP G GP GP G TP73 ITCH 17110958,17592138,15678106, 25402006 innatedb,hprd,biogrid,i2d,mint,intact,dip exp, pred G G G G G TP53 ITCH 21474069,18559494, 25402006 biogrid exp, pred G G G G G G G G G G G G G G G GP G G G G GP G G G GP G G GP G ITCH UBE2E2 19549727, 23023127 intact exp, pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G PCBP2 ITCH 19881509, 23023127 innatedb,biogrid exp, pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G PTPN11 ITCH ortho GP GP G G G GP G G GP G GP GP GP GP G GP GP GP GP G GP GP GP G GP GP GP GP G RALBP1 ITCH 25402006 ortho, pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G TRAF2 ITCH 25402006, 23023127 ortho, pred P P P P P P P P P P P P P P P P P P P GP GP P JUNB ITCH 25402006 ortho, pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G ACVR1B ITCH 25402006 pred G G G G G GP G G GP G GP GP GP G G GP GP G GP G GP G G G GP G GP GP G MAPK1 ITCH 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G SOCS7 ITCH 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G GABARAPL2 ITCH 25402006, 23023127 pred G GP G G GP GP G GP GP G GP G G G G GP GP G GP G G GP GP G GP G GP GP G FRK ITCH 23023127 pred P P P P P P P P P P P P P P P P P P P ITCH TRIB1 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G CD86 ITCH 23023127 pred GP G G G GP GP G G P G GP GP GP G GP GP G P G GP P GP G P GP GP P CD276 ITCH 23023127 pred GP GP G G GP GP G G GP G GP GP GP GP G GP GP GP GP G GP GP GP G GP GP GP GP G PLK1 ITCH 23023127 pred P P G G GP P G GP GP P P P GP GP GP GP GP G GP P GP GP GP P P GP PREX1 ITCH 23023127 pred GP GP G G GP GP G GP GP G GP G GP GP G GP GP G GP G GP GP GP GP GP GP GP GP G PDCD6IP ITCH 25402006 pred G GP G G GP GP G GP GP G GP GP GP G G GP GP GP GP G GP GP GP GP GP G GP GP G NCK2 ITCH 23023127 pred G GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP 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GP G PRKCD ITCH 25402006, 23023127 pred GP GP G G GP GP G GP GP GP P GP GP G GP GP GP GP GP GP GP P GP GP GP GP G HSPA8 ITCH 25402006 pred P P P P P P P P P P P P P P P P ITCH TESK2 23023127 pred GP GP G G GP GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP G GP GP GP GP G DNM2 ITCH 25402006 pred GP GP G G G GP G GP GP G GP G GP GP G GP GP G GP G GP GP GP G GP GP GP GP G CREBBP ITCH 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G ITCH ACTR3B 23023127 pred GP GP G P GP G P P G GP GP P P G P GP GP GP G P GP GP GP GP P GP GP ITCH STK31 23023127 pred P P P P P P P P P P P GP PROC ITCH 23023127 pred GP GP P P USP5 ITCH 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP G GP GP GP GP GP G ITCH PLEKHA1 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G ITCH ASAP1 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP G GP GP GP GP G BRCA1 ITCH 25402006 pred P P G GP P P P P P P P GP P P P P P P P P P P GP CLTA ITCH 25402006 pred GP GP G G GP GP G G GP G GP GP GP GP G GP GP G GP G GP GP GP G GP G GP GP G PIAS4 ITCH 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G DPYSL2 ITCH 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G OS9 ITCH 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G EEF1A2 ITCH 25402006 pred G G GP G GP G G P P G G GP GP G P GP G GP G GP G G FGD6 ITCH 23023127 pred P P P P P P P P P P P P P P GP P P P P P P P G GSK3A ITCH 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G PAK1 ITCH 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G PIN1 ITCH 25402006, 23023127 pred G GP G G GP GP G G GP G G G G GP G G GP G P G P GP G G G G GP GP G KLK8 ITCH 23023127 pred GP G G G G G G G G G GP G G G G G G G G G G G G G G G G G UBE2D1 ITCH 25402006, 23023127 pred GP G G G GP GP G G GP G GP GP GP GP G G GP GP GP G GP GP G GP G GP GP GP G UBE2H ITCH 23023127 pred GP GP G G GP GP G GP G G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G PRPF40B ITCH 23023127 pred P P P P P P P P P P P P P P P P P P P P A2M ITCH 23023127 pred G G G G G GP G G GP G G GP G G G G GP G G G GP G G G G G G G G ZEB2 ITCH 23023127 pred G G G G GP GP G GP G G GP GP GP GP G G GP G G G G G G GP G G G CRKL ITCH 25402006 pred GP G G G GP GP G G GP G G G GP GP G GP GP G GP G GP GP G G GP GP GP G G ITCH UBE2T 23023127 pred G G G GP G GP P P P GP GP P GP P G GP P GP G PLD2 ITCH 23023127 pred GP GP G G GP GP G GP GP G GP GP GP G G GP GP GP GP G GP GP GP G GP G GP GP G HSP90AA1 ITCH 25402006 pred GP GP G G G GP G G GP G G G G G G G GP G G G GP G G G G G G GP G ATF2 ITCH 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP G GP GP GP GP G DDX3X ITCH 25402006 pred G GP G G GP GP G G GP G G G GP GP G GP GP G GP G GP GP GP G GP GP GP GP G ITCH WWP1 25402006, 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G CSNK1E ITCH 23023127 pred GP GP G G G GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP GP GP GP G AGAP7P ITCH 23023127 pred POLR2H ITCH 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G VAPB ITCH 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G CALCRL ITCH 23023127 pred GP GP G GP P G G GP GP GP GP GP G GP GP GP P GP GP GP GP GP G GP P G MAP3K11 ITCH 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G NFKBID ITCH 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G P GP GP P GP GP GP GP G GTF2F2 ITCH 25402006 pred GP P G GP P G GP P G P P P P G P GP G P G P GP GP GP GP P GP GP KLKB1 ITCH 23023127 pred GP P GP G GP P G GP GP P GP GP GP GP G P P P G GP P P GP

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q96J02 Q99962 - 14737190 - X 2 Q96J02 pull down 16055720 association C 6 Q96J02 pull down 16055720 association C 4 Q96J02 Q93008 coimmunoprecipitation 17038327 association X 2 Q96J02 Q93008 affinity chromatography technology 17038327 association X 2 Q96J02 Q93008 mass spectrometry studies of complexes 17038327 association X 2 Q96J02 pull down 16055720 association C 5 Q15303 Q96J02 pull down 18334649 physical association X 2 Q15303 Q96J02 anti bait coimmunoprecipitation 18334649 physical association X 2 Q15303 Q96J02 anti bait coimmunoprecipitation 18334649 physical association X 2 Q15303 Q96J02 anti tag coimmunoprecipitation 18334649 physical association X 2 Q96J02 A0A024R4C3 pull down 17592138 direct interaction X 2 Q96J02 A0A024R4C3 pull down 17592138 direct interaction X 2 O75113 Q96J02 pull down 17592138 direct interaction X 2 O75113 Q96J02 pull down 17592138 direct interaction X 2 O75113 Q96J02 anti tag coimmunoprecipitation 17592138 direct interaction X 2 Q96J02 pull down 17592138 - C 3 Q96J02 P62987 anti tag coimmunoprecipitation 17592138 physical association X 2 Q96J02 tandem affinity purification 19765186 association C 20 Q96J02 anti tag coimmunoprecipitation 20491914 association C 3 O15350-8 Q96J02 anti tag coimmunoprecipitation 15678106 physical association X 2 O15350-8 Q96J02 anti tag coimmunoprecipitation 15678106 physical association X 2 Q96J02 pull down 20491914 association C 3 Q96J02 tandem affinity purification 23455153 association C 185 Q96J02 anti tag coimmunoprecipitation 21903422 association C 19 Q96J02 Q9ULV8 two hybrid 12226085 physical association X 2 Q96J02 Q9ULV8 fluorescence microscopy 12226085 colocalization X 2 Q96J02 Q9ULV8 pull down 12226085 physical association X 2 Q96J02 Q9ULV8 pull down 12226085 physical association X 2 Q96J02 Q9ULV8 anti tag coimmunoprecipitation 12226085 physical association X 2 Q96J02 A0A024R4C3 anti tag coimmunoprecipitation 15678106 physical association X 2 Q96J02 A0A024R4C3 pull down 15678106 physical association X 2 Q96J02 A0A024R4C3 pull down 15678106 ubiquitination reaction X 2 Q96J02 A0A024R4C3 anti tag coimmunoprecipitation 15678106 physical association X 2 Q96J02 A0A024R4C3 phage display 15678106 physical association X 2 Q96J02 A0A024R4C3 anti bait coimmunoprecipitation 15678106 physical association X 2 Q96J02 Q86Y01 anti tag coimmunoprecipitation 17028573 physical association X 2 Q96J02 Q86Y01 imaging technique 17028573 colocalization X 2 Q96J02 P0CG47 enzymatic study 17719543 enzymatic reaction X 2 Q96J02 Q9Y5X1 anti tag coimmunoprecipitation 20491914 physical association X 2 Q96J02 Q9Y5X1 anti tag coimmunoprecipitation 20491914 physical association X 2 Q96J02 Q9Y5X1 pull down 20491914 physical association X 2 Q96J02 Q9Y5X1 pull down 20491914 physical association X 2 Q96J02 Q9Y5X1 anti tag coimmunoprecipitation 20491914 physical association X 2 Q96J02 Q9Y5X1 anti bait coimmunoprecipitation 20491914 physical association X 2 Q96J02 Q9Y3C5 pull down 20676133 direct interaction X 2 Q96J02 Q9Y3C5 anti tag coimmunoprecipitation 20676133 physical association X 2 Q96J02 Q5NHP0 two hybrid pooling approach 20711500 physical association X 2 Q96J02 Q38SD2 protein array 24947832 direct interaction X 2 Q96RF0 Q96J02 anti tag coimmunoprecipitation 20491914 physical association X 2 Q9QZS3-2 Q96J02 pull down 20818436 physical association X 2 Q9QZS3-2 Q96J02 anti tag coimmunoprecipitation 20818436 physical association X 2 Q96J02 anti tag coimmunoprecipitation 19615732 physical association C 18 A0A024R807 Q96J02 protein kinase assay 16888620 phosphorylation reaction X 2 A0A024R807 Q96J02 two hybrid 16888620 physical association X 2 A0A024R807 Q96J02 anti tag coimmunoprecipitation 16888620 physical association X 2 A0A024R807 Q96J02 fluorescence microscopy 16888620 colocalization X 2 A0A024R807 Q96J02 pull down 16888620 physical association X 2 Q96J02 P22681 anti tag coimmunoprecipitation 12226085 physical association X 2 Q96J02 Q99962 imaging technique 14684745 colocalization X 2 Q96J02 Q99962 anti tag coimmunoprecipitation 14684745 physical association X 2 Q96J02 Q99962 experimental interaction detection 14684745 ubiquitination reaction X 2 Q96J02 O35179 pull down 14684745 physical association X 2 Q96J02 P13285 nuclear magnetic resonance 17174309 direct interaction X 2 Q96J02 P13285 nuclear magnetic resonance 17174309 direct interaction X 2 Q96J02 A0A024R2Q2 two hybrid 19549727 physical association X 2 Q96J02 P70444 anti tag coimmunoprecipitation 20392206 physical association X 2 Q96J02 P70444 bioluminescence resonance energy transfer 20392206 physical association X 2 Q96J02 P08151 anti tag coimmunoprecipitation 20818436 physical association X 2 Q96J02 P08151 pull down 20818436 physical association X 2 Q96J02 P08151 pull down 20818436 direct interaction X 2 Q96J02 P08151 anti tag coimmunoprecipitation 20818436 physical association X 2 Q96J02 Q9H469 anti tag coimmunoprecipitation 21572392 physical association X 2 Q96J02 Q9NQC7 anti tag coimmunoprecipitation 22057290 physical association X 2 Q96J02 Q9NQC7 anti tag coimmunoprecipitation 22057290 physical association X 2 Q96J02 Q9NQC7 anti tag coimmunoprecipitation 22057290 physical association X 2 Q96J02 Q9BTU6 nuclear magnetic resonance 23146885 direct interaction X 2 Q96J02 Q9BTU6 fluorescence microscopy 23146885 colocalization X 2 Q96J02 Q9BTU6 pull down 23146885 physical association X 2 Q96J02 Q9BTU6 pull down 23146885 physical association X 2 Q96J02 Q9BTU6 pull down 23146885 physical association X 2 Q96J02 O00401 two hybrid fragment pooling approach 23414517 physical association X 2 Q96J02 Q13625 anti bait coimmunoprecipitation 25436413 physical association X 2 Q96J02 Q13625 anti bait coimmunoprecipitation 25436413 physical association X 2 Q2TBE6 Q96J02 anti bait coimmunoprecipitation 23146885 physical association X 2 Q14511 Q96J02 two hybrid 15051726 physical association X 2 Q14511 Q96J02 anti bait coimmunoprecipitation 15051726 physical association X 2 Q14511 Q96J02 pull down 15051726 physical association X 2 Q9EPK8 Q96J02 anti tag coimmunoprecipitation 17110928 physical association X 2 Q9EPK8 Q96J02 imaging technique 17110928 colocalization X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B N4BP1 ITCH MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 17592138 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_118720|BIOGRID_118719 prey|prey bait|bait ARRB1 ITCH MI:0004(affinity chromatography technology) 18544533 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_116481 bait prey PRKACA ITCH MI:0686(unspecified method) 17437719 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_197415 bait prey CDC34 ITCH MI:0415(enzymatic study) 22496338 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_226070 prey bait USP9X ITCH MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 17038327,19341794 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid) BIOGRID_153121|BIOGRID_122321|BIOGRID_122320 prey|prey|prey bait|bait|bait DAZAP1 ITCH MI:0004(affinity chromatography technology)|MI:0493(in vivo) 16055720 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|- (biogrid)|MI:0468(hprd) BIOGRID_297860|HPRD_39749 prey|- bait|- ARR3 ITCH MI:0004(affinity chromatography technology) 17947233 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_117820 prey bait MAVS ITCH MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 19881509 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_195925|BIOGRID_195923 prey|bait bait|prey UBE2J2 ITCH MI:0415(enzymatic study) 22496338 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_226069 prey bait NUDT21 ITCH MI:0493(in vivo)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0493(in vivo)|MI:0493(in vivo) 16055720 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) -|MI:0915(physical association)|MI:0407(direct interaction)|-|- MI:0468(hprd)|(biogrid)|(biogrid)|MI:0468(hprd)|MI:0468(hprd) HPRD_39757|BIOGRID_132710|BIOGRID_132711|HPRD_39753|HPRD_39752 -|prey|prey|-|- -|bait|bait|-|- TP73 ITCH MI:0084(phage display)|MI:0084(phage display)|MI:0004(affinity chromatography technology)|MI:0084(phage display)|MI:0084(phage display)|MI:0084(phage display)|MI:0084(phage display)|MI:0084(phage display)|MI:0084(phage display)|MI:0084(phage display)|MI:0084(phage display)|MI:0084(phage display)|MI:0084(phage display)|MI:0084(phage display)|MI:0084(phage display)|MI:0004(affinity chromatography technology)|MI:0084(phage display)|MI:0084(phage display)|MI:0084(phage display)|MI:0084(phage display)|MI:0084(phage display)|MI:0084(phage display)|MI:0084(phage display)|MI:0084(phage display)|MI:0084(phage display)|MI:0084(phage display)|MI:0096(pull down)|MI:0493(in vivo)|MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down) 15678106,17110958,17592138 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0220(ubiquitination reaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0220(ubiquitination reaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0220(ubiquitination reaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|-|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association) MI:0471(mint)|(intact)|(biogrid)|(intact)|(intact)|MI:0471(mint)|MI:0471(mint)|(intact)|(intact)|MI:0471(mint)|MI:0471(mint)|MI:0471(mint)|MI:0471(mint)|MI:0471(mint)|MI:0471(mint)|(biogrid)|MI:0471(mint)|MI:0471(mint)|MI:0471(mint)|MI:0471(mint)|MI:0471(mint)|MI:0471(mint)|(intact)|MI:0471(mint)|(intact)|(intact)|(biogrid)|MI:0468(hprd)|(biogrid)|(biogrid)|(biogrid) MINT_51862|UniProt_80817|BIOGRID_118738|UniProt_80816|UniProt_80814|MINT_51866|MINT_51865|UniProt_80813|UniProt_80812|MINT_51863|MINT_84308|MINT_84307|MINT_84303|MINT_84297|MINT_84302|BIOGRID_122148|MINT_84301|MINT_84300|MINT_51867|MINT_51868|MINT_84298|MINT_51873|UniProt_80821|MINT_51872|UniProt_80822|UniProt_80823|BIOGRID_129247|HPRD_31203|BIOGRID_129242|BIOGRID_129243|BIOGRID_129244 null|null|prey|null|null|null|null|null|null|null|null|null|null|null|bait|bait|null|null|bait|null|null|null|null|null|null|bait|prey|-|prey|prey|bait prey|bait|bait|bait|bait|bait|bait|bait|prey|bait|prey|prey|bait|prey|prey|prey|bait|bait|prey|bait|bait|prey|prey|prey|prey|prey|bait|-|bait|bait|prey GNAI2 ITCH MI:0055(fluorescent resonance energy transfer) 23071112 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_219209 bait prey STAM2 ITCH MI:0096(pull down)|MI:0096(pull down) 22275353 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0407(direct interaction) (biogrid)|(biogrid) BIOGRID_195293|BIOGRID_195295 bait|prey prey|bait ARHGEF7 ITCH MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 17652093 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction)|MI:0914(association)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid)|(biogrid) BIOGRID_197203|BIOGRID_197205|BIOGRID_197207|BIOGRID_197204 bait|prey|prey|prey prey|bait|bait|bait c-Jun ITCH MI:0493(in vivo)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 16901904,17110928,19806201,19818398 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) -|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association) MI:0468(hprd)|(biogrid)|(biogrid)|(biogrid) HPRD_31178|BIOGRID_197515|BIOGRID_122973|BIOGRID_183630 -|bait|prey|bait -|prey|bait|prey LAPTM5 ITCH MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 22009753 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (biogrid)|(biogrid) BIOGRID_154816|BIOGRID_154819 prey|prey bait|bait UBAP2 ITCH MI:0004(affinity chromatography technology)|MI:0493(in vivo) 16055720 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|- (biogrid)|MI:0468(hprd) BIOGRID_297870|HPRD_39749 prey|- bait|- POU5F1 ITCH MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 23255053 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid) BIOGRID_247427|BIOGRID_247425|BIOGRID_247424 prey|bait|prey bait|prey|bait DTX1 ITCH MI:0004(affinity chromatography technology)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0493(in vivo)|MI:0004(affinity chromatography technology)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0004(affinity chromatography technology)|MI:0007(anti tag coimmunoprecipitation)|MI:0004(affinity chromatography technology) 17028573,18628966 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0403(colocalization)|MI:0915(physical association)|-|MI:0407(direct interaction)|MI:0403(colocalization)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0403(colocalization)|MI:0403(colocalization) (biogrid)|MI:0471(mint)|MI:0471(mint)|MI:0468(hprd)|(biogrid)|(intact)|(intact)|MI:0471(mint)|(biogrid)|MI:0471(mint)|(biogrid) BIOGRID_201243|MINT_51773|MINT_51771|HPRD_31566|BIOGRID_116796|UniProt_89234|UniProt_89230|MINT_84185|BIOGRID_201244|MINT_84187|BIOGRID_201245 bait|neutral component|prey|-|prey|neutral component|prey|prey|prey|neutral component|prey prey|neutral component|bait|-|bait|neutral component|bait|bait|bait|neutral component|bait SMARCC2 ITCH MI:0493(in vivo)|MI:0004(affinity chromatography technology) 16055720 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) -|MI:0407(direct interaction) MI:0468(hprd)|(biogrid) HPRD_39758|BIOGRID_297858 -|prey -|bait ITCH TOLLIP MI:0004(affinity chromatography technology)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation) 21903422 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0914(association)|MI:0914(association) (biogrid)|(intact)|(intact) BIOGRID_155818|UniProt_172494|UniProt_115752 prey|prey|prey bait|bait|bait GBA ITCH MI:0004(affinity chromatography technology) 23255161 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_247452 prey bait DVL2 ITCH MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 22826439 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid) BIOGRID_198882|BIOGRID_198878|BIOGRID_198876 prey|prey|bait bait|bait|prey BECN1 ITCH MI:0004(affinity chromatography technology) 21936852 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_199174 bait prey ITCH TP63 MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 16908849,20855944,22935697,23370280 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0914(association)|MI:0407(direct interaction)|MI:0914(association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid) BIOGRID_208302|BIOGRID_208303|BIOGRID_197181|BIOGRID_197182|BIOGRID_249552|BIOGRID_139980 bait|bait|bait|bait|prey|bait prey|prey|prey|prey|bait|prey ITCH FBXL15 MI:0018(two hybrid)|MI:0004(affinity chromatography technology) 21572392 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (intact)|(biogrid) UniProt_115328|BIOGRID_258626 bait|bait prey|prey ITCH TXNIP MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 20068034 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid) BIOGRID_198063|BIOGRID_198062|BIOGRID_198061 bait|bait|prey prey|prey|bait ITCH RPAP3 MI:0004(affinity chromatography technology) 16055720 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_297869 bait prey SRC ITCH MI:0004(affinity chromatography technology) 16051665 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_148540 bait prey CUL3 ITCH MI:0004(affinity chromatography technology) 21145461 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_201971 bait prey ELAVL1 ITCH MI:0096(pull down) 19322201 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_186709 bait prey ITCH SNX9 MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down) 20491914 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0914(association)|MI:0914(association)|MI:0914(association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association) MI:0471(mint)|MI:0471(mint)|(intact)|MI:0471(mint)|(biogrid)|MI:0471(mint)|(biogrid)|(intact)|MI:0471(mint)|MI:0471(mint)|(biogrid)|(intact)|(intact)|(intact)|(intact)|(intact)|MI:0471(mint)|MI:0471(mint)|MI:0471(mint)|MI:0471(mint)|MI:0471(mint)|MI:0471(mint)|MI:0471(mint)|(biogrid)|MI:0471(mint) MINT_45892|MINT_76460|UniProt_107433|MINT_45887|BIOGRID_142063|MINT_45886|BIOGRID_142062|UniProt_107437|MINT_45889|MINT_45888|BIOGRID_142060|UniProt_107431|UniProt_107432|UniProt_107436|UniProt_107429|UniProt_107428|MINT_76468|MINT_45900|MINT_76454|MINT_45891|MINT_76459|MINT_76456|MINT_76455|BIOGRID_142059|MINT_76457 prey|prey|prey|prey|prey|bait|bait|prey|prey|prey|prey|bait|prey|bait|prey|bait|bait|bait|bait|bait|bait|prey|prey|bait|prey bait|bait|bait|bait|bait|prey|prey|bait|bait|bait|bait|prey|bait|prey|bait|prey|prey|prey|prey|prey|prey|bait|bait|prey|bait ITCH TRAF6 MI:0004(affinity chromatography technology) 18246070 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_195018 prey bait ITCH TRPV4 MI:0493(in vivo)|MI:0004(affinity chromatography technology) 17110928,20650893 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) -|MI:0915(physical association) MI:0468(hprd)|(biogrid) HPRD_31176|BIOGRID_149750 -|bait -|prey SPG20 ITCH MI:0676(tandem affinity purification)|MI:0018(two hybrid)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0493(in vivo) 16055720,19307600,19580544,19765186,20504295 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0914(association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|- (intact)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|MI:0468(hprd) UniProt_103074|BIOGRID_197097|BIOGRID_148350|BIOGRID_153180|BIOGRID_297868|BIOGRID_153652|HPRD_39749 bait|bait|bait|bait|prey|bait|- prey|prey|prey|prey|bait|prey|- ITCH RNF11 MI:0004(affinity chromatography technology)|MI:0096(pull down)|MI:0047(far western blotting)|MI:0096(pull down)|MI:0096(pull down)|MI:0493(in vivo)|MI:0096(pull down)|MI:0047(far western blotting)|MI:0096(pull down)|MI:0004(affinity chromatography technology)|MI:0096(pull down)|MI:0004(affinity chromatography technology)|MI:0096(pull down) 14559117,19131965,20676133,22507528 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0218(physical interaction)|MI:0407(direct interaction)|MI:0218(physical interaction)|MI:0915(physical association)|-|MI:0218(physical interaction)|MI:0915(physical association)|MI:0218(physical interaction)|MI:0915(physical association)|MI:0218(physical interaction)|MI:0915(physical association)|MI:0218(physical interaction) (biogrid)|MI:0471(mint)|(intact)|MI:0471(mint)|(biogrid)|MI:0468(hprd)|MI:0471(mint)|(intact)|MI:0471(mint)|(biogrid)|MI:0471(mint)|(biogrid)|MI:0471(mint) BIOGRID_201526|MINT_47510|UniProt_108988|MINT_47513|BIOGRID_146536|HPRD_18460|MINT_47515|UniProt_108991|MINT_79387|BIOGRID_116178|MINT_79384|BIOGRID_201125|MINT_79389 bait|bait|bait|prey|prey|-|prey|bait|prey|bait|bait|prey|prey prey|prey|prey|bait|bait|-|bait|prey|bait|prey|prey|bait|bait ITCH SH3GLB1 MI:0004(affinity chromatography technology) 19341794 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_153120 prey bait FYN ITCH MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 16387660 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid) BIOGRID_124877|BIOGRID_124878|BIOGRID_124876 bait|bait|prey prey|prey|bait SGK3 ITCH MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down)|MI:0493(in vivo)|MI:0096(pull down)|MI:0004(affinity chromatography technology)|MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down)|MI:0004(affinity chromatography technology)|MI:0096(pull down)|MI:0096(pull down)|MI:0004(affinity chromatography technology) 16888620 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0217(phosphorylation reaction)|MI:0915(physical association)|MI:0403(colocalization)|MI:0915(physical association)|MI:0403(colocalization)|-|MI:0217(phosphorylation reaction)|MI:0915(physical association)|MI:0403(colocalization)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0217(phosphorylation reaction)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) MI:0471(mint)|(intact)|MI:0471(mint)|(intact)|(intact)|MI:0468(hprd)|MI:0471(mint)|(biogrid)|MI:0471(mint)|MI:0471(mint)|MI:0471(mint)|(intact)|MI:0471(mint)|(intact)|MI:0471(mint)|(biogrid)|MI:0471(mint)|MI:0471(mint)|(biogrid) MINT_51007|UniProt_86693|MINT_51005|UniProt_86695|UniProt_86698|HPRD_31540|MINT_83307|BIOGRID_198055|MINT_83305|MINT_83271|MINT_51006|UniProt_86694|MINT_51004|UniProt_86696|MINT_50983|BIOGRID_198056|MINT_83304|MINT_83306|BIOGRID_198054 neutral component|prey|neutral component|bait|neutral component|-|neutral component|bait|neutral component|prey|bait|bait|bait|neutral component|prey|bait|bait|bait|prey neutral component|bait|neutral component|prey|neutral component|-|neutral component|prey|neutral component|bait|prey|prey|prey|neutral component|bait|prey|prey|prey|bait POLR2B ITCH MI:0004(affinity chromatography technology)|MI:0493(in vivo) 16055720 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|- (biogrid)|MI:0468(hprd) BIOGRID_297854|HPRD_39751 prey|- bait|- KLF10 ITCH MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 18278048 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_200261|BIOGRID_200262 bait|prey prey|bait USP13 ITCH MI:0007(anti tag coimmunoprecipitation)|MI:0004(affinity chromatography technology) 19615732 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (intact)|(biogrid) UniProt_100660|BIOGRID_120705 bait|bait prey|prey SF1 ITCH MI:0004(affinity chromatography technology)|MI:0493(in vivo) 16055720 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|- (biogrid)|MI:0468(hprd) BIOGRID_297866|HPRD_39749 prey|- bait|- UBE2E3 ITCH MI:0415(enzymatic study) 22496338 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_226068 prey bait CAV1 ITCH MI:0096(pull down) 22275353 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_195301 prey bait ITCH SNX18 MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down) 20491914 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) MI:0471(mint)|MI:0471(mint)|(biogrid)|(intact) MINT_45893|MINT_76461|BIOGRID_142064|UniProt_107434 prey|prey|prey|prey bait|bait|bait|bait ARRB2 ITCH MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0493(in vivo) 17947233,18544533 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|- (biogrid)|(biogrid)|(biogrid)|MI:0468(hprd) BIOGRID_117819|BIOGRID_116478|BIOGRID_117821|HPRD_40096 prey|bait|prey|- bait|prey|bait|- YAP1 ITCH MI:0004(affinity chromatography technology) 17110958 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_122150 bait prey ITCH UBE2E2 MI:0018(two hybrid) 19549727 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (intact) UniProt_100842 prey bait ARRDC4 ITCH MI:0428(imaging technique) 23236378 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_248911 bait prey ITCH WWOX MI:0493(in vivo)|MI:0493(in vivo)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0493(in vivo) 16055720,24550385 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) -|-|MI:0915(physical association)|MI:0915(physical association)|- MI:0468(hprd)|MI:0468(hprd)|(biogrid)|(biogrid)|MI:0468(hprd) HPRD_39754|HPRD_39763|BIOGRID_309146|BIOGRID_309338|HPRD_39761 -|-|prey|prey|- -|-|bait|bait|- ITCH NDFIP2 MI:0492(in vitro)|MI:0004(affinity chromatography technology) 15252135,20522958 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) -|MI:0915(physical association) MI:0468(hprd)|(biogrid) HPRD_14779|BIOGRID_148121 -|prey -|bait STAM ITCH MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down) 22275353 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association)|MI:0407(direct interaction) (biogrid)|(biogrid)|(biogrid) BIOGRID_195292|BIOGRID_195300|BIOGRID_195294 bait|prey|prey prey|bait|bait ARID1A ITCH MI:0004(affinity chromatography technology)|MI:0493(in vivo) 16055720 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|- (biogrid)|MI:0468(hprd) BIOGRID_297851|HPRD_39758 prey|- bait|- TAX1BP1 ITCH MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 18246070 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_195014|BIOGRID_195016 prey|bait bait|prey WDR48 ITCH MI:0004(affinity chromatography technology) 22778262 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_199128 prey bait LATS1 ITCH MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 21212414,21383157,23564455 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid) BIOGRID_154359|BIOGRID_305612|BIOGRID_272566|BIOGRID_305613|BIOGRID_305610|BIOGRID_194760|BIOGRID_154357|BIOGRID_154358 prey|prey|prey|prey|bait|bait|bait|prey bait|bait|bait|bait|prey|prey|prey|bait TGFBR1 ITCH MI:0004(affinity chromatography technology) 15350225 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_184040 bait prey NFE2 ITCH MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0415(enzymatic study)|MI:0415(enzymatic study) 11318614,18718448 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0407(direct interaction) (biogrid)|(biogrid)|(biogrid)|(biogrid) BIOGRID_212276|BIOGRID_212275|BIOGRID_116556|BIOGRID_116555 prey|prey|bait|prey bait|bait|prey|bait SMAD3 ITCH MI:0018(two hybrid) 15051726 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_130809 prey bait SMARCC1 ITCH MI:0004(affinity chromatography technology)|MI:0493(in vivo) 16055720 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|- (biogrid)|MI:0468(hprd) BIOGRID_297857|HPRD_39758 prey|- bait|- POLR2A ITCH MI:0004(affinity chromatography technology)|MI:0493(in vivo)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0493(in vivo)|MI:0493(in vivo)|MI:0493(in vivo) 16055720 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|-|MI:0915(physical association)|MI:0407(direct interaction)|-|-|- (biogrid)|MI:0468(hprd)|(biogrid)|(biogrid)|MI:0468(hprd)|MI:0468(hprd)|MI:0468(hprd) BIOGRID_132705|HPRD_31612|BIOGRID_132707|BIOGRID_132713|HPRD_39757|HPRD_39751|HPRD_39753 bait|-|prey|prey|-|-|- prey|-|bait|bait|-|-|- ITCH CYLD MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0004(affinity chromatography technology)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation) 22057290 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid)|(intact)|(intact)|(intact)|(biogrid)|(intact)|(intact) BIOGRID_152853|BIOGRID_152852|UniProt_120639|UniProt_120638|UniProt_120635|BIOGRID_152851|UniProt_120637|UniProt_120636 bait|prey|null|null|bait|bait|prey|bait prey|bait|prey|prey|prey|prey|bait|prey CPSF6 ITCH MI:0493(in vivo)|MI:0493(in vivo)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0493(in vivo)|MI:0004(affinity chromatography technology)|MI:0493(in vivo)|MI:0493(in vivo) 16055720 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) -|-|MI:0915(physical association)|MI:0915(physical association)|-|MI:0407(direct interaction)|-|- MI:0468(hprd)|MI:0468(hprd)|(biogrid)|(biogrid)|MI:0468(hprd)|(biogrid)|MI:0468(hprd)|MI:0468(hprd) HPRD_39763|HPRD_39757|BIOGRID_132709|BIOGRID_132708|HPRD_31611|BIOGRID_132712|HPRD_39753|HPRD_39752 -|-|prey|bait|-|prey|-|- -|-|bait|prey|-|bait|-|- UBE2L3 ITCH MI:0004(affinity chromatography technology)|MI:0096(pull down)|MI:0415(enzymatic study)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0096(pull down)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 15350225,15678106,17038327,17592138,17719543,18718449,20068034,22009753 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0407(direct interaction) (biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid) BIOGRID_225674|BIOGRID_118762|BIOGRID_223181|BIOGRID_225833|BIOGRID_225699|BIOGRID_225744|BIOGRID_221596|BIOGRID_223189 prey|prey|prey|prey|prey|prey|prey|prey bait|bait|bait|bait|bait|bait|bait|bait UBE2K ITCH MI:0415(enzymatic study) 22496338 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_226071 prey bait ARRDC3 ITCH MI:0428(imaging technique)|MI:0428(imaging technique) 23236378 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (biogrid)|(biogrid) BIOGRID_248908|BIOGRID_248902 bait|bait prey|prey SMAD2 ITCH MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 15350225 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (biogrid)|(biogrid) BIOGRID_184038|BIOGRID_184036 bait|prey prey|bait USP12 ITCH MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 22778262 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_199127|BIOGRID_199129 prey|bait bait|prey BID ITCH MI:0004(affinity chromatography technology) 20392206 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_142199 prey bait SCNN1B ITCH MI:0047(far western blotting) 11244092 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_109065 bait prey DVL3 ITCH MI:0004(affinity chromatography technology) 22826439 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_198877 bait prey UBE2D2 ITCH MI:0415(enzymatic study) 22496338 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_226067 prey bait PABPC1 ITCH MI:0493(in vivo)|MI:0004(affinity chromatography technology) 16055720 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) -|MI:0407(direct interaction) MI:0468(hprd)|(biogrid) HPRD_39749|BIOGRID_297865 -|prey -|bait NOTCH1 ITCH MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0493(in vivo) 10940313,12682059,23886940 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|- (biogrid)|(biogrid)|(biogrid)|MI:0468(hprd) BIOGRID_283804|BIOGRID_137961|BIOGRID_137962|HPRD_4291 prey|bait|prey|- bait|prey|bait|- MAPK8 ITCH MI:0415(enzymatic study)|MI:0415(enzymatic study) 16446428 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_198814|BIOGRID_198815 bait|bait prey|prey GCA ITCH MI:0004(affinity chromatography technology) 23255161 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_247453 bait prey ERBB4 ITCH MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation)|MI:0047(far western blotting)|MI:0004(affinity chromatography technology)|MI:0047(far western blotting)|MI:0047(far western blotting) 17463226,18334649 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0407(direct interaction) (biogrid)|(biogrid)|MI:0465(dip)|MI:0465(dip)|(biogrid)|(biogrid)|(biogrid)|(biogrid) BIOGRID_117236|BIOGRID_117235|DIP_53952|DIP_53955|BIOGRID_121726|BIOGRID_117237|BIOGRID_121724|BIOGRID_121723 prey|bait|-|-|prey|prey|prey|prey bait|prey|-|-|bait|bait|bait|bait UBE2G1 ITCH MI:0415(enzymatic study)|MI:0004(affinity chromatography technology) 16446428,22826439 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0407(direct interaction) (biogrid)|(biogrid) BIOGRID_225844|BIOGRID_225853 prey|prey bait|bait RIPK1 ITCH MI:0004(affinity chromatography technology)|MI:0493(in vivo) 19131965 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|- (biogrid)|MI:0468(hprd) BIOGRID_116177|HPRD_33370 prey|- bait|- ITCH LITAF MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 21326863 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_201415|BIOGRID_201414 bait|bait prey|prey ITCH RASSF5 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 23538446 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_272671|BIOGRID_272669 prey|bait bait|prey ITCH SH3GL2 MI:0493(in vivo)|MI:0004(affinity chromatography technology)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0428(imaging technique)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0428(imaging technique)|MI:0428(imaging technique) 14684745 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) -|MI:0915(physical association)|MI:0220(ubiquitination reaction)|MI:0220(ubiquitination reaction)|MI:0403(colocalization)|MI:0403(colocalization)|MI:0220(ubiquitination reaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0403(colocalization)|MI:0915(physical association) MI:0468(hprd)|(biogrid)|MI:0471(mint)|MI:0471(mint)|MI:0471(mint)|MI:0471(mint)|(intact)|MI:0471(mint)|MI:0471(mint)|(intact)|(intact) HPRD_13065|BIOGRID_132804|MINT_81017|MINT_49178|MINT_81015|MINT_49176|UniProt_74144|MINT_49175|MINT_81014|UniProt_74142|UniProt_74143 -|prey|unspecified role|unspecified role|unspecified role|unspecified role|unspecified role|bait|bait|unspecified role|bait -|bait|unspecified role|unspecified role|unspecified role|unspecified role|unspecified role|prey|prey|unspecified role|prey p53 ITCH MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 18559494,21474069 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid) BIOGRID_140785|BIOGRID_117061|BIOGRID_140783 prey|bait|bait bait|prey|prey NUMB ITCH MI:0096(pull down)|MI:0096(pull down)|MI:0004(affinity chromatography technology)|MI:0493(in vivo)|MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down) 12682059,18628966,20818436 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|-|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid)|MI:0468(hprd)|(biogrid)|(biogrid)|(biogrid) BIOGRID_89690|BIOGRID_153378|BIOGRID_116795|HPRD_12624|BIOGRID_89688|BIOGRID_153367|BIOGRID_89689 prey|bait|prey|-|prey|prey|bait bait|prey|bait|-|bait|bait|prey UBE2E1 ITCH MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 15350225,19737936 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0407(direct interaction) (biogrid)|(biogrid) BIOGRID_226084|BIOGRID_223190 prey|prey bait|bait CBL ITCH MI:0018(two hybrid)|MI:0492(in vitro)|MI:0018(two hybrid)|MI:0004(affinity chromatography technology)|MI:0018(two hybrid) 12226085,19341794 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|-|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (intact)|MI:0468(hprd)|MI:0471(mint)|(biogrid)|MI:0471(mint) UniProt_71063|HPRD_26014|MINT_31057|BIOGRID_153119|MINT_59605 bait|-|bait|prey|bait prey|-|prey|bait|prey SMARCE1 ITCH MI:0004(affinity chromatography technology)|MI:0493(in vivo)|MI:0493(in vivo) 16055720 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|-|- (biogrid)|MI:0468(hprd)|MI:0468(hprd) BIOGRID_297859|HPRD_39758|HPRD_39749 prey|-|- bait|-|- URI1 ITCH MI:0004(affinity chromatography technology)|MI:0493(in vivo) 16055720 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|- (biogrid)|MI:0468(hprd) BIOGRID_297852|HPRD_39751 prey|- bait|- SMAD7 ITCH MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 15946939,22773947 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid) BIOGRID_197924|BIOGRID_127579|BIOGRID_127578 bait|prey|bait prey|bait|prey MLANA ITCH MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down) 15703212,20491914 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association)|MI:0914(association)|MI:0914(association)|MI:0914(association) (biogrid)|(biogrid)|MI:0471(mint)|(intact)|MI:0471(mint) BIOGRID_129226|BIOGRID_129224|MINT_45890|UniProt_107430|MINT_76458 bait|bait|bait|bait|bait prey|prey|prey|prey|prey CXCR4 ITCH MI:0004(affinity chromatography technology)|MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down) 19116316,22275353,24489825 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction)|MI:0403(colocalization)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0407(direct interaction) (biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid) BIOGRID_305637|BIOGRID_116209|BIOGRID_195297|BIOGRID_116207|BIOGRID_116208|BIOGRID_116206 bait|prey|bait|bait|bait|bait prey|bait|prey|prey|prey|prey WASL ITCH MI:0663(confocal microscopy) 23414517 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (intact) UniProt_127572 bait prey MAP2K4 ITCH MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 19737936 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association)|MI:0407(direct interaction) (biogrid)|(biogrid)|(biogrid) BIOGRID_148420|BIOGRID_148417|BIOGRID_148418 prey|bait|prey bait|prey|bait CPSF7 ITCH MI:0004(affinity chromatography technology)|MI:0493(in vivo) 16055720 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|- (biogrid)|MI:0468(hprd) BIOGRID_297864|HPRD_39749 prey|- bait|- ITCH CBLC MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0492(in vitro)|MI:0018(two hybrid) 12226085 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0403(colocalization)|MI:0915(physical association)|MI:0915(physical association)|MI:0403(colocalization)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0403(colocalization)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|-|MI:0915(physical association) (intact)|MI:0471(mint)|(intact)|MI:0471(mint)|MI:0471(mint)|MI:0471(mint)|(intact)|(biogrid)|(biogrid)|(intact)|(intact)|(intact)|(biogrid)|(intact)|MI:0471(mint)|MI:0471(mint)|MI:0471(mint)|MI:0471(mint)|(biogrid)|MI:0471(mint)|MI:0468(hprd)|MI:0471(mint) 215022|MINT_59608|UniProt_71059|MINT_59607|MINT_59604|MINT_59603|UniProt_71060|BIOGRID_134355|BIOGRID_134356|UniProt_71061|UniProt_71062|UniProt_1301|BIOGRID_134354|UniProt_71064|MINT_59573|MINT_31059|MINT_31058|MINT_31046|BIOGRID_134357|MINT_31055|HPRD_26013|MINT_31056 prey|bait|prey|unspecified role|bait|prey|unspecified role|prey|prey|bait|prey|prey|prey|bait|prey|bait|unspecified role|prey|bait|prey|-|bait bait|prey|bait|unspecified role|prey|bait|unspecified role|bait|bait|prey|bait|bait|bait|prey|bait|prey|unspecified role|bait|prey|bait|-|prey NEDD9 ITCH MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0006(anti bait coimmunoprecipitation)|MI:0493(in vivo)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 15051726 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0220(ubiquitination reaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0220(ubiquitination reaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0915(physical association)|-|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid)|MI:0471(mint)|MI:0471(mint)|MI:0471(mint)|MI:0471(mint)|MI:0471(mint)|MI:0471(mint)|MI:0471(mint)|(intact)|(biogrid)|(biogrid)|MI:0471(mint)|MI:0468(hprd)|(intact)|(intact)|(biogrid) BIOGRID_130808|BIOGRID_86779|BIOGRID_78068|MINT_58003|MINT_55287|MINT_58002|MINT_55288|MINT_58001|MINT_55289|MINT_58000|UniProt_77540|BIOGRID_86780|BIOGRID_86782|MINT_55286|HPRD_14778|UniProt_77538|UniProt_77539|BIOGRID_130810 prey|bait|bait|bait|bait|bait|bait|bait|bait|bait|bait|bait|prey|bait|-|bait|bait|prey bait|prey|prey|unspecified role|prey|prey|prey|prey|unspecified role|prey|prey|prey|bait|prey|-|prey|prey|bait UBAP2L ITCH MI:0493(in vivo)|MI:0004(affinity chromatography technology)|MI:0493(in vivo)|MI:0493(in vivo)|MI:0493(in vivo) 16055720 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) -|MI:0407(direct interaction)|-|-|- MI:0468(hprd)|(biogrid)|MI:0468(hprd)|MI:0468(hprd)|MI:0468(hprd) HPRD_39759|BIOGRID_132716|HPRD_39757|HPRD_39756|HPRD_39749 -|prey|-|-|- -|bait|-|-|- ADRB2 ITCH MI:0428(imaging technique)|MI:0493(in vivo) 18544533,23236378 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|- (biogrid)|MI:0468(hprd) BIOGRID_248914|HPRD_40096 bait|- prey|- UBC ITCH MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0686(unspecified method)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0415(enzymatic study)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0096(pull down)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0415(enzymatic study)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0096(pull down)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0096(pull down)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0114(x-ray crystallography)|MI:0096(pull down)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0096(pull down)|MI:0004(affinity chromatography technology)|MI:0096(pull down)|MI:0004(affinity chromatography technology) 10,17013377,17038327,17719543,19341794,19343052,19808964,20484045,20504295,20639865,20818436,20972266,21139048,21572392,21890473,21906983,21963094,21987572,22053931,22496338,22505724,23000965,23287719,23564455,23644597,24101513 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0914(association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0914(association)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0914(association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0914(association)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|MI:0471(mint)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(intact)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|MI:0471(mint)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(intact)|(biogrid) BIOGRID_171625|BIOGRID_153301|BIOGRID_293640|BIOGRID_249569|BIOGRID_258633|BIOGRID_272563|BIOGRID_211525|BIOGRID_180788|BIOGRID_153653|BIOGRID_272560|MINT_41479|BIOGRID_264736|BIOGRID_145095|BIOGRID_162947|BIOGRID_176453|BIOGRID_160082|BIOGRID_141981|BIOGRID_225294|UniProt_183935|BIOGRID_153117|BIOGRID_153116|BIOGRID_118767|BIOGRID_153553|BIOGRID_164200|BIOGRID_281004|MINT_71089|BIOGRID_122322|BIOGRID_222148|BIOGRID_153368|BIOGRID_268467|UniProt_99925|BIOGRID_122323 bait|bait|bait|prey|prey|prey|prey|bait|prey|bait|bait|bait|prey|bait|bait|bait|prey|bait|bait|bait|prey|prey|prey|bait|prey|bait|prey|bait|prey|bait|bait|bait prey|prey|prey|bait|bait|bait|bait|prey|bait|prey|null|prey|bait|prey|prey|prey|bait|prey|null|prey|bait|bait|bait|prey|bait|null|bait|prey|bait|prey|null|prey ITCH TRPC4 MI:0493(in vivo) 17110928 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) - MI:0468(hprd) HPRD_31179 - - CFLAR ITCH MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 18559494,19090833,19808964,21474069 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid) BIOGRID_153555|BIOGRID_153554|BIOGRID_221427|BIOGRID_117060|BIOGRID_140784|BIOGRID_140781 bait|prey|prey|bait|prey|bait prey|bait|bait|prey|bait|prey ATN1 ITCH MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 9647693 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0407(direct interaction)|- (biogrid)|(biogrid)|MI:0468(hprd) BIOGRID_114707|BIOGRID_114714|HPRD_14245 bait|prey|- prey|bait|- UBE2D3 ITCH MI:0114(x-ray crystallography) 23644597 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_281009 bait prey EWSR1 ITCH MI:0004(affinity chromatography technology) 16055720 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_297853 prey bait MGRN1 ITCH MI:0004(affinity chromatography technology) 23253940 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_247745 bait prey SFN ITCH MI:0676(tandem affinity purification)|MI:0676(tandem affinity purification)|MI:0004(affinity chromatography technology)|MI:0676(tandem affinity purification) 15778465 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) MI:0471(mint)|MI:0471(mint)|(biogrid)|(intact) MINT_84508|MINT_52045|BIOGRID_84953|UniProt_81339 bait|bait|bait|bait null|null|prey|null POLR2E ITCH MI:0493(in vivo)|MI:0004(affinity chromatography technology) 16055720 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) -|MI:0407(direct interaction) MI:0468(hprd)|(biogrid) HPRD_39751|BIOGRID_297856 -|prey -|bait RPAP2 ITCH MI:0004(affinity chromatography technology) 16055720 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_297861 prey bait TRPV1 ITCH MI:0493(in vivo) 17110928 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) - MI:0468(hprd) HPRD_31180 - - CSNK2A1 ITCH MI:0686(unspecified method) 17437719 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_197416 bait prey DVL1 ITCH MI:0004(affinity chromatography technology) 22826439 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_198875 bait prey WBP2 ITCH MI:0004(affinity chromatography technology) 16055720 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_297871 prey bait GLI1 ITCH MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down) 20818436 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association) (intact)|(intact)|(intact)|(intact)|(biogrid)|(biogrid)|(intact)|(biogrid)|(biogrid)|(intact)|(intact)|(biogrid)|(intact) UniProt_108838|UniProt_108835|UniProt_108834|UniProt_108837|BIOGRID_153370|BIOGRID_153371|UniProt_172953|BIOGRID_153369|BIOGRID_153373|UniProt_172957|UniProt_172954|BIOGRID_153374|UniProt_172958 prey|prey|prey|bait|bait|prey|prey|bait|prey|bait|prey|prey|prey bait|bait|bait|prey|prey|bait|bait|prey|bait|prey|bait|bait|bait ITCH PI4K2A MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down) 23146885 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0403(colocalization)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (intact)|(intact)|(intact)|(intact)|(intact)|(intact)|(intact)|(intact)|(intact)|(intact)|(intact) UniProt_185750|UniProt_175491|UniProt_175490|UniProt_125990|UniProt_175489|UniProt_125991|UniProt_125987|UniProt_125988|UniProt_185749|UniProt_185748|UniProt_125989 bait|bait|bait|neutral component|bait|neutral component|bait|bait|bait|bait|bait prey|prey|prey|neutral component|prey|neutral component|prey|prey|prey|prey|prey PCBP2 ITCH MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 19881509 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_195926|BIOGRID_195924 bait|prey prey|bait ITCH HNRNPUL1 MI:0004(affinity chromatography technology) 16055720 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_297863 bait prey POLR2C ITCH MI:0004(affinity chromatography technology)|MI:0493(in vivo) 16055720 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|- (biogrid)|MI:0468(hprd) BIOGRID_297855|HPRD_39751 prey|- bait|- MDM2 ITCH MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 21093410 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_213549|BIOGRID_213548 prey|bait bait|prey AMOT ITCH MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 22385262,23564455,24101513 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid) BIOGRID_293638|BIOGRID_272557|BIOGRID_185347|BIOGRID_272559|BIOGRID_185346 prey|prey|prey|bait|bait bait|bait|bait|prey|prey SCNN1A ITCH MI:0047(far western blotting) 11244092 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_109061 bait prey OCLN ITCH MI:0004(affinity chromatography technology)|MI:0493(in vivo) 11782481,19478092 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|- (biogrid)|MI:0468(hprd) BIOGRID_140520|HPRD_11604 bait|- prey|- TNFRSF10B ITCH MI:0004(affinity chromatography technology) 19808964 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_153556 bait prey HGS ITCH MI:0004(affinity chromatography technology) 14602072 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_132854 bait prey ARRDC1 ITCH MI:0096(pull down)|MI:0004(affinity chromatography technology)|MI:0428(imaging technique) 21191027,23236378,23886940 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0407(direct interaction) (biogrid)|(biogrid)|(biogrid) BIOGRID_160737|BIOGRID_283807|BIOGRID_248900 bait|prey|bait prey|bait|prey HNRNPL ITCH MI:0004(affinity chromatography technology) 16055720 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_297862 prey bait

PPI - HINT Gene A Gene B PMID Method Quality DVL2 ITCH 26701932,26701932,22826439,22826439 0004,0428,0415,0004 LC HGS ITCH 26508657,14602072 0004,0004 LC SMAD7 ITCH 15946939,15946939,22773947 0004,0007,0004 LC LDLRAD4 ITCH 26186194 0004 HT TP73 ITCH 15678106,15678106,15678106,15678106,15678106,15678106,15678106,17592138,15678106,17110958 0045,0415,0084,0096,0007,0006,0019,0096,0004,0004 LC CFLAR ITCH 21474069,18559494,19808964 0004,0004,0004 LC SMAD6 ITCH 24850914,15946939 0004,0007 LC USP12 ITCH 22778262,26811477 0004,1313 LC GRAP2 ITCH 26186194 0004 HT LATS1 ITCH 21383157,21212414,21383157,21383157,23564455,21212414 0096,0004,0415,0004,0004,0096 LC TP53 ITCH 16908849,21474069,18559494 0006,0004,0004 LC JUN ITCH 19818398,16901904,19806201 0004,0096,0004 LC UBC ITCH 20972266,20504295,19341794,20818436,19343052,20639865,19343052,17013377,17719543,17038327,17592138,19808964,20484045 0004,0004,0004,0004,0004,0004,0096,0004,0096,0004,0007,0004,0004 LC CBL ITCH 12226085,19341794 0007,0004 LC POLR2A ITCH 16055720,26508657,16055720 0004,0004,0096 LC ARRB2 ITCH 17947233,18544533,17947233 0096,0004,0004 LC NOTCH1 ITCH 10940313,23886940 0004,0004 LC ARRB1 ITCH 17947233,18544533,17947233 0007,0004,0004 LC NUMB ITCH 12682059,20818436,18628966,12682059,20818436 0004,0096,0096,0096,0004 LC UBE2E1 ITCH 19737936,15350225 0096,0096 LC CXCR4 ITCH 22275353,24489825,19116316,19116316,19116316 0401,0004,0055,0004,0096 LC UBE2D3 ITCH 23644597,25723849 0096,0096 LC UBE2G1 ITCH 22826439,16446428 0096,0096 LC UBE2D2 ITCH 26245901,11724934,22496338,25723849 0096,0096,0096,0096 LC GRB2 ITCH 26344197 0401 HT UBE2L3 ITCH 26245901,17996703,15350225,25723849,17592138,17719543,26245901,20068034,25632008,18718449,17038327,22009753,15678106,26949039 0096,0096,0096,0096,0096,0096,0415,0096,0004,0096,0004,0096,0096,0096 LC MDM2 ITCH 21093410,26025930 0004,0004 LC RIPK1 ITCH 18246070,19131965 0007,0004 LC CUL3 ITCH 21145461 0004 HT ARHGEF7 ITCH 17652093,17652093,17652093,26613292 0004,0114,0096,0096 LC ERBB4 ITCH 18334649,17463226,17463226,17463226,18334649,18334649,17463226,18334649,17463226,17463226 0096,0004,0007,0018,0004,0007,0047,0006,0096,0892 LC CPSF6 ITCH 16055720,16055720,26508657,16055720,16055720 0047,0096,0004,0019,0004 LC MLANA ITCH 20491914,15703212,15703212,15703212 0096,0096,0004,0007 LC AMOT ITCH 24101513,22385262,23564455 0004,0004,0004 LC Q53GA5 ITCH 21474069,18559494 0004,0004 LC Q59F61 ITCH 19090833,21474069,18559494,19808964 0004,0004,0004,0004 LC TMEM92 ITCH 26186194 0004 HT Q7Z4S8 ITCH 26186194 0004 HT DTX1 ITCH 18628966,17028573,17028573,17028573 0096,0428,0004,0007 LC SPG20 ITCH 16055720,19765186,20504295,16055720,19580544,19765186 0096,0004,0004,0004,0004,0676 LC ARRDC1 ITCH 26186194,23886940 0004,0096 HT,LC Q8WU02 ITCH 26186194 0004 HT TMEM171 ITCH 26186194 0004 HT STAM ITCH 22275353,26508657,22275353 0004,0004,0096 LC USP13 ITCH 19615732,19615732 0004,0007 HT USP9X ITCH 17038327,17038327,26508657,17038327,19341794,17038327 0096,0004,0004,0069,0004,0019 LC WBP2 ITCH 16055720,26508657,16055720 0004,0004,0096 LC PLEKHB2 ITCH 26186194 0004 HT WBP1 ITCH 26186194 0004 HT ITCH ITCH 16055720,18718449,16055720,18718449 0096,0415,0004,0004 LC ITCH LITAF 21326863,21326863,25963657 0055,0004,0004 LC ITCH SH3GL2 14684745,26613292,14684745,26613292,26613292,26613292,14684745,14684745 0007,0055,0004,0004,0047,0096,0428,0045 LC ITCH NDFIP1 26245901,25632008 0096,0004 LC ITCH TP63 16908849,22935697,23370280,20855944,20855944,22935697,16908849,16908849,25485500 0004,0114,0004,0096,0114,0096,0006,0007,0096 LC ITCH TXNIP 26527736,20068034,26527736,20068034 0096,0415,0114,0004 LC ITCH TMEM51 26186194 0004 HT ITCH WWOX 25331887,24550385 0004,0004 LC ITCH RNF11 14559117,20676133,22507528,20676133,20676133,19131965 0004,0004,0004,0007,0096,0004 LC ITCH Q9Y6J7 26186194 0004 HT LDLRAD4 ITCH 26186194 0004 HT GRAP2 ITCH 26186194 0004 HT GRB2 ITCH 26344197 0401 HT CUL3 ITCH 21145461 0004 HT TMEM92 ITCH 26186194 0004 HT Q7Z4S8 ITCH 26186194 0004 HT ARRDC1 ITCH 26186194 0004 HT Q8WU02 ITCH 26186194 0004 HT TMEM171 ITCH 26186194 0004 HT USP13 ITCH 19615732,19615732 0004,0007 HT PLEKHB2 ITCH 26186194 0004 HT WBP1 ITCH 26186194 0004 HT ITCH TMEM51 26186194 0004 HT ITCH Q9Y6J7 26186194 0004 HT DVL2 ITCH 26701932,26701932,22826439,22826439 0004,0428,0415,0004 LC HGS ITCH 26508657,14602072 0004,0004 LC SMAD7 ITCH 15946939,15946939,22773947 0004,0007,0004 LC TP73 ITCH 15678106,15678106,15678106,15678106,15678106,15678106,15678106,17592138,15678106,17110958 0045,0415,0084,0096,0007,0006,0019,0096,0004,0004 LC CFLAR ITCH 21474069,18559494,19808964 0004,0004,0004 LC SMAD6 ITCH 24850914,15946939 0004,0007 LC USP12 ITCH 22778262,26811477 0004,1313 LC LATS1 ITCH 21383157,21212414,21383157,21383157,23564455,21212414 0096,0004,0415,0004,0004,0096 LC TP53 ITCH 16908849,21474069,18559494 0006,0004,0004 LC JUN ITCH 19818398,16901904,19806201 0004,0096,0004 LC UBC ITCH 20972266,20504295,19341794,20818436,19343052,20639865,19343052,17013377,17719543,17038327,17592138,19808964,20484045 0004,0004,0004,0004,0004,0004,0096,0004,0096,0004,0007,0004,0004 LC CBL ITCH 12226085,19341794 0007,0004 LC POLR2A ITCH 16055720,26508657,16055720 0004,0004,0096 LC ARRB2 ITCH 17947233,18544533,17947233 0096,0004,0004 LC NOTCH1 ITCH 10940313,23886940 0004,0004 LC ARRB1 ITCH 17947233,18544533,17947233 0007,0004,0004 LC NUMB ITCH 12682059,20818436,18628966,12682059,20818436 0004,0096,0096,0096,0004 LC UBE2E1 ITCH 19737936,15350225 0096,0096 LC CXCR4 ITCH 22275353,24489825,19116316,19116316,19116316 0401,0004,0055,0004,0096 LC UBE2D3 ITCH 23644597,25723849 0096,0096 LC UBE2G1 ITCH 22826439,16446428 0096,0096 LC UBE2D2 ITCH 26245901,11724934,22496338,25723849 0096,0096,0096,0096 LC UBE2L3 ITCH 26245901,17996703,15350225,25723849,17592138,17719543,26245901,20068034,25632008,18718449,17038327,22009753,15678106,26949039 0096,0096,0096,0096,0096,0096,0415,0096,0004,0096,0004,0096,0096,0096 LC MDM2 ITCH 21093410,26025930 0004,0004 LC RIPK1 ITCH 18246070,19131965 0007,0004 LC ARHGEF7 ITCH 17652093,17652093,17652093,26613292 0004,0114,0096,0096 LC ERBB4 ITCH 18334649,17463226,17463226,17463226,18334649,18334649,17463226,18334649,17463226,17463226 0096,0004,0007,0018,0004,0007,0047,0006,0096,0892 LC CPSF6 ITCH 16055720,16055720,26508657,16055720,16055720 0047,0096,0004,0019,0004 LC MLANA ITCH 20491914,15703212,15703212,15703212 0096,0096,0004,0007 LC AMOT ITCH 24101513,22385262,23564455 0004,0004,0004 LC Q53GA5 ITCH 21474069,18559494 0004,0004 LC Q59F61 ITCH 19090833,21474069,18559494,19808964 0004,0004,0004,0004 LC DTX1 ITCH 18628966,17028573,17028573,17028573 0096,0428,0004,0007 LC SPG20 ITCH 16055720,19765186,20504295,16055720,19580544,19765186 0096,0004,0004,0004,0004,0676 LC ARRDC1 ITCH 23886940 0096 LC STAM ITCH 22275353,26508657,22275353 0004,0004,0096 LC USP9X ITCH 17038327,17038327,26508657,17038327,19341794,17038327 0096,0004,0004,0069,0004,0019 LC WBP2 ITCH 16055720,26508657,16055720 0004,0004,0096 LC ITCH ITCH 16055720,18718449,16055720,18718449 0096,0415,0004,0004 LC ITCH LITAF 21326863,21326863,25963657 0055,0004,0004 LC ITCH SH3GL2 14684745,26613292,14684745,26613292,26613292,26613292,14684745,14684745 0007,0055,0004,0004,0047,0096,0428,0045 LC ITCH NDFIP1 26245901,25632008 0096,0004 LC ITCH TP63 16908849,22935697,23370280,20855944,20855944,22935697,16908849,16908849,25485500 0004,0114,0004,0096,0114,0096,0006,0007,0096 LC ITCH TXNIP 26527736,20068034,26527736,20068034 0096,0415,0114,0004 LC ITCH WWOX 25331887,24550385 0004,0004 LC ITCH RNF11 14559117,20676133,22507528,20676133,20676133,19131965 0004,0004,0004,0007,0096,0004 LC WASL ITCH 23414517 0399 HT BIN1 ITCH 26613292,26613292,26613292 0004,0047,0055 LC DVL2 ITCH 22826439,22826439 0415,0004 LC TP73 ITCH 15678106,15678106,15678106,15678106,15678106,15678106,15678106,15678106 0045,0415,0084,0096,0007,0006,0019,0004 LC LATS1 ITCH 21383157,21383157,21383157 0096,0415,0004 LC GLI1 ITCH 20818436,20818436,20818436,20818436 0096,0415,0007,0004 LC UBB ITCH 17719543 0415 LC UBC ITCH 22496338,25723849,26949039,23644597 0415,0415,0114,0415 LC PRKACA ITCH 17437719 0415 LC SCNN1A ITCH 11244092 0047 LC MAPK8 ITCH 16446428,16446428 0004,0415 LC MAP2K4 ITCH 19737936,19737936,19737936 0096,0415,0004 LC SCNN1B ITCH 11244092 0047 LC ATN1 ITCH 9647693,9647693 0096,0018 LC CXCR4 ITCH 22275353,19116316,19116316,19116316 0401,0055,0004,0096 LC GRB2 ITCH 26344197 0401 LC UBE2L3 ITCH 26245901,26245901 0096,0415 LC CSNK2A1 ITCH 17437719 0415 LC POU5F1 ITCH 19997087,23255053,23255053 0415,0004,0415 LC LAPTM5 ITCH 22009753,22009753 0415,0004 LC ARHGEF7 ITCH 17652093,17652093,17652093 0004,0114,0096 LC UBAP2L ITCH 16055720,16055720,16055720 0004,0047,0096 LC BECN1 ITCH 21936852 0018 LC NEDD9 ITCH 15051726,15051726,15051726,15051726 0096,0018,0006,0004 LC ERBB4 ITCH 17463226,17463226,17463226,17463226,17463226,17463226 0004,0007,0018,0047,0096,0892 LC SMAD2 ITCH 15350225,15350225 0004,0415 LC ITSN1 ITCH 26613292,26613292 0004,0055 LC NFE2 ITCH 18718448,18718448,11318614,11318614 0415,0004,0047,0018 LC OCLN ITCH 11782481 0018 LC CPSF6 ITCH 16055720,16055720,16055720,16055720 0047,0096,0019,0004 LC LRRK1 ITCH 24947832 0089 LC DKFZP781N0293 ITCH 16888620,16888620 0004,0415 LC SPG20 ITCH 19307600 0018 LC ARRDC1 ITCH 21191027,23236378 0018,0018 LC USP9X ITCH 17038327,17038327,17038327,17038327 0096,0004,0069,0019 LC ARRDC3 ITCH 23236378,23236378,23236378 0018,0007,0004 LC SGK3 ITCH 16888620,16888620,16888620,16888620,16888620,16888620,16888620 0018,0424,0007,0416,0415,0096,0004 LC ITCH ITCH 17592138,22496338,18718449,19997087,16446428,PDB_5DZD,11724934,PDB_5DWS,24790097,17038327,23146885,26949039,17719543,18718449,17996703 0415,0415,0415,0415,0415,0114,0415,0114,0415,0415,0415,0415,0415,0004,0415 LC ITCH UBE2E2 19549727 0018 HT ITCH LITAF 21326863,21326863 0055,0004 LC ITCH SH3GL2 14684745,26613292,14684745,26613292,26613292,26613292,14684745,14737190,14684745 0007,0055,0004,0004,0047,0096,0428,0045,0045 LC,HT ITCH PI4K2A 23146885,23146885,23146885 0077,0416,0096 LC ITCH PACSIN1 26613292,26613292,26613292,26613292 0004,0047,0055,0096 LC ITCH TP63 22935697,20855944,20855944,22935697 0114,0096,0114,0096 LC ITCH TXNIP PDB_4ROF,26527736,20068034,PDB_5DZD,26527736,20068034 0114,0096,0415,0114,0114,0004 LC ITCH CBLC 12226085,12226085,12226085,12226085,12226085,12226085 0007,0416,0021,0018,0096,0004 LC ITCH SNX9 20491914,20491914,20491914,20491914,20491914 0415,0096,0006,0004,0007 LC ITCH W0FFG4 21936852 0018 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q96J02 O14640 ITCH DVL1 0.21 22826439 Q96J02 O14763 ITCH TNFRSF10B 0.21 19808964 Q96J02 O14920 ITCH IKBKB 0.21 26603838 Q96J02 Q5JRV8 ITCH TMEM255A 0.126 26186194 Q96J02 O43318 ITCH MAP3K7 0.21 25632008 Q96J02 O43541 ITCH SMAD6 0.21 24850914 Q96J02 O15165 ITCH LDLRAD4 0.126 26186194 Q96J02 O35179 ITCH SH3GL2 0.21 14684745 Q96J02 P24928 ITCH POLR2A 0.454 26508657,16055720 Q96J02 O35182 ITCH SMAD6 0.126 23455153 Q96J02 O60291 ITCH MGRN1 0.21 23253940 Q96J02 Q8R0W6 ITCH NDFIP1 0.21 11748237 Q9NQC7 Q96J02 CYLD ITCH 0.569 22057290 Q9NV92 Q96J02 NDFIP2 ITCH 0.21 20522958 Q9NW97 Q96J02 TMEM51 ITCH 0.126 26186194 Q9NZ52 Q96J02 GGA3 ITCH 0.21 25195858 Q9H3M7 Q96J02 TXNIP ITCH 0.794 26527736,20068034 Q9Y371 Q96J02 SH3GLB1 ITCH 0.21 19341794 Q9Y4K3 Q96J02 TRAF6 ITCH 0.21 18246070 Q96J02 O75791 ITCH GRAP2 0.126 26186194 Q96J02 Q6UXU6 ITCH TMEM92 0.126 26186194 Q96J02 P0CG47 ITCH UBB 0.033 17719543 Q96J02 P0CG48 ITCH UBC 0.82 23644597,19343052,23287719,25723849,22496338 Q96J02 Q86Y01 ITCH DTX1 0.702 17028573,18628966 Q96J02 Q86YD5 ITCH LDLRAD3 0.21 26854353 Q96J02 P04899 ITCH GNAI2 0.309 23071112 Q96J02 P06396 ITCH GSN 0.21 25246592 Q96J02 P08151 ITCH GLI1 0.794 20818436 Q9NZC7 Q96J02 WWOX ITCH 0.309 24550385,25331887 Q96J02 Q8NCT1 ITCH ARRDC4 0.376 23236378 Q96J02 P04601 ITCH NEF 0.454 23071112 Q9Y3C5 Q96J02 RNF11 ITCH 0.61 14559117,19131965,20676133,22507528 Q96J02 Q92995 ITCH USP13 0.236 19615732 Q96J02 O43809 ITCH NUDT21 0.286 16055720 Q96J02 Q00987 ITCH MDM2 0.61 26025930,21093410 Q96J02 O75113 ITCH N4BP1 0.454 17592138 Q96J02 P22681 ITCH CBL 0.376 12226085,19341794 Q96J02 P51965 ITCH UBE2E1 0.523 15350225,19737936 Q96J02 P62253 ITCH UBE2G1 0.523 22826439,16446428 Q96J02 Q13571 ITCH LAPTM5 0.454 22009753 Q96J02 Q15811 ITCH ITSN1 0.454 26613292 Q9BTU6 Q96J02 PI4K2A ITCH 0.623 23146885 Q96J02 P13285 ITCH LMP2 0.396 17174309,22810586 Q96J02 P07550 ITCH ADRB2 0.376 23236378 Q9H0E2 Q96J02 TOLLIP ITCH 0.236 21903422 Q96J02 Q15303 ITCH ERBB4 0.937 17463226,18334649 Q9H3D4 Q96J02 TP63 ITCH 0.902 20855944,25485500,22935697,23370280,16908849 Q9EPK8 Q96J02 TRPV4 ITCH 0.309 17110928 Q96J02 P70444 ITCH BID 0.376 20392206 Q96J02 Q4VCS5 ITCH AMOT 0.692 22385262,23564455,24101513 Q96J02 P45983 ITCH MAPK8 0.454 16446428 Q96J02 P31947 ITCH SFN 0.236 15778465 Q96J02 P49757 ITCH NUMB 0.837 12682059,20818436,18628966 Q96J02 O15519 ITCH CFLAR 0.757 19090833,18559494,19808964,21474069 Q96J02 Q16655 ITCH MLANA 0.569 15703212,20491914 Q96J02 Q13625 ITCH TP53BP2 0.814 25436413 Q96J02 O14641 ITCH DVL2 0.765 26701932,22826439 Q96J02 O95835 ITCH LATS1 0.911 21212414,21383157,23564455 Q96J02 O00499 ITCH BIN1 0.623 26613292 Q9ULV8 Q96J02 CBLC ITCH 0.888 12226085 Q99962 Q96J02 SH3GL2 ITCH 0.891 26613292,14684745 Q96J02 Q14511 ITCH NEDD9 0.939 15051726 Q96J02 Q96BR1 ITCH SGK3 0.843 16888620 Q9Y5X1 Q96J02 SNX9 ITCH 0.92 20491914 Q96J02 P62837 ITCH UBE2D2 0.772 26245901,25723849,22496338,11724934 Q96J02 Q93008 ITCH USP9X 0.623 17038327,19341794,26508657 Q9BY11 Q96J02 PACSIN1 ITCH 0.74 26613292 Q96J02 Q8N0X7 ITCH SPG20 0.731 19580544,19307600,19765186,20504295 Q96J02 O15350 ITCH TP73 0.939 15678106,17592138,17110958 Q96J02 Q96J02 ITCH ITCH 0.994 16446428,19997087,24790097,26949039,17719543,17996703,18718449,22496338,23146885,17038327,11724934,17592138 Q96J02 P36897 ITCH TGFBR1 0.21 15350225 Q96J02 Q92997 ITCH DVL3 0.21 22826439 Q96J02 P37088 ITCH SCNN1A 0.309 11244092 Q96J02 Q8WWW0 ITCH RASSF5 0.569 23538446 Q96J02 Q92783 ITCH STAM 0.671 22275353,26508657 Q96J02 Q96CS7 ITCH PLEKHB2 0.126 26186194 Q96J02 Q96G27 ITCH WBP1 0.126 26186194 Q96J02 A0AVT1 ITCH UBA6 0.126 26508657 Q96J02 O14828 ITCH SCAMP3 0.126 26508657 Q96J02 O14964 ITCH HGS 0.126 26508657 Q96J02 O15105 ITCH SMAD7 0.507 22773947,15946939 Q96J02 O75317 ITCH USP12 0.507 22778262,26811477 Q96J02 O75886 ITCH STAM2 0.523 22275353 Q96J02 P04062 ITCH GBA 0.376 23255161 Q96J02 P04637 ITCH TP53 0.507 18559494,21474069 Q96J02 P05412 ITCH JUN 0.569 19806201,19818398,16901904 Q96J02 P06241 ITCH FYN 0.569 16387660 Q96J02 P08195 ITCH SLC3A2 0.126 26508657 Q96J02 P12004 ITCH PCNA 0.126 26508657 Q96J02 P22314 ITCH UBA1 0.126 26508657 Q96J02 P28282 ITCH UL56 0.21 20682038 Q96J02 P39060 ITCH COL18A1 0.126 26508657 Q96J02 P42858 ITCH HTT 0.454 24865853 Q96J02 P45974 ITCH USP5 0.126 26508657 Q96J02 P46531 ITCH NOTCH1 0.21 23886940 Q96J02 P49407 ITCH ARRB1 0.376 18544533,17947233 Q96J02 P49427 ITCH CDC34 0.309 22496338 Q96J02 P51668 ITCH UBE2D1 0.309 25723849 Q96J02 P52292 ITCH KPNA2 0.126 26508657 Q96J02 P54252 ITCH ATXN3 0.376 24865853 Q96J02 P54259 ITCH ATN1 0.523 9647693 Q96J02 P55957 ITCH BID 0.21 20392206 Q96J02 P61073 ITCH CXCR4 0.82 19116316,24489825,22275353 Q96J02 P61077 ITCH UBE2D3 0.523 23644597,25723849 Q96J02 P61086 ITCH UBE2K 0.309 22496338 Q96J02 P62993 ITCH GRB2 0.081 26344197 Q96J02 P69720 ITCH VIF 0.569 15013426 Q96J02 P69721 ITCH VIF 0.569 15013426 Q96J02 P69722 ITCH VIF 0.569 15013426 Q96J02 P69723 ITCH VIF 0.569 15013426 Q96J02 P84022 ITCH SMAD3 0.309 15051726 Q96J02 Q03135 ITCH CAV1 0.21 22275353 Q96J02 Q13118 ITCH KLF10 0.376 18278048 Q96J02 Q13546 ITCH RIPK1 0.21 19131965 Q96J02 Q13635 ITCH PTCH1 0.376 25092867 Q96J02 Q14157 ITCH UBAP2L 0.183 16055720 Q96J02 Q14974 ITCH KPNB1 0.309 23538446 Q96J02 Q15366 ITCH PCBP2 0.376 19881509 Q96J02 Q15758 ITCH SLC1A5 0.126 26508657 Q96J02 Q15796 ITCH SMAD2 0.454 15350225 Q96J02 Q38SD2 ITCH LRRK1 0.183 24947832 Q96J02 Q5NHP0 ITCH GCVT 0.126 20711500 Q96J02 Q5S007 ITCH LRRK2 0.126 26508657 Q96J02 Q7Z434 ITCH MAVS 0.376 19881509 Q96J02 Q86VP1 ITCH TAX1BP1 0.376 18246070 Q96J02 Q8N2K1 ITCH UBE2J2 0.309 22496338 Q96J02 Q8N5I2 ITCH ARRDC1 0.801 26186194,23886940,23236378,21191027 Q96J02 Q8NEA6 ITCH GLIS3 0.569 26147758 Q96J02 Q8TAF3 ITCH WDR48 0.21 22778262 Q96J02 Q8TDB6 ITCH DTX3L 0.623 24790097 Q96J02 Q8WUM4 ITCH PDCD6IP 0.126 26508657 Q96J02 Q969T4 ITCH UBE2E3 0.309 22496338 Q96J02 Q969T9 ITCH WBP2 0.126 26508657 Q96J02 Q96B67 ITCH ARRDC3 0.702 23236378 Q96RF0 Q96J02 SNX18 ITCH 0.376 20491914 Q9BT67 Q96J02 NDFIP1 ITCH 0.569 26245901,25632008 Q9H0M0 Q96J02 WWP1 ITCH 0.126 26508657 Q9H469 Q96J02 FBXL15 ITCH 0.376 21572392 Q9HBA0 Q96J02 TRPV4 ITCH 0.21 20650893 Q9NWZ8 Q96J02 GEMIN8 ITCH 0.21 26908624 Q9UBN7 Q96J02 HDAC6 ITCH 0.126 26508657 Q9UHI6 Q96J02 DDX20 ITCH 0.21 26908624 Q96J02 P32121 ITCH ARRB2 0.569 17947233,18544533 Q96LR5 Q96J02 UBE2E2 ITCH 0.183 19549727 Q99732 Q96J02 LITAF ITCH 0.569 21326863,25963657 Q96J02 P45985 ITCH MAP2K4 0.623 19737936 Q96J02 P46937 ITCH YAP1 0.21 17110958 Q96J02 P17612 ITCH PRKACA 0.309 17437719 Q96J02 Q13618 ITCH CUL3 0.126 21145461 Q96J02 P81408 ITCH FAM189B 0.126 26186194 Q96J02 Q14155 ITCH ARHGEF7 0.794 26613292,17652093 Q96J02 F5HHZ3 ITCH UL42 0.21 26555021 Q96J02 Q14457 ITCH BECN1 0.309 21936852 Q96J02 P68400 ITCH CSNK2A1 0.309 17437719 Q96J02 P51168 ITCH SCNN1B 0.309 11244092 Q96J02 Q01860 ITCH POU5F1 0.702 23255053,19997087 Q96J02 Q15717 ITCH ELAVL1 0.126 19322201 Q96J02 Q15750 ITCH TAB1 0.569 25714464 Q96J02 Q15788 ITCH NCOA1 0.126 16051665 Q96J02 Q15884 ITCH FAM189A2 0.126 26186194 Q96J02 O00401 ITCH WASL 0.126 23414517 Q96J02 P68036 ITCH UBE2L3 0.993 25632008,26245901,22009753,20068034,15678106,26949039,17719543,17996703,15350225,18718449,17038327,25723849,17592138 Q96J02 Q16621 ITCH NFE2 0.74 18718448,11318614 Q96J02 Q16625 ITCH OCLN 0.21 19478092 Q96J02 Q16630 ITCH CPSF6 0.454 26508657,16055720 Q96J02 Q16637 ITCH SMN2 0.569 26908624 Q96J02 Q2TBE6 ITCH PI4K2A 0.702 23146885 Q96J02 P16815 ITCH UL42 0.21 26555021

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 UBA6 ITCH MI:0045 experimental interaction detection MI:0461 interaction database WWP2 ITCH MI:0362 inference MI:0461 interaction database WASL ITCH MI:0045 experimental interaction detection MI:0461 interaction database BIN1 ITCH MI:0045 experimental interaction detection MI:0461 interaction database ARID1A ITCH MI:0045 experimental interaction detection MI:0461 interaction database DVL1 ITCH MI:0045 experimental interaction detection MI:0461 interaction database DVL2 ITCH MI:0045 experimental interaction detection MI:0461 interaction database TNFRSF10B ITCH MI:0045 experimental interaction detection MI:0461 interaction database SCAMP3 ITCH MI:0045 experimental interaction detection MI:0461 interaction database IKBKB ITCH MI:0045 experimental interaction detection MI:0461 interaction database HGS ITCH MI:0045 experimental interaction detection MI:0461 interaction database SMAD7 ITCH MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database LDLRAD4 ITCH MI:0045 experimental interaction detection MI:0461 interaction database AXIN1 ITCH MI:0362 inference MI:0461 interaction database TP73 ITCH MI:0045 experimental interaction detection MI:0461 interaction database CFLAR ITCH MI:0045 experimental interaction detection MI:0461 interaction database MAP3K7 ITCH MI:0045 experimental interaction detection MI:0461 interaction database RIPK2 ITCH MI:0362 inference MI:1106 pathways database SMAD6 ITCH MI:0045 experimental interaction detection MI:0461 interaction database NUDT21 ITCH MI:0045 experimental interaction detection MI:0461 interaction database MGRN1 ITCH MI:0045 experimental interaction detection MI:0461 interaction database N4BP1 ITCH MI:0045 experimental interaction detection MI:0461 interaction database USP12 ITCH MI:0045 experimental interaction detection MI:0461 interaction database GRAP2 ITCH MI:0045 experimental interaction detection MI:0461 interaction database STAM2 ITCH MI:0045 experimental interaction detection MI:0461 interaction database URI1 ITCH MI:0045 experimental interaction detection MI:0461 interaction database DDX58 ITCH MI:0362 inference MI:1106 pathways database LATS1 ITCH MI:0045 experimental interaction detection MI:0461 interaction database EGFR ITCH MI:0045 experimental interaction detection MI:0461 interaction database GBA ITCH MI:0045 experimental interaction detection MI:0461 interaction database TP53 ITCH MI:0045 experimental interaction detection MI:0461 interaction database GNAI2 ITCH MI:0045 experimental interaction detection MI:0461 interaction database JUN ITCH MI:0045 experimental interaction detection MI:0461 interaction database FYN ITCH MI:0045 experimental interaction detection MI:0461 interaction database GSN ITCH MI:0045 experimental interaction detection MI:0461 interaction database ADRB2 ITCH MI:0045 experimental interaction detection MI:0461 interaction database GLI1 ITCH MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database SLC3A2 ITCH MI:0045 experimental interaction detection MI:0461 interaction database UBB ITCH MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database UBC ITCH MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database PABPC1 ITCH MI:0045 experimental interaction detection MI:0461 interaction database PCNA ITCH MI:0045 experimental interaction detection MI:0461 interaction database SRC ITCH MI:0045 experimental interaction detection MI:0461 interaction database HNRNPL ITCH MI:0045 experimental interaction detection MI:0461 interaction database JUNB ITCH MI:0362 inference MI:0461 interaction database PRKACA ITCH MI:0045 experimental interaction detection MI:0461 interaction database POLR2C ITCH MI:0045 experimental interaction detection MI:0461 interaction database POLR2E ITCH MI:0045 experimental interaction detection MI:0461 interaction database TNFAIP3 ITCH MI:0362 inference MI:0461 interaction database UBA1 ITCH MI:0045 experimental interaction detection MI:0461 interaction database CBL ITCH MI:0045 experimental interaction detection MI:0461 interaction database POLR2A ITCH MI:0045 experimental interaction detection MI:0461 interaction database GCA ITCH MI:0045 experimental interaction detection MI:0461 interaction database POLR2B ITCH MI:0045 experimental interaction detection MI:0461 interaction database SFN ITCH MI:0045 experimental interaction detection MI:0461 interaction database ARRB2 ITCH MI:0045 experimental interaction detection MI:0461 interaction database ARR3 ITCH MI:0045 experimental interaction detection MI:0461 interaction database TGFBR1 ITCH MI:0045 experimental interaction detection MI:0461 interaction database SCNN1A ITCH MI:0045 experimental interaction detection MI:0461 interaction database COL18A1 ITCH MI:0045 experimental interaction detection MI:0461 interaction database HTT ITCH MI:0045 experimental interaction detection MI:0461 interaction database USP5 ITCH MI:0045 experimental interaction detection MI:0461 interaction database MAPK8 ITCH MI:0045 experimental interaction detection MI:0461 interaction database MAPK9 ITCH MI:0362 inference MI:0461 interaction database MAP2K4 ITCH MI:0045 experimental interaction detection MI:0461 interaction database NOTCH1 ITCH MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database NEDD4 ITCH MI:0362 inference MI:0461 interaction database YAP1 ITCH MI:0045 experimental interaction detection MI:0461 interaction database ARRB1 ITCH MI:0045 experimental interaction detection MI:0461 interaction database CDC34 ITCH MI:0045 experimental interaction detection MI:0461 interaction database NUMB ITCH MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database SCNN1B ITCH MI:0045 experimental interaction detection MI:0461 interaction database UBE2D1 ITCH MI:0045 experimental interaction detection MI:0461 interaction database UBE2E1 ITCH MI:0045 experimental interaction detection MI:0461 interaction database KPNA2 ITCH MI:0045 experimental interaction detection MI:0461 interaction database NUDT6 ITCH MI:0362 inference MI:0461 interaction database MAPK10 ITCH MI:0362 inference MI:0461 interaction database ATXN3 ITCH MI:0045 experimental interaction detection MI:0461 interaction database ATN1 ITCH MI:0045 experimental interaction detection MI:0461 interaction database BID ITCH MI:0045 experimental interaction detection MI:0461 interaction database CXCR4 ITCH MI:0045 experimental interaction detection MI:0461 interaction database UBE2D3 ITCH MI:0045 experimental interaction detection MI:0461 interaction database UBE2K ITCH MI:0045 experimental interaction detection MI:0461 interaction database UBE2N ITCH MI:0362 inference MI:0461 interaction database UBE2G1 ITCH MI:0045 experimental interaction detection MI:0461 interaction database UBE2D2 ITCH MI:0045 experimental interaction detection MI:0461 interaction database RPS27A ITCH MI:0362 inference MI:0461,MI:1106 interaction database,pathways database UBA52 ITCH MI:0362 inference MI:0461,MI:1106 interaction database,pathways database UBE2L3 ITCH MI:0045 experimental interaction detection MI:0461 interaction database CSNK2A1 ITCH MI:0045 experimental interaction detection MI:0461 interaction database FAM189B ITCH MI:0045 experimental interaction detection MI:0461 interaction database SMAD3 ITCH MI:0045 experimental interaction detection MI:0461 interaction database MDM2 ITCH MI:0045 experimental interaction detection MI:0461 interaction database EWSR1 ITCH MI:0045 experimental interaction detection MI:0461 interaction database POU5F1 ITCH MI:0045 experimental interaction detection MI:0461 interaction database CAV1 ITCH MI:0045 experimental interaction detection MI:0461 interaction database NOTCH2 ITCH MI:0362 inference MI:0461 interaction database PTPN11 ITCH MI:0362 inference MI:0461 interaction database TRAF2 ITCH MI:0362 inference MI:0461 interaction database KLF10 ITCH MI:0045 experimental interaction detection MI:0461 interaction database BIRC3 ITCH MI:0362 inference MI:0461 interaction database BIRC2 ITCH MI:0362 inference MI:0461 interaction database RIPK1 ITCH MI:0045 experimental interaction detection MI:0461 interaction database LAPTM5 ITCH MI:0045 experimental interaction detection MI:0461 interaction database CUL3 ITCH MI:0045 experimental interaction detection MI:0461 interaction database TP53BP2 ITCH MI:0045 experimental interaction detection MI:0461 interaction database PTCH1 ITCH MI:0045 experimental interaction detection MI:0461 interaction database ARHGEF7 ITCH MI:0045 experimental interaction detection MI:0461 interaction database UBAP2L ITCH MI:0045 experimental interaction detection MI:0461 interaction database TRIM25 ITCH MI:0362 inference MI:1106 pathways database BECN1 ITCH MI:0045 experimental interaction detection MI:0461 interaction database NEDD9 ITCH MI:0045 experimental interaction detection MI:0461 interaction database KPNB1 ITCH MI:0045 experimental interaction detection MI:0461 interaction database LAPTM4A ITCH MI:0362 inference MI:0461 interaction database ERBB4 ITCH MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database RALBP1 ITCH MI:0362 inference MI:0461 interaction database PCBP2 ITCH MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database SF1 ITCH MI:0045 experimental interaction detection MI:0461 interaction database ELAVL1 ITCH MI:0045 experimental interaction detection MI:0461 interaction database TAB1 ITCH MI:0045 experimental interaction detection MI:0461 interaction database SLC1A5 ITCH MI:0045 experimental interaction detection MI:0461 interaction database NCOA1 ITCH MI:0045 experimental interaction detection MI:0461 interaction database SMAD2 ITCH MI:0045 experimental interaction detection MI:0461 interaction database ITSN1 ITCH MI:0045 experimental interaction detection MI:0461 interaction database FAM189A2 ITCH MI:0045 experimental interaction detection MI:0461 interaction database CDC37 ITCH MI:0362 inference MI:0461 interaction database NFE2 ITCH MI:0045 experimental interaction detection MI:0461 interaction database OCLN ITCH MI:0045 experimental interaction detection MI:0461 interaction database CPSF6 ITCH MI:0045 experimental interaction detection MI:0461 interaction database MLANA ITCH MI:0045 experimental interaction detection MI:0461 interaction database LRRK1 ITCH MI:0045 experimental interaction detection MI:0461 interaction database AMOT ITCH MI:0045 experimental interaction detection MI:0461 interaction database TMEM255A ITCH MI:0045 experimental interaction detection MI:0461 interaction database UBE2NL ITCH MI:0362 inference MI:0461 interaction database LRRK2 ITCH MI:0045 experimental interaction detection MI:0461 interaction database UBAP2 ITCH MI:0045 experimental interaction detection MI:0461 interaction database TMEM92 ITCH MI:0045 experimental interaction detection MI:0461 interaction database UBE2R2 ITCH MI:0362 inference MI:0461 interaction database MAVS ITCH MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database DTX2 ITCH MI:0362 inference MI:0461 interaction database LAPTM4B ITCH MI:0362 inference MI:0461 interaction database TAX1BP1 ITCH MI:0045 experimental interaction detection MI:0461 interaction database DTX1 ITCH MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database LDLRAD3 ITCH MI:0045 experimental interaction detection MI:0461 interaction database RNF135 ITCH MI:0362 inference MI:1106 pathways database RPAP2 ITCH MI:0045 experimental interaction detection MI:0461 interaction database SPG20 ITCH MI:0045 experimental interaction detection MI:0461 interaction database UBE2J2 ITCH MI:0045 experimental interaction detection MI:0461 interaction database ARRDC1 ITCH MI:0045 experimental interaction detection MI:0461 interaction database CPSF7 ITCH MI:0045 experimental interaction detection MI:0461 interaction database ARRDC4 ITCH MI:0045 experimental interaction detection MI:0461 interaction database GLIS3 ITCH MI:0045 experimental interaction detection MI:0461 interaction database WDR48 ITCH MI:0045 experimental interaction detection MI:0461 interaction database SMARCC2 ITCH MI:0045 experimental interaction detection MI:0461 interaction database DTX3L ITCH MI:0045 experimental interaction detection MI:0461 interaction database PDCD6IP ITCH MI:0045 experimental interaction detection MI:0461 interaction database TMEM171 ITCH MI:0045 experimental interaction detection MI:0461 interaction database RASSF5 ITCH MI:0045 experimental interaction detection MI:0461 interaction database STAM ITCH MI:0045 experimental interaction detection MI:0461 interaction database SMARCC1 ITCH MI:0045 experimental interaction detection MI:0461 interaction database USP13 ITCH MI:0045 experimental interaction detection MI:0461 interaction database DVL3 ITCH MI:0045 experimental interaction detection MI:0461 interaction database USP9X ITCH MI:0045 experimental interaction detection MI:0461 interaction database SMARCE1 ITCH MI:0045 experimental interaction detection MI:0461 interaction database UBE2E3 ITCH MI:0045 experimental interaction detection MI:0461 interaction database WBP2 ITCH MI:0045 experimental interaction detection MI:0461 interaction database ARRDC3 ITCH MI:0045 experimental interaction detection MI:0461 interaction database SGK3 ITCH MI:0045 experimental interaction detection MI:0461 interaction database PLEKHB2 ITCH MI:0045 experimental interaction detection MI:0461 interaction database DAZAP1 ITCH MI:0045 experimental interaction detection MI:0461 interaction database WBP1 ITCH MI:0045 experimental interaction detection MI:0461 interaction database SUCLG2 ITCH MI:0362 inference MI:0461 interaction database ITCH UBE2E2 MI:0045 experimental interaction detection MI:0461 interaction database ITCH NEDD4L MI:0362 inference MI:0461 interaction database ITCH SNX18 MI:0045 experimental interaction detection MI:0461 interaction database ITCH LITAF MI:0045 experimental interaction detection MI:0461 interaction database ITCH SH3GL2 MI:0045 experimental interaction detection MI:0461 interaction database ITCH NDFIP1 MI:0045 experimental interaction detection MI:0461 interaction database ITCH PI4K2A MI:0045 experimental interaction detection MI:0461 interaction database ITCH HNRNPUL1 MI:0045 experimental interaction detection MI:0461 interaction database ITCH KATNB1 MI:0362 inference MI:0461 interaction database ITCH PACSIN1 MI:0045 experimental interaction detection MI:0461 interaction database ITCH IFIH1 MI:0362 inference MI:1106 pathways database ITCH TOLLIP MI:0045 experimental interaction detection MI:0461 interaction database ITCH WWP1 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database ITCH TP63 MI:0045 experimental interaction detection MI:0461 interaction database ITCH TXNIP MI:0045 experimental interaction detection MI:0461 interaction database ITCH PTPN23 MI:0362 inference MI:0461 interaction database ITCH FBXL15 MI:0045 experimental interaction detection MI:0461 interaction database ITCH RPAP3 MI:0045 experimental interaction detection MI:0461 interaction database ITCH TRPV4 MI:0045 experimental interaction detection MI:0461 interaction database ITCH NOD2 MI:0362 inference MI:1106 pathways database ITCH CYLD MI:0045 experimental interaction detection MI:0461 interaction database ITCH NDFIP2 MI:0045 experimental interaction detection MI:0461 interaction database ITCH TMEM51 MI:0045 experimental interaction detection MI:0461 interaction database ITCH GGA3 MI:0045 experimental interaction detection MI:0461 interaction database ITCH WWOX MI:0045 experimental interaction detection MI:0461 interaction database ITCH HDAC6 MI:0045 experimental interaction detection MI:0461 interaction database ITCH CBLC MI:0045 experimental interaction detection MI:0461 interaction database ITCH NOTCH3 MI:0362 inference MI:0461 interaction database ITCH SUFU MI:0362 inference MI:1106 pathways database ITCH NOD1 MI:0362 inference MI:1106 pathways database ITCH DTX4 MI:0362 inference MI:0461 interaction database ITCH SH3GLB1 MI:0045 experimental interaction detection MI:0461 interaction database ITCH RNF11 MI:0045 experimental interaction detection MI:0461 interaction database ITCH TRAF6 MI:0045 experimental interaction detection MI:0461 interaction database ITCH SNX9 MI:0045 experimental interaction detection MI:0461 interaction database ITCH ARFGEF2 MI:0362 inference MI:0461 interaction database ITCH ARFGEF1 MI:0362 inference MI:0461 interaction database ITCH IKBKG MI:0362 inference MI:1106 pathways database ITCH NUMBL MI:0362 inference MI:0461 interaction database