PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus ODF2 CYLD 26638075 biogrid,intact exp P P P P P P P GP PMS1 CYLD 17148452 biogrid exp GP GP G G GP GP G G GP G GP GP GP GP G GP GP G P G GP G G GP GP GP GP GP XPO1 CYLD 26673895 biogrid exp GP GP G G GP GP G GP GP G GP G GP GP G GP GP GP P G GP GP GP GP GP GP GP GP OPTN CYLD 21408173 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP P G GP GP GP GP GP GP GP GP CEP192 CYLD 22895009,24613305,19615732 biogrid,intact exp GP P G GP GP G GP GP G GP GP GP GP G GP GP GP P G P GP GP GP GP GP GP GP UBE2S CYLD 20622874 biogrid exp G G G G G G G G GP G G G GP G G G G G G G G G G GP CNTROB CYLD 26638075 biogrid,intact exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP P G GP GP GP GP GP GP GP GP MGEA5 CYLD 19615732 biogrid,intact exp G GP G G G GP G G GP G GP G G GP G GP GP GP P G G GP G GP GP GP GP GP SPATA2L CYLD 19615732 biogrid,intact exp GP GP G G G GP G GP GP G GP GP GP GP G GP GP GP P G GP GP GP P GP GP GP GP CYLD ARHGEF12 23405219 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP P G GP GP GP GP GP GP GP GP CLIP3 CYLD 26017671,22297296 biogrid exp GP GP G P GP G GP GP G GP G GP G GP GP GP P G P G P P GP GP GP GP TRPA1 CYLD 16500080 innatedb,biogrid exp P P G GP P G P GP P P P P GP GP P P P P GP GP P GP P CEP350 CYLD 25134987 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP P G GP GP GP GP GP GP GP GP ANXA1 CYLD 23754495 intact exp GP G G G GP GP G G GP G GP G GP GP G G GP G G GP GP GP G G GP G G AURKB CYLD 20593489 biogrid exp P G GP P G GP P P P GP P P P GP P GP P YWHAB CYLD 24255178 biogrid,intact exp GP GP G G GP GP G G GP G GP GP GP GP G GP GP GP P G GP GP GP GP GP GP GP GP CD209 CYLD 24867235 biogrid exp G G G G GP G G G G G G G GP GP G G G G G G G G G G G G G FGL2 CYLD 26186194 biogrid exp G G G G GP GP G G GP G G G GP GP G G GP G G G G G G G GP G G CEP135 CYLD 26638075 biogrid,intact exp G G G G G G G G G G G G G G G G G G EIF2B5 CYLD bci exp GP GP G G GP GP G GP GP G G G G GP G GP GP GP P G GP GP GP G GP G GP GP PPP2R4 CYLD 20593489 biogrid exp GP GP G G GP GP G G GP G GP GP GP GP G GP GP G P G GP GP GP G GP G GP GP CYLD NINL 26638075 biogrid,intact exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G P G GP GP GP GP GP GP GP GP AKT1 CYLD 23300340 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP P G GP GP GP GP GP GP GP GP MED4 CYLD 25281560 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP P G GP GP GP GP GP GP GP GP CEP128 CYLD 26638075 biogrid,intact exp P P G GP P P P P P P P P P P P P P P P P GP PMS2 CYLD 17148452 biogrid exp P P P P P P P P P P P P P P P P P P P P MAPRE1 CYLD 24552808 biogrid exp GP GP G G G GP G G GP G GP G GP GP G GP GP GP P G GP GP GP G GP GP GP GP USP13 CYLD 19615732 biogrid,intact exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP P G GP GP GP GP GP G GP GP CYLD SPATA2 19615732 biogrid,intact exp GP GP G G GP GP G G GP G GP GP GP GP G GP GP G P G GP G G G GP GP GP GP CYLD SPHK1 26186194 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP P G GP GP GP GP GP GP GP GP UBC CYLD 19373254,17851586,20622874 biogrid,mint,intact exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP P G GP GP GP GP GP GP GP GP PPIP5K1 CYLD 18636086 biogrid exp GP GP G G GP GP G P GP G GP P P G GP GP GP P G P GP GP GP GP G GP GP CYLD CYLD 19615732 intact exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP P G GP GP GP GP GP GP GP GP CAMK2D CYLD 19615732 biogrid,intact exp G GP G G G GP G GP GP G GP G G GP G GP GP G P G G GP GP GP GP G GP GP BCL3 CYLD 19893491, 25402006, 21836163 biogrid exp, ortho, pred G G G GP G GP GP G G G GP G GP G GP G G G GP G GP G CYLD IKBKG 22990857,16627981,15341735,21988832,15870263,12917690,12917689,12917691, 25402006, 21836163 innatedb,hprd,biogrid,i2d,intact,bci exp, ortho, pred G G G G G G G G G G G G G G G G G G G G G G G G G G G TUBA1A CYLD 18222923,19893491, 25402006 biogrid,mint,intact exp, ortho, pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP P G GP GP GP GP GP GP GP GP SQSTM1 CYLD 19201866, 25402006, 23023127 biogrid exp, ortho, pred GP GP G G GP G G G GP G GP GP GP GP G GP G GP P G GP GP GP GP GP GP GP GP CYLD HDAC6 19893491,20593489, 25402006 biogrid,mint,intact exp, ortho, pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G P G GP GP GP GP GP GP GP GP RIPK1 CYLD 21408173,22848449,17981138, 25402006 biogrid exp, ortho, pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP P G GP GP GP GP GP GP GP GP ITCH CYLD 22057290, 23023127 biogrid,intact exp, ortho, pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP P G GP GP GP GP GP GP GP GP RNF31 CYLD 24461064, 23023127 innatedb exp, ortho, pred P P G G GP GP P P G GP GP GP P GP GP P P G GP P P GP GP GP P GP CYLD TRAF6 16230348,18382763,26056944,12917691,20622874, 25402006, 21836163 innatedb,hprd,biogrid,bci exp, ortho, pred GP GP G G GP G G GP GP G GP GP GP G G GP G GP G GP GP GP G GP GP GP GP MIB2 CYLD 25565632, 23023127 biogrid exp, pred P P G GP G GP P G GP P P P P GP GP P G GP GP GP GP GP P P P EGFR CYLD 12577067, 25402006 i2d exp, pred GP GP G GP G G GP G GP GP G G G GP GP G G GP GP G GP GP G GP GP MAVS CYLD 18467330,18636086, 25402006 innatedb,mint,intact exp, pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP P G GP GP GP GP GP GP GP GP PLK1 CYLD 17495026, 25402006 biogrid exp, pred P P G G GP P G GP GP P P P GP GP GP GP P G GP P GP GP GP P P GP CYLD TBK1 18636086, 25402006 innatedb,biogrid,mint,intact exp, pred GP GP G G GP GP G GP GP G GP G GP GP G GP GP GP P G GP GP GP GP GP GP GP GP CYLD LATS2 24255178, 23023127 biogrid exp, pred GP GP G G GP GP G G GP G GP GP GP GP G GP GP GP P G GP GP GP GP GP G GP GP CYLD MYO6 19615732, 25402006 biogrid,intact exp, pred GP GP G GP G G GP G GP GP GP G G GP GP G P G GP GP GP P GP G GP GP TRAIP CYLD 14676304, 21836163 hprd,biogrid,i2d,bci exp, pred P P P P P P P P P P P P P P P P P P P P P GP MAP3K7 CYLD 18332137, 25402006 biogrid exp, pred GP GP G G G GP G G GP G G GP GP G G G GP G P G GP GP G G G G GP GP DVL3 CYLD 20227366, 23023127 biogrid exp, pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP P G GP GP GP GP GP GP GP GP IKBKE CYLD 19481526,18636086,23453969, 25402006 innatedb,biogrid,mint,intact exp, pred G G G G G G G G G G G G G G G G G G G G G G G G G G G DDX58 CYLD 18467330,18636086, 25402006 innatedb,hprd,biogrid,mint,intact exp, pred GP GP G G GP GP G G GP G GP GP GP GP G GP GP GP P G GP GP GP GP GP GP GP GP TRAF3 CYLD 18467330, 25402006 innatedb exp, pred G GP G G GP GP G G G G GP GP GP GP G GP GP GP P G GP G GP G GP G GP GP TRAF7 CYLD 16230348, 21836163 hprd exp, pred GP GP G G G GP G GP GP G GP GP GP G G GP GP G G G G GP GP GP G GP GP TRAF2 CYLD 17851586,12917691,23405219, 25402006 innatedb,hprd,biogrid,i2d,bci exp, pred P P P P P P P P P P P P P P P P P P P GP GP P DVL1 CYLD 20227366, 23023127 biogrid exp, pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP P G GP GP GP GP GP GP GP GP FOS CYLD ortho GP GP G G GP GP G GP GP G GP GP GP G G GP GP GP P G GP GP GP GP GP GP GP GP JUN CYLD ortho GP GP G G G GP G G GP G GP G GP G G GP GP G G GP G GP G GP G GP G STAT3 CYLD ortho GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP P G GP GP GP GP GP GP GP GP CASP8 CYLD 25402006 ortho, pred GP GP G GP P GP GP GP GP GP GP G GP P GP P G GP GP GP P GP GP GP GP LCK CYLD 25402006 ortho, pred G G GP G G G G G G GP G G G G G GP G NTRK1 CYLD 25402006 ortho, pred P P P G P P P P P P P P P P P P P P P MYLIP CYLD 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G USP12 CYLD 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP P G GP GP GP GP GP GP GP GP SORBS3 CYLD 23023127 pred G G G G G GP G GP GP G GP GP G G G GP GP G P G GP GP GP GP GP G GP G CYLD USP15 23023127 pred G GP G G GP GP G G GP G GP GP GP GP G GP GP GP P G GP GP GP GP GP GP GP GP MCM7 CYLD 25402006 pred GP GP G G GP G G G GP G G G G GP G GP G GP G GP GP GP G GP G GP GP UBE2D3 CYLD 25402006 pred GP G G G GP GP G G GP G GP GP GP GP G G GP GP P G GP GP G GP G GP GP GP SIAH2 CYLD 23023127 pred G G G G G G G G G G G G G G G G G G G G G RPL23 CYLD 25402006 pred P P P P P P P P P P P P P P P P P P P P P P AXIN1 CYLD 23023127 pred GP GP G GP GP G P GP G GP GP GP GP G GP GP GP P G GP GP GP GP GP GP GP GP CYLD PKIG 23023127 pred GP GP G G G GP G GP GP G GP GP GP GP G GP GP GP P G GP GP GP GP GP GP GP GP TRIM21 CYLD 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP P G GP GP GP GP GP GP GP GP DPH3 CYLD 23023127 pred GP GP G G G GP G G GP G GP G GP GP G G GP G G GP G GP G G GP GP G CCL11 CYLD 23023127 pred G G G G G G G G G G G G G G G G G G LECT2 CYLD 23023127 pred P P P P G P P P GP CYLD FAF1 23023127 pred GP GP G G GP GP G GP GP G GP G GP GP G GP GP GP P G GP GP GP GP GP GP GP GP CXCL12 CYLD 23023127 pred GP GP G G GP GP G GP GP G GP G GP GP G GP GP G P G GP G G G GP GP G GP UBE2B CYLD 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G KATNB1 CYLD 23023127 pred GP GP G G G GP G GP GP G GP GP GP G G GP GP G P G GP GP GP GP GP G GP GP STK3 CYLD 23023127 pred GP GP G GP GP G GP GP G GP GP GP G G GP GP G P G GP GP G GP GP GP GP GP BTK CYLD 23023127 pred G G GP G G GP GP G G GP G CYLD TAB2 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G MYBPC3 CYLD 23023127 pred G G G G G GP G G G G G G G G G G G G G G G G TNFAIP3 CYLD 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP P G GP GP GP GP GP G GP GP CIDEA CYLD 23023127 pred G G G G G G G BIRC2 CYLD 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G P G GP G GP GP GP GP GP GP TPM3 CYLD 25402006 pred G P GP G GP G G GP G GP G G SMAD6 CYLD 23023127 pred G G G G G G G G G G G G G G G G G G G G G SLA2 CYLD 23023127 pred G G G G G G G G G G G G G G NCK1 CYLD 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP P G GP GP GP G GP GP GP GP IRF7 CYLD 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP P G GP GP GP GP GP GP GP GP USP7 CYLD 25402006, 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP P G GP GP GP GP GP GP GP GP PFKL CYLD 25402006 pred GP G G G GP GP G G GP G GP GP G G G GP GP G G GP G GP G GP G GP GP CYLD PACSIN3 23023127 pred GP GP GP G GP P P GP P G G GP GP GP P GP GP GP GP GP GP P TRIP6 CYLD 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP P G GP GP GP GP GP GP GP GP YOD1 CYLD 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP P G GP GP GP GP GP GP GP GP CADM1 CYLD 23023127 pred GP GP G GP G G GP G GP GP GP G G GP GP G P G GP GP GP G GP G GP GP NCF1 CYLD 23023127 pred P P P P HDAC11 CYLD 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G TGFBR1 CYLD 23023127 pred GP G G G GP GP G GP GP G GP GP GP G G GP GP G G G G 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GP P ATG5 CYLD 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP P G GP GP GP GP GP GP GP GP NLRP3 CYLD 23023127 pred P G GP P P P P P P P P BTC CYLD 23023127 pred G G G G G G CYLD G3BP2 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP P G GP GP GP GP GP GP GP GP CHFR CYLD 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G CHIA CYLD 23023127 pred P P G G P G GP P P GP GP P G GP GP GP G P P P G P P GP P TAX1BP3 CYLD 23023127 pred P P P P P P P P P P P P P P P P P FRZB CYLD 23023127 pred G GP G G GP GP G GP GP G GP G GP GP G GP GP GP P G GP G GP GP GP GP GP GP USP46 CYLD 23023127 pred GP GP G P GP G GP GP G GP P GP GP GP GP GP P G GP GP GP GP GP GP GP GP SPOP CYLD 25402006 pred G GP G G G GP G G GP G GP GP GP G G G GP G P G GP GP GP G G G GP GP CYLD KIF13B 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP P G GP G GP G GP G GP GP APBB1 CYLD 23023127 pred GP GP G G GP GP G GP GP G GP GP GP G G G GP G P G GP GP GP GP G GP GP GP LRP1 CYLD 23023127 pred G G G G G GP G G G G G GP GP G G G GP GP G GP G G G G G G GP TICAM1 CYLD 25402006 pred GP GP G P G GP GP GP GP GP GP G GP P GP P GP GP GP GP GP GP GP P NFKB1 CYLD 25402006 pred GP G G G GP G G G GP G G G GP GP G GP G G G GP GP GP G GP GP G GP TRIM25 CYLD 25402006 pred G GP G G GP GP G G GP G GP G GP GP G GP GP GP P G GP GP GP G GP GP GP GP ACTG1 CYLD 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP P G GP GP GP GP GP GP GP GP CYLD SENP1 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP P G GP GP GP GP GP GP GP GP CD27 CYLD 23023127 pred G G G GP G G G G G G GP G G G G G G G G G GP G GRB10 CYLD 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP P G GP GP GP GP GP GP GP GP LDLRAP1 CYLD 23023127 pred GP GP G G GP GP G GP GP G GP G GP GP G G GP GP P G GP G GP GP G GP GP GP UBASH3A CYLD 23023127 pred P P G P P P G NFKBIA CYLD 25402006, 23023127 pred G GP G G GP GP G GP GP G G G GP GP G GP GP G P G GP GP GP GP GP GP GP GP CYLD SNX9 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP P G GP GP GP GP GP GP GP GP NEDD4L CYLD 23023127 pred GP GP G GP G GP GP G GP G GP P G GP GP GP P G GP GP G G GP G GP G LRP6 CYLD 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP P G GP GP GP GP GP GP GP GP TSC1 CYLD 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP P G GP GP GP GP GP GP GP GP PXK CYLD 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP P G GP GP GP GP GP GP GP GP FYB CYLD 23023127 pred G G G GP G G G G G G G GP G G G G G G G G GP G RUNX3 CYLD 23023127 pred G G G G G G G G G GP G G G G G G G G SKI CYLD 23023127 pred GP GP G G GP GP G GP GP G GP G GP G G GP GP GP P G GP GP GP GP GP GP GP GP LGALS2 CYLD 25402006 pred P P GP P GP GP P P GP NAP1L1 CYLD 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP P G GP GP GP GP GP GP GP GP TRAF5 CYLD 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G P G GP GP GP GP GP GP GP GP STMN2 CYLD 23023127 pred G G G G 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CYLD 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP P G GP GP G P GP GP GP GP PFDN5 CYLD 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP P G GP GP GP GP GP GP GP GP LRP5 CYLD 23023127 pred GP GP P P G GP GP GP GP GP GP G GP P GP P G GP GP GP GP GP G GP P RELB CYLD 25402006 pred GP GP G G GP GP GP G GP GP GP GP G GP GP G G G G G G GP GP GP GP PTPRK CYLD 23023127 pred GP GP G G G GP G GP GP G GP GP GP G G GP GP GP P G GP G GP G GP G GP GP BMPR1A CYLD 23023127 pred GP GP G P GP G GP GP G GP GP GP GP G GP GP GP P G GP GP GP GP GP G GP GP PSMD12 CYLD 25402006 pred GP GP G G G GP G GP GP G GP GP GP GP G GP GP GP P G GP GP GP GP GP GP GP GP TRAF1 CYLD 25402006 pred G G G G GP GP G G GP G GP G G GP G G GP G G G G G G GP G G FGF9 CYLD 23023127 pred GP GP G P GP G G GP G GP P GP GP G GP GP G P G P GP GP GP GP P GP GP CDC37 CYLD 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP P G GP GP GP GP GP GP GP GP CYLD TUBA8 25402006 pred P P G GP P P GP P P P P P P P P P P P G P P P P AZI2 CYLD 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP P G GP GP GP GP GP GP GP GP UBE2V1 CYLD 25402006 pred IRAK1 CYLD 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP P G GP GP GP G GP GP GP GP FHL2 CYLD 25402006 pred GP GP G G GP GP G GP GP GP GP GP G G GP GP GP G GP GP G GP GP G GP GP GTF2H1 CYLD 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP P G GP GP GP GP GP GP GP GP HSP90AA1 CYLD 25402006 pred GP GP G G G GP G G GP G G G G G G G GP G G GP G G G G G G GP CDC25C CYLD 25402006 pred P P G GP P P GP P P P GP P P P P P P GP P P GP SLC25A32 CYLD 21836163 pred GP GP G G GP GP G GP GP G GP G G GP G GP GP GP P G GP G GP GP GP GP GP GP NFKB2 CYLD 25402006 pred GP GP G G GP GP G G GP G GP G GP GP G GP GP G P G GP G GP G GP GP GP GP SPTBN1 CYLD 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP P G GP GP GP GP GP GP GP GP SMURF1 CYLD 23023127 pred G GP G G GP GP G G GP G GP G GP G G G GP GP G GP G G G G GP G GP TGFB3 CYLD 23023127 pred GP GP G G GP GP G GP GP G GP GP GP G G GP GP GP P G G GP GP GP GP GP GP GP BORA CYLD 25402006 pred GP GP G G GP GP G GP GP GP GP P GP G GP GP GP P G GP GP GP GP GP GP GP GP SORBS1 CYLD 23023127 pred GP GP G G GP GP G GP GP G GP GP GP G G GP GP GP P G GP GP GP GP GP G GP GP RASA1 CYLD 23023127 pred GP G G G GP GP G G G G G G G G G G GP G G GP G G G G G GP G MAP3K14 CYLD 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G SMAD7 CYLD 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP P G GP GP GP GP GP GP GP P EGF CYLD 23023127 pred P P P P GP P GP P P P G P P P P GP GP GP GP P P P CXCL8 CYLD 23023127 pred G GP G G GP GP G GP G GP G G GP G G GP GP G G G G P G GP GP P CLTC CYLD 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G P G GP GP GP G GP GP GP GP CYLD HECTD1 23023127 pred GP GP G G G GP G GP GP G GP GP GP G G GP GP G P G GP GP GP GP GP G GP GP PACSIN1 CYLD 23023127 pred G GP G G P G P GP G PRKCQ CYLD 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G SMAD2 CYLD 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP P G GP GP GP GP GP GP GP GP COPS5 CYLD 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP P G GP GP GP GP GP GP GP GP SHH CYLD 23023127 pred GP GP G G GP GP G P GP G GP G GP GP GP GP P P G P GP P GP GP P GP GP IPO7 CYLD 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G P G GP GP GP G GP GP GP GP PIK3R1 CYLD 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP P G GP GP GP GP GP GP GP GP PKIA CYLD 23023127 pred P GP G GP G G P G P P P GP P GP G P G P GP GP G GP P P CD40 CYLD 25402006 pred G G G G G G G G G G G G G GP G G G G G G G G G G GP G G CYLD ABI3 23023127 pred G G G G GP GP G GP GP G GP G GP GP G GP GP G G G G GP GP GP G IRAK2 CYLD 25402006 pred GP GP G G GP GP G P P G GP GP GP GP GP GP G G G GP GP GP G GP P ROCK2 CYLD 23023127 pred GP GP G G G GP G GP GP G G G GP GP G GP GP GP P G GP GP GP GP GP GP GP GP PTPN2 CYLD 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP P G GP GP GP GP GP GP GP GP KALRN CYLD 23023127 pred P P G P GP G P P G P P P P P GP P P P P P P GP P P TUBB CYLD 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP P G GP GP GP GP GP GP GP GP MYL12A CYLD 25402006 pred P P P P P P P TAX1BP1 CYLD 25402006 pred GP GP G G GP GP G GP GP G GP G G GP G G GP GP G GP G GP GP G G GP GP GAS7 CYLD 23023127 pred G G G G GP GP G GP G G G G G G G G GP G G G G G G G GP G GP CYLD MALT1 25402006 pred G G GP G G G G G G GP G G G G G G G G G G G GP BCL10 CYLD 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP P G GP GP GP GP GP GP GP GP WDR5 CYLD 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G CYLD PSMD13 25402006 pred GP GP G G GP GP G GP GP G GP G GP GP G GP GP G P G GP GP GP GP GP GP GP GP NEB CYLD 23023127 pred G P G G G G P G G G G G GP G P G DNAJB6 CYLD 25402006 pred GP GP G G G GP G G G G G GP GP G G G GP G G G G G G G G G GP DVL2 CYLD 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP P G GP GP GP GP GP GP GP GP SFRP5 CYLD 23023127 pred P P P P G GP P P GP P G GP P P P P P G P P TP53 CYLD 25402006 pred G G G G G G G G G G G G G G G GP G G G GP G G G GP G G GP CYLD UBQLN1 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP P G GP GP GP GP GP GP GP GP DNAJA1 CYLD 25402006 pred GP GP G G GP GP G G GP G GP GP GP GP G GP GP GP P G GP GP GP G GP GP GP GP ARAP1 CYLD 23023127 pred GP GP G G GP GP G G GP G GP G GP GP G GP GP GP P G GP GP GP G GP G GP GP PTPRU CYLD 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP P G GP GP GP GP GP GP GP GP TNFRSF13B CYLD 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP P G GP GP GP GP GP GP GP GP SH3RF2 CYLD 23023127 pred P P P GP P P P P P P P P P P P GP HSPA1L CYLD 25402006 pred GP P G G G G G G G G P G G G G GP TRAF3IP2 CYLD 25402006 pred GP GP P P G P GP GP GP GP GP G GP P GP P G GP GP GP P GP GP GP P TNFRSF1B CYLD 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP P GP GP GP GP GP GP GP P TMEM173 CYLD 25402006 pred GP G G G GP GP G GP GP G G G GP GP G G GP G P G GP GP GP G G GP GP GP SKIL CYLD 23023127 pred GP GP G G GP GP G G GP G GP GP GP G G GP GP G G GP GP GP GP GP G GP GP CYLD ANLN 23023127 pred P G G GP GP GP G P P P GP G P GP P P GP GP BIN1 CYLD 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP P G GP GP GP GP GP GP GP GP TAB3 CYLD 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP P G GP GP GP GP GP GP GP GP GP1BA CYLD 21836163 pred G G G G GP GP G G G G G G G G G G GP G G G G G G G GP G G ZEB2 CYLD 23023127 pred G G G G GP GP G GP G G GP GP GP GP G G GP G G G G G G GP G G SLC25A5 CYLD 25402006 pred G GP G G GP GP G G G G GP GP G G G GP GP G P G G G GP G GP G GP GP TGFB1 CYLD 23023127 pred G G G G GP G G G G G G G G G G GP G G G GP G G GP GP GP G CYLD MBD2 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G P G GP GP GP GP GP GP GP GP PLEK CYLD 23023127 pred G G G G GP GP G G G G G G GP GP G G GP G G G G G G G G G G DCTN1 CYLD 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP P G GP GP GP GP GP GP GP GP CYLD RIMS2 23023127 pred P GP G G GP GP G P P G P P P GP P GP P P G GP GP P P P P P GP CYLD AXIN2 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP P G GP GP GP GP GP GP GP GP CYLD CCL26 23023127 pred NFKBIB CYLD 23023127 pred GP P G GP GP G GP P G GP GP GP GP G GP GP P P G GP GP GP GP GP GP GP GP BMP4 CYLD 23023127 pred G GP P P GP GP G P P G G GP P G P GP G P P GP GP P CYLD WWOX 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G P G GP GP GP GP GP GP GP GP CYLD USP3 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G SPRED3 CYLD 23023127 pred G G G G G G G G G G G G G G G G G G ATG12 CYLD 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP P G GP GP GP GP GP GP GP GP SMAD3 CYLD 23023127 pred GP GP G G G GP G G G G G G GP GP G G GP G P G GP G G G G G G G ARHGEF2 CYLD 23023127 pred GP GP G G GP GP G GP GP G GP G GP GP G GP GP GP P G GP GP GP GP GP GP GP GP RGS14 CYLD 23023127 pred GP GP G G G GP G GP GP G GP GP GP GP G GP GP G P G GP GP GP GP GP GP GP GP PEX13 CYLD 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP P G GP GP GP GP GP GP GP GP CYLD MAPK8IP1 23023127 pred P P G P GP G P P G P P P P P GP P G P P P P P P P GP PELI1 CYLD 25402006 pred GP GP G G GP GP G GP GP G GP GP GP G G GP GP GP P G GP GP GP GP GP GP GP GP TUBB4A CYLD 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP GP GP GP P G GP P GP GP GP GP GP GP RELA CYLD 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP P G GP GP GP GP GP GP GP GP PLG CYLD 23023127 pred P P G G P P P P ZCCHC11 CYLD 23023127 pred G GP G G GP GP G GP GP G GP G GP G G GP GP GP G GP G G GP GP G GP GP MAP4 CYLD 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP P G GP GP GP GP GP GP GP GP MID1 CYLD 23023127 pred G G G GP G GP GP G GP G G G G GP GP G P G GP G G GP GP G GP GP CYLD YBX2 23023127 pred G G G G G G G G G G G G G G G G G G G GP SKOR2 CYLD 23023127 pred P P P P P P P P P P P P P P P P P EGLN1 CYLD 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP P G GP GP GP GP GP GP GP GP HSP90AB1 CYLD 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP P G GP GP GP GP GP GP GP GP EPB41 CYLD 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G VAV2 CYLD 23023127 pred GP GP G G GP GP G G GP G GP GP GP G G GP GP GP P G GP GP GP GP GP GP GP BIRC3 CYLD 25402006 pred GP G GP G G GP P GP G GP G GP G P P G GP GP GP GP GP CFLAR CYLD 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP P G GP GP GP GP GP GP GP GP HSPA9 CYLD 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP P G GP GP GP GP GP GP GP GP HBP1 CYLD 23023127 pred G GP G G G GP G GP GP G GP G G G G G GP G G GP GP G GP G G GP GP CYLD FZD4 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G P G GP GP GP G GP G GP GP CYLD ITSN2 23023127 pred G G G G G GP G G GP G GP GP G G G GP GP G P G GP GP G G GP G GP GP DDX3X CYLD 25402006 pred G GP G G GP GP G G GP G G G GP GP G GP GP G P G GP GP GP G GP GP GP GP CALM1, CALM2, CALM3 CYLD 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP P G GP GP GP GP GP GP GP GP TRAF4 CYLD 25402006 pred G GP G GP G P GP G GP GP GP G G GP GP G P G GP G GP P GP G GP GP CYLD L3MBTL1 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G PRKCD CYLD 23023127 pred GP GP G G GP GP G GP GP GP P GP GP G GP GP GP P GP GP GP P GP GP GP GP CYLD RUVBL1 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP P G GP GP G GP G GP GP ACVR1C CYLD 23023127 pred G GP G G GP G GP GP G P G GP G G G G G GP P G G GP P PTPRF CYLD 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP P G GP GP GP GP GP GP GP HERPUD1 CYLD 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP P G GP GP GP GP GP GP GP GP CYLD CAMSAP3 23023127 pred P G GP GP G G GP GP G GP GP P P G GP G GP GP GP GP RSPO1 CYLD 23023127 pred P P P P P P P P G P P P P P P P P P P P TSC2 CYLD 23023127 pred G GP G G G GP G GP GP G GP GP GP G G GP GP GP P G GP G G G GP G GP GP SLIT2 CYLD 23023127 pred GP GP G G GP GP G GP GP G GP P GP GP G GP GP GP P G GP GP GP GP GP GP GP GP CYLD TNFRSF11A 25402006 pred GP P G GP P P GP P P GP G GP P P G P G G P GP GP P NEBL CYLD 23023127 pred GP GP G G G G G GP GP G GP GP GP GP G GP G G P G G G G G GP P GP G BRCA1 CYLD 23023127 pred P P G GP P P P P P P P GP P P P P P P P P P P GP RIPK2 CYLD 25402006 pred GP GP G G GP GP G GP GP G GP G GP GP G GP GP GP P G GP GP GP GP GP G G GP VAV1 CYLD 23023127 pred GP GP G GP GP G P P G P GP GP GP G GP GP G P G GP G GP P P GP GP GP CYLD BTG4 23023127 pred G G G BARX1 CYLD 23023127 pred G G G G GOPC CYLD 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP P G GP GP GP GP GP GP GP GP USP17L2 CYLD 23023127 pred P P P P P P P P P P P P P P P P P P P P INPP5D CYLD 23023127 pred G GP G G GP GP G GP G G GP G G GP G G GP GP G G G GP GP G GP G G PAFAH1B1 CYLD 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP P G GP GP GP GP GP GP GP GP USP8 CYLD 23023127 pred G GP G G GP GP G G GP G GP G GP G G GP GP G P G GP GP G GP GP G GP GP CYLD CD2AP 23023127 pred GP GP G GP P G G GP GP GP GP GP G GP GP G P G GP GP GP G GP GP GP GP TXN CYLD 23023127 pred GP GP G G G GP G GP GP G GP G GP GP G GP GP G P G GP G GP G GP GP GP GP PSMA4 CYLD 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP P G GP GP GP GP GP GP GP GP STAT5A CYLD 23023127 pred G GP G G GP G G G GP G GP GP GP GP G G G GP P G GP G G G G GP G G SUMO1 CYLD 25402006, 23023127 pred GP GP G G GP GP G GP GP G GP G GP GP G GP GP GP P G GP GP GP GP GP GP GP GP PRICKLE1 CYLD 23023127 pred G GP G G G GP G G G G GP G G G G G GP G P G GP GP G G G G GP GP HCLS1 CYLD 23023127 pred G G G G GP GP G G G G G G GP GP G G GP G G G G G G G GP G G CHD8 CYLD 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G MAP3K11 CYLD 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP P G GP GP GP GP GP GP GP GP STMN1 CYLD 23023127 pred GP GP G G GP GP G G GP G GP G GP GP G GP GP GP P G GP GP P G GP GP GP GP AKAP1 CYLD 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP P G GP GP GP GP GP GP GP GP CYLD USP20 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP P G GP GP GP GP GP GP GP GP PLCG2 CYLD 23023127 pred G GP G G GP GP G GP GP G GP G GP GP G GP GP GP G GP G G GP GP GP GP GP UBE2N CYLD 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G P G GP GP GP GP GP GP GP GP RNF125 CYLD 25402006 pred GP GP G G GP GP G G GP G GP G GP GP G GP GP GP P G GP GP GP GP GP GP GP P PPM1B CYLD 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP P G GP GP GP GP GP GP GP GP PPP1CC CYLD 25402006 pred GP GP G G G GP G GP GP G GP GP GP G G GP GP G P G GP GP GP GP GP GP GP GP PARP1 CYLD 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP P G GP GP GP GP GP GP GP GP DLC1 CYLD 23023127 pred G G G G G GP G G GP G GP G G G G GP GP G G G G G G GP G G GP KIF11 CYLD 25402006 pred P P G GP P P GP P P P P GP P P P P P P P P P GP GP HSPA5 CYLD 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP P G GP GP GP GP GP GP GP GP DVL1P1 CYLD 23023127 pred CYLD RERE 23023127 pred GP GP G G GP GP G G GP G GP GP GP GP G GP GP G P G GP GP GP G GP GP GP GP MACF1 CYLD 23023127 pred FLNA CYLD 23023127 pred G G G G GP GP G G GP G GP GP GP GP G G GP GP P G GP G G G G G GP GP SENP2 CYLD 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP P G GP GP GP GP GP GP GP GP CYLD USP16 23023127 pred GP GP G G GP GP G GP GP G GP G GP GP G GP GP G P G GP GP G GP GP GP GP GP CHUK CYLD 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP P G GP GP GP GP GP GP GP GP RIMBP2 CYLD 23023127 pred P P G P GP G P P G GP P P G GP GP P G P P P GP P P GP P CRYAB CYLD 23023127 pred GP G G G G GP G GP GP G GP G G G G G GP G G GP G G GP G G G G FOXP3 CYLD 23023127 pred G G G P P G G G P P TANK CYLD 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP P G GP GP GP GP GP GP GP GP FLII CYLD 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP P G GP GP GP GP GP GP GP GP EEF1A2 CYLD 25402006 pred G G GP G GP G G P P G G GP P G P GP G GP G GP G CYLD STARD13 25402006 pred GP GP G P GP G GP GP G GP GP G G G GP GP G P G GP GP GP GP GP G GP P TUBA3C, TUBA3D CYLD 25402006 pred P P P P P P P P P P P P P P DLG1 CYLD 23023127 pred GP GP G G GP GP G G GP G GP G GP GP G GP GP GP P G GP GP GP G GP GP GP GP IFIH1 CYLD 25402006 pred GP GP P P G GP GP GP GP GP G GP P G P G GP GP GP P GP GP GP P TRADD CYLD 25402006 pred GP GP G G GP GP G G GP G GP G GP GP G G GP G G GP GP GP G G GP GP GP STAM CYLD 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP P G GP GP GP G GP G GP GP CELSR2 CYLD 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP P G GP GP GP GP GP GP GP GP STXBP4 CYLD 23023127 pred P GP G GP P P P GP P P P G P P GP P G GP GP P P GP P P P BRMS1 CYLD 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP P G GP GP GP GP GP GP GP GP CYLD USP21 23023127 pred GP GP G G G GP G GP GP G GP GP GP G G GP GP G P G GP GP GP G GP G GP GP CYLD SPTBN5 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G SYTL4 CYLD 23023127 pred GP GP G G GP GP G G GP G GP GP GP GP G P GP GP P G GP GP GP GP G GP GP UHRF2 CYLD 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP P G GP GP GP GP GP GP GP GP TUBA4B CYLD 25402006 pred PYDC1 CYLD 23023127 pred G GTF2A2 CYLD 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G RBBP6 CYLD 23023127 pred GP G G G G GP G GP GP G GP GP GP G G GP GP G G GP G GP G GP GP GP GP TNFSF14 CYLD 23023127 pred GP P P P P P P GP GP G P P G P P P P P G P P BRCC3 CYLD 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G STK4 CYLD 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP P G GP GP GP GP GP GP GP GP MYL6 CYLD 25402006 pred G G G G GP GP G GP GP G G G GP G G G GP G G GP G G G G G G G PARK2 CYLD 23023127 pred P GP G P GP G GP GP G GP P P G P GP GP P G P GP GP GP P GP RBCK1 CYLD 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP P G GP GP GP GP GP GP GP GP RB1CC1 CYLD 25402006 pred G GP G G G GP G G GP G GP G GP G G GP GP GP P G GP GP GP G GP G GP GP DHX58 CYLD 25402006 pred P P P P P P P P P P P P P P PPP1R13B CYLD 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP P G GP GP GP GP GP GP GP GP RASSF9 CYLD 23023127 pred G P P P G GP P P P P P P P P P GP P P P P MAP3K1 CYLD 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP P G GP GP GP GP GP GP GP GP SYK CYLD 23023127 pred GP G G G GP GP G GP G GP G GP GP G GP GP P G G G G G GP GP GP GP TNF CYLD 25402006 pred G G G G G GP G G GP G G G GP G GP GP G P G G G G GP G GP G CCL24 CYLD 23023127 pred NCK2 CYLD 23023127 pred G GP G G GP GP G GP GP G GP GP GP GP G GP GP GP P G GP GP GP GP GP GP GP GP NKX2-5 CYLD 23023127 pred G G G G SIRT2 CYLD 25402006 pred G GP G G G GP G GP G G GP G GP G G GP GP G G G G G GP GP G G GP SPTBN2 CYLD 23023127 pred GP GP G GP G G GP GP P P GP P G GP GP P P P GP ARHGEF7 CYLD 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP P G GP GP G GP GP GP GP GP USP33 CYLD 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G P G GP GP GP GP GP G GP GP IRF3 CYLD 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP P G GP GP GP G GP GP GP GP TRIM37 CYLD 25402006 pred GP GP G G G GP G G GP G GP G GP G G GP GP G P G GP GP GP G GP G GP GP SP100 CYLD 23023127 pred GP GP G GP P G GP GP GP GP GP GP G GP P GP P G GP GP GP GP GP GP GP P CCNB1 CYLD 25402006 pred P G G GP G G G GP G P GP GP G G G GP G P GP P GP GP

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q9NQC7 Q9BWF2 - 14676304 - X 2 A0A024R8H5 Q9NQC7 - 12917691 - X 2 Q9Y6K9 Q9NQC7 - 12917691 - X 2 Q9NQC7 proximity-dependent biotin identification 24255178 colocalization C 74 Q9NQC7 anti tag coimmunoprecipitation 19615732 physical association C 10 Q9NQC7 anti bait coimmunoprecipitation 19893491 association C 3 Q9NQC7 anti bait coimmunoprecipitation 18977328 association C 3 Q9NQC7 anti tag coimmunoprecipitation 24255178 association C 142 Q14164 Q9NQC7 anti tag coimmunoprecipitation 18636086 physical association X 2 Q71U36 Q9NQC7 anti tag coimmunoprecipitation 19893491 physical association X 2 Q71U36 Q9NQC7 anti bait coimmunoprecipitation 19893491 physical association X 2 Q71U36 Q9NQC7 anti bait coimmunoprecipitation 19893491 physical association X 2 Q71U36 Q9NQC7 fluorescence technology 19893491 colocalization X 2 Q71U36 Q9NQC7 fluorescence technology 19893491 colocalization X 2 Q71U36 Q9NQC7 fluorescence technology 19893491 colocalization X 2 Q9NQC7 A0A024QZ26 anti tag coimmunoprecipitation 19893491 physical association X 2 Q9NQC7 A0A024QZ26 anti tag coimmunoprecipitation 19893491 physical association X 2 Q9NQC7 A0A024QZ26 anti bait coimmunoprecipitation 19893491 physical association X 2 Q9NQC7 Q7CIH9 two hybrid pooling approach 20711500 physical association X 2 Q9NQC7 anti bait coimmunoprecipitation 23754495 association C 20 Q9NQC7 anti bait coimmunoprecipitation 18977328 association C 3 Q9NQC7 anti tag coimmunoprecipitation 19615732 physical association C 7 Q9NQC7 anti tag coimmunoprecipitation 19615732 physical association C 18 Q9UHD2 Q9NQC7 anti tag coimmunoprecipitation 18636086 physical association X 2 Q9NQC7 O95786 anti tag coimmunoprecipitation 18636086 physical association X 2 Q9NQC7 O95786 anti bait coimmunoprecipitation 18636086 physical association X 2 Q96J02-2 Q9NQC7 pull down 22057290 physical association X 2 Q96J02-2 Q9NQC7 pull down 22057290 physical association X 2 Q96J02 Q9NQC7 anti tag coimmunoprecipitation 22057290 physical association X 2 Q96J02 Q9NQC7 anti tag coimmunoprecipitation 22057290 physical association X 2 Q96J02 Q9NQC7 anti tag coimmunoprecipitation 22057290 physical association X 2 Q7Z434 Q9NQC7 anti tag coimmunoprecipitation 18636086 physical association X 2 P0CG48 Q9NQC7 enzymatic study 19373254 deubiquitination reaction X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B CYLD TRAF6 MI:0415(enzymatic study)|MI:0018(two hybrid)|MI:0492(in vitro) 12917691,20622874 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0407(direct interaction)|- (biogrid)|(biogrid)|MI:0468(hprd) BIOGRID_165048|BIOGRID_133347|HPRD_25589 bait|bait|- prey|prey|- CYLD IKBKG MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0492(in vitro)|MI:0018(two hybrid)|MI:0004(affinity chromatography technology)|MI:0096(pull down)|MI:0004(affinity chromatography technology)|MI:0397(two hybrid array)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 12917689,12917690,12917691,15341735,16627981,21988832,22990857 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction)|-|MI:0407(direct interaction)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0407(direct interaction) (biogrid)|(biogrid)|MI:0468(hprd)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(intact)|(biogrid)|(biogrid)|(biogrid) BIOGRID_140060|BIOGRID_286218|HPRD_20267|BIOGRID_133339|BIOGRID_133349|BIOGRID_133350|BIOGRID_249636|UniProt_118761|BIOGRID_133343|BIOGRID_133341|BIOGRID_133345 bait|bait|-|prey|prey|prey|prey|unspecified role|bait|bait|bait prey|prey|-|bait|bait|bait|bait|unspecified role|prey|prey|prey CLIP3 CYLD MI:0018(two hybrid) 22297296 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_208350 bait prey MAVS CYLD MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0493(in vivo) 18636086 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|- (intact)|MI:0471(mint)|MI:0471(mint)|MI:0468(hprd) UniProt_97821|MINT_69143|MINT_39850|HPRD_40114 bait|bait|bait|- prey|prey|prey|- HDAC3 CYLD MI:0004(affinity chromatography technology) 22318606 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0796(suppressive genetic interaction defined by inequality) (biogrid) BIOGRID_192899 bait prey UBE2S CYLD MI:0415(enzymatic study) 20622874 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_165033 prey bait USP13 CYLD MI:0007(anti tag coimmunoprecipitation)|MI:0004(affinity chromatography technology) 19615732 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (intact)|(biogrid) UniProt_100660|BIOGRID_119428 bait|bait prey|prey MGEA5 CYLD MI:0007(anti tag coimmunoprecipitation)|MI:0004(affinity chromatography technology) 19615732 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (intact)|(biogrid) UniProt_100635|BIOGRID_120193 prey|prey bait|bait DVL1 CYLD MI:0004(affinity chromatography technology) 20227366 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_143504 prey bait AKT1 CYLD MI:0415(enzymatic study)|MI:0415(enzymatic study) 23300340 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_280462|BIOGRID_280464 prey|bait bait|prey BCL3 CYLD MI:0004(affinity chromatography technology) 19893491 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_127376 bait prey SPATA2L CYLD MI:0007(anti tag coimmunoprecipitation)|MI:0004(affinity chromatography technology) 19615732 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (intact)|(biogrid) UniProt_100635|BIOGRID_120800 prey|prey bait|bait PPIP5K1 CYLD MI:0004(affinity chromatography technology) 18636086 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_116642 bait prey DVL3 CYLD MI:0004(affinity chromatography technology) 20227366 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_143506 bait prey AURKB CYLD MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 20593489 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (biogrid)|(biogrid) BIOGRID_210362|BIOGRID_210363 prey|prey bait|bait ITCH CYLD MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0004(affinity chromatography technology)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation) 22057290 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid)|(intact)|(intact)|(intact)|(biogrid)|(intact)|(intact) BIOGRID_152853|BIOGRID_152852|UniProt_120639|UniProt_120638|UniProt_120635|BIOGRID_152851|UniProt_120637|UniProt_120636 bait|prey|null|null|bait|bait|prey|bait prey|bait|prey|prey|prey|prey|bait|prey DDX58 CYLD MI:0004(affinity chromatography technology)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0493(in vivo)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation) 18636086 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|-|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(intact)|(intact)|MI:0468(hprd)|MI:0471(mint)|MI:0471(mint)|MI:0471(mint)|MI:0471(mint) BIOGRID_116648|UniProt_97820|UniProt_97827|HPRD_33415|MINT_69141|MINT_69140|MINT_39847|MINT_39848 bait|bait|prey|-|prey|bait|bait|prey prey|prey|bait|-|bait|prey|prey|bait CAMK2D CYLD MI:0007(anti tag coimmunoprecipitation)|MI:0004(affinity chromatography technology) 19615732 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (intact)|(biogrid) UniProt_100635|BIOGRID_119375 prey|prey bait|bait TUBA1A CYLD MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation)|MI:0096(pull down)|MI:0006(anti bait coimmunoprecipitation)|MI:0096(pull down)|MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation)|MI:0096(pull down)|MI:0006(anti bait coimmunoprecipitation)|MI:0096(pull down)|MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation) 18222923,19893491 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0403(colocalization)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0403(colocalization)|MI:0915(physical association)|MI:0403(colocalization)|MI:0403(colocalization)|MI:0403(colocalization)|MI:0403(colocalization)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0403(colocalization)|MI:0915(physical association)|MI:0403(colocalization)|MI:0403(colocalization) MI:0471(mint)|MI:0471(mint)|MI:0471(mint)|(intact)|MI:0471(mint)|(intact)|MI:0471(mint)|MI:0471(mint)|(intact)|(biogrid)|MI:0471(mint)|(biogrid)|MI:0471(mint)|(intact)|(intact)|(intact)|MI:0471(mint)|(biogrid)|MI:0471(mint)|(biogrid)|MI:0471(mint)|MI:0471(mint) MINT_45598|MINT_45599|MINT_45597|UniProt_104167|MINT_76075|UniProt_104166|MINT_76088|MINT_76073|UniProt_104168|BIOGRID_210021|MINT_76078|BIOGRID_210020|MINT_76086|UniProt_104173|UniProt_104171|UniProt_104172|MINT_76072|BIOGRID_210018|MINT_45603|BIOGRID_210019|MINT_45600|MINT_45604 prey|prey|bait|prey|prey|bait|neutral component|prey|prey|bait|neutral component|bait|neutral component|neutral component|neutral component|neutral component|bait|prey|neutral component|prey|neutral component|neutral component bait|bait|prey|bait|bait|prey|neutral component|bait|bait|prey|neutral component|prey|neutral component|neutral component|neutral component|neutral component|prey|bait|neutral component|bait|neutral component|neutral component PMS2 CYLD MI:0004(affinity chromatography technology) 17148452 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_122077 bait prey MAP3K7 CYLD MI:0004(affinity chromatography technology) 18332137 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_117255 bait prey CYLD HDAC6 MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation)|MI:0004(affinity chromatography technology)|MI:0006(anti bait coimmunoprecipitation)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation) 19893491,20593489 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0914(association)|MI:0914(association)|MI:0914(association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) MI:0471(mint)|(intact)|MI:0471(mint)|(biogrid)|(intact)|(biogrid)|(biogrid)|MI:0471(mint)|MI:0471(mint)|MI:0471(mint)|MI:0471(mint)|(intact)|MI:0471(mint)|MI:0471(mint)|(intact) MINT_76090|UniProt_104175|MINT_45605|BIOGRID_127378|UniProt_104170|BIOGRID_127377|BIOGRID_210393|MINT_76091|MINT_76082|MINT_76083|MINT_45602|UniProt_104169|MINT_45601|MINT_45606|UniProt_104174 prey|prey|prey|bait|bait|bait|bait|bait|bait|bait|bait|bait|bait|bait|prey bait|bait|bait|prey|prey|prey|prey|bait|prey|prey|prey|prey|prey|bait|bait PMS1 CYLD MI:0004(affinity chromatography technology) 17148452 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_122123 bait prey SQSTM1 CYLD MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 19201866 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_148987|BIOGRID_148986 bait|prey prey|bait TRPA1 CYLD MI:0004(affinity chromatography technology) 16500080 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_124668 prey bait TRAIP CYLD MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0493(in vivo) 14676304 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0407(direct interaction)|- (biogrid)|(biogrid)|MI:0468(hprd) BIOGRID_132812|BIOGRID_132811|HPRD_20266 prey|prey|- bait|bait|- CYLD TBK1 MI:0007(anti tag coimmunoprecipitation)|MI:0004(affinity chromatography technology)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0493(in vivo) 18636086 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|- (intact)|(biogrid)|MI:0471(mint)|MI:0471(mint)|MI:0468(hprd) UniProt_97822|BIOGRID_116643|MINT_69144|MINT_39851|HPRD_40114 prey|prey|prey|prey|- bait|bait|bait|bait|- CYLD MYO6 MI:0007(anti tag coimmunoprecipitation)|MI:0004(affinity chromatography technology) 19615732 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (intact)|(biogrid) UniProt_100635|BIOGRID_119603 bait|bait prey|prey CYLD SPATA2 MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 19615732 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (intact)|(intact)|(biogrid)|(biogrid) UniProt_100635|UniProt_100720|BIOGRID_120102|BIOGRID_119429 bait|prey|bait|prey prey|bait|prey|bait TRAF7 CYLD MI:0493(in vivo) 16230348 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) - MI:0468(hprd) HPRD_25742 - - RIPK1 CYLD MI:0004(affinity chromatography technology)|MI:0018(two hybrid)|MI:0004(affinity chromatography technology) 17981138,21408173,22848449 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid) BIOGRID_117756|BIOGRID_143497|BIOGRID_207970 bait|prey|prey prey|bait|bait OPTN CYLD MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 21408173 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid) BIOGRID_143491|BIOGRID_143493|BIOGRID_143492 bait|bait|prey prey|prey|bait TRAF2 CYLD MI:0492(in vitro)|MI:0018(two hybrid)|MI:0004(affinity chromatography technology)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 12917691,23405219 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) -|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0407(direct interaction) MI:0468(hprd)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid) HPRD_20268|BIOGRID_133340|BIOGRID_250830|BIOGRID_133344|BIOGRID_133342|BIOGRID_133346 -|bait|bait|prey|prey|prey -|prey|prey|bait|bait|bait UBC CYLD MI:0415(enzymatic study)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0114(x-ray crystallography)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0114(x-ray crystallography)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0114(x-ray crystallography)|MI:0004(affinity chromatography technology) 10,17851586,18977328,19373254,20622874,21139048,22505724,23000965 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0204(deubiquitination reaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0204(deubiquitination reaction)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0204(deubiquitination reaction)|MI:0407(direct interaction) (biogrid)|(biogrid)|(biogrid)|MI:0471(mint)|(biogrid)|(biogrid)|(intact)|(biogrid)|(biogrid)|MI:0471(mint)|(biogrid) BIOGRID_165019|BIOGRID_270139|BIOGRID_161329|MINT_74135|BIOGRID_172249|BIOGRID_261546|UniProt_100031|BIOGRID_161331|BIOGRID_223547|MINT_43923|BIOGRID_190910 prey|bait|bait|neutral component|bait|prey|neutral component|prey|bait|neutral component|prey bait|prey|prey|neutral component|prey|bait|neutral component|bait|prey|neutral component|bait CEP192 CYLD MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0007(anti tag coimmunoprecipitation) 19615732,22895009 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid)|(intact) BIOGRID_260191|BIOGRID_260192|BIOGRID_120512|UniProt_100635 bait|bait|prey|prey prey|prey|bait|bait IKBKE CYLD MI:0007(anti tag coimmunoprecipitation)|MI:0004(affinity chromatography technology)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0004(affinity chromatography technology)|MI:0493(in vivo) 18636086,23453969 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|- (intact)|(biogrid)|MI:0471(mint)|MI:0471(mint)|(biogrid)|MI:0468(hprd) UniProt_97823|BIOGRID_116644|MINT_69145|MINT_39852|BIOGRID_258063|HPRD_40114 bait|bait|bait|bait|prey|- prey|prey|prey|prey|bait|- PPP2R4 CYLD MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 20593489 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_210392|BIOGRID_210391 bait|bait prey|prey CYLD ARHGEF12 MI:0004(affinity chromatography technology) 23405219 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_250831 bait prey PLK1 CYLD MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 17495026 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_119325|BIOGRID_119326 prey|bait bait|prey YWHAB CYLD MI:0004(affinity chromatography technology)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation) 24255178 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0914(association)|MI:0914(association) (biogrid)|(intact)|(intact) BIOGRID_293468|UniProt_176935|UniProt_131089 bait|bait|bait prey|prey|prey CYLD LATS2 MI:0004(affinity chromatography technology) 24255178 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_292944 prey bait

PPI - HINT Gene A Gene B PMID Method Quality MGEA5 CYLD 19615732,19615732 0004,0007 HT DDX58 CYLD 18636086,18636086,18636086,18467330 0004,0007,0006,0007 LC YWHAB CYLD 24255178 0007 HT TRAF2 CYLD 23405219,12917691,12917691,17851586,12917691,12917691 0004,0415,0004,0007,0019,0018 LC RIPK1 CYLD 17981138,22848449,21408173 0004,0004,0004 LC CAMK2D CYLD 19615732,19615732 0004,0007 HT IKBKE CYLD 23453969,18636086,19481526,19481526,18636086 0004,0007,0007,0423,0004 LC FGL2 CYLD 26186194 0004 HT ODF2 CYLD 26638075,26638075 1314,1313 HT CEP135 CYLD 26638075,26638075 1314,1313 HT CEP128 CYLD 26638075,26638075 1314,1313 HT TUBA1A CYLD 18222923,19893491,19893491,19893491,18222923 0004,0051,0007,0006,0096 LC MAVS CYLD 18467330,18636086 0007,0007 LC SPATA2L CYLD 19615732,19615732 0004,0007 HT CNTROB CYLD 26638075,26638075 1314,1313 HT CEP192 CYLD 19615732,19615732 0004,0007 HT USP13 CYLD 19615732,19615732 0004,0007 HT OPTN CYLD 25923723,25923723,21408173,21408173,21408173 0428,0004,0096,0018,0004 LC CLIP3 CYLD 22297296,26017671 0004,0004 LC KIAA1569 CYLD 22895009,19615732,24613305 0004,0004,1313 LC,HT CYLD LATS2 24255178 1313 HT CYLD SPHK1 26186194 0004 HT CYLD HDAC6 19893491,20593489,19893491,19893491,19893491 0007,0004,0006,0004,0096 LC CYLD TBK1 18636086,25923723,25923723,18636086 0007,0428,0004,0004 LC CYLD MYO6 19615732,19615732 0004,0007 HT CYLD SPATA2 19615732,19615732 0004,0007 HT CYLD NINL 26638075,26638075 1314,1313 HT CYLD TRAF6 26056944,18382763 0004,0007 LC CYLD IKBKG 12917689,15341735,12917689,12917691,12917689,16627981,22990857,12917691,12917690,15870263,12917691,12917690,15870263,26802121,12917691 0018,0007,0007,0019,0096,0004,0004,0415,0007,0423,0004,0004,0007,0004,0018 LC CYLD HEL-S-1 24255178 0004 HT MGEA5 CYLD 19615732,19615732 0004,0007 HT YWHAB CYLD 24255178 0007 HT CAMK2D CYLD 19615732,19615732 0004,0007 HT FGL2 CYLD 26186194 0004 HT ODF2 CYLD 26638075,26638075 1314,1313 HT CEP135 CYLD 26638075,26638075 1314,1313 HT CEP128 CYLD 26638075,26638075 1314,1313 HT SPATA2L CYLD 19615732,19615732 0004,0007 HT CNTROB CYLD 26638075,26638075 1314,1313 HT CEP192 CYLD 19615732,19615732 0004,0007 HT USP13 CYLD 19615732,19615732 0004,0007 HT KIAA1569 CYLD 19615732 0004 HT CYLD LATS2 24255178 1313 HT CYLD SPHK1 26186194 0004 HT CYLD MYO6 19615732,19615732 0004,0007 HT CYLD SPATA2 19615732,19615732 0004,0007 HT CYLD NINL 26638075,26638075 1314,1313 HT CYLD HEL-S-1 24255178 0004 HT DDX58 CYLD 18636086,18636086,18636086,18467330 0004,0007,0006,0007 LC TRAF2 CYLD 23405219,12917691,12917691,17851586,12917691,12917691 0004,0415,0004,0007,0019,0018 LC RIPK1 CYLD 17981138,22848449,21408173 0004,0004,0004 LC IKBKE CYLD 23453969,18636086,19481526,19481526,18636086 0004,0007,0007,0423,0004 LC TUBA1A CYLD 18222923,19893491,19893491,19893491,18222923 0004,0051,0007,0006,0096 LC MAVS CYLD 18467330,18636086 0007,0007 LC OPTN CYLD 25923723,25923723,21408173,21408173,21408173 0428,0004,0096,0018,0004 LC CLIP3 CYLD 22297296,26017671 0004,0004 LC KIAA1569 CYLD 22895009,24613305 0004,1313 LC CYLD HDAC6 19893491,20593489,19893491,19893491,19893491 0007,0004,0006,0004,0096 LC CYLD TBK1 18636086,25923723,25923723,18636086 0007,0428,0004,0004 LC CYLD TRAF6 26056944,18382763 0004,0007 LC CYLD IKBKG 12917689,15341735,12917689,12917691,12917689,16627981,22990857,12917691,12917690,15870263,12917691,12917690,15870263,26802121,12917691 0018,0007,0007,0019,0096,0004,0004,0415,0007,0423,0004,0004,0007,0004,0018 LC UBC CYLD 17851586,17851586,19373254,20622874 0415,0004,0415,0415 LC AKT1 CYLD 23300340,23300340 0415,0004 LC TRAF2 CYLD 12917691,12917691,12917691,12917691 0415,0004,0019,0018 LC IKBKE CYLD 19481526,19481526 0007,0423 LC MAPRE1 CYLD 24552808,24552808,24552808 0096,0004,0018 LC UBE2S CYLD 20622874 0415 LC TUBA1A CYLD 19893491,19893491,19893491 0051,0007,0006 LC MIB2 CYLD 25565632,25565632 0415,0004 LC OPTN CYLD 21408173,21408173,21408173 0096,0018,0004 LC TRAIP CYLD 14676304,14676304,14676304 0047,0018,0019 LC CYLD CYLD 18313383 0114 LC CYLD TRAF6 20622874,12917691 0415,0415 LC CYLD IKBKG 12917689,12917689,12917691,12917689,12917691,15870263,12917691,21988832,15870263,12917691 0018,0007,0019,0096,0415,0423,0004,0018,0007,0018 LC,HT

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q9NQC7 Q5BJF6 CYLD ODF2 0.126 26638075 Q9NQC7 O14980 CYLD XPO1 0.126 26673895 Q9NQC7 Q5VT06 CYLD CEP350 0.376 25134987 Q9NQC7 O43318 CYLD MAP3K7 0.21 18332137 Q9NQC7 Q8N137 CYLD CNTROB 0.126 26638075 Q9NQC7 Q9HC29 CYLD NOD2 0.21 26670046 Q9NQC7 Q9NNX6 CYLD CD209 0.21 24867235 Q9NQC7 Q9NPJ6 CYLD MED4 0.126 25281560 Q9NQC7 O14640 CYLD DVL1 0.21 20227366 Q9NQC7 O75762 CYLD TRPA1 0.21 16500080 Q9NQC7 Q15691 CYLD MAPRE1 0.702 24552808 Q9NQC7 Q16763 CYLD UBE2S 0.309 20622874 Q9NQC7 Q7CIH9 CYLD NUDG 0.126 20711500 Q9NQC7 Q96CV9 CYLD OPTN 0.74 21408173,25923723 Q9NQC7 Q96DZ5 CYLD CLIP3 0.507 22297296,26017671 Q9NQC7 Q96J02 CYLD ITCH 0.569 22057290 Q9NQC7 Q9H0F6 CYLD SHARPIN 0.376 26670046 Q9NZN5 Q9NQC7 ARHGEF12 CYLD 0.21 23405219 Q9UQM7 Q9NQC7 CAMK2A CYLD 0.21 24614225 Q9NRM7 Q9NQC7 LATS2 CYLD 0.126 24255178 Q9NYA1 Q9NQC7 SPHK1 CYLD 0.126 26186194 Q9NQC7 Q8TEP8 CYLD CEP192 0.396 19615732,22895009 Q9Y2I6 Q9NQC7 NINL CYLD 0.126 26638075 Q9Y4K3 Q9NQC7 TRAF6 CYLD 0.702 20622874,26056944,12917691 Q9NQC7 Q6ZU80 CYLD CEP128 0.126 26638075 Q9NQC7 P0CG48 CYLD UBC 0.681 20622874,19373254,17851586 Q9NQC7 Q7TSJ6 CYLD LATS2 0.081 24255178 Q9NQC7 Q7Z434 CYLD MAVS 0.21 18636086 Q9NQC7 Q6P5F9 CYLD XPO1 0.126 26673895 Q9NQC7 Q6PFW1 CYLD PPIP5K1 0.21 18636086 Q9NQC7 P01375 CYLD TNF 0.21 26670046 Q9NQC7 P04083 CYLD ANXA1 0.21 23754495 Q9NQC7 O60502 CYLD MGEA5 0.236 19615732 Q9NQC7 O95786 CYLD DDX58 0.692 18636086 Q9NQC7 Q9BWF2 CYLD TRAIP 0.523 14676304 Q9NQC7 Q13557 CYLD CAMK2D 0.236 19615732 Q9NQC7 Q14164 CYLD IKBKE 0.61 23453969,18636086 Q9NQC7 Q96GD4 CYLD AURKB 0.454 20593489 Q9NQC7 Q8IUW3 CYLD SPATA2L 0.236 19615732 Q9UM54 Q9NQC7 MYO6 CYLD 0.236 19615732 Q9UM82 Q9NQC7 SPATA2 CYLD 0.416 19615732 Q9UBN7 Q9NQC7 HDAC6 CYLD 0.787 19893491,20593489 Q9NQC7 P03126 CYLD E6 0.376 18977328 Q9NQC7 Q92995 CYLD USP13 0.236 19615732 Q9NQC7 P06463 CYLD E6 0.376 18977328 Q9NQC7 Q15257 CYLD PPP2R4 0.454 20593489 Q9NQC7 Q12933 CYLD TRAF2 0.794 23405219,12917691 Q9NQC7 Q66GS9 CYLD CEP135 0.236 26638075 Q9NQC7 P31946 CYLD YWHAB 0.236 24255178 Q9NQC7 Q71U36 CYLD TUBA1A 0.858 19893491,18222923 Q9UHD2 Q9NQC7 TBK1 CYLD 0.569 18636086,25923723 Q9Y6K9 Q9NQC7 IKBKG CYLD 0.963 12917690,22990857,16627981,21988832,26802121,12917689,12917691 Q9NQC7 Q92997 CYLD DVL3 0.21 20227366 Q9NQC7 Q96AX9 CYLD MIB2 0.454 25565632 Q9NQC7 Q96EP0 CYLD RNF31 0.376 26670046 Q9NQC7 P31749 CYLD AKT1 0.454 23300340 Q9NQC7 Q99836 CYLD MYD88 0.21 26719415 Q9UL18 Q9NQC7 AGO1 CYLD 0.21 25595906 Q9NQC7 Q13546 CYLD RIPK1 0.507 21408173,17981138,22848449 Q9NQC7 Q14314 CYLD FGL2 0.126 26186194 Q9NQC7 Q13501 CYLD SQSTM1 0.376 19201866 Q9NQC7 P19438 CYLD TNFRSF1A 0.21 24098568 Q9NQC7 P20749 CYLD BCL3 0.21 19893491 Q9NQC7 P53350 CYLD PLK1 0.376 17495026 Q9NQC7 P54277 CYLD PMS1 0.126 17148452 Q9NQC7 P54278 CYLD PMS2 0.126 17148452

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 TRAF5 CYLD MI:0362 inference MI:0461 interaction database DVL1 CYLD MI:0045 experimental interaction detection MI:0461 interaction database IKBKB CYLD MI:0362 inference MI:0461,MI:1106 interaction database,pathways database XPO1 CYLD MI:0045 experimental interaction detection MI:0461 interaction database CHUK CYLD MI:0362 inference MI:1106 pathways database MAP3K7 CYLD MI:0045 experimental interaction detection MI:0461 interaction database RIPK2 CYLD MI:0362 inference MI:0461,MI:1106 interaction database,pathways database MGEA5 CYLD MI:0045 experimental interaction detection MI:0461 interaction database TRPA1 CYLD MI:0045 experimental interaction detection MI:0461 interaction database DDX58 CYLD MI:0045 experimental interaction detection MI:0461 interaction database FOS CYLD MI:0362 inference MI:0461 interaction database TNF CYLD MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database ANXA1 CYLD MI:0045 experimental interaction detection MI:0461 interaction database NTRK1 CYLD MI:0362 inference MI:0461 interaction database JUN CYLD MI:0362 inference MI:0461 interaction database LCK CYLD MI:0362 inference MI:0461 interaction database UBC CYLD MI:0045 experimental interaction detection MI:0461 interaction database TNFRSF1A CYLD MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database BCL3 CYLD MI:0045 experimental interaction detection MI:0461 interaction database TNFAIP3 CYLD MI:0362 inference MI:0461 interaction database MAP4 CYLD MI:0362 inference MI:0461 interaction database AKT1 CYLD MI:0045 experimental interaction detection MI:0461 interaction database YWHAB CYLD MI:0045 experimental interaction detection MI:0461 interaction database STAT3 CYLD MI:0362 inference MI:0461 interaction database HNF4A CYLD MI:0045 experimental interaction detection MI:0461 interaction database PLK1 CYLD MI:0045 experimental interaction detection MI:0461 interaction database PMS1 CYLD MI:0045 experimental interaction detection MI:0461 interaction database PMS2 CYLD MI:0045 experimental interaction detection MI:0461 interaction database TRAF2 CYLD MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database BIRC3 CYLD MI:0362 inference MI:1106 pathways database BIRC2 CYLD MI:0362 inference MI:1106 pathways database SQSTM1 CYLD MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database RIPK1 CYLD MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database CAMK2D CYLD MI:0045 experimental interaction detection MI:0461 interaction database IKBKE CYLD MI:0045 experimental interaction detection MI:0461 interaction database FGL2 CYLD MI:0045 experimental interaction detection MI:0461 interaction database CASP8 CYLD MI:0362 inference MI:0461 interaction database PPP2R4 CYLD MI:0045 experimental interaction detection MI:0461 interaction database TRADD CYLD MI:0362 inference MI:0461,MI:1106 interaction database,pathways database MAPRE1 CYLD MI:0045 experimental interaction detection MI:0461 interaction database UBE2S CYLD MI:0045 experimental interaction detection MI:0461 interaction database ODF2 CYLD MI:0045 experimental interaction detection MI:0461 interaction database CEP350 CYLD MI:0045 experimental interaction detection MI:0461 interaction database CEP135 CYLD MI:0045 experimental interaction detection MI:0461 interaction database PPIP5K1 CYLD MI:0045 experimental interaction detection MI:0461 interaction database CEP128 CYLD MI:0045 experimental interaction detection MI:0461 interaction database TUBA1A CYLD MI:0045 experimental interaction detection MI:0461 interaction database MAVS CYLD MI:0045 experimental interaction detection MI:0461 interaction database SPATA2L CYLD MI:0045 experimental interaction detection MI:0461 interaction database CNTROB CYLD MI:0045 experimental interaction detection MI:0461 interaction database CEP192 CYLD MI:0045 experimental interaction detection MI:0461 interaction database USP13 CYLD MI:0045 experimental interaction detection MI:0461 interaction database DVL3 CYLD MI:0045 experimental interaction detection MI:0461 interaction database MIB2 CYLD MI:0045 experimental interaction detection MI:0461 interaction database OPTN CYLD MI:0045 experimental interaction detection MI:0461 interaction database CLIP3 CYLD MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database RNF31 CYLD MI:0045 experimental interaction detection MI:0461 interaction database AURKB CYLD MI:0045 experimental interaction detection MI:0461 interaction database ITCH CYLD MI:0045 experimental interaction detection MI:0461 interaction database MYD88 CYLD MI:0045 experimental interaction detection MI:0461 interaction database TRAIP CYLD MI:0045 experimental interaction detection MI:0461 interaction database SHARPIN CYLD MI:0045 experimental interaction detection MI:0461 interaction database NOD2 CYLD MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database CD209 CYLD MI:0045 experimental interaction detection MI:0461 interaction database MED4 CYLD MI:0045 experimental interaction detection MI:0461 interaction database CYLD LATS2 MI:0045 experimental interaction detection MI:0461 interaction database CYLD SPHK1 MI:0045 experimental interaction detection MI:0461 interaction database CYLD ARHGEF12 MI:0045 experimental interaction detection MI:0461 interaction database CYLD HDAC6 MI:0045 experimental interaction detection MI:0461 interaction database CYLD TBK1 MI:0045 experimental interaction detection MI:0461 interaction database CYLD AGO1 MI:0045 experimental interaction detection MI:0461 interaction database CYLD MYO6 MI:0045 experimental interaction detection MI:0461 interaction database CYLD SPATA2 MI:0045 experimental interaction detection MI:0461 interaction database CYLD CAMK2A MI:0045 experimental interaction detection MI:0461 interaction database CYLD NOD1 MI:0362 inference MI:1106 pathways database CYLD NINL MI:0045 experimental interaction detection MI:0461 interaction database CYLD TRAF6 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database CYLD IKBKG MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database