Disease associated variation - GWASdb Chr Pos SNP ID(dbSNP 142) Ref Alt Ori SNP ID P-value Drug Name Drug Anno GWAS Trait HPO ID DO ID AA Type Trait or Drug 2 234396566 rs10929178 G C rs10929178 5.29E-04 CITRULLINE PEPTIDES|HLA-DRB1 CHAINS|HLA ANTIGENS|AUTOANTIBODIES|HLA-B ANTIGENS Rheumatoid arthritis (ACPA-negative) HPOID:0001370 DOID:7148 G intron GWASdb_drug 2 234386803 rs745155 T G rs745155 7.61E-05 Partial epilepsies HPOID:0001250 DOID:1826 G intron GWASdb_trait 2 234388689 rs2971865 G A rs2971865 8.39E-04 Multiple complex diseases HPOID:0000118 NA G intron GWASdb_trait 2 234390469 rs3796092 C A rs3796092 1.40E-19 Bilirubin levels HPOID:0002904 DOID:2741 G intron GWASdb_trait 2 234390602 rs3796090 T C rs3796090 1.80E-18 Bilirubin levels HPOID:0002904 DOID:2741 G intron GWASdb_trait 2 234396566 rs10929178 G C rs10929178 1.20E-19 Bilirubin levels HPOID:0002904 DOID:2741 G intron GWASdb_trait 2 234396566 rs10929178 G C rs10929178 5.29E-04 Rheumatoid arthritis (ACPA-negative) HPOID:0001370 DOID:7148 G intron GWASdb_trait 2 234398725 rs11683101 T C rs11683101 7.60E-15 Bilirubin levels HPOID:0002904 DOID:2741 T intron GWASdb_trait 2 234406655 rs6704644 G T rs6704644 3.20E-20 Bilirubin levels HPOID:0002904 DOID:2741 G intron GWASdb_trait 2 234406655 rs6704644 G T rs6704644 8.00E-08 Bilirubin levels HPOID:0002904 DOID:2741 G intron GWASdb_trait 2 234425051 rs2603545 C T rs2603545 9.10E-04 Multiple complex diseases HPOID:0000118 NA A intron GWASdb_trait 2 234433081 rs6746234 G A rs6746234 5.20E-20 Bilirubin levels HPOID:0002904 DOID:2741 G intron GWASdb_trait 2 234440053 rs11675858 G A rs11675858 5.30E-20 Bilirubin levels HPOID:0002904 DOID:2741 G intron GWASdb_trait 2 234442949 rs4047189 G T rs4047189 6.00E-23 Bilirubin levels HPOID:0002904 DOID:2741 C intron GWASdb_trait 2 234446511 rs1597940 C T rs1597940 5.70E-04 Multiple complex diseases HPOID:0000118 NA A intron GWASdb_trait 2 234446594 rs1453321 A T rs1453321 4.83E-04 Multiple complex diseases HPOID:0000118 NA T intron GWASdb_trait 2 234449316 rs2167884 G A rs2167884 3.72E-04 Smoking initiation HPOID:0000707 DOID:0050742 C cds-synon GWASdb_trait 2 234450822 rs1901812 T C rs1901812 6.90E-04 Multiple complex diseases HPOID:0000118 NA G intron GWASdb_trait 2 234451486 rs10929208 C T rs10929208 8.28E-04 Multiple complex diseases HPOID:0000118 NA T intron GWASdb_trait 2 234451630 rs11686188 G A rs11686188 4.30E-20 Bilirubin levels HPOID:0002904 DOID:2741 G intron GWASdb_trait 2 234454900 rs4047198 C G rs4047198 3.90E-09 Bilirubin levels HPOID:0002904 DOID:2741 C intron GWASdb_trait 2 234455898 rs6756068 A G rs6756068 1.77E-04 Multiple complex diseases HPOID:0000118 NA A intron GWASdb_trait 2 234456256 rs13385018 C T rs13385018 1.50E-07 Bilirubin levels HPOID:0002904 DOID:2741 C intron GWASdb_trait 2 234456752 rs1542325 C G rs1542325 9.58E-04 Multiple complex diseases HPOID:0000118 NA G intron GWASdb_trait 2 234460968 rs11676524 A T rs11676524 3.90E-20 Bilirubin levels HPOID:0002904 DOID:2741 A intron GWASdb_trait 2 234466843 rs12472244 A G rs12472244 2.20E-14 Bilirubin levels HPOID:0002904 DOID:2741 A intron GWASdb_trait 2 234468148 rs6720619 C A rs6720619 1.43E-04 Smoking initiation HPOID:0000707 DOID:0050742 A intron GWASdb_trait

Disease associated variation - GWAS Central Study Name Source Marker Accession Chromosome Marker Start Marker Stop Alleles Gene Section P-value -log(p-value) GWAS of prostate cancer rs745155 2 234386803 234386803 intronic 0.711057 0.148095583808572

Disease associated variation - OMIM Ensembl_gene_ID Approved Gene Symbol MIM Number ENSG00000085982.13 USP40 610570