PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus DRD3 USP48 24308971 biogrid exp USP48 UACA 22939629 biogrid exp G GP G G G GP G G GP G GP G G G G GP GP G GP G GP GP GP G GP G GP GP G NUP188 USP48 26344197 biogrid exp GP GP G G GP GP G GP GP G GP G GP G G GP GP GP GP G GP G G G GP G GP GP G SEC24D USP48 22863883 biogrid exp GP GP G GP P G GP GP GP GP GP GP G GP P GP GP G G GP GP P GP GP GP GP G NCBP2 USP48 26344197 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G USP48 USP48 19615732 intact exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G USP48 ZFR 22939629 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G SNW1 USP48 20467437 intact exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G MYC USP48 20936779,21150319 i2d,intact exp GP GP G GP P G GP GP GP GP GP GP G GP P GP GP GP GP GP GP GP GP GP GP G APP USP48 21832049 biogrid exp G GP G G GP GP G G GP G G G G G G GP GP G GP G GP GP G G GP G G GP G GPS1 USP48 25486460 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G USP48 VPS35 22863883,22939629 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP G GP G GP GP G HIST1H2BC, HIST1H2BE, HIST1H2BF, HIST1H2BG, HIST1H2BI USP48 25281560 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G CSNK2A1 USP48 25486460 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G BRAT1 USP48 22863883 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP G GP GP GP GP GP GP G HIST1H3A, HIST1H3B, HIST1H3C, HIST1H3D, HIST1H3E, HIST1H3F, HIST1H3G, HIST1H3H, HIST1H3I, HIST1H3J USP48 25281560 biogrid exp P GP G GP P GP P P P P P P P P P P GP GP GP P GP P P USP48 RAPGEF2 20936779 i2d exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PSAP USP48 22863883 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G USP48 DYNC1LI1 26344197 biogrid exp GP GP G G GP GP G G GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G SLC9A3 USP48 24308971 biogrid exp P P P P P USP48 SIRT6 24169447 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G UCHL3 USP48 22939629 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP GP GP GP G NTRK1 USP48 25921289 biogrid exp P P P G P P P P P P P P P P P P P P P UBC USP48 23287719 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G ZC3HAV1 USP48 22939629 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G UBA6 USP48 26344197,22939629 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G GP G USP48 USP21 19615732, 23023127 biogrid,intact exp, pred GP GP G G G GP G GP GP G GP GP GP G G GP GP G GP G GP GP GP G GP G GP GP G EED USP48 ortho GP GP G G G GP G GP GP G GP GP GP GP G GP GP GP GP G GP G GP GP GP GP GP GP G UBC USP48 23023127 pred USP17L8 USP48 23023127 pred USP14 USP48 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G USP48 UBL4B 23023127 pred P P P P P P P P P P P P P P P P P P P P USP8 USP48 23023127 pred G GP G G GP GP G G GP G GP G GP G G GP GP G GP G GP GP G GP GP G GP GP G AXIN1 USP48 23023127 pred GP GP G GP GP G P GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G USP34 USP48 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP G G GP GP GP GP GP GP GP GP G SUMO2 USP48 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G USP48 USP44 23023127 pred P P P P P P P P P P P P P GP G P P P P P P GP UBXN2A USP48 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G SQSTM1 USP48 23023127 pred GP GP G G GP G G G GP G GP GP GP GP G GP G GP GP G GP GP GP GP GP GP GP GP G USP48 USP40 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP G G GP GP GP GP GP G USP17L7 USP48 23023127 pred RAD23A USP48 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G USP48 USP7 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G USP48 UHRF2 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G PARK2 USP48 23023127 pred P GP G P GP G GP GP G GP P P G P GP GP P G P GP GP GP P GP G RAD23B USP48 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G USP48 FAF1 23023127 pred GP GP G G GP GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G USP51 USP48 23023127 pred GP GP G G GP GP G GP P G GP P GP G P GP GP GP G GP GP P P GP P GP

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B USP48 UACA MI:0401(biochemical) 22939629 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_242021 prey bait USP48 VPS35 MI:0401(biochemical)|MI:0401(biochemical) 22863883,22939629 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization)|MI:0403(colocalization) (biogrid)|(biogrid) BIOGRID_304874|BIOGRID_242942 prey|bait bait|prey USP48 ZC3HAV1 MI:0401(biochemical) 22939629 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_241209 bait prey UCHL3 USP48 MI:0401(biochemical) 22939629 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_237069 prey bait BRAT1 USP48 MI:0401(biochemical) 22863883 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_304873 bait prey PSAP USP48 MI:0401(biochemical) 22863883 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_302327 prey bait APP USP48 MI:0096(pull down) 21832049 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_229659 prey bait USP48 UBA6 MI:0401(biochemical) 22939629 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_241681 prey bait SEC24D USP48 MI:0401(biochemical) 22863883 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_303840 prey bait USP48 USP21 MI:0007(anti tag coimmunoprecipitation)|MI:0004(affinity chromatography technology) 19615732 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (intact)|(biogrid) UniProt_100667|BIOGRID_120727 prey|prey bait|bait USP48 CG15642 MI:0004(affinity chromatography technology) 19615732 taxid:9606(Homo sapiens) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (biogrid) BIOGRID_120890 bait prey USP48 ZFR MI:0401(biochemical) 22939629 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_241578 bait prey UBC USP48 MI:0004(affinity chromatography technology)|MI:0415(enzymatic study)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0686(unspecified method)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0415(enzymatic study) 21139048,21890473,21906983,21963094,21987572,22118674,23000965,23287719 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid) BIOGRID_270478|BIOGRID_160606|BIOGRID_166495|BIOGRID_180949|BIOGRID_249566|BIOGRID_171801|BIOGRID_176710|BIOGRID_163967 bait|bait|bait|bait|prey|bait|bait|bait prey|prey|prey|prey|bait|prey|prey|prey

PPI - HINT Gene A Gene B PMID Method Quality UBA6 USP48 26344197,22939629 0401,0401 HT SEC24D USP48 22863883 0401 HT PSAP USP48 22863883 0401 HT UBC USP48 21963094,22118674 0004,0004 LC UCHL3 USP48 22939629 0401 HT NCBP2 USP48 26344197 0401 HT NUP188 USP48 26344197 0401 HT BRAT1 USP48 22863883 0401 HT ZC3HAV1 USP48 22939629 0401 HT USP48 ZFR 22939629 0401 HT USP48 VPS35 22863883,22939629 0401,0401 HT USP48 UACA 22939629 0401 HT USP48 USP21 19615732,19615732 0004,0007 HT USP48 DYNC1LI1 26344197 0401 HT UBA6 USP48 26344197,22939629 0401,0401 HT SEC24D USP48 22863883 0401 HT PSAP USP48 22863883 0401 HT UCHL3 USP48 22939629 0401 HT NCBP2 USP48 26344197 0401 HT NUP188 USP48 26344197 0401 HT BRAT1 USP48 22863883 0401 HT ZC3HAV1 USP48 22939629 0401 HT USP48 ZFR 22939629 0401 HT USP48 VPS35 22863883,22939629 0401,0401 HT USP48 UACA 22939629 0401 HT USP48 USP21 19615732,19615732 0004,0007 HT USP48 DYNC1LI1 26344197 0401 HT UBC USP48 21963094,22118674 0004,0004 LC UBA6 USP48 26344197,22939629 0401,0401 LC SEC24D USP48 22863883 0401 LC PSAP USP48 22863883 0401 LC UCHL3 USP48 22939629 0401 LC DRD3 USP48 24308971,24308971 0004,0018 LC NCBP2 USP48 26344197 0401 LC CSNK2A1 USP48 25486460 0415 LC NUP188 USP48 26344197 0401 LC BRAT1 USP48 22863883 0401 LC ZC3HAV1 USP48 22939629 0401 LC USP48 ZFR 22939629 0401 LC USP48 VPS35 22863883,22939629 0401,0401 LC USP48 UACA 22939629 0401 LC USP48 DYNC1LI1 26344197 0401 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q8N6T7 Q86UV5 SIRT6 USP48 0.126 24169447 Q86UV5 Q6PJG6 USP48 BRAT1 0.081 22863883 Q86UV5 O94855 USP48 SEC24D 0.081 22863883 Q86UV5 P05067 USP48 APP 0.183 21832049 Q86UV5 P07602 USP48 PSAP 0.081 22863883 Q86UV5 P0CG48 USP48 UBC 0.309 23287719 Q86UV5 P15374 USP48 UCHL3 0.081 22939629 Q86UV5 P48764 USP48 SLC9A3 0.21 24308971 Q86UV5 P52298 USP48 NCBP2 0.081 26344197 Q86UV5 Q5SRE5 USP48 NUP188 0.081 26344197 Q86UV5 Q7Z2W4 USP48 ZC3HAV1 0.081 22939629 Q96KR1 Q86UV5 ZFR USP48 0.081 22939629 Q9Y6G9 Q86UV5 DYNC1LI1 USP48 0.081 Q86UV5 P01106 USP48 MYC 0.126 21150319 Q86UV5 P04629 USP48 NTRK1 0.126 25921289 Q9UK80 Q86UV5 USP21 USP48 0.236 19615732 Q86UV5 Q13573 USP48 SNW1 0.236 20467437 Q86UV5 A0AVT1 USP48 UBA6 0.155 26344197,22939629 Q86UV5 P35462 USP48 DRD3 0.454 24308971 Q96QK1 Q86UV5 VPS35 USP48 0.155 22939629,22863883 Q9BZF9 Q86UV5 UACA USP48 0.081 22939629 Q86UV5 P68400 USP48 CSNK2A1 0.309 25486460 Q86UV5 Q13098 USP48 GPS1 0.21 25486460 Q86UV5 P68431 USP48 HIST1H3J 0.126 25281560

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 EED USP48 MI:0362 inference MI:0461 interaction database MYC USP48 MI:0045 experimental interaction detection MI:0461 interaction database NTRK1 USP48 MI:0045 experimental interaction detection MI:0461 interaction database APP USP48 MI:0045 experimental interaction detection MI:0461 interaction database UBC USP48 MI:0045 experimental interaction detection MI:0461 interaction database GJA1 USP48 MI:0362 inference MI:0461 interaction database DRD3 USP48 MI:0045 experimental interaction detection MI:0461 interaction database SLC9A3 USP48 MI:0045 experimental interaction detection MI:0461 interaction database HIST1H2BC USP48 MI:0045 experimental interaction detection MI:0461 interaction database CSNK2A1 USP48 MI:0045 experimental interaction detection MI:0461 interaction database HIST1H3A USP48 MI:0045 experimental interaction detection MI:0461 interaction database TRAF2 USP48 MI:0362 inference MI:1106 pathways database GPS1 USP48 MI:0045 experimental interaction detection MI:0461 interaction database SNW1 USP48 MI:0045 experimental interaction detection MI:0461 interaction database USP48 SIRT6 MI:0045 experimental interaction detection MI:0461 interaction database USP48 USP21 MI:0045 experimental interaction detection MI:0461 interaction database