PTM - CPLM Gene Name UniProt ID Type Position Code HDAC6; KIAA0901; JM21 Q9UBN7 Acetylation 32 K HDAC6; KIAA0901; JM21 Q9UBN7 Acetylation 36 K HDAC6; KIAA0901; JM21 Q9UBN7 Acetylation 37 K HDAC6; KIAA0901; JM21 Q9UBN7 Acetylation 51 K HDAC6; KIAA0901; JM21 Q9UBN7 Acetylation 52 K HDAC6; KIAA0901; JM21 Q9UBN7 Acetylation 53 K HDAC6; KIAA0901; JM21 Q9UBN7 Acetylation 55 K HDAC6; KIAA0901; JM21 Q9UBN7 Acetylation 57 K HDAC6; KIAA0901; JM21 Q9UBN7 Acetylation 58 K HDAC6; KIAA0901; JM21 Q9UBN7 Acetylation 553 K HDAC6; KIAA0901; JM21 Q9UBN7 Acetylation 555 K HDAC6; KIAA0901; JM21 Q9UBN7 Acetylation 849 K HDAC6; KIAA0901; JM21 Q9UBN7 Acetylation 853 K HDAC6; KIAA0901; JM21 Q9UBN7 Acetylation 854 K HDAC6; KIAA0901; JM21 Q9UBN7 Acetylation 872 K HDAC6; KIAA0901; JM21 Q9UBN7 Acetylation 873 K HDAC6; KIAA0901; JM21 Q9UBN7 Ubiquitination 116 K HDAC6; KIAA0901; JM21 Q9UBN7 Ubiquitination 849 K

PTM - dbPAF Gene Name UniProt ID Position Type Species HDAC6; KIAA0901; JM21 Q9UBN7 1003 T Homo sapiens(Human) HDAC6; KIAA0901; JM21 Q9UBN7 1016 T Homo sapiens(Human) HDAC6; KIAA0901; JM21 Q9UBN7 1021 T Homo sapiens(Human) HDAC6; KIAA0901; JM21 Q9UBN7 1027 T Homo sapiens(Human) HDAC6; KIAA0901; JM21 Q9UBN7 1031 T Homo sapiens(Human) HDAC6; KIAA0901; JM21 Q9UBN7 1034 T Homo sapiens(Human) HDAC6; KIAA0901; JM21 Q9UBN7 1035 S Homo sapiens(Human) HDAC6; KIAA0901; JM21 Q9UBN7 1040 T Homo sapiens(Human) HDAC6; KIAA0901; JM21 Q9UBN7 1041 T Homo sapiens(Human) HDAC6; KIAA0901; JM21 Q9UBN7 1048 T Homo sapiens(Human) HDAC6; KIAA0901; JM21 Q9UBN7 1055 T Homo sapiens(Human) HDAC6; KIAA0901; JM21 Q9UBN7 1062 S Homo sapiens(Human) HDAC6; KIAA0901; JM21 Q9UBN7 16 S Homo sapiens(Human) HDAC6; KIAA0901; JM21 Q9UBN7 22 S Homo sapiens(Human) HDAC6; KIAA0901; JM21 Q9UBN7 28 S Homo sapiens(Human) HDAC6; KIAA0901; JM21 Q9UBN7 30 T Homo sapiens(Human) HDAC6; KIAA0901; JM21 Q9UBN7 43 S Homo sapiens(Human) HDAC6; KIAA0901; JM21 Q9UBN7 458 S Homo sapiens(Human) HDAC6; KIAA0901; JM21 Q9UBN7 570 Y Homo sapiens(Human) HDAC6; KIAA0901; JM21 Q9UBN7 846 S Homo sapiens(Human) HDAC6; KIAA0901; JM21 Q9UBN7 847 S Homo sapiens(Human) HDAC6; KIAA0901; JM21 Q9UBN7 868 T Homo sapiens(Human) HDAC6; KIAA0901; JM21 Q9UBN7 923 T Homo sapiens(Human) HDAC6; KIAA0901; JM21 Q9UBN7 925 S Homo sapiens(Human) HDAC6; KIAA0901; JM21 Q9UBN7 993 T Homo sapiens(Human) HDAC6; KIAA0901; JM21 Q9UBN7 995 S Homo sapiens(Human)

PTM - PhosphositePlus UniProt ID MOD_RSD Type SITE_+/-7_AA Q9UBN7 K36-ac Acetylation VtSKRNIkkGAVPRs Q9UBN7 K37-ac Acetylation tSKRNIkkGAVPRsI Q9UBN7 K849-ac Acetylation REGPssSkLVTkkAP Q9UBN7 K853-ac Acetylation ssSkLVTkkAPQPAK Q9UBN7 K854-ac Acetylation sSkLVTkkAPQPAKP Q9UBN7 K873-ac Acetylation RMtTREKkVLEAGMG Q9UBN7 K881-ac Acetylation VLEAGMGkVTSASFG Q9UBN7 S16-p Phosphorylation TTTRQRRsRQNPQsP Q9UBN7 S22-p Phosphorylation RsRQNPQsPPQDSsV Q9UBN7 S28-p Phosphorylation QsPPQDSsVtSKRNI Q9UBN7 T30-p Phosphorylation PPQDSsVtSKRNIkk Q9UBN7 S43-p Phosphorylation kkGAVPRsIPNLAEV Q9UBN7 S412-p Phosphorylation DPCPMLEsPGAPCRS Q9UBN7 S458-p Phosphorylation EEDNVEEsEEEGPWE Q9UBN7 Y570-p Phosphorylation SSNFDSIyICPSTFA Q9UBN7 S846-p Phosphorylation VEDREGPssSkLVTk Q9UBN7 S847-p Phosphorylation EDREGPssSkLVTkk Q9UBN7 T868-p Phosphorylation PRLAERMtTREKkVL Q9UBN7 T923-p Phosphorylation GGATLAQtIsEAAIG Q9UBN7 S925-p Phosphorylation ATLAQtIsEAAIGGA Q9UBN7 T993-p Phosphorylation GGATLAQtTsEAAME Q9UBN7 S995-p Phosphorylation ATLAQtTsEAAMEGA Q9UBN7 T1003-p Phosphorylation EAAMEGAtLDQTTSE Q9UBN7 T1016-p Phosphorylation SEEAPGGtELIQtPL Q9UBN7 T1021-p Phosphorylation GGtELIQtPLASStD Q9UBN7 T1027-p Phosphorylation QtPLASStDHQtPPt Q9UBN7 T1031-p Phosphorylation ASStDHQtPPtsPVQ Q9UBN7 T1034-p Phosphorylation tDHQtPPtsPVQGtt Q9UBN7 S1035-p Phosphorylation DHQtPPtsPVQGttP Q9UBN7 T1040-p Phosphorylation PtsPVQGttPQISPS Q9UBN7 T1041-p Phosphorylation tsPVQGttPQISPSt Q9UBN7 T1048-p Phosphorylation tPQISPStLIGSLRt Q9UBN7 T1055-p Phosphorylation tLIGSLRtLELGSEs Q9UBN7 S1062-p Phosphorylation tLELGSEsQGASESQ Q9UBN7 K116-ub Ubiquitination PERLHAIkEQLIQEG

PTM - dbPTM UniProt ID Position Code Type Resources References Q9UBN7 22 S Phosphorylation Swiss-Prot 1010711 15302935;16964243 Q9UBN7 30 T Phosphorylation Swiss-Prot 1010711 17287340 Q9UBN7 22 S Phosphorylation PhosphoELM.10011 16964243;15302935 Q9UBN7 30 T Phosphorylation PhosphoELM.10011 17287340 Q9UBN7 1088 D Caspase Phosphositeplus.1010730 18722006 Q9UBN7 116 K Ubiquitylation Phosphositeplus.1010730 21906983 Q9UBN7 22 S Phosphorylation Phosphositeplus.1010730 15302935;16964243;22115753 Q9UBN7 458 S Phosphorylation Phosphositeplus.1010730 21486957 Q9UBN7 30 T Phosphorylation Phosphositeplus.1010730 17287340 Q9UBN7 570 Y Phosphorylation Phosphositeplus.1010730 20029029 Q9UBN7 22 S Phosphorylation HPRD 9.0 15302935,16964243 Q9UBN7 30 T Phosphorylation HPRD 9.0 17287340 Q9UBN7 22 S Phosphorylation SysPTM 1.1 15302935 Q9UBN7 30 T Phosphorylation SysPTM 1.1 17287340

PTM - HPRD Symbol Position Code Type References HDAC6 22 S Phosphorylation 15302935,16964243 HDAC6 30 T Phosphorylation 17287340

PTM - Phospho.ELM UniProt Position Code PMIDs Kinase Source Type Q9UBN7 30 T 17287340 HTP Phosphorylation Q9UBN7 22 S 16964243 HTP Phosphorylation Q9UBN7 22 S 15302935 HTP Phosphorylation

PTM - UniProt UniProt ID Position Type PMIDs Q9UBN7 22 Phosphoserine 23186163 Q9UBN7 1016 Phosphothreonine 24275569 Q9UBN7 1021 Phosphothreonine 24275569 Q9UBN7 1027 Phosphothreonine 24275569 Q9UBN7 1031 Phosphothreonine 24275569 Q9UBN7 1034 Phosphothreonine 24275569 Q9UBN7 1035 Phosphoserine 24275569 Q9UBN7 1040 Phosphothreonine 24275569

PTM - BioGRID Entrez Gene BioGRID ID Position Code Type PMIDs 10013 115330 - K Ubiquitination 18781797 10013 115330 - K Ubiquitination 21139048 10013 115330 - K Ubiquitination 21906983 10013 115330 - K Ubiquitination 22492994 10013 115330 - K Neddylation 18247557 10013 115330 - K FAT10ylation 22797925 10013 115330 - K Ubiquitination 24654937 10013 115330 - K Neddylation 24654937 10013 115330 - K Sumoylation 24654937 10013 115330 - K Ubiquitination 24816145

PTM - mUbiSiDa Gene Name Species Ubiquitination Site Ubiquitination Sequence Evidence PMID HDAC6 Homo sapiens (Human) 116 "116,ERLHAIKEQLIQE" 116:21906983 HDAC6 Homo sapiens (Human) 130 "130,ERLHAIKEQLIQE" 130:21906983 HDAC6 Homo sapiens (Human) 116 "116,ERLHAIKEQLIQE" 116:21906983 HDAC6 Homo sapiens (Human) 116 "116,ERLHAIKEQLIQE" 116:21906983 HDAC6 Homo sapiens (Human) 130 "130,ERLHAIKEQLIQE" 130:21906983 HDAC6 Homo sapiens (Human) 116 "116,ERLHAIKEQLIQE" 116:21906983 HDAC6 Homo sapiens (Human) 116 "116,ERLHAIKEQLIQE" 116:21906983 HDAC6 Homo sapiens (Human) 116 "116,ERLHAIKEQLIQE" 116:21906983