PTM - CPLM Gene Name UniProt ID Type Position Code CRKL P46109 Acetylation 253 K CRKL P46109 Ubiquitination 292 K CRKL P46109 Ubiquitination 180 K

PTM - dbPAF Gene Name UniProt ID Position Type Species CRKL P46109 105 Y Homo sapiens(Human) CRKL P46109 107 S Homo sapiens(Human) CRKL P46109 112 S Homo sapiens(Human) CRKL P46109 114 S Homo sapiens(Human) CRKL P46109 127 Y Homo sapiens(Human) CRKL P46109 130 T Homo sapiens(Human) CRKL P46109 132 Y Homo sapiens(Human) CRKL P46109 184 S Homo sapiens(Human) CRKL P46109 185 S Homo sapiens(Human) CRKL P46109 195 S Homo sapiens(Human) CRKL P46109 197 S Homo sapiens(Human) CRKL P46109 198 Y Homo sapiens(Human) CRKL P46109 207 Y Homo sapiens(Human) CRKL P46109 212 T Homo sapiens(Human) CRKL P46109 213 T Homo sapiens(Human) CRKL P46109 214 T Homo sapiens(Human) CRKL P46109 220 S Homo sapiens(Human) CRKL P46109 222 S Homo sapiens(Human) CRKL P46109 228 T Homo sapiens(Human) CRKL P46109 232 S Homo sapiens(Human) CRKL P46109 251 Y Homo sapiens(Human) CRKL P46109 254 T Homo sapiens(Human) CRKL P46109 41 S Homo sapiens(Human) CRKL P46109 42 S Homo sapiens(Human) CRKL P46109 43 T Homo sapiens(Human) CRKL P46109 48 Y Homo sapiens(Human) CRKL P46109 92 Y Homo sapiens(Human) CRKL P46109 95 T Homo sapiens(Human) CRKL P46109 96 T Homo sapiens(Human) CRKL P46109 97 T Homo sapiens(Human)

PTM - PhosphositePlus UniProt ID MOD_RSD Type SITE_+/-7_AA P46109 K180-ac Acetylation IPVPyVEkLVRssPH P46109 K253-ac Acetylation RVPCAyDktALALEV P46109 R11-m1 Methylation ARFDSSDrSAWYMGP P46109 S42-p Phosphorylation MFLVRDSstCPGDyV P46109 T43-p Phosphorylation FLVRDSstCPGDyVL P46109 Y48-p Phosphorylation SstCPGDyVLSVSEN P46109 Y92-p Phosphorylation LEFYKIHyLDtttLI P46109 T95-p Phosphorylation YKIHyLDtttLIEPA P46109 T96-p Phosphorylation KIHyLDtttLIEPAP P46109 T97-p Phosphorylation IHyLDtttLIEPAPR P46109 S107-p Phosphorylation EPAPRYPsPPMGsVs P46109 S112-p Phosphorylation YPsPPMGsVsAPNLP P46109 S114-p Phosphorylation sPPMGsVsAPNLPTA P46109 Y127-p Phosphorylation TAEDNLEyVRtLyDF P46109 T130-p Phosphorylation DNLEyVRtLyDFPGN P46109 Y132-p Phosphorylation LEyVRtLyDFPGNDA P46109 Y177-p Phosphorylation VGMIPVPyVEkLVRs P46109 S184-p Phosphorylation yVEkLVRssPHGKHG P46109 S185-p Phosphorylation VEkLVRssPHGKHGN P46109 S195-p Phosphorylation GKHGNRNsNsyGIPE P46109 S197-p Phosphorylation HGNRNsNsyGIPEPA P46109 Y198-p Phosphorylation GNRNsNsyGIPEPAH P46109 Y207-p Phosphorylation IPEPAHAyAQPQttt P46109 T212-p Phosphorylation HAyAQPQtttPLPAV P46109 T213-p Phosphorylation AyAQPQtttPLPAVs P46109 T214-p Phosphorylation yAQPQtttPLPAVsG P46109 S220-p Phosphorylation ttPLPAVsGsPGAAI P46109 S222-p Phosphorylation PLPAVsGsPGAAItP P46109 T228-p Phosphorylation GsPGAAItPLPsTQN P46109 S232-p Phosphorylation AAItPLPsTQNGPVF P46109 Y251-p Phosphorylation QKRVPCAyDktALAL P46109 T254-p Phosphorylation VPCAyDktALALEVG P46109 K180-ub Ubiquitination IPVPyVEkLVRssPH P46109 K292-ub Ubiquitination LFPFTHVkIFDPQNP

PTM - dbPTM UniProt ID Position Code Type Resources References P46109 127 Y Phosphorylation Swiss-Prot 1010711 19690332 P46109 132 Y Phosphorylation Swiss-Prot 1010711 17389395;19534553 P46109 198 Y Phosphorylation Swiss-Prot 1010711 17389395 P46109 207 Y Phosphorylation Swiss-Prot 1010711 15592455;19534553 P46109 251 Y Phosphorylation Swiss-Prot 1010711 15592455;19534553 P46109 197 S Phosphorylation PhosphoELM.10011 18669648 P46109 212 T Phosphorylation PhosphoELM.10011 18669648 P46109 198 Y Phosphorylation PhosphoELM.10011 18669648 P46109 207 Y Phosphorylation PhosphoELM.10011 9710592 P46109 292 K Ubiquitylation Phosphositeplus.1010730 21890473 P46109 184 S Phosphorylation Phosphositeplus.1010730 20068231;21406692 P46109 220 S Phosphorylation Phosphositeplus.1010730 20007894 P46109 42 S Phosphorylation Phosphositeplus.1010730 20736484 P46109 43 T Phosphorylation Phosphositeplus.1010730 20736484 P46109 127 Y Phosphorylation Phosphositeplus.1010730 18083107;18180459;19690332;22115753 P46109 132 Y Phosphorylation Phosphositeplus.1010730 17016520;17389395;17646646;18083107;18180459;19534553;19690332;20007894;20736484 P46109 198 Y Phosphorylation Phosphositeplus.1010730 17016520;17389395;18180459;20007894;20562096;20736484;21403953 P46109 207 Y Phosphorylation Phosphositeplus.1010730 10608804;15256422;15268851;15592455;16424036;17016520;18180459;19061839;19534553;19901323;20007894;21209314;21253578;21403953;21447384;22169110;9053848;9710592 P46109 251 Y Phosphorylation Phosphositeplus.1010730 17016520;18083107;18180459;19534553;19605366;20090780;20736484;21253578;21403953;21447384 P46109 41 S Phosphorylation HPRD 9.0 20230923 P46109 42 S Phosphorylation HPRD 9.0 20230923 P46109 107 S Phosphorylation HPRD 9.0 15345747 P46109 184 S Phosphorylation HPRD 9.0 20068231 P46109 195 S Phosphorylation HPRD 9.0 20068231 P46109 197 S Phosphorylation HPRD 9.0 18669648 P46109 222 S Phosphorylation HPRD 9.0 20068231 P46109 43 T Phosphorylation HPRD 9.0 20230923 P46109 212 T Phosphorylation HPRD 9.0 18669648 P46109 132 Y Phosphorylation HPRD 9.0 17389395,17016520 P46109 198 Y Phosphorylation HPRD 9.0 18669648,17389395,17016520 P46109 207 Y Phosphorylation HPRD 9.0 9053848,17016520,19901323,20068231 P46109 251 Y Phosphorylation HPRD 9.0 17016520 P46109 132 Y Phosphorylation SysPTM 1.1 17389395 P46109 198 Y Phosphorylation SysPTM 1.1 17389395

PTM - HPRD Symbol Position Code Type References CRKL 107 S Phosphorylation 15345747 CRKL 132 Y Phosphorylation 17389395,17016520 CRKL 184 S Phosphorylation 20068231 CRKL 195 S Phosphorylation 20068231 CRKL 197 S Phosphorylation 18669648 CRKL 198 Y Phosphorylation 18669648,17389395,17016520 CRKL 207 Y Phosphorylation 9053848,17016520,19901323,20068231 CRKL 212 T Phosphorylation 18669648 CRKL 222 S Phosphorylation 20068231 CRKL 251 Y Phosphorylation 17016520 CRKL 41 S Phosphorylation 20230923 CRKL 42 S Phosphorylation 20230923 CRKL 43 T Phosphorylation 20230923

PTM - Phospho.ELM UniProt Position Code PMIDs Kinase Source Type P46109 212 T 18669648 HTP Phosphorylation P46109 197 S 18669648 HTP Phosphorylation P46109 198 Y 18669648 HTP Phosphorylation P46109 207 Y 9710592 Abl LTP Phosphorylation

PTM - UniProt UniProt ID Position Type PMIDs P46109 127 Phosphotyrosine 19690332 P46109 207 Phosphotyrosine 15592455

PTM - PHOSIDA Symbol Accession Code Position Surrounding Sequence Type CRKL IPI00004839 S 184 VEKLVRpSSPHGKH phosphorylation

PTM - BioGRID Entrez Gene BioGRID ID Position Code Type PMIDs 1399 107789 - K Ubiquitination 21139048 1399 107789 - K Ubiquitination 21890473 1399 107789 - K Ubiquitination 12671687 1399 107789 - K Ubiquitination 12697763 1399 107789 - K Ubiquitination 24816145

PTM - mUbiSiDa Gene Name Species Ubiquitination Site Ubiquitination Sequence Evidence PMID CRKL Homo sapiens (Human) 292 "292,FPFTHVKIFDPQN" 292:21890473