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PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants B2RDW1 P54578 - - - X 2 P54578 anti tag coimmunoprecipitation 19490896 association C 32 P54578 anti tag coimmunoprecipitation 24811749 association C 66 P54578 anti tag coimmunoprecipitation 19615732 physical association C 26 P54578 A0A024R7W9 two hybrid 18624398 physical association X 2 P54578 A0M8W4 two hybrid 19549727 physical association X 2 P54578 pull down 19896943 association C 3 P54578 anti tag coimmunoprecipitation 19615732 physical association C 31 P54578 P30480 anti bait coimmunoprecipitation 17353931 physical association X 2 P54578 Q08209 anti tag coimmunoprecipitation 19896943 physical association X 2 P54578 Q08209 anti tag coimmunoprecipitation 19896943 physical association X 2 P54578 Q08209 fluorescence microscopy 19896943 colocalization X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B PSMA3 USP14 MI:0004(affinity chromatography technology) 22079093 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_156036 bait prey USP14 PSMD4 MI:0007(anti tag coimmunoprecipitation)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 19349277,19615732 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (intact)|(biogrid)|(biogrid) UniProt_100661|BIOGRID_199566|BIOGRID_119728 bait|prey|bait prey|bait|prey USP14 COPS5 MI:0018(two hybrid)|MI:0018(two hybrid) 18624398 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_155275|UniProt_96592 prey|prey bait|bait PSMC3 USP14 MI:0007(anti tag coimmunoprecipitation)|MI:0004(affinity chromatography technology)|MI:0401(biochemical) 19615732,22939629 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0403(colocalization) (intact)|(biogrid)|(biogrid) UniProt_100661|BIOGRID_119705|BIOGRID_233852 prey|prey|bait bait|bait|prey USP14 RAD23A MI:0415(enzymatic study) 19013454 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_188744 prey bait PSMC4 USP14 MI:0004(affinity chromatography technology)|MI:0401(biochemical)|MI:0007(anti tag coimmunoprecipitation) 19615732,22939629 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0403(colocalization)|MI:0915(physical association) (biogrid)|(biogrid)|(intact) BIOGRID_119708|BIOGRID_233790|UniProt_100661 prey|bait|prey bait|prey|bait UBC USP14 MI:0415(enzymatic study)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0415(enzymatic study)|MI:0004(affinity chromatography technology)|MI:0686(unspecified method)|MI:0114(x-ray crystallography)|MI:0096(pull down) 16196087,16211010,18781797,21139048,21890473,21906983,21963094,21987572,22053931,22118674,22505724,23000965,23287719,23801757 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0914(association)|MI:0407(direct interaction) (biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid) BIOGRID_163205|BIOGRID_162013|BIOGRID_175802|BIOGRID_225466|BIOGRID_142959|BIOGRID_181259|BIOGRID_222359|BIOGRID_172152|BIOGRID_265075|BIOGRID_160442|BIOGRID_268854|BIOGRID_249563|BIOGRID_197222|BIOGRID_283219 bait|bait|bait|bait|bait|bait|bait|bait|bait|bait|bait|prey|prey|bait prey|prey|prey|prey|prey|prey|prey|prey|prey|prey|prey|bait|bait|prey USP14 USP7 MI:0004(affinity chromatography technology)|MI:0007(anti tag coimmunoprecipitation) 19615732 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_120008|UniProt_100684 prey|prey bait|bait USP14 PSMC1 MI:0004(affinity chromatography technology)|MI:0007(anti tag coimmunoprecipitation) 19615732 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_119698|UniProt_100661 bait|bait prey|prey USP14 PSMC5 MI:0004(affinity chromatography technology)|MI:0401(biochemical)|MI:0007(anti tag coimmunoprecipitation) 17646385,19615732 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid)|(intact) BIOGRID_119711|BIOGRID_188257|UniProt_100661 bait|prey|bait prey|bait|prey PSMD12 USP14 MI:0007(anti tag coimmunoprecipitation)|MI:0401(biochemical)|MI:0004(affinity chromatography technology) 19615732,22939629 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0403(colocalization)|MI:0915(physical association) (intact)|(biogrid)|(biogrid) UniProt_100661|BIOGRID_233815|BIOGRID_119746 prey|bait|prey bait|prey|bait USP14 PSMC6 MI:0007(anti tag coimmunoprecipitation)|MI:0004(affinity chromatography technology)|MI:0401(biochemical) 19615732,22939629 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0403(colocalization) (intact)|(biogrid)|(biogrid) UniProt_100661|BIOGRID_119714|BIOGRID_233804 bait|bait|prey prey|prey|bait PSMD7 USP14 MI:0004(affinity chromatography technology)|MI:0401(biochemical)|MI:0007(anti tag coimmunoprecipitation) 19615732,22939629 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0403(colocalization)|MI:0915(physical association) (biogrid)|(biogrid)|(intact) BIOGRID_119731|BIOGRID_233774|UniProt_100661 prey|bait|prey bait|prey|bait USP14 RPL30 MI:0401(biochemical) 22863883 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_304863 prey bait USP14 RPL23 MI:0401(biochemical) 22863883 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_304862 prey bait PSMD14 USP14 MI:0007(anti tag coimmunoprecipitation)|MI:0401(biochemical)|MI:0004(affinity chromatography technology) 19615732,22939629 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0403(colocalization)|MI:0915(physical association) (intact)|(biogrid)|(biogrid) UniProt_100661|BIOGRID_233849|BIOGRID_120146 prey|bait|prey bait|prey|bait ECHS1 USP14 MI:0401(biochemical) 22863883 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_299448 prey bait USP14 UBE2N MI:0401(biochemical) 22939629 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_243652 prey bait USP14 CXCR4 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 19106094 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_116214|BIOGRID_116213 prey|prey bait|bait USP14 SUMO2 MI:0004(affinity chromatography technology) 19471022 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_183448 prey bait USP14 HNRNPK MI:0401(biochemical) 22939629 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_238697 prey bait PSMC2 USP14 MI:0004(affinity chromatography technology)|MI:0007(anti tag coimmunoprecipitation) 19615732 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_119702|UniProt_100661 prey|prey bait|bait USP14 PPP3CA MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation) 19896943 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization)|MI:0403(colocalization)|MI:0915(physical association)|MI:0915(physical association)|MI:0403(colocalization)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) MI:0471(mint)|MI:0471(mint)|MI:0471(mint)|MI:0471(mint)|(intact)|(intact)|(intact)|MI:0471(mint)|MI:0471(mint) MINT_74377|MINT_44091|MINT_74376|MINT_44090|UniProt_104023|UniProt_104022|UniProt_104021|MINT_44089|MINT_74375 neutral component|neutral component|bait|bait|neutral component|bait|bait|bait|bait neutral component|neutral component|prey|prey|neutral component|prey|prey|prey|prey USP14 XPO7 MI:0401(biochemical) 22939629 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_241807 bait prey ERN1 USP14 MI:0018(two hybrid)|MI:0018(two hybrid) 19135427 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_197568|BIOGRID_197570 bait|bait prey|prey USP14 PSMA6 MI:0007(anti tag coimmunoprecipitation)|MI:0004(affinity chromatography technology) 19615732 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (intact)|(biogrid) UniProt_100661|BIOGRID_119689 bait|bait prey|prey TXNL1 USP14 MI:0007(anti tag coimmunoprecipitation)|MI:0004(affinity chromatography technology) 19615732 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (intact)|(biogrid) UniProt_100661|BIOGRID_120046 prey|prey bait|bait USP14 USP21 MI:0415(enzymatic study) 22626734 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_223084 prey bait USP14 FANCC MI:0018(two hybrid) 14499622 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_85835 prey bait PSMD3 USP14 MI:0007(anti tag coimmunoprecipitation)|MI:0004(affinity chromatography technology) 19615732 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (intact)|(biogrid) UniProt_100661|BIOGRID_119725 prey|prey bait|bait USP14 PSMD13 MI:0004(affinity chromatography technology)|MI:0401(biochemical)|MI:0007(anti tag coimmunoprecipitation) 19615732,22939629 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0403(colocalization)|MI:0915(physical association) (biogrid)|(biogrid)|(intact) BIOGRID_119751|BIOGRID_233797|UniProt_100661 bait|prey|bait prey|bait|prey PSMA2 USP14 MI:0004(affinity chromatography technology) 19193609 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_200349 bait prey USP14 UNC45A MI:0401(biochemical) 22939629 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_236935 bait prey USP14 WDR12 MI:0401(biochemical) 22939629 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_237428 bait prey USP14 VPS37B MI:0401(biochemical) 22939629 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_237717 bait prey PSMB5 USP14 MI:0007(anti tag coimmunoprecipitation)|MI:0004(affinity chromatography technology) 19615732 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (intact)|(biogrid) UniProt_100661|BIOGRID_119693 prey|prey bait|bait USP14 UBE2V2 MI:0018(two hybrid) 19549727 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (intact) UniProt_100878 prey bait USP14 ADRM1 MI:0004(affinity chromatography technology)|MI:0007(anti tag coimmunoprecipitation) 19615732 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_120235|UniProt_100661 bait|bait prey|prey USP14 USP28 MI:0415(enzymatic study) 22626734 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_223127 prey bait XPO1 USP14 MI:0401(biochemical) 22939629 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_241800 prey bait USP14 CNDP2 MI:0401(biochemical) 22863883 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_304860 prey bait RAP1GDS1 USP14 MI:0401(biochemical) 22863883 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_302953 prey bait PFAS USP14 MI:0401(biochemical) 22939629 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_238010 bait prey USP14 PSMD6 MI:0004(affinity chromatography technology)|MI:0007(anti tag coimmunoprecipitation) 19615732 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_120107|UniProt_100661 bait|bait prey|prey USP14 UCHL5 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation) 19490896,19615732 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0914(association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid)|(intact)|(intact)|(intact) BIOGRID_120453|BIOGRID_120007|UniProt_100593|UniProt_100657|UniProt_100661 bait|prey|prey|prey|bait prey|bait|bait|bait|prey USP14 SRPRB MI:0007(anti tag coimmunoprecipitation)|MI:0004(affinity chromatography technology) 19615732 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (intact)|(biogrid) UniProt_100661|BIOGRID_120620 bait|bait prey|prey USP14 USP15 MI:0415(enzymatic study) 22626734 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_223102 prey bait USP14 RNF11 MI:0004(affinity chromatography technology) 23751493 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_282477 prey bait HLA-B USP14 MI:0006(anti bait coimmunoprecipitation) 17353931 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (intact) UniProt_150093 bait prey PSMD11 USP14 MI:0007(anti tag coimmunoprecipitation)|MI:0004(affinity chromatography technology) 19615732 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (intact)|(biogrid) UniProt_100661|BIOGRID_119740 prey|prey bait|bait GSS USP14 MI:0401(biochemical) 22863883 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_304861 bait prey USP14 UBE3A MI:0401(biochemical) 22939629 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_238369 prey bait USP14 PSMD2 MI:0007(anti tag coimmunoprecipitation)|MI:0004(affinity chromatography technology) 19615732 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (intact)|(biogrid) UniProt_100661|BIOGRID_119721 bait|bait prey|prey PSMD10 USP14 MI:0004(affinity chromatography technology)|MI:0007(anti tag coimmunoprecipitation) 19615732 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_119736|UniProt_100661 prey|prey bait|bait USP14 PSMD1 MI:0007(anti tag coimmunoprecipitation)|MI:0004(affinity chromatography technology) 19615732 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (intact)|(biogrid) UniProt_100661|BIOGRID_119718 bait|bait prey|prey USP14 RGPD5 MI:0007(anti tag coimmunoprecipitation)|MI:0004(affinity chromatography technology) 19615732 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (intact)|(biogrid) UniProt_100661|BIOGRID_120729 bait|bait prey|prey

PPI - HINT Gene A Gene B PMID Method Quality PSMD11 USP14 19615732,26344197,19615732 0004,0401,0007 HT PSMD12 USP14 19615732,26344197,19615732,22939629 0004,0401,0007,0401 HT PSMD14 USP14 19615732,26344197,19615732,22939629 0004,0401,0007,0401 HT XPO1 USP14 22939629 0401 HT PFAS USP14 22939629 0401 HT PSMD3 USP14 19615732,19615732 0004,0007 HT TXNL1 USP14 19615732,19615732 0004,0007 HT CCDC22 USP14 26344197 0401 HT ERN1 USP14 19135427,19135427,24951540 0018,0004,0004 LC PSMD10 USP14 19615732,19615732 0004,0007 HT UBC USP14 23801757,22118674 0096,0004 LC PSMC3 USP14 19615732,26344197,19615732,22939629 0004,0401,0007,0401 HT PSMB5 USP14 19615732,19615732 0004,0007 HT ECHS1 USP14 22863883 0401 HT PSMC2 USP14 19615732,19615732 0004,0007 HT PSMC4 USP14 19615732,19615732,22939629 0004,0007,0401 HT PSMD8 USP14 19615732 0007 HT PSMD7 USP14 19615732,26344197,19615732,22939629 0004,0401,0007,0401 HT USP14 PSMD4 19615732,19349277,19615732 0004,0004,0007 HT,LC USP14 PSMA6 19615732,19615732 0004,0007 HT USP14 PSMC1 26496610,19615732,19615732,26496610 0007,0004,0007,0004 HT USP14 PSMC5 17646385,26344197,19615732,19615732 0004,0401,0007,0004 LC,HT USP14 PSMC6 19615732,26344197,19615732,22939629 0004,0401,0007,0401 HT USP14 RPL23 22863883 0401 HT USP14 RPL30 22863883 0401 HT USP14 UBE3A 22939629 0401 HT USP14 BCL2L1 26710889,25429837 0004,0004 LC USP14 PSMD2 19615732,19615732,24951540 0004,0007,0004 HT,LC USP14 PSMD6 19615732,19615732 0004,0007 HT USP14 ADRM1 19615732,19615732 0004,0007 HT USP14 HLA-B 17353931 0006 HT USP14 HNRPK 22939629 0401 HT USP14 Q6U7G8 22863883 0401 HT USP14 NAPRT 26344197 0401 HT USP14 Q8N8M9 26344197 0401 HT USP14 CHMP7 26344197 0401 HT USP14 NDRG1 26344197 0401 HT USP14 USP7 19615732,19615732 0004,0007 HT USP14 CNDP2 22863883 0401 HT USP14 PSMD1 19615732,19615732,26344197 0004,0007,0401 HT USP14 RGPD5|RGPD6 19615732,19615732 0004,0007 HT USP14 WDR12 22939629 0401 HT USP14 UNC45A 22939629 0401 HT USP14 VPS37B 22939629 0401 HT USP14 XPO7 26344197,22939629 0401,0401 HT USP14 PSMD13 19615732,26344197,19615732,22939629 0004,0401,0007,0401 HT USP14 SH3GLB1 26344197 0401 HT USP14 UCHL5 19490896,19615732,19615732 0007,0004,0007 LC,HT USP14 SRPRB 19615732,19615732 0004,0007 HT USP14 HEL-S-71 22939629 0401 HT USP14 HEL-S-102 26344197 0401 HT USP14 HEL-S-114 19615732 0004 HT USP14 HEL161 19615732 0004 HT USP14 HEL-S-64P 22863883 0401 HT PSMD11 USP14 19615732,26344197,19615732 0004,0401,0007 HT PSMD12 USP14 19615732,26344197,19615732,22939629 0004,0401,0007,0401 HT PSMD14 USP14 19615732,26344197,19615732,22939629 0004,0401,0007,0401 HT XPO1 USP14 22939629 0401 HT PFAS USP14 22939629 0401 HT PSMD3 USP14 19615732,19615732 0004,0007 HT TXNL1 USP14 19615732,19615732 0004,0007 HT CCDC22 USP14 26344197 0401 HT PSMD10 USP14 19615732,19615732 0004,0007 HT PSMC3 USP14 19615732,26344197,19615732,22939629 0004,0401,0007,0401 HT PSMB5 USP14 19615732,19615732 0004,0007 HT ECHS1 USP14 22863883 0401 HT PSMC2 USP14 19615732,19615732 0004,0007 HT PSMC4 USP14 19615732,19615732,22939629 0004,0007,0401 HT PSMD8 USP14 19615732 0007 HT PSMD7 USP14 19615732,26344197,19615732,22939629 0004,0401,0007,0401 HT USP14 PSMD4 19615732,19615732 0004,0007 HT USP14 PSMA6 19615732,19615732 0004,0007 HT USP14 PSMC1 26496610,19615732,19615732,26496610 0007,0004,0007,0004 HT USP14 PSMC5 26344197,19615732,19615732 0401,0007,0004 HT USP14 PSMC6 19615732,26344197,19615732,22939629 0004,0401,0007,0401 HT USP14 RPL23 22863883 0401 HT USP14 RPL30 22863883 0401 HT USP14 UBE3A 22939629 0401 HT USP14 PSMD2 19615732,19615732 0004,0007 HT USP14 PSMD6 19615732,19615732 0004,0007 HT USP14 ADRM1 19615732,19615732 0004,0007 HT USP14 HLA-B 17353931 0006 HT USP14 HNRPK 22939629 0401 HT USP14 Q6U7G8 22863883 0401 HT USP14 NAPRT 26344197 0401 HT USP14 Q8N8M9 26344197 0401 HT USP14 CHMP7 26344197 0401 HT USP14 NDRG1 26344197 0401 HT USP14 USP7 19615732,19615732 0004,0007 HT USP14 CNDP2 22863883 0401 HT USP14 PSMD1 19615732,19615732,26344197 0004,0007,0401 HT USP14 RGPD5|RGPD6 19615732,19615732 0004,0007 HT USP14 WDR12 22939629 0401 HT USP14 UNC45A 22939629 0401 HT USP14 VPS37B 22939629 0401 HT USP14 XPO7 26344197,22939629 0401,0401 HT USP14 PSMD13 19615732,26344197,19615732,22939629 0004,0401,0007,0401 HT USP14 SH3GLB1 26344197 0401 HT USP14 UCHL5 19615732,19615732 0004,0007 HT USP14 SRPRB 19615732,19615732 0004,0007 HT USP14 HEL-S-71 22939629 0401 HT USP14 HEL-S-102 26344197 0401 HT USP14 HEL-S-114 19615732 0004 HT USP14 HEL161 19615732 0004 HT USP14 HEL-S-64P 22863883 0401 HT ERN1 USP14 19135427,19135427,24951540 0018,0004,0004 LC UBC USP14 23801757,22118674 0096,0004 LC USP14 PSMD4 19349277 0004 LC USP14 PSMC5 17646385 0004 LC USP14 BCL2L1 26710889,25429837 0004,0004 LC USP14 PSMD2 24951540 0004 LC USP14 UCHL5 19490896 0007 LC B4E3W2 USP14 14499622 0018 LC PSMD11 USP14 26344197 0401 LC PSMD12 USP14 26344197,22939629 0401,0401 LC PSMD14 USP14 26344197,22939629 0401,0401 LC XPO1 USP14 22939629 0401 LC PFAS USP14 22939629 0401 LC CCDC22 USP14 26344197 0401 LC ERN1 USP14 19135427,19135427 0018,0004 LC UBC USP14 27066941,16211010 0415,0114 LC CCNB1 USP14 27074503 0415 LC PSMC3 USP14 26344197,22939629 0401,0401 LC ECHS1 USP14 22863883 0401 LC PSMC4 USP14 22939629 0401 LC PSMD7 USP14 26344197,22939629 0401,0401 LC USP14 USP14 16211010 0114 LC USP14 PSMC5 26344197 0401 LC USP14 PSMC6 26344197,22939629 0401,0401 LC USP14 RPL23 22863883 0401 LC USP14 RPL30 22863883 0401 LC USP14 FANCC 14499622 0018 LC USP14 UBE3A 22939629 0401 LC USP14 PPP3CA 19896943,19896943 0416,0007 LC USP14 UBE2V2 19549727 0018 HT USP14 HNRPK 22939629 0401 LC USP14 Q6U7G8 22863883 0401 LC USP14 NAPRT 26344197 0401 LC USP14 Q8N8M9 26344197 0401 LC USP14 CHMP7 26344197 0401 LC USP14 NDRG1 26344197 0401 LC USP14 COPS5 18624398 0018 HT USP14 CNDP2 22863883 0401 LC USP14 USP28 22626734 0415 HT USP14 PSMD1 26344197 0401 LC USP14 WDR12 22939629 0401 LC USP14 UNC45A 22939629 0401 LC USP14 VPS37B 22939629 0401 LC USP14 XPO7 26344197,22939629 0401,0401 LC USP14 USP21 22626734 0415 HT USP14 PSMD13 26344197,22939629 0401,0401 LC USP14 SH3GLB1 26344197 0401 LC USP14 USP15 22626734 0415 HT USP14 HEL-S-71 22939629 0401 LC USP14 HEL-S-102 26344197 0401 LC USP14 HEL-S-64P 22863883 0401 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID P54578 O15067 USP14 PFAS 0.081 22939629 P61088 P54578 UBE2N USP14 0.081 22939629 P61978 P54578 HNRNPK USP14 0.081 22939629 P62191 P54578 PSMC1 USP14 0.332 26496610,19615732 P62195 P54578 PSMC5 USP14 0.396 19615732,17646385 P62333 P54578 PSMC6 USP14 0.298 19615732,26344197 P54578 P25787 USP14 PSMA2 0.126 19193609 P54578 P25788 USP14 PSMA3 0.126 22079093 Q9Y4E8 P54578 USP15 USP14 0.183 22626734 Q9Y3C5 P54578 RNF11 USP14 0.21 23751493 Q9Y371 P54578 SH3GLB1 USP14 0.081 26344197 P54578 P0CG48 USP14 UBC 0.61 23287719,23801757,27066941 P54578 P04629 USP14 NTRK1 0.126 25921289 Q93009 P54578 USP7 USP14 0.236 19615732 Q99JI4 P54578 PSMD6 USP14 0.236 26496610 P54578 O43396 USP14 TXNL1 0.236 19615732 P54578 O43242 USP14 PSMD3 0.236 19615732 P54578 O00487 USP14 PSMD14 0.236 19615732 P54578 O00232 USP14 PSMD12 0.236 19615732 P54578 O00231 USP14 PSMD11 0.236 19615732 P54578 P43686 USP14 PSMC4 0.236 19615732 P54578 O75832 USP14 PSMD10 0.236 19615732 P54578 P35998 USP14 PSMC2 0.236 19615732 P54578 P28074 USP14 PSMB5 0.236 19615732 Q07817 P54578 BCL2L1 USP14 0.376 26710889,25429837 P60900 P54578 PSMA6 USP14 0.236 19615732 P54578 P51665 USP14 PSMD7 0.236 19615732 Q9UNM6 P54578 PSMD13 USP14 0.236 19615732 Q16186 P54578 ADRM1 USP14 0.236 19615732 Q15008 P54578 PSMD6 USP14 0.236 19615732 Q9UIA9 P54578 XPO7 USP14 0.155 26344197,22939629 Q99460 P54578 PSMD1 USP14 0.236 19615732 Q99666 P54578 RGPD6 USP14 0.236 19615732 Q9Y5M8 P54578 SRPRB USP14 0.236 19615732 Q9Y5K5 P54578 UCHL5 USP14 0.554 19490896,19615732 P60896 P54578 SHFM1 USP14 0.236 24811749 P61073 P54578 CXCR4 USP14 0.454 19106094 Q13200 P54578 PSMD2 USP14 0.396 19615732,24951540 P54578 P17980 USP14 PSMC3 0.298 19615732,26344197 Q92905 P54578 COPS5 USP14 0.332 18624398 P54578 P30480 USP14 HLA-B 0.236 17353931 Q96KP4 P54578 CNDP2 USP14 0.081 22863883 Q96RU2 P54578 USP28 USP14 0.183 22626734 Q9C0B0 P54578 UNK USP14 0.126 25737280 Q9UBS5 P54578 GABBR1 USP14 0.21 26817839 Q9UBU9 P54578 NXF1 USP14 0.126 22658674 Q9UK80 P54578 USP21 USP14 0.183 22626734 P62829 P54578 RPL23 USP14 0.081 22863883 P62888 P54578 RPL30 USP14 0.081 22863883 P54578 P48637 USP14 GSS 0.081 22863883 P54578 P42858 USP14 HTT 0.21 24951540 P63098 P54578 PPP3R1 USP14 0.21 19896943 Q00597 P54578 FANCC USP14 0.183 14499622 Q15819 P54578 UBE2V2 USP14 0.332 19549727 P54578 O14980 USP14 XPO1 0.081 22939629 P54578 O60826 USP14 CCDC22 0.081 26344197 P54578 O75460 USP14 ERN1 0.569 24951540,19135427 P54578 P04792 USP14 HSPB1 0.081 26344197 P54578 P14635 USP14 CCNB1 0.309 27074503 P54578 P24868 USP14 CLB1 0.309 17018280 P54578 P30084 USP14 ECHS1 0.081 22863883 P54578 P48556 USP14 PSMD8 0.126 19615732 P54578 P52306 USP14 RAP1GDS1 0.081 22863883 P54578 P53367 USP14 ARFIP1 0.081 26344197 Q08209 P54578 PPP3CA USP14 0.454 19896943 Q6XQN6 P54578 NAPRT1 USP14 0.081 26344197 Q8WUX9 P54578 CHMP7 USP14 0.081 26344197 Q9GZL7 P54578 WDR12 USP14 0.081 22939629 Q9H3U1 P54578 UNC45A USP14 0.081 22939629 Q9H9H4 P54578 VPS37B USP14 0.081 22939629 P54725 P54578 RAD23A USP14 0.126 19013454 P55036 P54578 PSMD4 USP14 0.396 19615732,19349277 Q05086 P54578 UBE3A USP14 0.081 22939629

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 PSMB11 USP14 MI:0362 inference MI:1106 pathways database PSMD11 USP14 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database PSMD12 USP14 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database PSMD9 USP14 MI:0362 inference MI:1106 pathways database PSMD14 USP14 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database PSMA7 USP14 MI:0362 inference MI:0461,MI:1106 interaction database,pathways database PSMD3 USP14 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database TXNL1 USP14 MI:0045 experimental interaction detection MI:0461 interaction database DNAJA2 USP14 MI:0362 inference MI:0461 interaction database ULK1 USP14 MI:0362 inference MI:0461 interaction database ERN1 USP14 MI:0045 experimental interaction detection MI:0461 interaction database EED USP14 MI:0362 inference MI:0461 interaction database WDHD1 USP14 MI:0362 inference MI:0461 interaction database PSMD10 USP14 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database GFPT2 USP14 MI:0362 inference MI:0461 interaction database CCNB2 USP14 MI:0362 inference MI:0461 interaction database HSPA4L USP14 MI:0362 inference MI:0461 interaction database PGK1 USP14 MI:0362 inference MI:0461 interaction database TUBB4A USP14 MI:0362 inference MI:0461 interaction database NTRK1 USP14 MI:0045 experimental interaction detection MI:0461 interaction database PGK2 USP14 MI:0362 inference MI:0461 interaction database TUBB USP14 MI:0362 inference MI:0461 interaction database UBC USP14 MI:0045 experimental interaction detection MI:0461 interaction database HSPA1A USP14 MI:0362 inference MI:0461 interaction database HSPA1B USP14 MI:0362 inference MI:0461 interaction database HSPA8 USP14 MI:0362 inference MI:0461 interaction database DMD USP14 MI:0362 inference MI:0461 interaction database PSKH1 USP14 MI:0362 inference MI:0461 interaction database CCNB1 USP14 MI:0362 inference MI:0461 interaction database GABRA1 USP14 MI:0362 inference MI:0461 interaction database HSPA6 USP14 MI:0362 inference MI:0461 interaction database PRKACA USP14 MI:0362 inference MI:0461 interaction database PSMC3 USP14 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database RCC1 USP14 MI:0362 inference MI:0461 interaction database PSMB1 USP14 MI:0362 inference MI:0461,MI:1106 interaction database,pathways database TAF1 USP14 MI:0045 experimental interaction detection MI:0461 interaction database PRKACG USP14 MI:0362 inference MI:0461 interaction database PRKACB USP14 MI:0362 inference MI:0461 interaction database PSMA1 USP14 MI:0362 inference MI:0461,MI:1106 interaction database,pathways database PSMA2 USP14 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database PSMA3 USP14 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database PSMA4 USP14 MI:0362 inference MI:0461,MI:1106 interaction database,pathways database PSMB8 USP14 MI:0362 inference MI:0461,MI:1106 interaction database,pathways database PSMB9 USP14 MI:0362 inference MI:0461,MI:1106 interaction database,pathways database PSMA5 USP14 MI:0362 inference MI:0461,MI:1106 interaction database,pathways database PSMB4 USP14 MI:0362 inference MI:0461,MI:1106 interaction database,pathways database PSMB6 USP14 MI:0362 inference MI:0461,MI:1106 interaction database,pathways database PSMB5 USP14 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database HLA-B USP14 MI:0045 experimental interaction detection MI:0461 interaction database CORO1A USP14 MI:0362 inference MI:0461 interaction database GABRA5 USP14 MI:0362 inference MI:0461 interaction database DNAJA1 USP14 MI:0362 inference MI:0461 interaction database GABRA3 USP14 MI:0362 inference MI:0461 interaction database HSPA1L USP14 MI:0362 inference MI:0461 interaction database HSPA4 USP14 MI:0362 inference MI:0461 interaction database PSMC2 USP14 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database PSMB10 USP14 MI:0362 inference MI:1106 pathways database MTOR USP14 MI:0362 inference MI:0461 interaction database HTT USP14 MI:0045 experimental interaction detection MI:0461 interaction database PSMC4 USP14 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database UTRN USP14 MI:0362 inference MI:0461 interaction database CAPZA2 USP14 MI:0362 inference MI:0461 interaction database GABRA2 USP14 MI:0362 inference MI:0461 interaction database GABRA4 USP14 MI:0362 inference MI:0461 interaction database PSMD8 USP14 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database CSNK1D USP14 MI:0362 inference MI:0461 interaction database CCT3 USP14 MI:0362 inference MI:0461 interaction database PSMB3 USP14 MI:0362 inference MI:0461,MI:1106 interaction database,pathways database PSMB2 USP14 MI:0362 inference MI:0461,MI:1106 interaction database,pathways database PSMD7 USP14 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database PRKX USP14 MI:0362 inference MI:0461 interaction database PGD USP14 MI:0362 inference MI:0461 interaction database RAP1GDS1 USP14 MI:0362 inference MI:0461 interaction database CAPZA1 USP14 MI:0362 inference MI:0461 interaction database USP14 PRKAA2 MI:0362 inference MI:0461 interaction database USP14 HSPA2 MI:0362 inference MI:0461 interaction database USP14 RAD23A MI:0045 experimental interaction detection MI:0461 interaction database USP14 RAD23B MI:0362 inference MI:0461 interaction database USP14 PSMD4 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database USP14 SHFM1 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database USP14 PSMA6 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database USP14 CXCR4 MI:0045 experimental interaction detection MI:0461 interaction database USP14 PSME3 MI:0362 inference MI:1106 pathways database USP14 SUMO2 MI:0045 experimental interaction detection MI:0461 interaction database USP14 CALM1 MI:0362 inference MI:0461 interaction database USP14 PSMC1 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database USP14 PSMC5 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database USP14 PSMC6 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database USP14 UBA52 MI:0362 inference MI:0461 interaction database USP14 PPP3R1 MI:0045 experimental interaction detection MI:0461 interaction database USP14 TUBB4B MI:0362 inference MI:0461 interaction database USP14 FANCC MI:0045 experimental interaction detection MI:0461 interaction database USP14 GFPT1 MI:0362 inference MI:0461 interaction database USP14 PSME1 MI:0362 inference MI:1106 pathways database USP14 BCL2L1 MI:0045 experimental interaction detection MI:0461 interaction database USP14 PPP3CA MI:0045 experimental interaction detection MI:0461 interaction database USP14 PSMD2 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database USP14 TUBB3 MI:0362 inference MI:0461 interaction database USP14 TUBB2A MI:0362 inference MI:0461 interaction database USP14 CAMK1 MI:0362 inference MI:0461 interaction database USP14 USP10 MI:0362 inference MI:0461 interaction database USP14 PSME4 MI:0362 inference MI:1106 pathways database USP14 PSMD6 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database USP14 UBE3C MI:0362 inference MI:0461 interaction database USP14 UBE2V2 MI:0045 experimental interaction detection MI:0461 interaction database USP14 ADRM1 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database USP14 PSMD5 MI:0362 inference MI:1106 pathways database USP14 GABRA6 MI:0362 inference MI:0461 interaction database USP14 CAMK4 MI:0362 inference MI:0461 interaction database USP14 TUBB8 MI:0362 inference MI:0461 interaction database USP14 PNCK MI:0362 inference MI:0461 interaction database USP14 CORO6 MI:0362 inference MI:0461 interaction database USP14 CAMK1D MI:0362 inference MI:0461 interaction database USP14 ULK2 MI:0362 inference MI:0461 interaction database USP14 ZDHHC14 MI:0362 inference MI:0461 interaction database USP14 PSMA8 MI:0362 inference MI:0461,MI:1106 interaction database,pathways database USP14 DNAJA4 MI:0362 inference MI:0461 interaction database USP14 PSMF1 MI:0362 inference MI:1106 pathways database USP14 HSPH1 MI:0362 inference MI:0461 interaction database USP14 RQCD1 MI:0362 inference MI:0461 interaction database USP14 CORO2A MI:0362 inference MI:0461 interaction database USP14 RAD50 MI:0362 inference MI:0461 interaction database USP14 COPS5 MI:0045 experimental interaction detection MI:0461 interaction database USP14 USP7 MI:0045 experimental interaction detection MI:0461 interaction database USP14 CAPZA3 MI:0362 inference MI:0461 interaction database USP14 CAMK1G MI:0362 inference MI:0461 interaction database USP14 USP28 MI:0045 experimental interaction detection MI:0461 interaction database USP14 SRPK1 MI:0362 inference MI:0461 interaction database USP14 PSMB7 MI:0362 inference MI:1106 pathways database USP14 PSMD1 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database USP14 RGPD5 MI:0045 experimental interaction detection MI:0461 interaction database USP14 CDC6 MI:0362 inference MI:0461 interaction database USP14 CORO1B MI:0362 inference MI:0461 interaction database USP14 PAAF1 MI:0362 inference MI:0461 interaction database USP14 TUBB6 MI:0362 inference MI:0461 interaction database USP14 TUBB2B MI:0362 inference MI:0461 interaction database USP14 KIFC1 MI:0362 inference MI:0461 interaction database USP14 UNK MI:0045 experimental interaction detection MI:0461 interaction database USP14 TUBB1 MI:0362 inference MI:0461 interaction database USP14 MDN1 MI:0362 inference MI:0461 interaction database USP14 ZDHHC18 MI:0362 inference MI:0461 interaction database USP14 EIF2AK4 MI:0362 inference MI:0461 interaction database USP14 GABBR1 MI:0045 experimental interaction detection MI:0461 interaction database USP14 NXF1 MI:0045 experimental interaction detection MI:0461 interaction database USP14 USP21 MI:0045 experimental interaction detection MI:0461 interaction database USP14 PSME2 MI:0362 inference MI:1106 pathways database USP14 CORO1C MI:0362 inference MI:0461 interaction database USP14 PSMD13 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database USP14 SRPK3 MI:0362 inference MI:0461 interaction database USP14 CORO2B MI:0362 inference MI:0461 interaction database USP14 ZDHHC9 MI:0362 inference MI:0461 interaction database USP14 RNF11 MI:0045 experimental interaction detection MI:0461 interaction database USP14 USP15 MI:0045 experimental interaction detection MI:0461 interaction database USP14 UCHL5 MI:0045 experimental interaction detection MI:0461 interaction database USP14 SRPRB MI:0045 experimental interaction detection MI:0461 interaction database