PTM - CPLM Gene Name UniProt ID Type Position Code XIAP; API3; BIRC4; IAP3 P98170 Ubiquitination 328 K XIAP; API3; BIRC4; IAP3 P98170 Ubiquitination 322 K XIAP; API3; BIRC4; IAP3 P98170 Ubiquitination 10 K XIAP; API3; BIRC4; IAP3 P98170 Ubiquitination 31 K XIAP; API3; BIRC4; IAP3 P98170 Ubiquitination 168 K XIAP; API3; BIRC4; IAP3 P98170 Ubiquitination 208 K XIAP; API3; BIRC4; IAP3 P98170 Ubiquitination 297 K XIAP; API3; BIRC4; IAP3 P98170 Ubiquitination 311 K XIAP; API3; BIRC4; IAP3 P98170 Ubiquitination 206 K XIAP; API3; BIRC4; IAP3 P98170 Ubiquitination 480 K XIAP; API3; BIRC4; IAP3 P98170 Ubiquitination 448 K XIAP; API3; BIRC4; IAP3 P98170 Ubiquitination 19 K XIAP; API3; BIRC4; IAP3 P98170 Ubiquitination 358 K XIAP; API3; BIRC4; IAP3 P98170 Ubiquitination 334 K XIAP; API3; BIRC4; IAP3 P98170 Ubiquitination 116 K XIAP; API3; BIRC4; IAP3 P98170 Ubiquitination 433 K

PTM - dbPAF Gene Name UniProt ID Position Type Species XIAP; API3; BIRC4; IAP3 P98170 120 Y Homo sapiens(Human) XIAP; API3; BIRC4; IAP3 P98170 123 S Homo sapiens(Human) XIAP; API3; BIRC4; IAP3 P98170 139 Y Homo sapiens(Human) XIAP; API3; BIRC4; IAP3 P98170 180 T Homo sapiens(Human) XIAP; API3; BIRC4; IAP3 P98170 32 T Homo sapiens(Human) XIAP; API3; BIRC4; IAP3 P98170 355 T Homo sapiens(Human) XIAP; API3; BIRC4; IAP3 P98170 356 T Homo sapiens(Human) XIAP; API3; BIRC4; IAP3 P98170 359 T Homo sapiens(Human) XIAP; API3; BIRC4; IAP3 P98170 361 S Homo sapiens(Human) XIAP; API3; BIRC4; IAP3 P98170 40 S Homo sapiens(Human) XIAP; API3; BIRC4; IAP3 P98170 400 S Homo sapiens(Human) XIAP; API3; BIRC4; IAP3 P98170 402 S Homo sapiens(Human) XIAP; API3; BIRC4; IAP3 P98170 404 Y Homo sapiens(Human) XIAP; API3; BIRC4; IAP3 P98170 406 S Homo sapiens(Human) XIAP; API3; BIRC4; IAP3 P98170 427 S Homo sapiens(Human) XIAP; API3; BIRC4; IAP3 P98170 429 T Homo sapiens(Human) XIAP; API3; BIRC4; IAP3 P98170 43 S Homo sapiens(Human) XIAP; API3; BIRC4; IAP3 P98170 430 S Homo sapiens(Human) XIAP; API3; BIRC4; IAP3 P98170 436 S Homo sapiens(Human) XIAP; API3; BIRC4; IAP3 P98170 45 S Homo sapiens(Human) XIAP; API3; BIRC4; IAP3 P98170 46 T Homo sapiens(Human) XIAP; API3; BIRC4; IAP3 P98170 470 T Homo sapiens(Human) XIAP; API3; BIRC4; IAP3 P98170 5 S Homo sapiens(Human) XIAP; API3; BIRC4; IAP3 P98170 87 S Homo sapiens(Human)

PTM - PhosSNP Gene Name dbSNP ID Gene Mutation AA Mutation Mutation Position Code Peptide Score Modification Type XIAP; API3; BIRC4; IAP3 rs28382722 TCT->TTT S->F 139 Y PSETHADYLLRTGQV 139 Phosphorylation TypeIII-

PTM - PhosphositePlus UniProt ID MOD_RSD Type SITE_+/-7_AA P98170 R131-m1 Methylation RDHFALDrPSETHAD P98170 R248-m1 Methylation SDAVSSDrNFPNSTN P98170 S5-p Phosphorylation ___MTFNsFEGSkTC P98170 T32-p Phosphorylation EEFNRLktFANFPSG P98170 S40-p Phosphorylation FANFPSGsPVSAstL P98170 S45-p Phosphorylation SGsPVSAstLARAGF P98170 T46-p Phosphorylation GsPVSAstLARAGFL P98170 S87-p Phosphorylation VGRHRKVsPNCRFIN P98170 Y120-p Phosphorylation GQYkVENyLGsRDHF P98170 S123-p Phosphorylation kVENyLGsRDHFALD P98170 Y139-p Phosphorylation PSETHADyLLRTGQV P98170 T180-p Phosphorylation WPDYAHLtPRELASA P98170 S218-p Phosphorylation EPCDRAWsEHRRHFP P98170 S347-p Phosphorylation NNIHLTHsLEECLVR P98170 S361-p Phosphorylation RTTEkTPsLTRRIDD P98170 S400-p Phosphorylation MEEKIQIsGsNyksL P98170 S402-p Phosphorylation EKIQIsGsNyksLEV P98170 Y404-p Phosphorylation IQIsGsNyksLEVLV P98170 S406-p Phosphorylation IsGsNyksLEVLVAD P98170 T429-p Phosphorylation MQDESSQtsLQkEIs P98170 S430-p Phosphorylation QDESSQtsLQkEIst P98170 S436-p Phosphorylation tsLQkEIstEEQLRR P98170 T437-p Phosphorylation sLQkEIstEEQLRRL P98170 K405-sm Sumoylation QIsGsNyksLEVLVA P98170 K10-ub Ubiquitination FNsFEGSkTCVPADI P98170 K31-ub Ubiquitination VEEFNRLktFANFPS P98170 K116-ub Ubiquitination GIQNGQYkVENyLGs P98170 K168-ub Ubiquitination YSEEARLkSFQNWPD P98170 K208-ub Ubiquitination FCCGGKLkNWEPCDR P98170 K322-ub Ubiquitination DPWEQHAkWYPGCkY P98170 K328-ub Ubiquitination AkWYPGCkYLLEQKG P98170 K358-ub Ubiquitination CLVRTTEkTPsLTRR P98170 K405-ub Ubiquitination QIsGsNyksLEVLVA P98170 K433-ub Ubiquitination SSQtsLQkEIstEEQ

PTM - dbPTM UniProt ID Position Code Type Resources References P98170 87 S Phosphorylation Swiss-Prot 1010711 14645242;17698078 P98170 139 Y Phosphorylation Swiss-Prot 1010711 17053785 P98170 322 K Ubiquitylation Swiss-Prot 1010711 12747801 P98170 328 K Ubiquitylation Swiss-Prot 1010711 12747801 P98170 450 C S-nitrosylation Swiss-Prot 1010711 20670888 P98170 40 S Phosphorylation PhosphoELM.10011 18669648 P98170 87 S Phosphorylation PhosphoELM.10011 14645242;14645242 P98170 10 K Ubiquitylation Phosphositeplus.1010730 21890473 P98170 116 K Ubiquitylation Phosphositeplus.1010730 21890473 P98170 168 K Ubiquitylation Phosphositeplus.1010730 20972266;21890473;21906983 P98170 31 K Ubiquitylation Phosphositeplus.1010730 20972266;21890473;21906983 P98170 322 K Ubiquitylation Phosphositeplus.1010730 22072751 P98170 328 K Ubiquitylation Phosphositeplus.1010730 21890473;22072751 P98170 358 K Ubiquitylation Phosphositeplus.1010730 20972266 P98170 433 K Ubiquitylation Phosphositeplus.1010730 21906983 P98170 123 S Phosphorylation Phosphositeplus.1010730 22322096 P98170 430 S Phosphorylation Phosphositeplus.1010730 22072751 P98170 87 S Phosphorylation Phosphositeplus.1010730 14645242;17537996 P98170 139 Y Phosphorylation Phosphositeplus.1010730 17053785 P98170 40 S Phosphorylation HPRD 9.0 18669648,20068231 P98170 436 S Phosphorylation HPRD 9.0 20068231 P98170 355 T Phosphorylation HPRD 9.0 20068231 P98170 356 T Phosphorylation HPRD 9.0 20068231 P98170 470 T Phosphorylation HPRD 9.0 18452278 P98170 87 S Phosphorylation (AKT1) HPRD 9.0 14645242 P98170 87 S Phosphorylation (AKT2) HPRD 9.0 14645242 P98170 12 C S-nitrosylation dbSNO 1.0 19273858 P98170 90 C S-nitrosylation dbSNO 1.0 19273858 P98170 213 C S-nitrosylation dbSNO 1.0 19273858 P98170 300 C S-nitrosylation dbSNO 1.0 19273858 P98170 303 C S-nitrosylation dbSNO 1.0 19273858 P98170 327 C S-nitrosylation dbSNO 1.0 19273858 P98170 351 C S-nitrosylation dbSNO 1.0 19273858 P98170 322 K Ubiquitylation UbiProtDB 1.0 12747801;10797013 P98170 328 K Ubiquitylation UbiProtDB 1.0 12747801;10797013

PTM - HPRD Symbol Position Code Type References XIAP 355 T Phosphorylation 20068231 XIAP 356 T Phosphorylation 20068231 XIAP 40 S Phosphorylation 18669648,20068231 XIAP 436 S Phosphorylation 20068231 XIAP 470 T Phosphorylation 18452278 XIAP 87 S Phosphorylation 14645242

PTM - Phospho.ELM UniProt Position Code PMIDs Kinase Source Type P98170 40 S 18669648 HTP Phosphorylation P98170 87 S 14645242 PKB_group LTP Phosphorylation P98170 87 S 14645242 PKB_beta LTP Phosphorylation

PTM - UniProt UniProt ID Position Type PMIDs P98170 87 Phosphoserine; by PKB 14645242;17698078 P98170 450 S-nitrosocysteine 20670888

PTM - BioGRID Entrez Gene BioGRID ID Position Code Type PMIDs 331 106828 - K Ubiquitination 14645242 331 106828 - K Ubiquitination 14523016 331 106828 - K Ubiquitination 12525502 331 106828 - K Ubiquitination 20171186 331 106828 - K Ubiquitination 21185211 331 106828 - K Ubiquitination 20972266 331 106828 - K Ubiquitination 21139048 331 106828 - K Ubiquitination 21890473 331 106828 - K Ubiquitination 21906983 331 106828 - K Ubiquitination 15078891 331 106828 - K Ubiquitination 22584050 331 106828 - K Neddylation 22584050 331 106828 - K Ubiquitination 22072751 331 106828 - K Ubiquitination 21255191 331 106828 - K Ubiquitination 19273858 331 106828 - K Ubiquitination 22505724 331 106828 - K Ubiquitination 17318174 331 106828 - K Ubiquitination 21963094 331 106828 - K Ubiquitination 23000965 331 106828 - K Ubiquitination 23818254 331 106828 - K Ubiquitination 23833193 331 106828 - K Ubiquitination 23906794 331 106828 - K Ubiquitination 19782107 331 106828 - K Ubiquitination 24305822 331 106828 - K Neddylation 21145488

PTM - mUbiSiDa Gene Name Species Ubiquitination Site Ubiquitination Sequence Evidence PMID XIAP Homo sapiens (Human) 168; 10; 31; 328 "168,SEEARLKSFQNWP; 10,NSFEGSKTCVPAD; 31,EEFNRLKTFANFP; 328,KWYPGCKYLLEQK" 168:21890473; 10:21890473; 31:21890473; 328:21890473 XIAP Homo sapiens (Human) 10; 31 "10,NSFEGSKTCVPAD; 31,EEFNRLKTFANFP" 10:21890473; 31:21890473