PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus NTRK1 WDR59 25921289 biogrid exp P P P G P P P P P P P P P P P P P P WDR59 TXNDC5 26186194 biogrid exp P P P P P P P WDR59 GATSL3 26186194 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G EP300 WDR59 21988832 biogrid,intact exp GP GP G G G GP G G GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP G GP GP G CHM WDR59 19615732 intact exp GP GP G G G GP G G GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP G GP GP G HERC2 WDR59 25476789 biogrid exp GP GP G G G GP G G GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP G GP GP G RAE1 WDR59 19615732 biogrid exp GP GP G G G GP G G GP G GP G GP GP G GP GP GP GP G GP G G GP GP G GP GP G WDR5 WDR59 17041588 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G WDR59 THTPA 26186194 biogrid exp GP GP G G G GP G G GP G GP P GP GP G GP GP GP GP G GP GP GP GP GP G GP GP G WDR59 OLFM4 26186194 biogrid exp G G G G G G G G G G SEC13 WDR59 26186194 biogrid exp, ortho GP GP G G G GP G G GP G G G G G G GP GP G GP G GP GP GP G GP G GP G G WDR59 SEH1L 26496610 biogrid,intact exp, ortho G GP G G G GP G G GP G G G GP G G GP GP G GP G GP GP G G GP G GP GP G ATP6V1B2 WDR59 ortho G GP G G G GP G G GP G GP GP GP GP G GP GP G GP G GP GP GP G GP G GP GP G GART WDR59 ortho GP GP G G G GP G G GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP G GP GP G VCP WDR59 ortho GP GP G G G GP G G GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP G GP GP G PFKL WDR59 ortho GP G G G G GP G G GP G GP GP G G G GP GP G G G GP G GP G GP G GP GP G CLTC WDR59 ortho GP GP G G G GP G G GP G GP GP GP GP G GP GP G GP G GP GP GP G GP G GP GP G WDR59 NOP58 ortho GP GP G G G GP G G GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP G GP GP G GFPT2 WDR59 ortho GP GP G G G GP G G GP G GP GP GP GP G GP GP GP GP G GP GP GP G GP G GP GP G ACTG1 WDR59 ortho GP GP G G G GP G G GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP G GP GP G CCT6A WDR59 ortho GP GP G G G GP G G GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP G GP GP G OTC WDR59 ortho P GP GP GP HSPA9 WDR59 ortho GP GP G G G GP G G GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP G GP GP G HSPD1 WDR59 ortho GP GP G G G GP G G GP G GP GP GP GP G GP GP GP GP G GP GP GP G GP G GP GP G PFKP WDR59 ortho GP GP G G G GP G G GP G GP P GP GP G GP GP GP GP G GP GP GP GP GP G GP GP G GALT WDR59 ortho GP GP G G G GP G G GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP G GP GP G WDR59 NPRL2 ortho GP GP G G G GP G G GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP G GP GP G CAD WDR59 ortho GP GP G G G GP G G GP G GP GP GP GP G GP GP GP GP G GP GP G P GP G GP GP G ATP6V1A WDR59 ortho G GP G G G GP G G GP G GP G GP GP G GP GP GP GP G GP GP GP GP GP G GP GP G PRKAA2 WDR59 ortho G GP G GP G G GP G GP GP G G GP GP GP GP G G GP GP GP G GP GP G PGAM2 WDR59 ortho P G P P P GP G GP CCT8 WDR59 ortho GP GP G G G GP G G GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP G GP GP G PPID WDR59 ortho G GP G G G GP G G GP G GP GP GP GP G GP GP GP GP G GP GP G GP GP G GP GP G ALDH1A2 WDR59 ortho GP GP G GP G G GP GP GP GP GP G GP GP GP GP G GP GP GP GP GP G GP GP G WDR59 PRMT1 ortho GP GP G G G GP G G GP G GP G GP GP G GP GP G G G GP GP GP GP GP G GP GP G WDR59 DNAJA3 ortho GP GP G G G GP G G GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP G GP GP G ATP5A1 WDR59 ortho GP GP G G G GP G G GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP G GP GP G ALDH1B1 WDR59 ortho GP P G G GP G G GP GP GP P P GP GP GP GP G P GP GP GP GP GP GP G COPB1 WDR59 ortho GP GP G G G GP G G GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP G GP GP G ATP5B WDR59 ortho GP GP G G G GP G G GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP G GP GP G PSMC4 WDR59 ortho GP GP G G G GP G G GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP G GP GP G UBE2G2 WDR59 25402006 ortho, pred GP GP G G G GP G G GP G GP GP GP GP G GP GP G GP G GP GP G G GP G GP GP G LRMP WDR59 21836163 pred G G G G GP G G G G GP GP G G GP GP GP G GP G G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q6PJI9 P0CG48 affinity chromatography technology 22505724 physical association X 2 Q6PJI9 P61964 affinity chromatography technology 17041588 physical association X 2 Q6PJI9 P0CG48 affinity chromatography technology 21139048 physical association X 2 Q6PJI9 P0CG48 affinity chromatography technology 21906983 physical association X 2 Q09472 Q6PJI9 two hybrid 21988832 direct interaction X 2 Q6PJI9 P78406 affinity chromatography technology 19615732 physical association X 2 Q6PJI9 anti tag coimmunoprecipitation 19615732 physical association C 47 Q6PJI9 Q7CKZ2 two hybrid pooling approach 20711500 physical association X 2 Q6PJI9 Q81TL7 two hybrid pooling approach 20711500 physical association X 2 Q6PJI9 Q81L99 two hybrid pooling approach 20711500 physical association X 2 Q6PJI9 Q8CKJ5 two hybrid pooling approach 20711500 physical association X 2

PPI - HINT Gene A Gene B PMID Method Quality CHM WDR59 19615732 0007 HT SEC13 WDR59 26186194 0004 HT RAE1 WDR59 19615732 0004 HT WDR59 OLFM4 26186194 0004 HT WDR59 TXNDC5 26186194 0004 HT WDR59 GATSL3 26186194,26972053 0004,0004 HT,LC WDR59 SEH1L 26496610,26496610 0007,0004 HT WDR59 THTPA 26186194 0004 HT CHM WDR59 19615732 0007 HT SEC13 WDR59 26186194 0004 HT RAE1 WDR59 19615732 0004 HT WDR59 OLFM4 26186194 0004 HT WDR59 TXNDC5 26186194 0004 HT WDR59 GATSL3 26186194 0004 HT WDR59 SEH1L 26496610,26496610 0007,0004 HT WDR59 THTPA 26186194 0004 HT WDR59 GATSL3 26972053 0004 LC EP300 WDR59 21988832 0018 HT

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q6PJI9 Q09472 WDR59 EP300 0.183 21988832 Q6PJI9 P24386 WDR59 CHM 0.126 19615732 Q8CKJ5 Q6PJI9 Q8CKJ5 WDR59 0.126 20711500 Q8NBS9 Q6PJI9 TXNDC5 WDR59 0.126 26186194 Q9H6Z9 Q6PJI9 EGLN3 WDR59 0.126 26972000 Q6PJI9 A6NHX0 WDR59 GATSL2 0.21 26972053 Q6PJI9 P58004 WDR59 SESN2 0.21 26972053 Q6PJI9 P61964 WDR59 WDR5 0.126 17041588 Q81L99 Q6PJI9 Q81L99 WDR59 0.126 20711500 Q81TL7 Q6PJI9 TRPA WDR59 0.126 20711500 Q9NXC5 Q6PJI9 MIOS WDR59 0.21 26972053 Q6UX06 Q6PJI9 OLFM4 WDR59 0.126 26186194 Q7CKZ2 Q6PJI9 RHO WDR59 0.126 20711500 Q6PJI9 P04629 WDR59 NTRK1 0.126 25921289 Q6PJI9 O95714 WDR59 HERC2 0.126 25476789 Q96EE3 Q6PJI9 SEH1L WDR59 0.236 26496610 Q6PJI9 P58043 WDR59 SESN2 0.236 26496610 Q8WTW4 Q6PJI9 NPRL2 WDR59 0.21 23723238 Q8WTX7 Q6PJI9 GATSL3 WDR59 0.309 26972053,26186194 Q9BU02 Q6PJI9 THTPA WDR59 0.126 26186194 Q96S15 Q6PJI9 WDR24 WDR59 0.21 23723238 Q9UNN5 Q6PJI9 FAF1 WDR59 0.126 26389662 Q6PJI9 P78406 WDR59 RAE1 0.126 19615732 Q6PJI9 P55735 WDR59 SEC13 0.126 26186194

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 HERC2 WDR59 MI:0045 experimental interaction detection MI:0461 interaction database NTRK1 WDR59 MI:0045 experimental interaction detection MI:0461 interaction database UBC WDR59 MI:0045 experimental interaction detection MI:0461 interaction database CHM WDR59 MI:0045 experimental interaction detection MI:0461 interaction database SEC13 WDR59 MI:0045 experimental interaction detection MI:0461 interaction database SESN2 WDR59 MI:0362 inference MI:0461 interaction database SESN3 WDR59 MI:0362 inference MI:0461 interaction database WDR5 WDR59 MI:0045 experimental interaction detection MI:0461 interaction database RAE1 WDR59 MI:0045 experimental interaction detection MI:0461 interaction database EP300 WDR59 MI:0045 experimental interaction detection MI:0461 interaction database WDR59 OLFM4 MI:0045 experimental interaction detection MI:0461 interaction database WDR59 TXNDC5 MI:0045 experimental interaction detection MI:0461 interaction database WDR59 NPRL2 MI:0045 experimental interaction detection MI:0461 interaction database WDR59 GATSL3 MI:0045 experimental interaction detection MI:0461 interaction database WDR59 SEH1L MI:0045 experimental interaction detection MI:0461 interaction database WDR59 WDR24 MI:0045 experimental interaction detection MI:0461 interaction database WDR59 THTPA MI:0045 experimental interaction detection MI:0461 interaction database WDR59 FAF1 MI:0045 experimental interaction detection MI:0461 interaction database WDR59 SESN1 MI:0362 inference MI:0461 interaction database