PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus RP2 DMXL2 26186194 biogrid exp GP G GP P GP P P GP P G GP P P GP GP GP G GP DMXL2 AKTIP 23414517 intact exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP P GP G GP GP G DMXL2 ROGDI 26186194 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP G GP G GP GP G DMXL2 FAF2 26186194 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G GLUL DMXL2 26186194 biogrid exp GP G G G GP GP G G GP G G GP GP G G GP GP G G G GP G G GP G GP GP G DMXL2 ANTXR1 26186194 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G DMXL2 C1QTNF2 26186194 biogrid exp P P GP GP P P P GP P P P P P P GP GP P G DMXL2 WDR7 12786944, 21836163 biogrid exp, ortho, pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP P GP G GP GP G RAB3GAP1 DMXL2 12786944, 21836163 biogrid exp, pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP P GP G GP GP G RAB3A DMXL2 11809763, 21836163 hprd exp, pred GP G G G GP G G G G G G G GP G GP G G G G G G PRKCG DMXL2 ortho G G G G G GP G G G G G G G GP G G G G G G G YWHAE DMXL2 ortho GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP P GP G GP GP G PFKP DMXL2 ortho GP GP G G GP GP G GP GP G GP P GP GP G GP GP G GP G GP GP GP P GP G GP GP G DYNC1H1 DMXL2 ortho GP GP G G GP GP G GP GP G GP G GP GP G GP GP G GP G GP G GP P GP G GP GP G DMXL2 NCKAP1 ortho GP GP G G G GP G GP GP G GP G G GP G GP GP G GP G GP GP G GP G GP GP G ATP6V1A DMXL2 ortho G GP G G GP GP G GP GP G GP G GP GP G GP GP G GP G GP GP GP P GP G GP GP G DMXL2 ADAM19 ortho G G G G G GP G G G G GP GP G G G G GP G GP G G G G G G GP GP G IDH3G DMXL2 ortho GP GP G G GP GP G GP GP G GP G GP GP G GP GP G GP G GP GP GP P GP G GP GP G PAX6 DMXL2 ortho G GP P G P GP GP GP G P GP GP GP NF2 DMXL2 ortho GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP P GP G GP GP G NTN1 DMXL2 ortho GP GP G P GP G GP GP G P G GP G G GP GP G GP G GP G GP GP GP GP G ATP6V1C1 DMXL2 ortho G GP G G G GP G GP GP G GP G GP GP G GP GP G GP G GP GP GP GP G GP G G DMXL2 CYFIP2 ortho GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP P GP G GP GP G PPP5C DMXL2 ortho GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP P GP G GP GP G MATR3 DMXL2 ortho GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G P GP GP P GP G GP P YWHAZ DMXL2 ortho GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP P GP G GP GP G PFKL DMXL2 ortho GP G G G GP GP G G GP G GP GP G G G GP GP G G G GP G GP GP G GP GP G DMXL2 VAT1 21836163 pred GP GP G G GP GP G G GP G GP GP GP G G GP GP G GP G G GP GP GP G GP GP G RGS6 DMXL2 21836163 pred P P G P GP GP P P P P P P GP P P P P P P P P DMXL2 SEC31B 21836163 pred P GP G GP GP G GP G GP GP P GP GP GP P G P P P P G GP GP SYT6 DMXL2 21836163 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP P GP GP GP G NAPA DMXL2 21836163 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP P GP G GP GP G RGS9 DMXL2 23023127 pred G G G G G G G G DMXL2 DNM3 21836163 pred G G G G G G G G G G G G G G G G G G G G G RAC2 DMXL2 21836163 pred G GP G G GP GP G GP G G G G GP GP G G GP G G G G GP G P G G G GP G YKT6 DMXL2 21836163 pred GP P G P GP G GP GP G GP P GP P G GP GP G P G GP GP GP P GP G GP GP DMXL2 SYN2 21836163 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G DMXL2 MADD 21836163 pred GP GP G G GP GP G G GP G GP GP GP GP G GP GP G GP G GP GP GP P GP G GP GP G SLC17A8 DMXL2 21836163 pred CPLX2 DMXL2 21836163 pred G G G G G G G SNAPIN DMXL2 21836163 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP P GP G GP GP G VAMP1 DMXL2 21836163 pred G GP G G G GP G G GP G GP GP GP GP G GP GP G GP G GP GP GP P GP G GP GP G SYN3 DMXL2 21836163 pred P G GP G P P G P P P P GP P P P P UNC13B DMXL2 21836163 pred G GP G G GP GP G G GP G GP GP GP GP G GP GP G GP G GP GP G GP G GP GP G APBA3 DMXL2 21836163 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP G GP P GP G GP GP G DOC2A DMXL2 21836163 pred G G G G G G G G DMXL2 NAPG 21836163 pred G GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP G P GP G GP GP G CSNK1G2 DMXL2 21836163 pred G G G G G G G G GP G G G G G G GP G G GP G G G G GP G GP G G DMXL2 SLC17A7 21836163 pred G G G G GP G G G G G GP G G G G G DMXL2 RPH3A 21836163 pred G G G G G GP G G G G G G GP G G G GP G G G G G G G G G SV2A DMXL2 21836163 pred G G G G GP G GP G G G GP P G G G G SNAP29 DMXL2 21836163 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP P GP G GP GP G TMEM163 DMXL2 21836163 pred G G G GP G G P G GP G G G GP G G G P GP P G G GP GP DMXL2 SYT11 21836163 pred GP GP G G G GP G G GP G GP G G G G GP GP G G G G G GP G G G G

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B DMXL2 AKTIP MI:0663(confocal microscopy) 23414517 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (intact) UniProt_126771 prey bait RAB3GAP1 DMXL2 MI:0004(affinity chromatography technology) 12786944 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_89187 bait prey DMXL2 WDR7 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 12786944 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_89185|BIOGRID_89184 bait|prey prey|bait NRF1 DMXL2 MI:0428(imaging technique) 24250222 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_295732 bait prey UBC DMXL2 MI:0004(affinity chromatography technology) 21139048 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_167890 bait prey RAB3A DMXL2 MI:0493(in vivo) 11809763 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) - MI:0468(hprd) HPRD_2314 - -

PPI - HINT Gene A Gene B PMID Method Quality RP2 DMXL2 26186194 0004 HT GLUL DMXL2 26186194 0004 HT DMXL2 FAF2 26186194 0004 HT DMXL2 C1QTNF2 26186194 0004 HT DMXL2 ROGDI 26186194 0004 HT DMXL2 ANTXR1 26186194 0004 HT RP2 DMXL2 26186194 0004 HT GLUL DMXL2 26186194 0004 HT DMXL2 FAF2 26186194 0004 HT DMXL2 C1QTNF2 26186194 0004 HT DMXL2 ROGDI 26186194 0004 HT DMXL2 ANTXR1 26186194 0004 HT MTNR1B DMXL2 26514267 0018 LC DMXL2 AKTIP 23414517 0399 HT

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q9GZN7 Q8TDJ6 ROGDI DMXL2 0.126 26186194 Q9H8T0 Q8TDJ6 AKTIP DMXL2 0.126 23414517 Q9Y4E6 Q8TDJ6 WDR7 DMXL2 0.376 12786944 Q9H6X2 Q8TDJ6 ANTXR1 DMXL2 0.126 26186194 Q8TDJ6 O75695 DMXL2 RP2 0.126 26186194 Q96CS3 Q8TDJ6 FAF2 DMXL2 0.126 26186194 Q9BXJ5 Q8TDJ6 C1QTNF2 DMXL2 0.126 26186194 Q8TDJ6 P49286 DMXL2 MTNR1B 0.183 26514267 Q8TDJ6 Q15042 DMXL2 RAB3GAP1 0.21 12786944 Q8TDJ6 P15104 DMXL2 GLUL 0.126 26186194

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 NTN3 DMXL2 MI:0362 inference MI:0461 interaction database EIF4EBP3 DMXL2 MI:0362 inference MI:0461 interaction database RP2 DMXL2 MI:0045 experimental interaction detection MI:0461 interaction database NTN1 DMXL2 MI:0362 inference MI:0461 interaction database RAB3D DMXL2 MI:0362 inference MI:0461 interaction database PRKCG DMXL2 MI:0362 inference MI:0461 interaction database PFKM DMXL2 MI:0362 inference MI:0461 interaction database UBC DMXL2 MI:0045 experimental interaction detection MI:0461 interaction database GLUL DMXL2 MI:0045 experimental interaction detection MI:0461 interaction database PFKL DMXL2 MI:0362 inference MI:0461 interaction database ATP6V1C1 DMXL2 MI:0362 inference MI:0461 interaction database PAX6 DMXL2 MI:0362 inference MI:0461 interaction database YWHAQ DMXL2 MI:0362 inference MI:0461 interaction database YWHAB DMXL2 MI:0362 inference MI:0461 interaction database NF2 DMXL2 MI:0362 inference MI:0461 interaction database ATP6V1A DMXL2 MI:0362 inference MI:0461 interaction database MATR3 DMXL2 MI:0362 inference MI:0461 interaction database MTNR1B DMXL2 MI:0045 experimental interaction detection MI:0461 interaction database IDH3G DMXL2 MI:0362 inference MI:0461 interaction database PPP5C DMXL2 MI:0362 inference MI:0461 interaction database NCKAP1L DMXL2 MI:0362 inference MI:0461 interaction database YWHAZ DMXL2 MI:0362 inference MI:0461 interaction database PFKP DMXL2 MI:0362 inference MI:0461 interaction database EIF4EBP1 DMXL2 MI:0362 inference MI:0461 interaction database EIF4EBP2 DMXL2 MI:0362 inference MI:0461 interaction database DYNC1H1 DMXL2 MI:0362 inference MI:0461 interaction database RAB3GAP1 DMXL2 MI:0045 experimental interaction detection MI:0461 interaction database ATP6V1C2 DMXL2 MI:0362 inference MI:0461 interaction database DMXL2 FAF2 MI:0045 experimental interaction detection MI:0461 interaction database DMXL2 CYFIP2 MI:0362 inference MI:0461 interaction database DMXL2 C1QTNF2 MI:0045 experimental interaction detection MI:0461 interaction database DMXL2 ROGDI MI:0045 experimental interaction detection MI:0461 interaction database DMXL2 ADAM19 MI:0362 inference MI:0461 interaction database DMXL2 ANTXR1 MI:0045 experimental interaction detection MI:0461 interaction database DMXL2 AKTIP MI:0045 experimental interaction detection MI:0461 interaction database DMXL2 NCKAP1 MI:0362 inference MI:0461 interaction database DMXL2 WDR7 MI:0045 experimental interaction detection MI:0461 interaction database