DNA & RNA Element - microRNA Mirbase Acc miRNA Name Gene ID Gene Symbol miRNA Alignment Alignment Gene Alignment miRNA Start miRNA End Gene Start Gene End Genome Coordinates Conservation Align Score Seed Cat Energy mirSVR Score MIMAT0005956 hsa-miR-1324 148066 ZNRF4 cuUUCACG-UA--UCUU---AAGA-CAGACc ::|||| || :||| |||| ||||| ggGGGUGCAAUGAGGAAUGUUUCUGGUCUGa 2 23 18 48 [hg19:19:5456810-5456840:+] 0.5188 123 0 -23.06 -1.0581 MIMAT0016850 hsa-miR-4301 148066 ZNRF4 aguguucacuucaUCACCCu |||||| cugaaaagaauaaAGUGGGu 2 8 45 64 [hg19:19:5456837-5456856:+] 0.5188 120 6 -11.87 -0.1633 MIMAT0016866 hsa-miR-4315 148066 ZNRF4 cagGUCGAGUCUUUCGCc ::| |: ||||||| aagUGGGUUUGAAAGCGg 2 16 57 74 [hg19:19:5456849-5456866:+] 0.5188 147 7 -18.05 -1.0578 MIMAT0000081 hsa-miR-25 148066 ZNRF4 agucuggCUCUGUUCACGUUAc |||: ::||||||| gggcaggGAGGGGGGUGCAAUg 2 16 8 29 [hg19:19:5456800-5456821:+] 0.5188 155 7 -26.78 -0.1284 MIMAT0000090 hsa-miR-32 148066 ZNRF4 acguugaaUCAUUACACGUUAu || :: ||||||| gggcagggAGGGGGGUGCAAUg 2 15 8 29 [hg19:19:5456800-5456821:+] 0.5188 146 7 -17.58 -0.1309 MIMAT0000092 hsa-miR-92a 148066 ZNRF4 ugUCCGGCCCU--GUUCACGUUAu :||| |||| ::||||||| uaGGGCAGGGAGGGGGGUGCAAUg 2 21 6 29 [hg19:19:5456798-5456821:+] 0.5188 159 7 -26.67 -0.1284 MIMAT0000707 hsa-miR-363 148066 ZNRF4 auGUCUACCUAUGGCACGUUAa |||: | : : ||||||| ggCAGG-GAGGGGGGUGCAAUg 2 21 9 29 [hg19:19:5456801-5456821:+] 0.5188 142 7 -18.44 -0.1271 MIMAT0000719 hsa-miR-367 148066 ZNRF4 agugguaacgaUUUCACGUUAa :::||||||| gggcagggaggGGGGUGCAAUg 2 12 8 29 [hg19:19:5456800-5456821:+] 0.5188 143 7 -15.11 -0.1322 MIMAT0002816 hsa-miR-494 148066 ZNRF4 cuccaaagggcaCAUACAAAGu | ||||||| gggugcaaugagGAAUGUUUCu 2 11 20 41 [hg19:19:5456812-5456833:+] 0.5188 142 7 -13.28 -0.2035 MIMAT0003218 hsa-miR-92b 148066 ZNRF4 ccUCCGGCCCU--GCUCACGUUAu :||| |||| |:||||||| uaGGGCAGGGAGGGGGGUGCAAUg 2 21 6 29 [hg19:19:5456798-5456821:+] 0.5188 163 7 -26.88 -0.1284 MIMAT0004954 hsa-miR-543 148066 ZNRF4 uuCUUCACGUGGC-GCUUACAAa |::||||| :| ||||||| ggGGGGUGCAAUGAGGAAUGUUu 2 21 17 39 [hg19:19:5456809-5456831:+] 0.5188 163 7 -23.35 -0.1287

DNA & RNA Element - TRANSFAC Accession AS Description Species Entrez Pubmed Binding Info G050070 ZNRF4 Homo sapiens 148066

DNA & RNA Element - TargetScan Gene Name UTR Region Start UTR Region End AIR Total Normalized 3P-seq-tags & Pseudocounts Strand hg19_chromosome Genome Start Genome End ZNRF4; RNF204 1 75 100 5.01 + chr19 5456792 5456867

DNA & RNA Element - RepTar Gene Name miRNA Begin End Profile ZNRF4 hsa-miR-1179 beg:22 end:40 pic:3' GGTTGGTTACTTTCTTACGAA 5'& ||||| |.|||||.|| &5' -----CAATG-AGGAATGTTT 3' ZNRF4 hsa-miR-1238 beg:5 end:34 pic:3' CCCCGTCTGTC---------TGCTCCTTC 5'& ||||||. || |.|||||| &5' -GGGCAGGGAGGGGGGTGCAATGAGGAA- 3' ZNRF4 hsa-miR-1281 beg:5 end:25 pic:3' CCC-TCTCCTCCTCCGCT 5'& ||| ||.| ||.||.| &5' GGGCAGGGAGGGGGGTG- 3' ZNRF4 hsa-miR-25 beg:8 end:30 pic:3' AGTCTGGCTCTGTTCACGTTAC 5'& |||. |||. ..|||||||| &5' -CAGG--GAGGGGGGTGCAATG 3' ZNRF4 hsa-miR-30estar beg:32 end:51 pic:3' CGACATTTGTAGGCT-GACTTTC 5'& ||| ||.|. |||||| &5' --TGTT----TCTGGTCTGAAA- 3' ZNRF4 hsa-miR-32 beg:7 end:30 pic:3' ACGTTGAATCATTACACGTTAT 5'& |||. || |||||||. &5' -GCAGGG-AGGGGGGTGCAATG 3' ZNRF4 hsa-miR-324-5p beg:7 end:26 pic:3' TGTGGTTACGGGA--TCCCCTACGC 5'& || .||||.||| &5' --------GCAGGGAGGGGGGTGC- 3' ZNRF4 hsa-miR-326 beg:11 end:33 pic:3' GACCTCCTTCC-CGGGTCTCC 5'& |||||..|| || |||| &5' --GGAGGGGGGTGCAATGAGG 3' ZNRF4 hsa-miR-363 beg:7 end:29 pic:3' ATGTCTA--CCTATGGCACGTTAA 5'& .|||. ||. ||||||| &5' -GCAGGGAGGGGG---GTGCAAT- 3' ZNRF4 hsa-miR-367 beg:8 end:29 pic:3' AGTGGTAACGA-TTTCACGTTAA 5'& || | ...||||||| &5' ----CAGGGAGGGGGGTGCAAT- 3' ZNRF4 hsa-miR-383 beg:34 end:47 pic:3' TCGGTGTTAGTGGAAGACTAGA 5'& .|||||.||| &5' ------------TTTCTGGTCT 3' ZNRF4 hsa-miR-384 beg:24 end:44 pic:3' ATACTTGT--TAAAGATCCTTA 5'& ||||. | .|||||.| &5' -ATGAGGAATGTTTCTGG---- 3' ZNRF4 hsa-miR-4258 beg:2 end:23 pic:3' GGTTCCG-CCACCGCCCC 5'& |.|.||| || | |||| &5' CTAGGGCAGGGAGGGGGG 3' ZNRF4 hsa-miR-4274 beg:8 end:26 pic:3' GTCCC-CCTCCCTGACGAC 5'& ||||| ||.||| ||| &5' CAGGGAGGGGGG--TGC-- 3' ZNRF4 hsa-miR-4290 beg:4 end:24 pic:3' CTCCCTTCTTTCCTCCCGT 5'& |||| || |||.|||. &5' -AGGGCAGGGAGGGGGGT- 3' ZNRF4 hsa-miR-4313 beg:5 end:24 pic:3' CCCAAACCCCGGTCCCCCGA 5'& ||| ||| .|||||. &5' GGGCA--GGGA-GGGGGGT- 3' ZNRF4 hsa-miR-4325 beg:8 end:27 pic:3' AGTGACTCTGTTCACGTT 5'& || |||. ..|||||| &5' -CAGGGAGGGGGGTGCAA 3' ZNRF4 hsa-miR-432star beg:5 end:27 pic:3' TCTGTACCTCCTCGGTAGGTC 5'& .|.|| |||||.| .| || &5' GGGCAGGGAGGGGG-GTGCA- 3' ZNRF4 hsa-miR-449cstar beg:11 end:35 pic:3' TGTCTCTCCTCACGTTGATCGTT 5'& .|||.||.||||||. || || &5' --GGAGGGGGGTGCAATGAGGAA 3' ZNRF4 hsa-miR-483-3p beg:5 end:25 pic:3' TTCTGCCC--TCCTCTCCTCACT 5'& ||| .||||.||.||| &5' -----GGGCAGGGAGGGGGGTG- 3' ZNRF4 hsa-miR-485-3p beg:9 end:31 pic:3' TCTCTCCTCTCGGCACATACTG 5'& ||.||||.|.|. |||| &5' AGGGAGGGGGGTGCA--ATGA- 3' ZNRF4 hsa-miR-498 beg:59 end:71 pic:3' CTTTTTGCGGGGGACCGAACTTT 5'& ||.|||||| &5' --------------GGTTTGAAA 3' ZNRF4 hsa-miR-500b beg:0 end:17 pic:3' TGGGTCCATCGTTCCTAA 5'& |.|.||| |||.||| &5' ATCTAGG--GCAGGGA-- 3' ZNRF4 hsa-miR-500star beg:17 end:27 pic:3' GTCTTAGGAACGGGTCCACGTA 5'& .|||||| &5' --------------GGGTGCA- 3' ZNRF4 hsa-miR-502-5p beg:0 end:17 pic:3' ATCGTGGGTCTATCGTTCCTA 5'& || |.|.|| .|||.||| &5' -AG-ATCTAG--GGCAGGGA- 3' ZNRF4 hsa-miR-543 beg:18 end:40 pic:3' TTCTTCACGTGGCG-CTTACAAA 5'& |..||||| .| |||||||| &5' --GGGGTGCAATGAGGAATGTTT 3' ZNRF4 hsa-miR-607 beg:57 end:70 pic:3' CAATATCTAGACCTAAACTTG 5'& |||.|||||| &5' ----------TGGGTTTGAA- 3' ZNRF4 hsa-miR-657 beg:2 end:26 pic:3' GGATCTC-TCCCACTCTTGGACGG 5'& ||||.| |||| |.|.. ||| &5' -CTAGGGCAGGGAGGGGGG-TGC- 3' ZNRF4 hsa-miR-670 beg:8 end:17 pic:3' GTGGTGTATGTGAGTCCCTG 5'& |||||| &5' -------------CAGGGA- 3' ZNRF4 hsa-miR-92a beg:7 end:30 pic:3' TGTCCGGCCCTGT--TCACGTTAT 5'& .||| |||| . .|||||||. &5' --GGGCAGGGAGGGGGGTGCAATG 3' ZNRF4 hsa-miR-92b beg:7 end:30 pic:3' CCTCCGGCCCTG--CTCACGTTAT 5'& .||| |||| |.|||||||. &5' --GGGCAGGGAGGGGGGTGCAATG 3' ZNRF4 hsv1-miR-H6-3p beg:5 end:25 pic:3' CCCTACCT-TCCTGCCCTTCAC 5'& ||. ||| |||..||| &5' -----GGGCAGGGAGGGGGGTG 3' ZNRF4 hsv2-miR-H24 beg:4 end:32 pic:3' TCCCGCCCC-CCTTCCGCGGC-CTC 5'& ||||| ||| ||..||.|| ||| &5' AGGGCAGGGAGGGGGGTGCAATGAG 3' ZNRF4 kshv-miR-K12-8star beg:5 end:22 pic:3' TCGCCCCGCAATCACTCCCTCA 5'& |||| .| |||||.| &5' ----GGGCA--GG-GAGGGGG- 3'

DNA & RNA Element - miRcode Gene Name Type microRNA Seed Position Seed Type Total Cons% Tr Region ZNRF4 High_conserved miR-503 chr19:5455778 7-mer-m8 4 CDS ZNRF4 High_conserved miR-503 chr19:5456210 7-mer-m8 0 CDS ZNRF4 High_conserved miR-93/93a/105/106a/291a-3p/294/295/302abcde/372/373/428/519a/520be/520acd-3p/1378/1420ac chr19:5455529 8-mer 4 CDS ZNRF4 High_conserved miR-141/200a chr19:5456141 7-mer-m8 2 CDS ZNRF4 High_conserved miR-150/5127 chr19:5455634 7-mer-A1 4 CDS ZNRF4 High_conserved miR-183 chr19:5455932 7-mer-m8 13 CDS ZNRF4 High_conserved miR-183 chr19:5456435 7-mer-m8 31 CDS ZNRF4 High_conserved miR-187 chr19:5455499 8-mer 13 5pUTR ZNRF4 High_conserved miR-18ab/4735-3p chr19:5456006 7-mer-m8 18 CDS ZNRF4 High_conserved miR-18ab/4735-3p chr19:5456408 7-mer-m8 22 CDS ZNRF4 High_conserved miR-192/215 chr19:5455912 7-mer-A1 11 CDS ZNRF4 High_conserved miR-1ab/206/613 chr19:5455592 7-mer-A1 11 CDS ZNRF4 High_conserved miR-214/761/3619-5p chr19:5456351 7-mer-m8 11 CDS ZNRF4 High_conserved miR-24/24ab/24-3p chr19:5455579 8-mer 18 CDS ZNRF4 High_conserved miR-25/32/92abc/363/363-3p/367 chr19:5456821 7-mer-m8 4 3pUTR ZNRF4 High_conserved miR-103a/107/107ab chr19:5456352 7-mer-A1 9 CDS ZNRF4 High_conserved miR-338/338-3p chr19:5455816 7-mer-A1 20 CDS ZNRF4 High_conserved miR-34ac/34bc-5p/449abc/449c-5p chr19:5455571 7-mer-m8 11 CDS ZNRF4 High_conserved miR-34ac/34bc-5p/449abc/449c-5p chr19:5456719 8-mer 9 CDS ZNRF4 High_conserved miR-125a-5p/125b-5p/351/670/4319 chr19:5456614 7-mer-A1 7 CDS ZNRF4 Medium_conserved miR-504/4725-5p chr19:5455551 7-mer-m8 11 CDS ZNRF4 Medium_conserved miR-542-3p chr19:5456250 7-mer-m8 11 CDS ZNRF4 Medium_conserved miR-543 chr19:5456831 7-mer-m8 16 3pUTR ZNRF4 Medium_conserved miR-149 chr19:5455544 7-mer-m8 4 CDS ZNRF4 Medium_conserved miR-320abcd/4429 chr19:5456589 7-mer-m8 9 CDS ZNRF4 Medium_conserved miR-370 chr19:5455548 7-mer-m8 4 CDS ZNRF4 Medium_conserved miR-378/422a/378bcdefhi chr19:5456670 7-mer-m8 2 CDS ZNRF4 Medium_conserved miR-379/1193-5p/3529 chr19:5456382 7-mer-m8 11 CDS ZNRF4 Medium_conserved miR-491-5p chr19:5456715 7-mer-m8 2 CDS ZNRF4 Medium_conserved miR-494 chr19:5456833 7-mer-m8 16 3pUTR

DNA & RNA Element - RAID2 Gene Name RAID ID Interactor 1 Category 1 ID 1 Interactor 2 Category 2 ID 2 Methods Score ZNRF4 RAID00435440 hsa-miR-543 miRNA MIMAT0004954 ZNRF4 mRNA 148066 Prediction 0.1828 ZNRF4 RAID00611225 hsa-miR-363-3p miRNA MIMAT0000707 ZNRF4 mRNA 148066 Prediction 0.1828 ZNRF4 RAID01429252 hsa-miR-367-3p miRNA MIMAT0000719 ZNRF4 mRNA 148066 Prediction 0.1828 ZNRF4 RAID02417940 hsa-miR-32-5p miRNA MIMAT0000090 ZNRF4 mRNA 148066 Prediction 0.1828 ZNRF4 RAID02711691 hsa-miR-92a-3p miRNA MIMAT0000092 ZNRF4 mRNA 148066 Prediction 0.1828 ZNRF4 RAID02867123 hsa-miR-92b-3p miRNA MIMAT0003218 ZNRF4 mRNA 148066 Prediction 0.1828 ZNRF4 RAID03022951 hsa-miR-494-3p miRNA MIMAT0002816 ZNRF4 mRNA 148066 Prediction 0.1828 ZNRF4 RAID03822076 hsa-miR-25-3p miRNA MIMAT0000081 ZNRF4 mRNA 148066 Prediction 0.1828