PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus UBE2G2 ZNRF4 19690564 biogrid,intact exp G G G G G G G G G G G G G G G G G G G G G UBE2D3 ZNRF4 19690564 biogrid,intact exp G G G G G G G G G G G G G G G G G G G G G ZNRF4 UBE2E3 19690564 biogrid,intact exp G G G G G G G G G G G G G G G G G G G G G UBE2D1 ZNRF4 19690564 biogrid,intact exp G G G G G G G G G G G G G G G G G G G G G UBE2N ZNRF4 19690564 biogrid,intact exp G G G G G G G G G G G G G G G G G G G G G ZNRF4 UBE2D4 19690564 biogrid,intact exp G G G G G G G G G G G G G G G G G G G G G UBE2D2 ZNRF4 19690564 biogrid,intact exp G G G G G G G G G G G G G G G G G G G G G CANX ZNRF4 21205830 biogrid exp G G G G G G G G G G G G G G G G G G G G G UBE2E1 ZNRF4 19690564 biogrid,intact exp G G G G G G G G G G G G G G G G G G G G G ZNRF4 UBE2W 19690564 biogrid,intact exp G G G G G G G G G G G G G G G G G G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants P61077-3 Q8WWF5 two hybrid 19690564 direct interaction X 2 A0A087WW00 Q8WWF5 two hybrid 19690564 direct interaction X 2 Q8WWF5 P60604-2 two hybrid 19690564 direct interaction X 2 P27824 Q8WWF5 affinity chromatography technology 21205830 physical association X 2 P27824 Q8WWF5 affinity chromatography technology 21205830 physical association X 2 Q969T4 Q8WWF5 two hybrid 19690564 direct interaction X 2 A0A024R2K3 Q8WWF5 two hybrid 19690564 direct interaction X 2 Q8WWF5 P62837 two hybrid 19690564 direct interaction X 2 Q8WWF5 A0A024RA90 two hybrid 19690564 direct interaction X 2 Q8WWF5 Q96FI0 two hybrid 19690564 direct interaction X 2 P61088 Q8WWF5 two hybrid 19690564 direct interaction X 2 A0A024RDH2 Q8WWF5 two hybrid array 19690564 physical association X 2 P60604 Q8WWF5 two hybrid array 19690564 physical association X 2 A0A024QZJ2 Q8WWF5 two hybrid array 19690564 physical association X 2 Q969T4 Q8WWF5 two hybrid array 19690564 physical association X 2 A0A024R2K3 Q8WWF5 two hybrid array 19690564 physical association X 2 Q8WWF5 P62837 two hybrid array 19690564 physical association X 2 Q8WWF5 A0A024RA90 two hybrid array 19690564 physical association X 2 P61088 Q8WWF5 two hybrid array 19690564 physical association X 2 Q96B02 Q8WWF5 two hybrid array 19690564 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B UBE2N ZNRF4 MI:0397(two hybrid array)|MI:0018(two hybrid) 19690564 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_102621|BIOGRID_123632 bait|bait prey|prey CANX ZNRF4 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 21205830 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_143387|BIOGRID_143388 prey|bait bait|prey UBE2D3 ZNRF4 MI:0397(two hybrid array)|MI:0018(two hybrid) 19690564 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_102494|BIOGRID_123504 bait|bait prey|prey ZNRF4 UBE2D4 MI:0397(two hybrid array)|MI:0018(two hybrid) 19690564 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_102526|BIOGRID_123536 prey|prey bait|bait UBE2E3 ZNRF4 MI:0397(two hybrid array)|MI:0018(two hybrid) 19690564 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_102561|BIOGRID_123572 bait|bait prey|prey UBE2W ZNRF4 MI:0018(two hybrid)|MI:0397(two hybrid array) 19690564 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_123711|UniProt_102699 bait|bait prey|prey UBE2G2 ZNRF4 MI:0018(two hybrid)|MI:0397(two hybrid array) 19690564 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_123584|UniProt_102573 bait|bait prey|prey UBE2E1 ZNRF4 MI:0397(two hybrid array)|MI:0018(two hybrid) 19690564 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_102544|BIOGRID_123555 bait|bait prey|prey UBE2D2 ZNRF4 MI:0397(two hybrid array)|MI:0018(two hybrid) 19690564 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_102460|BIOGRID_123472 bait|bait prey|prey UBE2D1 ZNRF4 MI:0397(two hybrid array)|MI:0018(two hybrid) 19690564 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_102428|BIOGRID_123438 bait|bait prey|prey

PPI - HINT Gene A Gene B PMID Method Quality UBE2D1 ZNRF4 19690564,19690564 0397,0018 HT UBE2E1 ZNRF4 19690564,19690564 0397,0018 HT UBE2G2 ZNRF4 19690564,19690564 0397,0018 HT UBE2D3 ZNRF4 19690564,19690564 0397,0018 HT UBE2N ZNRF4 19690564,19690564 0397,0018 HT UBE2D2 ZNRF4 19690564,19690564 0397,0018 HT ZNRF4 UBE2E3 19690564,19690564 0397,0018 HT ZNRF4 UBE2W 19690564,19690564 0397,0018 HT ZNRF4 UBE2D4 19690564,19690564 0397,0018 HT ZNRF4 HEL-S-71 19690564 0018 HT

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q8WWF5 P21589 ZNRF4 NT5E 0.236 unassigned1304 Q969T4 Q8WWF5 UBE2E3 ZNRF4 0.286 19690564 Q8WWF5 P51668 ZNRF4 UBE2D1 0.286 19690564 Q8WWF5 P51965 ZNRF4 UBE2E1 0.286 19690564 Q8WWF5 P61077 ZNRF4 UBE2D3 0.286 19690564 Q8WWF5 P27824 ZNRF4 CANX 0.376 21205830 Q8WWF5 P60604 ZNRF4 UBE2G2 0.376 19690564 Q8WWF5 P61088 ZNRF4 UBE2N 0.286 19690564 Q9Y2X8 Q8WWF5 UBE2D4 ZNRF4 0.376 19690564 Q8WWF5 P62837 ZNRF4 UBE2D2 0.286 19690564 Q96B02 Q8WWF5 UBE2W ZNRF4 0.376 19690564

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 CANX ZNRF4 MI:0045 experimental interaction detection MI:0461 interaction database UBE2D1 ZNRF4 MI:0045 experimental interaction detection MI:0461 interaction database UBE2E1 ZNRF4 MI:0045 experimental interaction detection MI:0461 interaction database UBE2G2 ZNRF4 MI:0045 experimental interaction detection MI:0461 interaction database UBE2D3 ZNRF4 MI:0045 experimental interaction detection MI:0461 interaction database UBE2N ZNRF4 MI:0045 experimental interaction detection MI:0461 interaction database UBE2D2 ZNRF4 MI:0045 experimental interaction detection MI:0461 interaction database ZNRF4 UBE2E3 MI:0045 experimental interaction detection MI:0461 interaction database ZNRF4 UBE2W MI:0045 experimental interaction detection MI:0461 interaction database ZNRF4 UBE2D4 MI:0045 experimental interaction detection MI:0461 interaction database