PTM - CPLM Gene Name UniProt ID Type Position Code USP42 Q9H9J4 Ubiquitination 327 K USP42 Q9H9J4 Ubiquitination 330 K

PTM - dbPAF Gene Name UniProt ID Position Type Species USP42 Q9H9J4 1007 S Homo sapiens(Human) USP42 Q9H9J4 1066 Y Homo sapiens(Human) USP42 Q9H9J4 1069 Y Homo sapiens(Human) USP42 Q9H9J4 1115 S Homo sapiens(Human) USP42 Q9H9J4 1116 S Homo sapiens(Human) USP42 Q9H9J4 1133 S Homo sapiens(Human) USP42 Q9H9J4 1166 S Homo sapiens(Human) USP42 Q9H9J4 1181 S Homo sapiens(Human) USP42 Q9H9J4 1213 S Homo sapiens(Human) USP42 Q9H9J4 1219 S Homo sapiens(Human) USP42 Q9H9J4 1222 S Homo sapiens(Human) USP42 Q9H9J4 1226 S Homo sapiens(Human) USP42 Q9H9J4 1247 S Homo sapiens(Human) USP42 Q9H9J4 1263 S Homo sapiens(Human) USP42 Q9H9J4 1280 S Homo sapiens(Human) USP42 Q9H9J4 237 Y Homo sapiens(Human) USP42 Q9H9J4 288 S Homo sapiens(Human) USP42 Q9H9J4 289 Y Homo sapiens(Human) USP42 Q9H9J4 422 T Homo sapiens(Human) USP42 Q9H9J4 425 T Homo sapiens(Human) USP42 Q9H9J4 427 S Homo sapiens(Human) USP42 Q9H9J4 431 S Homo sapiens(Human) USP42 Q9H9J4 432 S Homo sapiens(Human) USP42 Q9H9J4 438 S Homo sapiens(Human) USP42 Q9H9J4 479 S Homo sapiens(Human) USP42 Q9H9J4 483 S Homo sapiens(Human) USP42 Q9H9J4 494 S Homo sapiens(Human) USP42 Q9H9J4 499 S Homo sapiens(Human) USP42 Q9H9J4 602 S Homo sapiens(Human) USP42 Q9H9J4 607 Y Homo sapiens(Human) USP42 Q9H9J4 611 S Homo sapiens(Human) USP42 Q9H9J4 612 S Homo sapiens(Human) USP42 Q9H9J4 615 S Homo sapiens(Human) USP42 Q9H9J4 619 S Homo sapiens(Human) USP42 Q9H9J4 63 Y Homo sapiens(Human) USP42 Q9H9J4 630 T Homo sapiens(Human) USP42 Q9H9J4 72 S Homo sapiens(Human) USP42 Q9H9J4 75 S Homo sapiens(Human) USP42 Q9H9J4 754 S Homo sapiens(Human) USP42 Q9H9J4 759 S Homo sapiens(Human) USP42 Q9H9J4 772 T Homo sapiens(Human) USP42 Q9H9J4 783 T Homo sapiens(Human) USP42 Q9H9J4 829 S Homo sapiens(Human) USP42 Q9H9J4 832 S Homo sapiens(Human) USP42 Q9H9J4 856 S Homo sapiens(Human) USP42 Q9H9J4 919 S Homo sapiens(Human) USP42 Q9H9J4 936 S Homo sapiens(Human) USP42 Q9H9J4 953 Y Homo sapiens(Human)

PTM - PhosSNP Gene Name dbSNP ID Gene Mutation AA Mutation Mutation Position Code Peptide Score Modification Type USP42 rs61753119 AGT->AAT S->N 856 S AEAPEGLSPAPPARS 856 Phosphorylation TypeI- USP42 rs61732616 CTG->CGG L->R 754 S DAEPQPGSPAAESLE 754 Phosphorylation TypeIII-

PTM - PhosphositePlus UniProt ID MOD_RSD Type SITE_+/-7_AA Q9H9J4 K1184-ac Acetylation KARRsEQkDPLEEPk Q9H9J4 K1191-ac Acetylation kDPLEEPkAkkHKKS Q9H9J4 Y63-p Phosphorylation PVPGAVVySSSSVPD Q9H9J4 S72-p Phosphorylation SSSVPDKsKPsPQKD Q9H9J4 S75-p Phosphorylation VPDKsKPsPQKDQAL Q9H9J4 Y237-p Phosphorylation VCQIFGGyLRSRVKC Q9H9J4 S288-p Phosphorylation EQLDGENsyKCSKCK Q9H9J4 Y289-p Phosphorylation QLDGENsyKCSKCKK Q9H9J4 T422-p Phosphorylation VKNGGELtHPtHsPG Q9H9J4 T425-p Phosphorylation GGELtHPtHsPGQss Q9H9J4 S427-p Phosphorylation ELtHPtHsPGQssPR Q9H9J4 S431-p Phosphorylation PtHsPGQssPRPVIs Q9H9J4 S432-p Phosphorylation tHsPGQssPRPVIsQ Q9H9J4 S438-p Phosphorylation ssPRPVIsQRVVTNK Q9H9J4 S479-p Phosphorylation PLKDTPSsSMSsPNG Q9H9J4 S483-p Phosphorylation TPSsSMSsPNGNSSV Q9H9J4 S494-p Phosphorylation NSSVNRAsPVNASAS Q9H9J4 Y607-p Phosphorylation NSSVLVPyGAEssED Q9H9J4 S611-p Phosphorylation LVPyGAEssEDsDEE Q9H9J4 S612-p Phosphorylation VPyGAEssEDsDEEs Q9H9J4 S615-p Phosphorylation GAEssEDsDEEsKGL Q9H9J4 S619-p Phosphorylation sEDsDEEsKGLGKEN Q9H9J4 S754-p Phosphorylation DAEPQPGsPAAEsLE Q9H9J4 S759-p Phosphorylation PGsPAAEsLEEPdAA Q9H9J4 T783-p Phosphorylation PPPRDPGtPATKEGA Q9H9J4 S829-p Phosphorylation GSLTGDAsPLsQDAK Q9H9J4 S832-p Phosphorylation TGDAsPLsQDAKGMI Q9H9J4 S856-p Phosphorylation AEAPEGLsPAPPARS Q9H9J4 S919-p Phosphorylation PEGDAEPsPGERVED Q9H9J4 S936-p Phosphorylation APKAPGPsPAKEKIG Q9H9J4 Y953-p Phosphorylation RKVDRGHyRSRRERS Q9H9J4 S1007-p Phosphorylation PGHGDRLsPGERRSL Q9H9J4 S1026-p Phosphorylation HHHSRHRsGVELDWV Q9H9J4 Y1066-p Phosphorylation CRYYHDRyALyAARD Q9H9J4 Y1069-p Phosphorylation YHDRyALyAARDWKP Q9H9J4 S1115-p Phosphorylation ERERHRPssPRAGAP Q9H9J4 S1116-p Phosphorylation RERHRPssPRAGAPH Q9H9J4 S1133-p Phosphorylation APHPDRFsHDRTALV Q9H9J4 S1148-p Phosphorylation AGDNCNLsDRFHEHE Q9H9J4 S1166-p Phosphorylation SRKRRHDsVENsDSH Q9H9J4 S1170-p Phosphorylation RHDsVENsDSHVEKK Q9H9J4 S1181-p Phosphorylation VEKKARRsEQkDPLE Q9H9J4 S1213-p Phosphorylation DKHRDRDsRHQQDsD Q9H9J4 S1219-p Phosphorylation DsRHQQDsDLsAACs Q9H9J4 S1222-p Phosphorylation HQQDsDLsAACsDAD Q9H9J4 S1226-p Phosphorylation sDLsAACsDADLHRH Q9H9J4 S1247-p Phosphorylation KKRHSRKsEDFVKDS Q9H9J4 S1263-p Phosphorylation LHLPRVTsLETVAQF Q9H9J4 S1280-p Phosphorylation AQGGFPLsGGPPLEG Q9H9J4 K327-ub Ubiquitination FANFTGGkIAKDVKY Q9H9J4 K1191-ub Ubiquitination kDPLEEPkAkkHKKS Q9H9J4 K1193-ub Ubiquitination PLEEPkAkkHKKSKK Q9H9J4 K1194-ub Ubiquitination LEEPkAkkHKKSKKK

PTM - dbPTM UniProt ID Position Code Type Resources References Q9H9J4 754 S Phosphorylation Swiss-Prot 1010711 15302935 Q9H9J4 856 S Phosphorylation Swiss-Prot 1010711 15302935;17081983;18669648;19413330;19690332 Q9H9J4 953 Y Phosphorylation Swiss-Prot 1010711 18691976 Q9H9J4 1219 S Phosphorylation Swiss-Prot 1010711 18669648 Q9H9J4 1222 S Phosphorylation Swiss-Prot 1010711 18669648 Q9H9J4 1226 S Phosphorylation Swiss-Prot 1010711 17081983;18669648 Q9H9J4 611 S Phosphorylation PhosphoELM.10011 18669648 Q9H9J4 612 S Phosphorylation PhosphoELM.10011 18669648 Q9H9J4 615 S Phosphorylation PhosphoELM.10011 18669648 Q9H9J4 619 S Phosphorylation PhosphoELM.10011 18669648 Q9H9J4 754 S Phosphorylation PhosphoELM.10011 15302935 Q9H9J4 856 S Phosphorylation PhosphoELM.10011 18669648;17081983;15302935 Q9H9J4 1219 S Phosphorylation PhosphoELM.10011 18669648 Q9H9J4 1222 S Phosphorylation PhosphoELM.10011 18669648 Q9H9J4 1226 S Phosphorylation PhosphoELM.10011 18669648;17081983 Q9H9J4 764 D Caspase Phosphositeplus.1010730 18722006 Q9H9J4 1219 S Phosphorylation Phosphositeplus.1010730 18669648;20068231;21406692;21659604 Q9H9J4 1222 S Phosphorylation Phosphositeplus.1010730 18669648;20068231;21406692;21659604 Q9H9J4 1226 S Phosphorylation Phosphositeplus.1010730 18669648;20068231;21406692;21659604 Q9H9J4 1247 S Phosphorylation Phosphositeplus.1010730 21406692 Q9H9J4 1280 S Phosphorylation Phosphositeplus.1010730 20068231 Q9H9J4 611 S Phosphorylation Phosphositeplus.1010730 20068231;21406692;22115753 Q9H9J4 612 S Phosphorylation Phosphositeplus.1010730 20068231;21406692;22115753 Q9H9J4 615 S Phosphorylation Phosphositeplus.1010730 21406692;22115753 Q9H9J4 619 S Phosphorylation Phosphositeplus.1010730 22115753 Q9H9J4 754 S Phosphorylation Phosphositeplus.1010730 15302935;19664995;21406692 Q9H9J4 829 S Phosphorylation Phosphositeplus.1010730 20068231 Q9H9J4 832 S Phosphorylation Phosphositeplus.1010730 20068231;21406692 Q9H9J4 856 S Phosphorylation Phosphositeplus.1010730 15302935;18669648;19415658;19664995;19690332;20068231;20363803;20815410;21406692 Q9H9J4 1069 Y Phosphorylation Phosphositeplus.1010730 21403953;21447384 Q9H9J4 953 Y Phosphorylation Phosphositeplus.1010730 18691976 Q9H9J4 483 S Phosphorylation HPRD 9.0 18452278 Q9H9J4 611 S Phosphorylation HPRD 9.0 18669648,20068231 Q9H9J4 612 S Phosphorylation HPRD 9.0 18669648,20068231 Q9H9J4 615 S Phosphorylation HPRD 9.0 18669648,19651622,20068231 Q9H9J4 619 S Phosphorylation HPRD 9.0 18669648 Q9H9J4 754 S Phosphorylation HPRD 9.0 19664995,18452278,20068231 Q9H9J4 759 S Phosphorylation HPRD 9.0 20068231 Q9H9J4 829 S Phosphorylation HPRD 9.0 20068231 Q9H9J4 832 S Phosphorylation HPRD 9.0 20068231 Q9H9J4 856 S Phosphorylation HPRD 9.0 17081983,18669648,19415658,19664995,19651622,19413330,18452278,20068231 Q9H9J4 919 S Phosphorylation HPRD 9.0 18452278 Q9H9J4 936 S Phosphorylation HPRD 9.0 19651622 Q9H9J4 1219 S Phosphorylation HPRD 9.0 18669648,20068231 Q9H9J4 1222 S Phosphorylation HPRD 9.0 18669648,20068231 Q9H9J4 1226 S Phosphorylation HPRD 9.0 17081983,18669648,20068231 Q9H9J4 1247 S Phosphorylation HPRD 9.0 18452278 Q9H9J4 1280 S Phosphorylation HPRD 9.0 20068231 Q9H9J4 772 T Phosphorylation HPRD 9.0 20068231 Q9H9J4 953 Y Phosphorylation HPRD 9.0 18691976 Q9H9J4 856 S Phosphorylation SysPTM 1.1 18669648;17081983 Q9H9J4 1219 S Phosphorylation SysPTM 1.1 18669648 Q9H9J4 1222 S Phosphorylation SysPTM 1.1 18669648 Q9H9J4 1226 S Phosphorylation SysPTM 1.1 18669648;17081983 Q9H9J4 953 Y Phosphorylation SysPTM 1.1 18691976

PTM - HPRD Symbol Position Code Type References USP42 1219 S Phosphorylation 18669648,20068231 USP42 1222 S Phosphorylation 18669648,20068231 USP42 1226 S Phosphorylation 17081983,18669648,20068231 USP42 1247 S Phosphorylation 18452278 USP42 1280 S Phosphorylation 20068231 USP42 483 S Phosphorylation 18452278 USP42 611 S Phosphorylation 18669648,20068231 USP42 612 S Phosphorylation 18669648,20068231 USP42 615 S Phosphorylation 18669648,19651622,20068231 USP42 619 S Phosphorylation 18669648 USP42 754 S Phosphorylation 19664995,18452278,20068231 USP42 759 S Phosphorylation 20068231 USP42 772 T Phosphorylation 20068231 USP42 829 S Phosphorylation 20068231 USP42 832 S Phosphorylation 20068231 USP42 856 S Phosphorylation 17081983,18669648,19415658,19664995,19651622,19413330,18452278,20068231 USP42 919 S Phosphorylation 18452278 USP42 936 S Phosphorylation 19651622 USP42 953 Y Phosphorylation 18691976

PTM - Phospho.ELM UniProt Position Code PMIDs Kinase Source Type Q9H9J4 611 S 18669648 HTP Phosphorylation Q9H9J4 1223 S 18669648 HTP Phosphorylation Q9H9J4 612 S 18669648 HTP Phosphorylation Q9H9J4 1220 S 18669648 HTP Phosphorylation Q9H9J4 619 S 18669648 HTP Phosphorylation Q9H9J4 856 S 18669648 HTP Phosphorylation Q9H9J4 856 S 17081983 HTP Phosphorylation Q9H9J4 856 S 15302935 HTP Phosphorylation Q9H9J4 1227 S 18669648 HTP Phosphorylation Q9H9J4 1227 S 17081983 HTP Phosphorylation Q9H9J4 754 S 15302935 HTP Phosphorylation Q9H9J4 615 S 18669648 HTP Phosphorylation

PTM - UniProt UniProt ID Position Type PMIDs Q9H9J4 75 Phosphoserine 23186163 Q9H9J4 483 Phosphoserine 23186163 Q9H9J4 754 Phosphoserine 23186163 Q9H9J4 856 Phosphoserine 18669648;19690332;20068231;21406692;23186163;24275569 Q9H9J4 1181 Phosphoserine 23186163 Q9H9J4 1226 Phosphoserine 17081983 Q9H9J4 1247 Phosphoserine 23186163

PTM - PHOSIDA Symbol Accession Code Position Surrounding Sequence Type USP42 IPI00375124 S 1227 DLSAACpSDADLHR phosphorylation USP42 IPI00375124 S 1281 QGGFPLpSGGPPLE phosphorylation USP42 IPI00375124 S 611 VPYGAEpSSEDSDE phosphorylation USP42 IPI00375124 S 612 PYGAESpSEDSDEE phosphorylation USP42 IPI00375124 S 615 AESSEDpSDEESKG phosphorylation USP42 IPI00375124 S 754 AEPQPGpSPAAESL phosphorylation USP42 IPI00375124 S 829 SLTGDApSPLSQDA phosphorylation USP42 IPI00375124 S 832 GDASPLpSQDAKGM phosphorylation USP42 IPI00375124 S 856 EAPEGLpSPAPPAR phosphorylation USP42 IPI00375124 Y 953 KVDRGHpYRSRRER phosphorylation

PTM - BioGRID Entrez Gene BioGRID ID Position Code Type PMIDs 84132 123904 - K Ubiquitination 22118674 84132 123904 - K Ubiquitination 21139048 84132 123904 - K Ubiquitination 21890473 84132 123904 - K Ubiquitination 25147182

PTM - mUbiSiDa Gene Name Species Ubiquitination Site Ubiquitination Sequence Evidence PMID USP42 Homo sapiens (Human) 327 "327,ANFTGGKIAKDVK" 327:21890473 USP42 Homo sapiens (Human) 327 "327,ANFTGGKIAKDVK" 327:21890473 USP42 Homo sapiens (Human) 327 "327,ANFTGGKIAKDVK" 327:21890473 USP42 Homo sapiens (Human) 327 "327,ANFTGGKIAKDVK" 327:21890473 USP42 Homo sapiens (Human) 327 "327,ANFTGGKIAKDVK" 327:21890473 USP42 Homo sapiens (Human) 290 "290,ANFTGGKIAKDVK" 290:21890473 USP42 Homo sapiens (Human) 327 "327,ANFTGGKIAKDVK" 327:21890473