PTM - CPLM Gene Name UniProt ID Type Position Code DDX58 O95786 Acetylation 858 K DDX58 O95786 Acetylation 909 K DDX58 O95786 Ubiquitination 644 K DDX58 O95786 Ubiquitination 172 K DDX58 O95786 Ubiquitination 759 K DDX58 O95786 Ubiquitination 757 K DDX58 O95786 Ubiquitination 666 K DDX58 O95786 Ubiquitination 292 K DDX58 O95786 Ubiquitination 455 K DDX58 O95786 Ubiquitination 788 K DDX58 O95786 Ubiquitination 177 K DDX58 O95786 Ubiquitination 115 K DDX58 O95786 Ubiquitination 858 K DDX58 O95786 Ubiquitination 312 K DDX58 O95786 Ubiquitination 307 K DDX58 O95786 Ubiquitination 880 K

PTM - dbPAF Gene Name UniProt ID Position Type Species DDX58 O95786 170 T Homo sapiens(Human) DDX58 O95786 197 T Homo sapiens(Human) DDX58 O95786 40 Y Homo sapiens(Human) DDX58 O95786 770 T Homo sapiens(Human) DDX58 O95786 8 S Homo sapiens(Human) DDX58 O95786 854 S Homo sapiens(Human) DDX58 O95786 855 S Homo sapiens(Human) DDX58 O95786 879 Y Homo sapiens(Human)

PTM - PhosphositePlus UniProt ID MOD_RSD Type SITE_+/-7_AA O95786 K858-ac Acetylation KQFssFEkRAKIFCA O95786 K909-ac Acetylation QTLYSKWkDFHFEKI O95786 S8-p Phosphorylation MTTEQRRsLQAFQDY O95786 Y40-p Phosphorylation FREEEVQyIQAEKNN O95786 T170-p Phosphorylation DkENWPktLkLALEK O95786 T197-p Phosphorylation kGIkDVEtEDLEDKM O95786 S468-p Phosphorylation RKVESRIsDKFKyII O95786 Y473-p Phosphorylation RIsDKFKyIIAQLMR O95786 S654-p Phosphorylation IEGNPKLsFLKPGIL O95786 T667-p Phosphorylation ILTGRGKtNQNtGMt O95786 T671-p Phosphorylation RGKtNQNtGMtLPAQ O95786 T674-p Phosphorylation tNQNtGMtLPAQKCI O95786 S764-p Phosphorylation KEKMMNDsILRLQtW O95786 T770-p Phosphorylation DsILRLQtWDEAVFR O95786 S854-p Phosphorylation HPKPKQFssFEkRAK O95786 S855-p Phosphorylation PKPKQFssFEkRAKI O95786 Y879-p Phosphorylation DWGIHVKyKTFEIPV O95786 K96-sm Sumoylation IESWDFKkIEkLEEY O95786 K888-sm Sumoylation TFEIPVIkIESFVVE O95786 K99-ub Ubiquitination WDFKkIEkLEEYRLL O95786 K115-ub Ubiquitination KRLQPEFkTRIIPTD O95786 K146-ub Ubiquitination ILQICSTkGMMAGAE O95786 K154-ub Ubiquitination GMMAGAEkLVECLLR O95786 K164-ub Ubiquitination ECLLRSDkENWPktL O95786 K169-ub Ubiquitination SDkENWPktLkLALE O95786 K172-ub Ubiquitination ENWPktLkLALEKER O95786 K181-ub Ubiquitination ALEKERNkFSELWIV O95786 K190-ub Ubiquitination SELWIVEkGIkDVEt O95786 K193-ub Ubiquitination WIVEkGIkDVEtEDL O95786 K644-ub Ubiquitination RALVDALkNWIEGNP O95786 K796-ub Ubiquitination FIRDSQEkPKPVPDK O95786 K812-ub Ubiquitination NKKLLCRkCKALACY

PTM - dbPTM UniProt ID Position Code Type Resources References O95786 770 T Phosphorylation Swiss-Prot 1010711 21068236 O95786 854 S Phosphorylation Swiss-Prot 1010711 21068236 O95786 855 S Phosphorylation Swiss-Prot 1010711 21068236 O95786 858 K Acetylation Swiss-Prot 1010711 19608861 O95786 909 K Acetylation Swiss-Prot 1010711 19608861 O95786 154 K Ubiquitylation Phosphositeplus.1010730 19484123 O95786 164 K Ubiquitylation Phosphositeplus.1010730 19484123 O95786 169 K Ubiquitylation Phosphositeplus.1010730 17392790 O95786 172 K Ubiquitylation Phosphositeplus.1010730 17392790;19484123;20071582;20403326 O95786 181 K Ubiquitylation Phosphositeplus.1010730 17392790 O95786 190 K Ubiquitylation Phosphositeplus.1010730 17392790 O95786 193 K Ubiquitylation Phosphositeplus.1010730 17392790 O95786 644 K Ubiquitylation Phosphositeplus.1010730 21906983 O95786 99 K Ubiquitylation Phosphositeplus.1010730 17392790 O95786 858 K Acetylation Phosphositeplus.1010730 19608861 O95786 909 K Acetylation Phosphositeplus.1010730 19608861 O95786 8 S Phosphorylation Phosphositeplus.1010730 20071582;20406818;22114345 O95786 854 S Phosphorylation Phosphositeplus.1010730 21068236 O95786 855 S Phosphorylation Phosphositeplus.1010730 21068236 O95786 170 T Phosphorylation Phosphositeplus.1010730 20071582;22114345 O95786 197 T Phosphorylation Phosphositeplus.1010730 20071582 O95786 770 T Phosphorylation Phosphositeplus.1010730 21068236 O95786 858 K Acetylation HPRD 9.0 19608861 O95786 909 K Acetylation HPRD 9.0 19608861

PTM - HPRD Symbol Position Code Type References DDX58 858 K Acetylation 19608861 DDX58 909 K Acetylation 19608861

PTM - UniProt UniProt ID Position Type PMIDs O95786 770 Phosphothreonine; by CK2 21068236 O95786 854 Phosphoserine; by CK2 21068236 O95786 855 Phosphoserine; by CK2 21068236 O95786 858 N6-acetyllysine 19608861

PTM - PHOSIDA Symbol Accession Code Position Surrounding Sequence Type DDX58 IPI00295503 K 813 QFSSFEaKRAKIFC acetylation DDX58 IPI00295503 K 864 TLYSKWaKDFHFEK acetylation

PTM - BioGRID Entrez Gene BioGRID ID Position Code Type PMIDs 23586 117121 - K Ubiquitination 18636086 23586 117121 - K ISG15ylation 17719635 23586 117121 - K Ubiquitination 17719635 23586 117121 - K Ubiquitination 17392790 23586 117121 - K Ubiquitination 21835791 23586 117121 - K Ubiquitination 19996094 23586 117121 - K Ubiquitination 20071582 23586 117121 - K Ubiquitination 19454348 23586 117121 - K Ubiquitination 21292167 23586 117121 - K Ubiquitination 22022264 23586 117121 - K Ubiquitination 21910972 23586 117121 - K Ubiquitination 22114345 23586 117121 - K Ubiquitination 21906983 23586 117121 - K Ubiquitination 23209422 23586 117121 - K Ubiquitination 23388719 23586 117121 - K Ubiquitination 23399697 23586 117121 - K Ubiquitination 23000965 23586 117121 - K Ubiquitination 23950712 23586 117121 - K Ubiquitination 24493797 23586 117121 - K Ubiquitination 24622840 23586 117121 - K Ubiquitination 24366338 23586 117121 - K Ubiquitination 24706898 23586 117121 - K Ubiquitination 19484123

PTM - mUbiSiDa Gene Name Species Ubiquitination Site Ubiquitination Sequence Evidence PMID DDX58 Homo sapiens (Human) 599 "599,ALVDALKNWIEGN" 599:21906983 DDX58 Homo sapiens (Human) 644 "644,ALVDALKNWIEGN" 644:21906983