PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus MAP3K1 RNF141 25260751 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G ELAVL1 RNF141 19322201 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP G GP GP G TRIM24 RNF141 22493164 biogrid,intact exp G G G G G G G G GP G G G GP GP G GP G GP G G GP GP GP GP GP G GP GP G RNF141 SMURF1 15761153 hprd,i2d exp G GP G G GP GP G G GP G GP G GP G G G GP GP G G GP G G G G GP G GP G RNF141 TRIM8 22493164 biogrid,intact exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G DTX3 RNF141 22493164 biogrid,intact exp GP GP G G GP GP G GP GP G GP GP G G G GP GP GP P G G G GP GP GP GP GP GP G UBC RNF141 ortho GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G LDB3 RNF141 23023127 pred G GP G G G GP G G GP G G G G G G G GP G G GP G G GP G RNF141 RNF125 23023127 pred GP GP G G GP GP G G GP G GP G GP GP G GP GP GP GP G GP GP GP GP GP GP GP P G RNF144A RNF141 23023127 pred G GP G G GP GP G GP GP G GP P GP GP G GP GP GP GP G P G GP GP GP GP GP P G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q8WVD5 A0A024RB96 two hybrid 22493164 direct interaction X 2 Q8WVD5 Q9BZR9 two hybrid 22493164 direct interaction X 2 Q8WVD5 O15164 two hybrid 22493164 direct interaction X 2 Q8WVD5 Q9HCE7-2 in vivo 15761153 - X 2 Q8WVD5 Q9HCE7-2 in vivo 15761153 - X 2 Q8WVD5 ubiquitinase assay 25260751 ubiquitination reaction C 5 Q8WVD5 Q9BZR9 two hybrid array 22493164 physical association X 2 Q8WVD5 A0A024RB96 two hybrid array 22493164 physical association X 2 Q8WVD5 O15164 two hybrid array 22493164 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B TRIM24 RNF141 MI:0397(two hybrid array) 22493164 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (intact) UniProt_122510 prey bait RNF141 SMURF1 MI:0493(in vivo) 15761153 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) - MI:0468(hprd) HPRD_17972 - - DTX3 RNF141 MI:0397(two hybrid array) 22493164 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (intact) UniProt_122545 prey bait RNF141 TRIM8 MI:0397(two hybrid array) 22493164 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (intact) UniProt_122544 prey bait

PPI - HINT Gene A Gene B PMID Method Quality TRIM24 RNF141 22493164,22493164 0018,0397 HT MAP3K1 RNF141 25260751 0415 LC DTX3 RNF141 22493164,22493164 0018,0397 HT RNF141 TRIM8 22493164,22493164 0018,0397 HT RNF141 SMURF1 15761153 0019 HT

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q8WVD5 Q62925 RNF141 MAP3K1 0.033 25260751 Q9H4B4 Q8WVD5 PLK3 RNF141 0.236 unassigned1304 Q8WVD5 O15164 RNF141 TRIM24 0.286 22493164 Q8WVD5 Q8N9I9 RNF141 DTX3 0.286 22493164 Q9BZR9 Q8WVD5 TRIM8 RNF141 0.286 22493164 Q8WVD5 Q15717 RNF141 ELAVL1 0.126 19322201 Q8WVD5 Q13233 RNF141 MAP3K1 0.183 25260751

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 TRIM24 RNF141 MI:0045 experimental interaction detection MI:0461 interaction database MYC RNF141 MI:0045 experimental interaction detection MI:0461 interaction database UBC RNF141 MI:0362 inference MI:0461 interaction database MAX RNF141 MI:0045 experimental interaction detection MI:0461 interaction database UBE2D2 RNF141 MI:0362 inference MI:0461 interaction database MAP3K1 RNF141 MI:0045 experimental interaction detection MI:0461 interaction database ELAVL1 RNF141 MI:0045 experimental interaction detection MI:0461 interaction database DTX3 RNF141 MI:0045 experimental interaction detection MI:0461 interaction database RNF141 TRIM8 MI:0045 experimental interaction detection MI:0461 interaction database RNF141 SMURF1 MI:0045 experimental interaction detection MI:0461 interaction database