PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus FOXL2 UBE4A 25609649 intact exp G G G G G B4GALT3 UBE4A 26186194 biogrid exp GP GP G G G GP G G GP G GP G GP GP G GP GP G GP G GP GP GP GP GP G GP GP G VAPB UBE4A 26186194 biogrid exp GP GP G G G GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP G GP GP G NTRK1 UBE4A 25921289 biogrid exp P P P G P P P P P P P P P P P P P P P CASP6 UBE4A 11802788 biogrid exp GP G G G G G GP GP G G GP G GP GP GP P GP GP GP G GP G UBE4A ELAVL1 19322201 biogrid exp GP GP G G G GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP G GP GP G UBE4A FOXQ1 25609649 intact exp GP G G G GP G GP GP G GP G GP GP G GP GP G G G GP GP GP G GP G GP GP G UBE4A MAVS 21903422 innatedb,biogrid,intact exp GP GP G G G GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP G GP GP G UBE4A FOXB1 25609649 intact exp FOXL1 UBE4A 25609649 intact exp G G UBE4A VIMP 22119785 biogrid exp GP GP G G G GP G G GP G GP GP GP GP G GP GP GP GP G GP GP GP G GP G GP GP G CBX7 UBE4A 21282530 biogrid,intact exp GP GP G G G GP G G GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP G GP GP G EPHA2 UBE4A 24457997 biogrid exp GP GP G P G GP GP G GP GP GP GP G GP GP P GP G GP GP GP GP GP G GP GP G UBE4A FOXI2 25609649 intact exp SLA UBE4A 24457997 biogrid exp G GP G G G GP G G GP G GP G GP GP G GP GP G GP G GP G GP GP GP G GP GP G UBE4A Mono [ADP-ribose] polymerase PARP16 26186194 biogrid exp GP G G G G GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP G GP GP G PTP4A3 UBE4A 17353931 biogrid,intact exp G GP G G G G G G G G G G G G G GP G GP G G G G G G GP G GP G G UBE4A UBXN4 26186194,22119785 biogrid exp GP GP G G G GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP G GP GP G PTTG1 UBE4A 15611659 biogrid exp GP G G G G G G G GP G G G G GP G GP G G G G GP G G G GP G G GP G IL9R UBE4A 26186194 biogrid exp GP GP G G G GP G GP GP GP GP GP GP G GP GP GP GP G P P GP GP GP G GP P G VCP UBE4A 15189447 hprd exp, ortho GP GP G G G GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP G GP GP G GZMB UBE4A 11802788, 21836163 hprd,biogrid,bci exp, pred G G G G G GP G G G G G G UBE2D2 UBE4A 19690564, 23023127 biogrid,intact exp, pred GP G G G G GP G G GP G GP GP GP GP G G GP GP GP G GP GP G GP G G GP GP G UBE4A UBE2D4 19690564, 23023127 biogrid,intact exp, pred GP G G G G GP G G GP G GP GP GP GP G G GP GP GP G GP GP G GP G G GP GP G UBE2D3 UBE4A 19690564,15611659, 23023127 biogrid,intact exp, pred GP G G G G GP G G GP G GP GP GP GP G G GP GP GP G GP GP G GP G G GP GP G UBE2D1 UBE4A 19690564, 23023127 biogrid,intact exp, pred GP G G G G GP G G GP G GP GP GP GP G G GP GP GP G GP GP G GP G G GP GP G UBE4A ITPR1 ortho G G G G G GP G GP G G GP GP GP G G GP G G G GP G G G GP GP G UBE4A DNAJC7 ortho GP GP G G G GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP G GP GP G UBE4A UBE4A 23023127 ortho, pred GP GP G G G GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP G GP GP G UBE4A TRAF7 23023127, 21836163 pred GP GP G G G GP G GP GP G GP GP GP G G GP GP G G G G G GP GP GP G GP GP G UBE4A GHITM 21836163 pred GP GP G G G GP G GP GP G GP G GP G G GP GP G GP G GP GP G G GP G GP GP G UBE4A UFD1L 21836163 pred G GP G G G GP G GP GP G GP G GP GP G GP GP G GP G GP GP G GP GP G G GP G UBE4A USP33 25402006 pred GP GP G G G GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP G GP GP G HNRNPR UBE4A 21836163 pred GP GP G G G GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP G GP GP G PSMD14 UBE4A 21836163 pred GP GP G G G GP G GP GP G GP GP GP G G GP GP GP GP G GP G G GP GP G GP GP G UBE4A PSME4 21836163 pred GP GP G G G GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP G GP GP G UBE4A RNF144B 21836163 pred G GP G G G GP G GP GP G GP GP GP G G GP GP GP GP G GP G G G GP G G GP G UBE4A UBQLN2 21836163 pred GP GP G G G GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP G GP GP G PSMA6 UBE4A 21836163 pred P P P P P P P P P P P P P P P P P P P UBB UBE4A 21836163 pred GP GP G G G GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP G GP GP G UBE4A UBA3 21836163 pred GP GP G G G GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP G GP GP G CUL4A UBE4A 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G UBE4A UBE2E3 23023127 pred GP GP G G G GP G G GP G GP G G GP G GP GP GP G G GP G G GP GP G GP GP G UBE4A UBE2NL 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G UBE2E1 UBE4A 23023127 pred GP GP G G G GP G G GP G GP G G GP G GP GP GP G G GP G G GP GP G GP GP G UBE4A FBXO11 21836163 pred G G G G G GP G G G G G GP GP G G GP GP G G G GP G G G GP G G G G UBE4A CHFR 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G UBE4A RNF41 23023127 pred GP GP G G G GP G GP GP G GP P G G GP GP P P G P G P GP GP G GP P AGFG1 UBE4A 23023127 pred GP GP G G G GP G G GP G GP GP GP GP G GP GP GP GP G GP GP G G GP G GP GP G UBE4A ARIH1 23023127, 21836163 pred GP GP G G G GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP G GP GP G PSMC3 UBE4A 21836163 pred GP GP G G G GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP G GP GP G UBE4A PTGES3 21836163 pred GP GP G G G GP G G GP G GP G GP GP G GP GP GP GP G GP GP GP G GP G GP GP G DHX15 UBE4A 21836163 pred G GP G G G GP G G GP G GP G G G G G GP GP GP G GP G G G G G GP GP G UBC UBE4A 21836163 pred GP GP G G G GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP G GP GP G UBE4A UBE2S 23023127 pred G G G G G G G G GP G G G GP G G G G G G G G G G G GP G UBE4A UBE2Q2 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G NDUFAB1 UBE4A 21836163 pred GP GP G G G GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP G GP G GP GP G UBE4A UBE2R2 23023127 pred G G G G G G G G G G G G G GP G G G G G G G G G G G G GP G G UBE2N UBE4A 23023127 pred GP GP G G G GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP G GP GP G PSMC1 UBE4A 21836163 pred GP GP G G G GP G G GP G GP GP GP GP G GP GP GP GP G GP GP GP G GP G GP GP G GNG5 UBE4A 21836163 pred GP GP G G G GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP G GP GP G USP5 UBE4A 21836163 pred GP GP G G G GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP G GP GP G GP GP G UBE4A USP13 23023127 pred GP GP G G G GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP G GP GP G UBE4A USP20 23023127 pred GP GP G G G GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP G GP GP G EIF1B UBE4A 21836163 pred G G G G G GP G G GP G G G G G G G GP G G G GP G G G G G G G G UBE2A UBE4A 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G ANXA7 UBE4A 21836163 pred GP GP G G G GP G GP GP G GP GP GP GP G G GP GP GP G GP GP GP GP G G GP GP G YWHAB UBE4A 21836163 pred GP GP G G G GP G G GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP G GP GP G UBE2M UBE4A 23023127 pred GP GP G G G GP G GP GP G GP G GP GP G GP GP GP GP G GP G GP GP GP G GP GP G PITPNB UBE4A 21836163 pred G GP G G G G G G GP G GP G G G G G G G GP G GP G G G G G G G G UBE4A FBXO7 21836163 pred GP GP G G G GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP G GP GP G RAD23A UBE4A 21836163 pred GP GP G G G GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP G GP GP G FBXW4 UBE4A 21836163 pred G G G G G G G G G G G G GP G G GP G G GP G GP G G G GP G G G G CDC34 UBE4A 23023127 pred GP GP G G G GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP G GP GP G UBE4A UBE2E2 23023127 pred GP GP G G G GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP G GP GP G UBE2G1 UBE4A 23023127 pred GP GP G G G GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP G GP GP G USP1 UBE4A 21836163 pred GP GP G G G GP G G GP G GP GP G GP G GP GP G G G GP G GP GP GP G GP GP G UBE4A PHF20 21836163 pred GP GP G G G GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP G GP GP G SRP9 UBE4A 21836163 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G UBE4A RNF14 23023127 pred GP GP G G G GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP G GP GP G UBE4A DDX1 21836163 pred GP GP G G G GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP G GP GP G WWP2 UBE4A 21836163 pred GP GP G G G GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP G GP GP G UBE4A FBXL3 21836163 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G UBE4A RNF125 23023127 pred GP GP G G G GP G G GP G GP G GP GP G GP GP GP GP G GP GP GP GP GP G GP P G CALM1, CALM2, CALM3 UBE4A 21836163 pred GP GP G G G GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP G GP GP G UBE4A OTUB1 21836163 pred GP GP G G G GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP G GP GP G UBE2V1 UBE4A 23023127 pred UBE4A RNF151 23023127 pred P G G G GP GP GP GP G P G GP G G P GP G G GP NAP1L1 UBE4A 21836163 pred GP GP G G G GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP G GP GP G UBE2B UBE4A 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G UBE2L3 UBE4A 23023127 pred GP G G G G GP G GP GP G GP G G G G GP GP G GP G G G GP GP GP G GP GP G UBE4A FBXL5 21836163 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G UBE4A RNF2 23023127 pred P P P GP P P P P P P P P P P P RING1 UBE4A 23023127 pred GP GP G G G GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP G GP GP G BMI1 UBE4A 23023127 pred P P P P P P P P P P P P P P P P P P P P UBE4A PUM1 21836163 pred GP GP G G G GP G G GP G GP GP GP GP G GP GP GP GP G GP GP GP G GP G GP GP G RNF4 UBE4A 23023127 pred GP G G G G GP G GP GP G GP G G G G G GP GP G G GP GP GP GP G G GP GP G DAP3 UBE4A 21836163 pred GP GP G G G GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP GP GP G GP GP G TTC3 UBE4A 23023127 pred P P P P P RNF103 UBE4A 23023127 pred G GP G G G GP G G GP G GP G GP GP G GP GP GP GP G G GP G G GP G GP GP G UBE4A UBE2F 23023127 pred GP GP G G G GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP G GP GP G UBE2G2 UBE4A 23023127 pred GP GP G G G GP G G GP G GP GP GP GP G GP GP G GP G GP GP G G GP G GP GP G UBE4A STUB1 23023127 pred GP GP G G G GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP G GP GP G UBE4A FBXO8 21836163 pred GP G G G G GP G G GP G G GP G G G GP GP G GP G GP GP GP G GP G GP GP G UBE4A TRAF6 23023127 pred GP GP G G G G G GP GP G GP GP GP G G GP G GP G G GP GP GP G GP G GP GP G ATP5J UBE4A 21836163 pred GP GP G G G GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP G GP GP G UBE4A RNF11 23023127 pred GP GP G G G GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP G GP GP G PSMC2 UBE4A 21836163 pred GP GP G G G GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP G GP GP G UBE4A TERF2IP 21836163 pred GP GP G G G GP G G GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP G GP GP G UBE4A FBXL7 21836163 pred G G G G G G G G GP G GP G G G G GP G G G G G G GP G GP G GP G G RNF13 UBE4A 23023127 pred GP GP G G G GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP G GP GP G UBE4A PTCD3 23023127 pred GP GP G G G GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP G GP GP G UBE4A ADRM1 21836163 pred GP GP G G G GP G G GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP G GP GP G STAU1 UBE4A 21836163 pred GP GP G G G GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP G GP GP G UBE4A RNF7 23023127 pred GP GP G G G GP G G GP G GP GP G GP G GP GP G GP G GP GP G G GP G GP GP G UBE4A UHRF2 23023127 pred GP GP G G G GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP G GP GP G UBE4A NHLRC1 23023127 pred UBE2H UBE4A 23023127 pred GP GP G G G GP G GP G G GP GP GP GP G GP GP GP GP G GP GP GP GP GP G GP GP G UBE4A NEDD8 21836163 pred GP GP G G G GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP G GP GP G PRDX6 UBE4A 21836163 pred GP GP G G G GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP G GP GP G UBA7 UBE4A 21836163 pred P P P P P P P P P P P P P P P P P UBE4A DZIP3 23023127 pred GP GP G G G GP G GP GP G GP G GP GP G GP GP GP GP G P GP GP GP GP G GP GP G IARS UBE4A 21836163 pred GP GP G G G GP G G GP G GP GP GP G G G GP G GP G GP G GP GP G G GP GP G REC8 UBE4A 21836163 pred GP GP G G G GP G G GP G G G GP GP G G GP GP GP G GP G GP GP G G G GP G UBE4A ICE1 21836163 pred GP GP G G G GP G GP GP G GP GP GP GP G G GP GP GP G GP G GP GP G G GP GP G BIRC2 UBE4A 23023127 pred GP GP G G G GP G GP GP G GP GP GP GP G GP GP G GP G GP G GP GP GP G GP GP G UBE2I UBE4A 23023127 pred GP GP G G G GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP G GP G GP GP G YWHAQ UBE4A 21836163 pred GP GP G G G GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP G GP G GP GP G VBP1 UBE4A 21836163 pred GP GP G G G GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP G GP GP G RPN1 UBE4A 21836163 pred G GP G G G GP G GP GP G G GP GP GP G GP GP G GP G GP GP GP GP GP G GP GP G CUL2 UBE4A 23023127 pred GP GP G G G GP G G GP G GP GP GP GP G G GP GP GP G GP GP GP G G G GP GP G UBE4A EFR3A 21836163 pred GP GP G G G GP G GP GP G GP GP GP G G GP GP GP GP G GP GP GP GP GP G GP GP G UBE4A CAND1 21836163 pred G GP G G G G G G GP G GP GP G G G GP G GP G G G G GP GP GP G G GP G GABARAPL2 UBE4A 21836163 pred G GP G G G GP G GP GP G GP G G G G GP GP G GP G G GP GP G GP G GP GP G UBE4A RLIM 23023127 pred GP GP G G G GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP G GP GP G UBE4A TTC14 23023127 pred GP GP G G G GP G GP GP G GP GP GP G G GP GP G GP G GP GP GP GP GP G GP GP G UBE4A RNF115 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PSMD4 UBE4A 21836163 pred GP GP G G G GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP G GP GP G UBE2C UBE4A 23023127 pred GP GP G G G GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP G GP GP G UBE4A UBE2V2 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G MFAP1 UBE4A 21836163 pred GP GP G G G GP G GP GP G GP GP GP GP G GP GP GP GP G GP G GP GP GP G GP GP G CAP1 UBE4A 21836163 pred GP GP G G G GP G G GP G GP GP GP GP G GP GP GP GP G GP GP GP G GP G GP GP G UBE2K UBE4A 23023127, 21836163 pred GP GP G G G GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP G GP GP G UBE4A SMAP1 23023127 pred GP GP G G G GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP G GP GP G UBE4A WDSUB1 23023127 pred G G G G G G G G G G GP G G G G G G G G G G G G G G G G GP G RNF8 UBE4A 23023127 pred GP GP G G G GP G GP GP G GP G G G G GP GP G GP G G G GP G GP G GP GP G UBE4A COPS8 21836163 pred G G G G G GP G GP G G G G GP G G G GP G G G G G G G G G G GP G RBX1 UBE4A 23023127 pred G G G G G GP G GP G G G G GP G G G GP G GP G GP GP G G G G G GP G UBE4A SMURF2 21836163 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G UBE4A RNF220 23023127 pred G GP G G G GP G G GP G GP GP GP G G G GP G GP G GP GP GP GP G G GP G G UBE4A UBE2T 23023127 pred G G G GP G GP P P P GP GP P GP P G GP P GP G PPP1CC UBE4A 21836163 pred GP GP G G G GP G GP GP G GP GP GP G G GP GP G GP G GP GP GP GP GP G GP GP G SRP19 UBE4A 21836163 pred GP GP G G G GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP G GP GP G CUL1 UBE4A 23023127 pred GP G G G G GP G GP GP G GP GP GP G G GP GP GP GP G GP GP GP GP GP G GP GP G UBE4A RBBP6 23023127 pred GP G G G G GP G GP GP G GP GP GP G G GP GP G G G GP G GP G GP G GP GP G UBE4A FBXL4 21836163 pred GP GP G G GP G GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP GP G GP P G UBE4A RNF135 23023127 pred GP GP G G G GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP G GP GP G UBE4A SYCP3 21836163 pred G G G G G G G GP UBE4A WWP1 21836163 pred GP GP G G G GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP G GP GP G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants P61077-3 Q14139 pull down 15611659 direct interaction X 2 P61077-3 Q14139 two hybrid 19690564 direct interaction X 2 Q7Z434-4 Q14139 affinity chromatography technology 21903422 physical association X 2 Q7Z434-4 Q14139 pull down 21903422 direct interaction X 2 P0CG48 Q14139 affinity chromatography technology 22505724 physical association X 2 P0CG48 Q14139 affinity chromatography technology 21963094 physical association X 2 P0CG48 Q14139 affinity chromatography technology 24816145 physical association X 2 P0CG48 Q14139 affinity chromatography technology 25147182 physical association X 2 P0CG48 Q14139 affinity chromatography technology 21139048 physical association X 2 P0CG48 Q14139 affinity chromatography technology 21890473 physical association X 2 P0CG48 Q14139 affinity chromatography technology 21906983 physical association X 2 O95997 Q14139 enzymatic study 15611659 direct interaction X 2 Q14139 Q92575 affinity chromatography technology 22119785 physical association X 2 Q14139 P62837 two hybrid 19690564 direct interaction X 2 Q14139 A0A024RA90 two hybrid 19690564 direct interaction X 2 Q14139 P55212 enzymatic study 11802788 direct interaction X 2 A0A024R1Q2 Q14139 affinity chromatography technology 21282530 physical association X 2 A0A087WW00 Q14139 two hybrid 19690564 direct interaction X 2 A0A024QZA8 Q14139 enzymatic study 24457997 direct interaction X 2 Q9BQE4 Q14139 affinity chromatography technology 22119785 physical association X 2 P10144 Q14139 enzymatic study 11802788 direct interaction X 2 Q14139 Q13239-2 affinity chromatography technology 24457997 physical association X 2 Q14139 Q13239-2 affinity chromatography technology 24457997 physical association X 2 Q14139 Q13239-2 pull down 24457997 direct interaction X 2 Q14139 O75365-3 affinity chromatography technology 17353931 physical association X 2 Q14139 tandem affinity purification 21282530 association C 16 Q7Z434 Q14139 anti tag coimmunoprecipitation 21903422 physical association X 2 Q14139 A0A024RA90 two hybrid array 19690564 physical association X 2 Q14139 P62837 two hybrid array 19690564 physical association X 2 Q14139 anti tag coimmunoprecipitation 21903422 association C 11 A0A024RDH2 Q14139 two hybrid array 19690564 physical association X 2 A0A024QZJ2 Q14139 two hybrid array 19690564 physical association X 2 O75365 Q14139 anti bait coimmunoprecipitation 17353931 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B VCP UBE4A MI:0493(in vivo) 15189447 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) - MI:0468(hprd) HPRD_31940 - - UBE2D3 UBE4A MI:0004(affinity chromatography technology)|MI:0018(two hybrid)|MI:0397(two hybrid array) 15611659,19690564 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(biogrid)|(intact) BIOGRID_225924|BIOGRID_123479|UniProt_102467 prey|bait|bait bait|prey|prey UBE2D1 UBE4A MI:0397(two hybrid array)|MI:0018(two hybrid) 19690564 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_102406|BIOGRID_123417 bait|bait prey|prey UBE2D2 UBE4A MI:0018(two hybrid)|MI:0397(two hybrid array) 19690564 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_123445|UniProt_102435 bait|bait prey|prey CBX7 UBE4A MI:0676(tandem affinity purification)|MI:0004(affinity chromatography technology) 21282530 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0914(association)|MI:0915(physical association) (intact)|(biogrid) UniProt_111847|BIOGRID_263012 bait|bait prey|prey GZMB UBE4A MI:0492(in vitro)|MI:0415(enzymatic study) 11802788 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) -|MI:0407(direct interaction) MI:0468(hprd)|(biogrid) HPRD_27868|BIOGRID_136447 -|bait -|prey UBE4A MAVS MI:0007(anti tag coimmunoprecipitation)|MI:0004(affinity chromatography technology)|MI:0007(anti tag coimmunoprecipitation)|MI:0004(affinity chromatography technology)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation) 21903422 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0914(association)|MI:0914(association) (intact)|(biogrid)|(intact)|(biogrid)|(intact)|(intact) UniProt_115808|BIOGRID_155945|UniProt_172544|BIOGRID_155632|UniProt_115769|UniProt_172511 bait|prey|bait|prey|prey|prey prey|bait|prey|bait|bait|bait CASP6 UBE4A MI:0415(enzymatic study) 11802788 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_136446 bait prey UBE4A ELAVL1 MI:0096(pull down) 19322201 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_187757 prey bait UBE4A UBE2D4 MI:0018(two hybrid)|MI:0397(two hybrid array) 19690564 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_123511|UniProt_102501 prey|prey bait|bait PTP4A3 UBE4A MI:0006(anti bait coimmunoprecipitation)|MI:0004(affinity chromatography technology) 17353931 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (intact)|(biogrid) UniProt_147519|BIOGRID_83519 bait|bait prey|prey UBC UBE4A MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 21139048,21890473,21906983,21963094,22505724 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid) BIOGRID_170730|BIOGRID_265261|BIOGRID_179957|BIOGRID_225524|BIOGRID_173942 bait|bait|bait|bait|bait prey|prey|prey|prey|prey PTTG1 UBE4A MI:0004(affinity chromatography technology) 15611659 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_140055 prey bait

PPI - HINT Gene A Gene B PMID Method Quality B4GALT3 UBE4A 26186194 0004 HT PTP4A3 UBE4A 17353931,17353931 0006,0004 HT VAPB UBE4A 26186194 0004 HT FOXL2 UBE4A 25609649,25609649 0676,0004 HT IL9R UBE4A 26186194 0004 HT FOXL1 UBE4A 25609649,25609649 0676,0004 HT UBE4A FOXI2 25609649,25609649 0676,0004 HT UBE4A PARP16 26186194 0004 HT UBE4A UBXN4 22119785,26186194,26389662 0004,0004,0004 LC,HT UBE4A FOXB1 25609649,25609649 0676,0004 HT UBE4A FOXQ1 25609649,25609649 0676,0004 HT B4GALT3 UBE4A 26186194 0004 HT PTP4A3 UBE4A 17353931,17353931 0006,0004 HT VAPB UBE4A 26186194 0004 HT FOXL2 UBE4A 25609649,25609649 0676,0004 HT IL9R UBE4A 26186194 0004 HT FOXL1 UBE4A 25609649,25609649 0676,0004 HT UBE4A FOXI2 25609649,25609649 0676,0004 HT UBE4A PARP16 26186194 0004 HT UBE4A UBXN4 26186194 0004 HT UBE4A FOXB1 25609649,25609649 0676,0004 HT UBE4A FOXQ1 25609649,25609649 0676,0004 HT UBE4A UBXN4 22119785,26389662 0004,0004 LC PTTG1 UBE4A 15611659 0415 LC GZMB UBE4A 11802788 0415 LC EPHA2 UBE4A 24457997 0415 LC UBE2D1 UBE4A 19690564,19690564 0397,0018 HT CASP6 UBE4A 11802788 0415 LC UBE2D3 UBE4A 19690564,19690564 0397,0018 HT UBE2D2 UBE4A 19690564,19690564 0397,0018 HT UBE4A Q67BC3 11802788 0415 LC UBE4A UBE2D4 19690564,19690564 0397,0018 HT

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q8N5Y8 Q14139 PARP16 UBE4A 0.126 26186194 Q14139 O60512 UBE4A B4GALT3 0.126 26186194 Q14139 P10144 UBE4A GZMB 0.309 11802788 Q14139 O95292 UBE4A VAPB 0.126 26186194 Q14139 P04629 UBE4A NTRK1 0.126 25921289 Q14139 O95931 UBE4A CBX7 0.126 21282530 Q9Y2X8 Q14139 UBE2D4 UBE4A 0.286 19690564 Q92551 Q14139 IP6K1 UBE4A 0.236 unassigned1304 Q99853 Q14139 FOXB1 UBE4A 0.236 25609649 Q9C009 Q14139 FOXQ1 UBE4A 0.236 25609649 Q14139 Q12952 UBE4A FOXL1 0.236 25609649 Q6ZQN5 Q14139 FOXI2 UBE4A 0.236 25609649 Q14139 P51668 UBE4A UBE2D1 0.286 19690564 Q14139 P58012 UBE4A FOXL2 0.236 25609649 Q7Z434 Q14139 MAVS UBE4A 0.454 21903422 Q9BQE4 Q14139 VIMP UBE4A 0.126 22119785 Q14139 P62837 UBE4A UBE2D2 0.286 19690564 Q14139 O75365 UBE4A PTP4A3 0.236 17353931 Q14139 O95997 UBE4A PTTG1 0.309 15611659 Q14139 P29317 UBE4A EPHA2 0.309 24457997 Q14139 P61077 UBE4A UBE2D3 0.376 19690564 Q14139 Q13239 UBE4A SLA 0.569 24457997 Q92575 Q14139 UBXN4 UBE4A 0.416 22119785,26186194,26389662 Q14139 Q01113 UBE4A IL9R 0.126 26186194 Q15717 Q14139 ELAVL1 UBE4A 0.126 19322201 Q14139 P55212 UBE4A CASP6 0.309 11802788

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 B4GALT3 UBE4A MI:0045 experimental interaction detection MI:0461 interaction database PTP4A3 UBE4A MI:0045 experimental interaction detection MI:0461 interaction database VAPB UBE4A MI:0045 experimental interaction detection MI:0461 interaction database CBX7 UBE4A MI:0045 experimental interaction detection MI:0461 interaction database PTTG1 UBE4A MI:0045 experimental interaction detection MI:0461 interaction database NTRK1 UBE4A MI:0045 experimental interaction detection MI:0461 interaction database UBC UBE4A MI:0045 experimental interaction detection MI:0461 interaction database GZMB UBE4A MI:0045 experimental interaction detection MI:0461 interaction database TAF1 UBE4A MI:0045 experimental interaction detection MI:0461 interaction database EPHA2 UBE4A MI:0045 experimental interaction detection MI:0461 interaction database UBE2D1 UBE4A MI:0045 experimental interaction detection MI:0461 interaction database VCP UBE4A MI:0362 inference MI:0461 interaction database CASP6 UBE4A MI:0045 experimental interaction detection MI:0461 interaction database FOXL2 UBE4A MI:0045 experimental interaction detection MI:0461 interaction database UBE2D3 UBE4A MI:0045 experimental interaction detection MI:0461 interaction database UBE2D2 UBE4A MI:0045 experimental interaction detection MI:0461 interaction database IL9R UBE4A MI:0045 experimental interaction detection MI:0461 interaction database FOXL1 UBE4A MI:0045 experimental interaction detection MI:0461 interaction database SLA UBE4A MI:0045 experimental interaction detection MI:0461 interaction database UBE4A ITPR1 MI:0362 inference MI:0461 interaction database UBE4A ELAVL1 MI:0045 experimental interaction detection MI:0461 interaction database UBE4A FOXI2 MI:0045 experimental interaction detection MI:0461 interaction database UBE4A MAVS MI:0045 experimental interaction detection MI:0461 interaction database UBE4A PARP16 MI:0045 experimental interaction detection MI:0461 interaction database UBE4A UBXN4 MI:0045 experimental interaction detection MI:0461 interaction database UBE4A DNAJC7 MI:0362 inference MI:0461 interaction database UBE4A FOXB1 MI:0045 experimental interaction detection MI:0461 interaction database UBE4A VIMP MI:0045 experimental interaction detection MI:0461 interaction database UBE4A FOXQ1 MI:0045 experimental interaction detection MI:0461 interaction database UBE4A UBE2D4 MI:0045 experimental interaction detection MI:0461 interaction database