PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus SENP6 RUVBL2 20603076,16699503 biogrid exp GP GP G G G GP G GP GP G GP G GP G G G GP GP GP G GP GP G GP G G GP GP G COPS5 SENP6 21145461 biogrid exp GP GP G G G GP G GP GP G GP G GP G G G GP GP GP G GP GP G GP G G GP GP G KAT5 SENP6 17704809 biogrid exp GP GP G G G GP G GP GP G GP G GP G G G GP GP GP G GP GP G GP G G GP GP G SENP6 SCHIP1 20195357 intact exp P P P P P P P P P P P P P SUMO1 SENP6 10799485,21148299 hprd,biogrid exp GP GP G G G GP G GP GP G GP G GP G G G GP GP GP G GP GP G GP G G GP GP G SP1 SENP6 20195357 biogrid,intact exp GP GP G G G GP G GP GP G GP G GP G G G GP GP GP G GP GP G GP G G GP GP G SUMO2 SENP6 21148299,17000875 biogrid exp GP GP G G G GP G GP GP G GP G GP G G G GP GP GP G GP GP G GP G G GP GP G FHL3 SENP6 26186194 biogrid exp GP G G G G P G G GP P G G G G GP GP GP P GP GP G G GP GP G ARNT SENP6 12354770 hprd exp GP GP G G G GP G G GP G GP G GP G G G GP GP GP G GP GP G GP G G GP GP G LMNA SENP6 22412018 biogrid exp GP GP G G G GP G GP GP G GP G GP G G G GP GP GP G GP GP G GP G G GP GP G PLA2G2A SENP6 22118674 biogrid exp GP GP G G P G GP GP P G G G G G GP GP GP GP GP G GP G G GP GP G SENP6 IKBKG ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G RARA SENP6 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G SUMO3 SENP6 ortho GP GP G G G GP G GP GP G GP G GP G G G GP GP GP G GP GP G GP G G GP GP G ZNF292 SENP6 25402006 pred G G G G G GP G G GP G GP G G G G G GP G G G GP G G GP G G G G G PNISR SENP6 25402006 pred GP GP G G G GP G GP GP G GP G G G G G GP G GP G G GP G GP G G GP GP G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants P08047 Q9GZR1 pull down 20195357 direct interaction X 2 Q9GZR1 P02545-5 proximity labelling technology 22412018 physical association X 2 P0CG48 Q9GZR1 affinity chromatography technology 24816145 physical association X 2 A0A024RA96 Q9GZR1 enzymatic study 22118674 direct interaction X 2 Q92993-4 Q9GZR1 affinity chromatography technology 17704809 physical association X 2 Q92993-4 Q9GZR1 affinity chromatography technology 17704809 physical association X 2 Q92993-4 Q9GZR1 affinity chromatography technology 17704809 physical association X 2 P61956-2 Q9GZR1 pull down 17000875 direct interaction X 2 P61956-2 Q9GZR1 enzymatic study 21148299 direct interaction X 2 P61956-2 Q9GZR1 affinity chromatography technology 21693764 physical association X 2 Q9Y230 Q9GZR1 affinity chromatography technology 16699503 physical association X 2 Q9Y230 Q9GZR1 affinity chromatography technology 20603076 physical association X 2 A0A024R7W9 Q9GZR1 affinity chromatography technology 21145461 physical association X 2 A0A024R3Z2 Q9GZR1 enzymatic study 21148299 direct interaction X 2 P08047 Q9GZR1 display technology 20195357 physical association X 2 Q5NHN4 Q9GZR1 two hybrid pooling approach 20711500 physical association X 2 Q9P0W5 Q9GZR1 display technology 20195357 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B ARNT SENP6 MI:0492(in vitro) 12354770 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) - MI:0468(hprd) HPRD_29812 - - SP1 SENP6 MI:0034(display technology)|MI:0096(pull down) 20195357 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_104418|BIOGRID_290426 bait|bait prey|prey PLA2G2A SENP6 MI:0415(enzymatic study) 22118674 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_160295 prey bait SUMO2 SENP6 MI:0004(affinity chromatography technology)|MI:0415(enzymatic study)|MI:0428(imaging technique) 17000875,21148299,21693764 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction)|MI:0407(direct interaction) (biogrid)|(biogrid)|(biogrid) BIOGRID_166006|BIOGRID_164597|BIOGRID_201396 bait|prey|bait prey|bait|prey KAT5 SENP6 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 17704809 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid) BIOGRID_185182|BIOGRID_185192|BIOGRID_185188 bait|prey|bait prey|bait|prey COPS5 SENP6 MI:0004(affinity chromatography technology) 21145461 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_205551 bait prey LMNA SENP6 - 22412018 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_280450 bait prey PML SENP6 MI:0415(enzymatic study) 21148299 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_164599 prey bait SENP6 SCHIP1 MI:0034(display technology) 20195357 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (intact) UniProt_104403 prey bait SENP6 RUVBL2 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 16699503,20603076 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_129989|BIOGRID_138696 prey|prey bait|bait SUMO1 SENP6 MI:0415(enzymatic study)|MI:0492(in vitro) 10799485,21148299 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|- (biogrid)|MI:0468(hprd) BIOGRID_164598|HPRD_10058 prey|- bait|-

PPI - HINT Gene A Gene B PMID Method Quality FHL3 SENP6 26186194 0004 HT COPS5 SENP6 21145461 0004 HT SENP6 RUVBL2 20603076,16699503 0004,0004 LC FHL3 SENP6 26186194 0004 HT COPS5 SENP6 21145461 0004 HT SENP6 RUVBL2 20603076,16699503 0004,0004 LC SP1 SENP6 20195357,20195357 0034,0096 LC PLA2G2A SENP6 22118674 0415 LC PML SENP6 21148299 0415 LC SUMO2 SENP6 21148299 0415 LC SUMO1 SENP6 21148299 0415 LC SENP6 SCHIP1 20195357 0034 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q9GZR1 P61956 SENP6 SUMO2 0.523 17000875,21148299 Q9GZR1 P14555 SENP6 PLA2G2A 0.309 22118674 Q9GZR1 P63165 SENP6 SUMO1 0.309 21148299 Q9GZR1 Q5NHN4 SENP6 GLGB 0.126 20711500 Q9GZR1 P02545 SENP6 LMNA 0.126 22412018 Q9GZR1 P08047 SENP6 SP1 0.286 20195357 Q9Y230 Q9GZR1 RUVBL2 SENP6 0.376 20603076,16699503 Q9GZR1 Q6IRU7 SENP6 CEP78 0.236 26496610 Q9GZR1 P63330 SENP6 PPP2CA 0.236 26496610 Q9GZR1 Q92905 SENP6 COPS5 0.126 21145461 Q9GZR1 Q92993 SENP6 KAT5 0.376 17704809 Q9P0W5 Q9GZR1 SCHIP1 SENP6 0.126 20195357 Q9GZR1 Q13643 SENP6 FHL3 0.126 26186194

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 LMNA SENP6 MI:0045 experimental interaction detection MI:0461 interaction database SP1 SENP6 MI:0045 experimental interaction detection MI:0461 interaction database UBC SENP6 MI:0045 experimental interaction detection MI:0461 interaction database RARA SENP6 MI:0362 inference MI:0461 interaction database PLA2G2A SENP6 MI:0045 experimental interaction detection MI:0461 interaction database SUMO3 SENP6 MI:0362 inference MI:0461 interaction database SUMO2 SENP6 MI:0045 experimental interaction detection MI:0461 interaction database SUMO1 SENP6 MI:0045 experimental interaction detection MI:0461 interaction database PPP2CA SENP6 MI:0362 inference MI:0461 interaction database FHL3 SENP6 MI:0045 experimental interaction detection MI:0461 interaction database CEP78 SENP6 MI:0362 inference MI:0461 interaction database SUMO4 SENP6 MI:0362 inference MI:0461 interaction database COPS5 SENP6 MI:0045 experimental interaction detection MI:0461 interaction database KAT5 SENP6 MI:0045 experimental interaction detection MI:0461 interaction database SENP6 SCHIP1 MI:0045 experimental interaction detection MI:0461 interaction database SENP6 RUVBL2 MI:0045 experimental interaction detection MI:0461 interaction database SENP6 IKBKG MI:0362 inference MI:0461 interaction database