PTM - dbPAF Gene Name UniProt ID Position Type Species SENP6; KIAA0797; SSP1; SUSP1; FKSG6 Q9GZR1 100 T Homo sapiens(Human) SENP6; KIAA0797; SSP1; SUSP1; FKSG6 Q9GZR1 1111 S Homo sapiens(Human) SENP6; KIAA0797; SSP1; SUSP1; FKSG6 Q9GZR1 214 Y Homo sapiens(Human) SENP6; KIAA0797; SSP1; SUSP1; FKSG6 Q9GZR1 217 T Homo sapiens(Human) SENP6; KIAA0797; SSP1; SUSP1; FKSG6 Q9GZR1 221 S Homo sapiens(Human) SENP6; KIAA0797; SSP1; SUSP1; FKSG6 Q9GZR1 224 S Homo sapiens(Human) SENP6; KIAA0797; SSP1; SUSP1; FKSG6 Q9GZR1 323 T Homo sapiens(Human) SENP6; KIAA0797; SSP1; SUSP1; FKSG6 Q9GZR1 324 S Homo sapiens(Human) SENP6; KIAA0797; SSP1; SUSP1; FKSG6 Q9GZR1 326 S Homo sapiens(Human) SENP6; KIAA0797; SSP1; SUSP1; FKSG6 Q9GZR1 335 S Homo sapiens(Human) SENP6; KIAA0797; SSP1; SUSP1; FKSG6 Q9GZR1 336 S Homo sapiens(Human) SENP6; KIAA0797; SSP1; SUSP1; FKSG6 Q9GZR1 35 S Homo sapiens(Human) SENP6; KIAA0797; SSP1; SUSP1; FKSG6 Q9GZR1 350 S Homo sapiens(Human) SENP6; KIAA0797; SSP1; SUSP1; FKSG6 Q9GZR1 352 S Homo sapiens(Human) SENP6; KIAA0797; SSP1; SUSP1; FKSG6 Q9GZR1 358 S Homo sapiens(Human) SENP6; KIAA0797; SSP1; SUSP1; FKSG6 Q9GZR1 361 S Homo sapiens(Human) SENP6; KIAA0797; SSP1; SUSP1; FKSG6 Q9GZR1 362 S Homo sapiens(Human) SENP6; KIAA0797; SSP1; SUSP1; FKSG6 Q9GZR1 398 T Homo sapiens(Human) SENP6; KIAA0797; SSP1; SUSP1; FKSG6 Q9GZR1 412 S Homo sapiens(Human) SENP6; KIAA0797; SSP1; SUSP1; FKSG6 Q9GZR1 416 T Homo sapiens(Human) SENP6; KIAA0797; SSP1; SUSP1; FKSG6 Q9GZR1 42 S Homo sapiens(Human) SENP6; KIAA0797; SSP1; SUSP1; FKSG6 Q9GZR1 55 S Homo sapiens(Human) SENP6; KIAA0797; SSP1; SUSP1; FKSG6 Q9GZR1 577 S Homo sapiens(Human) SENP6; KIAA0797; SSP1; SUSP1; FKSG6 Q9GZR1 599 Y Homo sapiens(Human) SENP6; KIAA0797; SSP1; SUSP1; FKSG6 Q9GZR1 6 S Homo sapiens(Human) SENP6; KIAA0797; SSP1; SUSP1; FKSG6 Q9GZR1 606 S Homo sapiens(Human) SENP6; KIAA0797; SSP1; SUSP1; FKSG6 Q9GZR1 819 S Homo sapiens(Human) SENP6; KIAA0797; SSP1; SUSP1; FKSG6 Q9GZR1 869 S Homo sapiens(Human) SENP6; KIAA0797; SSP1; SUSP1; FKSG6 Q9GZR1 9 S Homo sapiens(Human) SENP6; KIAA0797; SSP1; SUSP1; FKSG6 Q9GZR1 915 Y Homo sapiens(Human) SENP6; KIAA0797; SSP1; SUSP1; FKSG6 Q9GZR1 916 S Homo sapiens(Human) SENP6; KIAA0797; SSP1; SUSP1; FKSG6 Q9GZR1 919 S Homo sapiens(Human) SENP6; KIAA0797; SSP1; SUSP1; FKSG6 Q9GZR1 985 S Homo sapiens(Human)

PTM - PhosphositePlus UniProt ID MOD_RSD Type SITE_+/-7_AA Q9GZR1 K99-m1 Methylation RNKSESFktLkGNPI Q9GZR1 K102-m1 Methylation SESFktLkGNPIGLN Q9GZR1 S6-p Phosphorylation __MAAGKsGGsAGEI Q9GZR1 S9-p Phosphorylation AAGKsGGsAGEITFL Q9GZR1 S22-p Phosphorylation FLEALARsESKRDGG Q9GZR1 S35-p Phosphorylation GGFKNNWsFDHEEEs Q9GZR1 S42-p Phosphorylation sFDHEEEsEGDTDKD Q9GZR1 S55-p Phosphorylation KDGTNLLsVDEDEDS Q9GZR1 T100-p Phosphorylation NKSESFktLkGNPIG Q9GZR1 Y214-p Phosphorylation QKRHCSTyQPtPPLs Q9GZR1 T217-p Phosphorylation HCSTyQPtPPLsPAs Q9GZR1 S221-p Phosphorylation yQPtPPLsPAsKKCL Q9GZR1 S224-p Phosphorylation tPPLsPAsKKCLTHL Q9GZR1 T323-p Phosphorylation TNLKERKtSLSDLND Q9GZR1 S335-p Phosphorylation LNDPIILssDDDDDN Q9GZR1 S336-p Phosphorylation NDPIILssDDDDDND Q9GZR1 T345-p Phosphorylation DDDDNDRtNRREsIs Q9GZR1 S350-p Phosphorylation DRtNRREsIsPQPAD Q9GZR1 S352-p Phosphorylation tNRREsIsPQPADSA Q9GZR1 S361-p Phosphorylation QPADSACssPAPSTG Q9GZR1 S362-p Phosphorylation PADSACssPAPSTGK Q9GZR1 T398-p Phosphorylation DSELNTVtLPRKARM Q9GZR1 S412-p Phosphorylation MkDQFGNsIINtPLk Q9GZR1 T416-p Phosphorylation FGNsIINtPLkRRKV Q9GZR1 S577-p Phosphorylation IGIKNNIsNFFAKIP Q9GZR1 Y599-p Phosphorylation LVACTRTyEESIKGs Q9GZR1 S606-p Phosphorylation yEESIKGsCGQKENK Q9GZR1 S819-p Phosphorylation ESCSQNSsAKPVIKK Q9GZR1 S869-p Phosphorylation KKINHTAsENEEFNK Q9GZR1 S916-p Phosphorylation SKIRLNYsDEsPEAG Q9GZR1 S919-p Phosphorylation RLNYsDEsPEAGKML Q9GZR1 S985-p Phosphorylation SLRGPSRsNVVKILR Q9GZR1 S1111-p Phosphorylation EQYVNSIsD______ Q9GZR1 K189-sm Sumoylation GVERIMKkTEESESQ Q9GZR1 K274-sm Sumoylation NTGLTTKkFYGNNVE Q9GZR1 K406-sm Sumoylation LPRKARMkDQFGNsI Q9GZR1 K419-sm Sumoylation sIINtPLkRRKVFSQ Q9GZR1 K1086-ub Ubiquitination QEDQSKEkRKHKDTY

PTM - dbPTM UniProt ID Position Code Type Resources References Q9GZR1 335 S Phosphorylation Swiss-Prot 1010711 17081983;18669648 Q9GZR1 336 S Phosphorylation Swiss-Prot 1010711 17081983;18669648 Q9GZR1 350 S Phosphorylation Swiss-Prot 1010711 18669648 Q9GZR1 352 S Phosphorylation Swiss-Prot 1010711 18669648;19413330 Q9GZR1 361 S Phosphorylation Swiss-Prot 1010711 18669648 Q9GZR1 919 S Phosphorylation Swiss-Prot 1010711 15302935;19690332 Q9GZR1 335 S Phosphorylation PhosphoELM.10011 18669648 Q9GZR1 336 S Phosphorylation PhosphoELM.10011 18669648 Q9GZR1 350 S Phosphorylation PhosphoELM.10011 18669648 Q9GZR1 352 S Phosphorylation PhosphoELM.10011 18669648 Q9GZR1 361 S Phosphorylation PhosphoELM.10011 18669648 Q9GZR1 919 S Phosphorylation PhosphoELM.10011 15302935 Q9GZR1 335 S Phosphorylation Phosphositeplus.1010730 18669648;20363803;20393185;22115753 Q9GZR1 336 S Phosphorylation Phosphositeplus.1010730 18669648;20363803;20393185;22115753 Q9GZR1 35 S Phosphorylation Phosphositeplus.1010730 21406692 Q9GZR1 350 S Phosphorylation Phosphositeplus.1010730 18669648 Q9GZR1 352 S Phosphorylation Phosphositeplus.1010730 15302935;18669648;19664994 Q9GZR1 42 S Phosphorylation Phosphositeplus.1010730 21406692 Q9GZR1 919 S Phosphorylation Phosphositeplus.1010730 15302935;19690332;20363803;22115753 Q9GZR1 42 S Phosphorylation HPRD 9.0 19651622 Q9GZR1 324 S Phosphorylation HPRD 9.0 17322306 Q9GZR1 326 S Phosphorylation HPRD 9.0 17322306,18452278 Q9GZR1 335 S Phosphorylation HPRD 9.0 17081983,18669648,19651622,18452278 Q9GZR1 336 S Phosphorylation HPRD 9.0 17081983,18669648,19651622,18452278 Q9GZR1 350 S Phosphorylation HPRD 9.0 18669648 Q9GZR1 352 S Phosphorylation HPRD 9.0 18669648,19413330,19664994 Q9GZR1 361 S Phosphorylation HPRD 9.0 18669648 Q9GZR1 919 S Phosphorylation HPRD 9.0 15302935,19651622 Q9GZR1 323 T Phosphorylation HPRD 9.0 17322306,18452278 Q9GZR1 335 S Phosphorylation SysPTM 1.1 18669648;17081983 Q9GZR1 336 S Phosphorylation SysPTM 1.1 18669648;17081983 Q9GZR1 350 S Phosphorylation SysPTM 1.1 18669648 Q9GZR1 352 S Phosphorylation SysPTM 1.1 18669648 Q9GZR1 361 S Phosphorylation SysPTM 1.1 18669648 Q9GZR1 919 S Phosphorylation SysPTM 1.1 15302935

PTM - HPRD Symbol Position Code Type References SENP6 323 T Phosphorylation 17322306,18452278 SENP6 324 S Phosphorylation 17322306 SENP6 326 S Phosphorylation 17322306,18452278 SENP6 335 S Phosphorylation 17081983,18669648,19651622,18452278 SENP6 336 S Phosphorylation 17081983,18669648,19651622,18452278 SENP6 350 S Phosphorylation 18669648 SENP6 352 S Phosphorylation 18669648,19413330,19664994 SENP6 361 S Phosphorylation 18669648 SENP6 42 S Phosphorylation 19651622 SENP6 919 S Phosphorylation 15302935,19651622

PTM - Phospho.ELM UniProt Position Code PMIDs Kinase Source Type Q9GZR1 919 S 15302935 HTP Phosphorylation Q9GZR1 352 S 18669648 HTP Phosphorylation Q9GZR1 350 S 18669648 HTP Phosphorylation Q9GZR1 361 S 18669648 HTP Phosphorylation Q9GZR1 336 S 18669648 HTP Phosphorylation Q9GZR1 335 S 18669648 HTP Phosphorylation

PTM - UniProt UniProt ID Position Type PMIDs Q9GZR1 42 Phosphoserine 21406692 Q9GZR1 335 Phosphoserine 18669648 Q9GZR1 336 Phosphoserine 18669648 Q9GZR1 350 Phosphoserine 18669648 Q9GZR1 352 Phosphoserine 18669648 Q9GZR1 416 Phosphothreonine 23186163 Q9GZR1 919 Phosphoserine 23186163 Q9GZR1 1111 Phosphoserine 23186163

PTM - PHOSIDA Symbol Accession Code Position Surrounding Sequence Type SENP6 IPI00023586 S 336 NDPIILpSSDDDDD phosphorylation SENP6 IPI00023586 S 337 DPIILSpSDDDDDN phosphorylation

PTM - BioGRID Entrez Gene BioGRID ID Position Code Type PMIDs 26054 117517 - K Sumoylation 21693764 26054 117517 - K Ubiquitination 24816145