PTM - CPLM Gene Name UniProt ID Type Position Code UBE3A; E6AP; EPVE6AP; HPVE6A Q05086 Ubiquitination 71 K UBE3A; E6AP; EPVE6AP; HPVE6A Q05086 Ubiquitination 30 K UBE3A; E6AP; EPVE6AP; HPVE6A Q05086 Ubiquitination 77 K UBE3A; E6AP; EPVE6AP; HPVE6A Q05086 Ubiquitination 123 K UBE3A; E6AP; EPVE6AP; HPVE6A Q05086 Ubiquitination 311 K UBE3A; E6AP; EPVE6AP; HPVE6A Q05086 Ubiquitination 323 K UBE3A; E6AP; EPVE6AP; HPVE6A Q05086 Ubiquitination 330 K UBE3A; E6AP; EPVE6AP; HPVE6A Q05086 Ubiquitination 350 K UBE3A; E6AP; EPVE6AP; HPVE6A Q05086 Ubiquitination 373 K UBE3A; E6AP; EPVE6AP; HPVE6A Q05086 Ubiquitination 468 K UBE3A; E6AP; EPVE6AP; HPVE6A Q05086 Ubiquitination 711 K UBE3A; E6AP; EPVE6AP; HPVE6A Q05086 Ubiquitination 724 K UBE3A; E6AP; EPVE6AP; HPVE6A Q05086 Ubiquitination 728 K UBE3A; E6AP; EPVE6AP; HPVE6A Q05086 Ubiquitination 132 K UBE3A; E6AP; EPVE6AP; HPVE6A Q05086 Ubiquitination 870 K UBE3A; E6AP; EPVE6AP; HPVE6A Q05086 Ubiquitination 101 K UBE3A; E6AP; EPVE6AP; HPVE6A Q05086 Ubiquitination 226 K UBE3A; E6AP; EPVE6AP; HPVE6A Q05086 Ubiquitination 864 K UBE3A; E6AP; EPVE6AP; HPVE6A Q05086 Ubiquitination 435 K UBE3A; E6AP; EPVE6AP; HPVE6A Q05086 Ubiquitination 315 K UBE3A; E6AP; EPVE6AP; HPVE6A Q05086 Ubiquitination 802 K UBE3A; E6AP; EPVE6AP; HPVE6A Q05086 Ubiquitination 112 K UBE3A; E6AP; EPVE6AP; HPVE6A Q05086 Ubiquitination 81 K UBE3A; E6AP; EPVE6AP; HPVE6A Q05086 Ubiquitination 552 K UBE3A; E6AP; EPVE6AP; HPVE6A Q05086 Ubiquitination 90 K UBE3A; E6AP; EPVE6AP; HPVE6A Q05086 Ubiquitination 822 K UBE3A; E6AP; EPVE6AP; HPVE6A Q05086 Ubiquitination 702 K UBE3A; E6AP; EPVE6AP; HPVE6A Q05086 Ubiquitination 421 K UBE3A; E6AP; EPVE6AP; HPVE6A Q05086 Ubiquitination 553 K UBE3A; E6AP; EPVE6AP; HPVE6A Q05086 Ubiquitination 824 K UBE3A; E6AP; EPVE6AP; HPVE6A Q05086 Ubiquitination 857 K UBE3A; E6AP; EPVE6AP; HPVE6A Q05086 Ubiquitination 829 K UBE3A; E6AP; EPVE6AP; HPVE6A Q05086 Ubiquitination 731 K UBE3A; E6AP; EPVE6AP; HPVE6A Q05086 Ubiquitination 474 K UBE3A; E6AP; EPVE6AP; HPVE6A Q05086 Ubiquitination 184 K UBE3A; E6AP; EPVE6AP; HPVE6A Q05086 Ubiquitination 441 K

PTM - dbPAF Gene Name UniProt ID Position Type Species UBE3A; E6AP; EPVE6AP; HPVE6A Q05086 100 S Homo sapiens(Human) UBE3A; E6AP; EPVE6AP; HPVE6A Q05086 109 S Homo sapiens(Human) UBE3A; E6AP; EPVE6AP; HPVE6A Q05086 127 Y Homo sapiens(Human) UBE3A; E6AP; EPVE6AP; HPVE6A Q05086 158 S Homo sapiens(Human) UBE3A; E6AP; EPVE6AP; HPVE6A Q05086 159 S Homo sapiens(Human) UBE3A; E6AP; EPVE6AP; HPVE6A Q05086 199 S Homo sapiens(Human) UBE3A; E6AP; EPVE6AP; HPVE6A Q05086 217 S Homo sapiens(Human) UBE3A; E6AP; EPVE6AP; HPVE6A Q05086 218 S Homo sapiens(Human) UBE3A; E6AP; EPVE6AP; HPVE6A Q05086 22 S Homo sapiens(Human) UBE3A; E6AP; EPVE6AP; HPVE6A Q05086 342 T Homo sapiens(Human) UBE3A; E6AP; EPVE6AP; HPVE6A Q05086 349 Y Homo sapiens(Human) UBE3A; E6AP; EPVE6AP; HPVE6A Q05086 465 T Homo sapiens(Human) UBE3A; E6AP; EPVE6AP; HPVE6A Q05086 471 T Homo sapiens(Human) UBE3A; E6AP; EPVE6AP; HPVE6A Q05086 479 T Homo sapiens(Human) UBE3A; E6AP; EPVE6AP; HPVE6A Q05086 508 T Homo sapiens(Human) UBE3A; E6AP; EPVE6AP; HPVE6A Q05086 511 Y Homo sapiens(Human) UBE3A; E6AP; EPVE6AP; HPVE6A Q05086 512 S Homo sapiens(Human) UBE3A; E6AP; EPVE6AP; HPVE6A Q05086 720 Y Homo sapiens(Human) UBE3A; E6AP; EPVE6AP; HPVE6A Q05086 96 Y Homo sapiens(Human)

PTM - PhosphositePlus UniProt ID MOD_RSD Type SITE_+/-7_AA Q05086 R294-m1 Methylation FIIVMENrNLHSPEY Q05086 S93-p Phosphorylation HPSKkGAsSAyLENs Q05086 Y96-p Phosphorylation KkGAsSAyLENskGA Q05086 S100-p Phosphorylation sSAyLENskGAPNNS Q05086 Y127-p Phosphorylation IDFkDVTyLTEEkVY Q05086 S158-p Phosphorylation RVIGRVFssAEALVQ Q05086 S159-p Phosphorylation VIGRVFssAEALVQS Q05086 S199-p Phosphorylation EKEKAACsAAAMEED Q05086 S207-p Phosphorylation AAAMEEDsEASSSRI Q05086 S217-p Phosphorylation SSSRIGDssQGDNNL Q05086 S218-p Phosphorylation SSRIGDssQGDNNLQ Q05086 T342-p Phosphorylation QIRRMMEtFQQLITy Q05086 Y349-p Phosphorylation tFQQLITykVISNEF Q05086 T465-p Phosphorylation LEMDKDYtFFkVEtE Q05086 T471-p Phosphorylation YtFFkVEtENKFSFM Q05086 T479-p Phosphorylation ENKFSFMtCPFILNA Q05086 Y511-p Phosphorylation ERRITVLysLVQGQQ Q05086 S512-p Phosphorylation RRITVLysLVQGQQL Q05086 Y720-p Phosphorylation FVNLYSDyILNkSVE Q05086 K30-ub Ubiquitination RMKRAAAkHLIERYY Q05086 K71-ub Ubiquitination DNNAAAIkALELYkI Q05086 K77-ub Ubiquitination IkALELYkINAKLCD Q05086 K90-ub Ubiquitination CDPHPSKkGAsSAyL Q05086 K101-ub Ubiquitination SAyLENskGAPNNSC Q05086 K123-ub Ubiquitination KGARIDFkDVTyLTE Q05086 K132-ub Ubiquitination VTyLTEEkVYEILEL Q05086 K184-ub Ubiquitination ELKSLQAkDEDKDED Q05086 K226-ub Ubiquitination QGDNNLQkLGPDDVS Q05086 K311-ub Ubiquitination MALPLFCkAMSkLPL Q05086 K315-ub Ubiquitination LFCkAMSkLPLAAQG Q05086 K323-ub Ubiquitination LPLAAQGkLIRLWSk Q05086 K330-ub Ubiquitination kLIRLWSkYNADQIR Q05086 K350-ub Ubiquitination FQQLITykVISNEFN Q05086 K373-ub Ubiquitination DAIVAASkCLKMVYY Q05086 K421-ub Ubiquitination GEERRNKkGPRVDPL Q05086 K435-ub Ubiquitination LETELGVkTLDCRKP Q05086 K468-ub Ubiquitination DKDYtFFkVEtENKF Q05086 K552-ub Ubiquitination MENPADLkkQLYVEF Q05086 K553-ub Ubiquitination ENPADLkkQLYVEFE Q05086 K702-ub Ubiquitination DLKENGDkIPITNEN Q05086 K711-ub Ubiquitination PITNENRkEFVNLYS Q05086 K724-ub Ubiquitination YSDyILNkSVEkQFK Q05086 K728-ub Ubiquitination ILNkSVEkQFKAFRR Q05086 K802-ub Ubiquitination HSFTDEQkRLFLQFT Q05086 K822-ub Ubiquitination APVGGLGkLkMIIAk Q05086 K824-ub Ubiquitination VGGLGkLkMIIAkNG Q05086 K829-ub Ubiquitination kLkMIIAkNGPDTER Q05086 K864-ub Ubiquitination KLKERLLkAITYAkG Q05086 K870-ub Ubiquitination LkAITYAkGFGML__

PTM - dbPTM UniProt ID Position Code Type Resources References Q05086 218 S Phosphorylation Swiss-Prot 1010711 17525332;19690332 Q05086 218 S Phosphorylation PhosphoELM.10011 17525332 Q05086 294 R Methylation Phosphositeplus.1010730 18247584 Q05086 123 K Ubiquitylation Phosphositeplus.1010730 21890473;21906983 Q05086 184 K Ubiquitylation Phosphositeplus.1010730 21906983 Q05086 226 K Ubiquitylation Phosphositeplus.1010730 21906983 Q05086 30 K Ubiquitylation Phosphositeplus.1010730 21890473 Q05086 323 K Ubiquitylation Phosphositeplus.1010730 21890473;21906983 Q05086 330 K Ubiquitylation Phosphositeplus.1010730 21890473 Q05086 350 K Ubiquitylation Phosphositeplus.1010730 21890473 Q05086 373 K Ubiquitylation Phosphositeplus.1010730 21890473 Q05086 468 K Ubiquitylation Phosphositeplus.1010730 21890473 Q05086 552 K Ubiquitylation Phosphositeplus.1010730 21906983 Q05086 553 K Ubiquitylation Phosphositeplus.1010730 21906983 Q05086 71 K Ubiquitylation Phosphositeplus.1010730 20639865;20972266;21890473 Q05086 711 K Ubiquitylation Phosphositeplus.1010730 21890473 Q05086 724 K Ubiquitylation Phosphositeplus.1010730 21890473 Q05086 728 K Ubiquitylation Phosphositeplus.1010730 21890473 Q05086 77 K Ubiquitylation Phosphositeplus.1010730 21890473;21906983 Q05086 802 K Ubiquitylation Phosphositeplus.1010730 21906983 Q05086 829 K Ubiquitylation Phosphositeplus.1010730 21906983 Q05086 90 K Ubiquitylation Phosphositeplus.1010730 21906983 Q05086 217 S Phosphorylation Phosphositeplus.1010730 19690332 Q05086 218 S Phosphorylation Phosphositeplus.1010730 17525332;19690332;20068231;20363803;22115753 Q05086 720 Y Phosphorylation Phosphositeplus.1010730 18083107 Q05086 218 S Phosphorylation HPRD 9.0 17525332,18077418,20068231

PTM - HPRD Symbol Position Code Type References UBE3A 195 S Phosphorylation 17525332,18077418,20068231 UBE3A 215 S Phosphorylation 17525332,18077418,20068231 UBE3A 218 S Phosphorylation 17525332,18077418,20068231

PTM - Phospho.ELM UniProt Position Code PMIDs Kinase Source Type Q05086 218 S 17525332 HTP Phosphorylation

PTM - UniProt UniProt ID Position Type PMIDs Q05086 218 Phosphoserine 17525332;19690332 Q05086 659 Phosphotyrosine; by ABL1 23581475

PTM - BioGRID Entrez Gene BioGRID ID Position Code Type PMIDs 7337 113185 - K Ubiquitination 20639865 7337 113185 - K Ubiquitination 22118674 7337 113185 - K Ubiquitination 21987572 7337 113185 - K Ubiquitination 20972266 7337 113185 - K Ubiquitination 21963094 7337 113185 - K Ubiquitination 21139048 7337 113185 - K Ubiquitination 21890473 7337 113185 - K Ubiquitination 21906983 7337 113185 - K Ubiquitination 21493713 7337 113185 - K Ubiquitination 22053931 7337 113185 - K Ubiquitination 22505724 7337 113185 - K FAT10ylation 22797925 7337 113185 - K Ubiquitination 23000965 7337 113185 - K Ubiquitination 24816145

PTM - mUbiSiDa Gene Name Species Ubiquitination Site Ubiquitination Sequence Evidence PMID UBE3A Homo sapiens (Human) 728; 373; 71; 323; 311; 350; 77; 468; 724; 330; 123; 711; 30 "728,LNKSVEKQFKAFR; 373,AIVAASKCLKMVY; 71,NNAAAIKALELYK; 323,PLAAQGKLIRLWS; 311,ALPLFCKAMSKLP; 350,QQLITYKVISNEF; 77,KALELYKINAKLC; 468,KDYTFFKVETENK; 724,SDYILNKSVEKQF; 330,LIRLWSKYNADQI; 123,GARIDFKDVTYLT; 711,ITNENRKEFVNLY; 30,MKRAAAKHLIERY" 728:21890473; 373:21890473; 71:21890473; 323:21890473; 311:21890473; 350:21890473; 77:21890473; 468:21890473; 724:21890473; 330:21890473; 123:21890473; 711:21890473; 30:21890473 UBE3A Homo sapiens (Human) 33; 21; 83; 178; 40; 434; 421; 438; 60 "33,PLAAQGKLIRLWS; 21,ALPLFCKAMSKLP; 83,AIVAASKCLKMVY; 178,KDYTFFKVETENK; 40,LIRLWSKYNADQI; 434,SDYILNKSVEKQF; 421,ITNENRKEFVNLY; 438,LNKSVEKQFKAFR; 60,QQLITYKVISNEF" 33:21890473; 21:21890473; 83:21890473; 178:21890473; 40:21890473; 434:21890473; 421:21890473; 438:21890473; 60:21890473 UBE3A Homo sapiens (Human) 288; 327; 100; 307; 48; 701; 54; 445; 7; 705; 350; 300; 688 "288,ALPLFCKAMSKLP; 327,QQLITYKVISNEF; 100,GARIDFKDVTYLT; 307,LIRLWSKYNADQI; 48,NNAAAIKALELYK; 701,SDYILNKSVEKQF; 54,KALELYKINAKLC; 445,KDYTFFKVETENK; 7,MKRAAAKHLIERY; 705,LNKSVEKQFKAFR; 350,AIVAASKCLKMVY; 300,PLAAQGKLIRLWS; 688,ITNENRKEFVNLY" 288:21890473; 327:21890473; 100:21890473; 307:21890473; 48:21890473; 701:21890473; 54:21890473; 445:21890473; 7:21890473; 705:21890473; 350:21890473; 300:21890473; 688:21890473 UBE3A Homo sapiens (Human) 48; 7; 109 "48,NNAAAIKALELYK; 7,MKRAAAKHLIERY; 109,TYLTEEKVYEILE" 48:20972266; 7:22053931; 109:22053931 UBE3A Homo sapiens (Human) 550; 68; 549; 308; 370; 799; 347; 708; 74; 826; 465; 327; 87; 223; 320; 721; 27; 725; 181; 120 "550,NPADLKKQLYVEF; 68,NNAAAIKALELYK; 549,ENPADLKKQLYVE; 308,ALPLFCKAMSKLP; 370,AIVAASKCLKMVY; 799,SFTDEQKRLFLQF; 347,QQLITYKVISNEF; 708,ITNENRKEFVNLY; 74,KALELYKINAKLC; 826,LKMIIAKNGPDTE; 465,KDYTFFKVETENK; 327,LIRLWSKYNADQI; 87,DPHPSKKGASSAY; 223,GDNNLQKLGPDDV; 320,PLAAQGKLIRLWS; 721,SDYILNKSVEKQF; 27,MKRAAAKHLIERY; 725,LNKSVEKQFKAFR; 181,LKSLQAKDEDKDE; 120,GARIDFKDVTYLT" "550:21906983; 68:21890473; 549:21906983; 308:21890473; 370:21890473; 799:21906983; 347:21890473; 708:21890473; 74:21890473,21906983; 826:21906983; 465:21890473; 327:21890473; 87:21906983; 223:21906983; 320:21890473,21906983; 721:21890473; 27:21890473; 725:21890473; 181:21906983; 120:21890473,21906983" UBE3A Homo sapiens (Human) 373; 71; 311; 829; 77; 350; 468; 132; 226; 711; 552; 553; 728; 184; 323; 802; 330; 123; 724; 90; 30 "373,AIVAASKCLKMVY; 71,NNAAAIKALELYK; 311,ALPLFCKAMSKLP; 829,LKMIIAKNGPDTE; 77,KALELYKINAKLC; 350,QQLITYKVISNEF; 468,KDYTFFKVETENK; 132,TYLTEEKVYEILE; 226,GDNNLQKLGPDDV; 711,ITNENRKEFVNLY; 552,ENPADLKKQLYVE; 553,NPADLKKQLYVEF; 728,LNKSVEKQFKAFR; 184,LKSLQAKDEDKDE; 323,PLAAQGKLIRLWS; 802,SFTDEQKRLFLQF; 330,LIRLWSKYNADQI; 123,GARIDFKDVTYLT; 724,SDYILNKSVEKQF; 90,DPHPSKKGASSAY; 30,MKRAAAKHLIERY" "373:21890473; 71:21890473; 311:21890473; 829:21906983; 77:21890473,21906983; 350:21890473; 468:21890473; 132:22053931; 226:21906983; 711:21890473; 552:21906983; 553:21906983; 728:21890473; 184:21906983; 323:21890473,21906983; 802:21906983; 330:21890473; 123:21890473,21906983; 724:21890473; 90:21906983; 30:21890473,22053931" UBE3A Homo sapiens (Human) 100; 307; 445; 203; 67; 705; 350; 161; 288; 327; 806; 48; 701; 529; 54; 530; 300; 779; 688 "100,GARIDFKDVTYLT; 307,LIRLWSKYNADQI; 445,KDYTFFKVETENK; 203,GDNNLQKLGPDDV; 67,DPHPSKKGASSAY; 705,LNKSVEKQFKAFR; 350,AIVAASKCLKMVY; 161,LKSLQAKDEDKDE; 288,ALPLFCKAMSKLP; 327,QQLITYKVISNEF; 806,LKMIIAKNGPDTE; 48,NNAAAIKALELYK; 701,SDYILNKSVEKQF; 529,ENPADLKKQLYVE; 54,KALELYKINAKLC; 530,NPADLKKQLYVEF; 300,PLAAQGKLIRLWS; 779,SFTDEQKRLFLQF; 688,ITNENRKEFVNLY" "100:21890473,21906983; 307:21890473; 445:21890473; 203:21906983; 67:21906983; 705:21890473; 350:21890473; 161:21906983; 288:21890473; 327:21890473; 806:21906983; 48:21890473; 701:21890473; 529:21906983; 54:21890473,21906983; 530:21906983; 300:21890473,21906983; 779:21906983; 688:21890473" UBE3A Homo sapiens (Human) 33; 21; 83; 178; 40; 434; 421; 438; 60 "33,PLAAQGKLIRLWS; 21,ALPLFCKAMSKLP; 83,AIVAASKCLKMVY; 178,KDYTFFKVETENK; 40,LIRLWSKYNADQI; 434,SDYILNKSVEKQF; 421,ITNENRKEFVNLY; 438,LNKSVEKQFKAFR; 60,QQLITYKVISNEF" 33:21890473; 21:21890473; 83:21890473; 178:21890473; 40:21890473; 434:21890473; 421:21890473; 438:21890473; 60:21890473 UBE3A Homo sapiens (Human) 68; 308; 67; 370; 347; 708; 74; 465; 327; 54; 320; 721; 27; 725; 120 "68,NNAAAIKALELYK; 308,ALPLFCKAMSKLP; 67,DPHPSKKGASSAY; 370,AIVAASKCLKMVY; 347,QQLITYKVISNEF; 708,ITNENRKEFVNLY; 74,KALELYKINAKLC; 465,KDYTFFKVETENK; 327,LIRLWSKYNADQI; 54,KALELYKINAKLC; 320,PLAAQGKLIRLWS; 721,SDYILNKSVEKQF; 27,MKRAAAKHLIERY; 725,LNKSVEKQFKAFR; 120,GARIDFKDVTYLT" 68:21890473; 308:21890473; 67:21906983; 370:21890473; 347:21890473; 708:21890473; 74:21890473; 465:21890473; 327:21890473; 54:21906983; 320:21890473; 721:21890473; 27:21890473; 725:21890473; 120:21890473