PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus USP4 CT55 26186194 biogrid exp G USP4 TRIM55 22626734 biogrid exp P P GP P P GP P P P P P P GP GP P GP RBL2 USP4 11571651 biogrid exp G GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP G GP GP GP G GP GP G LSM8 USP4 19615732 biogrid,intact exp G GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP G GP GP GP G GP GP G USP4 MEPCE 19615732 biogrid,intact exp G GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP G GP GP GP G GP GP G USP4 AKAP7 19615732 intact exp USP4 RIPK1 23313255,21331078 biogrid,mint,intact exp G GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP G GP GP GP G GP GP G USP4 PRPF31 19615732 biogrid,intact exp G GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP G GP GP GP G GP GP G TK1 USP4 21900206 biogrid,mint,intact exp G GP G GP P G G GP G GP GP GP GP P G G G GP G G GP GP G USP4 DCP1A 19615732 biogrid,intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G USP4 USP21 22626734 biogrid exp G GP G G G GP G GP GP G GP GP GP G G GP GP G GP G GP G GP G GP G GP GP G ATP1B1 USP4 23022198 biogrid exp G GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP G GP GP GP G GP GP G USP4 TRIM63 22626734 biogrid exp G G G G RCC1 USP4 21900206 biogrid,mint,intact exp G GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP G GP GP GP G GP GP G YWHAH USP4 22706160 biogrid exp G GP G G GP GP G GP GP G GP GP GP G G GP GP GP GP G GP G GP GP GP G GP GP G LAMA5 USP4 23022198 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PGM1 USP4 23022198 biogrid exp G GP G G GP GP G GP GP G GP GP G G G GP GP G GP G GP G GP GP GP G GP GP G PTEN USP4 24270891 biogrid exp G GP G G GP GP G G GP G GP G GP GP G GP GP G GP G GP G GP G GP G GP GP G USP4 USP32 19615732 biogrid,intact exp G GP G G G GP G GP GP G GP GP GP G G GP GP G GP G GP G G G GP G GP GP G PRPF4 USP4 19615732 biogrid,intact exp G GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP G GP GP GP G GP GP G PSMD11 USP4 23022198 biogrid exp G GP G G GP GP G GP GP G GP G GP G G G GP G G G GP G G G G G G GP G USP4 NOLC1 11571651 hprd,bci exp G G G G G GP G G GP G G GP GP G G GP GP G G G G G G G GP G GP GP G ATP1B3 USP4 23022198 biogrid exp G GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP G GP GP GP G GP GP G LSM6 USP4 19615732 biogrid,intact exp G GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP G GP GP GP G GP GP G PRPF3 USP4 20595234,19615732 biogrid,intact exp G GP G G G GP G G GP G GP G GP G G GP GP GP GP G GP G GP GP GP G GP GP CDKN1A USP4 21900206 biogrid,mint,intact exp G GP G G GP G G G GP G G G GP G G GP G G G G GP G G G GP G G GP G TNFRSF1A USP4 21331078 biogrid exp G GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP G GP GP GP G GP GP G USP4 NLK 20141612 biogrid exp G GP G G GP GP G G GP G G G G G G G GP G G G GP G G G G G G GP G PSMC5 USP4 23022198 biogrid exp G GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP G GP GP GP G GP GP G PPIA USP4 23022198 biogrid exp G GP G G GP GP G G GP G GP G GP GP G GP GP G GP G GP G GP G GP G GP GP G USP4 TRIM54 22626734 biogrid exp P P GP P P P P G P GP GP P P ANXA7 USP4 21900206 biogrid,mint,intact exp G GP G G GP GP G GP GP G GP GP GP GP G G GP GP GP G GP G GP GP G G GP GP G RORC USP4 25821221 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G USP19 USP4 22706160 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PSMA6 USP4 23022198 biogrid exp P P P P P P P P P P P P P P P P P PSAP USP4 23022198 biogrid exp G GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP G GP GP GP G GP GP G PPIH USP4 19615732 biogrid,intact exp G GP G G GP GP G GP GP GP P GP GP G GP GP GP GP G GP G GP G GP G GP GP G TGFBR1 USP4 22706160 biogrid exp G G G G GP GP G GP GP G GP GP GP G G GP GP G G G G G G G GP G GP G G USP4 TUT1 19615732 biogrid,intact exp G G G G G G G G G G G G G G G G G G G G USP4 ELMO1 26186194 biogrid exp G GP G G G GP G GP G G P GP GP G G G GP GP GP G G G GP G G G GP GP G USP4 TP53BP2 16169070 hprd,biogrid,i2d,intact exp G GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP G GP GP GP G GP GP G USP4 SMN1, SMN2 21900206 biogrid,mint,intact exp P P P P P P P P P P P P P P P P P PLA2G2A USP4 22118674 biogrid exp G GP G GP P G GP GP P G G G G GP GP GP GP GP G G GP GP G GP GP G USP4 USP39 21415856 mint,intact exp G G G G G G G G G G G G G G G G G G G G G G USP4 DCP1B 19615732 biogrid,intact exp G GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP G GP GP GP G GP GP G NPC2 USP4 23022198 biogrid exp G GP G G GP G G G G G GP GP GP GP G G G G GP G GP G GP G G G GP GP G USP4 BRAP 23105109 biogrid exp P G GP P GP P P P P P G GP P P G GP GP GP GP P GP USP4 LSM7 19615732 biogrid,intact exp G GP G G GP GP G GP GP G GP GP GP GP G GP GP G G G GP G GP GP GP G GP GP G USP4 USP28 22626734 biogrid exp G GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP G GP GP GP G GP GP G USP4 LSM4 19615732 biogrid,intact exp G GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP G GP GP GP G GP GP G NTRK1 USP4 25921289 biogrid exp P P G P P P P P P P P P P P P P P PLOD1 USP4 23022198 biogrid exp G G G G G GP G G GP G GP G GP G G GP GP G G G GP G G G GP G GP G G AKT1 USP4 22706160 biogrid exp G GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP G GP GP GP G GP GP G USP4 HUWE1 21522127 biogrid,mint,intact exp G GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP G GP GP GP G GP GP G USP4 LSM2 19615732 biogrid,intact exp G GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP G GP GP GP G GP GP G LGALS1 USP4 23022198 biogrid exp G G G G GP GP G G GP G GP G GP GP G G GP GP G G GP G G G G G G GP G TRAF2 USP4 22029577 biogrid exp P P P P P P P P P P P P P P P P P G GP P PCNA USP4 25404403 biogrid exp G GP G G GP G G G GP G GP G G GP G GP G G GP G GP G GP G GP G GP GP G USP4 OBFC1 26186194 biogrid exp G G G G G GP G GP GP G GP G G G G GP GP G G G GP G GP G GP G G GP G USP4 PDK1 22347420 biogrid exp G GP G G GP GP GP GP G GP GP GP GP G GP GP GP GP G GP G GP GP GP G GP GP AKAP7 USP4 19615732 biogrid exp G GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP G GP GP GP G GP GP G USP4 EDC3 19615732 biogrid,intact exp G GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP G GP GP GP G GP GP G EIF4E2 USP4 19615732 biogrid,intact exp G GP G G G GP G GP G G G GP GP G G G GP G GP G G G GP G G G GP GP G RB1 USP4 11571651,11571652 hprd,biogrid,bci exp G GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP G GP GP GP G GP GP G IKBKB USP4 21331078 biogrid exp G GP G G GP GP G G GP G GP G GP GP G GP GP GP GP G GP G GP G GP G GP GP G USP4 CUL4B 21145461 biogrid exp G GP G G GP GP G GP GP G GP GP G GP G GP GP G GP G GP G GP GP GP G GP GP G USP4 DLC1 24412244 intact exp G G G G G GP G G GP G GP G G G G GP GP G G G G G G G GP G G GP G USP4 SART3 23022198,20595234,19615732 biogrid exp G GP G G GP GP G GP GP G GP G GP GP G GP GP GP GP G GP G GP GP GP G GP GP G MAP3K7 USP4 21331078 biogrid exp G GP G G G GP G G GP G G GP GP G G G GP G GP G GP G G G G G GP GP G USP4 PRPF19 20595234 biogrid exp G GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP G GP GP GP G GP GP G USP4 TCF7L2 20141612 biogrid exp G GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP G GP GP GP G GP GP G USP4 FAM96B 23022198 biogrid exp G GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP G GP GP GP G GP GP G ADSL USP4 19615732 biogrid,intact exp G GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP G GP GP GP G GP GP G ASS1 USP4 23022198 biogrid exp G GP G G GP GP G GP GP G GP GP GP G G GP GP GP GP G GP G GP GP GP G GP GP G SFN USP4 22706160 biogrid exp G G G G G G G G G G G G GP G G G G GP G G G G G G G G G G G USP1 USP4 19615732 biogrid,intact exp G GP G G GP GP G G GP G GP GP G GP G GP GP G G G GP G GP GP GP G GP GP G USP4 TRAF6 22029577,22262844 innatedb,biogrid exp, ortho G GP G G GP G G GP GP G GP GP GP G G GP G GP G G GP G GP G GP G GP GP G USP8 USP4 21415856 mint,intact exp, ortho G GP G G GP GP G G GP G GP G GP G G GP GP G GP G GP G G GP GP G GP GP G DDX58 USP4 23388719 innatedb,biogrid exp, ortho G GP G G GP GP G G GP G GP GP GP GP G GP GP GP P G GP G GP GP GP G GP GP G USP11 USP4 19615732,22706160 innatedb,biogrid,intact exp, ortho G GP G G G GP G G GP G GP G G G G G GP G G G G G G G G G G GP G USP4 USP4 22001210,22706160 biogrid,mint,intact exp, ortho G GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP G GP GP GP G GP GP G UBC USP4 25404403,22195557,16196087,20595234, 21836163 biogrid exp, ortho, pred G GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP G GP GP GP G GP GP G RBL1 USP4 11571651, 25402006 hprd,biogrid,bci exp, pred P G GP P P GP P P P GP P P P P P P GP GP G GP P USP4 TCEAL1 26186194, 25402006 biogrid exp, pred G GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP G GP G GP G GP GP G USP4 USP15 22626734,22706160, 23023127 biogrid exp, pred G GP G G GP GP G G GP G GP GP GP GP G GP GP GP GP G GP G GP GP GP G GP GP G ADORA2A USP4 16339847, 25402006 i2d,intact exp, pred TRIM21 USP4 11461834,23105109,16403452,16472766, 23023127 hprd,biogrid,intact exp, pred G GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP G GP GP GP G GP GP G YWHAE USP4 ortho G GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP G GP GP GP G GP GP G USP4 CREBBP 25402006 pred G GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP G GP GP GP G GP GP G MDM2 USP4 25402006 pred G GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP G GP GP GP G GP GP G CNR1 USP4 25402006 pred G GP G P GP G P GP G P P P GP GP GP GP GP G GP GP P GP GP P G PML USP4 25402006 pred G GP G G GP GP G GP GP G GP G GP GP G GP GP GP GP G GP G GP G GP G GP GP G USP4 SMURF1 23023127 pred G GP G G GP GP G G GP G GP G GP G G G GP GP G G GP G G G G G G GP G USP4 SENP2 23023127 pred G GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP G GP GP GP G GP GP G DRD2 USP4 25402006 pred G G G G GP GP G G GP G GP G GP GP G GP GP G GP G GP G G G GP G GP G G HDAC3 USP4 25402006 pred G GP G G GP GP G GP GP G GP G GP GP G GP GP GP GP G GP G GP GP GP G GP GP G USP4 TCEAL4 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G CCND2 USP4 25402006 pred G GP G G G GP G GP GP G GP GP G G G GP GP G GP G G G G GP GP G GP G G USP4 SKP2 25402006 pred G GP G G GP GP G GP GP G G GP GP GP G GP GP G GP G GP G G GP GP G GP GP G USP4 RARRES2 21836163 pred G G G G G G G G G G G G G G G G G G G G G G G G G G USP4 IRF7 25402006 pred G GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP G GP GP GP G GP GP G USP4 HDAC2 25402006 pred G GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP G GP GP GP G GP GP G PRKCD USP4 23023127 pred G GP G G GP GP G GP GP GP P GP GP G GP GP GP GP GP G GP P GP G GP GP G CUX1 USP4 25402006 pred G GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP G GP GP GP G GP GP G USP4 IRF3 25402006 pred G GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP G GP G GP G GP GP G ADORA1 USP4 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G USP4 THOC1 25402006 pred G GP G G GP GP G GP GP G GP G GP GP G GP GP GP GP G GP G G GP GP G GP GP G UCHL1 USP4 16082366 pred G G G G G GP G G GP G GP G G G G G GP G GP G G G G G G G G GP G KDM5A USP4 25402006 pred G GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP G GP GP GP G GP GP G USP4 NECAB2 25402006 pred G G G GP P G G G GP GP G G G USP4 CYTH2 25402006 pred G G G G GP GP G G G G G GP GP GP G G GP G GP G GP G GP G G G GP GP G MDM4 USP4 25402006 pred G GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP G GP GP GP G GP GP G PRSS2 USP4 16082366 pred G G G G G G G G G G G G G G G G G G G G G G G G G USP4 SNAPC3 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G FLNA USP4 23023127 pred G G G G GP GP G G GP G GP GP GP GP G G GP GP GP G GP G G G G G GP GP G USP4 AMOT 25402006 pred G G G G G G G G G G G G G G G G G G G USP4 KEAP1 25402006 pred G GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP G GP GP GP G GP GP G RELB USP4 25402006 pred G GP G G GP GP GP G GP GP GP GP G GP GP G G G G G G G GP G GP GP G USP4 USP7 25402006 pred G GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP G GP GP GP G GP GP G EGF USP4 23023127 pred P P P GP P GP P P P G P P GP P G GP GP GP P P USP4 RANBP9 25402006 pred G GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP G GP GP GP G GP GP G USP4 PTPRU 23023127 pred G GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP G GP GP GP G GP GP G USP4 TRIP11 25402006 pred G GP G G GP GP G G GP G GP GP GP GP G GP GP GP GP G GP G GP G GP G GP GP G

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B PTEN USP4 MI:0004(affinity chromatography technology) 24270891 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_310058 bait prey LGALS1 USP4 MI:0018(two hybrid) 23022198 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_217834 prey bait USP4 PRPF31 MI:0004(affinity chromatography technology)|MI:0007(anti tag coimmunoprecipitation) 19615732 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_120376|UniProt_100680 bait|bait prey|prey RBL1 USP4 MI:0096(pull down)|MI:0493(in vivo) 11571651 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|- (biogrid)|MI:0468(hprd) BIOGRID_114639|HPRD_18664 prey|- bait|- NAA38 USP4 MI:0007(anti tag coimmunoprecipitation)|MI:0004(affinity chromatography technology) 19615732 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (intact)|(biogrid) UniProt_100680|BIOGRID_120471 prey|prey bait|bait USP4 RIPK1 MI:0007(anti tag coimmunoprecipitation)|MI:0415(enzymatic study)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 21331078,23313255 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (intact)|(biogrid)|(intact)|(intact)|(intact)|(biogrid)|(biogrid) UniProt_128073|BIOGRID_199830|UniProt_128072|UniProt_128074|UniProt_128071|BIOGRID_247361|BIOGRID_247362 prey|bait|bait|prey|prey|bait|prey bait|prey|prey|bait|bait|prey|bait USP4 TP53BP2 MI:0492(in vitro)|MI:0018(two hybrid)|MI:0007(anti tag coimmunoprecipitation) 16169070 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) -|MI:0407(direct interaction)|MI:0915(physical association) MI:0468(hprd)|(biogrid)|(intact) HPRD_30025|BIOGRID_94068|UniProt_156643 -|prey|prey -|bait|bait USP4 CUL4B MI:0004(affinity chromatography technology) 21145461 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_203346 prey bait USP11 USP4 MI:0007(anti tag coimmunoprecipitation)|MI:0004(affinity chromatography technology)|MI:0096(pull down)|MI:0004(affinity chromatography technology) 19615732,22706160 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (intact)|(biogrid)|(biogrid)|(biogrid) UniProt_100658|BIOGRID_119846|BIOGRID_200530|BIOGRID_121765 bait|bait|prey|prey prey|prey|bait|bait ASS1 USP4 MI:0018(two hybrid) 23022198 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_217846 prey bait MAP3K7 USP4 MI:0415(enzymatic study)|MI:0415(enzymatic study)|MI:0415(enzymatic study) 21331078 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid) BIOGRID_199457|BIOGRID_199827|BIOGRID_199828 prey|bait|prey bait|prey|bait PLA2G2A USP4 MI:0415(enzymatic study) 22118674 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_160303 prey bait ATP1B1 USP4 MI:0018(two hybrid) 23022198 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_217843 prey bait USP1 USP4 MI:0004(affinity chromatography technology)|MI:0007(anti tag coimmunoprecipitation) 19615732 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_119847|UniProt_100689 bait|bait prey|prey USP4 USP32 MI:0004(affinity chromatography technology) 19615732 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_120740 bait prey USP4 TRIM54 MI:0415(enzymatic study) 22626734 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_223058 prey bait PSAP USP4 MI:0018(two hybrid) 23022198 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_217837 prey bait IKBKB USP4 MI:0415(enzymatic study) 21331078 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_199829 prey bait USP4 TUT1 MI:0004(affinity chromatography technology)|MI:0007(anti tag coimmunoprecipitation) 19615732 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_120642|UniProt_100680 bait|bait prey|prey USP4 USP28 MI:0415(enzymatic study) 22626734 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_223133 prey bait CDKN1A USP4 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 21900206 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction) (intact)|(intact)|(biogrid) UniProt_158271|UniProt_178869|BIOGRID_157685 bait|bait|bait prey|prey|prey USP4 EDC3 MI:0004(affinity chromatography technology)|MI:0007(anti tag coimmunoprecipitation) 19615732 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_120683|UniProt_100680 bait|bait prey|prey USP4 TRIM63 MI:0415(enzymatic study) 22626734 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_223019 prey bait YWHAH USP4 MI:0096(pull down) 22706160 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_200525 prey bait PRPF4 USP4 MI:0007(anti tag coimmunoprecipitation)|MI:0004(affinity chromatography technology) 19615732 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (intact)|(biogrid) UniProt_100680|BIOGRID_120015 prey|prey bait|bait TRAF2 USP4 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 22029577 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (biogrid)|(biogrid) BIOGRID_154639|BIOGRID_154646 bait|prey prey|bait PPIA USP4 MI:0018(two hybrid) 23022198 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_217845 prey bait PSMA6 USP4 MI:0018(two hybrid) 23022198 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_217842 prey bait ATP1B3 USP4 MI:0018(two hybrid) 23022198 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_217838 prey bait PPIH USP4 MI:0007(anti tag coimmunoprecipitation)|MI:0004(affinity chromatography technology) 19615732 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (intact)|(biogrid) UniProt_100680|BIOGRID_120163 prey|prey bait|bait ANXA7 USP4 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 21900206 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(intact)|(intact) BIOGRID_158436|UniProt_157969|UniProt_178567 bait|bait|bait prey|prey|prey PLOD1 USP4 MI:0018(two hybrid) 23022198 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_217844 prey bait PGM1 USP4 MI:0018(two hybrid) 23022198 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_217847 prey bait TNFRSF1A USP4 MI:0415(enzymatic study) 21331078 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_199831 bait prey DDX58 USP4 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 23388719 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_250051|BIOGRID_250052 prey|bait bait|prey USP4 BRAP MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 23105109 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction)|MI:0407(direct interaction) (biogrid)|(biogrid)|(biogrid) BIOGRID_248151|BIOGRID_248149|BIOGRID_248186 prey|prey|bait bait|bait|prey TRIM21 USP4 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0415(enzymatic study)|MI:0018(two hybrid)|MI:0415(enzymatic study)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 11461834,16403452,16472766,23105109 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0915(physical association)|-|MI:0407(direct interaction) (intact)|(intact)|(biogrid)|(biogrid)|(biogrid)|(intact)|MI:0468(hprd)|(biogrid) UniProt_67933|UniProt_67934|BIOGRID_140005|BIOGRID_116504|BIOGRID_124751|UniProt_67930|HPRD_5594|BIOGRID_248185 bait|bait|prey|bait|bait|bait|-|prey null|null|bait|prey|prey|null|-|bait USP4 HUWE1 MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation)|MI:0004(affinity chromatography technology)|MI:0006(anti bait coimmunoprecipitation)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 21522127 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association) (intact)|(intact)|(intact)|(biogrid)|(intact)|(biogrid)|(biogrid) UniProt_115020|UniProt_115022|UniProt_115021|BIOGRID_158811|UniProt_115019|BIOGRID_158813|BIOGRID_158812 prey|bait|prey|bait|bait|bait|prey bait|prey|bait|prey|prey|prey|bait TCF4 USP4 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 20141612 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_207941|BIOGRID_207939 prey|prey bait|bait SFN USP4 MI:0096(pull down) 22706160 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_200528 prey bait ADSL USP4 MI:0007(anti tag coimmunoprecipitation)|MI:0004(affinity chromatography technology) 19615732 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (intact)|(biogrid) UniProt_100680|BIOGRID_119335 prey|prey bait|bait TGFBR1 USP4 MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down) 22706160 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association)|MI:0407(direct interaction) (biogrid)|(biogrid)|(biogrid) BIOGRID_200436|BIOGRID_200435|BIOGRID_200434 prey|prey|prey bait|bait|bait UBC USP4 MI:0415(enzymatic study)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0415(enzymatic study)|MI:0004(affinity chromatography technology) 16196087,21139048,21890473,21906983,21963094,22118674,22195557,23000965 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid) BIOGRID_160443|BIOGRID_143173|BIOGRID_264807|BIOGRID_268550|BIOGRID_169958|BIOGRID_179235|BIOGRID_199459|BIOGRID_172720 bait|bait|bait|bait|bait|bait|prey|bait prey|prey|prey|prey|prey|prey|bait|prey USP4 USP21 MI:0415(enzymatic study) 22626734 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_223091 prey bait AKAP7 USP4 MI:0004(affinity chromatography technology) 19615732 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_120057 prey bait USP4 LSM7 MI:0007(anti tag coimmunoprecipitation)|MI:0004(affinity chromatography technology) 19615732 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (intact)|(biogrid) UniProt_100680|BIOGRID_120466 bait|bait prey|prey EIF4E2 USP4 MI:0004(affinity chromatography technology)|MI:0007(anti tag coimmunoprecipitation) 19615732 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_120059|UniProt_100680 prey|prey bait|bait USP4 DCP1B MI:0004(affinity chromatography technology)|MI:0007(anti tag coimmunoprecipitation) 19615732 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_120839|UniProt_100680 bait|bait prey|prey ADORA2A USP4 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 16339847 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (intact)|(intact)|(intact)|(intact) UniProt_82725|UniProt_82724|UniProt_82723|UniProt_82722 bait|bait|bait|bait prey|prey|prey|prey USP4 SMN1 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 21900206 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction) (intact)|(intact)|(biogrid) UniProt_157349|UniProt_177947|BIOGRID_158082 prey|prey|prey bait|bait|bait USP4 NLK MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 20141612 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_207942|BIOGRID_207940 bait|bait prey|prey LSM6 USP4 MI:0004(affinity chromatography technology)|MI:0007(anti tag coimmunoprecipitation) 19615732 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_120247|UniProt_100680 prey|prey bait|bait USP4 SART3 MI:0096(pull down)|MI:0004(affinity chromatography technology)|MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down)|MI:0018(two hybrid) 19615732,20595234,23022198 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0407(direct interaction) (biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid) BIOGRID_146670|BIOGRID_121759|BIOGRID_146669|BIOGRID_146668|BIOGRID_146667|BIOGRID_217841 prey|prey|prey|bait|bait|bait bait|bait|bait|prey|prey|prey USP4 USP39 MI:0107(surface plasmon resonance) 21415856 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (intact) UniProt_112891 bait prey USP4 MEPCE MI:0007(anti tag coimmunoprecipitation)|MI:0004(affinity chromatography technology) 19615732 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (intact)|(biogrid) UniProt_100680|BIOGRID_120576 bait|bait prey|prey USP4 PDK1 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 22347420 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (biogrid)|(biogrid) BIOGRID_199232|BIOGRID_199231 prey|bait bait|prey LAMA5 USP4 MI:0018(two hybrid) 23022198 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_217839 prey bait USP8 USP4 MI:0107(surface plasmon resonance) 21415856 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (intact) UniProt_112890 prey bait NPC2 USP4 MI:0018(two hybrid) 23022198 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_217840 prey bait RCC1 USP4 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 21900206 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association) (intact)|(biogrid)|(intact) UniProt_180283|BIOGRID_158134|UniProt_159685 bait|bait|bait prey|prey|prey USP4 USP15 MI:0096(pull down)|MI:0415(enzymatic study) 22626734,22706160 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (biogrid)|(biogrid) BIOGRID_200531|BIOGRID_223109 bait|prey prey|bait USP4 TRAF6 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 22029577 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid)|(biogrid) BIOGRID_154645|BIOGRID_154641|BIOGRID_154642|BIOGRID_154640 bait|bait|prey|prey prey|prey|bait|bait USP4 LSM4 MI:0007(anti tag coimmunoprecipitation)|MI:0004(affinity chromatography technology) 19615732 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (intact)|(biogrid) UniProt_100680|BIOGRID_120350 bait|bait prey|prey USP19 USP4 MI:0096(pull down) 22706160 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_200532 prey bait PSMD11 USP4 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 23022198 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction)|MI:0407(direct interaction) (biogrid)|(biogrid)|(biogrid) BIOGRID_217848|BIOGRID_217849|BIOGRID_217835 bait|bait|prey prey|prey|bait RBL2 USP4 MI:0096(pull down) 11571651 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_114640 prey bait AKT1 USP4 MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down) 22706160 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association)|MI:0407(direct interaction) (biogrid)|(biogrid)|(biogrid) BIOGRID_200439|BIOGRID_200438|BIOGRID_200437 bait|prey|bait prey|bait|prey USP4 FAM96B MI:0018(two hybrid) 23022198 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_217836 bait prey USP4 LSM2 MI:0007(anti tag coimmunoprecipitation)|MI:0004(affinity chromatography technology) 19615732 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (intact)|(biogrid) UniProt_100680|BIOGRID_120617 bait|bait prey|prey USP4 DCP1A MI:0007(anti tag coimmunoprecipitation)|MI:0004(affinity chromatography technology) 19615732 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (intact)|(biogrid) UniProt_100680|BIOGRID_120558 bait|bait prey|prey TK1 USP4 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 21900206 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction) (intact)|(intact)|(biogrid) UniProt_157592|UniProt_178190|BIOGRID_157276 bait|bait|bait prey|prey|prey PRPF3 USP4 MI:0096(pull down)|MI:0004(affinity chromatography technology)|MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down)|MI:0007(anti tag coimmunoprecipitation) 19615732,20595234 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(intact) BIOGRID_146686|BIOGRID_120019|BIOGRID_146666|BIOGRID_146679|BIOGRID_146676|UniProt_100680 prey|prey|prey|prey|bait|prey bait|bait|bait|bait|prey|bait USP4 NOLC1 MI:0493(in vivo) 11571651 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) - MI:0468(hprd) HPRD_10765 - - PSMC5 USP4 MI:0018(two hybrid)|MI:0018(two hybrid) 23022198 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (biogrid)|(biogrid) BIOGRID_217851|BIOGRID_217850 bait|bait prey|prey RB1 USP4 MI:0096(pull down)|MI:0004(affinity chromatography technology)|MI:0493(in vivo)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0096(pull down) 11571651,11571652 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association)|-|MI:0403(colocalization)|MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(biogrid)|MI:0468(hprd)|(biogrid)|(biogrid)|(biogrid) BIOGRID_114638|BIOGRID_137189|HPRD_2626|BIOGRID_137191|BIOGRID_137190|BIOGRID_114641 prey|prey|-|prey|prey|prey bait|bait|-|bait|bait|bait

PPI - HINT Gene A Gene B PMID Method Quality PRPF4 USP4 19615732,19615732 0004,0007 HT PRPF3 USP4 19615732,20595234,20595234,19615732,20595234 0004,0415,0004,0007,0096 HT,LC PPIH USP4 19615732,19615732 0004,0007 HT EIF4E2 USP4 19615732,19615732 0004,0007 HT USP1 USP4 19615732,19615732 0004,0007 HT LSM8 USP4 19615732,19615732 0004,0007 HT RB1 USP4 11571651,11571652,11571651,11571652,11571652 0004,0096,0096,0004,0401 LC UBC USP4 22118674,25404403 0004,0096 LC ADSL USP4 19615732,19615732 0004,0007 HT USP11 USP4 19615732,22706160,19615732 0004,0004,0007 HT,LC LSM6 USP4 19615732,19615732 0004,0007 HT USP4 USP4 22001210,22001210,22001210,22706160,26455393 0071,0096,0077,0004,0004 LC USP4 RIPK1 21331078,23313255,23313255,23313255 0004,0006,0007,0004 LC USP4 CUL4B 21145461 0004 HT USP4 SART3 27060135,20595234,19615732,20595234,27060135,27060135 0096,0096,0004,0004,0004,0114 LC,HT USP4 TCEAL1 26186194 0004 HT USP4 Q59FE1 19615732 0004 HT USP4 MEPCE 19615732,19615732 0004,0007 HT USP4 DCP1B 19615732,19615732 0004,0007 HT USP4 USP32 19615732,19615732 0004,0007 HT USP4 CT55 26186194 0004 HT USP4 PRPF31 19615732,19615732 0004,0007 HT USP4 ELMO1 26186194 0004 HT USP4 EDC3 19615732,19615732 0004,0007 HT USP4 RBBP8 26455393,26387952,26387952 0004,0004,0096 LC USP4 OBFC1 26186194 0004 HT USP4 TUT1 19615732,19615732 0004,0007 HT USP4 DCP1A 19615732,19615732 0004,0007 HT USP4 AKAP7 19615732,19615732 0004,0007 HT USP4 LSM7 19615732,19615732 0004,0007 HT USP4 LSM2 19615732,19615732 0004,0007 HT USP4 TRAF6 22262844,22029577,22029577,22029577 0007,0004,0415,0096 LC USP4 LSM4 19615732,19615732 0004,0007 HT PRPF4 USP4 19615732,19615732 0004,0007 HT PRPF3 USP4 19615732,19615732 0004,0007 HT PPIH USP4 19615732,19615732 0004,0007 HT EIF4E2 USP4 19615732,19615732 0004,0007 HT USP1 USP4 19615732,19615732 0004,0007 HT LSM8 USP4 19615732,19615732 0004,0007 HT ADSL USP4 19615732,19615732 0004,0007 HT USP11 USP4 19615732,19615732 0004,0007 HT LSM6 USP4 19615732,19615732 0004,0007 HT USP4 CUL4B 21145461 0004 HT USP4 SART3 19615732 0004 HT USP4 TCEAL1 26186194 0004 HT USP4 Q59FE1 19615732 0004 HT USP4 MEPCE 19615732,19615732 0004,0007 HT USP4 DCP1B 19615732,19615732 0004,0007 HT USP4 USP32 19615732,19615732 0004,0007 HT USP4 CT55 26186194 0004 HT USP4 PRPF31 19615732,19615732 0004,0007 HT USP4 ELMO1 26186194 0004 HT USP4 EDC3 19615732,19615732 0004,0007 HT USP4 OBFC1 26186194 0004 HT USP4 TUT1 19615732,19615732 0004,0007 HT USP4 DCP1A 19615732,19615732 0004,0007 HT USP4 AKAP7 19615732,19615732 0004,0007 HT USP4 LSM7 19615732,19615732 0004,0007 HT USP4 LSM2 19615732,19615732 0004,0007 HT USP4 LSM4 19615732,19615732 0004,0007 HT PRPF3 USP4 20595234,20595234,20595234 0415,0004,0096 LC RB1 USP4 11571651,11571652,11571651,11571652,11571652 0004,0096,0096,0004,0401 LC UBC USP4 22118674,25404403 0004,0096 LC USP11 USP4 22706160 0004 LC USP4 USP4 22001210,22001210,22001210,22706160,26455393 0071,0096,0077,0004,0004 LC USP4 RIPK1 21331078,23313255,23313255,23313255 0004,0006,0007,0004 LC USP4 SART3 27060135,20595234,20595234,27060135,27060135 0096,0096,0004,0004,0114 LC USP4 RBBP8 26455393,26387952,26387952 0004,0004,0096 LC USP4 TRAF6 22262844,22029577,22029577,22029577 0007,0004,0415,0096 LC PSMD11 USP4 23022198,23022198,23022198 0004,0096,0018 LC LAMA5 USP4 23022198 0018 LC MAP3K7 USP4 21331078,21331078 0004,0415 LC PRPF3 USP4 20595234,20595234,20595234 0415,0004,0096 LC TK1 USP4 21900206 0018 HT ATP1B1 USP4 23022198 0018 LC RB1 USP4 11571652,11571652,11571652 0096,0004,0401 LC PSAP USP4 23022198 0018 LC LGALS1 USP4 23022198 0018 LC UBC USP4 20595234,22195557 0415,0415 LC PCNA USP4 25404403 0415 LC PLA2G2A USP4 22118674 0415 LC RCC1 USP4 21900206 0018 HT TRIM21 USP4 23105109,11461834,16472766,16403452 0018,0018,0415,0415 LC ANXA7 USP4 21900206 0018 HT ADORA2A USP4 16339847,16339847,16339847 0096,0007,0018 LC AKT1 USP4 22706160,22706160,22706160 0415,0004,0096 LC PGM1 USP4 23022198 0018 LC TGFBR1 USP4 22706160,22706160,22706160 0415,0004,0096 LC CDKN1A USP4 21900206 0018 HT USP8 USP4 21415856 0107 LC ATP1B3 USP4 23022198 0018 LC PSMA6 USP4 23022198 0018 LC NPC2 USP4 23022198 0018 LC PLOD1 USP4 23022198 0018 LC TRAF2 USP4 22029577,22029577 0004,0415 LC USP4 USP4 22001210,22001210,22001210 0071,0096,0077 LC USP4 TP53BP2 16169070,16169070 0018,0398 HT USP4 SART3 27060135,23022198,27060135,27060135 0096,0018,0004,0114 LC USP4 PDK1 22347420,22347420 0004,0415 LC USP4 SMN1|SMN2 21900206 0018 HT USP4 USP39 21415856 0107 LC USP4 ASS 23022198 0018 LC USP4 BRAP 23105109,23105109 0018,0004 LC USP4 HUWE1 21522127,21522127,21522127 0006,0415,0004 LC USP4 TRIM63 22626734 0415 HT USP4 DLC1 24412244 0397 LC USP4 USP28 22626734 0415 HT USP4 TRIM54 22626734 0415 HT USP4 TRIM55 22626734 0415 HT USP4 USP21 22626734 0415 HT USP4 FAM96B 23022198 0018 LC USP4 USP15 22626734 0415 HT USP4 TRAF6 22029577,22029577,22029577 0004,0415,0096 LC USP4 HEL-S-69P 23022198 0018 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q53GS9 Q13107 USP39 USP4 0.309 21415856 Q13107 P60484 USP4 PTEN 0.21 24270891 Q13107 O43318 USP4 MAP3K7 0.569 21331078 Q13107 O43395 USP4 PRPF3 0.801 20595234,19615732 Q9H668 Q13107 OBFC1 USP4 0.126 26186194 Q13107 P0CG48 USP4 UBC 0.712 20595234,16196087,25404403,22195557 Q13107 P04629 USP4 NTRK1 0.126 25921289 Q9Y4K3 Q13107 TRAF6 USP4 0.702 22029577 Q13107 P18754 USP4 RCC1 0.332 21900206 Q13107 O43172 USP4 PRPF4 0.236 19615732 Q13107 O43447 USP4 PPIH 0.236 19615732 Q13107 O60573 USP4 EIF4E2 0.236 19615732 Q13107 O95777 USP4 LSM8 0.236 19615732 Q13107 P30566 USP4 ADSL 0.236 19615732 Q13107 P51784 USP4 USP11 0.472 19615732,22706160 Q13107 P62312 USP4 LSM6 0.236 19615732 Q7L2J0 Q13107 MEPCE USP4 0.236 19615732 Q7Z6Z7 Q13107 HUWE1 USP4 0.659 21522127 Q8IZD4 Q13107 DCP1B USP4 0.236 19615732 Q8WWY3 Q13107 PRPF31 USP4 0.236 19615732 Q96F86 Q13107 EDC3 USP4 0.236 19615732 Q99708 Q13107 RBBP8 USP4 0.731 26455393,26387952 Q9H6E5 Q13107 TUT1 USP4 0.236 19615732 Q9NPI6 Q13107 DCP1A USP4 0.236 19615732 Q9NQB0 Q13107 TCF7L2 USP4 0.454 20141612 Q9P0M2 Q13107 AKAP7 USP4 0.236 19615732 Q9UBE8 Q13107 NLK USP4 0.454 20141612 Q9UK45 Q13107 LSM7 USP4 0.236 19615732 Q9Y333 Q13107 LSM2 USP4 0.236 19615732 Q9Y4Z0 Q13107 LSM4 USP4 0.236 19615732 Q13107 O94782 USP4 USP1 0.236 19615732 Q13107 P62195 USP4 PSMC5 0.454 23022198 Q13546 Q13107 RIPK1 USP4 0.757 21331078,23313255 Q13107 P19474 USP4 TRIM21 0.872 16472766,23105109,11461834,16403452 Q13107 P36897 USP4 TGFBR1 0.623 22706160 Q15020 Q13107 SART3 USP4 0.902 20595234,23022198,19615732,27060135 Q13107 P06400 USP4 RB1 0.74 11571651,11571652 Q13107 Q13107 USP4 USP4 0.826 22001210,22706160,26455393 Q8WUE5 Q13107 CT55 USP4 0.126 26186194 Q969Q1 Q13107 TRIM63 USP4 0.183 22626734 Q13107 P35222 USP4 CTNNB1 0.376 26189775 Q92556 Q13107 ELMO1 USP4 0.126 26186194 Q96RU2 Q13107 USP28 USP4 0.183 22626734 Q9BYV2 Q13107 TRIM54 USP4 0.183 22626734 Q9BYV6 Q13107 TRIM55 USP4 0.183 22626734 Q13107 P38936 USP4 CDKN1A 0.183 21900206 Q9UK80 Q13107 USP21 USP4 0.183 22626734 Q9UMS4 Q13107 PRPF19 USP4 0.21 20595234 Q13620 Q13107 CUL4B USP4 0.126 21145461 Q13625 Q13107 TP53BP2 USP4 0.286 16169070 Q13107 Q12933 USP4 TRAF2 0.454 22029577 Q13107 P49959 USP4 MRE11A 0.376 26455393 Q15118 Q13107 PDK1 USP4 0.454 22347420 Q15170 Q13107 TCEAL1 USP4 0.126 26186194 Q13107 P19438 USP4 TNFRSF1A 0.21 21331078 Q16637 Q13107 SMN2 USP4 0.332 21900206 Q13107 P05026 USP4 ATP1B1 0.309 23022198 Q13107 O14920 USP4 IKBKB 0.21 21331078 Q13107 O00231 USP4 PSMD11 0.623 23022198 Q13107 P04183 USP4 TK1 0.332 21900206 Q13107 P00966 USP4 ASS1 0.309 23022198 Q13107 O15230 USP4 LAMA5 0.309 23022198 Q13107 O43687 USP4 AKAP7 0.126 19615732 Q13107 O95786 USP4 DDX58 0.376 23388719 Q13107 O75365 USP4 PTP4A3 0.376 26669864 Q13107 O94966 USP4 USP19 0.21 22706160 Q13107 P09382 USP4 LGALS1 0.309 23022198 Q13107 P07602 USP4 PSAP 0.309 23022198 Q13107 P40818 USP4 USP8 0.309 21415856 Q13107 P14555 USP4 PLA2G2A 0.309 22118674 Q13107 P12004 USP4 PCNA 0.309 25404403 Q13107 P31749 USP4 AKT1 0.623 22706160 Q13107 P20073 USP4 ANXA7 0.183 21900206 Q13107 P28749 USP4 RBL1 0.309 11571651 Q13107 P36871 USP4 PGM1 0.309 23022198 Q13107 P31947 USP4 SFN 0.21 22706160 Q13107 Q02809 USP4 PLOD1 0.309 23022198 Q13107 P54709 USP4 ATP1B3 0.309 23022198 Q13107 P51449 USP4 RORC 0.21 25821221 Q13107 P62937 USP4 PPIA 0.309 23022198 Q13107 P60900 USP4 PSMA6 0.309 23022198 Q13107 P61916 USP4 NPC2 0.309 23022198 Q13107 Q08999 USP4 RBL2 0.309 11571651 Q13107 Q04917 USP4 YWHAH 0.21 22706160 Q9Y4E8 Q13107 USP15 USP4 0.354 22626734,22706160 Q8NFA0 Q13107 USP32 USP4 0.126 19615732 Q4VC15 Q13107 USP32 USP4 0.126 19615732 Q7Z569 Q13107 BRAP USP4 0.416 23105109 Q9Y3D0 Q13107 FAM96B USP4 0.309 23022198 Q92769 Q13107 HDAC2 USP4 0.569 26411366 Q92878 Q13107 RAD50 USP4 0.21 26455393

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 PSMD11 USP4 MI:0045 experimental interaction detection MI:0461 interaction database IKBKB USP4 MI:0045 experimental interaction detection MI:0461 interaction database LAMA5 USP4 MI:0045 experimental interaction detection MI:0461 interaction database PRPF4 USP4 MI:0045 experimental interaction detection MI:0461 interaction database MAP3K7 USP4 MI:0045 experimental interaction detection MI:0461 interaction database PRPF3 USP4 MI:0045 experimental interaction detection MI:0461 interaction database PPIH USP4 MI:0045 experimental interaction detection MI:0461 interaction database AKAP7 USP4 MI:0045 experimental interaction detection MI:0461 interaction database EIF4E2 USP4 MI:0045 experimental interaction detection MI:0461 interaction database HIST1H2BK USP4 MI:0362 inference MI:0461 interaction database PTP4A3 USP4 MI:0045 experimental interaction detection MI:0461 interaction database ULK1 USP4 MI:0362 inference MI:0461 interaction database DNAJB5 USP4 MI:0362 inference MI:0461 interaction database USP1 USP4 MI:0045 experimental interaction detection MI:0461 interaction database USP19 USP4 MI:0045 experimental interaction detection MI:0461 interaction database HSPA4L USP4 MI:0362 inference MI:0461 interaction database LSM8 USP4 MI:0045 experimental interaction detection MI:0461 interaction database DDX58 USP4 MI:0045 experimental interaction detection MI:0461 interaction database ASS1 USP4 MI:0045 experimental interaction detection MI:0461 interaction database MYC USP4 MI:0045 experimental interaction detection MI:0461 interaction database TK1 USP4 MI:0045 experimental interaction detection MI:0461 interaction database NTRK1 USP4 MI:0045 experimental interaction detection MI:0461 interaction database GNAI2 USP4 MI:0362 inference MI:0461 interaction database ATP1B1 USP4 MI:0045 experimental interaction detection MI:0461 interaction database EIF2S1 USP4 MI:0362 inference MI:0461 interaction database RB1 USP4 MI:0045 experimental interaction detection MI:0461 interaction database HIST1H2BJ USP4 MI:0362 inference MI:0461 interaction database PSAP USP4 MI:0045 experimental interaction detection MI:0461 interaction database LGALS1 USP4 MI:0045 experimental interaction detection MI:0461 interaction database UBC USP4 MI:0045 experimental interaction detection MI:0461 interaction database HSPA1A USP4 MI:0362 inference MI:0461 interaction database HSPA1B USP4 MI:0362 inference MI:0461 interaction database DLAT USP4 MI:0362 inference MI:0461 interaction database HSPA8 USP4 MI:0362 inference MI:0461 interaction database PCNA USP4 MI:0045 experimental interaction detection MI:0461 interaction database PLA2G2A USP4 MI:0045 experimental interaction detection MI:0461 interaction database TCF4 USP4 MI:0045 experimental interaction detection MI:0461 interaction database HSPA6 USP4 MI:0362 inference MI:0461 interaction database RCC1 USP4 MI:0045 experimental interaction detection MI:0461 interaction database TNFRSF1A USP4 MI:0045 experimental interaction detection MI:0461 interaction database TRIM21 USP4 MI:0045 experimental interaction detection MI:0461 interaction database CSNK2A2 USP4 MI:0362 inference MI:0461 interaction database EIF2S2 USP4 MI:0362 inference MI:0461 interaction database ANXA7 USP4 MI:0045 experimental interaction detection MI:0461 interaction database TAF1 USP4 MI:0045 experimental interaction detection MI:0461 interaction database FBL USP4 MI:0362 inference MI:0461 interaction database HIST1H2BO USP4 MI:0362 inference MI:0461 interaction database CDK2 USP4 MI:0362 inference MI:0461 interaction database DNAJB1 USP4 MI:0362 inference MI:0461 interaction database RBL1 USP4 MI:0045 experimental interaction detection MI:0461 interaction database ADORA2A USP4 MI:0045 experimental interaction detection MI:0461 interaction database ADSL USP4 MI:0045 experimental interaction detection MI:0461 interaction database AKT1 USP4 MI:0045 experimental interaction detection MI:0461 interaction database SFN USP4 MI:0045 experimental interaction detection MI:0461 interaction database HIST1H2BB USP4 MI:0362 inference MI:0461 interaction database HSPA1L USP4 MI:0362 inference MI:0461 interaction database HSPA4 USP4 MI:0362 inference MI:0461 interaction database CTNNB1 USP4 MI:0045 experimental interaction detection MI:0461 interaction database PGM1 USP4 MI:0045 experimental interaction detection MI:0461 interaction database TGFBR1 USP4 MI:0045 experimental interaction detection MI:0461 interaction database CDKN1A USP4 MI:0045 experimental interaction detection MI:0461 interaction database USP8 USP4 MI:0045 experimental interaction detection MI:0461 interaction database CCT3 USP4 MI:0362 inference MI:0461 interaction database EIF2B2 USP4 MI:0362 inference MI:0461 interaction database MRE11A USP4 MI:0045 experimental interaction detection MI:0461 interaction database RORC USP4 MI:0045 experimental interaction detection MI:0461 interaction database USP11 USP4 MI:0045 experimental interaction detection MI:0461 interaction database HSPA2 USP4 MI:0362 inference MI:0461 interaction database ATP1B3 USP4 MI:0045 experimental interaction detection MI:0461 interaction database SUMO3 USP4 MI:0362 inference MI:0461 interaction database RRP1 USP4 MI:0362 inference MI:0461 interaction database HIST1H2BD USP4 MI:0362 inference MI:0461 interaction database DNAJB13 USP4 MI:0362 inference MI:0461 interaction database PTEN USP4 MI:0045 experimental interaction detection MI:0461 interaction database ACTB USP4 MI:0362 inference MI:0461 interaction database PSMA6 USP4 MI:0045 experimental interaction detection MI:0461 interaction database MAX USP4 MI:0045 experimental interaction detection MI:0461 interaction database NPC2 USP4 MI:0045 experimental interaction detection MI:0461 interaction database SUMO2 USP4 MI:0362 inference MI:0461 interaction database PSMC5 USP4 MI:0045 experimental interaction detection MI:0461 interaction database LSM6 USP4 MI:0045 experimental interaction detection MI:0461 interaction database CNBP USP4 MI:0362 inference MI:0461 interaction database ACTA2 USP4 MI:0362 inference MI:0461 interaction database HIST1H4A USP4 MI:0362 inference MI:0461 interaction database HIST1H2BC USP4 MI:0362 inference MI:0461 interaction database PPIA USP4 MI:0045 experimental interaction detection MI:0461 interaction database SUMO1 USP4 MI:0362 inference MI:0461 interaction database ACTG1 USP4 MI:0362 inference MI:0461 interaction database ACTG2 USP4 MI:0362 inference MI:0461 interaction database CSNK2B USP4 MI:0362 inference MI:0461 interaction database ACTC1 USP4 MI:0362 inference MI:0461 interaction database ACTA1 USP4 MI:0362 inference MI:0461 interaction database CSNK2A1 USP4 MI:0362 inference MI:0461 interaction database E2F1 USP4 MI:0045 experimental interaction detection MI:0461 interaction database PLOD1 USP4 MI:0045 experimental interaction detection MI:0461 interaction database YWHAH USP4 MI:0045 experimental interaction detection MI:0461 interaction database RBL2 USP4 MI:0045 experimental interaction detection MI:0461 interaction database TRAF2 USP4 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database USP4 RIPK1 MI:0045 experimental interaction detection MI:0461 interaction database USP4 CUL4B MI:0045 experimental interaction detection MI:0461 interaction database USP4 TP53BP2 MI:0045 experimental interaction detection MI:0461 interaction database USP4 EIF2B1 MI:0362 inference MI:0461 interaction database USP4 RRP1B MI:0362 inference MI:0461 interaction database USP4 SART3 MI:0045 experimental interaction detection MI:0461 interaction database USP4 PDK1 MI:0045 experimental interaction detection MI:0461 interaction database USP4 TCEAL1 MI:0045 experimental interaction detection MI:0461 interaction database USP4 SMN1 MI:0045 experimental interaction detection MI:0461 interaction database USP4 HIST2H2BE MI:0362 inference MI:0461 interaction database USP4 USP39 MI:0045 experimental interaction detection MI:0461 interaction database USP4 HIST2H2BF MI:0362 inference MI:0461 interaction database USP4 SUMO4 MI:0362 inference MI:0461 interaction database USP4 USP51 MI:0362 inference MI:0461 interaction database USP4 MEPCE MI:0045 experimental interaction detection MI:0461 interaction database USP4 BRAP MI:0045 experimental interaction detection MI:0461 interaction database USP4 HUWE1 MI:0045 experimental interaction detection MI:0461 interaction database USP4 ULK2 MI:0362 inference MI:0461 interaction database USP4 DCP1B MI:0045 experimental interaction detection MI:0461 interaction database USP4 XRN1 MI:0362 inference MI:0461 interaction database USP4 HIST3H2BB MI:0362 inference MI:0461 interaction database USP4 USP32 MI:0045 experimental interaction detection MI:0461 interaction database USP4 CT55 MI:0045 experimental interaction detection MI:0461 interaction database USP4 ZCCHC13 MI:0362 inference MI:0461 interaction database USP4 PRPF31 MI:0045 experimental interaction detection MI:0461 interaction database USP4 GBF1 MI:0362 inference MI:0461 interaction database USP4 ELMO1 MI:0045 experimental interaction detection MI:0461 interaction database USP4 HSPH1 MI:0362 inference MI:0461 interaction database USP4 HDAC2 MI:0045 experimental interaction detection MI:0461 interaction database USP4 KAT2B MI:0362 inference MI:0461 interaction database USP4 RAD50 MI:0045 experimental interaction detection MI:0461 interaction database USP4 HIST1H2BH MI:0362 inference MI:0461 interaction database USP4 TRIM63 MI:0045 experimental interaction detection MI:0461 interaction database USP4 HIST1H2BA MI:0362 inference MI:0461 interaction database USP4 EDC3 MI:0045 experimental interaction detection MI:0461 interaction database USP4 USP28 MI:0045 experimental interaction detection MI:0461 interaction database USP4 SIN3A MI:0362 inference MI:0461 interaction database USP4 HIST1H4G MI:0362 inference MI:0461 interaction database USP4 DNAJC2 MI:0362 inference MI:0461 interaction database USP4 RBBP8 MI:0045 experimental interaction detection MI:0461 interaction database USP4 HIST1H2BN MI:0362 inference MI:0461 interaction database USP4 HIST1H2BM MI:0362 inference MI:0461 interaction database USP4 HIST1H2BL MI:0362 inference MI:0461 interaction database USP4 TRIM54 MI:0045 experimental interaction detection MI:0461 interaction database USP4 TRIM55 MI:0045 experimental interaction detection MI:0461 interaction database USP4 OBFC1 MI:0045 experimental interaction detection MI:0461 interaction database USP4 TUT1 MI:0045 experimental interaction detection MI:0461 interaction database USP4 DCP1A MI:0045 experimental interaction detection MI:0461 interaction database USP4 TCF7L2 MI:0045 experimental interaction detection MI:0461 interaction database USP4 AKAP7 MI:0045 experimental interaction detection MI:0461 interaction database USP4 NLK MI:0045 experimental interaction detection MI:0461 interaction database USP4 DNAJB4 MI:0362 inference MI:0461 interaction database USP4 EIF2B4 MI:0362 inference MI:0461 interaction database USP4 LSM7 MI:0045 experimental interaction detection MI:0461 interaction database USP4 USP21 MI:0045 experimental interaction detection MI:0461 interaction database USP4 PRPF19 MI:0045 experimental interaction detection MI:0461 interaction database USP4 USP22 MI:0362 inference MI:0461 interaction database USP4 RUVBL2 MI:0362 inference MI:0461 interaction database USP4 LSM2 MI:0045 experimental interaction detection MI:0461 interaction database USP4 FAM96B MI:0045 experimental interaction detection MI:0461 interaction database USP4 USP15 MI:0045 experimental interaction detection MI:0461 interaction database USP4 TRAF6 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database USP4 LSM4 MI:0045 experimental interaction detection MI:0461 interaction database