PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus FANCI FANCL 24623813,21775430 biogrid exp GP P G GP GP GP GP G GP GP P GP G GP GP GP P G GP GP GP P GP GP GP GP G DOCK8 FANCL 25416956 biogrid,intact exp GP GP G G GP GP G GP GP G GP G GP GP G G GP G GP G GP GP GP G GP GP GP CCDC36 FANCL 25416956 biogrid,intact exp G P G GP GP P P G P G G G G P GP G GP G G G GP GP P GP GP G FANCL CHCHD3 25416956 biogrid,intact exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G LZTS2 FANCL 25416956 biogrid,intact exp GP GP G G G GP G G GP G GP GP G G G GP GP G GP G GP GP GP G GP G GP GP G KIFC3 FANCL 25416956 biogrid,intact exp G G G G G G G G GP G GP GP G GP G GP G G GP G GP GP G GP GP GP GP G STRA13 FANCL 20347428,20347429 biogrid exp GP G G G G GP G GP GP G GP GP GP GP G G GP G GP G GP GP GP GP G G GP GP G FANCL SSX2IP 25416956 biogrid,intact exp P GP G G G GP G GP GP G GP G GP G GP GP G GP G GP G GP GP GP GP GP G EIF4ENIF1 FANCL 25416956 biogrid,intact exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G HES1 FANCL 18550849 hprd,biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G FAAP20 FANCL 22705371,22343915,24910428 biogrid exp GP G G G G G G G GP G GP GP G G G GP G G GP G GP GP GP G GP G GP G G TFCP2 FANCL 25416956 biogrid,intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PCNA FANCL 20937699 biogrid exp GP GP G G GP G G G GP G GP G G GP G GP G G GP G GP GP GP G GP GP GP GP G FANCL IKZF3 25416956 biogrid,intact exp G G G G G GP G G G G UBE2T FANCL 19111657,24623813,21775430,25464845,24389026,16916645,26046368 biogrid,dip exp G G G GP G GP P P P GP GP P GP P G GP P GP G RBM45 FANCL 25416956 biogrid,intact exp G GP G G GP GP G GP GP G GP GP G GP G GP GP GP P G P GP GP GP GP GP GP GP G GRN FANCL 25416956 biogrid,intact exp GP GP G G GP GP G G GP G GP GP GP GP G GP GP GP GP G GP GP GP G GP GP GP GP G APITD1 FANCL 20347429 biogrid exp FANCL RIMBP3 25416956 biogrid,intact exp FANCL FANCL 17396147,16916645 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G UBE2W FANCL 19111657,21229326,19549727 biogrid,intact exp, ortho GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G GGN FANCL 12574169, 21836163 hprd exp, ortho, pred P P P P P P P P P P P P P P GP FANCC FANCL 16720839,18550849, 25402006, 21836163 biogrid exp, pred GP GP G G GP GP G GP GP G GP GP GP G G GP GP GP GP G GP GP GP GP GP G GP GP G FANCA FANCL 22705371,17396147,22343915,16116422,18174376,16474167,21975120,20347428,12973351,20347429,16720839,18550849,17289582, 25402006, 21836163 biogrid,intact exp, pred G G G G G G G G G G G G G G G G G G G G G G G FANCD2 FANCL 24623813,21775430, 25402006, 21836163 biogrid exp, pred G G P P GP P G G GP P G GP P P GP G GP GP FAAP24 FANCL 17289582, 25402006 biogrid exp, pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G FANCG FANCL 16720839,20347429,22343915,18174376,16474167,24910428, 25402006, 21836163 biogrid exp, pred G GP G G GP GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP G GP GP GP GP G FANCF FANCL 16720839,16474167,24910428, 25402006, 21836163 biogrid exp, pred G G G G G G G G G G G G G G G G G G G G G G ACVR1 FANCL 15761153, 21836163 hprd,i2d exp, pred GP GP G G G GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP G GP GP GP GP GP G FANCM FANCL 17396147,22343915,16116422,18174376,24910428,20347428,20347429,16720839,18285517,17289582, 25402006, 21836163 biogrid exp, pred G G G G G G G G G G G G G G G FANCB FANCL 16720839,17396147, 25402006, 21836163 biogrid,intact exp, pred P P G G P P G P P P P P G GP P P P P P P G TGFBR1 FANCL 15761153, 21836163 hprd,i2d exp, pred GP G G G GP GP G GP GP G GP GP GP G G GP GP G G G G G G G GP G GP G G BMPR1B FANCL 15761153, 21836163 hprd,i2d exp, pred P GP G G GP GP G GP GP G GP P GP G GP GP GP GP G P GP P GP GP GP GP GP G FAAP100 FANCL 20347429,17396147,22343915,24910428, 25402006, 21836163 hprd,biogrid,intact exp, pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP G GP GP G RNF20 FANCL 21836163 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G SMARCA4 FANCL 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G MIB1 FANCL 21836163 pred GP GP G G GP GP G G GP G GP GP G GP G GP GP GP GP G GP GP GP G GP G GP GP G BRCA2 FANCL 25402006 pred P P G GP P P P P P P P P P P P P P P P P P GP G CHUK FANCL 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G CHEK1 FANCL 25402006 pred G G G GP AKT1 FANCL 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G UHRF1 FANCL 21836163 pred G G G G G G G G G G G G G G G RNF25 FANCL 21836163 pred P G P P P P P P P P P P P P P GP P P CDK1 FANCL 25402006 pred GP G GP G GP P P P GP GP GP G GP P GP GP GP GP TRAF7 FANCL 21836163 pred GP GP G G G GP G GP GP G GP GP GP G G GP GP G G G G G GP GP GP G GP GP G ATR FANCL 25402006 pred G GP G G G GP G GP GP G GP GP GP G G G GP G GP G GP G G G G G G GP G LUC7L3 FANCL 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G HMGB2 FANCL 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G FANCL AMFR 21836163 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G FANCL DTL 25402006 pred P P G GP P G P P P G P GP P P P P G G G GP PIR51 FANCL 25402006 pred P G G P GP GP P P GP GP GP LRSAM1 FANCL 21836163 pred P GP G P GP G P GP G GP GP P GP P GP GP GP G P GP P P P GP P P G CNOT4 FANCL 21836163 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G TRIM5 FANCL 21836163 pred GP GP G GP P G GP GP GP GP GP GP G GP P GP GP G GP GP GP P GP GP GP P G GRB2 FANCL 25402006 pred GP GP G G GP GP G G GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G IKBKB FANCL 25402006 pred GP GP G G GP GP G G GP G GP G GP GP G GP GP GP GP G GP GP GP G GP GP GP GP G MYLIP FANCL 21836163 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G FANCL SNX5 25402006 pred GP GP G G GP GP G G GP G GP GP GP GP G GP GP GP GP G GP GP GP G GP G GP GP G USP1 FANCL 25402006 pred GP GP G G GP GP G G GP G GP GP G GP G GP GP G G G GP G GP GP GP GP GP GP G FANCE FANCL 25402006, 21836163 pred GP P G GP P G P P GP GP G GP GP GP GP G GP GP GP GP GP GP P GP G ERCC4 FANCL 25402006 pred GP GP G G G GP G GP GP G GP GP GP GP G G GP G GP G GP GP GP G G GP GP GP G PJA1 FANCL 21836163 pred GP GP G G GP GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G RNF144B FANCL 21836163 pred G GP G G G GP G GP GP G GP GP GP G G GP GP GP GP G GP G G G GP G G GP G NFX1 FANCL 21836163 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G XPO1 FANCL 25402006 pred GP GP G G GP GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G TRIM11 FANCL 21836163 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP P GP GP GP GP G FANCL SMC3 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP G GP GP G BRAP FANCL 21836163 pred P P G GP P GP P P P P P G GP P P G GP P GP GP GP P P GP TOPBP1 FANCL 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G BRCA1 FANCL 25402006 pred P P G GP P P P P P P P GP P P P P P P P P P P GP LNX1 FANCL 21836163 pred GP G G GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP G GP P GP GP BLM FANCL 21836163 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G ZBED1 FANCL 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G UFL1 FANCL 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP G GP G GP GP G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q9NW38 - 4294967295 - C 8 Q9NW38 anti bait coimmunoprecipitation 12724401 association C 9 Q9NW38 anti bait coimmunoprecipitation 12724401 association C 11 Q9NW38 anti tag coimmunoprecipitation 15502827 association C 9 Q9NW38 anti bait coimmunoprecipitation 12973351 association C 11 Q9NW38 coimmunoprecipitation 16116422 association C 8 Q9NW38 anti bait coimmunoprecipitation 12724401 association C 13 Q9NW38 A0A024R9A9 molecular sieving 24389026 direct interaction X 2 Q9NW38 A0A024R9A9 molecular sieving 24389026 direct interaction X 2 Q9NW38 A0A024R9A9 comigration in non denaturing gel electrophoresis 24389026 direct interaction X 2 Q9NW38 in vivo 17396147 - C 5 Q9NW38 in vivo 17396147 - C 5 Q9NW38 in vivo 17396147 - C 5 Q9NW38 in vivo 17396147 - C 5 Q9NW38 in vivo 17396147 - C 5 Q9NW38 O00238 in vivo 15761153 - X 2 Q9NW38 Q86UU5-2 in vivo 12574169 - X 2 Q9NW38 Q86UU5-2 two hybrid 12574169 - X 2 Q9NW38 O00238 in vivo 15761153 - X 2 Q9NW38 Q86UU5-2 two hybrid 12574169 - X 2 Q9NW38 Q86UU5-2 in vivo 12574169 - X 2 Q9NW38 D3DPA4 in vivo 15761153 - X 2 Q9NW38 Q14469 in vivo 18550849 - X 2 Q9NW38 Q14469 two hybrid 18550849 - X 2 Q9NW38 P36897-3 in vivo 15761153 - X 2 Q9NW38 Q14469 two hybrid 18550849 - X 2 Q9NW38 Q14469 in vivo 18550849 - X 2 Q9NW38 D3DPA4 in vivo 15761153 - X 2 Q9NW38 P36897-3 in vivo 15761153 - X 2 Q9NW38 Q0VG06 two hybrid 17396147 - X 2 Q9NW38 Q0VG06 in vivo 17396147 - X 2 Q9NW38 Q0VG06 in vivo 17396147 - X 2 Q9NW38 Q0VG06 two hybrid 17396147 - X 2 Q9NW38 protein three hybrid 17396147 physical association C 3 Q9NW38 Q96B02 two hybrid 19549727 physical association X 2 Q9NW38 Q8IUH3 two hybrid prey pooling approach 25416956 physical association X 2 Q9NW38 A0A024R120 two hybrid prey pooling approach 25416956 physical association X 2 Q9NW38 Q8NF50-2 two hybrid prey pooling approach 25416956 physical association X 2 Q9NW38 Q9UFD9 two hybrid prey pooling approach 25416956 physical association X 2 Q9NW38 A4D1N4 two hybrid prey pooling approach 25416956 physical association X 2 Q9NW38 Q8IUH3 two hybrid array 25416956 physical association X 2 Q9NW38 A0A024R120 two hybrid array 25416956 physical association X 2 Q9NW38 Q8NF50-2 two hybrid array 25416956 physical association X 2 Q9NW38 Q9UFD9 two hybrid array 25416956 physical association X 2 Q9NW38 A4D1N4 two hybrid array 25416956 physical association X 2 Q9NW38 Q8IUH3 validated two hybrid 25416956 physical association X 2 Q9NW38 A0A024R120 validated two hybrid 25416956 physical association X 2 Q9NW38 Q8NF50-2 validated two hybrid 25416956 physical association X 2 Q9NW38 A4D1N4 validated two hybrid 25416956 physical association X 2 Q9NW38 Q9UFD9 validated two hybrid 25416956 physical association X 2 Q9BVG8 Q9NW38 two hybrid prey pooling approach 25416956 physical association X 2 Q9BVG8 Q9NW38 two hybrid array 25416956 physical association X 2 Q9BVG8 Q9NW38 validated two hybrid 25416956 physical association X 2 Q9NW38 anti bait coimmunoprecipitation 17396147 association C 6 Q9NW38 anti bait coimmunoprecipitation 17396147 association C 6 Q9NW38 anti bait coimmunoprecipitation 17396147 association C 4 Q9NW38 molecular sieving 17396147 colocalization C 4 Q8IYA8 Q9NW38 two hybrid prey pooling approach 25416956 physical association X 2 Q8IYA8 Q9NW38 two hybrid array 25416956 physical association X 2 Q8IYA8 Q9NW38 validated two hybrid 25416956 physical association X 2 Q9NW38 P28799 two hybrid prey pooling approach 25416956 physical association X 2 Q9NW38 Q9BRK4 two hybrid prey pooling approach 25416956 physical association X 2 Q9NW38 A0A024R1K0 two hybrid prey pooling approach 25416956 physical association X 2 Q9NW38 Q9UKT9 two hybrid prey pooling approach 25416956 physical association X 2 Q9NW38 Q9Y2D8 two hybrid prey pooling approach 25416956 physical association X 2 Q9NW38 P28799 two hybrid array 25416956 physical association X 2 Q9NW38 Q9BRK4 two hybrid array 25416956 physical association X 2 Q9NW38 A0A024R1K0 two hybrid array 25416956 physical association X 2 Q9NW38 Q9UKT9 two hybrid array 25416956 physical association X 2 Q9NW38 Q9Y2D8 two hybrid array 25416956 physical association X 2 Q9NW38 Q9BRK4 validated two hybrid 25416956 physical association X 2 Q9NW38 P28799 validated two hybrid 25416956 physical association X 2 Q9NW38 A0A024R1K0 validated two hybrid 25416956 physical association X 2 Q9NW38 Q9UKT9 validated two hybrid 25416956 physical association X 2 Q9NW38 Q9Y2D8 validated two hybrid 25416956 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B FANCB FANCL MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0493(in vivo) 16720839,17396147 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0407(direct interaction)|- (biogrid)|(biogrid)|(biogrid)|(biogrid)|MI:0468(hprd) BIOGRID_139463|BIOGRID_139891|BIOGRID_139459|BIOGRID_139892|HPRD_39587 prey|prey|bait|bait|- bait|bait|prey|prey|- FAAP24 FANCL MI:0096(pull down) 17289582 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_139498 bait prey ACVR1 FANCL MI:0493(in vivo) 15761153 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) - MI:0468(hprd) HPRD_17206 - - FANCC FANCL MI:0004(affinity chromatography technology)|MI:0018(two hybrid) 16720839,18550849 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_139888|BIOGRID_139324 bait|bait prey|prey FANCI FANCL MI:0096(pull down)|MI:0415(enzymatic study)|MI:0401(biochemical) 21775430,22287633,24623813 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0407(direct interaction) (biogrid)|(biogrid)|(biogrid) BIOGRID_199185|BIOGRID_207589|BIOGRID_307885 bait|prey|prey prey|bait|bait BMPR1B FANCL MI:0493(in vivo) 15761153 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) - MI:0468(hprd) HPRD_17397 - - HES1 FANCL MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 18550849 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) -|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association) MI:0468(hprd)|(biogrid)|(biogrid)|(biogrid) HPRD_32808|BIOGRID_139308|BIOGRID_139330|BIOGRID_139312 -|bait|bait|bait -|prey|prey|prey FANCG FANCL MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation) 16474167,16720839,17396147,18174376,20347429 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0403(colocalization)|MI:0403(colocalization)|MI:0403(colocalization) (biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|MI:0471(mint)|(intact)|MI:0471(mint) BIOGRID_136602|BIOGRID_139383|BIOGRID_136596|BIOGRID_139894|BIOGRID_124743|MINT_53196|UniProt_90107|MINT_86766 bait|prey|prey|bait|prey|neutral component|neutral component|neutral component prey|bait|bait|prey|bait|neutral component|neutral component|neutral component UBE2T FANCL MI:0096(pull down)|MI:0114(x-ray crystallography)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0114(x-ray crystallography)|MI:0415(enzymatic study)|MI:0018(two hybrid)|MI:0401(biochemical) 16916645,21775430,22287633,24389026,24623813 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0914(association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0407(direct interaction) (biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid) BIOGRID_199184|BIOGRID_307611|BIOGRID_139876|BIOGRID_139875|BIOGRID_307612|BIOGRID_225940|BIOGRID_223064|BIOGRID_307883 prey|prey|prey|bait|prey|prey|prey|bait bait|bait|bait|prey|bait|bait|bait|prey FANCF FANCL MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 16474167,16720839 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_124744|BIOGRID_139885 prey|bait bait|prey FANCM FANCL MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0096(pull down)|MI:0004(affinity chromatography technology)|MI:0493(in vivo) 16116422,16720839,17289582,17396147,18174376,18285517,20347428,20347429 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|- (biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|MI:0468(hprd) BIOGRID_139466|BIOGRID_139896|BIOGRID_136593|BIOGRID_139382|BIOGRID_117408|BIOGRID_123049|BIOGRID_140029|BIOGRID_140038|BIOGRID_139494|BIOGRID_140027|HPRD_39587 prey|bait|prey|prey|bait|bait|prey|bait|bait|bait|- bait|prey|bait|bait|prey|prey|bait|prey|prey|prey|- FAAP100 FANCL MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation)|MI:0493(in vivo)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0493(in vivo) 17396147,20347429 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0914(association)|MI:0914(association)|MI:0914(association)|MI:0403(colocalization)|MI:0403(colocalization)|MI:0403(colocalization)|-|MI:0915(physical association)|MI:0914(association)|MI:0915(physical association)|MI:0915(physical association)|- (intact)|MI:0471(mint)|MI:0471(mint)|MI:0471(mint)|(intact)|MI:0471(mint)|MI:0471(mint)|(intact)|MI:0471(mint)|MI:0468(hprd)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|MI:0468(hprd) UniProt_90106|MINT_53198|MINT_86768|MINT_53194|UniProt_90104|MINT_86764|MINT_53196|UniProt_90107|MINT_86766|HPRD_39587|BIOGRID_139465|BIOGRID_139467|BIOGRID_139445|BIOGRID_136595|HPRD_30486 bait|bait|bait|bait|bait|bait|neutral component|neutral component|neutral component|-|prey|prey|bait|prey|- prey|prey|prey|prey|prey|prey|neutral component|neutral component|neutral component|-|bait|bait|prey|bait|- FANCA FANCL MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0096(pull down)|MI:0004(affinity chromatography technology)|MI:0018(two hybrid)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation)|MI:0493(in vivo) 12973351,16116422,16474167,16720839,17289582,17396147,18174376,18550849,20347428,20347429,21975120,22705371 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0914(association)|MI:0914(association)|MI:0914(association)|MI:0914(association)|MI:0914(association)|MI:0914(association)|MI:0403(colocalization)|MI:0403(colocalization)|MI:0403(colocalization)|- (biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|MI:0471(mint)|MI:0471(mint)|MI:0471(mint)|(intact)|(intact)|MI:0471(mint)|MI:0471(mint)|(intact)|MI:0471(mint)|MI:0468(hprd) BIOGRID_139455|BIOGRID_139464|BIOGRID_195859|BIOGRID_152849|BIOGRID_139381|BIOGRID_136594|BIOGRID_85655|BIOGRID_139503|BIOGRID_140030|BIOGRID_139318|BIOGRID_139448|BIOGRID_124742|BIOGRID_139884|BIOGRID_123055|MINT_53193|MINT_86761|MINT_86763|UniProt_90102|UniProt_90103|MINT_53191|MINT_53196|UniProt_90107|MINT_86766|HPRD_39587 bait|prey|bait|bait|prey|prey|bait|bait|prey|bait|bait|prey|bait|bait|prey|bait|prey|bait|prey|bait|neutral component|neutral component|neutral component|- prey|bait|prey|prey|bait|bait|prey|prey|bait|prey|prey|bait|prey|prey|prey|prey|prey|prey|prey|prey|neutral component|neutral component|neutral component|- TGFBR1 FANCL MI:0493(in vivo) 15761153 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) - MI:0468(hprd) HPRD_17704 - - NRF1 FANCL MI:0428(imaging technique) 24250222 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_295134 bait prey APITD1 FANCL MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 20347429 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0403(colocalization) (biogrid)|(biogrid)|(biogrid)|(biogrid) BIOGRID_136576|BIOGRID_136587|BIOGRID_136597|BIOGRID_136608 bait|bait|prey|bait prey|prey|bait|prey FANCL STRA13 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 20347429 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_136577|BIOGRID_136598 prey|bait bait|prey UBD FANCL MI:0004(affinity chromatography technology) 22797925 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_226358 bait prey FANCD2 FANCL MI:0096(pull down)|MI:0415(enzymatic study)|MI:0401(biochemical) 21775430,22287633,24623813 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0407(direct interaction) (biogrid)|(biogrid)|(biogrid) BIOGRID_199186|BIOGRID_207590|BIOGRID_307884 bait|prey|prey prey|bait|bait PCNA FANCL MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 20937699 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid) BIOGRID_136192|BIOGRID_136196|BIOGRID_136195 bait|prey|prey prey|bait|bait UBE2W FANCL MI:0018(two hybrid)|MI:0090(protein complementation assay)|MI:0090(protein complementation assay)|MI:0090(protein complementation assay) 19549727,21229326 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0407(direct interaction) (intact)|(biogrid)|(biogrid)|(biogrid) UniProt_100916|BIOGRID_135864|BIOGRID_135865|BIOGRID_135866 bait|bait|prey|prey prey|prey|bait|bait GGN FANCL MI:0493(in vivo) 12574169 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) - MI:0468(hprd) HPRD_14561 - - CTNNB1 FANCL MI:0004(affinity chromatography technology) 22653977 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_186244 prey bait UBC FANCL MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 21906983,21963094 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_265257|BIOGRID_181379 bait|bait prey|prey

PPI - HINT Gene A Gene B PMID Method Quality STRA13 FANCL 20347429,20347428 0004,0004 LC B4E3W2 FANCL 16720839,18550849 0004,0004 LC FANCG FANCL 22343915,16720839,20347429,24910428,18174376,16474167 0004,0004,0004,0428,0004,0004 LC FANCA FANCL 17396147,18174376,17396147,16116422,21975120,16720839,20347429,17396147,22705371,12973351,18550849,17289582,20347428,22343915,16474167 0071,0004,0006,0004,0004,0004,0004,0004,0004,0004,0004,0004,0004,0004,0004 LC FANCC FANCL 16720839,18550849 0004,0004 LC FAAP100 FANCL 24910428,22343915,17396147,24910428,20347429,17396147,17396147,17396147,17396147 0401,0004,0006,0004,0004,0004,0401,0018,0437 LC PPP1R7 FANCL 27173435 0676 HT Q7Z4P6 FANCL 24910428,22705371,22343915 0428,0004,0004 LC FANCM FANCL 22343915,16116422,16720839,20347429,17396147,24910428,20347428,17289582,18174376,18285517 0004,0004,0004,0004,0004,0428,0004,0004,0004,0004 LC UBE2T FANCL 21775430,16916645,26046368,24389026,16916645,24389026,24389026,24623813,16916645,26046368,24389026 0096,0096,0018,0404,0004,0096,0071,0096,0018,0096,0114 LC FANCF FANCL 16720839,16474167,24910428 0004,0004,0428 LC FANCL FANCL 17396147 0004 LC PPP1R7 FANCL 27173435 0676 HT STRA13 FANCL 20347429,20347428 0004,0004 LC B4E3W2 FANCL 16720839,18550849 0004,0004 LC FANCG FANCL 22343915,16720839,20347429,24910428,18174376,16474167 0004,0004,0004,0428,0004,0004 LC FANCA FANCL 17396147,18174376,17396147,16116422,21975120,16720839,20347429,17396147,22705371,12973351,18550849,17289582,20347428,22343915,16474167 0071,0004,0006,0004,0004,0004,0004,0004,0004,0004,0004,0004,0004,0004,0004 LC FANCC FANCL 16720839,18550849 0004,0004 LC FAAP100 FANCL 24910428,22343915,17396147,24910428,20347429,17396147,17396147,17396147,17396147 0401,0004,0006,0004,0004,0004,0401,0018,0437 LC Q7Z4P6 FANCL 24910428,22705371,22343915 0428,0004,0004 LC FANCM FANCL 22343915,16116422,16720839,20347429,17396147,24910428,20347428,17289582,18174376,18285517 0004,0004,0004,0004,0004,0428,0004,0004,0004,0004 LC UBE2T FANCL 21775430,16916645,26046368,24389026,16916645,24389026,24389026,24623813,16916645,26046368,24389026 0096,0096,0018,0404,0004,0096,0071,0096,0018,0096,0114 LC FANCF FANCL 16720839,16474167,24910428 0004,0004,0428 LC FANCL FANCL 17396147 0004 LC BMPR1B FANCL 15761153 0019 HT FANCA FANCL 17396147,17396147,17396147 0071,0006,0004 LC GRN FANCL 25416956,25416956,25416956,25416956 1112,0397,0018,1356 HT TGFBR1 FANCL 15761153 0019 HT ACVR1 FANCL 15761153 0019 HT FAAP100 FANCL 24910428,17396147,24910428,17396147,17396147,17396147,17396147 0401,0006,0004,0004,0401,0018,0437 LC TFCP2 FANCL 25416956,25416956,25416956,25416956 1112,0397,0018,1356 HT HES1 FANCL 18550849,18550849 0018,0004 LC GGN FANCL 12574169 0018 LC RBM45 FANCL 25416956,25416956,25416956,25416956 1112,0397,0018,1356 HT CCDC36 FANCL 25416956,25416956,25416956,25416956 1112,0397,0018,1356 HT FANCB FANCL 16720839 0018 LC DOCK8 FANCL 25416956,25416956,25416956,25416956 1112,0397,0018,1356 HT UBE2W FANCL 21229326,21229326,19111657,19549727 0096,0090,0018,0018 LC,HT LZTS2 FANCL 25416956,25416956,25416956,25416956 1112,0397,0018,1356 HT KIFC3 FANCL 25416956,25416956,25416956,25416956 1112,0397,0018,1356 HT FANCD2 FANCL 24623813 0415 LC UBE2T FANCL 16916645,26046368,25464845,24389026,19111657,16916645,24389026,24389026,16916645,26046368,24389026 0096,0018,0090,0404,0018,0004,0096,0071,0018,0096,0114 LC EIF4ENIF1 FANCL 25416956,25416956,25416956,25416956 1112,0397,0018,1356 HT FANCI FANCL 24623813 0415 LC FANCL FANCL 16916645,24389026,21775430 0415,0114,0114 LC FANCL CHCHD3 25416956,25416956,25416956,25416956 1112,0397,0018,1356 HT FANCL RIMBP3 25416956,25416956,25416956,25416956 1112,0397,0018,1356 HT FANCL IKZF3 25416956,25416956,25416956,25416956 1112,0397,0018,1356 HT FANCL SSX2IP 25416956,25416956,25416956,25416956 1112,0397,0018,1356 HT

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q9NW38 Q8NF50 FANCL DOCK8 0.454 25416956 Q9NW38 Q9NVI1 FANCL FANCI 0.523 24623813,21775430 Q9NW38 A8MT69 FANCL STRA13 0.454 20347429,20347428 Q9NW38 Q6NZ36 FANCL FAAP20 0.472 24910428,22705371,22343915 Q9NW38 Q8IYA8 FANCL CCDC36 0.454 25416956 Q9NW38 Q8N2Z9 FANCL APITD1 0.454 20347429 Q9NW38 Q9NPI8 FANCL FANCF 0.454 16720839,24910428,16474167 Q9NW38 Q9NRA8 FANCL EIF4ENIF1 0.454 25416956 Q9NW38 P12004 FANCL PCNA 0.569 20937699 Q9P0T4 Q9NW38 ZNF581 FANCL 0.236 unassigned1304 Q9NW38 Q8IUH3 FANCL RBM45 0.454 25416956 Q9NW38 Q3LI70 FANCL KRTAP19-6 0.236 unassigned1304 Q9NW38 F5H3M2 FANCL KIFC3 {ECO:0000313|ENSEMBL:ENSP00000438805} 0.236 unassigned1304 Q9NW38 Q12800 FANCL TFCP2 0.454 25416956 Q9NW38 Q8NB91 FANCL FANCB 0.765 16720839,17396147 Q9NW38 Q9BVG8 FANCL KIFC3 0.454 25416956 Q9NW38 Q9NW38 FANCL FANCL 0.49 16916645,17396147 Q9UFD9 Q9NW38 RIMBP3 FANCL 0.454 25416956 Q9Y2D8 Q9NW38 SSX2IP FANCL 0.454 25416956 Q9Y3C5 Q9NW38 RNF11 FANCL 0.236 unassigned1304 Q9NW38 P09016 FANCL HOXD4 0.236 unassigned1304 Q9NW38 Q96H20 FANCL SNF8 0.236 unassigned1304 Q9NW38 P15976 FANCL GATA1 0.236 unassigned1304 Q9NW38 Q14469 FANCL HES1 0.454 18550849 Q9NW38 Q9BSH5 FANCL HDHD3 0.236 unassigned1304 Q9NW38 Q9BWG6 FANCL SCNM1 0.236 unassigned1304 Q9NW38 Q9GZU7 FANCL CTDSP1 0.236 unassigned1304 Q9NW38 Q9H079 FANCL KATNBL1 0.236 unassigned1304 Q9NW38 A2RRN7 FANCL CADPS {ECO:0000313|EMBL:AAI31732.1} 0.236 unassigned1304 Q9NW38 Q15435 FANCL PPP1R7 0.236 27173435,unassigned1312 Q9NW38 Q00597 FANCL FANCC 0.376 16720839,18550849 Q9NW38 Q52LG2 FANCL KRTAP13-2 0.236 unassigned1304 Q9NW38 J3KR25 FANCL TRIB3 {ECO:0000313|ENSEMBL:ENSP00000415416} 0.236 unassigned1304 Q9NW38 Q02363 FANCL ID2 0.236 unassigned1304 Q9NW38 Q5BKX5 FANCL C19ORF54 0.236 unassigned1304 Q9NW38 A6NJ78 FANCL METTL15 0.236 unassigned1304 Q9NW38 Q5T4B2 FANCL CERCAM 0.236 unassigned1304 Q9NW38 Q6NVU6 FANCL UFSP1 0.236 unassigned1304 Q9NW38 Q6ZR03 FANCL Q6ZR03 0.236 unassigned1304 Q9NW38 Q8IUC1 FANCL KRTAP11-1 0.236 unassigned1304 Q9NW38 Q6PF18 FANCL MORN3 0.236 unassigned1304 Q9NW38 O95865 FANCL DDAH2 0.236 unassigned1304 Q9NW38 Q9NPD8 FANCL UBE2T 0.987 24389026,24623813,26046368,21775430,25464845,16916645,19111657 Q9NW38 O15287 FANCL FANCG 0.794 24910428,16474167,22343915,18174376,16720839,20347429 Q9NX63 Q9NW38 CHCHD3 FANCL 0.454 25416956 Q9NW38 Q0VG06 FANCL FAAP100 0.872 24910428,17396147,20347429,22343915 Q9NW38 P28799 FANCL GRN 0.454 25416956 Q9NW38 Q8IYD8 FANCL FANCM 0.899 24910428,17396147,17289582,22343915,16116422,16720839,18285517,20347428,20347429,18174376 Q9NW38 O15360 FANCL FANCA 0.973 17396147,16474167,17289582,20347428,20347429,22705371,18174376,18550849,22343915,16116422,16720839,12973351,21975120 Q9NW38 Q96B02 FANCL UBE2W 0.814 19549727,21229326,19111657 Q9NW38 Q9BRK4 FANCL LZTS2 0.454 25416956 Q9NW38 Q9BTP7 FANCL FAAP24 0.21 17289582 Q9NW38 Q9BXW9 FANCL FANCD2 0.523 24623813,21775430 Q9UKT9 Q9NW38 IKZF3 FANCL 0.454 25416956 Q9NW38 P46379 FANCL BAG6 0.21 24981174

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 STRA13 FANCL MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database BMPR1B FANCL MI:0045 experimental interaction detection MI:0461 interaction database UBD FANCL MI:0045 experimental interaction detection MI:0461 interaction database FANCG FANCL MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database FANCA FANCL MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database USP1 FANCL MI:0362 inference MI:1106 pathways database ERCC1 FANCL MI:0362 inference MI:1106 pathways database UBB FANCL MI:0362 inference MI:1106 pathways database UBC FANCL MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database PCNA FANCL MI:0045 experimental interaction detection MI:0461 interaction database RPA2 FANCL MI:0362 inference MI:1106 pathways database RPA1 FANCL MI:0362 inference MI:1106 pathways database GRN FANCL MI:0045 experimental interaction detection MI:0461 interaction database CTNNB1 FANCL MI:0045 experimental interaction detection MI:0461 interaction database RPA3 FANCL MI:0362 inference MI:1106 pathways database TGFBR1 FANCL MI:0045 experimental interaction detection MI:0461 interaction database TMEM33 FANCL MI:0362 inference MI:0461 interaction database SUMO2 FANCL MI:0045 experimental interaction detection MI:0461 interaction database RPS27A FANCL MI:0362 inference MI:1106 pathways database UBA52 FANCL MI:0362 inference MI:1106 pathways database FANCC FANCL MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database ACVR1 FANCL MI:0045 experimental interaction detection MI:0461 interaction database RBL2 FANCL MI:0045 experimental interaction detection MI:0461 interaction database FAAP100 FANCL MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database TFCP2 FANCL MI:0045 experimental interaction detection MI:0461 interaction database ATR FANCL MI:0362 inference MI:1106 pathways database HES1 FANCL MI:0045 experimental interaction detection MI:0461 interaction database PPP1R7 FANCL MI:0045 experimental interaction detection MI:0461 interaction database E2F4 FANCL MI:0045 experimental interaction detection MI:0461 interaction database FAAP20 FANCL MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database DCLRE1A FANCL MI:0362 inference MI:1106 pathways database POLN FANCL MI:0362 inference MI:1106 pathways database GGN FANCL MI:0362 inference MI:0461 interaction database RBM45 FANCL MI:0045 experimental interaction detection MI:0461 interaction database SLX4 FANCL MI:0362 inference MI:1106 pathways database CCDC36 FANCL MI:0045 experimental interaction detection MI:0461 interaction database FANCM FANCL MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database APITD1 FANCL MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database FANCB FANCL MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database DOCK8 FANCL MI:0045 experimental interaction detection MI:0461 interaction database ATRIP FANCL MI:0362 inference MI:1106 pathways database ERCC4 FANCL MI:0362 inference MI:1106 pathways database EME1 FANCL MI:0362 inference MI:1106 pathways database UBE2W FANCL MI:0045 experimental interaction detection MI:0461 interaction database MUS81 FANCL MI:0362 inference MI:1106 pathways database SLX1A FANCL MI:0362 inference MI:1106 pathways database LZTS2 FANCL MI:0045 experimental interaction detection MI:0461 interaction database FAAP24 FANCL MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database KIFC3 FANCL MI:0045 experimental interaction detection MI:0461 interaction database FANCD2 FANCL MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database FANCE FANCL MI:0362 inference MI:1106 pathways database UBE2T FANCL MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database FANCF FANCL MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database EIF4ENIF1 FANCL MI:0045 experimental interaction detection MI:0461 interaction database FANCI FANCL MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database FANCL CHCHD3 MI:0045 experimental interaction detection MI:0461 interaction database FANCL RIMBP3 MI:0045 experimental interaction detection MI:0461 interaction database FANCL IKZF3 MI:0045 experimental interaction detection MI:0461 interaction database FANCL SSX2IP MI:0045 experimental interaction detection MI:0461 interaction database FANCL FAN1 MI:0362 inference MI:1106 pathways database FANCL ZBTB32 MI:0362 inference MI:1106 pathways database