PTM - CPLM Gene Name UniProt ID Type Position Code TNFAIP3; OTUD7C P21580 Ubiquitination 722 K TNFAIP3; OTUD7C P21580 Ubiquitination 643 K TNFAIP3; OTUD7C P21580 Ubiquitination 520 K TNFAIP3; OTUD7C P21580 Ubiquitination 541 K TNFAIP3; OTUD7C P21580 Ubiquitination 131 K TNFAIP3; OTUD7C P21580 Ubiquitination 676 K TNFAIP3; OTUD7C P21580 Ubiquitination 66 K TNFAIP3; OTUD7C P21580 Ubiquitination 355 K TNFAIP3; OTUD7C P21580 Ubiquitination 424 K TNFAIP3; OTUD7C P21580 Ubiquitination 81 K TNFAIP3; OTUD7C P21580 Ubiquitination 301 K TNFAIP3; OTUD7C P21580 Ubiquitination 715 K TNFAIP3; OTUD7C P21580 Ubiquitination 354 K

PTM - dbPAF Gene Name UniProt ID Position Type Species TNFAIP3; OTUD7C P21580 179 T Homo sapiens(Human) TNFAIP3; OTUD7C P21580 306 Y Homo sapiens(Human) TNFAIP3; OTUD7C P21580 321 T Homo sapiens(Human) TNFAIP3; OTUD7C P21580 322 T Homo sapiens(Human) TNFAIP3; OTUD7C P21580 376 S Homo sapiens(Human) TNFAIP3; OTUD7C P21580 381 S Homo sapiens(Human) TNFAIP3; OTUD7C P21580 454 T Homo sapiens(Human) TNFAIP3; OTUD7C P21580 459 S Homo sapiens(Human) TNFAIP3; OTUD7C P21580 466 S Homo sapiens(Human) TNFAIP3; OTUD7C P21580 480 S Homo sapiens(Human) TNFAIP3; OTUD7C P21580 537 S Homo sapiens(Human) TNFAIP3; OTUD7C P21580 568 S Homo sapiens(Human) TNFAIP3; OTUD7C P21580 573 S Homo sapiens(Human) TNFAIP3; OTUD7C P21580 575 S Homo sapiens(Human) TNFAIP3; OTUD7C P21580 578 S Homo sapiens(Human) TNFAIP3; OTUD7C P21580 592 S Homo sapiens(Human) TNFAIP3; OTUD7C P21580 597 T Homo sapiens(Human) TNFAIP3; OTUD7C P21580 614 Y Homo sapiens(Human) TNFAIP3; OTUD7C P21580 617 T Homo sapiens(Human) TNFAIP3; OTUD7C P21580 625 T Homo sapiens(Human) TNFAIP3; OTUD7C P21580 631 Y Homo sapiens(Human) TNFAIP3; OTUD7C P21580 645 S Homo sapiens(Human) TNFAIP3; OTUD7C P21580 647 T Homo sapiens(Human) TNFAIP3; OTUD7C P21580 649 S Homo sapiens(Human) TNFAIP3; OTUD7C P21580 673 Y Homo sapiens(Human) TNFAIP3; OTUD7C P21580 699 S Homo sapiens(Human) TNFAIP3; OTUD7C P21580 729 S Homo sapiens(Human) TNFAIP3; OTUD7C P21580 778 Y Homo sapiens(Human)

PTM - PhosphositePlus UniProt ID MOD_RSD Type SITE_+/-7_AA P21580 K81-ac Acetylation QATLESQkkLNWCRE P21580 T118-p Phosphorylation YMWGVQDtDLVLRkA P21580 S128-p Phosphorylation VLRkALFstLkETDT P21580 T129-p Phosphorylation LRkALFstLkETDTR P21580 T179-p Phosphorylation IKMASTDtPMARSGL P21580 Y306-p Phosphorylation KEKLLKEyLMVIEIP P21580 T321-p Phosphorylation VQGWDHGttHLINAA P21580 T322-p Phosphorylation QGWDHGttHLINAAK P21580 S376-p Phosphorylation AQNPMEPsVPQLsLM P21580 S381-p Phosphorylation EPsVPQLsLMDVKCE P21580 S423-p Phosphorylation NKLPKLNskPGPEGL P21580 T454-p Phosphorylation AWNPEEStGGPHsAP P21580 S459-p Phosphorylation EStGGPHsAPPTAPs P21580 S466-p Phosphorylation sAPPTAPsPFLFSET P21580 S480-p Phosphorylation TTAMKCRsPGCPFTL P21580 S537-p Phosphorylation RTFNGICsTCFkRTT P21580 S565-p Phosphorylation SCHQRSKsDPsRLVR P21580 S568-p Phosphorylation QRSKsDPsRLVRsPs P21580 S573-p Phosphorylation DPsRLVRsPsPHsCH P21580 S575-p Phosphorylation sRLVRsPsPHsCHRA P21580 S578-p Phosphorylation VRsPsPHsCHRAGND P21580 S592-p Phosphorylation DAPAGCLsQAARtPG P21580 T597-p Phosphorylation CLsQAARtPGDRTGT P21580 Y614-p Phosphorylation CRKAGCVyFGtPENk P21580 T617-p Phosphorylation AGCVyFGtPENkGFC P21580 T625-p Phosphorylation PENkGFCtLCFIEyR P21580 Y631-p Phosphorylation CtLCFIEyRENkHFA P21580 S645-p Phosphorylation AAASGkVsPtAsRFQ P21580 T647-p Phosphorylation ASGkVsPtAsRFQNT P21580 S649-p Phosphorylation GkVsPtAsRFQNTIP P21580 Y673-p Phosphorylation GSTMFEGyCQkCFIE P21580 S699-p Phosphorylation TEEQLRSsQRRDVPR P21580 S729-p Phosphorylation kNILACRsEELCMEC P21580 Y778-p Phosphorylation GNAKCNGyCNECFQF P21580 K81-ub Ubiquitination QATLESQkkLNWCRE P21580 K82-ub Ubiquitination ATLESQkkLNWCREV P21580 K124-ub Ubiquitination DtDLVLRkALFstLk P21580 K131-ub Ubiquitination kALFstLkETDTRNF P21580 K424-ub Ubiquitination KLPKLNskPGPEGLP P21580 K520-ub Ubiquitination TRHLDPGkCQACLQD P21580 K541-ub Ubiquitination GICsTCFkRTTAEAS P21580 K621-ub Ubiquitination yFGtPENkGFCtLCF P21580 K635-ub Ubiquitination FIEyRENkHFAAASG P21580 K643-ub Ubiquitination HFAAASGkVsPtAsR P21580 K676-ub Ubiquitination MFEGyCQkCFIEAQN P21580 K715-ub Ubiquitination TQSTSRPkCARASCk P21580 K722-ub Ubiquitination kCARASCkNILACRs

PTM - dbPTM UniProt ID Position Code Type Resources References P21580 459 S Phosphorylation Swiss-Prot 1010711 19690332 P21580 575 S Phosphorylation Swiss-Prot 1010711 17081983 P21580 459 S Phosphorylation PhosphoELM.10011 18669648 P21580 568 S Phosphorylation PhosphoELM.10011 17081983 P21580 575 S Phosphorylation PhosphoELM.10011 17081983 P21580 645 S Phosphorylation PhosphoELM.10011 17081983 P21580 520 K Ubiquitylation Phosphositeplus.1010730 21906983 P21580 541 K Ubiquitylation Phosphositeplus.1010730 21906983 P21580 715 K Ubiquitylation Phosphositeplus.1010730 21906983 P21580 722 K Ubiquitylation Phosphositeplus.1010730 21890473;21906983 P21580 81 K Ubiquitylation Phosphositeplus.1010730 21906983 P21580 381 S Phosphorylation Phosphositeplus.1010730 17709380 P21580 459 S Phosphorylation Phosphositeplus.1010730 19276368;19690332 P21580 466 S Phosphorylation Phosphositeplus.1010730 19276368 P21580 568 S Phosphorylation Phosphositeplus.1010730 17081983 P21580 573 S Phosphorylation Phosphositeplus.1010730 20068231;20363803 P21580 575 S Phosphorylation Phosphositeplus.1010730 20068231;20363803 P21580 578 S Phosphorylation Phosphositeplus.1010730 20068231 P21580 645 S Phosphorylation Phosphositeplus.1010730 19415658 P21580 454 T Phosphorylation Phosphositeplus.1010730 19276368 P21580 614 Y Phosphorylation Phosphositeplus.1010730 20090780 P21580 631 Y Phosphorylation Phosphositeplus.1010730 20090780 P21580 673 Y Phosphorylation Phosphositeplus.1010730 20090780 P21580 778 Y Phosphorylation Phosphositeplus.1010730 20090780 P21580 459 S Phosphorylation HPRD 9.0 18669648 P21580 573 S Phosphorylation HPRD 9.0 20068231 P21580 575 S Phosphorylation HPRD 9.0 17081983,20068231 P21580 578 S Phosphorylation HPRD 9.0 20068231 P21580 645 S Phosphorylation HPRD 9.0 19415658,20068231 P21580 649 S Phosphorylation HPRD 9.0 17081983 P21580 321 T Phosphorylation HPRD 9.0 19413330 P21580 322 T Phosphorylation HPRD 9.0 19413330 P21580 306 Y Phosphorylation HPRD 9.0 19413330 P21580 575 S Phosphorylation SysPTM 1.1 17081983 P21580 649 S Phosphorylation SysPTM 1.1 17081983

PTM - HPRD Symbol Position Code Type References TNFAIP3 306 Y Phosphorylation 19413330 TNFAIP3 321 T Phosphorylation 19413330 TNFAIP3 322 T Phosphorylation 19413330 TNFAIP3 459 S Phosphorylation 18669648 TNFAIP3 573 S Phosphorylation 20068231 TNFAIP3 575 S Phosphorylation 17081983,20068231 TNFAIP3 578 S Phosphorylation 20068231 TNFAIP3 645 S Phosphorylation 19415658,20068231 TNFAIP3 649 S Phosphorylation 17081983

PTM - Phospho.ELM UniProt Position Code PMIDs Kinase Source Type P21580 459 S 18669648 HTP Phosphorylation P21580 568 S 17081983 HTP Phosphorylation P21580 645 S 17081983 HTP Phosphorylation P21580 575 S 17081983 HTP Phosphorylation

PTM - UniProt UniProt ID Position Type PMIDs P21580 2 N-acetylalanine 22814378 P21580 459 Phosphoserine 19690332 P21580 575 Phosphoserine 24275569 P21580 645 Phosphoserine 23186163

PTM - PHOSIDA Symbol Accession Code Position Surrounding Sequence Type TNFAIP3 IPI00009448 S 568 RSKSDPpSRLVRSP phosphorylation TNFAIP3 IPI00009448 S 573 PSRLVRpSPSPHSC phosphorylation TNFAIP3 IPI00009448 S 575 RLVRSPpSPHSCHR phosphorylation TNFAIP3 IPI00009448 S 578 RSPSPHpSCHRAGN phosphorylation TNFAIP3 IPI00009448 S 645 AASGKVpSPTASRF phosphorylation

PTM - BioGRID Entrez Gene BioGRID ID Position Code Type PMIDs 7128 112983 - K Ubiquitination 21139048 7128 112983 - K Ubiquitination 21890473 7128 112983 - K Ubiquitination 21906983 7128 112983 - K Ubiquitination 22505724 7128 112983 - K Ubiquitination 21963094 7128 112983 - K Ubiquitination 23000965 7128 112983 - K Ubiquitination 24008839 7128 112983 - K Ubiquitination 25015289 7128 112983 - K Ubiquitination 25165885 7128 112983 - K Ubiquitination 25147182 7128 112983 - K Ubiquitination 14748687

PTM - mUbiSiDa Gene Name Species Ubiquitination Site Ubiquitination Sequence Evidence PMID TNFAIP3 Homo sapiens (Human) 722 "722,CARASCKNILACR" 722:21890473 TNFAIP3 Homo sapiens (Human) 715; 81; 541; 722; 520 "715,QSTSRPKCARASC; 81,ATLESQKKLNWCR; 541,ICSTCFKRTTAEA; 722,CARASCKNILACR; 520,RHLDPGKCQACLQ" "715:21906983; 81:21906983; 541:21906983; 722:21890473,21906983; 520:21906983" TNFAIP3 Homo sapiens (Human) 81 "81,ATLESQKKLNWCR" 81:21906983