Disease associated variation - ClinVar Allele ID Type Name RS#dbSNP Phenotype IDs Chromosome Start Stop Reference Alternate 45883 single nucleotide variant WDR11, PHE1150LEU -1 MedGen:C3540450,OMIM:614858 na -1 -1 na na 45884 single nucleotide variant NM_018117.11(WDR11):c.1303G>A (p.Ala435Thr) 318240760 MedGen:C3540450,OMIM:614858;MedGen:CN221809 10 122630690 122630690 G A 45884 single nucleotide variant NM_018117.11(WDR11):c.1303G>A (p.Ala435Thr) 318240760 MedGen:C3540450,OMIM:614858;MedGen:CN221809 10 120871178 120871178 G A 45885 single nucleotide variant WDR11, HIS690GLN -1 MedGen:C4016965 na -1 -1 na na 79729 single nucleotide variant NM_018117.11(WDR11):c.1183C>T (p.Arg395Trp) 201051480 MedGen:CN221809 10 122626269 122626269 C T 79729 single nucleotide variant NM_018117.11(WDR11):c.1183C>T (p.Arg395Trp) 201051480 MedGen:CN221809 10 120866757 120866757 C T 79730 single nucleotide variant NM_018117.11(WDR11):c.1343G>A (p.Arg448Gln) 144440500 MedGen:CN221809 10 122630730 122630730 G A 79730 single nucleotide variant NM_018117.11(WDR11):c.1343G>A (p.Arg448Gln) 144440500 MedGen:CN221809 10 120871218 120871218 G A 79731 single nucleotide variant NM_018117.11(WDR11):c.2070T>A (p.His690Gln) 318240761 MedGen:CN221809 10 122646297 122646297 T A 79731 single nucleotide variant NM_018117.11(WDR11):c.2070T>A (p.His690Gln) 318240761 MedGen:CN221809 10 120886785 120886785 T A 79732 single nucleotide variant NM_018117.11(WDR11):c.2932A>C (p.Lys978Gln) 144531702 MedGen:CN221809 10 122663559 122663559 A C 79732 single nucleotide variant NM_018117.11(WDR11):c.2932A>C (p.Lys978Gln) 144531702 MedGen:CN221809 10 120904047 120904047 A C 79733 single nucleotide variant NM_018117.11(WDR11):c.3450T>G (p.Phe1150Leu) 139007744 MedGen:CN221809 10 122666300 122666300 T G 79733 single nucleotide variant NM_018117.11(WDR11):c.3450T>G (p.Phe1150Leu) 139007744 MedGen:CN221809 10 120906788 120906788 T G 247040 single nucleotide variant NM_018117.11(WDR11):c.1306A>G (p.Ile436Val) 34602786 MedGen:CN169374 10 120871181 120871181 A G 247040 single nucleotide variant NM_018117.11(WDR11):c.1306A>G (p.Ile436Val) 34602786 MedGen:CN169374 10 122630693 122630693 A G

Disease associated variation - GWASdb Chr Pos SNP ID(dbSNP 142) Ref Alt Ori SNP ID P-value Drug Name Drug Anno GWAS Trait HPO ID DO ID AA Type Trait or Drug 10 122657199 rs10788126 A G rs10788126 1.15E-07 NICOTINE|BUPROPION NICOTINIC AGONISTS|ANTIDEPRESSIVE AGENTS, SECOND-GENERATION Smoking cessation HPOID:0000707 DOID:0050742 G intron GWASdb_drug 10 122658017 rs6585674 C T rs6585674 2.55E-05 NICOTINE|BUPROPION NICOTINIC AGONISTS|ANTIDEPRESSIVE AGENTS, SECOND-GENERATION Smoking cessation HPOID:0000707 DOID:0050742 C intron GWASdb_drug 10 122665459 rs3740307 C G rs3740307 5.99E-05 PROPYLTHIOURACIL RECEPTORS, G-PROTEIN-COUPLED|TASTE RECEPTORS, TYPE 2 Taste perception HPOID:0000223 DOID:0050155 C cds-synon GWASdb_drug 10 122667022 rs1530116 T G rs1530116 1.10E-04 NICOTINE|BUPROPION NICOTINIC AGONISTS|ANTIDEPRESSIVE AGENTS, SECOND-GENERATION Smoking cessation HPOID:0000707 DOID:0050742 A intron GWASdb_drug 10 122617341 rs11199603 A G rs11199603 8.31E-05 Suicide attempts in bipolar disorder HPOID:0007302 DOID:3312 A intron GWASdb_trait 10 122631105 rs11199612 C T rs11199612 8.72E-05 Suicide attempts in bipolar disorder HPOID:0007302 DOID:3312 C intron GWASdb_trait 10 122632418 rs11199613 T C rs11199613 8.75E-05 Suicide attempts in bipolar disorder HPOID:0007302 DOID:3312 T intron GWASdb_trait 10 122633421 rs12355108 C T rs12355108 8.78E-05 Suicide attempts in bipolar disorder HPOID:0007302 DOID:3312 C cds-synon GWASdb_trait 10 122634987 rs12355961 G A rs12355961 8.87E-05 Suicide attempts in bipolar disorder HPOID:0007302 DOID:3312 G intron GWASdb_trait 10 122649482 rs2289337 A G rs2289337 1.00E-05 Cognitive performance HPOID:0100543 DOID:1561 T cds-synon GWASdb_trait 10 122655472 rs11199632 C T rs11199632 9.51E-05 Suicide attempts in bipolar disorder HPOID:0007302 DOID:3312 T intron GWASdb_trait 10 122656643 rs12355611 A C rs12355611 9.66E-05 Suicide attempts in bipolar disorder HPOID:0007302 DOID:3312 A intron GWASdb_trait 10 122657199 rs10788126 A G rs10788126 1.15E-07 Smoking cessation HPOID:0000707 DOID:0050742 G intron GWASdb_trait 10 122658017 rs6585674 C T rs6585674 2.55E-05 Smoking cessation HPOID:0000707 DOID:0050742 C intron GWASdb_trait 10 122665459 rs3740307 C G rs3740307 5.99E-05 Taste perception HPOID:0000223 DOID:0050155 C cds-synon GWASdb_trait 10 122667022 rs1530116 T G rs1530116 1.10E-04 Smoking cessation HPOID:0000707 DOID:0050742 A intron GWASdb_trait

Disease associated variation - OMIM Ensembl_gene_ID Approved Gene Symbol MIM Number ENSG00000120008.15 WDR11 606417