PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus APAF1 ELAVL1 19322201 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP G GP GP G APAF1 ENDOV 26186194 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G APAF1 TRIAP1 15735003 hprd,biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G HIP1 APAF1 16979168 hprd exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP G GP GP GP GP GP G APAF1 HSPA4 22143029,10934467 biogrid exp GP GP G G GP GP G G GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G APAF1 FAS 9267021 hprd exp GP GP G G G GP G G GP GP G GP GP G GP GP G GP G GP GP G G GP G GP GP G APAF1 HSP90AA1 15001356,10934467 biogrid exp GP GP G G G GP G G GP G G G G G G G GP G G G GP G G G G G G GP G APAF1 YWHAE 22246185,doi:10.1038/emboj.2011.491 mint,intact exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G APAF1 SHMT2 22658674 biogrid exp GP GP G G GP GP G G GP G GP GP GP GP G GP GP GP GP G GP GP GP G GP GP GP GP G APAF1 FEM1B 10764728 hprd exp GP GP G G GP GP G GP GP G GP GP GP G G GP GP GP GP G GP GP GP GP GP G GP GP G APAF1 TOP1 12549820 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G APAF1 HSPA1A, HSPA1B 10934467 hprd,mint,intact exp P P P P P P P P P P P P P P P P P P P P P P APAF1 CASP4 9539746, 25402006, 23023127, 21836163, 16082366 hprd,biogrid exp, ortho, pred GP GP G GP P G G GP GP GP GP GP G GP P G GP G GP GP GP G GP G GP P G APAF1 PPP1CA 17274640, 25402006, 21836163 innatedb,hprd,biogrid,intact exp, ortho, pred GP GP G G GP GP G G GP G GP G GP GP G GP GP G GP G GP GP GP G GP GP GP GP G APAF1 CASP9 19337385,19494828,9390557,19698783,15262985,20829884,11113115,19118655,9488720,9837928,10206961,11242052,9922454,10376594,16352606,9539746,21827945, 25402006, 23023127, 21836163, 16082366 innatedb,hprd,biogrid,i2d,mint,intact,dip exp, ortho, pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G APAF1 BCL2L10 9829980,9878060,10486928, 25402006, 21836163 hprd exp, pred P P P P P P P P P P P P P APAF1 CYCS 10206961,12147322,9267021, 25402006, 21836163 hprd,biogrid,intact exp, pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G APAF1 BCL2L1 12963020,9539746,9488720, 25402006, 21836163 hprd,biogrid exp, pred G GP G G GP GP G G G G GP GP G GP G GP GP G G G G G GP G GP G GP GP G APAF1 XIAP 11242052,19698783,12181739,11230124, 25402006 innatedb,biogrid exp, pred GP GP G G G GP G GP GP G GP GP GP GP G GP GP G GP G G GP GP G GP G GP GP G APAF1 APIP 15262985, 25402006, 21836163 hprd,biogrid exp, pred G GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP G GP GP G APAF1 CASP3 12874265,21827945,11550094, 25402006, 21836163, 16082366 innatedb,hprd,mint,intact exp, pred GP G G G GP G G GP G G G GP GP G GP G G GP G GP G G G GP GP GP GP G APAF1 NLRP1 11113115,17418785, 25402006, 23023127, 21836163 hprd,biogrid exp, pred G GP G G G GP G G GP G GP GP GP G G GP GP G G GP GP GP GP GP G GP GP G APAF1 AVEN 10949025, 25402006, 21836163 hprd,biogrid,mint,intact exp, pred GP GP P P G GP GP G P GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G APAF1 CASP8 9539746, 25402006, 23023127, 21836163, 16082366 hprd,biogrid exp, pred GP GP G GP P GP GP GP GP GP GP G GP P GP P G GP GP GP P GP GP GP GP G APAF1 APAF1 23023127 ortho, pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G APAF1 MALT1 16082366 pred G G GP G G G G G G GP G G G G G G G G G G G G GP G APAF1 NLRP9 25402006 pred GP P G P P P G P G P G GP P GP GP GP P P P P APAF1 CASP12 25402006 pred P P P P P P P P P P P P P P P P P P APAF1 BAD 25402006 pred GP GP G P GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP G GP GP GP GP G APAF1 CARD18 16082366 pred GP G G P P P P P G G P P P APAF1 CARD8 25402006, 23023127, 16082366 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G APAF1 TACC3 23023127 pred P G GP P GP P P GP GP P P P P P GP GP GP GP APAF1 PPP1R10 25402006 pred GP GP G G G GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP GP GP G GP GP G APAF1 MYD88 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G APAF1 NIF3L1 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G APAF1 BAZ1B 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G APAF1 NLRP10 25402006, 21836163 pred P P G P P P P P P P P P P P P P P P P P P P P APAF1 PSME3 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G APAF1 BIK 25402006 pred P P P P P P P P GP P P P GP GP P GP P GP P APAF1 BNIP3L 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G APAF1 BCL2L12 21836163 pred GP GP G GP P GP GP GP GP GP GP G GP P GP GP GP GP GP GP GP GP GP GP G APAF1 BMF 25402006 pred GP GP G GP P P GP GP GP GP GP G GP P GP GP G GP GP GP P GP GP GP P G APAF1 IKBIP 21836163 pred GP GP G GP P GP GP P P GP GP G P P GP GP G GP GP P P GP GP GP GP APAF1 LMTK2 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G APAF1 SMO 23023127 pred G GP G G GP GP G GP GP G GP GP GP G G GP GP GP GP G GP GP GP GP GP G GP GP G APAF1 NLRP3 23023127, 16082366 pred P G GP P P P P P P P P APAF1 BCL2L11 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G APAF1 NLRP14 25402006 pred P P G GP P P P P P P P GP G P P P P P APAF1 DEDD2 23023127 pred GP GP G G GP GP G G GP G GP G G GP G GP GP GP GP G GP GP GP G GP GP GP GP G APAF1 SNCA 25402006 pred G G G G GP GP G GP GP G GP G G G G GP GP G G G G G G G GP G GP G APAF1 RIPK2 25402006, 23023127, 16082366 pred GP GP G G GP GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP GP GP G G GP G APAF1 BCL2 25402006, 23023127 pred G G G G GP GP G G GP G GP G G GP G G GP GP G G GP GP G G G GP G G G APAF1 HSPA8 25402006 pred P P P P P P P P P P P P P P P P APAF1 PFN1 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G APAF1 APP 25402006 pred G GP G G GP GP G G GP G G G G G G GP GP G GP G GP GP G G GP G G GP G APAF1 CDKN1A 25402006 pred GP GP G G GP G G G GP G G G GP G G GP G G G G GP G G G GP G G GP G APAF1 CFLAR 25402006, 16082366 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G APAF1 MAPK14 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP G GP GP GP GP GP GP G APAF1 TRAF2 25402006 pred P P P P P P P P P P P P P P P P P P P GP GP P APAF1 DEDD 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G APAF1 SIVA1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G APAF1 BIRC6 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G APAF1 IKBKG 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G APAF1 NLRP13 25402006 pred P P P P GP P P P P GP P P P P P P GP P P P P APAF1 GTF2H1 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G APAF1 TIA1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G APAF1 BIRC7 25402006, 21836163 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP P GP GP GP GP GP GP G APAF1 RB1 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G APAF1 VIM 25402006 pred GP GP G G GP GP G G GP G GP GP GP GP G G GP GP GP G G G G G G GP G GP G APAF1 PMAIP1 25402006 pred G P G G P P GP P P G G G GP P P G G GP P P GP G GP P G APAF1 NEK2 25402006 pred P G G P P GP P P GP P P P G P P GP P P GP APAF1 TNFRSF1A 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G APAF1 BCL10 23023127, 16082366 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G APAF1 XAF1 25402006 pred G GP G G GP GP G GP GP G GP GP G G G GP GP GP P G GP G GP G GP G GP GP G APAF1 ITSN1 23023127 pred G GP G G G GP G GP GP G GP GP GP GP G GP GP G G G GP G GP GP GP G GP GP G APAF1 LEF1 23023127 pred G G G G GP GP G GP G GP GP GP G G GP G G G G G G GP G G G APAF1 NLRP4 25402006 pred P P P P P P P P P P P P P P P P P P GP APAF1 GTF2H2 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G APAF1 DDB2 23023127 pred GP GP G G GP GP G G GP G GP GP GP GP G GP GP GP GP G GP G GP GP G GP GP G APAF1 CHEK1 25402006 pred G G G GP APAF1 LAMTOR5 21836163 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G APAF1 LAMC1 23023127 pred GP G G G G GP G GP GP G GP GP GP G G GP GP GP GP G GP GP GP GP GP GP GP GP G APAF1 NLRP7 25402006, 21836163 pred P P G G GP P P P P P P P GP P P P P P P P P P P GP APAF1 NAIP 16082366 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G P G P GP GP P GP GP GP GP G APAF1 E2F1 23023127 pred P GP G G GP GP G GP GP G GP GP GP GP GP GP GP GP G P P GP P GP P GP GP G APAF1 BAK1 25402006 pred GP GP G G GP G G GP GP G GP GP GP GP G GP G G GP G GP GP GP G GP GP GP GP G APAF1 DIABLO 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G APAF1 CARD6 23023127, 16082366 pred GP GP G GP G GP GP G GP GP GP G G G G GP GP G GP GP GP GP G G GP P G APAF1 NLRP12 25402006 pred GP G G GP GP G GP GP G GP GP GP GP G GP GP GP P G GP GP GP GP GP GP GP P APAF1 BID 25402006 pred G G G GP G G GP GP G G GP GP GP G GP G G GP G G GP G GP GP GP GP APAF1 CASP8AP2 21836163 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G APAF1 CYB5A 25402006 pred G GP G G GP G G G G G GP GP GP G G GP G G GP G G G G G GP G GP GP G APAF1 BNIP3 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G APAF1 PAK2 25402006 pred GP GP G G G GP G G GP G GP GP GP GP G GP GP GP G G GP G GP GP GP GP GP G G APAF1 CASP2 25402006, 23023127, 16082366 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G APAF1 CARD14 16082366 pred GP G GP G GP P G GP GP P GP P GP G GP G GP GP GP P P GP G APAF1 CARD9 23023127, 16082366 pred G GP P P P G P P GP P P APAF1 NLRC4 25402006, 23023127, 16082366 pred P P G GP P P P P P GP P P P P P P P G P P APAF1 CASP7 25402006, 16082366 pred GP GP G G G GP G G GP G GP GP GP GP G GP GP GP GP G GP GP GP G GP G GP GP G APAF1 ACSL5 21836163 pred GP GP G G G G G G GP G GP GP GP G G GP G G GP G G G G G GP G GP GP G APAF1 CARD16 23023127, 16082366 pred G G G G P G GP G GP GP G G G G P GP P GP GP GP P G G G P APAF1 CASP1 25402006, 16082366 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP G GP GP G APAF1 TP63 23023127 pred GP G G G G G G G G G G G G G G G G G G GP GP G G G G G CASP12 APAF1 25402006 pred APAF1 BIRC5 25402006 pred P G GP P GP GP P G GP P P GP GP GP APAF1 TP53 25402006, 23023127 pred G G G G G G G G G G G G G G G GP G G G G GP G G G GP G G GP G APAF1 MCL1 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G APAF1 CSTF1 23023127 pred GP P G GP P P P P P P P G GP P GP P P GP P GP GP P P GP APAF1 CASP14 25402006, 16082366 pred G G G APAF1 CRADD 21836163, 16082366 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP G GP GP G GP GP G APAF1 AR 25402006 pred GP G G G G G G G G G G G G G G G G G G G G G G G GP G APAF1 NCOA3 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G APAF1 BNIPL 25402006 pred GP P P P P P GP GP P G P P P P P GP GP P P P P APAF1 PLEK 23023127 pred G G G G GP GP G G G G G G GP GP G G GP G G G G G G G G G G G G APAF1 AKT1 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G APAF1 DCC 25402006 pred P P P GP P P G P P P P P GP P P P P P P P P P APAF1 AIFM1 25402006 pred GP GP G G G GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP G GP GP GP GP G APAF1 IRAK3 23023127 pred GP GP G GP P GP GP P P GP GP G P P P G P GP P P GP GP GP P APAF1 MAGED1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G APAF1 PTBP1 21836163 pred GP GP G G GP GP G G GP G GP G GP GP G GP GP GP GP G GP GP GP G GP GP GP GP G APAF1 FOXL2 23023127 pred G G G G G APAF1 PIP5K1A 21836163 pred GP GP G G GP GP G G GP G GP GP GP GP G G GP GP GP G GP GP G GP G GP GP GP G APAF1 NR3C1 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G APAF1 VASP 23023127 pred GP GP G G GP GP G G GP G GP GP GP GP G GP GP GP GP G GP GP GP G GP GP GP GP G APAF1 MAP3K7 25402006 pred GP GP G G G GP G G GP G G GP GP G G G GP G GP G GP GP G G G G GP GP G APAF1 CARD17 23023127 pred APAF1 DNAJA3 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G APAF1 NOD1 23023127, 21836163, 16082366 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G APAF1 PYCARD 25402006, 23023127, 16082366 pred GP GP G G GP P G G GP G P GP GP GP G GP P GP GP G GP GP GP P GP GP GP P G APAF1 EIF2AK2 25402006 pred GP GP G G GP GP G G GP G GP G GP GP G GP GP G GP G GP GP GP G GP G GP GP G APAF1 GSPT1 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G APAF1 PSEN2 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G APAF1 CECR2 23023127 pred GP GP G G G GP G P GP G P GP GP P G GP GP P GP G GP P GP GP GP P P GP APAF1 NLRP5 25402006 pred P P P P P P P P P P GP G P P P P P P APAF1 BIRC2 25402006, 23023127, 16082366 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP G GP GP GP GP GP GP G APAF1 MAP3K2 25402006 pred G GP G G G GP G GP GP G GP GP G G G GP GP G G G GP GP GP GP GP G GP GP G APAF1 CASP10 25402006 pred GP GP G G GP GP G GP GP G GP G GP GP G GP GP GP GP G GP GP G G GP GP GP GP G APAF1 HSPD1 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP G GP GP GP GP G APAF1 CARD10 23023127, 16082366 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G APAF1 BBC3 25402006 pred APAF1 NGFR 23023127 pred GP G G P P G G G G G G P G G G APAF1 NOD2 25402006, 23023127, 16082366 pred P G GP P P P GP P P P P P P P P P GP P HRK APAF1 25402006 pred P P G P GP P P P P P GP P P G P P P P P P DFFA APAF1 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G APAF1 ZEB2 23023127 pred G G G G GP GP G GP G G GP GP GP GP G G GP G G G G G G GP G G G APAF1 BRCA1 25402006 pred P P G GP P P P P P P P GP P P P P P P P P P P GP APAF1 TRAF1 25402006 pred G G G G GP GP G G GP G GP G G GP G G GP G G G G G G G GP G G G APAF1 CASP6 25402006, 16082366 pred GP G G GP G G GP GP G G GP G GP GP GP P GP GP GP G GP G APAF1 COX4I2 25402006 pred G GP G G G G G GP GP G GP G GP G G G G GP GP G GP GP GP GP G G GP GP G APAF1 PTEN 25402006 pred GP GP G G GP GP G G GP G GP G GP GP G GP GP G GP G GP G GP G GP GP GP GP G APAF1 HSPB1 25402006 pred GP GP G G GP G G GP GP G GP GP GP G G GP G GP GP G GP GP GP GP GP G GP GP G APAF1 NOL3 23023127, 16082366 pred GP GP G GP G GP GP G GP GP GP GP G G GP G GP G GP GP GP GP G G GP P G APAF1 TRAF3 25402006 pred G GP G G GP GP G G G G GP GP GP GP G GP GP GP GP G GP G GP G GP G GP GP G APAF1 STK4 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G APAF1 NLRP8 25402006 pred G G G G G GP G GP P G GP G G GP GP P G GP G GP G GP G G APAF1 TP73 23023127 pred G G G G G APAF1 BCL2L2 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G APAF1 HTRA2 25402006 pred GP GP G G GP GP G G GP G GP GP GP G G GP GP G GP G GP GP GP G GP G GP GP G APAF1 GZMB 25402006 pred G G GP G G GP G G G GP G G APAF1 NLRP2 21836163 pred P P G P P G P GP G GP P GP GP G GP GP GP GP G GP GP GP P GP GP GP GP APAF1 NLRP11 25402006 pred P P P P P P P P G TNFRSF10A APAF1 23023127 pred GP G G G G GP G GP GP G GP G GP G G GP GP G G G GP G GP G GP G GP GP G APAF1 BAX 25402006, 23023127 pred P P G GP P P GP GP P GP P GP P GP P G P GP P P GP GP GP P G APAF1 BIRC3 25402006, 23023127, 16082366 pred GP G GP G G GP P GP G GP G GP G GP P G GP GP GP GP GP APAF1 HOXD13 23023127 pred G APAF1 CASP5 25402006, 23023127, 16082366 pred P P P P P P P P P P P P P P P P P P P P P P

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants O14727 P55211 - 15829969 - X 2 O14727 ion exchange chromatography 10692394 association C 3 O14727 G4XXL9 x-ray crystallography 16271896 association X 2 O14727 P55211 x-ray crystallography 10376594 direct interaction X 2 O14727 P55211 biochemical 10376594 direct interaction X 2 O14727 cosedimentation in solution 20462491 physical association C 3 O14727 electron microscopy 20462491 physical association C 3 O14727 P55211 x-ray crystallography 10376594 direct interaction X 2 O14727 Q9NQS1 coimmunoprecipitation 10949025 physical association X 2 O14727 Q9NQS1 coimmunoprecipitation 10949025 physical association X 2 O14727 P42574 experimental interaction detection 11550094 cleavage reaction X 2 O14727 P55211 molecular sieving 19494828 physical association X 2 O14727 P62258 pull down 22246185 physical association X 2 O14727 P62258 pull down 22246185 physical association X 2 O14727 P55211 x-ray crystallography 9390557 direct interaction X 2 O14727 P55211 coimmunoprecipitation 9390557 physical association X 2 O14727 P55211 pull down 9390557 direct interaction X 2 O14727 P55211 pull down 9922454 physical association X 2 O14727 pull down 21536655 association C 4 O14727 pull down 10206961 association C 3 O14727 cosedimentation 10206961 physical association C 3 O14727 cosedimentation 10206961 physical association C 3 O14727 G4XXL9 pull down 10206961 physical association X 2 O14727 A8K5I0 coimmunoprecipitation 10934467 physical association X 2 O14727 A8K5I0 coimmunoprecipitation 10934467 physical association X 2 O14727 P62136 anti bait coimmunoprecipitation 17274640 physical association X 2 O14727 P62136 antibody array 17274640 physical association X 2 O14727 G4XXL9 coimmunoprecipitation 9267021 physical association X 2 O14727 G4XXL9 coimmunoprecipitation 9267021 physical association X 2 O14727 Q9Z0F3 coimmunoprecipitation 9829980 physical association X 2 O14727 Q9Z0F3 two hybrid 9829980 physical association X 2 O14727 electron microscopy 21827945 physical association C 3 O14727 electron microscopy 21827945 physical association C 3 O14727 cosedimentation through density gradient 21827945 physical association C 3 O14727 cosedimentation through density gradient 21827945 physical association C 3 O14727 electron microscopy 21827945 physical association C 3 O14727 electron microscopy 21827945 physical association C 3 O14727 protease assay 21827945 cleavage reaction C 4 O14727 protease assay 21827945 cleavage reaction C 4 O14727 protease assay 21827945 cleavage reaction C 4 O14727 protease assay 21827945 cleavage reaction C 4 O14727 protease assay 21827945 cleavage reaction C 4 O14727 protease accessibility laddering 21827945 direct interaction C 4 O14727 P28301 psi-mi:"MI:0096"(-) 21536655 psi-mi:"MI:0914" X 2 O14727 P28301 psi-mi:"MI:0096"(-) 21536655 psi-mi:"MI:0914" X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B APAF1 CYCS MI:0096(pull down)|MI:0019(coimmunoprecipitation)|MI:0019(coimmunoprecipitation)|MI:0493(in vivo)|MI:0004(affinity chromatography technology)|MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down)|MI:0493(in vivo) 10206961,9267021 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|-|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0914(association)|- (intact)|(intact)|(intact)|MI:0468(hprd)|(biogrid)|(intact)|(intact)|(intact)|MI:0468(hprd) UniProt_66207|UniProt_135062|UniProt_135061|HPRD_27920|BIOGRID_105441|UniProt_66209|UniProt_66208|UniProt_66206|HPRD_39664 bait|prey|prey|-|prey|neutral component|neutral component|bait|- prey|bait|bait|-|bait|neutral component|neutral component|prey|- APAF1 YWHAE MI:0096(pull down)|MI:0096(pull down) 22246185 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (intact)|(intact) UniProt_122177|UniProt_122176 bait|bait prey|prey APAF1 NLRP1 MI:0493(in vivo)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 11113115 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) -|MI:0915(physical association)|MI:0914(association) MI:0468(hprd)|(biogrid)|(biogrid) HPRD_10514|BIOGRID_101200|BIOGRID_101203 -|bait|bait -|prey|prey APAF1 PPP1CA MI:0493(in vivo)|MI:0678(antibody array)|MI:0004(affinity chromatography technology)|MI:0678(antibody array) 17274640 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) -|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) MI:0468(hprd)|(intact)|(biogrid)|(intact) HPRD_32130|UniProt_89883|BIOGRID_200075|UniProt_89909 -|bait|prey|prey -|prey|bait|bait APAF1 XIAP MI:0492(in vitro)|MI:0415(enzymatic study)|MI:0415(enzymatic study)|MI:0004(affinity chromatography technology) 11230124,11242052,19698783 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) -|MI:0915(physical association)|MI:0403(colocalization)|MI:0915(physical association) MI:0468(hprd)|(biogrid)|(biogrid)|(biogrid) HPRD_40462|BIOGRID_212169|BIOGRID_212167|BIOGRID_216059 -|bait|bait|prey -|prey|prey|bait APAF1 TOP1 MI:0686(unspecified method) 12549820 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_225820 prey bait APAF1 BCL2L10 MI:0493(in vivo)|MI:0493(in vivo) 9829980,9878060 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) -|- MI:0468(hprd)|MI:0468(hprd) HPRD_40612|HPRD_10511 -|- -|- APAF1 HSPA4 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 10934467,22143029 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0914(association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid)|(biogrid) BIOGRID_101478|BIOGRID_101475|BIOGRID_101477|BIOGRID_167182 prey|bait|bait|prey bait|prey|prey|bait HIP1 APAF1 MI:0493(in vivo)|MI:0493(in vivo) 16979168 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) -|- MI:0468(hprd)|MI:0468(hprd) HPRD_39780|HPRD_31660 -|- -|- APAF1 UBC MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 21139048,21890473,21906983 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid) BIOGRID_172093|BIOGRID_175798|BIOGRID_181213 prey|prey|prey bait|bait|bait APAF1 CASP8 MI:0018(two hybrid)|MI:0004(affinity chromatography technology) 9539746 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) -|MI:0915(physical association) MI:0468(hprd)|(biogrid) HPRD_9778|BIOGRID_103082 -|bait -|prey APAF1 APIP MI:0096(pull down)|MI:0493(in vivo)|MI:0096(pull down)|MI:0096(pull down) 15262985 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|-|MI:0915(physical association)|MI:0407(direct interaction) (biogrid)|MI:0468(hprd)|(biogrid)|(biogrid) BIOGRID_85957|HPRD_10512|BIOGRID_85955|BIOGRID_85954 bait|-|prey|bait prey|-|bait|prey APAF1 ELAVL1 MI:0096(pull down) 19322201 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_187859 prey bait APAF1 FAS MI:0493(in vivo) 9267021 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) - MI:0468(hprd) HPRD_24564 - - APAF1 TRIAP1 MI:0493(in vivo) 15735003 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) - MI:0468(hprd) HPRD_30480 - - APAF1 HSPA1A MI:0019(coimmunoprecipitation)|MI:0493(in vivo)|MI:0019(coimmunoprecipitation)|MI:0019(coimmunoprecipitation)|MI:0019(coimmunoprecipitation)|MI:0019(coimmunoprecipitation)|MI:0019(coimmunoprecipitation) 10934467 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|-|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (intact)|MI:0468(hprd)|MI:0471(mint)|MI:0471(mint)|MI:0471(mint)|(intact)|MI:0471(mint) UniProt_67335|HPRD_35264|MINT_56451|MINT_85482|MINT_85483|UniProt_67334|MINT_56450 bait|-|bait|bait|bait|bait|bait prey|-|prey|prey|prey|prey|prey APAF1 FEM1B MI:0493(in vivo) 10764728 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) - MI:0468(hprd) HPRD_10513 - - APAF1 CASP9 MI:0493(in vivo)|MI:0492(in vitro)|MI:0493(in vivo)|MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down)|MI:0493(in vivo)|MI:0114(x-ray crystallography)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0401(biochemical)|MI:0096(pull down)|MI:0114(x-ray crystallography)|MI:0004(affinity chromatography technology)|MI:0415(enzymatic study)|MI:0114(x-ray crystallography)|MI:0114(x-ray crystallography)|MI:0493(in vivo)|MI:0114(x-ray crystallography)|MI:0071(molecular sieving)|MI:0096(pull down)|MI:0114(x-ray crystallography)|MI:0114(x-ray crystallography)|MI:0114(x-ray crystallography)|MI:0114(x-ray crystallography)|MI:0114(x-ray crystallography)|MI:0004(affinity chromatography technology)|MI:0114(x-ray crystallography)|MI:0415(enzymatic study)|MI:0029(cosedimentation through density gradient)|MI:0004(affinity chromatography technology)|MI:0071(molecular sieving)|MI:0029(cosedimentation through density gradient)|MI:0114(x-ray crystallography)|MI:0029(cosedimentation through density gradient)|MI:0029(cosedimentation through density gradient)|MI:0071(molecular sieving)|MI:0029(cosedimentation through density gradient)|MI:0029(cosedimentation through density gradient) 10206961,10376594,11113115,11230124,11242052,15262985,16979168,19494828,19698783,21827945,9390557,9488720,9539746,9878060,9922454 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) -|-|-|MI:0915(physical association)|MI:0915(physical association)|MI:0914(association)|-|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0403(colocalization)|MI:0407(direct interaction)|MI:0915(physical association)|-|MI:0407(direct interaction)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) MI:0468(hprd)|MI:0468(hprd)|MI:0468(hprd)|(intact)|(intact)|(intact)|MI:0468(hprd)|(intact)|(biogrid)|(biogrid)|MI:0465(dip)|(intact)|MI:0471(mint)|(biogrid)|(biogrid)|(intact)|(intact)|MI:0468(hprd)|MI:0471(mint)|(intact)|(biogrid)|MI:0471(mint)|MI:0471(mint)|MI:0471(mint)|MI:0471(mint)|MI:0471(mint)|(biogrid)|(intact)|(biogrid)|(intact)|(biogrid)|MI:0471(mint)|(intact)|MI:0471(mint)|(intact)|(intact)|MI:0471(mint)|(intact)|(intact) HPRD_39780|HPRD_40462|HPRD_40612|UniProt_66209|UniProt_66208|UniProt_66206|HPRD_39664|UniProt_66713|BIOGRID_104480|BIOGRID_96279|DIP_53494|UniProt_136058|MINT_56759|BIOGRID_216060|BIOGRID_212166|UniProt_135507|UniProt_135506|HPRD_10507|MINT_85846|UniProt_101752|BIOGRID_85956|MINT_85847|MINT_85848|MINT_56761|MINT_49275|MINT_56760|BIOGRID_103080|UniProt_135505|BIOGRID_212168|UniProt_115712|BIOGRID_101201|MINT_72067|UniProt_115711|MINT_81279|UniProt_115714|UniProt_115713|MINT_42072|UniProt_115716|UniProt_115715 -|-|-|neutral component|neutral component|bait|-|neutral component|bait|prey|-|bait|unspecified role|prey|bait|bait|bait|-|unspecified role|neutral component|bait|bait|bait|bait|unspecified role|bait|bait|unspecified role|bait|neutral component|prey|neutral component|neutral component|unspecified role|neutral component|neutral component|neutral component|neutral component|neutral component -|-|-|neutral component|neutral component|prey|-|neutral component|prey|bait|-|prey|unspecified role|bait|prey|prey|prey|-|unspecified role|neutral component|prey|prey|prey|prey|unspecified role|prey|prey|unspecified role|prey|neutral component|bait|neutral component|neutral component|unspecified role|neutral component|neutral component|neutral component|neutral component|neutral component APAF1 CASP3 MI:0492(in vitro)|MI:0045(experimental interaction detection)|MI:0492(in vitro)|MI:0045(experimental interaction detection)|MI:0045(experimental interaction detection) 11230124,11550094 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) -|MI:0194(cleavage reaction)|-|MI:0194(cleavage reaction)|MI:0194(cleavage reaction) MI:0468(hprd)|MI:0471(mint)|MI:0468(hprd)|MI:0471(mint)|(intact) HPRD_40462|MINT_78110|HPRD_25980|MINT_48683|UniProt_69329 -|unspecified role|-|unspecified role|unspecified role -|unspecified role|-|unspecified role|unspecified role APAF1 AVEN MI:0019(coimmunoprecipitation)|MI:0019(coimmunoprecipitation)|MI:0019(coimmunoprecipitation)|MI:0019(coimmunoprecipitation)|MI:0019(coimmunoprecipitation)|MI:0019(coimmunoprecipitation)|MI:0493(in vivo)|MI:0018(two hybrid) 10949025 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|-|MI:0915(physical association) MI:0471(mint)|MI:0471(mint)|(intact)|(intact)|MI:0471(mint)|MI:0471(mint)|MI:0468(hprd)|(biogrid) MINT_57194|MINT_57193|UniProt_66781|UniProt_66782|MINT_77305|MINT_77304|HPRD_10509|BIOGRID_107825 bait|bait|bait|bait|bait|bait|-|prey prey|prey|prey|prey|prey|prey|-|bait APAF1 BCL2L1 MI:0004(affinity chromatography technology)|MI:0018(two hybrid)|MI:0004(affinity chromatography technology) 9488720,9539746 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|-|MI:0915(physical association) (biogrid)|MI:0468(hprd)|(biogrid) BIOGRID_104481|HPRD_6107|BIOGRID_103088 bait|-|prey prey|-|bait APAF1 HSP90AA1 MI:0686(unspecified method)|MI:0004(affinity chromatography technology) 10934467,15001356 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_218836|BIOGRID_101476 prey|bait bait|prey APAF1 CASP4 MI:0004(affinity chromatography technology)|MI:0018(two hybrid) 9539746 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|- (biogrid)|MI:0468(hprd) BIOGRID_103081|HPRD_10508 bait|- prey|-

PPI - HINT Gene A Gene B PMID Method Quality APAF1 HSPA4 10934467,10934467,22143029,10934467 0096,0401,0004,0004 LC APAF1 CASP9 9390557,9390557,9390557,11113115,19698783,20829884,10376594,15262985,9488720,11242052,11242052,10206961,10206961,9539746,10376594,9390557,9922454 0019,0004,0114,0004,0004,0096,0401,0096,0004,0401,0004,0096,0027,0004,0114,0096,0096 LC APAF1 XIAP 11242052,19698783,11242052 0004,0004,0401 LC APAF1 CYCS 10206961,9267021,10206961,9267021 0096,0004,0027,0019 LC APAF1 BCL2L1 9539746,9488720,9539746,9488720 0018,0018,0004,0004 LC APAF1 ENDOV 26186194 0004 HT APAF1 ENDOV 26186194 0004 HT APAF1 HSPA4 10934467,10934467,22143029,10934467 0096,0401,0004,0004 LC APAF1 CASP9 9390557,9390557,9390557,11113115,19698783,20829884,10376594,15262985,9488720,11242052,11242052,10206961,10206961,9539746,10376594,9390557,9922454 0019,0004,0114,0004,0004,0096,0401,0096,0004,0401,0004,0096,0027,0004,0114,0096,0096 LC APAF1 XIAP 11242052,19698783,11242052 0004,0004,0401 LC APAF1 CYCS 10206961,9267021,10206961,9267021 0096,0004,0027,0019 LC APAF1 BCL2L1 9539746,9488720,9539746,9488720 0018,0018,0004,0004 LC HEL-S-103 APAF1 10934467 0019 LC APAF1 APAF1 15829969 0114 LC APAF1 HSPA1A 10934467 0019 LC APAF1 HSPA4 10934467,10934467,10934467 0096,0401,0004 LC APAF1 CASP3 21827945,11550094 0435,0045 LC APAF1 CASP9 21827945,21827945,9390557,9390557,9390557,10376594,21827945,15829969,15829969,11242052,11242052,10206961,10206961,19494828,10376594,9390557,19337385 0435,0029,0019,0004,0114,0401,0040,0071,0045,0401,0004,0096,0027,0071,0114,0096,0018 LC APAF1 PPP1CA 17274640,17274640,17274640 0004,0678,0006 LC APAF1 XIAP 11242052,12181739,11230124,11242052 0004,0059,0059,0401 LC APAF1 CYCS 10206961,9267021,10206961,16271896,9267021 0096,0004,0027,0114,0019 LC APAF1 BCL2L1 9539746,9488720,9539746,9488720,12963020 0018,0018,0004,0004,0018 LC APAF1 APIP 15262985,15262985,15262985 0018,0004,0096 LC APAF1 NLRP1 11113115,11113115 0004,0401 LC APAF1 BCL2L10 9878060,10486928,9829980 0018,0018,0018 LC APAF1 AVEN 10949025,10949025,10949025 0019,0018,0004 LC

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 HIP1 APAF1 MI:0362 inference MI:0461 interaction database APAF1 TRIAP1 MI:0045 experimental interaction detection MI:0461 interaction database APAF1 HSP90AA1 MI:0045 experimental interaction detection MI:0461 interaction database APAF1 UBC MI:0045 experimental interaction detection MI:0461 interaction database APAF1 HSPA1A MI:0045 experimental interaction detection MI:0461 interaction database APAF1 HSPA1B MI:0045 experimental interaction detection MI:0461 interaction database APAF1 TOP1 MI:0362 inference MI:0461 interaction database APAF1 HSP90B1 MI:0045 experimental interaction detection MI:0461 interaction database APAF1 LOX MI:0362 inference MI:0461 interaction database APAF1 SHMT2 MI:0045 experimental interaction detection MI:0461 interaction database APAF1 HSPA4 MI:0045 experimental interaction detection MI:0461 interaction database APAF1 PPP1CC MI:0362 inference MI:0461 interaction database APAF1 CASP3 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database APAF1 CASP4 MI:0045 experimental interaction detection MI:0461 interaction database APAF1 CASP7 MI:0362 inference MI:1106 pathways database APAF1 CASP9 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database APAF1 PPP1CA MI:0045 experimental interaction detection MI:0461 interaction database APAF1 YWHAE MI:0045 experimental interaction detection MI:0461 interaction database APAF1 XIAP MI:0045 experimental interaction detection MI:0461 interaction database APAF1 CYCS MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database APAF1 BCL2L1 MI:0045 experimental interaction detection MI:0461 interaction database APAF1 CASP8 MI:0045 experimental interaction detection MI:0461 interaction database APAF1 ELAVL1 MI:0045 experimental interaction detection MI:0461 interaction database APAF1 ENDOV MI:0045 experimental interaction detection MI:0461 interaction database APAF1 APIP MI:0045 experimental interaction detection MI:0461 interaction database APAF1 NLRP1 MI:0045 experimental interaction detection MI:0461 interaction database APAF1 BCL2L10 MI:0362 inference MI:0461 interaction database APAF1 AVEN MI:0045 experimental interaction detection MI:0461 interaction database