PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus SPOP ZBTB16 16189514 hprd,biogrid,mint,intact exp G GP G G G GP G G GP G G G GP G G G GP G GP G G GP GP G G G G GP G SPOP AR 24508459,19762545,25274033 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G GP G SPOP PIP4K2B 18218622 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G SPOP DDIT3 16189514 hprd,biogrid,mint,intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G SPOP HIF1A 24656772 intact exp G GP G G G GP G G GP G GP G GP G G G GP G GP G GP G GP G G G GP GP G SPOP PIAS1 21988832 biogrid,intact exp G GP G G G GP G G GP G GP GP GP G G G GP G GP G GP GP GP G G G GP GP G SPOP PTEN 24656772 intact exp G GP G G G GP G G GP G GP G GP G G G GP G GP G GP G GP G G G GP GP G SPOP FADD 21988832 biogrid,intact exp G GP G G G GP G G GP G GP G GP G G G GP G GP G GP G GP G G G GP GP G PIP5K1B SPOP 17353931 biogrid,intact exp G GP G G G GP G G GP G GP P GP G G G GP G GP G GP GP G G G G GP GP G SPOP RTN3 16189514 hprd,biogrid,mint,intact exp G G G G G GP G G GP G G G G G G G GP G G G G G G G G G G G G SPOP DPPA2 16189514 hprd,biogrid,mint,intact exp P G G P P P P P P GP GP P P P GP SPOP UBE2E3 19256485 biogrid exp G GP G G G GP G G GP G GP G G G G G GP G G G GP G G G G G GP GP G SPOP BRMS1 22085717 biogrid exp G GP G G G GP G G GP G GP GP GP G G G GP G GP G GP GP GP G G G GP GP G SPOP RXRB 21988832,16189514 hprd,biogrid,mint,intact exp G GP G G G GP G G GP G GP GP GP G G G GP G GP G GP GP GP G G G GP GP G SPOP DEK 25278611 biogrid exp G G G G G GP G G GP G GP GP GP G G G GP G GP G GP GP GP G G G GP GP G SPOP RTN4 26186194 biogrid exp G G G G G GP G G GP G G G G G G G GP G G G G G G G G G G GP G SPOP GDI1 17353931 biogrid,intact exp G GP G G G GP G G GP G GP GP GP G G G GP G GP G GP GP GP G G G GP GP G SPOP DUSP7 24656772 intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G SPOP NUP50 26186194 biogrid exp G GP G G G GP G G GP G GP GP GP G G G GP G GP G GP GP GP G G G GP GP G SPOP ESR1 18414007 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G SPOP SIRT2 17353931 biogrid,intact exp G GP G G G GP G G G G GP G GP G G G GP G G G G G G G G G G GP G SPOP GIT2 21988832 biogrid,intact exp G GP G G G GP G G GP G GP GP GP G G G GP G GP G GP GP GP G G G GP GP G SPOP HCST 10426994,12426564,12740575,12426565 hprd exp G G G G G GP G G GP G G G GP G G G GP G G G GP GP G G G G GP G G SPOP NCOA3 23559371,21577200 biogrid,intact exp G GP G G G GP G G GP G GP GP GP G G G GP G GP G GP GP GP G G G GP GP G SPOP ATM 24451148 biogrid exp G GP G G G GP G G GP G GP GP GP G G G GP G GP G GP GP GP G G G GP GP G SPOP BMI1 15897469 biogrid exp P P P P P P P P P P P P P SPOP KPNA6 17353931 biogrid,intact exp G GP G G G GP G G GP G GP GP GP G G G GP G GP G GP GP GP G G G GP GP G SPOP GCC1 21516116 biogrid,mint,intact exp G GP G G G GP G G GP G GP GP GP G G G GP G GP G GP GP GP G G G GP GP G SPOP SRRM1 21988832 biogrid,intact exp G GP G G G GP G G GP G GP GP GP G G G GP G GP G GP GP GP G G G GP GP G SPOP DOK2 17353931 biogrid,intact exp G G G G G G G G GP G G G G G G G G G G G G SPOP SPOP 25278611,15240113 biogrid exp, ortho G GP G G G GP G G GP G GP GP GP G G G GP G GP G GP GP GP G G G GP GP G SPOP GLI2 25204354 biogrid exp, ortho G GP G G G GP G G GP G GP GP GP G G G GP G GP G GP GP GP G G G GP GP G SPOP PDX1 15121856, 25402006 hprd exp, ortho, pred P P SPOP TRAF1 11279055, 25402006, 21836163 innatedb,hprd,biogrid,bci exp, ortho, pred G G G G G GP G G GP G GP G G G G G GP G G G G G G G G G G G SPOP H2AFY 12183056, 21836163 hprd exp, ortho, pred G GP G G G GP G G GP G GP GP GP G G G GP G GP G GP GP GP G G G GP GP G SPOP CUL3 22013077,21988832,21577200,16524876,19261606,19256485,22911784,25278611,25011449, 21836163 biogrid,intact exp, ortho, pred G GP G G G GP G G GP G GP GP GP G G G GP G GP G GP GP GP G G G GP GP G TRAF5 SPOP 25402006 bci exp, pred G GP G G G GP G G GP G GP GP GP G G G GP G GP G GP GP GP G G G GP GP G SPOP TRAF4 25402006 bci exp, pred G GP G GP G GP G GP GP GP G G G GP G GP G GP G GP G G GP GP G SPOP TRAF3 25402006 bci exp, pred G GP G G G GP G G G G GP GP GP G G G GP G GP G GP G GP G G G GP GP G SPOP TRAF2 25402006 bci exp, pred P P P P P P P P P P P G GP P SPOP MYD88 21988832,16189514,26186194, 25402006 innatedb,hprd,biogrid,mint,intact exp, pred G GP G G G GP G G GP G GP GP GP G G G GP G GP G GP GP GP G G G GP GP G SPOP DAXX 21988832,16524876,21573799,15240113, 21836163 innatedb,biogrid,intact exp, pred G GP G G G GP G G GP G GP GP GP G G G GP G GP G GP GP GP G G G GP GP G SPOP TRAF6 11279055, 25402006, 21836163 innatedb,biogrid,bci exp, pred G GP G G G G G G GP G GP GP GP G G G G G G G GP GP GP G G G GP GP G SPOP AQR ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G SPOP PAK4 ortho G GP G G G GP G G GP G GP GP GP G G G GP G GP G GP GP GP G G G GP GP G SPOP TPT1 ortho G GP G G G GP G G GP G GP G GP G G G GP G GP G GP GP GP G G G GP GP G SPOP RAP2B ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G SPOP CRNKL1 ortho G G G G G GP G G GP G G G GP G G G GP G G G G G GP G G G GP GP G SPOP CHRD ortho G GP G GP G G GP G GP GP GP G G G GP G GP G GP GP GP G G G GP P G SPOP POLR3F ortho G GP G G G GP G G GP G GP P P G G G GP G GP G GP GP GP G G G GP GP G SPOP ELOVL4 ortho G G G G G G G G SPOP GALK2 ortho G GP G G GP G G GP G GP GP G G G GP G GP G GP G GP G G G GP GP G SPOP PPM1B ortho G GP G G G GP G G GP G GP GP GP G G G GP G GP G GP GP GP G G G GP GP G SPOP RPL22 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G SPOP CAND1 ortho G GP G G G G G G GP G GP GP G G G G G G G G G G GP G G G G GP G SPOP GLI3 ortho G GP G G G GP G G GP G GP G GP G G G GP G G G GP GP G G G G GP GP G SPOP ESRRG ortho G G G G GP G G GP G GP P P G G GP G G G G GP G G G GP P G SPOP PAK1 ortho G GP G G G GP G G GP G GP GP GP G G G GP G GP G GP GP GP G G G GP GP G SPOP WDR26 ortho G GP G G G GP G G GP G GP GP GP G G G GP G GP G GP GP GP G G G GP GP G SPOP TRIO ortho G GP G G G GP G G GP G GP GP GP G G G GP G GP G GP GP GP G G G GP GP G SPOP ATP7A ortho G GP G G GP G G GP G GP GP GP G G G GP G GP G GP GP GP G G G GP GP G MAN2B1 SPOP ortho G GP G G G GP G G GP G GP GP GP G G G GP G GP G GP GP GP G G G GP GP G SPOP RPS3 25402006 ortho, pred G GP G G G GP G G GP G GP GP GP G G G GP G GP G GP GP GP G G G GP GP G SPOP KLRK1 25402006 pred P SPOP CCNL1 21836163 pred G GP G G G GP G G GP G GP G G G G G GP G GP G GP GP GP G G G GP GP G SPOP RBBP7 21836163 pred G GP G G G GP G G GP G GP GP GP G G G GP G GP G GP GP GP G G G GP GP G SPOP CASP6 25402006 pred G G G G G G GP GP G G G G G G GP P GP GP G G GP G SPOP HSPA1L 25402006 pred G P G G G G G G G G P G G G G GP G SPOP TNPO3 21836163 pred G GP G G G GP G G GP G GP GP GP G G G GP G GP G GP GP GP G G G GP GP G SPOP SRSF11 21836163 pred G GP G G G GP G G GP G GP GP GP G G G GP G GP G GP GP GP G G G GP GP G SPOP RBM23 21836163 pred G GP G G G GP G G GP G GP G GP G G G GP G GP G GP GP GP G G G GP GP G SPOP ACTG1 25402006 pred G GP G G G GP G G GP G GP GP GP G G G GP G GP G GP GP GP G G G GP GP G DHX15 SPOP 21836163 pred G GP G G G GP G G GP G GP G G G G G GP G GP G GP G G G G G GP GP G SPOP SRSF7 21836163, 16082366 pred G G G G G GP G G GP G G GP GP G G G GP G GP G GP GP GP G G G GP GP G SPOP SOX17 21836163 pred G GP G G G P G G GP GP GP GP G G G GP G GP G GP GP P G G G GP GP G SPOP BIRC2 25402006 pred G GP G G G GP G G GP G GP GP GP G G G GP G GP G GP G GP G G G GP GP G SPOP UBE2V1 25402006 pred SPOP CYLD 25402006 pred G GP G G G GP G G GP G GP GP GP G G G GP G P G GP GP GP G G G GP GP SPOP TUBB 25402006 pred G GP G G G GP G G GP G GP GP GP G G G GP G GP G GP GP GP G G G GP GP G SPOP TRAIP 25402006 pred P P P P P P P P P P P P GP SPOP MAP3K14 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PSMD12 SPOP 25402006 pred G GP G G G GP G G GP G GP GP GP G G G GP G GP G GP GP GP G G G GP GP G SPOP BIRC3 25402006 pred G G G G G GP P GP G G G G G GP P G GP G G GP GP SPOP TRIM37 25402006 pred G GP G G G GP G G GP G GP G GP G G G GP G GP G GP GP GP G G G GP GP G SPOP HSPA9 25402006 pred G GP G G G GP G G GP G GP GP GP G G G GP G GP G GP GP GP G G G GP GP G SPOP CASP10 25402006 pred G GP G G G GP G G GP G GP G GP G G G GP G GP G GP GP G G G G GP GP G SPOP C8orf4 21836163 pred G GP P G G GP GP G G G G G P G G GP GP G G G G GP G SPOP CNOT7 21836163 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G SPOP HBZ 21836163 pred G G SPOP HIVEP3 25402006 pred GP G GP G P G P P GP G G GP P G P GP GP G P P SPOP ZNF675 25402006 pred SPOP TNFRSF12A 25402006 pred G GP G G G GP G G GP G GP GP GP G G G GP G GP G GP GP GP G G GP GP G TCERG1 SPOP 21836163 pred G GP G G G GP G G GP G GP GP GP G G G GP G GP G GP GP GP G G G GP GP G SPOP SQSTM1 25402006 pred G GP G G G G G G GP G GP GP GP G G G G G GP G GP GP GP G G G GP GP G SPOP ZBTB32 21836163 pred P P P P P P P GP SPOP ETS1 21836163 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G SPOP TRADD 25402006 pred G GP G G G GP G G GP G GP G GP G G G GP G G G GP GP GP G G G GP GP G SPOP TNFRSF11A 25402006 pred G P G G P GP P P G G G P P G P G G G GP P G SPOP KLHL3 23023127 pred G GP G G G GP G G GP G GP GP GP G G G GP G GP G GP G GP G G G GP GP G SPOP EAF2 21836163 pred G GP G G G GP G G GP G GP P G G G GP GP G P GP G G G G GP GP G SPOP CIR1 21836163 pred G G G G G GP G G GP G G G GP G G G GP G GP G G GP G G G G GP G G SPOP UBA2 21836163 pred G GP G G G GP G G GP G GP GP GP G G G GP G GP G G GP GP G G G GP GP G SPOP USP7 25402006 pred G GP G G G GP G G GP G GP GP GP G G G GP G GP G GP GP GP G G G GP GP G SPOP NFX1 21836163 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G SPOP TUBA3C, TUBA3D 25402006 pred P P P P P P P P SPOP HTATIP2 21836163 pred G GP G G G GP G G GP G GP GP GP G G G GP G GP G GP GP GP G G G GP GP G SPOP RBM10 21836163 pred G GP G G G GP G G GP G GP GP GP G G G GP G P G GP GP GP G G GP P G SPOP CXXC1 21836163 pred G GP G G G GP G G GP G GP GP GP G G G GP G GP G GP GP GP G G G GP GP G SPOP TNFSF9 25402006 pred G GP G G G GP G G GP G P P GP G G G GP G GP G P P GP G G G GP GP G SPOP TNFAIP3 25402006 pred G GP G G G GP G G GP G GP GP GP G G G GP G GP G GP GP GP G G G GP GP G SPOP RANBP3 16082366 pred G GP G G G GP G G GP G GP GP GP G G G GP G GP G GP GP GP G G G GP GP G SPOP EAF1 21836163 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G SPOP DNAJA1 25402006 pred G GP G G G GP G G GP G GP GP GP G G G GP G GP G GP GP GP G G G GP GP G SPOP OTUD7B 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G SPOP NHP2L1 21836163 pred G GP G G G GP G G GP G GP GP G G G G GP G GP G GP GP GP G G G GP GP G SPOP SNW1 21836163 pred G GP G G G GP G G GP G GP GP GP G G G GP G GP G GP GP GP G G G GP GP G CASC3 SPOP 21836163 pred G GP G G G GP G G GP G GP GP GP G G G GP G GP G GP GP GP G G G GP GP G SPOP CDC40 21836163 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G SPOP NT5DC2 25402006 pred G GP G GP G G GP G GP P GP G G G GP G P G GP GP GP G GP GP G SPOP RCN2 25402006 pred G G G G G GP G G GP G G G G G G G GP G G G GP G G G G G GP GP G SPOP CLK3 21836163 pred G GP G G G GP G G GP G GP GP GP G G G GP G GP G GP GP GP G G G GP GP G SPOP FBXO4 21836163 pred G G G G G G G G G G G G G G G G G G G G G G G G G G SPOP TAB1 25402006 pred G GP G G G GP G G GP G GP GP GP G G G GP G P G GP GP GP G G G GP GP G SPOP RBM4 21836163 pred G GP G G G GP G G GP G GP GP GP G G G GP G GP G GP GP GP G G G GP GP G SPOP DGKQ 21836163 pred G GP G G G GP G G GP G GP GP GP G G G GP G GP G P GP GP G G G GP GP G SPOP PAPOLA 21836163 pred G GP G G G GP G G GP G GP GP GP G G G GP G GP G GP GP GP G G G GP GP G SPOP CD40 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G SPOP CLK2 21836163 pred G GP G G G GP G G GP G GP G GP G G G GP G GP G GP GP GP G G G GP GP G SPOP CASP8 25402006 pred G GP G G P G GP GP GP GP G G G P G P G GP GP GP G G GP GP G SPOP HSPA8 25402006 pred P P P P P P P P P P P P SPOP SRSF2 21836163 pred P P P P P P P P P P P P P SPOP U2AF1 21836163 pred G GP G G G GP G G GP G GP GP GP G G G GP G GP G GP GP GP G G G GP GP G SPOP TAF6 21836163 pred G GP G G G GP G G GP G GP GP GP G G G GP G GP G GP GP GP G G G GP GP G SPOP TUBB6 25402006 pred G GP G G G GP G G GP G GP GP GP G G G GP G GP G G GP GP G G G GP GP G SPOP PPIB 25402006 pred G GP G G G GP G G GP G GP GP GP G G G GP G GP G GP GP GP G G G GP GP G PPIH SPOP 21836163 pred G GP G G G GP G G GP GP P GP G G G GP G GP G GP G GP G G G GP GP G SPOP PHF5A 21836163 pred G GP G G G GP G G GP G GP GP GP G G G GP G GP G GP GP GP G G G GP GP G SPOP TICAM1 25402006 pred G GP G P G G GP GP GP GP G G G P G GP GP GP GP G G G GP P G CFLAR SPOP 25402006 pred G GP G G G GP G G GP G GP GP GP G G G GP G GP G GP GP GP G G G GP GP G SPOP SF3B2 21836163 pred G GP G G G GP G G GP G GP GP GP G G G GP G GP G GP GP GP G G G GP GP G SPOP CALML3 21836163 pred G GP G G G GP G G GP G GP GP GP G G G GP G GP G P GP GP G G GP GP G SPOP PI4KB 21836163 pred G GP G G G GP G G GP G GP GP GP G G G GP G GP G GP GP GP G G G GP GP G SPOP TUBB4A 25402006 pred G GP G G G GP G G GP G GP GP GP G G GP G GP G GP P GP G G G GP GP G SPOP TUBB2B 25402006 pred P G GP G GP G GP P P G G GP GP G GP GP G GP P G SPOP CLK1 21836163 pred G GP G G G GP G G GP G GP GP GP G G G GP G GP G GP GP GP G G G GP GP G SPOP UBC 21836163 pred G GP G G G GP G G GP G GP GP GP G G G GP G GP G GP GP GP G G G GP GP G SPOP SRPK1 21836163 pred G GP G G G GP G G GP G GP GP GP G G G GP G GP G GP GP GP G G G GP GP G SPOP PNN 21836163 pred G GP G G G GP G G GP G GP GP GP G G G GP G GP G GP GP GP G G G GP GP G SPOP PRPF18 21836163 pred G GP G G G GP G G GP G GP GP GP G G G GP G GP G GP GP GP G G G GP GP G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q13158 O43791 two hybrid 21988832 direct interaction X 2 Q969T4 O43791 pull down 19256485 direct interaction X 2 O43791 P35638 two hybrid 16189514 direct interaction X 2 O43791 A0A024R475 affinity chromatography technology 22013077 physical association X 2 O43791 affinity chromatography technology 18414007 physical association X 2 O43791 affinity chromatography technology 18414007 physical association X 2 O43791 A0A024R475 affinity chromatography technology 22911784 physical association X 2 O43791 P78356 two hybrid 18218622 direct interaction X 2 O43791 P78356 pull down 18218622 direct interaction X 2 O43791 P78356 affinity chromatography technology 18218622 physical association X 2 O43791 P78356 affinity chromatography technology 18218622 physical association X 2 O43791 A0A024R475 pull down 19256485 direct interaction X 2 O43791 Q9Y6Q9-5 affinity chromatography technology 23559371 physical association X 2 O43791 Q9Y6Q9-5 affinity chromatography technology 23559371 physical association X 2 O43791 A0A024R475 affinity chromatography technology 16524876 physical association X 2 O43791 A0A024R475 affinity chromatography technology 16524876 physical association X 2 O43791 A0A024R475 two hybrid 21988832 direct interaction X 2 O43791 O75925 two hybrid 21988832 direct interaction X 2 O43791 Q14161-2 two hybrid 21988832 direct interaction X 2 O43791 A0A024R475 affinity chromatography technology 25011449 physical association X 2 O43791 A0A024R475 affinity chromatography technology 25278611 physical association X 2 O43791 affinity chromatography technology 22085717 physical association X 2 O43791 affinity chromatography technology 22085717 physical association X 2 O43791 pull down 22085717 direct interaction X 2 O43791 A0A024R0G8 affinity chromatography technology 17353931 physical association X 2 O43791 O60496 affinity chromatography technology 17353931 physical association X 2 O43791 Q9Y6Q9-5 two hybrid 21577200 direct interaction X 2 O43791 Q9Y6Q9-5 affinity chromatography technology 21577200 physical association X 2 O43791 Q9Y6Q9-5 affinity chromatography technology 21577200 physical association X 2 O43791 Q9Y6Q9-5 pull down 21577200 direct interaction X 2 O43791 Q9Y6Q9-5 pull down 21577200 direct interaction X 2 O43791 A0A024R475 pull down 21577200 direct interaction X 2 O43791 Q9Y6Q9-5 enzymatic study 21577200 direct interaction X 2 O43791 A0A024R475 two hybrid 19261606 direct interaction X 2 O43791 Q7Z7J5 two hybrid 16189514 direct interaction X 2 O60684 O43791 affinity chromatography technology 17353931 physical association X 2 O43791 P28702 two hybrid 16189514 direct interaction X 2 O43791 O95197 two hybrid 16189514 direct interaction X 2 O43791 two hybrid 16189514 direct interaction X 2 O43791 affinity chromatography technology 15240113 physical association X 2 O43791 O43791 affinity chromatography technology 15240113 physical association X 2 O43791 two hybrid 21573799 direct interaction X 2 O43791 affinity chromatography technology 16524876 physical association X 2 O43791 affinity chromatography technology 16524876 physical association X 2 O43791 affinity chromatography technology 21988832 physical association X 2 O43791 affinity chromatography technology 21988832 physical association X 2 O43791 two hybrid 21988832 direct interaction X 2 O43791 P28702 two hybrid 21988832 direct interaction X 2 O43791 two hybrid 21988832 direct interaction X 2 O43791 Q8IYB3 two hybrid 21988832 direct interaction X 2 O43791 affinity chromatography technology 24508459 physical association X 2 O43791 affinity chromatography technology 24508459 physical association X 2 O43791 pull down 24508459 direct interaction X 2 O43791 A0A024R3C7 affinity chromatography technology 24451148 physical association X 2 O43791 A0A024R3C7 affinity chromatography technology 24451148 physical association X 2 O43791 P10070 affinity chromatography technology 25204354 physical association X 2 O43791 P35659 affinity chromatography technology 25278611 physical association X 2 O43791 O43791 affinity chromatography technology 25278611 physical association X 2 O43791 O43791 pull down 25278611 direct interaction X 2 O43791 affinity chromatography technology 25274033 physical association X 2 O43791 affinity chromatography technology 25274033 physical association X 2 O43791 pull down 25274033 direct interaction X 2 O43791 P35659 enzymatic study 25278611 direct interaction X 2 O43791 P35659 affinity chromatography technology 25278611 physical association X 2 O43791 P31150 affinity chromatography technology 17353931 physical association X 2 O43791 O14986 affinity chromatography technology 17353931 physical association X 2 O43791 Q9Y4K3 pull down 11279055 direct interaction X 2 O43791 two hybrid 19762545 direct interaction X 2 O43791 P35226 affinity chromatography technology 15897469 physical association X 2 O43791 A0A024R3C6 two hybrid 16189514 direct interaction X 2 P0CG48 O43791 affinity chromatography technology 18218622 physical association X 2 P0CG48 O43791 affinity chromatography technology 22053931 physical association X 2 P0CG48 O43791 affinity chromatography technology 21139048 physical association X 2 P0CG48 O43791 affinity chromatography technology 21890473 physical association X 2 P0CG48 O43791 affinity chromatography technology 21906983 physical association X 2 Q13077-2 O43791 pull down 11279055 direct interaction X 2 O43791 coimmunoprecipitation 15897469 association C 3 O43791 anti tag coimmunoprecipitation 16524876 association C 3 O43791 coimmunoprecipitation 15897469 association C 3 O43791 P35638 two hybrid 16189514 - X 2 O43791 Q9UBK5-2 in vitro 10426994,12426564,12426565,12740575 - X 2 O43791 Q9UBK5-2 in vivo 10426994,12426564,12426565,12740575 - X 2 O43791 Q7Z7J5 two hybrid 16189514 - X 2 O43791 O75367-2 two hybrid 12183056 - X 2 O43791 Q7Z7J5 two hybrid 16189514 - X 2 O43791 Q9UBK5-2 in vivo 10426994,12426564,12426565,12740575 - X 2 O43791 Q9UBK5-2 in vitro 10426994,12426564,12426565,12740575 - X 2 O43791 O75367-2 two hybrid 12183056 - X 2 O43791 P35638 two hybrid 16189514 - X 2 O95197-2 O43791 two hybrid 16189514 - X 2 O95197-2 O43791 two hybrid 16189514 - X 2 A0A0A0MS70 O43791 two hybrid 16189514 - X 2 A0A0A0MS70 O43791 two hybrid 16189514 - X 2 P52945 O43791 in vivo 15121856 - X 2 P52945 O43791 two hybrid 15121856 - X 2 P52945 O43791 two hybrid 15121856 - X 2 P52945 O43791 in vivo 15121856 - X 2 O43791 P28702 two hybrid 16189514 - X 2 O43791 A0A024R3C6 two hybrid 16189514 - X 2 O43791 P28702 two hybrid 16189514 - X 2 O43791 A0A024R3C6 two hybrid 16189514 - X 2 Q13077 O43791 in vitro 11279055 - X 2 Q13077 O43791 in vitro 11279055 - X 2 O43791 anti tag coimmunoprecipitation 21577200 association C 3 Q99836 O43791 two hybrid pooling approach 16189514 physical association X 2 Q99836 O43791 two hybrid array 21988832 physical association X 2 Q99836 O43791 confocal microscopy 21988832 colocalization X 2 Q99836 O43791 anti tag coimmunoprecipitation 21988832 physical association X 2 Q99836 O43791 pull down 21988832 physical association X 2 O43791 Q7Z7J5 two hybrid pooling approach 16189514 physical association X 2 O43791 P35638 two hybrid pooling approach 16189514 physical association X 2 O43791 Q8IXJ6 anti bait coimmunoprecipitation 17353931 physical association X 2 O43791 O60496 anti bait coimmunoprecipitation 17353931 physical association X 2 O43791 A4D0Z4 two hybrid 21516116 physical association X 2 O43791 A0A024RCS3 two hybrid 21573799 physical association X 2 O43791 A0A024R475 pull down 21577200 direct interaction X 2 O43791 O75925 two hybrid array 21988832 physical association X 2 O43791 A0A024RCS3 confocal microscopy 21988832 colocalization X 2 O43791 A0A024RCS3 anti tag coimmunoprecipitation 21988832 physical association X 2 O43791 A0A024RCS3 two hybrid array 21988832 physical association X 2 O43791 tandem affinity purification 22810585 association C 37 F6KD01 O43791 anti tag coimmunoprecipitation 24656772 physical association X 2 F6KD01 O43791 anti tag coimmunoprecipitation 24656772 physical association X 2 F6KD01 O43791 x-ray crystallography 24656772 direct interaction X 2 O60684 O43791 anti bait coimmunoprecipitation 17353931 physical association X 2 O43791 P28702 two hybrid pooling approach 16189514 physical association X 2 O43791 A0A024R3C6 two hybrid pooling approach 16189514 physical association X 2 O43791 O95197 two hybrid pooling approach 16189514 physical association X 2 O43791 P31150 anti bait coimmunoprecipitation 17353931 physical association X 2 O43791 O14986 anti bait coimmunoprecipitation 17353931 physical association X 2 O43791 P28702 two hybrid array 21988832 physical association X 2 O43791 Q14161 two hybrid array 21988832 physical association X 2 O43791 Q16829 anti tag coimmunoprecipitation 24656772 physical association X 2 O43791 Q16829 anti tag coimmunoprecipitation 24656772 physical association X 2 Q9Y6Q9 O43791 pull down 21577200 direct interaction X 2 Q9Y6Q9 O43791 anti tag coimmunoprecipitation 21577200 physical association X 2 Q9Y6Q9 O43791 anti bait coimmunoprecipitation 21577200 physical association X 2 Q9Y6Q9 O43791 pull down 21577200 direct interaction X 2 Q9Y6Q9 O43791 pull down 21577200 direct interaction X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B SPOP DDIT3 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0096(pull down)|MI:0018(two hybrid) 16189514 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) -|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) MI:0468(hprd)|(biogrid)|MI:0471(mint)|(intact)|MI:0471(mint) HPRD_20415|BIOGRID_80730|MINT_39548|UniProt_153558|MINT_68816 -|prey|prey|unspecified role|prey -|bait|bait|unspecified role|bait SPOP TRAF1 MI:0096(pull down)|MI:0492(in vitro) 11279055 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|- (biogrid)|MI:0468(hprd) BIOGRID_113927|HPRD_9632 bait|- prey|- SPOP FADD MI:0004(affinity chromatography technology)|MI:0397(two hybrid array) 21988832 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_286233|UniProt_119339 prey|unspecified role bait|unspecified role SPOP RXRB MI:0018(two hybrid)|MI:0004(affinity chromatography technology)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0096(pull down)|MI:0397(two hybrid array)|MI:0018(two hybrid) 16189514,21988832 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0407(direct interaction)|-|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid)|MI:0468(hprd)|MI:0471(mint)|(intact)|(intact)|MI:0471(mint) BIOGRID_80506|BIOGRID_286293|HPRD_20951|MINT_68497|UniProt_153339|UniProt_117453|MINT_39235 prey|prey|-|prey|unspecified role|unspecified role|prey bait|bait|-|bait|unspecified role|unspecified role|bait SPOP CUL3 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0096(pull down)|MI:0006(anti bait coimmunoprecipitation)|MI:0018(two hybrid)|MI:0397(two hybrid array)|MI:0018(two hybrid)|MI:0004(affinity chromatography technology) 16524876,19256485,19261606,21577200,21988832,22013077,22911784 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0407(direct interaction) (biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(intact)|(biogrid)|(intact)|(biogrid)|(biogrid) BIOGRID_201113|BIOGRID_275205|BIOGRID_275206|BIOGRID_209530|BIOGRID_214475|UniProt_114049|BIOGRID_146654|UniProt_119338|BIOGRID_142475|BIOGRID_287873 prey|prey|bait|prey|prey|prey|prey|unspecified role|bait|prey bait|bait|prey|bait|bait|bait|bait|unspecified role|prey|bait PIP5K1B SPOP MI:0004(affinity chromatography technology)|MI:0006(anti bait coimmunoprecipitation) 17353931 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_83586|UniProt_148823 prey|prey bait|bait SPOP ESR1 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 18414007 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_208529|BIOGRID_208528 prey|bait bait|prey SPOP GIT2 MI:0397(two hybrid array)|MI:0004(affinity chromatography technology) 21988832 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_117527|BIOGRID_287875 unspecified role|prey unspecified role|bait SPOP AR MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0018(two hybrid)|MI:0004(affinity chromatography technology) 19762545,24508459 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0407(direct interaction) (biogrid)|(biogrid)|(biogrid)|(biogrid) BIOGRID_307729|BIOGRID_307728|BIOGRID_127644|BIOGRID_307730 bait|prey|prey|prey prey|bait|bait|bait SPOP NCOA3 MI:0004(affinity chromatography technology)|MI:0006(anti bait coimmunoprecipitation)|MI:0018(two hybrid)|MI:0006(anti bait coimmunoprecipitation)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0006(anti bait coimmunoprecipitation)|MI:0004(affinity chromatography technology)|MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0006(anti bait coimmunoprecipitation)|MI:0018(two hybrid) 21577200,23559371 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0914(association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(intact)|(biogrid)|(intact)|(biogrid)|(biogrid)|(intact)|(biogrid)|(intact)|(intact)|(biogrid)|(biogrid)|(intact)|(biogrid) BIOGRID_272579|UniProt_114046|BIOGRID_142466|UniProt_114048|BIOGRID_142474|BIOGRID_142472|UniProt_114051|BIOGRID_272577|UniProt_114047|UniProt_114045|BIOGRID_143581|BIOGRID_142473|UniProt_114050|BIOGRID_142471 bait|bait|prey|bait|prey|bait|prey|prey|prey|prey|bait|bait|prey|prey prey|prey|bait|prey|bait|prey|bait|bait|bait|bait|prey|prey|bait|bait SPOP TRAF6 MI:0096(pull down) 11279055 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_113928 bait prey SPOP BMI1 MI:0004(affinity chromatography technology) 15897469 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_133127 bait prey SPOP SIRT2 MI:0006(anti bait coimmunoprecipitation)|MI:0004(affinity chromatography technology) 17353931 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (intact)|(biogrid) UniProt_146375|BIOGRID_82076 bait|bait prey|prey SPOP SRRM1 MI:0004(affinity chromatography technology)|MI:0397(two hybrid array) 21988832 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_287939|UniProt_119396 bait|unspecified role prey|unspecified role SPOP PIP4K2B MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 18218622 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction) (biogrid)|(biogrid)|(biogrid)|(biogrid) BIOGRID_214224|BIOGRID_214225|BIOGRID_214226|BIOGRID_214223 bait|bait|prey|prey prey|prey|bait|bait SPOP RTN3 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0096(pull down) 16189514 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) -|MI:0407(direct interaction)|MI:0915(physical association) MI:0468(hprd)|(biogrid)|(intact) HPRD_23954|BIOGRID_80912|UniProt_153741 -|bait|unspecified role -|prey|unspecified role SPOP NRF1 MI:0428(imaging technique) 24250222 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_296550 prey bait SPOP DAXX MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0397(two hybrid array)|MI:0018(two hybrid)|MI:0004(affinity chromatography technology)|MI:0397(two hybrid array)|MI:0096(pull down)|MI:0004(affinity chromatography technology)|MI:0397(two hybrid array)|MI:0397(two hybrid array)|MI:0004(affinity chromatography technology) 15240113,16524876,21573799,21988832 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0403(colocalization)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid)|(intact)|(biogrid)|(biogrid)|(intact)|(intact)|(biogrid)|(intact)|(intact)|(biogrid) BIOGRID_275207|BIOGRID_286264|UniProt_117005|BIOGRID_212286|BIOGRID_285349|UniProt_118774|UniProt_113992|BIOGRID_275210|UniProt_120361|UniProt_120242|BIOGRID_212036 prey|prey|unspecified role|prey|prey|unspecified role|prey|bait|neutral component|unspecified role|prey bait|bait|unspecified role|bait|bait|unspecified role|bait|prey|neutral component|unspecified role|bait SPOP HCST MI:0493(in vivo) 12740575 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) - MI:0468(hprd) HPRD_12875 - - SPOP PDX1 MI:0493(in vivo) 15121856 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) - MI:0468(hprd) HPRD_7610 - - SPOP GDI1 MI:0004(affinity chromatography technology)|MI:0006(anti bait coimmunoprecipitation) 17353931 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_83337|UniProt_145144 bait|bait prey|prey SPOP DPPA2 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0096(pull down) 16189514 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|-|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association) MI:0471(mint)|MI:0468(hprd)|(biogrid)|MI:0471(mint)|(intact) MINT_66805|HPRD_23807|BIOGRID_79364|MINT_37623|UniProt_152209 bait|-|bait|bait|unspecified role prey|-|prey|prey|unspecified role SPOP MYD88 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0397(two hybrid array)|MI:0004(affinity chromatography technology)|MI:0397(two hybrid array)|MI:0018(two hybrid)|MI:0397(two hybrid array)|MI:0397(two hybrid array)|MI:0096(pull down)|MI:0397(two hybrid array)|MI:0004(affinity chromatography technology) 16189514,21988832 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|-|MI:0407(direct interaction)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0403(colocalization)|MI:0915(physical association) MI:0471(mint)|MI:0468(hprd)|(biogrid)|(intact)|(biogrid)|(intact)|MI:0471(mint)|(intact)|(intact)|(intact)|(intact)|(biogrid) MINT_40051|HPRD_21930|BIOGRID_80988|UniProt_117314|BIOGRID_287625|UniProt_119132|MINT_69346|UniProt_120325|UniProt_120266|UniProt_153814|UniProt_120391|BIOGRID_285295 prey|-|prey|unspecified role|prey|unspecified role|prey|unspecified role|unspecified role|unspecified role|neutral component|prey bait|-|bait|unspecified role|bait|unspecified role|bait|unspecified role|unspecified role|unspecified role|neutral component|bait SPOP UBC MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0018(two hybrid) 18218622,21139048,21890473,21906983,22053931 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid) BIOGRID_172874|BIOGRID_167449|BIOGRID_176900|BIOGRID_222569|BIOGRID_214230 prey|prey|prey|prey|prey bait|bait|bait|bait|bait SPOP H2AFY MI:0018(two hybrid) 12183056 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) - MI:0468(hprd) HPRD_16058 - - SPOP PIAS1 MI:0397(two hybrid array)|MI:0004(affinity chromatography technology) 21988832 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_117526|BIOGRID_287874 unspecified role|prey unspecified role|bait SPOP KPNA6 MI:0004(affinity chromatography technology)|MI:0006(anti bait coimmunoprecipitation) 17353931 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_82852|UniProt_149078 bait|bait prey|prey SPOP DOK2 MI:0006(anti bait coimmunoprecipitation)|MI:0004(affinity chromatography technology) 17353931 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (intact)|(biogrid) UniProt_150786|BIOGRID_82653 bait|bait prey|prey SPOP GCC1 MI:0018(two hybrid) 21516116 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (intact) UniProt_114293 prey bait SPOP UBE2E3 MI:0096(pull down) 19256485 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_214479 prey bait SPOP RTN3 MI:0018(two hybrid)|MI:0018(two hybrid) 16189514 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) MI:0471(mint)|MI:0471(mint) MINT_69274|MINT_39979 bait|bait prey|prey SPOP ZBTB16 MI:0018(two hybrid)|MI:0096(pull down)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 16189514 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|-|MI:0915(physical association)|MI:0407(direct interaction) MI:0471(mint)|(intact)|MI:0468(hprd)|MI:0471(mint)|(biogrid) MINT_37169|UniProt_151794|HPRD_23699|MINT_66350|BIOGRID_78942 prey|unspecified role|-|prey|prey bait|unspecified role|-|bait|bait

PPI - HINT Gene A Gene B PMID Method Quality PIP5K1B SPOP 17353931,17353931 0006,0004 HT SPOP SPOP 25278611,25278611,15240113 0096,0004,0004 LC SPOP DOK2 17353931,17353931 0006,0004 HT SPOP KPNA6 17353931,17353931 0006,0004 HT SPOP AR 24508459,25274033,24508459,25274033 0004,0004,0096,0096 LC SPOP ERG 26344095,26344096,26344095,26344095,26344096,26344096 0096,0004,0004,0415,0096,0415 LC SPOP GDI1 17353931,17353931 0006,0004 HT SPOP PTEN 24656772,24656772,24656772 0007,0114,0997 LC SPOP CUL3 25011449,21577200,22013077,19256485,25278611,16524876,22911784 0004,0096,0004,0096,0004,0004,0004 LC SPOP STM7 17353931 0004 HT SPOP SIRT2 17353931,17353931 0006,0004 HT SPOP MYD88 21988832,21988832,21988832,26186194,21988832,21988832,21988832 0397,0663,0096,0004,0018,0004,0007 LC,HT SPOP RTN4 26186194 0004 HT SPOP DAXX 21988832,21988832,21988832,21988832,21988832,16524876,15240113 0397,0663,0007,0018,0004,0004,0004 LC SPOP NUP50 26186194 0004 HT SPOP NCOA3 21577200,21577200,21577200,21577200,21577200,21577200,23559371 0096,0007,0006,0018,0415,0004,0004 LC PIP5K1B SPOP 17353931,17353931 0006,0004 HT SPOP DOK2 17353931,17353931 0006,0004 HT SPOP KPNA6 17353931,17353931 0006,0004 HT SPOP GDI1 17353931,17353931 0006,0004 HT SPOP STM7 17353931 0004 HT SPOP SIRT2 17353931,17353931 0006,0004 HT SPOP MYD88 26186194 0004 HT SPOP RTN4 26186194 0004 HT SPOP NUP50 26186194 0004 HT SPOP SPOP 25278611,25278611,15240113 0096,0004,0004 LC SPOP AR 24508459,25274033,24508459,25274033 0004,0004,0096,0096 LC SPOP ERG 26344095,26344096,26344095,26344095,26344096,26344096 0096,0004,0004,0415,0096,0415 LC SPOP PTEN 24656772,24656772,24656772 0007,0114,0997 LC SPOP CUL3 25011449,21577200,22013077,19256485,25278611,16524876,22911784 0004,0096,0004,0096,0004,0004,0004 LC SPOP MYD88 21988832,21988832,21988832,21988832,21988832,21988832 0397,0663,0096,0018,0004,0007 LC SPOP DAXX 21988832,21988832,21988832,21988832,21988832,16524876,15240113 0397,0663,0007,0018,0004,0004,0004 LC SPOP NCOA3 21577200,21577200,21577200,21577200,21577200,21577200,23559371 0096,0007,0006,0018,0415,0004,0004 LC SPOP SPOP 22632832,23999291,19818708 0114,0114,0114 LC SPOP H2AFY PDB_3IVB,19818708,12183056 0114,0114,0018 LC SPOP PIAS1 21988832,21988832 0397,0018 HT SPOP RTN3 16189514,16189514 0398,0018 HT SPOP GLI3 26475525 0114 LC SPOP AR 19762545 0018 LC SPOP ERG 26344095,26344096,26344095,26344095,26344096,26344096 0096,0004,0004,0415,0096,0415 LC SPOP RXRB 16189514,21988832,21988832,16189514 0398,0397,0018,0018 HT SPOP DDIT3 16189514,16189514 0398,0018 HT SPOP DEK 25278611,25278611 0415,0004 LC SPOP PDX1 15121856 0018 LC SPOP PTEN 24656772,24656772,24656772 0007,0114,0997 LC SPOP PIP4K2B 18218622,18218622,18218622 0096,0004,0018 LC SPOP ZBTB16 16189514,16189514 0398,0018 HT SPOP TRAF1 11279055,11279055 0096,0059 LC SPOP FADD 21988832 0018 HT SPOP CUL3 22632832,19261606,21988832 0114,0018,0018 LC,HT SPOP GIT2 21988832,21988832 0397,0018 HT SPOP DUSP7 24656772,24656772 0007,0997 LC SPOP DPPA2 16189514,16189514 0398,0018 HT SPOP SRRM1 21988832 0018 HT SPOP GCC1 21516116 0018 HT SPOP MYD88 16189514,21988832,21988832,21988832,16189514,21988832,21988832,21988832 0398,0397,0663,0096,0018,0018,0004,0007 HT SPOP DAXX 21988832,21988832,21573799,21988832,21988832,21988832 0397,0663,0018,0007,0018,0004 HT,LC SPOP TRAF6 11279055,11279055 0096,0059 LC SPOP NCOA3 21577200,21577200,21577200,21577200,21577200,21577200 0096,0007,0006,0018,0415,0004 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q05164 O43791 HPF1 SPOP 0.332 27107014 P53202 O43791 CUL3 SPOP 0.332 27107014 O43791 O14986 SPOP PIP5K1B 0.332 17353931 Q05322 O43791 VP24 SPOP 0.126 22810585 O95197 O43791 RTN3 SPOP 0.286 16189514 P03372 O43791 ESR1 SPOP 0.376 18414007 P06401 O43791 PGR SPOP 0.376 26693071 P28702 O43791 RXRB SPOP 0.49 16189514,21988832 P35226 O43791 BMI1 SPOP 0.21 15897469 P40959 O43791 MVP1 SPOP 0.332 27107014 P51668 O43791 UBE2D1 SPOP 0.309 26344096 P62837 O43791 UBE2D2 SPOP 0.309 26344096 Q05516 O43791 ZBTB16 SPOP 0.286 16189514 Q13077 O43791 TRAF1 SPOP 0.309 11279055 Q7Z7J5 O43791 DPPA2 SPOP 0.286 16189514 Q8IYB3 O43791 SRRM1 SPOP 0.332 21988832 Q9HCU9 O43791 BRMS1 SPOP 0.569 22085717 Q9Y4K3 O43791 TRAF6 SPOP 0.309 11279055 Q8IXJ6 O43791 SIRT2 SPOP 0.332 17353931 Q9H9S0 O43791 NANOG SPOP 0.126 26687479 O60496 O43791 DOK2 SPOP 0.332 17353931 Q9NQC3 O43791 RTN4 SPOP 0.126 26186194 O60684 O43791 KPNA6 SPOP 0.332 17353931 P10070 O43791 GLI2 SPOP 0.21 25204354 Q16829 O43791 DUSP7 SPOP 0.236 24656772 P78356 O43791 PIP4K2B SPOP 0.702 18218622 P35638 O43791 DDIT3 SPOP 0.554 16189514,24990631 P10275 O43791 AR SPOP 0.872 24508459,19762545,25274033 P10071 O43791 GLI3 SPOP 0.523 26475525 P60484 O43791 PTEN SPOP 0.583 24656772 Q99836 O43791 MYD88 SPOP 0.776 16189514,21988832,26186194 O75925 O43791 PIAS1 SPOP 0.286 21988832 O43791 O43791 SPOP SPOP 0.61 25278611,15240113 P53278 O43791 P53278 SPOP 0.332 27107014 Q9UER7 O43791 DAXX SPOP 0.904 21573799,16524876,21988832,15240113 P11308 O43791 ERG SPOP 0.911 26344095,26344096 Q13618 O43791 CUL3 SPOP 0.946 21577200,16524876,19256485,25011449,21988832,22013077,19261606,22911784,25278611 Q9Y6Q9 O43791 NCOA3 SPOP 0.911 21577200,23559371 Q969T4 O43791 UBE2E3 SPOP 0.309 19256485 Q96CN9 O43791 GCC1 SPOP 0.332 21516116 P31150 O43791 GDI1 SPOP 0.332 17353931 P38340 O43791 TAE1 SPOP 0.332 27107014 P35659 O43791 DEK SPOP 0.21 25278611 Q9UKX7 O43791 NUP50 SPOP 0.126 26186194 Q14161 O43791 GIT2 SPOP 0.286 21988832 Q13315 O43791 ATM SPOP 0.376 24451148 P50548 O43791 ERF SPOP 0.454 26344095 Q13158 O43791 FADD SPOP 0.332 21988832 Q08273 O43791 HRT1 SPOP 0.332 27107014

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 MAN2B1 SPOP MI:0362 inference MI:0461 interaction database MEIS2 SPOP MI:0362 inference MI:0461 interaction database PIP5K1B SPOP MI:0045 experimental interaction detection MI:0461 interaction database SPOP AQR MI:0362 inference MI:0461 interaction database SPOP DOK2 MI:0045 experimental interaction detection MI:0461 interaction database SPOP KPNA6 MI:0045 experimental interaction detection MI:0461 interaction database SPOP CAND2 MI:0362 inference MI:0461 interaction database SPOP H2AFY MI:0362 inference MI:0461 interaction database SPOP PPM1B MI:0362 inference MI:0461 interaction database SPOP PIAS1 MI:0045 experimental interaction detection MI:0461 interaction database SPOP RTN3 MI:0045 experimental interaction detection MI:0461 interaction database SPOP PAK4 MI:0362 inference MI:0461 interaction database SPOP ABL1 MI:0362 inference MI:0461 interaction database SPOP ESR1 MI:0045 experimental interaction detection MI:0461 interaction database SPOP PGR MI:0045 experimental interaction detection MI:0461 interaction database SPOP UBB MI:0362 inference MI:1106 pathways database SPOP UBC MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database SPOP GLI2 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database SPOP GLI3 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database SPOP RAP2A MI:0362 inference MI:0461 interaction database SPOP AR MI:0045 experimental interaction detection MI:0461 interaction database SPOP ERG MI:0045 experimental interaction detection MI:0461 interaction database SPOP ESRRA MI:0362 inference MI:0461 interaction database SPOP TPT1 MI:0362 inference MI:0461 interaction database SPOP UBA1 MI:0362 inference MI:0461 interaction database SPOP RPS3 MI:0362 inference MI:0461 interaction database SPOP RXRB MI:0045 experimental interaction detection MI:0461 interaction database SPOP GDI1 MI:0045 experimental interaction detection MI:0461 interaction database SPOP CDA MI:0362 inference MI:0461 interaction database SPOP BMI1 MI:0045 experimental interaction detection MI:0461 interaction database SPOP RPL22 MI:0362 inference MI:0461 interaction database SPOP DDIT3 MI:0045 experimental interaction detection MI:0461 interaction database SPOP DEK MI:0045 experimental interaction detection MI:0461 interaction database SPOP ATP7B MI:0362 inference MI:0461 interaction database SPOP CSNK1E MI:0362 inference MI:0461 interaction database SPOP ERF MI:0045 experimental interaction detection MI:0461 interaction database SPOP UBE2D1 MI:0045 experimental interaction detection MI:0461 interaction database SPOP PDX1 MI:0362 inference MI:0461 interaction database SPOP PTEN MI:0045 experimental interaction detection MI:0461 interaction database SPOP COPS2 MI:0362 inference MI:0461 interaction database SPOP RAP2B MI:0362 inference MI:0461 interaction database SPOP ESRRG MI:0362 inference MI:0461 interaction database SPOP UBE2D2 MI:0045 experimental interaction detection MI:0461 interaction database SPOP RBX1 MI:0362 inference MI:0461,MI:1106 interaction database,pathways database SPOP RPS27A MI:0362 inference MI:1106 pathways database SPOP UBA52 MI:0362 inference MI:1106 pathways database SPOP PIP4K2B MI:0045 experimental interaction detection MI:0461 interaction database SPOP GALK2 MI:0362 inference MI:0461 interaction database SPOP ATP7A MI:0362 inference MI:0461 interaction database SPOP ZBTB16 MI:0045 experimental interaction detection MI:0461 interaction database SPOP TRAF1 MI:0045 experimental interaction detection MI:0461 interaction database SPOP GPS1 MI:0362 inference MI:0461 interaction database SPOP PAK1 MI:0362 inference MI:0461 interaction database SPOP FADD MI:0045 experimental interaction detection MI:0461 interaction database SPOP ATM MI:0045 experimental interaction detection MI:0461 interaction database SPOP CUL3 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database SPOP GIT2 MI:0045 experimental interaction detection MI:0461 interaction database SPOP NEDD8 MI:0362 inference MI:0461 interaction database SPOP HIF1A MI:0045 experimental interaction detection MI:0461 interaction database SPOP DUSP7 MI:0045 experimental interaction detection MI:0461 interaction database SPOP FAM214A MI:0362 inference MI:0461 interaction database SPOP SPOPL MI:0362 inference MI:1106 pathways database SPOP RPL22L1 MI:0362 inference MI:0461 interaction database SPOP COPS6 MI:0362 inference MI:0461 interaction database SPOP DPPA2 MI:0045 experimental interaction detection MI:0461 interaction database SPOP CAND1 MI:0362 inference MI:0461 interaction database SPOP RANBP3L MI:0362 inference MI:0461 interaction database SPOP SIRT2 MI:0045 experimental interaction detection MI:0461 interaction database SPOP SRRM1 MI:0045 experimental interaction detection MI:0461 interaction database SPOP GLIS3 MI:0362 inference MI:0461 interaction database SPOP COPS5 MI:0362 inference MI:0461 interaction database SPOP UBE2E3 MI:0045 experimental interaction detection MI:0461 interaction database SPOP GCC1 MI:0045 experimental interaction detection MI:0461 interaction database SPOP COPS8 MI:0362 inference MI:0461 interaction database SPOP MYD88 MI:0045 experimental interaction detection MI:0461 interaction database SPOP BTBD10 MI:0362 inference MI:0461 interaction database SPOP COPS4 MI:0362 inference MI:0461 interaction database SPOP NTMT1 MI:0362 inference MI:0461 interaction database SPOP CRNKL1 MI:0362 inference MI:0461 interaction database SPOP POLR3F MI:0362 inference MI:0461 interaction database SPOP CHRD MI:0362 inference MI:0461 interaction database SPOP RANBP3 MI:0362 inference MI:0461 interaction database SPOP WDR26 MI:0362 inference MI:0461 interaction database SPOP NANOG MI:0045 experimental interaction detection MI:0461 interaction database SPOP BRMS1 MI:0045 experimental interaction detection MI:0461 interaction database SPOP RTN4 MI:0045 experimental interaction detection MI:0461 interaction database SPOP H2AFY2 MI:0362 inference MI:0461 interaction database SPOP PAK7 MI:0362 inference MI:0461 interaction database SPOP COPS7A MI:0362 inference MI:0461 interaction database SPOP DAXX MI:0045 experimental interaction detection MI:0461 interaction database SPOP NUP50 MI:0045 experimental interaction detection MI:0461 interaction database SPOP COPS3 MI:0362 inference MI:0461 interaction database SPOP RAP2C MI:0362 inference MI:0461 interaction database SPOP TRAF6 MI:0045 experimental interaction detection MI:0461 interaction database SPOP SNX8 MI:0362 inference MI:0461 interaction database SPOP NCOA3 MI:0045 experimental interaction detection MI:0461 interaction database