PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus CUL1 ZBTB46 21145461 biogrid exp GP G G G G GP G GP GP G GP GP GP G G GP GP GP GP G GP P GP GP GP GP GP P G ZBTB46 RGPD5, RGPD6 26186194 biogrid exp P P P P P P P P P P P P P P P P P P P AP2A2 ZBTB46 26186194 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP P GP G GP GP GP P G MBD3 ZBTB46 26186194 biogrid exp GP GP G G GP GP G GP GP G GP G GP GP G GP GP GP G G GP G GP GP GP GP P G MTA1 ZBTB46 26186194 biogrid exp G GP G G GP GP G G GP G GP GP GP GP G GP GP GP GP G GP GP G GP G GP P G WIZ ZBTB46 26186194 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP P GP GP GP GP GP P G ZBTB46 AXIN2 19888210 i2d exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP P GP GP GP GP GP P G ZBTB46 SUFU 26186194 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G P GP GP GP G GP P GP GP GP G GP P G ZBTB46 ZBTB10 26186194 biogrid exp GP GP G P GP G GP GP G GP GP GP GP G GP GP GP GP G GP P GP GP GP GP GP P G ZBTB46 NKD1 19888210 i2d exp G G G G G P G G G G P P ZBTB46 GATAD2B 26186194 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP P G P P GP GP GP GP GP P G FBXO21 ZBTB46 26186194 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G ELAVL1 ZBTB46 19322201 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP P GP GP GP G GP P G ZBTB46 GATAD2A 26186194 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP P GP GP GP GP GP P G ZBTB46 EHMT1 26186194 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G ZBTB46 FBXW11 26186194 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G ZNF318 ZBTB46 26186194 biogrid exp G GP G G GP GP G GP GP G GP GP GP G G GP GP GP GP G GP G GP GP G GP P G PRPF8 ZBTB46 26186194 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP P GP GP GP GP GP P G ZBTB46 DDX23 26186194 biogrid exp GP GP G GP GP G P GP G GP GP GP GP G GP GP GP GP G GP P GP GP GP GP GP P G AP2A1 ZBTB46 26186194 biogrid exp GP GP G G GP GP G G GP G GP G GP GP G GP GP GP GP G GP P GP G GP GP GP P G ZBTB46 BTRC 26186194 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP P GP GP GP G GP P G ZBTB46 FBXL17 26186194 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP P GP GP GP GP GP P G ZBTB46 EHMT2 26186194 biogrid exp GP G G G G GP G GP GP G GP G G G G GP GP G G G GP P GP P GP G GP P G DESI1 ZBTB46 22370726 biogrid exp, ortho GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP P GP GP GP GP GP P G ZBTB46 KLHL11 23023127 pred P P P P P P P P P P P P P P P P P P BCL6 ZBTB46 23023127 pred G G G G GP G G G G G G G G GP G G G G G G GP G G G GP G G ZBTB46 BTBD6 23023127 pred G G G G GP G G G GP G G G G GP G GP G G G G G G GP GP G G G SOCS3 ZBTB46 23023127 pred GP GP G G GP GP G GP GP G GP GP GP G G GP GP GP GP G GP GP GP GP G GP P G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q86UZ6 P55854 affinity chromatography technology 25391492 physical association X 2 Q86UZ6 Q6ICB0 affinity chromatography technology 22370726 physical association X 2 Q86UZ6 Q6ICB0 enzymatic study 22370726 direct interaction X 2 Q86UZ6 A0A090N7U0 affinity chromatography technology 21145461 physical association X 2 Q86UZ6 A0A024R3Z2 affinity chromatography technology 22370726 physical association X 2 P0CG48 Q86UZ6 affinity chromatography technology 22370726 physical association X 2

PPI - HINT Gene A Gene B PMID Method Quality FBXO21 ZBTB46 26186194 0004 HT AP2A2 ZBTB46 26186194 0004 HT AP2A1 ZBTB46 26186194 0004 HT WIZ ZBTB46 26186194 0004 HT MBD3 ZBTB46 26186194 0004 HT CUL1 ZBTB46 21145461 0004 HT ZNF318 ZBTB46 26186194 0004 HT PRPF8 ZBTB46 26186194 0004 HT ZBTB46 GATAD2A 26186194 0004 HT ZBTB46 GATAD2B 26186194 0004 HT ZBTB46 EHMT2 26186194 0004 HT ZBTB46 Q9BRL8 26186194 0004 HT ZBTB46 DDX23 26186194 0004 HT ZBTB46 EHMT1 26186194 0004 HT ZBTB46 Q9H9H3 26186194 0004 HT ZBTB46 FBXL17 26186194 0004 HT ZBTB46 FBXW11 26186194 0004 HT ZBTB46 SUFU 26186194 0004 HT ZBTB46 BTRC 26186194 0004 HT ZBTB46 HEL161 26186194 0004 HT FBXO21 ZBTB46 26186194 0004 HT AP2A2 ZBTB46 26186194 0004 HT AP2A1 ZBTB46 26186194 0004 HT WIZ ZBTB46 26186194 0004 HT MBD3 ZBTB46 26186194 0004 HT CUL1 ZBTB46 21145461 0004 HT ZNF318 ZBTB46 26186194 0004 HT PRPF8 ZBTB46 26186194 0004 HT ZBTB46 GATAD2A 26186194 0004 HT ZBTB46 GATAD2B 26186194 0004 HT ZBTB46 EHMT2 26186194 0004 HT ZBTB46 Q9BRL8 26186194 0004 HT ZBTB46 DDX23 26186194 0004 HT ZBTB46 EHMT1 26186194 0004 HT ZBTB46 Q9H9H3 26186194 0004 HT ZBTB46 FBXL17 26186194 0004 HT ZBTB46 FBXW11 26186194 0004 HT ZBTB46 SUFU 26186194 0004 HT ZBTB46 BTRC 26186194 0004 HT ZBTB46 HEL161 26186194 0004 HT DESI1 ZBTB46 22370726,22370726 0004,0415 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q86UZ6 Q6ICB0 ZBTB46 DESI1 0.454 22370726 Q86UZ6 O94952 ZBTB46 FBXO21 0.126 26186194 Q86UZ6 O94973 ZBTB46 AP2A2 0.126 26186194 Q86UZ6 O95782 ZBTB46 AP2A1 0.126 26186194 Q86UZ6 O95785 ZBTB46 WIZ 0.126 26186194 Q86UZ6 O95983 ZBTB46 MBD3 0.126 26186194 Q86UZ6 Q13330 ZBTB46 MTA1 0.126 26186194 Q86UZ6 Q5VUA4 ZBTB46 ZNF318 0.126 26186194 Q86UZ6 Q6P2Q9 ZBTB46 PRPF8 0.126 26186194 Q86YP4 Q86UZ6 GATAD2A ZBTB46 0.126 26186194 Q8WXI9 Q86UZ6 GATAD2B ZBTB46 0.126 26186194 Q96DT7 Q86UZ6 ZBTB10 ZBTB46 0.126 26186194 Q96KQ7 Q86UZ6 EHMT2 ZBTB46 0.126 26186194 Q99666 Q86UZ6 RGPD6 ZBTB46 0.126 26186194 Q9BUQ8 Q86UZ6 DDX23 ZBTB46 0.126 26186194 Q9H9B1 Q86UZ6 EHMT1 ZBTB46 0.126 26186194 Q9UF56 Q86UZ6 FBXL17 ZBTB46 0.126 26186194 Q9UKB1 Q86UZ6 FBXW11 ZBTB46 0.126 26186194 Q9UMX1 Q86UZ6 SUFU ZBTB46 0.126 26186194 Q9Y297 Q86UZ6 BTRC ZBTB46 0.126 26186194 Q86UZ6 Q13616 ZBTB46 CUL1 0.126 21145461 Q86UZ6 Q15717 ZBTB46 ELAVL1 0.126 19322201

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 FBXO21 ZBTB46 MI:0045 experimental interaction detection MI:0461 interaction database AP2A2 ZBTB46 MI:0045 experimental interaction detection MI:0461 interaction database AP2A1 ZBTB46 MI:0045 experimental interaction detection MI:0461 interaction database WIZ ZBTB46 MI:0045 experimental interaction detection MI:0461 interaction database MBD3 ZBTB46 MI:0045 experimental interaction detection MI:0461 interaction database UBC ZBTB46 MI:0045 experimental interaction detection MI:0461 interaction database SUMO3 ZBTB46 MI:0045 experimental interaction detection MI:0461 interaction database SUMO1 ZBTB46 MI:0045 experimental interaction detection MI:0461 interaction database MTA1 ZBTB46 MI:0045 experimental interaction detection MI:0461 interaction database CUL1 ZBTB46 MI:0045 experimental interaction detection MI:0461 interaction database ELAVL1 ZBTB46 MI:0045 experimental interaction detection MI:0461 interaction database ZNF318 ZBTB46 MI:0045 experimental interaction detection MI:0461 interaction database DESI1 ZBTB46 MI:0045 experimental interaction detection MI:0461 interaction database PRPF8 ZBTB46 MI:0045 experimental interaction detection MI:0461 interaction database ZBTB46 GATAD2A MI:0045 experimental interaction detection MI:0461 interaction database ZBTB46 GATAD2B MI:0045 experimental interaction detection MI:0461 interaction database ZBTB46 ZBTB10 MI:0045 experimental interaction detection MI:0461 interaction database ZBTB46 EHMT2 MI:0045 experimental interaction detection MI:0461 interaction database ZBTB46 RGPD5 MI:0045 experimental interaction detection MI:0461 interaction database ZBTB46 DDX23 MI:0045 experimental interaction detection MI:0461 interaction database ZBTB46 EHMT1 MI:0045 experimental interaction detection MI:0461 interaction database ZBTB46 FBXL17 MI:0045 experimental interaction detection MI:0461 interaction database ZBTB46 FBXW11 MI:0045 experimental interaction detection MI:0461 interaction database ZBTB46 SUFU MI:0045 experimental interaction detection MI:0461 interaction database ZBTB46 BTRC MI:0045 experimental interaction detection MI:0461 interaction database