Mutation - TCGA Type Chromosome Start Position End Position Strand Variant Classification Variant Type Reference Allele Tumor_seq Allele 1 Tumor_seq Allele 2 Tumor Sample Barcode Matched Norm Sample Barcode Genome Change cDNA Change Codon Change Protein Change BLCA 19 59067557 59067557 + Missense_Mutation SNP C C T TCGA-FD-A6TD-01A-51D-A339-08 TCGA-FD-A6TD-10A-21D-A339-08 g.chr19:59067557C>T c.451G>A c.(451-453)Gag>Aag p.E151K BLCA 19 59067596 59067596 + Splice_Site SNP C C G TCGA-G2-AA3B-01A-11D-A391-08 TCGA-G2-AA3B-10A-01D-A394-08 g.chr19:59067596C>G c.412G>C c.(412-414)Gag>Cag p.E138Q BLCA 19 59067689 59067689 + Silent SNP G G C TCGA-ZF-A9R0-01A-11D-A38G-08 TCGA-ZF-A9R0-10A-01D-A38J-08 g.chr19:59067689G>C c.405C>G c.(403-405)ctC>ctG p.L135L BLCA 19 59068071 59068071 + Silent SNP G G C TCGA-ZF-A9R0-01A-11D-A38G-08 TCGA-ZF-A9R0-10A-01D-A38J-08 g.chr19:59068071G>C c.330C>G c.(328-330)gtC>gtG p.V110V BLCA 19 59068511 59068511 + Silent SNP C C T TCGA-4Z-AA86-01A-11D-A391-08 TCGA-4Z-AA86-10A-01D-A394-08 g.chr19:59068511C>T c.123G>A c.(121-123)ctG>ctA p.L41L BLCA 19 59069642 59069642 + Missense_Mutation SNP T T C TCGA-K4-A6FZ-01A-11D-A31L-08 TCGA-K4-A6FZ-10A-01D-A31J-08 g.chr19:59069642T>C c.107A>G c.(106-108)aAg>aGg p.K36R BLCA 19 59069644 59069644 + Silent SNP C C T TCGA-BL-A3JM-01A-12D-A21A-08 TCGA-BL-A3JM-11A-31D-A21A-08 g.chr19:59069644C>T c.105G>A c.(103-105)caG>caA p.Q35Q COAD 19 59068267 59068267 + Missense_Mutation SNP T T C TCGA-G4-6586-01A-11D-1771-10 TCGA-G4-6586-10A-01D-1771-10 g.chr19:59068267T>C c.235A>G c.(235-237)Agt>Ggt p.S79G COAD 19 59068448 59068448 + Silent SNP C C G TCGA-AA-3514-01A-02W-0831-10 TCGA-AA-3514-10A-01W-0831-10 g.chr19:59068448C>G c.186G>C c.(184-186)ctG>ctC p.L62L COAD 19 59069699 59069699 + Missense_Mutation SNP G G A TCGA-AA-3492-01A-01D-1408-10 TCGA-AA-3492-11A-01D-1408-10 g.chr19:59069699G>A c.50C>T c.(49-51)gCg>gTg p.A17V COADREAD 19 59068267 59068267 + Missense_Mutation SNP T T C TCGA-G4-6586-01A-11D-1771-10 TCGA-G4-6586-10A-01D-1771-10 g.chr19:59068267T>C c.235A>G c.(235-237)Agt>Ggt p.S79G COADREAD 19 59068448 59068448 + Silent SNP C C G TCGA-AA-3514-01A-02W-0831-10 TCGA-AA-3514-10A-01W-0831-10 g.chr19:59068448C>G c.186G>C c.(184-186)ctG>ctC p.L62L COADREAD 19 59069699 59069699 + Missense_Mutation SNP G G A TCGA-AA-3492-01A-01D-1408-10 TCGA-AA-3492-11A-01D-1408-10 g.chr19:59069699G>A c.50C>T c.(49-51)gCg>gTg p.A17V ESCA 19 59067561 59067561 + Silent SNP G G A TCGA-L5-A4OI-01A-11D-A27G-09 TCGA-L5-A4OI-11A-11D-A27G-09 g.chr19:59067561G>A c.447C>T c.(445-447)gcC>gcT p.A149A ESCA 19 59068438 59068438 + Missense_Mutation SNP G G A TCGA-LN-A49U-01A-31D-A27G-09 TCGA-LN-A49U-10A-01D-A27G-09 g.chr19:59068438G>A c.196C>T c.(196-198)Cct>Tct p.P66S GBM 19 59067682 59067682 + Splice_Site SNP C C T TCGA-28-5204-01A-01D-1486-08 TCGA-28-5204-10A-01D-1486-08 g.chr19:59067682C>T c.e5+1 GBMLGG 19 59067682 59067682 + Splice_Site SNP C C T TCGA-28-5204-01A-01D-1486-08 TCGA-28-5204-10A-01D-1486-08 g.chr19:59067682C>T c.e5+1 GBMLGG 19 59068093 59068093 + Missense_Mutation SNP T T C TCGA-DU-6402-01A-11D-1705-08 TCGA-DU-6402-10A-01D-1705-08 g.chr19:59068093T>C c.308A>G c.(307-309)aAc>aGc p.N103S HNSC 19 59067527 59067527 + Missense_Mutation SNP C C T TCGA-QK-A6IG-01A-11D-A31L-08 TCGA-QK-A6IG-10A-01D-A31J-08 g.chr19:59067527C>T c.481G>A c.(481-483)Gag>Aag p.E161K HNSC 19 59067742 59067742 + Missense_Mutation SNP C C T TCGA-UF-A7J9-01A-12D-A34J-08 TCGA-UF-A7J9-10A-01D-A34M-08 g.chr19:59067742C>T c.352G>A c.(352-354)Gac>Aac p.D118N HNSC 19 59068277 59068277 + Silent SNP C C T TCGA-CV-6962-01A-11D-1912-08 TCGA-CV-6962-10A-01D-1912-08 g.chr19:59068277C>T c.225G>A c.(223-225)aaG>aaA p.K75K HNSC 19 59068489 59068489 + Missense_Mutation SNP T T C TCGA-QK-AA3K-01A-11D-A391-08 TCGA-QK-AA3K-10A-01D-A394-08 g.chr19:59068489T>C c.145A>G c.(145-147)Atc>Gtc p.I49V LGG 19 59068093 59068093 + Missense_Mutation SNP T T C TCGA-DU-6402-01A-11D-1705-08 TCGA-DU-6402-10A-01D-1705-08 g.chr19:59068093T>C c.308A>G c.(307-309)aAc>aGc p.N103S LUAD 19 59067459 59067459 + Missense_Mutation SNP T T A TCGA-38-4632-01A-01D-1753-08 TCGA-38-4632-11A-01D-1753-08 g.chr19:59067459T>A c.549A>T c.(547-549)aaA>aaT p.K183N LUSC 19 59068153 59068153 + Frame_Shift_Del DEL C C - TCGA-33-6737-01A-11D-1817-08 TCGA-33-6737-11A-01D-1817-08 g.chr19:59068153delC c.248delG c.(247-249)ggcfs p.G83fs OV 19 59068073 59068073 + Missense_Mutation SNP C C T TCGA-25-1324-01A-01W-0490-10 TCGA-25-1324-10A-01W-0490-10 g.chr19:59068073C>T c.328G>A c.(328-330)Gtc>Atc p.V110I SKCM 19 59067503 59067503 + Missense_Mutation SNP G G A TCGA-D3-A1Q1-06A-21D-A196-08 TCGA-D3-A1Q1-10A-01D-A198-08 g.chr19:59067503G>A c.505C>T c.(505-507)Cgg>Tgg p.R169W SKCM 19 59068131 59068131 + Silent SNP G G A TCGA-EE-A29E-06A-11D-A197-08 TCGA-EE-A29E-10A-01D-A199-08 g.chr19:59068131G>A c.270C>T c.(268-270)ccC>ccT p.P90P

Mutation - ICGC Project Code Chromosome Chromosome Start Chromosome End Mutation Type Mutated from Allele Mutated to Allele Consequence Type AA Mutation CDS Mutation BLCA-US 19 59063309 59063309 single base substitution C G downstream_gene_variant BLCA-US 19 59063424 59063424 single base substitution C T downstream_gene_variant BLCA-US 19 59063429 59063429 single base substitution C T downstream_gene_variant BLCA-US 19 59063468 59063468 single base substitution C T downstream_gene_variant BLCA-US 19 59069644 59069644 single base substitution C T 5_prime_UTR_variant BLCA-US 19 59069644 59069644 single base substitution C T synonymous_variant Q35Q 105G>A BLCA-US 19 59069644 59069644 single base substitution C T upstream_gene_variant BLCA-US 19 59073565 59073565 single base substitution C T upstream_gene_variant BRCA-EU 19 59062479 59062479 deletion of <=200bp T - downstream_gene_variant BRCA-EU 19 59063849 59063849 single base substitution T G downstream_gene_variant BRCA-EU 19 59064535 59064535 single base substitution C T downstream_gene_variant BRCA-EU 19 59066071 59066071 single base substitution C G downstream_gene_variant BRCA-EU 19 59066455 59066455 single base substitution C G downstream_gene_variant BRCA-EU 19 59067564 59067564 single base substitution C A downstream_gene_variant BRCA-EU 19 59067564 59067564 single base substitution C A missense_variant E148D 444G>T BRCA-EU 19 59067564 59067564 single base substitution C A missense_variant E51D 153G>T BRCA-EU 19 59068044 59068044 single base substitution G C exon_variant BRCA-EU 19 59068044 59068044 single base substitution G C intron_variant BRCA-EU 19 59068051 59068051 single base substitution C T exon_variant BRCA-EU 19 59068051 59068051 single base substitution C T splice_region_variant BRCA-EU 19 59068716 59068716 single base substitution T C intron_variant BRCA-EU 19 59068716 59068716 single base substitution T C upstream_gene_variant BRCA-EU 19 59068760 59068760 single base substitution C T intron_variant BRCA-EU 19 59068760 59068760 single base substitution C T upstream_gene_variant BRCA-EU 19 59068970 59068970 single base substitution C G intron_variant BRCA-EU 19 59068970 59068970 single base substitution C G upstream_gene_variant BRCA-EU 19 59068974 59068974 single base substitution C T intron_variant BRCA-EU 19 59068974 59068974 single base substitution C T upstream_gene_variant BRCA-EU 19 59069180 59069180 single base substitution C T intron_variant BRCA-EU 19 59069180 59069180 single base substitution C T upstream_gene_variant BRCA-EU 19 59070632 59070632 single base substitution G C upstream_gene_variant BRCA-EU 19 59071257 59071257 single base substitution G T upstream_gene_variant BRCA-EU 19 59071598 59071598 single base substitution C T upstream_gene_variant BRCA-EU 19 59071712 59071712 single base substitution T C upstream_gene_variant BRCA-EU 19 59071761 59071761 single base substitution G C upstream_gene_variant BRCA-EU 19 59072029 59072029 single base substitution C G upstream_gene_variant BRCA-EU 19 59073054 59073054 single base substitution C G upstream_gene_variant BRCA-EU 19 59073083 59073083 single base substitution C T upstream_gene_variant BRCA-EU 19 59073204 59073204 single base substitution T C upstream_gene_variant BRCA-EU 19 59074995 59074995 single base substitution G A upstream_gene_variant BRCA-EU 19 59075210 59075210 single base substitution T C upstream_gene_variant BRCA-FR 19 59068760 59068760 single base substitution C T intron_variant BRCA-FR 19 59068760 59068760 single base substitution C T upstream_gene_variant BRCA-FR 19 59073083 59073083 single base substitution C T upstream_gene_variant BRCA-UK 19 59063849 59063849 single base substitution T G downstream_gene_variant BRCA-UK 19 59071712 59071712 single base substitution T C upstream_gene_variant BRCA-UK 19 59072029 59072029 single base substitution C G upstream_gene_variant BRCA-US 19 59063456 59063456 single base substitution C T downstream_gene_variant BRCA-US 19 59063478 59063478 single base substitution C G downstream_gene_variant BRCA-US 19 59063683 59063683 single base substitution G A downstream_gene_variant BRCA-US 19 59073966 59073966 single base substitution G A upstream_gene_variant BTCA-JP 19 59063265 59063265 single base substitution G A downstream_gene_variant BTCA-JP 19 59073747 59073747 single base substitution C A upstream_gene_variant CESC-US 19 59074078 59074078 single base substitution G T upstream_gene_variant CESC-US 19 59074503 59074503 single base substitution C T upstream_gene_variant CLLE-ES 19 59065588 59065588 single base substitution A G downstream_gene_variant CLLE-ES 19 59071098 59071115 deletion of <=200bp GCGCATGGTGTGGCACTT - upstream_gene_variant CLLE-ES 19 59071487 59071487 single base substitution A G upstream_gene_variant COAD-US 19 59065487 59065487 single base substitution G A downstream_gene_variant COAD-US 19 59068267 59068267 single base substitution T C 5_prime_UTR_variant COAD-US 19 59068267 59068267 single base substitution T C exon_variant COAD-US 19 59068267 59068267 single base substitution T C missense_variant S20G 58A>G COAD-US 19 59068267 59068267 single base substitution T C missense_variant S79G 235A>G COAD-US 19 59069641 59069641 single base substitution C A missense_variant K36N 108G>T COAD-US 19 59069641 59069641 single base substitution C A splice_region_variant COAD-US 19 59069641 59069641 single base substitution C A upstream_gene_variant COAD-US 19 59069699 59069699 single base substitution G A 5_prime_UTR_variant COAD-US 19 59069699 59069699 single base substitution G A missense_variant A17V 50C>T COAD-US 19 59069699 59069699 single base substitution G A upstream_gene_variant COAD-US 19 59073488 59073488 single base substitution T C upstream_gene_variant COAD-US 19 59073585 59073586 deletion of <=200bp CA - upstream_gene_variant COAD-US 19 59074133 59074133 single base substitution T A upstream_gene_variant COAD-US 19 59074429 59074429 single base substitution C T upstream_gene_variant COAD-US 19 59074473 59074473 single base substitution G A upstream_gene_variant COAD-US 19 59074609 59074609 single base substitution G A upstream_gene_variant COAD-US 19 59074631 59074631 single base substitution G T upstream_gene_variant COAD-US 19 59074653 59074653 single base substitution T C upstream_gene_variant COAD-US 19 59074866 59074866 single base substitution C T upstream_gene_variant COCA-CN 19 59063026 59063026 single base substitution C T downstream_gene_variant COCA-CN 19 59063771 59063771 single base substitution C T downstream_gene_variant COCA-CN 19 59065451 59065451 single base substitution G T downstream_gene_variant COCA-CN 19 59069785 59069785 single base substitution C T 5_prime_UTR_variant COCA-CN 19 59069785 59069785 single base substitution C T intron_variant COCA-CN 19 59069785 59069785 single base substitution C T upstream_gene_variant COCA-CN 19 59073456 59073456 single base substitution C T upstream_gene_variant COCA-CN 19 59073617 59073617 single base substitution G A upstream_gene_variant COCA-CN 19 59074612 59074612 single base substitution G A upstream_gene_variant COCA-CN 19 59074797 59074797 single base substitution G T upstream_gene_variant EOPC-DE 19 59066605 59066605 single base substitution C G downstream_gene_variant ESAD-UK 19 59065140 59065140 insertion of <=200bp - T downstream_gene_variant ESAD-UK 19 59066845 59066845 single base substitution C T downstream_gene_variant ESAD-UK 19 59067735 59067735 single base substitution T G downstream_gene_variant ESAD-UK 19 59067735 59067735 single base substitution T G missense_variant K120T 359A>C ESAD-UK 19 59067735 59067735 single base substitution T G missense_variant K23T 68A>C ESAD-UK 19 59067735 59067735 single base substitution T G missense_variant K61T 182A>C ESAD-UK 19 59072571 59072571 single base substitution G A upstream_gene_variant ESAD-UK 19 59073726 59073726 single base substitution G T upstream_gene_variant ESAD-UK 19 59074947 59074947 single base substitution A T upstream_gene_variant ESCA-CN 19 59063073 59063073 single base substitution G T downstream_gene_variant ESCA-CN 19 59065454 59065454 single base substitution T G downstream_gene_variant ESCA-CN 19 59067714 59067714 single base substitution G T downstream_gene_variant ESCA-CN 19 59067714 59067714 single base substitution G T missense_variant S127Y 380C>A ESCA-CN 19 59067714 59067714 single base substitution G T missense_variant S30Y 89C>A ESCA-CN 19 59067714 59067714 single base substitution G T missense_variant S68Y 203C>A GBM-US 19 59067682 59067682 single base substitution C T downstream_gene_variant GBM-US 19 59067682 59067682 single base substitution C T missense_variant V79M 235G>A GBM-US 19 59067682 59067682 single base substitution C T splice_donor_variant KIRC-US 19 59073897 59073897 single base substitution T C upstream_gene_variant KIRP-US 19 59063432 59063432 insertion of <=200bp - T downstream_gene_variant KIRP-US 19 59073766 59073766 single base substitution G T upstream_gene_variant LAML-KR 19 59073898 59073898 single base substitution A G upstream_gene_variant LAML-KR 19 59074277 59074277 single base substitution A G upstream_gene_variant LGG-US 19 59068093 59068093 single base substitution T C exon_variant LGG-US 19 59068093 59068093 single base substitution T C missense_variant N103S 308A>G LGG-US 19 59068093 59068093 single base substitution T C missense_variant N44S 131A>G LGG-US 19 59068093 59068093 single base substitution T C missense_variant N6S 17A>G LICA-CN 19 59063102 59063102 single base substitution C A downstream_gene_variant LICA-CN 19 59073794 59073794 single base substitution C G upstream_gene_variant LICA-FR 19 59066075 59066075 single base substitution A C downstream_gene_variant LICA-FR 19 59074370 59074370 single base substitution G T upstream_gene_variant LICA-FR 19 59074373 59074373 single base substitution C T upstream_gene_variant LIHC-US 19 59063031 59063031 single base substitution G T downstream_gene_variant LIHC-US 19 59074590 59074612 deletion of <=200bp CCCCGCCCCCAGTGCTGGGGCGG - upstream_gene_variant LINC-JP 19 59067291 59067291 deletion of <=200bp A - 3_prime_UTR_variant LINC-JP 19 59067291 59067291 deletion of <=200bp A - downstream_gene_variant LINC-JP 19 59067512 59067512 single base substitution G C downstream_gene_variant LINC-JP 19 59067512 59067512 single base substitution G C missense_variant R166G 496C>G LINC-JP 19 59067512 59067512 single base substitution G C missense_variant R69G 205C>G LINC-JP 19 59069608 59069608 single base substitution T G intron_variant LINC-JP 19 59069608 59069608 single base substitution T G upstream_gene_variant LINC-JP 19 59074168 59074168 single base substitution C T upstream_gene_variant LIRI-JP 19 59062220 59062231 deletion of <=200bp GATGCCTAGGGA - downstream_gene_variant LIRI-JP 19 59062427 59062427 single base substitution T C downstream_gene_variant LIRI-JP 19 59063621 59063621 single base substitution C T downstream_gene_variant LIRI-JP 19 59073796 59073796 single base substitution C T upstream_gene_variant LIRI-JP 19 59074668 59074668 single base substitution C T upstream_gene_variant LIRI-JP 19 59074892 59074892 single base substitution T C upstream_gene_variant LUSC-KR 19 59065276 59065276 single base substitution A C downstream_gene_variant LUSC-KR 19 59068319 59068319 single base substitution G A exon_variant LUSC-KR 19 59068319 59068319 single base substitution G A intron_variant LUSC-KR 19 59071006 59071006 single base substitution C T upstream_gene_variant LUSC-US 19 59063771 59063771 single base substitution C T downstream_gene_variant LUSC-US 19 59068153 59068153 deletion of <=200bp C - 5_prime_UTR_variant LUSC-US 19 59068153 59068153 deletion of <=200bp C - exon_variant LUSC-US 19 59068153 59068153 deletion of <=200bp C - frameshift_variant G24 LUSC-US 19 59068153 59068153 deletion of <=200bp C - frameshift_variant G83 LUSC-US 19 59073609 59073609 single base substitution G A upstream_gene_variant MALY-DE 19 59062569 59062569 single base substitution G A downstream_gene_variant MALY-DE 19 59062809 59062809 single base substitution C T downstream_gene_variant MALY-DE 19 59064681 59064681 single base substitution G A downstream_gene_variant MELA-AU 19 59062413 59062413 single base substitution T A downstream_gene_variant MELA-AU 19 59062416 59062416 single base substitution G T downstream_gene_variant MELA-AU 19 59062699 59062699 single base substitution C T downstream_gene_variant MELA-AU 19 59062700 59062700 single base substitution C A downstream_gene_variant MELA-AU 19 59063263 59063263 single base substitution G T downstream_gene_variant MELA-AU 19 59066080 59066080 single base substitution G A downstream_gene_variant MELA-AU 19 59066466 59066466 single base substitution C T downstream_gene_variant MELA-AU 19 59066511 59066511 single base substitution G A downstream_gene_variant MELA-AU 19 59066511 59066512 multiple base substitution (>=2bp and <=200bp) GG AA downstream_gene_variant MELA-AU 19 59066512 59066512 single base substitution G A downstream_gene_variant MELA-AU 19 59066945 59066945 single base substitution C A downstream_gene_variant MELA-AU 19 59067883 59067883 single base substitution C T downstream_gene_variant MELA-AU 19 59067883 59067883 single base substitution C T intron_variant MELA-AU 19 59067966 59067966 single base substitution G A exon_variant MELA-AU 19 59067966 59067966 single base substitution G A intron_variant MELA-AU 19 59067993 59067993 single base substitution G C exon_variant MELA-AU 19 59067993 59067993 single base substitution G C intron_variant MELA-AU 19 59068132 59068132 single base substitution G A 5_prime_UTR_variant MELA-AU 19 59068132 59068132 single base substitution G A exon_variant MELA-AU 19 59068132 59068132 single base substitution G A missense_variant P31L 92C>T MELA-AU 19 59068132 59068132 single base substitution G A missense_variant P90L 269C>T MELA-AU 19 59068251 59068251 single base substitution G A intron_variant MELA-AU 19 59068251 59068251 single base substitution G A splice_region_variant MELA-AU 19 59068566 59068566 single base substitution G A intron_variant MELA-AU 19 59068566 59068566 single base substitution G A upstream_gene_variant MELA-AU 19 59070423 59070423 single base substitution T G upstream_gene_variant MELA-AU 19 59070462 59070462 single base substitution C T upstream_gene_variant MELA-AU 19 59072430 59072430 single base substitution G A upstream_gene_variant MELA-AU 19 59072594 59072594 single base substitution C T upstream_gene_variant MELA-AU 19 59073123 59073123 single base substitution G A upstream_gene_variant MELA-AU 19 59073124 59073124 single base substitution G A upstream_gene_variant MELA-AU 19 59073212 59073212 single base substitution G T upstream_gene_variant MELA-AU 19 59073258 59073258 single base substitution G A upstream_gene_variant MELA-AU 19 59073796 59073796 single base substitution C T upstream_gene_variant MELA-AU 19 59074575 59074575 single base substitution G A upstream_gene_variant ORCA-IN 19 59065453 59065453 single base substitution T C downstream_gene_variant ORCA-IN 19 59067680 59067680 single base substitution C A downstream_gene_variant ORCA-IN 19 59067680 59067680 single base substitution C A splice_region_variant ORCA-IN 19 59067680 59067680 single base substitution C A synonymous_variant V79V 237G>T OV-AU 19 59064330 59064330 single base substitution C G downstream_gene_variant OV-AU 19 59069308 59069308 single base substitution C T intron_variant OV-AU 19 59069308 59069308 single base substitution C T upstream_gene_variant OV-AU 19 59069330 59069330 single base substitution C T intron_variant OV-AU 19 59069330 59069330 single base substitution C T upstream_gene_variant OV-AU 19 59070319 59070319 single base substitution C T 5_prime_UTR_variant OV-AU 19 59070319 59070319 single base substitution C T upstream_gene_variant OV-AU 19 59071899 59071899 single base substitution C T upstream_gene_variant OV-AU 19 59074589 59074589 single base substitution A C upstream_gene_variant PACA-AU 19 59062437 59062437 single base substitution C T downstream_gene_variant PACA-AU 19 59064356 59064356 single base substitution C T downstream_gene_variant PACA-AU 19 59065595 59065595 single base substitution C T downstream_gene_variant PACA-AU 19 59067867 59067867 single base substitution A G downstream_gene_variant PACA-AU 19 59067867 59067867 single base substitution A G intron_variant PACA-AU 19 59070878 59070878 single base substitution G A upstream_gene_variant PACA-AU 19 59074030 59074030 single base substitution C G upstream_gene_variant PACA-CA 19 59063621 59063621 single base substitution C T downstream_gene_variant PACA-CA 19 59064083 59064083 single base substitution A C downstream_gene_variant PACA-CA 19 59065145 59065145 single base substitution T C downstream_gene_variant PACA-CA 19 59070474 59070474 single base substitution G A upstream_gene_variant PACA-CA 19 59070867 59070868 deletion of <=200bp TT - upstream_gene_variant PACA-CA 19 59072650 59072650 single base substitution C T upstream_gene_variant PACA-CA 19 59073608 59073608 single base substitution C T upstream_gene_variant PACA-CA 19 59074283 59074283 single base substitution T C upstream_gene_variant PAEN-AU 19 59068841 59068841 single base substitution C G intron_variant PAEN-AU 19 59068841 59068841 single base substitution C G upstream_gene_variant PAEN-AU 19 59068893 59068893 single base substitution C G intron_variant PAEN-AU 19 59068893 59068893 single base substitution C G upstream_gene_variant PAEN-AU 19 59069293 59069293 single base substitution C G intron_variant PAEN-AU 19 59069293 59069293 single base substitution C G upstream_gene_variant PAEN-IT 19 59069005 59069005 single base substitution C G intron_variant PAEN-IT 19 59069005 59069005 single base substitution C G upstream_gene_variant PRAD-CA 19 59065063 59065063 single base substitution C T downstream_gene_variant PRAD-UK 19 59070181 59070181 single base substitution C G 5_prime_UTR_variant PRAD-UK 19 59070181 59070181 single base substitution C G upstream_gene_variant SKCA-BR 19 59066731 59066731 single base substitution G C downstream_gene_variant SKCA-BR 19 59067440 59067440 single base substitution T G 3_prime_UTR_variant SKCA-BR 19 59067440 59067440 single base substitution T G downstream_gene_variant SKCM-US 19 59067503 59067503 single base substitution G A downstream_gene_variant SKCM-US 19 59067503 59067503 single base substitution G A missense_variant R169W 505C>T SKCM-US 19 59068131 59068131 single base substitution G A 5_prime_UTR_variant SKCM-US 19 59068131 59068131 single base substitution G A exon_variant SKCM-US 19 59068131 59068131 single base substitution G A synonymous_variant P31P 93C>T SKCM-US 19 59068131 59068131 single base substitution G A synonymous_variant P90P 270C>T SKCM-US 19 59074699 59074699 single base substitution C T upstream_gene_variant STAD-US 19 59065483 59065483 single base substitution G A downstream_gene_variant STAD-US 19 59067588 59067588 single base substitution G A downstream_gene_variant STAD-US 19 59067588 59067588 single base substitution G A missense_variant T110I 329C>T STAD-US 19 59067588 59067588 single base substitution G A synonymous_variant N140N 420C>T STAD-US 19 59067588 59067588 single base substitution G A synonymous_variant N43N 129C>T STAD-US 19 59068128 59068128 deletion of <=200bp G - 5_prime_UTR_variant STAD-US 19 59068128 59068128 deletion of <=200bp G - exon_variant STAD-US 19 59068128 59068128 deletion of <=200bp G - frameshift_variant P32 STAD-US 19 59068128 59068128 deletion of <=200bp G - frameshift_variant P91 STAD-US 19 59073494 59073494 single base substitution C T upstream_gene_variant STAD-US 19 59073500 59073500 single base substitution C T upstream_gene_variant STAD-US 19 59073626 59073626 single base substitution C T upstream_gene_variant STAD-US 19 59073782 59073782 single base substitution C T upstream_gene_variant STAD-US 19 59073814 59073816 deletion of <=200bp GAG - upstream_gene_variant STAD-US 19 59074394 59074394 single base substitution C A upstream_gene_variant STAD-US 19 59074613 59074613 deletion of <=200bp C - upstream_gene_variant THCA-SA 19 59074049 59074049 insertion of <=200bp - T upstream_gene_variant UCEC-US 19 59063042 59063042 single base substitution G A downstream_gene_variant UCEC-US 19 59063080 59063080 single base substitution G A downstream_gene_variant UCEC-US 19 59063275 59063275 single base substitution G A downstream_gene_variant UCEC-US 19 59063276 59063276 single base substitution A C downstream_gene_variant UCEC-US 19 59063699 59063699 single base substitution G A downstream_gene_variant UCEC-US 19 59073792 59073794 deletion of <=200bp TCC - upstream_gene_variant UCEC-US 19 59074680 59074680 single base substitution G T upstream_gene_variant

Mutation - COSMIC Sample Name Mutation ID Mutation CDS Mutation AA Mutation Description Mutation Genome Position Mutation Strand TCGA-D7-6522-01 COSM4082482 c.420C>T p.N140N Substitution - coding silent 19:58556221-58556221 - HCC81T COSM1613013 c.496C>G p.R166G Substitution - Missense 19:58556145-58556145 - TCGA-EE-A29E-06 COSM3540829 c.270C>T p.P90P Substitution - coding silent 19:58556764-58556764 - HCT-15 COSM1681477 c.512G>A p.G171D Substitution - Missense 19:58556129-58556129 - TCGA-G4-6586-01 COSM1397353 c.235A>G p.S79G Substitution - Missense 19:58556900-58556900 - 389 COSM4427644 c.485A>T p.Q162L Substitution - Missense 19:58556156-58556156 - HCT15 COSM1681477 c.512G>A p.G171D Substitution - Missense 19:58556129-58556129 - ccRCC-71 COSM1664856 c.113T>A p.I38K Substitution - Missense 19:58557154-58557154 - TCGA-AY-6197-01 COSM3693331 c.108G>T p.K36N Substitution - Missense 19:58558274-58558274 - PD6409a COSM5796810 c.347+10C>G p.? Unknown 19:58556677-58556677 - Pa08C COSM84564 c.472C>T p.R158W Substitution - Missense 19:58556169-58556169 - TCGA-AA-3514-01 COSM291502 c.186G>C p.L62L Substitution - coding silent 19:58557081-58557081 - ESO-582 COSM1269624 c.478T>C p.F160L Substitution - Missense 19:58556163-58556163 - TCGA-A6-2686-01 COSM5085184 c.460C>T p.Q154* Substitution - Nonsense 19:58556181-58556181 - LP6005690-DNA_D02 COSM5037155 c.359A>C p.K120T Substitution - Missense 19:58556368-58556368 - pfg007T COSM1641265 c.194G>C p.C65S Substitution - Missense 19:58557073-58557073 - TCGA-BL-A3JM-01 COSM1305244 c.105G>A p.Q35Q Substitution - coding silent 19:58558277-58558277 - LUAD-CHTN-MAD06-00490 COSM357988 c.104A>T p.Q35L Substitution - Missense 19:58558278-58558278 - Pat_41_B COSM3404733 c.411+1G>A p.? Unknown 19:58556315-58556315 - LOVO COSM2726891 c.497G>A p.R166H Substitution - Missense 19:58556144-58556144 - TCGA-25-1324-01 COSM78739 c.328G>A p.V110I Substitution - Missense 19:58556706-58556706 - DLD1 COSM1681477 c.512G>A p.G171D Substitution - Missense 19:58556129-58556129 - TCGA-CM-4748-01 COSM5156992 c.347+5G>A p.? Unknown 19:58556682-58556682 - PD6732b COSM5768952 c.444G>T p.E148D Substitution - Missense 19:58556197-58556197 - TCGA-DU-6402-01 COSM3971328 c.308A>G p.N103S Substitution - Missense 19:58556726-58556726 - G18 COSM1191852 c.46T>G p.S16A Substitution - Missense 19:58558336-58558336 - TCGA-AA-3492-01 COSM1397354 c.50C>T p.A17V Substitution - Missense 19:58558332-58558332 - 16461 COSM5614735 c.509G>T p.G170V Substitution - Missense 19:58556132-58556132 - YUMOBER COSM5391023 c.231_232delGT p.F78fs*3 Deletion - Frameshift 19:58556903-58556904 - TCGA-28-5204-01 COSM3404733 c.411+1G>A p.? Unknown 19:58556315-58556315 - OSCC-GB_01280111 COSM5954194 c.411+3G>T p.? Unknown 19:58556313-58556313 - ESCC-185T COSM3938353 c.380C>A p.S127Y Substitution - Missense 19:58556347-58556347 - TCGA-D3-A1Q1-06 COSM2726890 c.505C>T p.R169W Substitution - Missense 19:58556136-58556136 - TCGA-CM-5861-01 COSM5158064 c.412-7G>A p.? Unknown 19:58556236-58556236 - TCGA-A6-2686-01 COSM5085183 c.470G>A p.R157Q Substitution - Missense 19:58556171-58556171 - BRC51 COSM5028646 c.145delA p.I49fs*45 Deletion - Frameshift 19:58557122-58557122 -

Mutation - CGAP UNIGENE CYTOBAND OMIM SNP Hs.406068 19q13.43 603173

Mutation - IntOGen Mutated from(ref) Mutated to(alt) Consequence Type AA Mutation CDS Mutation Chr Pos Cancer A G Missense p.F160L c.478T>C 19 59067530 ESCA C A IntronicSNV . c.243+11G>T 19 59068248 NSCLC C - Frameshift p.G83Afs*11 c.248delG 19 59068153 LUSC C G Missense p.C65S c.194G>C 19 59068440 STAD C G Synonymous p.L62L c.186G>C 19 59068448 COREAD C T Missense p.R158W c.472C>T 19 59067536 PAAD C T Missense p.V110I c.328G>A 19 59068073 OV C T SpliceDonorSNV . c.411+1G>A 19 59067682 GBM C T Synonymous p.K75K c.225G>A 19 59068277 HNSC C T Synonymous p.Q35Q c.105G>A 19 59069644 BLCA G A Missense p.R169W c.505C>T 19 59067503 CM T A CdsStopSNV . c.549A>T 19 59067459 LUAD T C Missense p.N103S c.308A>G 19 59068093 LGG T - Frameshift p.I49Sfs*45 c.145delA 19 59068489 BRCA