Disease associated variation - ClinVar Allele ID Type Name RS#dbSNP Phenotype IDs Chromosome Start Stop Reference Alternate 23169 single nucleotide variant NM_138712.3(PPARG):c.254C>A (p.Pro85Gln) 1800571 MedGen:C0028756,SNOMED CT:C0028756 3 12422848 12422848 C A 23169 single nucleotide variant NM_138712.3(PPARG):c.254C>A (p.Pro85Gln) 1800571 MedGen:C0028756,SNOMED CT:C0028756 3 12381349 12381349 C A 23170 single nucleotide variant NM_138712.3(PPARG):c.34C>G (p.Pro12Ala) 1805192 - 3 12421238 12421238 C G 23170 single nucleotide variant NM_138712.3(PPARG):c.34C>G (p.Pro12Ala) 1805192 - 3 12379739 12379739 C G 23171 deletion NM_138712.3(PPARG):c.472delA (p.Ser158Valfs) 587776687 MedGen:C0699790,OMIM:114500,SNOMED CT:C0699790 3 12434188 12434188 A - 23171 deletion NM_138712.3(PPARG):c.472delA (p.Ser158Valfs) 587776687 MedGen:C0699790,OMIM:114500,SNOMED CT:C0699790 3 12392689 12392689 A - 23172 single nucleotide variant NM_138712.3(PPARG):c.857A>C (p.Gln286Pro) 121909242 MedGen:C0699790,OMIM:114500,SNOMED CT:C0699790 3 12458324 12458324 A C 23172 single nucleotide variant NM_138712.3(PPARG):c.857A>C (p.Gln286Pro) 121909242 MedGen:C0699790,OMIM:114500,SNOMED CT:C0699790 3 12416825 12416825 A C 23173 single nucleotide variant NM_138712.3(PPARG):c.955A>T (p.Lys319Ter) 121909243 MedGen:C0699790,OMIM:114500,SNOMED CT:C0699790 3 12458422 12458422 A T 23173 single nucleotide variant NM_138712.3(PPARG):c.955A>T (p.Lys319Ter) 121909243 MedGen:C0699790,OMIM:114500,SNOMED CT:C0699790 3 12416923 12416923 A T 23174 single nucleotide variant NM_138712.3(PPARG):c.863G>A (p.Arg288His) 28936407 MedGen:C0699790,OMIM:114500,SNOMED CT:C0699790 3 12458330 12458330 G A 23174 single nucleotide variant NM_138712.3(PPARG):c.863G>A (p.Arg288His) 28936407 MedGen:C0699790,OMIM:114500,SNOMED CT:C0699790 3 12416831 12416831 G A 23175 single nucleotide variant NM_015869.4(PPARG):c.1484C>T (p.Pro495Leu) 121909244 MedGen:CN069127;MedGen:C0271694,Orphanet:ORPHA98306,SNOMED CT:C0271694;MedGen:C1720861,OMIM:604367,Orphanet:ORPHA79083;MedGen:C0028754,OMIM:601665,Orphanet:ORPHA71529,SNOMED CT:C0028754 3 12475610 12475610 C T 23175 single nucleotide variant NM_015869.4(PPARG):c.1484C>T (p.Pro495Leu) 121909244 MedGen:CN069127;MedGen:C0271694,Orphanet:ORPHA98306,SNOMED CT:C0271694;MedGen:C1720861,OMIM:604367,Orphanet:ORPHA79083;MedGen:C0028754,OMIM:601665,Orphanet:ORPHA71529,SNOMED CT:C0028754 3 12434111 12434111 C T 23176 single nucleotide variant NM_138712.3(PPARG):c.868G>A (p.Val290Met) 72551362 MedGen:C1720861,OMIM:604367,Orphanet:ORPHA79083 3 12458335 12458335 G A 23176 single nucleotide variant NM_138712.3(PPARG):c.868G>A (p.Val290Met) 72551362 MedGen:C1720861,OMIM:604367,Orphanet:ORPHA79083 3 12416836 12416836 G A 23177 single nucleotide variant PPARG, 161C-T -1 - na -1 -1 na na 23178 single nucleotide variant NM_015869.4(PPARG):c.1431C>T (p.His477=) 3856806 MedGen:CN069127;MedGen:C0271694,Orphanet:ORPHA98306,SNOMED CT:C0271694;MedGen:C2750850,OMIM:137800;MedGen:C0028754,OMIM:601665,Orphanet:ORPHA71529,SNOMED CT:C0028754;MedGen:CN169374 3 12475557 12475557 C T 23178 single nucleotide variant NM_015869.4(PPARG):c.1431C>T (p.His477=) 3856806 MedGen:CN069127;MedGen:C0271694,Orphanet:ORPHA98306,SNOMED CT:C0271694;MedGen:C2750850,OMIM:137800;MedGen:C0028754,OMIM:601665,Orphanet:ORPHA71529,SNOMED CT:C0028754;MedGen:CN169374 3 12434058 12434058 C T 23179 indel PPARG, 3-BP DEL/1-BP INS, NT553 -1 MedGen:CN069127;MedGen:C4017629 na -1 -1 na na 23180 single nucleotide variant NM_138712.3(PPARG):c.1080T>A (p.Phe360Leu) 72551363 MedGen:C1720861,OMIM:604367,Orphanet:ORPHA79083 3 12458547 12458547 T A 23180 single nucleotide variant NM_138712.3(PPARG):c.1080T>A (p.Phe360Leu) 72551363 MedGen:C1720861,OMIM:604367,Orphanet:ORPHA79083 3 12417048 12417048 T A 23181 single nucleotide variant NM_138712.3(PPARG):c.1189C>T (p.Arg397Cys) 72551364 MedGen:C1720861,OMIM:604367,Orphanet:ORPHA79083 3 12475399 12475399 C T 23181 single nucleotide variant NM_138712.3(PPARG):c.1189C>T (p.Arg397Cys) 72551364 MedGen:C1720861,OMIM:604367,Orphanet:ORPHA79083 3 12433900 12433900 C T 23182 single nucleotide variant NM_138712.3(PPARG):c.484T>A (p.Cys162Ser) 121909245 MedGen:C1720861,OMIM:604367,Orphanet:ORPHA79083 3 12434200 12434200 T A 23182 single nucleotide variant NM_138712.3(PPARG):c.484T>A (p.Cys162Ser) 121909245 MedGen:C1720861,OMIM:604367,Orphanet:ORPHA79083 3 12392701 12392701 T A 23183 single nucleotide variant NM_138712.3(PPARG):c.496C>T (p.Arg166Trp) 121909246 MedGen:C1720861,OMIM:604367,Orphanet:ORPHA79083 3 12434212 12434212 C T 23183 single nucleotide variant NM_138712.3(PPARG):c.496C>T (p.Arg166Trp) 121909246 MedGen:C1720861,OMIM:604367,Orphanet:ORPHA79083 3 12392713 12392713 C T 135464 single nucleotide variant NM_015869.4(PPARG):c.1348A>C (p.Lys450Gln) 587780424 MedGen:CN221809 3 12475474 12475474 A C 135464 single nucleotide variant NM_015869.4(PPARG):c.1348A>C (p.Lys450Gln) 587780424 MedGen:CN221809 3 12433975 12433975 A C 135465 single nucleotide variant NM_015869.4(PPARG):c.34C>G (p.Pro12Ala) 1801282 MedGen:CN069127;MedGen:C0271694,Orphanet:ORPHA98306,SNOMED CT:C0271694;MedGen:C0028754,OMIM:601665,Orphanet:ORPHA71529,SNOMED CT:C0028754;MedGen:CN169374 3 12351626 12351626 C G 135465 single nucleotide variant NM_015869.4(PPARG):c.34C>G (p.Pro12Ala) 1801282 MedGen:CN069127;MedGen:C0271694,Orphanet:ORPHA98306,SNOMED CT:C0271694;MedGen:C0028754,OMIM:601665,Orphanet:ORPHA71529,SNOMED CT:C0028754;MedGen:CN169374 3 12393125 12393125 C G 207033 single nucleotide variant NM_015869.4(PPARG):c.669G>A (p.Ala223=) 751812338 MedGen:CN169374 3 12405931 12405931 G A 207033 single nucleotide variant NM_015869.4(PPARG):c.669G>A (p.Ala223=) 751812338 MedGen:CN169374 3 12447430 12447430 G A 288404 single nucleotide variant NM_015869.4(PPARG):c.240C>T (p.Asp80=) 112174008 MedGen:CN069127;MedGen:C0271694,Orphanet:ORPHA98306,SNOMED CT:C0271694;MedGen:C0028754,OMIM:601665,Orphanet:ORPHA71529,SNOMED CT:C0028754 3 12421360 12421360 C T 288404 single nucleotide variant NM_015869.4(PPARG):c.240C>T (p.Asp80=) 112174008 MedGen:CN069127;MedGen:C0271694,Orphanet:ORPHA98306,SNOMED CT:C0271694;MedGen:C0028754,OMIM:601665,Orphanet:ORPHA71529,SNOMED CT:C0028754 3 12379861 12379861 C T 288413 single nucleotide variant NM_015869.4(PPARG):c.288C>T (p.Asp96=) 753817211 MedGen:CN069127;MedGen:C0271694,Orphanet:ORPHA98306,SNOMED CT:C0271694;MedGen:C0028754,OMIM:601665,Orphanet:ORPHA71529,SNOMED CT:C0028754 3 12379909 12379909 C T 288413 single nucleotide variant NM_015869.4(PPARG):c.288C>T (p.Asp96=) 753817211 MedGen:CN069127;MedGen:C0271694,Orphanet:ORPHA98306,SNOMED CT:C0271694;MedGen:C0028754,OMIM:601665,Orphanet:ORPHA71529,SNOMED CT:C0028754 3 12421408 12421408 C T 288431 single nucleotide variant NM_015869.4(PPARG):c.507G>A (p.Leu169=) 41415646 MedGen:CN069127;MedGen:C0271694,Orphanet:ORPHA98306,SNOMED CT:C0271694;MedGen:C0028754,OMIM:601665,Orphanet:ORPHA71529,SNOMED CT:C0028754 3 12392640 12392640 G A 288431 single nucleotide variant NM_015869.4(PPARG):c.507G>A (p.Leu169=) 41415646 MedGen:CN069127;MedGen:C0271694,Orphanet:ORPHA98306,SNOMED CT:C0271694;MedGen:C0028754,OMIM:601665,Orphanet:ORPHA71529,SNOMED CT:C0028754 3 12434139 12434139 G A 288432 single nucleotide variant NM_015869.4(PPARG):c.1206C>A (p.Phe402Leu) 886057902 MedGen:CN069127;MedGen:C0271694,Orphanet:ORPHA98306,SNOMED CT:C0271694;MedGen:C0028754,OMIM:601665,Orphanet:ORPHA71529,SNOMED CT:C0028754 3 12417090 12417090 C A 288432 single nucleotide variant NM_015869.4(PPARG):c.1206C>A (p.Phe402Leu) 886057902 MedGen:CN069127;MedGen:C0271694,Orphanet:ORPHA98306,SNOMED CT:C0271694;MedGen:C0028754,OMIM:601665,Orphanet:ORPHA71529,SNOMED CT:C0028754 3 12458589 12458589 C A 289177 single nucleotide variant NM_015869.4(PPARG):c.481-3C>T 370830238 MedGen:CN069127;MedGen:C0271694,Orphanet:ORPHA98306,SNOMED CT:C0271694;MedGen:C0028754,OMIM:601665,Orphanet:ORPHA71529,SNOMED CT:C0028754 3 12392611 12392611 C T 289177 single nucleotide variant NM_015869.4(PPARG):c.481-3C>T 370830238 MedGen:CN069127;MedGen:C0271694,Orphanet:ORPHA98306,SNOMED CT:C0271694;MedGen:C0028754,OMIM:601665,Orphanet:ORPHA71529,SNOMED CT:C0028754 3 12434110 12434110 C T 292190 single nucleotide variant NM_015869.4(PPARG):c.-22C>T 200479885 MedGen:CN069127;MedGen:C0271694,Orphanet:ORPHA98306,SNOMED CT:C0271694;MedGen:C0028754,OMIM:601665,Orphanet:ORPHA71529,SNOMED CT:C0028754 3 12351571 12351571 C T 292190 single nucleotide variant NM_015869.4(PPARG):c.-22C>T 200479885 MedGen:CN069127;MedGen:C0271694,Orphanet:ORPHA98306,SNOMED CT:C0271694;MedGen:C0028754,OMIM:601665,Orphanet:ORPHA71529,SNOMED CT:C0028754 3 12393070 12393070 C T 292296 single nucleotide variant NM_015869.4(PPARG):c.438T>C (p.Ala146=) 147975759 MedGen:CN069127;MedGen:C0271694,Orphanet:ORPHA98306,SNOMED CT:C0271694;MedGen:C0028754,OMIM:601665,Orphanet:ORPHA71529,SNOMED CT:C0028754 3 12422948 12422948 T C 292296 single nucleotide variant NM_015869.4(PPARG):c.438T>C (p.Ala146=) 147975759 MedGen:CN069127;MedGen:C0271694,Orphanet:ORPHA98306,SNOMED CT:C0271694;MedGen:C0028754,OMIM:601665,Orphanet:ORPHA71529,SNOMED CT:C0028754 3 12381449 12381449 T C 292303 single nucleotide variant NM_015869.4(PPARG):c.891C>G (p.Pro297=) 13306747 MedGen:CN069127;MedGen:C0271694,Orphanet:ORPHA98306,SNOMED CT:C0271694;MedGen:C0028754,OMIM:601665,Orphanet:ORPHA71529,SNOMED CT:C0028754 3 12416775 12416775 C G 292303 single nucleotide variant NM_015869.4(PPARG):c.891C>G (p.Pro297=) 13306747 MedGen:CN069127;MedGen:C0271694,Orphanet:ORPHA98306,SNOMED CT:C0271694;MedGen:C0028754,OMIM:601665,Orphanet:ORPHA71529,SNOMED CT:C0028754 3 12458274 12458274 C G 292305 single nucleotide variant NM_015869.4(PPARG):c.1371A>G (p.Ser457=) 41516544 MedGen:CN069127;MedGen:C0271694,Orphanet:ORPHA98306,SNOMED CT:C0271694;MedGen:C0028754,OMIM:601665,Orphanet:ORPHA71529,SNOMED CT:C0028754 3 12433998 12433998 A G 292305 single nucleotide variant NM_015869.4(PPARG):c.1371A>G (p.Ser457=) 41516544 MedGen:CN069127;MedGen:C0271694,Orphanet:ORPHA98306,SNOMED CT:C0271694;MedGen:C0028754,OMIM:601665,Orphanet:ORPHA71529,SNOMED CT:C0028754 3 12475497 12475497 A G 292306 single nucleotide variant NM_015869.4(PPARG):c.1452C>T (p.Ile484=) 149367249 MedGen:CN069127;MedGen:C0271694,Orphanet:ORPHA98306,SNOMED CT:C0271694;MedGen:C0028754,OMIM:601665,Orphanet:ORPHA71529,SNOMED CT:C0028754 3 12434079 12434079 C T 292306 single nucleotide variant NM_015869.4(PPARG):c.1452C>T (p.Ile484=) 149367249 MedGen:CN069127;MedGen:C0271694,Orphanet:ORPHA98306,SNOMED CT:C0271694;MedGen:C0028754,OMIM:601665,Orphanet:ORPHA71529,SNOMED CT:C0028754 3 12475578 12475578 C T 292310 single nucleotide variant NM_015869.4(PPARG):c.1509C>T (p.Asp503=) 886057903 MedGen:CN069127;MedGen:C0271694,Orphanet:ORPHA98306,SNOMED CT:C0271694;MedGen:C0028754,OMIM:601665,Orphanet:ORPHA71529,SNOMED CT:C0028754 3 12434136 12434136 C T 292310 single nucleotide variant NM_015869.4(PPARG):c.1509C>T (p.Asp503=) 886057903 MedGen:CN069127;MedGen:C0271694,Orphanet:ORPHA98306,SNOMED CT:C0271694;MedGen:C0028754,OMIM:601665,Orphanet:ORPHA71529,SNOMED CT:C0028754 3 12475635 12475635 C T

Disease associated variation - GWASdb Chr Pos SNP ID(dbSNP 142) Ref Alt Ori SNP ID P-value Drug Name Drug Anno GWAS Trait HPO ID DO ID AA Type Trait or Drug 3 12408278 rs2938397 A G rs2938397 8.30E-05 ROSUVASTATIN FLUOROBENZENES|PYRIMIDINES|SULFONAMIDES|1-ALKYL-2-ACETYLGLYCEROPHOSPHOCHOLINE ESTERASE Lipoprotein-associated phospholipase A2 activity change in response to statin therapy HPOID:0010979 DOID:3393|DOID:1936 T intron GWASdb_drug 3 12329783 rs17036160 C T rs17036160 0.00000787 Type 2 diabetes HPOID:0005978 DOID:9352 C intron GWASdb_trait 3 12330411 rs17036170 G A rs17036170 2.00E-08 Drug-induced liver injury HPOID:0001392 DOID:2044 G intron GWASdb_trait 3 12334416 rs2972164 T C rs2972164 0.00003 Coronary artery calcification HPOID:0001677 DOID:3393 C intron GWASdb_trait 3 12336507 rs11709077 G A rs11709077 5.10E-04 Multiple complex diseases HPOID:0000118 NA G intron GWASdb_trait 3 12336507 rs11709077 G A rs11709077 6.98E-04 Alzheimer's disease HPOID:0002511 DOID:10652 G intron GWASdb_trait 3 12336507 rs11709077 G A rs11709077 0.000000011 Type 2 diabetes (females) HPOID:0005978 DOID:9352 G intron GWASdb_trait 3 12336507 rs11709077 G A rs11709077 0.00000015 Type 2 diabetes (males) HPOID:0005978 DOID:9352 G intron GWASdb_trait 3 12338849 rs4684846 A G rs4684846 0.00037 Coronary artery calcification HPOID:0001677 DOID:3393 A intron GWASdb_trait 3 12342861 rs12631819 G T rs12631819 0.00000835 HDL cholesterol HPOID:0003107 DOID:14502|DOID:1461|DOID:3393 G intron GWASdb_trait 3 12343117 rs11128596 A C rs11128596 0.00027 Coronary artery calcification HPOID:0001677 DOID:3393 C intron GWASdb_trait 3 12351223 rs12485478 A G rs12485478 0.0000359 HDL cholesterol HPOID:0003107 DOID:14502|DOID:1461|DOID:3393 A intron GWASdb_trait 3 12356158 rs12496505 G A rs12496505 0.00029 Coronary artery calcification HPOID:0001677 DOID:3393 G intron GWASdb_trait 3 12358492 rs13433696 G A rs13433696 0.00029 Coronary artery calcification HPOID:0001677 DOID:3393 A intron GWASdb_trait 3 12363358 rs7646510 A G rs7646510 2.05E-08 LDL cholesterol HPOID:0010979 DOID:1936|DOID:3393 A intron GWASdb_trait 3 12368038 rs3892175 G A rs3892175 9.96E-04 Alzheimer's disease HPOID:0002511 DOID:10652 G intron GWASdb_trait 3 12371082 rs12496005 G C rs12496005 0.00021 Coronary artery calcification HPOID:0001677 DOID:3393 A intron GWASdb_trait 3 12384542 rs12490265 G A rs12490265 2.10E-05 Urinary metabolites HPOID:0000079 DOID:557 G intron GWASdb_trait 3 12384599 rs17036321 T C rs17036321 7.44E-08 LDL cholesterol HPOID:0010979 DOID:1936|DOID:3393 T intron GWASdb_trait 3 12385828 rs11128603 A G rs11128603 9.00E-08 Plasminogen activator inhibitor type 1 levels (PAI-1) HPOID:0005978|HPOID:0001677 DOID:9352|DOID:3393 A intron GWASdb_trait 3 12390484 rs17036328 T C rs17036328 3.46E-04 Multiple complex diseases HPOID:0000118 NA T intron GWASdb_trait 3 12390484 rs17036328 T C rs17036328 3.59E-12 Fasting insulin-related traits HPOID:0008283 DOID:9352 T intron GWASdb_trait 3 12392272 rs7649970 C T rs7649970 0.00000454 Type 2 diabetes HPOID:0005978 DOID:9352 C intron GWASdb_trait 3 12393125 rs1801282 C G rs1801282 2.00E-06 Type 2 diabetes HPOID:0005978 DOID:9352 C missense GWASdb_trait 3 12393125 rs1801282 C G rs1801282 2.00E-06 Type 2 diabetes HPOID:0005978 DOID:9352 C missense GWASdb_trait 3 12393125 rs1801282 C G rs1801282 2.00E-06 Type 2 diabetes HPOID:0005978 DOID:9352 C missense GWASdb_trait 3 12393125 rs1801282 C G rs1801282 2.31E-04 Alzheimer's disease HPOID:0002511 DOID:10652 C missense GWASdb_trait 3 12393125 rs1801282 C G rs1801282 2.00E-06 Coronary heart disease HPOID:0001677 DOID:3393 C missense GWASdb_trait 3 12393125 rs1801282 C G rs1801282 2.00E-06 Type 2 diabetes HPOID:0005978 DOID:9352 C missense GWASdb_trait 3 12393125 rs1801282 C G rs1801282 0.0000215 Type 2 diabetes HPOID:0005978 DOID:9352 C missense GWASdb_trait 3 12393125 rs1801282 C G rs1801282 2.00E-07 Fasting insulin-related traits (interaction with BMI) HPOID:0008283 DOID:9352 C missense GWASdb_trait 3 12393125 rs1801282 C G rs1801282 0.00033 Fasting insulin-related traits HPOID:0008283 DOID:9352 C missense GWASdb_trait 3 12393125 rs1801282 C G rs1801282 1.10E-12 Type 2 diabetes HPOID:0005978 DOID:9352 C missense GWASdb_trait 3 12393125 rs1801282 C G rs1801282 1.40E-07 Plasminogen activator inhibitor type 1 levels (PAI-1) HPOID:0005978|HPOID:0001677 DOID:9352|DOID:3393 C missense GWASdb_trait 3 12393125 rs1801282 C G rs1801282 1.70E-06 Type 2 diabetes HPOID:0005978 DOID:9352 C missense GWASdb_trait 3 12393125 rs1801282 C G rs1801282 6.00E-10 Type 2 diabetes HPOID:0005978 DOID:9352 C missense GWASdb_trait 3 12394840 rs1899951 C T rs1899951 0.00000037 Type 2 diabetes HPOID:0005978 DOID:9352 A intron GWASdb_trait 3 12408278 rs2938397 A G rs2938397 8.30E-05 Lipoprotein-associated phospholipase A2 activity change in response to statin therapy HPOID:0010979 DOID:3393|DOID:1936 T intron GWASdb_trait 3 12410290 rs73025249 G A rs73025249 0.0000217 Menopause (age at onset) HPOID:0100805 DOID:9970|DOID:9352|DOID:1287|DOID:11476|DOID:1612|DOID:10652 G intron GWASdb_trait 3 12421056 rs13306745 G T rs13306745 3.50E-17 HDL cholesterol HPOID:0003107 DOID:14502|DOID:1461|DOID:3393 G intron GWASdb_trait 3 12437237 rs4135268 C G rs4135268 9.20E-06 Memory performance HPOID:0002354 DOID:1561 C intron GWASdb_trait 3 12443844 rs4135275 A G rs4135275 1.35E-04 Alcohol dependence HPOID:0000707 DOID:0050741 A intron GWASdb_trait 3 12447268 rs73027210 G A rs73027210 0.0000217 Menopause (age at onset) HPOID:0100805 DOID:9970|DOID:9352|DOID:1287|DOID:11476|DOID:1612|DOID:10652 G intron GWASdb_trait 3 12454621 rs114451007 A T rs114451007 0.0000093 Menopause (age at onset) HPOID:0100805 DOID:9970|DOID:9352|DOID:1287|DOID:11476|DOID:1612|DOID:10652 A intron GWASdb_trait 3 12468627 rs17036700 G T rs17036700 2.44E-04 Multiple complex diseases HPOID:0000118 NA G intron GWASdb_trait 3 12470239 rs1797912 A C rs1797912 0.0000548 Type 2 diabetes HPOID:0005978 DOID:9352 C intron GWASdb_trait 3 12470663 rs4135361 G A rs4135361 5.22E-11 LDL cholesterol HPOID:0010979 DOID:1936|DOID:3393 G intron GWASdb_trait 3 12475088 rs7626560 C T rs7626560 2.40E-05 Urinary metabolites HPOID:0000079 DOID:557 T intron GWASdb_trait 3 12475162 rs7650895 A C rs7650895 2.40E-05 Urinary metabolites HPOID:0000079 DOID:557 C intron GWASdb_trait

Disease associated variation - OMIM Ensembl_gene_ID Approved Gene Symbol MIM Number ENSG00000132170.19 PPARG 601487