PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus PTPN12 TRIM47 22863883 biogrid exp GP P G P GP G GP GP G GP GP GP GP G GP GP G GP P GP GP GP GP GP G TRIM47 DNPEP 22863883 biogrid exp GP P G P GP G GP GP G GP GP GP GP G GP GP G GP P GP GP GP GP GP G PPP1R12A TRIM47 22863883 biogrid exp G G GP G GP GP G G G G G G GP GP G GP P G G GP G GP G TNS3 TRIM47 22863883 biogrid exp G P G P GP G GP GP G GP G GP GP G GP GP G GP P G GP GP GP GP G PDK1 TRIM47 26496610 biogrid,intact exp GP P G P GP GP GP G GP GP GP GP G GP GP G GP P GP GP GP GP GP TRIM47 TRIM8 22493164 biogrid,intact exp GP P G P GP G GP GP G GP GP GP GP G GP GP G GP P GP GP GP GP GP G GANAB TRIM47 22863883 biogrid exp GP P G P GP G G GP G GP GP GP GP G GP GP G GP P GP GP GP G GP G APP TRIM47 21832049 biogrid exp G P G P GP G G GP G G G G G G GP GP G GP P GP G GP G G G CUL1 TRIM47 22863883 biogrid exp GP G GP G GP GP G GP GP GP G G GP GP G GP P GP GP GP GP GP G TRIM47 TSG101 19542561 biogrid exp GP P G P GP G GP GP G GP GP GP GP G GP GP G GP P GP GP GP GP GP G ANKS1A TRIM47 22863883 biogrid exp GP P G P G G G GP G GP GP GP GP G GP G G GP P GP GP GP GP GP G TPP2 TRIM47 22863883 biogrid exp GP P G P GP G GP GP G GP GP GP GP G GP GP G GP P GP GP GP GP GP G UBE2U TRIM47 19690564 biogrid,intact exp P P P P P P P P P P P P P P P P P P TRIM47 NUDT5 22863883 biogrid exp G G G G G G G GP GP G G G G G G G G G G G G G TERF2 TRIM47 20811636 biogrid exp GP P G P GP G GP GP G GP GP GP GP G GP GP G GP P GP GP GP GP GP G TRIM47 TRIM5 23023127 pred GP P P P G GP GP GP GP GP GP G GP P G GP P GP GP GP GP GP G BRCA1 TRIM47 23023127 pred P P P P P P P P P P GP P P P P P P P P TBL1X TRIM47 21836163 pred GP P G P GP G GP GP G GP GP GP GP G GP GP G GP P GP GP GP GP GP G TRIM47 SAGE1 21836163 pred P TRIM47 RNF19A 23023127 pred GP P G P GP G GP GP G GP GP GP GP G GP GP G GP P GP GP GP GP GP G TRIM47 RNF114 23023127 pred GP P G P GP G GP GP G GP GP GP GP G GP GP G GP P GP GP GP GP GP G TRIM47 TRIM56 23023127 pred GP P G P GP G GP GP G GP G GP GP G GP GP G GP P GP G GP GP GP G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q96LD4 P05067-7 pull down 21832049 direct interaction X 2 Q96LD4 biochemical 22863883 colocalization X 2 Q96LD4 Q05209-2 biochemical 22863883 colocalization X 2 Q96LD4 Q68CZ2 biochemical 22863883 colocalization X 2 Q96LD4 Q9UKK9 biochemical 22863883 colocalization X 2 Q96LD4 biochemical 22863883 colocalization X 2 Q96LD4 P29144 biochemical 22863883 colocalization X 2 Q96LD4 Q15554 affinity chromatography technology 20811636 physical association X 2 Q96LD4 Q99816 affinity chromatography technology 19542561 physical association X 2 Q96LD4 O15205 affinity chromatography technology 22797925 physical association X 2 Q96LD4 Q9BZR9 two hybrid 22493164 direct interaction X 2 Q96LD4 Q92625 biochemical 22863883 colocalization X 2 Q96LD4 Q14697-2 biochemical 22863883 colocalization X 2 Q96LD4 A0A090N7U0 biochemical 22863883 colocalization X 2 Q96LD4 two hybrid 19690564 direct interaction X 2 P0CG48 Q96LD4 affinity chromatography technology 21963094 physical association X 2 P0CG48 Q96LD4 affinity chromatography technology 21987572 physical association X 2 P0CG48 Q96LD4 affinity chromatography technology 21906983 physical association X 2 Q96LD4 Q5VVX9 two hybrid array 19690564 physical association X 2 Q96LD4 Q81RJ7 two hybrid pooling approach 20711500 physical association X 2 Q96LD4 Q8CZT3 two hybrid pooling approach 20711500 physical association X 2 Q96LD4 Q7CH90 two hybrid pooling approach 20711500 physical association X 2 Q96LD4 Q9BZR9 two hybrid array 22493164 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B APP TRIM47 MI:0096(pull down) 21832049 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_229548 prey bait TRIM47 TSG101 MI:0686(unspecified method) 19542561 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_192319 prey bait UBD TRIM47 MI:0004(affinity chromatography technology) 22797925 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_226520 bait prey TNS3 TRIM47 MI:0401(biochemical) 22863883 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_304383 prey bait PPP1R12A TRIM47 MI:0401(biochemical) 22863883 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_304483 bait prey PTPN12 TRIM47 MI:0401(biochemical) 22863883 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_302760 prey bait TRIM47 TRIM8 MI:0415(enzymatic study)|MI:0397(two hybrid array) 22493164 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_283969|UniProt_122602 bait|prey prey|bait CUL1 TRIM47 MI:0401(biochemical) 22863883 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_304481 bait prey TERF2 TRIM47 MI:0004(affinity chromatography technology) 20811636 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_141069 bait prey UBE2U TRIM47 MI:0397(two hybrid array)|MI:0018(two hybrid) 19690564 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_102671|BIOGRID_123682 bait|bait prey|prey TRIM47 NUDT5 MI:0401(biochemical) 22863883 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_304482 prey bait UBC TRIM47 MI:0415(enzymatic study)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 21906983,21963094,21987572 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid) BIOGRID_163939|BIOGRID_181633|BIOGRID_265196 bait|bait|bait prey|prey|prey TRIM47 DNPEP MI:0401(biochemical) 22863883 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_299374 bait prey GANAB TRIM47 MI:0401(biochemical) 22863883 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_299830 prey bait TPP2 TRIM47 MI:0401(biochemical) 22863883 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_304484 bait prey ANKS1A TRIM47 MI:0401(biochemical) 22863883 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_298428 prey bait

PPI - HINT Gene A Gene B PMID Method Quality PPP1R12A TRIM47 22863883 0401 HT TPP2 TRIM47 22863883 0401 HT PTPN12 TRIM47 22863883 0401 HT CUL1 TRIM47 22863883 0401 HT PDK1 TRIM47 26496610,26496610 0007,0004 HT TNS3 TRIM47 22863883 0401 HT ANKS1A TRIM47 22863883 0401 HT TRIM47 NUDT5 22863883 0401 HT TRIM47 DNPEP 22863883 0401 HT TRIM47 HEL-S-164NA 22863883 0401 HT PPP1R12A TRIM47 22863883 0401 HT TPP2 TRIM47 22863883 0401 HT PTPN12 TRIM47 22863883 0401 HT CUL1 TRIM47 22863883 0401 HT PDK1 TRIM47 26496610,26496610 0007,0004 HT TNS3 TRIM47 22863883 0401 HT ANKS1A TRIM47 22863883 0401 HT TRIM47 NUDT5 22863883 0401 HT TRIM47 DNPEP 22863883 0401 HT TRIM47 HEL-S-164NA 22863883 0401 HT PPP1R12A TRIM47 22863883 0401 LC TPP2 TRIM47 22863883 0401 LC PTPN12 TRIM47 22863883 0401 LC CUL1 TRIM47 22863883 0401 LC UBE2U TRIM47 19690564,19690564 0397,0018 HT TNS3 TRIM47 22863883 0401 LC ANKS1A TRIM47 22863883 0401 LC TRIM47 TRIM8 22493164,22493164 0018,0397 HT TRIM47 NUDT5 22863883 0401 LC TRIM47 DNPEP 22863883 0401 LC TRIM47 HEL-S-164NA 22863883 0401 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q96LD4 O14974 TRIM47 PPP1R12A 0.081 22863883 Q96LD4 Q7CH90 TRIM47 DING 0.126 20711500 Q96LD4 Q81RJ7 TRIM47 Q81RJ7 0.126 20711500 Q9BZR9 Q96LD4 TRIM8 TRIM47 0.286 22493164 Q96LD4 Q13867 TRIM47 BLMH 0.236 unassigned1304 Q99KJ8 Q96LD4 DCTN2 TRIM47 0.236 26496610 Q96LD4 Q15118 TRIM47 PDK1 0.236 26496610 Q96LD4 A2AGT5 TRIM47 CKAP5 0.236 26496610 Q96LD4 P05067 TRIM47 APP 0.183 21832049 Q96LD4 Q05209 TRIM47 PTPN12 0.081 22863883 Q96LD4 Q14697 TRIM47 GANAB 0.081 22863883 Q96LD4 Q5VVX9 TRIM47 UBE2U 0.376 19690564 Q96LD4 Q68CZ2 TRIM47 TNS3 0.081 22863883 Q96LD4 Q8CZT3 TRIM47 CITT3 0.126 20711500 Q96LD4 Q92625 TRIM47 ANKS1A 0.081 22863883 Q99816 Q96LD4 TSG101 TRIM47 0.21 19542561 Q96LD4 P29144 TRIM47 TPP2 0.081 22863883 Q9UKK9 Q96LD4 NUDT5 TRIM47 0.081 22863883 Q96LD4 Q13616 TRIM47 CUL1 0.081 22863883 Q96LD4 Q15554 TRIM47 TERF2 0.126 20811636

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 UBD TRIM47 MI:0045 experimental interaction detection MI:0461 interaction database APP TRIM47 MI:0045 experimental interaction detection MI:0461 interaction database UBC TRIM47 MI:0045 experimental interaction detection MI:0461 interaction database DCTN2 TRIM47 MI:0362 inference MI:0461 interaction database CKAP5 TRIM47 MI:0362 inference MI:0461 interaction database PDK1 TRIM47 MI:0045 experimental interaction detection MI:0461 interaction database TERF2 TRIM47 MI:0045 experimental interaction detection MI:0461 interaction database UBE2U TRIM47 MI:0045 experimental interaction detection MI:0461 interaction database TRIM47 TSG101 MI:0045 experimental interaction detection MI:0461 interaction database TRIM47 TRIM8 MI:0045 experimental interaction detection MI:0461 interaction database