PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus WDR74 PUS7 22939629 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G GP G G G G G WDR74 HDAC11 23752268 biogrid,intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G WDR74 USP7 22939629 biogrid exp G G G G G G G GP G G G G G G G G G G G G G G G GP G G G G G GNL2 WDR74 26344197 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G GP G G G G G WDR74 CARD8 26186194 biogrid exp G G G G G G G GP G G G G G G G G G G G G G G G GP G G G G G NOP56 WDR74 26496610 biogrid,intact exp WDR74 VAT1 22939629 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G NUDT3 WDR74 21900206 biogrid,mint,intact exp G G G G G G G G G G G G G G G G GP G C17orf85 WDR74 26496610 biogrid,intact exp G G G G G G G GP G G G G G G G G G G G G G G G GP G G G G G WDR74 RCHY1 25416956 biogrid,intact exp G G G G G G G GP G G G G G G G G G G G G G G G G G G G G G WDR74 DDX47 26344197 biogrid exp G G G G G G G GP G G G G G G G G G G G G G G G GP G G G G G WDR74 CCNJL 26186194 biogrid exp G G G G G G GP G G G G G G G G G G G G G G G G G G G THOC5 WDR74 26496610 biogrid,intact exp G G G G G G G G G G G G G G G G G G G G G G G GP G G G G G NSUN2 WDR74 22939629 biogrid exp G G G G G G G GP G G G G G G G G G G G G G G G GP G G G G G RGS2 WDR74 16169070,21900206 hprd,biogrid,i2d,mint,intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PKN2 WDR74 26496610 biogrid,intact exp G G G G G G G GP G G G G G G G G G G G G G G G GP G G G G G WDR74 ZC3H15 26344197 biogrid exp G G G G G G G GP G G G G G G G G G G G G G G G GP G G G G G PDGFRA WDR74 26496610 biogrid,intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G SSB WDR74 26344197 biogrid exp G G G G G G G GP G G G G G G G G G G G G G G G GP G G G G G RRS1 WDR74 26344197 biogrid exp G G G G G G G GP G G G G G G G G G G G G G G G GP G G G G G WDR74 DHX37 26344197 biogrid exp G G G G G G G P G G G G G G G G G G G G G G GP G G G G G WBSCR22 WDR74 22939629 biogrid exp G G G G G G G GP G G G G G G G G G G G G G G G G G G G G G PPIP5K2 WDR74 22939629 biogrid exp G G G G G G G GP G G G G G G G G G G G G G G G P G G G G G DDX39B WDR74 22939629 biogrid exp P P XPO1 WDR74 26673895 biogrid exp G G G G G G G GP G G G G G G G G G G G G G G G GP G G G G G UBE3C WDR74 22939629 biogrid exp G G G G G G G GP G G G G G G G G G G G G G G G GP G G G G G WDR74 IBTK 26496610 biogrid,intact exp G G G G G G G G G G G G G G G G G G G G G G G GP G G G G G IFI16 WDR74 25693804 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G YWHAE WDR74 ortho G G G G G G G GP G G G G G G G G G G G G G G G GP G G G G G WDR74 DDX24 16082366 pred G G G G G G G GP G G G G G G G G G G G G G G G GP G G G G G WDR74 NIFK 16082366 pred G G G G G G G G G G G G G G G G G G G G G G G GP G G G G G LIG4 WDR74 16082366 pred G G G G G G G GP G G G G G G G G G G G GP G G G G NOP2 WDR74 16082366 pred G G G G G G G GP G G G G G G G G G G G G G G G G G G G G G BOP1 WDR74 16082366 pred G G G G G G G G G G G G G G G G G G G G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q6RFH5 O15205 affinity chromatography technology 22797925 physical association X 2 Q6RFH5 Q15386 biochemical 22939629 colocalization X 2 Q6RFH5 Q96PZ0 biochemical 22939629 colocalization X 2 Q6RFH5 Q08J23 biochemical 22939629 colocalization X 2 Q6RFH5 Q96PM5-2 two hybrid 25416956 direct interaction X 2 A0A024RCM3 Q6RFH5 biochemical 22939629 colocalization X 2 Q99536 Q6RFH5 biochemical 22939629 colocalization X 2 P0CG48 Q6RFH5 affinity chromatography technology 22505724 physical association X 2 P0CG48 Q6RFH5 affinity chromatography technology 21963094 physical association X 2 P0CG48 Q6RFH5 affinity chromatography technology 24816145 physical association X 2 P0CG48 Q6RFH5 affinity chromatography technology 21987572 physical association X 2 P0CG48 Q6RFH5 affinity chromatography technology 20972266 physical association X 2 P0CG48 Q6RFH5 affinity chromatography technology 21890473 physical association X 2 P0CG48 Q6RFH5 affinity chromatography technology 21906983 physical association X 2 O43314-2 Q6RFH5 biochemical 22939629 colocalization X 2 A0A024R939 Q6RFH5 two hybrid 16169070 direct interaction X 2 A0A024R939 Q6RFH5 two hybrid 21900206 direct interaction X 2 Q6RFH5 Q93009 biochemical 22939629 colocalization X 2 Q6RFH5 biochemical 22939629 colocalization X 2 Q6RFH5 Q96DB2-2 affinity chromatography technology 23752268 physical association X 2 O95989 Q6RFH5 two hybrid 21900206 direct interaction X 2 A0A024R939 Q6RFH5 two hybrid 16169070 - X 2 A0A024R939 Q6RFH5 two hybrid 16169070 - X 2 Q6RFH5 anti tag coimmunoprecipitation 23752268 association C 124 A0A024R939 Q6RFH5 two hybrid pooling approach 16169070 physical association X 2 A0A024R939 Q6RFH5 two hybrid 21900206 physical association X 2 O95989 Q6RFH5 two hybrid 21900206 physical association X 2 Q96PM5 Q6RFH5 two hybrid prey pooling approach 25416956 physical association X 2 Q96PM5 Q6RFH5 two hybrid array 25416956 physical association X 2 Q96PM5 Q6RFH5 validated two hybrid 25416956 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B WDR74 PUS7 MI:0401(biochemical) 22939629 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_241925 prey bait WDR74 HDAC11 MI:0004(affinity chromatography technology)|MI:0007(anti tag coimmunoprecipitation) 23752268 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0914(association) (biogrid)|(intact) BIOGRID_280869|UniProt_131422 prey|prey bait|bait UBD WDR74 MI:0004(affinity chromatography technology) 22797925 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_226756 bait prey WDR74 USP7 MI:0401(biochemical) 22939629 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_238696 prey bait WDR74 VAT1 MI:0401(biochemical) 22939629 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_243712 prey bait DDX39B WDR74 MI:0401(biochemical) 22939629 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_237466 bait prey NSUN2 WDR74 MI:0401(biochemical) 22939629 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_243428 bait prey RGS2 WDR74 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0007(anti tag coimmunoprecipitation)|MI:0018(two hybrid)|MI:0492(in vitro)|MI:0018(two hybrid) 16169070,21900206 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|-|MI:0915(physical association) (biogrid)|MI:0471(mint)|(intact)|(intact)|(intact)|(biogrid)|MI:0468(hprd)|MI:0471(mint) BIOGRID_157941|MINT_33896|UniProt_159724|UniProt_180322|UniProt_156488|BIOGRID_93914|HPRD_28764|MINT_62838 bait|bait|bait|bait|bait|bait|-|bait prey|prey|prey|prey|prey|prey|-|prey NUDT3 WDR74 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 21900206 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(intact)|(intact) BIOGRID_156780|UniProt_179981|UniProt_159383 bait|bait|bait prey|prey|prey UBE3C WDR74 MI:0401(biochemical) 22939629 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_238783 bait prey UBC WDR74 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0415(enzymatic study)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 20972266,21890473,21906983,21963094,21987572,22505724 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid) BIOGRID_164289|BIOGRID_173600|BIOGRID_163983|BIOGRID_224454|BIOGRID_265102|BIOGRID_181487 bait|bait|bait|bait|bait|bait prey|prey|prey|prey|prey|prey PPIP5K2 WDR74 MI:0401(biochemical) 22939629 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_242219 bait prey WBSCR22 WDR74 MI:0401(biochemical) 22939629 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_241996 bait prey

PPI - HINT Gene A Gene B PMID Method Quality NOP56 WDR74 26496610,26496610 0007,0004 HT PPIP5K2 WDR74 22939629 0401 HT WBSCR22 WDR74 22939629 0401 HT SSB WDR74 26344197 0401 HT PDGFRA WDR74 26496610,26496610 0007,0004 HT NSUN2 WDR74 22939629 0401 HT THOC5 WDR74 26496610,26496610 0007,0004 HT GNL2 WDR74 26344197 0401 HT DDX39B WDR74 22939629 0401 HT RRS1 WDR74 26344197 0401 HT UBE3C WDR74 22939629 0401 HT PKN2 WDR74 26496610,26496610 0007,0004 HT NCBP3 WDR74 26496610,26496610 0007,0004 HT WDR74 CCNJL 26186194 0004 HT WDR74 DHX37 26344197 0401 HT WDR74 ZC3H15 26344197 0401 HT WDR74 USP7 22939629 0401 HT WDR74 PUS7 22939629 0401 HT WDR74 VAT1 22939629 0401 HT WDR74 DDX47 26344197 0401 HT WDR74 IBTK 26496610,26496610 0007,0004 HT WDR74 CARD8 26186194 0004 HT NOP56 WDR74 26496610,26496610 0007,0004 HT PPIP5K2 WDR74 22939629 0401 HT WBSCR22 WDR74 22939629 0401 HT SSB WDR74 26344197 0401 HT PDGFRA WDR74 26496610,26496610 0007,0004 HT NSUN2 WDR74 22939629 0401 HT THOC5 WDR74 26496610,26496610 0007,0004 HT GNL2 WDR74 26344197 0401 HT DDX39B WDR74 22939629 0401 HT RRS1 WDR74 26344197 0401 HT UBE3C WDR74 22939629 0401 HT PKN2 WDR74 26496610,26496610 0007,0004 HT NCBP3 WDR74 26496610,26496610 0007,0004 HT WDR74 CCNJL 26186194 0004 HT WDR74 DHX37 26344197 0401 HT WDR74 ZC3H15 26344197 0401 HT WDR74 USP7 22939629 0401 HT WDR74 PUS7 22939629 0401 HT WDR74 VAT1 22939629 0401 HT WDR74 DDX47 26344197 0401 HT WDR74 IBTK 26496610,26496610 0007,0004 HT WDR74 CARD8 26186194 0004 HT PPIP5K2 WDR74 22939629 0401 LC WBSCR22 WDR74 22939629 0401 LC NUDT3 WDR74 21900206 0018 HT SSB WDR74 26344197 0401 LC RGS2 WDR74 16169070,21900206,16169070 0018,0018,0398 HT NSUN2 WDR74 22939629 0401 LC GNL2 WDR74 26344197 0401 LC DDX39B WDR74 22939629 0401 LC RRS1 WDR74 26344197 0401 LC UBE3C WDR74 22939629 0401 LC WDR74 DHX37 26344197 0401 LC WDR74 ZC3H15 26344197 0401 LC WDR74 USP7 22939629 0401 LC WDR74 RCHY1 25416956,25416956,25416956,25416956 1112,0397,0018,1356 HT WDR74 PUS7 22939629 0401 LC WDR74 VAT1 22939629 0401 LC WDR74 DDX47 26344197 0401 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q6RFH5 O14980 WDR74 XPO1 0.126 26673895 Q6RFH5 O43709 WDR74 WBSCR22 0.081 22939629 Q8IV13 Q6RFH5 CCNJL WDR74 0.126 26186194 Q9Y2G2 Q6RFH5 CARD8 WDR74 0.126 26186194 Q6RFH5 P41220 WDR74 RGS2 0.523 21900206,16169070 Q6RFH5 Q15050 WDR74 RRS1 0.081 26344197 Q8IY37 Q6RFH5 DHX37 WDR74 0.081 26344197 Q8WU90 Q6RFH5 ZC3H15 WDR74 0.081 26344197 Q9H0S4 Q6RFH5 DDX47 WDR74 0.081 26344197 Q6RFH5 Q6P5F9 WDR74 XPO1 0.126 26673895 Q6RFH5 P05455 WDR74 SSB 0.081 26344197 Q9P2D0 Q6RFH5 IBTK WDR74 0.236 26496610 Q8R050 Q6RFH5 GSPT1 WDR74 0.236 26496610 Q96PM5 Q6RFH5 RCHY1 WDR74 0.454 25416956 Q96DB2 Q6RFH5 HDAC11 WDR74 0.236 23752268 Q6RFH5 Q13769 WDR74 THOC5 0.236 26496610 Q6RFH5 P09450 WDR74 JUNB 0.236 26496610 Q99PL5 Q6RFH5 RRBP1 WDR74 0.236 26496610 Q6RFH5 P16234 WDR74 PDGFRA 0.236 26496610 Q6RFH5 Q16513 WDR74 PKN2 0.236 26496610 Q6RFH5 Q53F19 WDR74 C17ORF85 0.236 26496610 Q6RFH5 O00567 WDR74 NOP56 0.236 26496610 Q6RFH5 A2AHJ4 WDR74 BRWD3 0.236 26496610 Q6RFH5 O95989 WDR74 NUDT3 0.332 21900206 Q93009 Q6RFH5 USP7 WDR74 0.081 22939629 Q96PZ0 Q6RFH5 PUS7 WDR74 0.081 22939629 Q99536 Q6RFH5 VAT1 WDR74 0.081 22939629 Q6RFH5 Q13838 WDR74 DDX39B 0.081 22939629 Q6RFH5 Q14137 WDR74 BOP1 0.21 25825154 Q6RFH5 F8VQC1 WDR74 F8VQC1 0.126 26496610 Q6RFH5 Q15386 WDR74 UBE3C 0.081 22939629 Q6RFH5 Q16666 WDR74 IFI16 0.126 25693804 Q6RFH5 Q08J23 WDR74 NSUN2 0.081 22939629

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 NOP56 WDR74 MI:0045 experimental interaction detection MI:0461 interaction database XPO1 WDR74 MI:0045 experimental interaction detection MI:0461 interaction database UBD WDR74 MI:0045 experimental interaction detection MI:0461 interaction database SRP72 WDR74 MI:0362 inference MI:0461 interaction database NUDT3 WDR74 MI:0045 experimental interaction detection MI:0461 interaction database UBC WDR74 MI:0045 experimental interaction detection MI:0461 interaction database GSPT1 WDR74 MI:0362 inference MI:0461 interaction database PDGFRA WDR74 MI:0045 experimental interaction detection MI:0461 interaction database JUNB WDR74 MI:0362 inference MI:0461 interaction database CALR WDR74 MI:0362 inference MI:0461 interaction database RGS2 WDR74 MI:0045 experimental interaction detection MI:0461 interaction database RRP1 WDR74 MI:0362 inference MI:0461 interaction database EIF6 WDR74 MI:0362 inference MI:0461 interaction database THOC5 WDR74 MI:0045 experimental interaction detection MI:0461 interaction database BOP1 WDR74 MI:0045 experimental interaction detection MI:0461 interaction database RRP1B WDR74 MI:0362 inference MI:0461 interaction database PKN2 WDR74 MI:0045 experimental interaction detection MI:0461 interaction database IFI16 WDR74 MI:0045 experimental interaction detection MI:0461 interaction database NCBP3 WDR74 MI:0045 experimental interaction detection MI:0461 interaction database WDR74 BRWD3 MI:0362 inference MI:0461 interaction database WDR74 CCNJL MI:0045 experimental interaction detection MI:0461 interaction database WDR74 FTSJ3 MI:0362 inference MI:0461 interaction database WDR74 GSPT2 MI:0362 inference MI:0461 interaction database WDR74 HDAC11 MI:0045 experimental interaction detection MI:0461 interaction database WDR74 RCHY1 MI:0045 experimental interaction detection MI:0461 interaction database WDR74 MAK16 MI:0362 inference MI:0461 interaction database WDR74 NIFK MI:0362 inference MI:0461 interaction database WDR74 GTPBP4 MI:0362 inference MI:0461 interaction database WDR74 WDR12 MI:0362 inference MI:0461 interaction database WDR74 RPF1 MI:0362 inference MI:0461 interaction database WDR74 DDX18 MI:0362 inference MI:0461 interaction database WDR74 IBTK MI:0045 experimental interaction detection MI:0461 interaction database WDR74 RRBP1 MI:0362 inference MI:0461 interaction database WDR74 RSL24D1 MI:0362 inference MI:0461 interaction database WDR74 CARD8 MI:0045 experimental interaction detection MI:0461 interaction database