Mutation - TCGA Type Chromosome Start Position End Position Strand Variant Classification Variant Type Reference Allele Tumor_seq Allele 1 Tumor_seq Allele 2 Tumor Sample Barcode Matched Norm Sample Barcode Genome Change cDNA Change Codon Change Protein Change BLCA 8 33408568 33408568 + Silent SNP T T C TCGA-K4-A6MB-01A-11D-A31L-08 TCGA-K4-A6MB-10A-01D-A31J-08 g.chr8:33408568T>C c.264A>G c.(262-264)ttA>ttG p.L88L BRCA 8 33408602 33408602 + Splice_Site SNP A A C TCGA-A8-A0A6-01A-12W-A071-09 TCGA-A8-A0A6-10A-01W-A071-09 g.chr8:33408602A>C c.230T>G c.(229-231)gTg>gGg p.V77G COAD 8 33406291 33406291 + Missense_Mutation SNP G G T TCGA-AA-A00N-01A-02W-A00E-09 TCGA-AA-A00N-10A-01W-A00E-09 g.chr8:33406291G>T c.448C>A c.(448-450)Cta>Ata p.L150I COAD 8 33406360 33406360 + Missense_Mutation SNP G G A TCGA-AA-A00N-01A-02W-A00E-09 TCGA-AA-A00N-10A-01W-A00E-09 g.chr8:33406360G>A c.379C>T c.(379-381)Cgc>Tgc p.R127C COAD 8 33416167 33416167 + Missense_Mutation SNP T T C TCGA-F4-6856-01A-11D-1924-10 TCGA-F4-6856-10A-01D-1924-10 g.chr8:33416167T>C c.148A>G c.(148-150)Atg>Gtg p.M50V COADREAD 8 33406291 33406291 + Missense_Mutation SNP G G T TCGA-AA-A00N-01A-02W-A00E-09 TCGA-AA-A00N-10A-01W-A00E-09 g.chr8:33406291G>T c.448C>A c.(448-450)Cta>Ata p.L150I COADREAD 8 33406360 33406360 + Missense_Mutation SNP G G A TCGA-AA-A00N-01A-02W-A00E-09 TCGA-AA-A00N-10A-01W-A00E-09 g.chr8:33406360G>A c.379C>T c.(379-381)Cgc>Tgc p.R127C COADREAD 8 33406959 33406959 + Missense_Mutation SNP C C T TCGA-AG-A026-01A-32W-A096-10 TCGA-AG-A026-10A-01W-A096-10 g.chr8:33406959C>T c.322G>A c.(322-324)Gtg>Atg p.V108M COADREAD 8 33416167 33416167 + Missense_Mutation SNP T T C TCGA-F4-6856-01A-11D-1924-10 TCGA-F4-6856-10A-01D-1924-10 g.chr8:33416167T>C c.148A>G c.(148-150)Atg>Gtg p.M50V ESCA 8 33406936 33406936 + Frame_Shift_Del DEL A A - TCGA-L5-A8NG-01A-11D-A37C-09 TCGA-L5-A8NG-11A-11D-A37F-09 g.chr8:33406936delA c.345delT c.(343-345)tttfs p.F115fs ESCA 8 33406939 33406939 + Silent SNP G G A TCGA-XP-A8T6-01A-11D-A36J-09 TCGA-XP-A8T6-10A-01D-A36M-09 g.chr8:33406939G>A c.342C>T c.(340-342)gcC>gcT p.A114A GBMLGG 8 33406360 33406360 + Missense_Mutation SNP G G A TCGA-DU-6392-01A-11D-1705-08 TCGA-DU-6392-10A-01D-1705-08 g.chr8:33406360G>A c.379C>T c.(379-381)Cgc>Tgc p.R127C HNSC 8 33408567 33408568 + Frame_Shift_Ins INS - - T TCGA-CR-7395-01A-11D-2012-08 TCGA-CR-7395-10A-01D-2013-08 g.chr8:33408567_33408568insT c.264_265insA c.(262-267)ttatatfs p.Y89fs KICH 8 33408896 33408896 + Missense_Mutation SNP T T C TCGA-KM-8438-01A-11D-2310-10 TCGA-KM-8438-10A-01D-2311-10 g.chr8:33408896T>C c.194A>G c.(193-195)aAc>aGc p.N65S KIPAN 8 33408896 33408896 + Missense_Mutation SNP T T C TCGA-KM-8438-01A-11D-2310-10 TCGA-KM-8438-10A-01D-2311-10 g.chr8:33408896T>C c.194A>G c.(193-195)aAc>aGc p.N65S LGG 8 33406360 33406360 + Missense_Mutation SNP G G A TCGA-DU-6392-01A-11D-1705-08 TCGA-DU-6392-10A-01D-1705-08 g.chr8:33406360G>A c.379C>T c.(379-381)Cgc>Tgc p.R127C LUAD 8 33406305 33406305 + Missense_Mutation SNP T T C TCGA-44-A4SS-01A-11D-A24P-08 TCGA-44-A4SS-10A-01D-A24P-08 g.chr8:33406305T>C c.434A>G c.(433-435)cAg>cGg p.Q145R LUAD 8 33416262 33416262 + Missense_Mutation SNP C C A TCGA-75-6214-01A-41D-1945-08 TCGA-75-6214-10A-01D-1946-08 g.chr8:33416262C>A c.53G>T c.(52-54)aGc>aTc p.S18I LUAD 8 33416288 33416288 + Splice_Site SNP C C A TCGA-53-7624-01A-11D-2063-08 TCGA-53-7624-10A-01D-2063-08 g.chr8:33416288C>A c.27G>T c.(25-27)ggG>ggT p.G9G LUAD 8 33416289 33416289 + Splice_Site SNP C C A TCGA-55-7907-01A-11D-2167-08 TCGA-55-7907-10A-01D-2167-08 g.chr8:33416289C>A c.26G>T c.(25-27)gGg>gTg p.G9V OV 8 33408878 33408878 + Missense_Mutation SNP C C T TCGA-61-1906-01A-01W-0639-09 TCGA-61-1906-11A-01W-0640-09 g.chr8:33408878C>T c.212G>A c.(211-213)cGa>cAa p.R71Q PAAD 8 33406322 33406322 + Silent SNP A A G TCGA-IB-7651-01A-11D-2154-08 TCGA-IB-7651-10A-01D-2154-08 g.chr8:33406322A>G c.417T>C c.(415-417)agT>agC p.S139S READ 8 33406959 33406959 + Missense_Mutation SNP C C T TCGA-AG-A026-01A-32W-A096-10 TCGA-AG-A026-10A-01W-A096-10 g.chr8:33406959C>T c.322G>A c.(322-324)Gtg>Atg p.V108M SKCM 8 33406291 33406291 + Silent SNP G G A TCGA-DA-A1I0-06A-11D-A20D-08 TCGA-DA-A1I0-10B-01D-A20D-08 g.chr8:33406291G>A c.448C>T c.(448-450)Cta>Tta p.L150L SKCM 8 33406331 33406331 + Silent SNP G G A TCGA-D3-A3C8-06A-12D-A19A-08 TCGA-D3-A3C8-10A-01D-A19A-08 g.chr8:33406331G>A c.408C>T c.(406-408)ccC>ccT p.P136P SKCM 8 33406360 33406360 + Missense_Mutation SNP G G A TCGA-FS-A1ZK-06A-11D-A197-08 TCGA-FS-A1ZK-10A-01D-A199-08 g.chr8:33406360G>A c.379C>T c.(379-381)Cgc>Tgc p.R127C SKCM 8 33416159 33416159 + Silent SNP G G A TCGA-EE-A2MU-06A-21D-A196-08 TCGA-EE-A2MU-10A-01D-A198-08 g.chr8:33416159G>A c.156C>T c.(154-156)agC>agT p.S52S SKCM 8 33416195 33416195 + Silent SNP G G A TCGA-FW-A3R5-06A-11D-A23B-08 TCGA-FW-A3R5-10A-01D-A23B-08 g.chr8:33416195G>A c.120C>T c.(118-120)gtC>gtT p.V40V SKCM 8 33416214 33416214 + Missense_Mutation SNP G G A TCGA-EE-A2MR-06A-11D-A196-08 TCGA-EE-A2MR-10A-01D-A198-08 g.chr8:33416214G>A c.101C>T c.(100-102)cCg>cTg p.P34L

Mutation - ICGC Project Code Chromosome Chromosome Start Chromosome End Mutation Type Mutated from Allele Mutated to Allele Consequence Type AA Mutation CDS Mutation BRCA-EU 8 33401670 33401670 single base substitution C G downstream_gene_variant BRCA-EU 8 33401854 33401854 single base substitution A T downstream_gene_variant BRCA-EU 8 33403485 33403485 single base substitution G A downstream_gene_variant BRCA-EU 8 33407605 33407605 single base substitution C G intron_variant BRCA-EU 8 33408117 33408117 single base substitution C A intron_variant BRCA-EU 8 33411350 33411350 single base substitution C T intron_variant BRCA-EU 8 33412978 33412978 single base substitution C T intron_variant BRCA-EU 8 33413076 33413076 single base substitution C A intron_variant BRCA-EU 8 33416652 33416652 insertion of <=200bp - A intron_variant BRCA-EU 8 33416830 33416830 single base substitution T A intron_variant BRCA-EU 8 33417571 33417571 single base substitution G A intron_variant BRCA-EU 8 33419753 33419753 single base substitution A G intron_variant BRCA-EU 8 33421137 33421137 single base substitution G A intron_variant BRCA-EU 8 33421430 33421430 single base substitution C G intron_variant BRCA-EU 8 33423343 33423343 single base substitution G A intron_variant BRCA-EU 8 33423382 33423382 deletion of <=200bp T - intron_variant BRCA-EU 8 33423856 33423856 single base substitution G A intron_variant BRCA-EU 8 33424257 33424257 single base substitution T G 5_prime_UTR_variant BRCA-EU 8 33425106 33425106 single base substitution G A upstream_gene_variant BRCA-EU 8 33425219 33425219 single base substitution G A upstream_gene_variant BRCA-EU 8 33425982 33425982 single base substitution C G upstream_gene_variant BRCA-EU 8 33426080 33426080 deletion of <=200bp A - upstream_gene_variant BRCA-EU 8 33426111 33426111 single base substitution G A upstream_gene_variant BRCA-EU 8 33426671 33426671 single base substitution C G upstream_gene_variant BRCA-EU 8 33427937 33427937 single base substitution A G upstream_gene_variant BRCA-EU 8 33428286 33428286 single base substitution T G upstream_gene_variant BRCA-EU 8 33428708 33428708 single base substitution G T upstream_gene_variant BRCA-FR 8 33400683 33400683 single base substitution C A downstream_gene_variant BRCA-FR 8 33408117 33408117 single base substitution C A intron_variant BRCA-FR 8 33421430 33421430 single base substitution C G intron_variant BRCA-FR 8 33426671 33426671 single base substitution C G upstream_gene_variant BRCA-FR 8 33427937 33427937 single base substitution A G upstream_gene_variant BRCA-UK 8 33406398 33406398 single base substitution G A intron_variant BRCA-US 8 33408602 33408602 single base substitution A C missense_variant V77G 230T>G CLLE-ES 8 33422974 33422974 single base substitution G A intron_variant COAD-US 8 33416167 33416167 single base substitution T C missense_variant M50V 148A>G COCA-CN 8 33408595 33408595 single base substitution A C synonymous_variant L79L 237T>G COCA-CN 8 33408626 33408626 single base substitution A C intron_variant COCA-CN 8 33413413 33413413 single base substitution C T intron_variant COCA-CN 8 33417046 33417046 single base substitution A G intron_variant COCA-CN 8 33421857 33421857 single base substitution G A intron_variant COCA-CN 8 33423382 33423382 single base substitution T C intron_variant EOPC-DE 8 33403039 33403039 single base substitution C G downstream_gene_variant EOPC-DE 8 33427014 33427014 single base substitution T A upstream_gene_variant ESAD-UK 8 33401080 33401080 single base substitution G A downstream_gene_variant ESAD-UK 8 33401227 33401227 single base substitution C T downstream_gene_variant ESAD-UK 8 33401635 33401635 single base substitution G A downstream_gene_variant ESAD-UK 8 33401729 33401729 single base substitution G A downstream_gene_variant ESAD-UK 8 33403139 33403139 single base substitution G A downstream_gene_variant ESAD-UK 8 33406307 33406307 single base substitution C T synonymous_variant T144T 432G>A ESAD-UK 8 33408779 33408779 single base substitution G A intron_variant ESAD-UK 8 33411169 33411169 single base substitution G T intron_variant ESAD-UK 8 33411754 33411754 single base substitution G C intron_variant ESAD-UK 8 33413928 33413928 single base substitution G A intron_variant ESAD-UK 8 33418404 33418404 single base substitution G A intron_variant ESAD-UK 8 33420155 33420155 single base substitution G A intron_variant ESAD-UK 8 33421810 33421810 single base substitution A T intron_variant ESAD-UK 8 33423207 33423207 single base substitution G C intron_variant ESAD-UK 8 33423228 33423228 single base substitution G A intron_variant ESAD-UK 8 33423965 33423965 single base substitution C T intron_variant ESAD-UK 8 33425381 33425381 single base substitution G C upstream_gene_variant ESAD-UK 8 33425859 33425859 single base substitution A G upstream_gene_variant ESAD-UK 8 33425987 33425987 single base substitution C A upstream_gene_variant ESAD-UK 8 33427958 33427958 single base substitution G A upstream_gene_variant ESAD-UK 8 33428477 33428477 single base substitution C T upstream_gene_variant ESAD-UK 8 33429022 33429022 single base substitution C A upstream_gene_variant ESAD-UK 8 33429536 33429536 single base substitution C T upstream_gene_variant LICA-FR 8 33416202 33416202 single base substitution T C missense_variant Y38C 113A>G LICA-FR 8 33422900 33422900 insertion of <=200bp - T intron_variant LIHC-US 8 33416214 33416214 single base substitution G T missense_variant P34Q 101C>A LINC-JP 8 33410254 33410254 single base substitution G A intron_variant LINC-JP 8 33415175 33415175 single base substitution T A intron_variant LINC-JP 8 33415317 33415317 single base substitution T G intron_variant LIRI-JP 8 33400916 33400916 single base substitution A G downstream_gene_variant LIRI-JP 8 33401552 33401552 single base substitution T C downstream_gene_variant LIRI-JP 8 33407019 33407019 single base substitution A C intron_variant LIRI-JP 8 33408639 33408639 single base substitution A G intron_variant LIRI-JP 8 33414337 33414337 single base substitution T C intron_variant LIRI-JP 8 33416875 33416876 deletion of <=200bp GA - intron_variant LIRI-JP 8 33418693 33418693 single base substitution C T intron_variant LIRI-JP 8 33419636 33419636 single base substitution A G intron_variant LIRI-JP 8 33423555 33423555 single base substitution G C intron_variant LIRI-JP 8 33427473 33427473 single base substitution C T upstream_gene_variant LIRI-JP 8 33428367 33428367 single base substitution A G upstream_gene_variant LIRI-JP 8 33429299 33429299 single base substitution T C upstream_gene_variant LUSC-KR 8 33403487 33403487 single base substitution G A downstream_gene_variant LUSC-KR 8 33406996 33406996 single base substitution G T synonymous_variant V95V 285C>A LUSC-KR 8 33409874 33409874 single base substitution G T intron_variant LUSC-KR 8 33410693 33410693 single base substitution G A intron_variant LUSC-KR 8 33412216 33412216 single base substitution A C intron_variant LUSC-KR 8 33421674 33421674 single base substitution C T intron_variant LUSC-KR 8 33426026 33426026 single base substitution T A upstream_gene_variant LUSC-KR 8 33428202 33428202 single base substitution C A upstream_gene_variant LUSC-KR 8 33429211 33429211 single base substitution C A upstream_gene_variant MALY-DE 8 33411174 33411174 single base substitution C G intron_variant MALY-DE 8 33411599 33411599 single base substitution C T intron_variant MALY-DE 8 33417446 33417446 single base substitution G A intron_variant MALY-DE 8 33422906 33422906 single base substitution T C intron_variant MALY-DE 8 33429402 33429402 single base substitution T G upstream_gene_variant MELA-AU 8 33400411 33400411 single base substitution G A downstream_gene_variant MELA-AU 8 33400689 33400689 single base substitution G A downstream_gene_variant MELA-AU 8 33400748 33400748 single base substitution C T downstream_gene_variant MELA-AU 8 33400906 33400906 single base substitution C T downstream_gene_variant MELA-AU 8 33401937 33401937 single base substitution C T downstream_gene_variant MELA-AU 8 33402444 33402444 single base substitution G A downstream_gene_variant MELA-AU 8 33404943 33404943 single base substitution G A downstream_gene_variant MELA-AU 8 33404975 33404975 single base substitution A T downstream_gene_variant MELA-AU 8 33405010 33405010 single base substitution G A downstream_gene_variant MELA-AU 8 33405350 33405350 single base substitution G A 3_prime_UTR_variant MELA-AU 8 33405663 33405663 single base substitution G A 3_prime_UTR_variant MELA-AU 8 33405804 33405804 single base substitution C T 3_prime_UTR_variant MELA-AU 8 33405845 33405845 single base substitution G A 3_prime_UTR_variant MELA-AU 8 33405857 33405857 single base substitution G A 3_prime_UTR_variant MELA-AU 8 33406067 33406067 single base substitution G A 3_prime_UTR_variant MELA-AU 8 33406646 33406646 single base substitution G A intron_variant MELA-AU 8 33407109 33407109 single base substitution C T intron_variant MELA-AU 8 33408606 33408606 single base substitution G A splice_region_variant MELA-AU 8 33408681 33408681 single base substitution G A intron_variant MELA-AU 8 33408935 33408935 single base substitution A T intron_variant MELA-AU 8 33409006 33409006 single base substitution G A intron_variant MELA-AU 8 33409509 33409509 single base substitution G A intron_variant MELA-AU 8 33409588 33409588 single base substitution G A intron_variant MELA-AU 8 33409688 33409688 single base substitution G A intron_variant MELA-AU 8 33409832 33409832 single base substitution G A intron_variant MELA-AU 8 33409885 33409885 single base substitution C A intron_variant MELA-AU 8 33410565 33410565 single base substitution G A intron_variant MELA-AU 8 33411694 33411694 single base substitution G A intron_variant MELA-AU 8 33412186 33412186 single base substitution G A intron_variant MELA-AU 8 33412381 33412381 single base substitution G A intron_variant MELA-AU 8 33413156 33413156 single base substitution G A intron_variant MELA-AU 8 33413187 33413187 single base substitution G A intron_variant MELA-AU 8 33414407 33414407 single base substitution G A intron_variant MELA-AU 8 33415237 33415237 single base substitution G T intron_variant MELA-AU 8 33415325 33415325 insertion of <=200bp - TTTTGGT intron_variant MELA-AU 8 33415813 33415813 single base substitution C A intron_variant MELA-AU 8 33416105 33416105 single base substitution C T intron_variant MELA-AU 8 33416893 33416893 single base substitution G A intron_variant MELA-AU 8 33417748 33417748 single base substitution C T intron_variant MELA-AU 8 33418283 33418283 single base substitution C T intron_variant MELA-AU 8 33418510 33418510 single base substitution G A intron_variant MELA-AU 8 33418692 33418692 single base substitution G A intron_variant MELA-AU 8 33419027 33419027 single base substitution C T intron_variant MELA-AU 8 33419308 33419308 single base substitution G T intron_variant MELA-AU 8 33420187 33420187 single base substitution A G intron_variant MELA-AU 8 33420939 33420939 single base substitution G A intron_variant MELA-AU 8 33421275 33421275 single base substitution G A intron_variant MELA-AU 8 33421326 33421326 single base substitution G A intron_variant MELA-AU 8 33421678 33421678 single base substitution G A intron_variant MELA-AU 8 33422012 33422012 single base substitution G A intron_variant MELA-AU 8 33422026 33422026 single base substitution G A intron_variant MELA-AU 8 33422687 33422687 single base substitution G A intron_variant MELA-AU 8 33422788 33422788 single base substitution G A intron_variant MELA-AU 8 33422958 33422958 single base substitution C T intron_variant MELA-AU 8 33424574 33424574 single base substitution G A 5_prime_UTR_variant MELA-AU 8 33424695 33424695 single base substitution G A upstream_gene_variant MELA-AU 8 33424696 33424696 single base substitution G A upstream_gene_variant MELA-AU 8 33424749 33424749 single base substitution C T upstream_gene_variant MELA-AU 8 33425644 33425644 single base substitution G C upstream_gene_variant MELA-AU 8 33426454 33426454 single base substitution T C upstream_gene_variant MELA-AU 8 33427045 33427045 single base substitution G A upstream_gene_variant MELA-AU 8 33427461 33427461 single base substitution G A upstream_gene_variant MELA-AU 8 33427815 33427815 single base substitution G A upstream_gene_variant MELA-AU 8 33427961 33427961 single base substitution A T upstream_gene_variant MELA-AU 8 33427977 33427977 deletion of <=200bp T - upstream_gene_variant MELA-AU 8 33428094 33428094 single base substitution G A upstream_gene_variant MELA-AU 8 33428278 33428278 single base substitution G A upstream_gene_variant MELA-AU 8 33428524 33428524 single base substitution G A upstream_gene_variant MELA-AU 8 33428616 33428616 single base substitution C T upstream_gene_variant ORCA-IN 8 33404021 33404021 single base substitution G A downstream_gene_variant ORCA-IN 8 33409933 33409933 single base substitution G C intron_variant ORCA-IN 8 33428800 33428800 single base substitution G A upstream_gene_variant OV-AU 8 33400538 33400538 single base substitution T C downstream_gene_variant OV-AU 8 33400587 33400587 single base substitution G A downstream_gene_variant OV-AU 8 33407784 33407784 single base substitution C A intron_variant OV-AU 8 33412369 33412369 single base substitution C T intron_variant OV-AU 8 33412430 33412430 single base substitution G C intron_variant OV-AU 8 33414052 33414052 single base substitution C G intron_variant OV-AU 8 33414390 33414390 single base substitution G C intron_variant OV-AU 8 33423894 33423894 single base substitution G A intron_variant OV-AU 8 33426468 33426468 single base substitution T A upstream_gene_variant PACA-AU 8 33403639 33403639 single base substitution A G downstream_gene_variant PACA-AU 8 33409710 33409710 single base substitution T G intron_variant PACA-AU 8 33411388 33411388 single base substitution C G intron_variant PACA-AU 8 33421831 33421831 single base substitution C T intron_variant PACA-AU 8 33423894 33423894 single base substitution G T intron_variant PACA-CA 8 33401194 33401194 single base substitution G A downstream_gene_variant PACA-CA 8 33401342 33401342 single base substitution A T downstream_gene_variant PACA-CA 8 33402524 33402524 single base substitution G A downstream_gene_variant PACA-CA 8 33402532 33402532 insertion of <=200bp - C downstream_gene_variant PACA-CA 8 33404847 33404847 single base substitution A C downstream_gene_variant PACA-CA 8 33406170 33406170 single base substitution G A 3_prime_UTR_variant PACA-CA 8 33407307 33407307 single base substitution C T intron_variant PACA-CA 8 33409583 33409583 single base substitution T G intron_variant PACA-CA 8 33411181 33411181 single base substitution C A intron_variant PACA-CA 8 33415441 33415441 single base substitution A T intron_variant PACA-CA 8 33416010 33416010 single base substitution A T intron_variant PACA-CA 8 33418625 33418625 deletion of <=200bp T - intron_variant PACA-CA 8 33420231 33420231 single base substitution C T intron_variant PACA-CA 8 33423349 33423349 single base substitution C G intron_variant PACA-CA 8 33423881 33423881 single base substitution C A intron_variant PACA-CA 8 33423929 33423929 single base substitution G C intron_variant PACA-CA 8 33424540 33424540 single base substitution C A 5_prime_UTR_variant PACA-CA 8 33426170 33426170 single base substitution G A upstream_gene_variant PACA-CA 8 33428532 33428532 single base substitution G A upstream_gene_variant PAEN-AU 8 33410103 33410103 single base substitution G A intron_variant PAEN-AU 8 33412712 33412712 single base substitution G T intron_variant PBCA-DE 8 33401844 33401844 single base substitution T C downstream_gene_variant PBCA-DE 8 33419970 33419970 single base substitution G T intron_variant PBCA-DE 8 33426922 33426922 single base substitution G T upstream_gene_variant PRAD-CA 8 33416573 33416573 single base substitution G T intron_variant PRAD-UK 8 33412265 33412265 single base substitution C T intron_variant PRAD-UK 8 33414147 33414147 single base substitution C T intron_variant PRAD-UK 8 33429270 33429270 single base substitution G C upstream_gene_variant RECA-EU 8 33406570 33406570 single base substitution C A intron_variant RECA-EU 8 33422813 33422813 single base substitution T C intron_variant RECA-EU 8 33424534 33424534 single base substitution G C 5_prime_UTR_variant SKCA-BR 8 33402084 33402084 single base substitution C T downstream_gene_variant SKCA-BR 8 33402443 33402443 single base substitution G A downstream_gene_variant SKCA-BR 8 33404019 33404019 single base substitution T A downstream_gene_variant SKCA-BR 8 33404256 33404256 single base substitution G A downstream_gene_variant SKCA-BR 8 33405045 33405045 single base substitution G A downstream_gene_variant SKCA-BR 8 33407121 33407121 single base substitution C T intron_variant SKCA-BR 8 33407400 33407400 single base substitution C T intron_variant SKCA-BR 8 33409746 33409746 single base substitution T C intron_variant SKCA-BR 8 33411333 33411333 single base substitution G A intron_variant SKCA-BR 8 33415797 33415797 single base substitution T A intron_variant SKCA-BR 8 33415894 33415894 single base substitution G A intron_variant SKCA-BR 8 33416168 33416168 single base substitution G A synonymous_variant F49F 147C>T SKCA-BR 8 33416303 33416303 insertion of <=200bp - GA intron_variant SKCA-BR 8 33419068 33419068 single base substitution T A intron_variant SKCA-BR 8 33422899 33422899 insertion of <=200bp - AT intron_variant SKCA-BR 8 33423919 33423919 single base substitution A G intron_variant SKCM-US 8 33406291 33406291 single base substitution G A synonymous_variant L150L 448C>T SKCM-US 8 33406331 33406331 single base substitution G A synonymous_variant P136P 408C>T SKCM-US 8 33406360 33406360 single base substitution G A missense_variant R127C 379C>T SKCM-US 8 33416159 33416159 single base substitution G A synonymous_variant S52S 156C>T SKCM-US 8 33416214 33416214 single base substitution G A missense_variant P34L 101C>T STAD-US 8 33408905 33408905 single base substitution T G missense_variant K62T 185A>C STAD-US 8 33416169 33416182 deletion of <=200bp AAGACAAAGATGCC - frameshift_variant GIFVF45 STAD-US 8 33416224 33416224 single base substitution G A stop_gained Q31* 91C>T STAD-US 8 33416236 33416236 single base substitution G A missense_variant P27S 79C>T STAD-US 8 33416240 33416240 single base substitution C T missense_variant M25I 75G>A THCA-SA 8 33405694 33405694 single base substitution C G 3_prime_UTR_variant THCA-SA 8 33408901 33408901 single base substitution C G synonymous_variant L63L 189G>C UCEC-US 8 33406944 33406944 single base substitution G A missense_variant H113Y 337C>T UCEC-US 8 33407002 33407002 single base substitution G A synonymous_variant C93C 279C>T UCEC-US 8 33416277 33416277 single base substitution C T missense_variant G13D 38G>A UCEC-US 8 33424237 33424237 single base substitution T C missense_variant H2R 5A>G

Mutation - COSMIC Sample Name Mutation ID Mutation CDS Mutation AA Mutation Description Mutation Genome Position Mutation Strand TCGA-DA-A1I0-06 COSM3925219 c.448C>T p.L150L Substitution - coding silent 8:33548773-33548773 - 1604875 COSM141228 c.261A>T p.Q87H Substitution - Missense 8:33551053-33551053 - SNUH_G10_S1 COSM3982528 c.93G>A p.Q31Q Substitution - coding silent 8:33558704-33558704 - TCGA-D3-A3C8-06 COSM3648578 c.408C>T p.P136P Substitution - coding silent 8:33548813-33548813 - TCGA-BR-8690-01 COSM3899787 c.91C>T p.Q31* Substitution - Nonsense 8:33558706-33558706 - CHC703T COSM4957385 c.113A>G p.Y38C Substitution - Missense 8:33558684-33558684 - TCGA-D1-A17U-01 COSM1099350 c.337C>T p.H113Y Substitution - Missense 8:33549426-33549426 - 2_PRE-TREATMENT COSM1722621 c.97C>T p.L33F Substitution - Missense 8:33558700-33558700 - TCGA-EI-6884-01 COSM5079654 c.25+7C>T p.? Unknown 8:33566692-33566692 - TCGA-HU-8602-01 COSM3899788 c.79C>T p.P27S Substitution - Missense 8:33558718-33558718 - TCGA-AP-A051-01 COSM1099351 c.279C>T p.C93C Substitution - coding silent 8:33549484-33549484 - TCGA-EE-A2MR-06 COSM3648580 c.101C>T p.P34L Substitution - Missense 8:33558696-33558696 - TCGA-EE-A2MU-06 COSM3648579 c.156C>T p.S52S Substitution - coding silent 8:33558641-33558641 - TCGA-AF-6136-01 COSM5065923 c.182+5G>A p.? Unknown 8:33558610-33558610 - 2_RESISTANT COSM1722621 c.97C>T p.L33F Substitution - Missense 8:33558700-33558700 - TCGA-61-1906-01 COSM1331010 c.212G>A p.R71Q Substitution - Missense 8:33551360-33551360 - TCGA-WS-AB45-01 COSM5191817 c.329C>T p.P110L Substitution - Missense 8:33549434-33549434 - J36_T COSM3951611 c.285C>A p.V95V Substitution - coding silent 8:33549478-33549478 - TCGA-G3-A25U-01 COSM4911171 c.101C>A p.P34Q Substitution - Missense 8:33558696-33558696 - CHC703T COSM4957385 c.113A>G p.Y38C Substitution - Missense 8:33558684-33558684 - TCGA-AG-A026-01 COSM290528 c.322G>A p.V108M Substitution - Missense 8:33549441-33549441 - OV207 COSM252782 c.211C>T p.R71* Substitution - Nonsense 8:33551361-33551361 - PTC-28C COSM3982527 c.126C>T p.F42F Substitution - coding silent 8:33558671-33558671 - TCGA-BR-8589-01 COSM3899786 c.185A>C p.K62T Substitution - Missense 8:33551387-33551387 - TCGA-AA-A00N-01 COSM277080 c.379C>T p.R127C Substitution - Missense 8:33548842-33548842 - TCGA-FS-A1ZK-06 COSM277080 c.379C>T p.R127C Substitution - Missense 8:33548842-33548842 - CSCC-17-T COSM4536151 c.226G>T p.E76* Substitution - Nonsense 8:33551346-33551346 - RK209_C01 COSM1635767 c.271-9T>G p.? Unknown 8:33549501-33549501 - SNUH_G10_S1 COSM3982527 c.126C>T p.F42F Substitution - coding silent 8:33558671-33558671 - TCGA-D1-A103-01 COSM1099352 c.38G>A p.G13D Substitution - Missense 8:33558759-33558759 - TCGA-F4-6856-01 COSM1456756 c.148A>G p.M50V Substitution - Missense 8:33558649-33558649 - TCGA-BR-6802-01 COSM3899789 c.75G>A p.M25I Substitution - Missense 8:33558722-33558722 - sysucc-1150T COSM5452632 c.237T>G p.L79L Substitution - coding silent 8:33551077-33551077 - TCGA-AA-A00N-01 COSM277079 c.448C>A p.L150I Substitution - Missense 8:33548773-33548773 - TCGA-D1-A176-01 COSM1099353 c.5A>G p.H2R Substitution - Missense 8:33566719-33566719 - TCGA-A8-A0A6-01 COSM3834611 c.230T>G p.V77G Substitution - Missense 8:33551084-33551084 - LP6005500-DNA_F02 COSM2959219 c.432G>A p.T144T Substitution - coding silent 8:33548789-33548789 -

Mutation - CGAP UNIGENE CYTOBAND OMIM SNP Hs.151227;Hs.151229;Hs.151237 8p12

Mutation - IntOGen Mutated from(ref) Mutated to(alt) Consequence Type AA Mutation CDS Mutation Chr Pos Cancer C T Missense p.V108M c.322G>A 8 33406959 COREAD G A Missense p.H113Y c.337C>T 8 33406944 UCEC G A Missense p.R127C c.379C>T 8 33406360 CM G A Synonymous p.L150L c.448C>T 8 33406291 CM G A Synonymous p.P136P c.408C>T 8 33406331 CM G A Synonymous p.S52S c.156C>T 8 33416159 CM T C Missense p.H2R c.5A>G 8 33424237 UCEC - T Frameshift p.Y89Ifs*17 c.264dupA 8 33408568 HNSC